Matthias Hebrok, PhD

Title(s)Professor, Diabetes Center
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-514-0820
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    Other Positions
    Title(s)Director, Diabetes Center


    Collapse Overview 
    Collapse Overview
    The main focus of my lab is to understand how islets of Langerhans, the endocrine component of the pancreas, are formed during organogenesis, how their function is regulated in the mature organism, and how changes in gene expression might allow islet regeneration. Islet cells, including glucagon-producing a- and insulin-producing ß-cells, regulate blood glucose homeostasis. The importance of the latter is highlighted by the fact that loss of ß-cells leads to type I diabetes mellitus. Conventional treatment of diabetic patients is based on insulin injections. Unfortunately, episodes of hypo- and hyperglycemia occur frequently and result in severe secondary complications, including coronary and microvascular diseases. Recent reports have shown that islet transplantation successfully restores glucose tolerance. However islets are in short supply, a dilemma that severely restricts the feasibility of large-scale therapy through islet transplantation. An alternative approach is the regeneration of ß- or islet cells from committed precursor cells and the majority of the projects in my lab are designed to unravel the program that directs an ordinary cell in the gut to become a ß-cell. Understanding of these processes will be crucial for future cell replacement strategies.

    Analysis of known signaling pathways: We employ knockout and transgenic mice lines to study the effect of known signaling pathways involved in cell proliferation, differentiation and migration on islet progenitor cells. In particular, we are interested in understanding how components of the Hedgehog and Wnt pathways influence pancreas development and endocrine cell differentiation. While previous studies have suggested an inhibitory role for members of the Hedgehog family, our recent results indicate that some Hedgehog signaling is required for pancreas formation. Currently, we are using a combination of knockout and transgenic approaches to determine if manipulations of the Hedgehog and Wnt pathways stimulate ß-cell development and function.

    Identification of novel pancreas/islet genes: In another set of experiments we have identified novel pancreatic genes via 'gene-trapping'. This technique allows to randomly trap and mark genes by inserting a target construct containing the bacterial LacZ gene into the DNA of embryonic stem (ES) cells. Trapped genes are identified by sequencing of amplified cDNA fragments (5' RACE) and mouse lines are established by blastocyst injection. The insertion of the gene-trap vector places the bacterial ß-galactosidase gene under control of the promoter of the trapped gene. Thus, the normal expression pattern of this gene can rapidly be visualized by staining for ß-galactosidase activity within any given tissue, including the pancreas. More importantly, vector insertion causes either null or severe hypomorphic mutations that reveal if the trapped gene is essential for pancreas and ß-cell differentiation. These studies are done in collaboration with Marc Tessier-Lavigne, Stanford University, who is interested in brain development and is generously providing mice for our analysis.

    Generation of ß-cells from adult progenitor cells: Recent studies have shown that adult organ stem cells have the ability to develop into a number of different tissues. We are taking advantage of our understanding of pancreas development and have started to investigate if adult progenitor cells have the potential to develop into insulin-producing ß-cells. Bone marrow derived stem cells are co-cultured with embryonic pancreas buds that develop into endocrine islets and thus provide the necessary signals for ß-cell differentiation. Initially, we focus on murine adult stem cells, but will include human cells as soon as the 'proof of principle' experiments have shown that murine cells can adopt pancreatic fates.

    Model systems for pancreatic cancer: Overt hedgehog signaling has been implicated in cancer formation in various tissues; however it has not been linked to the formation of pancreatic adenocarcinomas, an aggressive form of cancer that is virtually incurable. We have started collaboration with Martin McMahon's laboratory at the UCSF Cancer Center to show that deregulated Hedgehog signaling promotes proliferation of pancreatic cancer cell lines and if inhibition of Hedgehog signaling blocks cell proliferation. Currently, we are manipulating the Hedgehog pathway in pancreatic tissue of transgenic animals to address the tumorigenic activity of this pathway in vivo.

    Collapse Research 
    Collapse Research Activities and Funding
    Real-time intracellular monitoring of microRNAs in human stem cell-derived insulin producing organoids
    NIH R43DK130034Sep 6, 2021 - Aug 31, 2022
    Role: Co-Principal Investigator
    Modulating intrinsic beta cell stress to block diabetes pathogenesis
    NIH R01DK129935Aug 15, 2021 - Jun 30, 2025
    Role: Principal Investigator
    Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systems
    NIH U01DK123559Sep 20, 2019 - May 31, 2023
    Role: Co-Principal Investigator
    Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes Mellitus
    NIH UH3DK120004Sep 20, 2018 - Jul 31, 2023
    Role: Co-Principal Investigator
    Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes Mellitus
    NIH UG3DK120004Sep 20, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH U01DK107383Jul 1, 2016 - Dec 31, 2020
    Role: Co-Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH/NIDDK R01DK107383Jul 1, 2016 - Jun 30, 2020
    Role: Co-Principal Investigator
    Mechanisms of beta cell maturation
    NIH R01DK108666Sep 30, 2015 - Jul 31, 2019
    Role: Principal Investigator
    Regulation of beta cell identity and dedifferentiation
    NIH R01DK105831May 1, 2015 - Jul 31, 2023
    Role: Principal Investigator
    Epigenetic regulation of pancreatic cancer
    NIH R01CA172045Apr 3, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Defining the role of MafA in islet beta cells
    NIH R01DK090570Jul 29, 2011 - May 31, 2026
    Role: Co-Principal Investigator
    Expanding beta-cell mass
    NIH U01DK089541Sep 15, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Embryonic signaling pathways in pancreatic cancer
    NIH R01CA112537Sep 1, 2004 - Nov 30, 2015
    Role: Principal Investigator
    Diabetes Research Center
    NIH P30DK063720Sep 1, 2002 - Mar 31, 2021
    Role: Co-Investigator
    Effects of Hedgehog Signaling on Pancreas Organogenesis
    NIH R01DK060533Dec 1, 2001 - Feb 28, 2014
    Role: Principal Investigator
    Molecular Control of Pancreatic Islet Development
    NIH U19DK061245Sep 30, 2001 - Jul 31, 2006
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses. JCI Insight. 2022 May 23; 7(10). Emfinger CH, de Klerk E, Schueler KL, Rabaglia ME, Stapleton DS, Simonett SP, Mitok KA, Wang Z, Liu X, Paulo JA, Yu Q, Cardone RL, Foster HR, Lewandowski SL, Perales JC, Kendziorski CM, Gygi SP, Kibbey RG, Keller MP, Hebrok M, Merrins MJ, Attie AD. PMID: 35603790.
      View in: PubMed   Mentions:
    2. Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus. Hum Gene Ther. 2022 May 10. Chai S, Kim Y, Galivo F, Dorrell C, Wakefield L, Posey J, Ackermann AM, Kaestner KH, Hebrok M, Grompe M. PMID: 35297680.
      View in: PubMed   Mentions:
    3. Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells. Stem Cell Reports. 2022 Apr 12; 17(4):979-992. Parent AV, Ashe S, Nair GG, Li ML, Chavez J, Liu JS, Zhong Y, Streeter PR, Hebrok M. PMID: 35245441; PMCID: PMC9023773.
      View in: PubMed   Mentions:
    4. Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation. Commun Biol. 2021 11 17; 4(1):1298. Heller S, Li Z, Lin Q, Geusz R, Breunig M, Hohwieler M, Zhang X, Nair GG, Seufferlein T, Hebrok M, Sander M, Julier C, Kleger A, Costa IG. PMID: 34789845; PMCID: PMC8599846.
      View in: PubMed   Mentions:
    5. Mutations and variants of ONECUT1 in diabetes. Nat Med. 2021 11; 27(11):1928-1940. Philippi A, Heller S, Costa IG, Senée V, Breunig M, Li Z, Kwon G, Russell R, Illing A, Lin Q, Hohwieler M, Degavre A, Zalloua P, Liebau S, Schuster M, Krumm J, Zhang X, Geusz R, Benthuysen JR, Wang A, Chiou J, Gaulton K, Neubauer H, Simon E, Klein T, Wagner M, Nair G, Besse C, Dandine-Roulland C, Olaso R, Deleuze JF, Kuster B, Hebrok M, Seufferlein T, Sander M, Boehm BO, Oswald F, Nicolino M, Julier C, Kleger A. PMID: 34663987.
      View in: PubMed   Mentions:    Fields:    
    6. Pancreatic β-Cell Development and Regeneration. Cold Spring Harb Perspect Biol. 2021 Sep 27. Kerper N, Ashe S, Hebrok M. PMID: 34580120.
      View in: PubMed   Mentions:    Fields:    
    7. Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection. Cell Rep. 2021 08 17; 36(7):109538. Parent AV, Faleo G, Chavez J, Saxton M, Berrios DI, Kerper NR, Tang Q, Hebrok M. PMID: 34407395.
      View in: PubMed   Mentions:    Fields:    
    8. Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications. J Biomed Mater Res A. 2021 12; 109(12):2438-2448. Shaheen R, Gurlin RE, Gologorsky R, Blaha C, Munnangi P, Santandreu A, Torres A, Carnese P, Nair GG, Szot G, Fissell WH, Hebrok M, Roy S. PMID: 34196100.
      View in: PubMed   Mentions:    Fields:    
    9. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. Elife. 2021 05 19; 10. Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, Hebrok M. PMID: 34009124; PMCID: PMC8184217.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Stem Cell-Based Clinical Trials for Diabetes Mellitus. Front Endocrinol (Lausanne). 2021; 12:631463. de Klerk E, Hebrok M. PMID: 33716982; PMCID: PMC7953062.
      View in: PubMed   Mentions: 2  
    11. Non-xenogeneic expansion and definitive endoderm differentiation of human pluripotent stem cells in an automated bioreactor. Biotechnol Bioeng. 2021 02; 118(2):979-991. Jacobson EF, Chen Z, Stoukides DM, Nair GG, Hebrok M, Tzanakakis ES. PMID: 33205831.
      View in: PubMed   Mentions:    Fields:    
    12. Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy. Nat Rev Endocrinol. 2020 09; 16(9):506-518. Nair GG, Tzanakakis ES, Hebrok M. PMID: 32587391.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    13. Loss of the transcription factor MAFB limits β-cell derivation from human PSCs. Nat Commun. 2020 06 02; 11(1):2742. Russell R, Carnese PP, Hennings TG, Walker EM, Russ HA, Liu JS, Giacometti S, Stein R, Hebrok M. PMID: 32488111; PMCID: PMC7265500.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. LIN28B Impairs the Transition of hESC-Derived β Cells from the Juvenile to Adult State. Stem Cell Reports. 2020 01 14; 14(1):9-20. Zhou X, Nair GG, Russ HA, Belair CD, Li ML, Shveygert M, Hebrok M, Blelloch R. PMID: 31883920; PMCID: PMC6962644.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health. Diabetes. 2020 03; 69(3):342-354. Tong X, Dai C, Walker JT, Nair GG, Kennedy A, Carr RM, Hebrok M, Powers AC, Stein R. PMID: 31836690; PMCID: PMC7034188.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    16. Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors. JCI Insight. 2019 11 14; 4(22). Pekrun K, De Alencastro G, Luo QJ, Liu J, Kim Y, Nygaard S, Galivo F, Zhang F, Song R, Tiffany MR, Xu J, Hebrok M, Grompe M, Kay MA. PMID: 31723052; PMCID: PMC6948855.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    17. Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids. Adv Biosyst. 2019 Sep; 3(9). Chendke GS, Faleo G, Juang C, Parent AV, Bernards DA, Hebrok M, Tang Q, Desai TA. PMID: 31633004; PMCID: PMC6800235.
      View in: PubMed   Mentions: 1  
    18. mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes. J Clin Invest. 2019 07 02; 129(10):4124-4137. Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A. PMID: 31265435; PMCID: PMC6763225.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    19. The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function. Diabetes. 2019 09; 68(9):1806-1818. Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, Wright CVE, Stein R. PMID: 31201281; PMCID: PMC6702633.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    20. Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells. Nat Cell Biol. 2019 06; 21(6):792. Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M. PMID: 30914825.
      View in: PubMed   Mentions:    Fields:    
    21. Pancreatic pericytes originate from the embryonic pancreatic mesenchyme. Dev Biol. 2019 05 01; 449(1):14-20. Harari N, Sakhneny L, Khalifa-Malka L, Busch A, Hertel KJ, Hebrok M, Landsman L. PMID: 30771302.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. Rapid generation of functional mature pancreatic islet-beta cells from human pluripotent stem cells. Protocol Exchange. 2019 Feb 4. Nair NG, Nair NG, Russ RH, Hebrok HM. .
      View in: Publisher Site   Mentions:
    23. Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells. Nat Cell Biol. 2019 02; 21(2):263-274. Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M. PMID: 30710150; PMCID: PMC6746427.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    24. The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis. J Clin Invest. 2018 08 01; 128(8):3475-3489. Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H. PMID: 30010625; PMCID: PMC6063489.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    25. Co-Transplant of Parathyroid Gland and Stem Cell-Derived Insulin-Producing Cells Enhances Graft Survival through Release of Pro-Angiogenic and Pro-Survival Factors. Transplantation Journal. 2018 Jul 1; 102(&NA;):s350. Faleo FG, Ward WC, Parent PA, Nair NG, Chang CW, Stock SP, Hebrok HM, Tang TQ. .
      View in: Publisher Site   Mentions:
    26. Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell. 2018 Jun 01; 22(6):810-823. Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M. PMID: 29859172; PMCID: PMC6007036.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    27. Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev Cell. 2018 05 07; 45(3):347-361.e5. Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G. PMID: 29656931; PMCID: PMC5962294.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    28. Replication confers β cell immaturity. Nat Commun. 2018 02 02; 9(1):485. Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M. PMID: 29396395; PMCID: PMC5797102.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    29. Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. Stem Cell Reports. 2017 09 12; 9(3):807-819. Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q. PMID: 28803916; PMCID: PMC5599226.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    30. Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy. ACS Nano. 2017 08 22; 11(8):7747-7757. Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA. PMID: 28763191; PMCID: PMC5667644.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    31. Corticotropin-releasing hormone type 2 receptor deficiency impairs pancreatic function in a sex-specific manner. Pancreatology. 2017 Jul 1; 17(3):s8. Bhargava BA, Hagiwara HS, Puri PS, Hebrok HM, Szot SG, Hasdemir HB, Paruthiyil PS. .
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    32. Atypical flat lesions derive from pancreatic acinar cells. Pancreatology. 2017 May - Jun; 17(3):350-353. von Figura G, Fahrenkrog-Petersen L, Hidalgo-Sastre A, Hartmann D, Hüser N, Schmid RM, Hebrok M, Roy N, Esposito I. PMID: 28473229; PMCID: PMC5770228.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017 Aug 15; 23(16):4865-4874. Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 28424202; PMCID: PMC5712228.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    34. Designing β Cells. Cell Metab. 2017 02 07; 25(2):223-224. Hebrok M. PMID: 28178560.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    35. All mixed up: defining roles for β-cell subtypes in mature islets. Genes Dev. 2017 02 01; 31(3):228-240. Liu JS, Hebrok M. PMID: 28270515; PMCID: PMC5358720.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    36. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Genes Dev. 2016 12 15; 30(24):2669-2683. Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC. PMID: 28087712; PMCID: PMC5238727.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    37. Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity. Diabetologia. 2017 01; 60(1):35-38. Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA. PMID: 27785529; PMCID: PMC5516264.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    38. Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity. PLoS One. 2016; 11(10):e0164714. Muñoz-Bravo JL, Flores-Martínez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA. PMID: 27736991; PMCID: PMC5063371.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    39. Human islets contain four distinct subtypes of β cells. Nat Commun. 2016 07 11; 7:11756. Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M. PMID: 27399229; PMCID: PMC4942571.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    40. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 05; 22(5):497-505. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. PMID: 27089513; PMCID: PMC4860133.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    41. p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia. Cancer Res. 2016 06 01; 76(11):3351-63. Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds AB, Goggins M, Younes M, Iacobuzio-Donahue CA, Leach SD, Bailey JM. PMID: 27032419; PMCID: PMC4891257.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    42. Life and death of β cells in Type 1 diabetes: A comprehensive review. J Autoimmun. 2016 07; 71:51-8. Wilcox NS, Rui J, Hebrok M, Herold KC. PMID: 27017348; PMCID: PMC4903951.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    43. A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells. Diabetes Obes Metab. 2016 Apr; 18(4):355-65. Saini C, Petrenko V, Pulimeno P, Giovannoni L, Berney T, Hebrok M, Howald C, Dermitzakis ET, Dibner C. PMID: 26662378.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    44. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016 Jan 06; 7:10080. Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. PMID: 26733021; PMCID: PMC4729817.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    45. Chapter 30 Development of the Endocrine Pancreas. Endocrinology: Adult and Pediatric. 2016 Jan 1; 517-526.e5. Hebrok HM, German GM. .
      View in: Publisher Site   Mentions:
    46. Regulation of Cellular Identity in Cancer. Dev Cell. 2015 Dec 21; 35(6):674-84. Roy N, Hebrok M. PMID: 26702828; PMCID: PMC4692359.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    47. β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1. Cell. 2015 Dec 03; 163(6):1457-67. Suriben R, Kaihara KA, Paolino M, Reichelt M, Kummerfeld SK, Modrusan Z, Dugger DL, Newton K, Sagolla M, Webster JD, Liu J, Hebrok M, Dixit VM. PMID: 26627735.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    48. Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation. Stem Cells Int. 2016; 2016:6183562. Russ HA, Landsman L, Moss CL, Higdon R, Greer RL, Kaihara K, Salamon R, Kolker E, Hebrok M. PMID: 26681951; PMCID: PMC4670689.
      View in: PubMed   Mentions: 8  
    49. Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification. Development. 2015 Dec 01; 142(23):4010-25. Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ. PMID: 26483210; PMCID: PMC4712832.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    50. DNA methylation directs functional maturation of pancreatic β cells. J Clin Invest. 2015 Jul 01; 125(7):2851-60. Dhawan S, Tschen SI, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A. PMID: 26098213; PMCID: PMC4563682.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
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    131. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer. 2003 Dec; 3(12):903-11. Pasca di Magliano M, Hebrok M. PMID: 14737121.
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    134. Hedgehog signaling in pancreas development. Mech Dev. 2003 Jan; 120(1):45-57. Hebrok M. PMID: 12490295.
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    135. Intercellular signals regulating pancreas development and function. Genes Dev. 2001 Jan 15; 15(2):111-27. Kim SK, Hebrok M. PMID: 11157769.
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    136. Regulation of pancreas development by hedgehog signaling. Development. 2000 Nov; 127(22):4905-13. Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA. PMID: 11044404.
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    137. Activin receptor patterning of foregut organogenesis. Genes Dev. 2000 Aug 01; 14(15):1866-71. Kim SK, Hebrok M, Li E, Oh SP, Schrewe H, Harmon EB, Lee JS, Melton DA. PMID: 10921901; PMCID: PMC316826.
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    138. CHAPTER 6 INDUCTIVE PHENOMENA. Principles of Tissue Engineering. 2000 Jan 1; 73-80. Hebrok HM, Melton MD. .
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    139. Screening for novel pancreatic genes expressed during embryogenesis. Diabetes. 1999 Aug; 48(8):1550-6. Hebrok M, Kim SK, Melton DA. PMID: 10426372.
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    142. Repression of muscle-specific gene activation by the murine Twist protein. Exp Cell Res. 1997 May 01; 232(2):295-303. Hebrok M, Füchtbauer A, Füchtbauer EM. PMID: 9168805.
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    143. Pancreas development in the chick embryo. Cold Spring Harb Symp Quant Biol. 1997; 62:377-83. Kim SK, Hebrok M, Melton DA. PMID: 9598372.
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    144. M-twist expression inhibits mouse embryonic stem cell-derived myogenic differentiation in vitro. Exp Cell Res. 1995 Sep; 220(1):92-100. Rohwedel J, Horák V, Hebrok M, Füchtbauer EM, Wobus AM. PMID: 7664846.
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    145. M-twist is an inhibitor of muscle differentiation. Dev Biol. 1994 Oct; 165(2):537-44. Hebrok M, Wertz K, Füchtbauer EM. PMID: 7958419.
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