Matthias Hebrok, PhD

Title(s)Professor, Diabetes Center
SchoolSchool of Medicine
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    Title(s)Director, Diabetes Center

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    Collapse Overview
    The main focus of my lab is to understand how islets of Langerhans, the endocrine component of the pancreas, are formed during organogenesis, how their function is regulated in the mature organism, and how changes in gene expression might allow islet regeneration. Islet cells, including glucagon-producing a- and insulin-producing ß-cells, regulate blood glucose homeostasis. The importance of the latter is highlighted by the fact that loss of ß-cells leads to type I diabetes mellitus. Conventional treatment of diabetic patients is based on insulin injections. Unfortunately, episodes of hypo- and hyperglycemia occur frequently and result in severe secondary complications, including coronary and microvascular diseases. Recent reports have shown that islet transplantation successfully restores glucose tolerance. However islets are in short supply, a dilemma that severely restricts the feasibility of large-scale therapy through islet transplantation. An alternative approach is the regeneration of ß- or islet cells from committed precursor cells and the majority of the projects in my lab are designed to unravel the program that directs an ordinary cell in the gut to become a ß-cell. Understanding of these processes will be crucial for future cell replacement strategies.

    Analysis of known signaling pathways: We employ knockout and transgenic mice lines to study the effect of known signaling pathways involved in cell proliferation, differentiation and migration on islet progenitor cells. In particular, we are interested in understanding how components of the Hedgehog and Wnt pathways influence pancreas development and endocrine cell differentiation. While previous studies have suggested an inhibitory role for members of the Hedgehog family, our recent results indicate that some Hedgehog signaling is required for pancreas formation. Currently, we are using a combination of knockout and transgenic approaches to determine if manipulations of the Hedgehog and Wnt pathways stimulate ß-cell development and function.

    Identification of novel pancreas/islet genes: In another set of experiments we have identified novel pancreatic genes via 'gene-trapping'. This technique allows to randomly trap and mark genes by inserting a target construct containing the bacterial LacZ gene into the DNA of embryonic stem (ES) cells. Trapped genes are identified by sequencing of amplified cDNA fragments (5' RACE) and mouse lines are established by blastocyst injection. The insertion of the gene-trap vector places the bacterial ß-galactosidase gene under control of the promoter of the trapped gene. Thus, the normal expression pattern of this gene can rapidly be visualized by staining for ß-galactosidase activity within any given tissue, including the pancreas. More importantly, vector insertion causes either null or severe hypomorphic mutations that reveal if the trapped gene is essential for pancreas and ß-cell differentiation. These studies are done in collaboration with Marc Tessier-Lavigne, Stanford University, who is interested in brain development and is generously providing mice for our analysis.

    Generation of ß-cells from adult progenitor cells: Recent studies have shown that adult organ stem cells have the ability to develop into a number of different tissues. We are taking advantage of our understanding of pancreas development and have started to investigate if adult progenitor cells have the potential to develop into insulin-producing ß-cells. Bone marrow derived stem cells are co-cultured with embryonic pancreas buds that develop into endocrine islets and thus provide the necessary signals for ß-cell differentiation. Initially, we focus on murine adult stem cells, but will include human cells as soon as the 'proof of principle' experiments have shown that murine cells can adopt pancreatic fates.

    Model systems for pancreatic cancer: Overt hedgehog signaling has been implicated in cancer formation in various tissues; however it has not been linked to the formation of pancreatic adenocarcinomas, an aggressive form of cancer that is virtually incurable. We have started collaboration with Martin McMahon's laboratory at the UCSF Cancer Center to show that deregulated Hedgehog signaling promotes proliferation of pancreatic cancer cell lines and if inhibition of Hedgehog signaling blocks cell proliferation. Currently, we are manipulating the Hedgehog pathway in pancreatic tissue of transgenic animals to address the tumorigenic activity of this pathway in vivo.

    Collapse Research 
    Collapse Research Activities and Funding
    Real-time intracellular monitoring of microRNAs in human stem cell-derived insulin producing organoids
    NIH R43DK130034Sep 6, 2021 - Aug 31, 2022
    Role: Co-Principal Investigator
    Modulating intrinsic beta cell stress to block diabetes pathogenesis
    NIH R01DK129935Aug 15, 2021 - Jun 30, 2025
    Role: Principal Investigator
    Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systems
    NIH U01DK123559Sep 20, 2019 - May 31, 2023
    Role: Co-Principal Investigator
    Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes Mellitus
    NIH UH3DK120004Sep 20, 2018 - Jul 31, 2023
    Role: Co-Principal Investigator
    Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes Mellitus
    NIH UG3DK120004Sep 20, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH U01DK107383Jul 1, 2016 - Dec 31, 2020
    Role: Co-Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH/NIDDK R01DK107383Jul 1, 2016 - Jun 30, 2020
    Role: Co-Principal Investigator
    Mechanisms of beta cell maturation
    NIH R01DK108666Sep 30, 2015 - Jul 31, 2019
    Role: Principal Investigator
    Regulation of beta cell identity and dedifferentiation
    NIH R01DK105831May 1, 2015 - Jul 31, 2023
    Role: Principal Investigator
    Epigenetic regulation of pancreatic cancer
    NIH R01CA172045Apr 3, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Defining the role of MafA in islet beta cells
    NIH R01DK090570Jul 29, 2011 - May 31, 2026
    Role: Co-Principal Investigator
    Expanding beta-cell mass
    NIH U01DK089541Sep 15, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Embryonic signaling pathways in pancreatic cancer
    NIH R01CA112537Sep 1, 2004 - Nov 30, 2015
    Role: Principal Investigator
    Diabetes Research Center
    NIH P30DK063720Sep 1, 2002 - Mar 31, 2021
    Role: Co-Investigator
    Effects of Hedgehog Signaling on Pancreas Organogenesis
    NIH R01DK060533Dec 1, 2001 - Feb 28, 2014
    Role: Principal Investigator
    Molecular Control of Pancreatic Islet Development
    NIH U19DK061245Sep 30, 2001 - Jul 31, 2006
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2024 Mar; 30(3):908. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. PMID: 38017076.
      View in: PubMed   Mentions:    Fields:    
    2. KRAS degradation averts PDAC chemoresistance. Nat Cancer. 2024 Mar; 5(3):375-377. Leonhardt L, Hebrok M. PMID: 38538908.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Sox9 regulates alternative splicing and pancreatic beta cell function. Nat Commun. 2024 Jan 18; 15(1):588. Puri S, Maachi H, Nair G, Russ HA, Chen R, Pulimeno P, Cutts Z, Ntranos V, Hebrok M. PMID: 38238288; PMCID: PMC10796970.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma. Cancer Research. 2024 Jan 16; 84(2_Supplement):a046-a046. Hendley HA, Urano UA, Peng PX, Ashe AS, Phu PT, Ng NM, Kerper KN, Berrios BD, Lee LJ, Jin JD, Jang JG, Gbenedio GO, Roose RJ, Yeh YJ, Gallinger GS, Biankin BA, Ntranos NV, Chang CD, Dawson DD, Kim KG, Weaver WV, Raffai RR, Hebrok HM. .
      View in: Publisher Site   Mentions:
    5. Stem cell-derived islet therapy: is this the end of the beginning? Nat Rev Endocrinol. 2023 Dec; 19(12):681-682. Cochrane VA, Hebrok M. PMID: 37783847.
      View in: PubMed   Mentions: 1     Fields:    
    6. Role of Cell-Based Therapies in T2D. Semin Nephrol. 2023 05; 43(3):151432. Ashe S, Hebrok M. PMID: 37918206.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity. JCI Insight. 2023 08 22; 8(16). Cha J, Tong X, Walker EM, Dahan T, Cochrane VA, Ashe S, Russell R, Osipovich AB, Mawla AM, Guo M, Liu JH, Loyd ZA, Huising MO, Magnuson MA, Hebrok M, Dor Y, Stein R. PMID: 37606041; PMCID: PMC10543725.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Loss of ZNF148 enhances insulin secretion in human pancreatic β cells. JCI Insight. 2023 06 08; 8(11). de Klerk E, Xiao Y, Emfinger CH, Keller MP, Berrios DI, Loconte V, Ekman AA, White KL, Cardone RL, Kibbey RG, Attie AD, Hebrok M. PMID: 37288664; PMCID: PMC10393241.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space. Bioeng Transl Med. 2023 Jul; 8(4):e10520. Chendke GS, Kharbikar BN, Ashe S, Faleo G, Sneddon JB, Tang Q, Hebrok M, Desai TA. PMID: 37476069; PMCID: PMC10354771.
      View in: PubMed   Mentions: 1  
    10. Minimal SC-ß-Cell Properties for Transplantation in Diabetic Patients. Pluripotent Stem Cell Therapy for Diabetes. 2023 Jan 1; 529-545. Cochrane CV, Xiao XY, Maachi MH, Hebrok HM. .
      View in: Publisher Site   Mentions:
    11. Abstract C051: Ceramide signaling regulates PDA aggression through exosome reprogramming of the stroma. Cancer Research. 2022 Nov 15; 82(22_Supplement):c051-c051. Hendley HA, Urano UA, Peng PX, Ashe AS, Kerper KN, Phu PT, Ng NM, Giacometti GS, Berrios BD, Jang JG, Yeh YJ, Gallinger GS, Chang CD, Biankin BA, Weaver WV, Kim KG, Dawson DD, Raffai RR, Hebrok HM. .
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    12. Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells. Lab Chip. 2022 Nov 08; 22(22):4430-4442. Goswami I, de Klerk E, Carnese P, Hebrok M, Healy KE. PMID: 36305868; PMCID: PMC9642094.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Pancreatic β-Cell Development and Regeneration. Cold Spring Harb Perspect Biol. 2022 05 27; 14(5). Kerper N, Ashe S, Hebrok M. PMID: 34580120; PMCID: PMC9159263.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses. JCI Insight. 2022 05 23; 7(10). Emfinger CH, de Klerk E, Schueler KL, Rabaglia ME, Stapleton DS, Simonett SP, Mitok KA, Wang Z, Liu X, Paulo JA, Yu Q, Cardone RL, Foster HR, Lewandowski SL, Perales JC, Kendziorski CM, Gygi SP, Kibbey RG, Keller MP, Hebrok M, Merrins MJ, Attie AD. PMID: 35603790; PMCID: PMC9220824.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus. Hum Gene Ther. 2022 08; 33(15-16):789-800. Chai S, Kim Y, Galivo F, Dorrell C, Wakefield L, Posey J, Ackermann AM, Kaestner KH, Hebrok M, Grompe M. PMID: 35297680; PMCID: PMC9419973.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells. Stem Cell Reports. 2022 04 12; 17(4):979-992. Parent AV, Ashe S, Nair GG, Li ML, Chavez J, Liu JS, Zhong Y, Streeter PR, Hebrok M. PMID: 35245441; PMCID: PMC9023773.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    17. Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation. Commun Biol. 2021 11 17; 4(1):1298. Heller S, Li Z, Lin Q, Geusz R, Breunig M, Hohwieler M, Zhang X, Nair GG, Seufferlein T, Hebrok M, Sander M, Julier C, Kleger A, Costa IG. PMID: 34789845; PMCID: PMC8599846.
      View in: PubMed   Mentions: 11  Translation:HumansCells
    18. Abstract PR-008: Kdm6 demethylases are critical regulators of pancreatic cancer initiation, progression and subtype specification. Cancer Research. 2021 Nov 15; 81(22_Supplement):pr-008-pr-008. Leonhardt LL, Li LL, Berrios BD, Ashe AS, Hendley HA, Kim KG, Hebrok HM. .
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    19. Mutations and variants of ONECUT1 in diabetes. Nat Med. 2021 11; 27(11):1928-1940. Philippi A, Heller S, Costa IG, Senée V, Breunig M, Li Z, Kwon G, Russell R, Illing A, Lin Q, Hohwieler M, Degavre A, Zalloua P, Liebau S, Schuster M, Krumm J, Zhang X, Geusz R, Benthuysen JR, Wang A, Chiou J, Gaulton K, Neubauer H, Simon E, Klein T, Wagner M, Nair G, Besse C, Dandine-Roulland C, Olaso R, Deleuze JF, Kuster B, Hebrok M, Seufferlein T, Sander M, Boehm BO, Oswald F, Nicolino M, Julier C, Kleger A. PMID: 34663987; PMCID: PMC9356324.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    20. Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection. Cell Rep. 2021 08 17; 36(7):109538. Parent AV, Faleo G, Chavez J, Saxton M, Berrios DI, Kerper NR, Tang Q, Hebrok M. PMID: 34407395.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    21. Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications. J Biomed Mater Res A. 2021 12; 109(12):2438-2448. Shaheen R, Gurlin RE, Gologorsky R, Blaha C, Munnangi P, Santandreu A, Torres A, Carnese P, Nair GG, Szot G, Fissell WH, Hebrok M, Roy S. PMID: 34196100.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. Elife. 2021 05 19; 10. Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, Hebrok M. PMID: 34009124; PMCID: PMC8184217.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    23. Stem Cell-Based Clinical Trials for Diabetes Mellitus. Front Endocrinol (Lausanne). 2021; 12:631463. de Klerk E, Hebrok M. PMID: 33716982; PMCID: PMC7953062.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    24. Non-xenogeneic expansion and definitive endoderm differentiation of human pluripotent stem cells in an automated bioreactor. Biotechnol Bioeng. 2021 02; 118(2):979-991. Jacobson EF, Chen Z, Stoukides DM, Nair GG, Hebrok M, Tzanakakis ES. PMID: 33205831.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    25. Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy. Nat Rev Endocrinol. 2020 09; 16(9):506-518. Nair GG, Tzanakakis ES, Hebrok M. PMID: 32587391; PMCID: PMC9188823.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    26. Loss of the transcription factor MAFB limits β-cell derivation from human PSCs. Nat Commun. 2020 06 02; 11(1):2742. Russell R, Carnese PP, Hennings TG, Walker EM, Russ HA, Liu JS, Giacometti S, Stein R, Hebrok M. PMID: 32488111; PMCID: PMC7265500.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    27. LIN28B Impairs the Transition of hESC-Derived β Cells from the Juvenile to Adult State. Stem Cell Reports. 2020 01 14; 14(1):9-20. Zhou X, Nair GG, Russ HA, Belair CD, Li ML, Shveygert M, Hebrok M, Blelloch R. PMID: 31883920; PMCID: PMC6962644.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    28. Abstract C20: Smpd3 augments chemotherapy and thwarts PDA progression. Cancer Research. 2019 Dec 13; 79(24_Supplement):c20-c20. Hendley HA, Urano UA, Kerper KN, Duong DP, Bailey BP, Chang CD, Biankin BA, Dawson DD, Kim KG, Raffai RR, Hebrok HM. .
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    29. Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health. Diabetes. 2020 03; 69(3):342-354. Tong X, Dai C, Walker JT, Nair GG, Kennedy A, Carr RM, Hebrok M, Powers AC, Stein R. PMID: 31836690; PMCID: PMC7034188.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    30. Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors. JCI Insight. 2019 11 14; 4(22). Pekrun K, De Alencastro G, Luo QJ, Liu J, Kim Y, Nygaard S, Galivo F, Zhang F, Song R, Tiffany MR, Xu J, Hebrok M, Grompe M, Kay MA. PMID: 31723052; PMCID: PMC6948855.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    31. Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids. Adv Biosyst. 2019 Sep; 3(9). Chendke GS, Faleo G, Juang C, Parent AV, Bernards DA, Hebrok M, Tang Q, Desai TA. PMID: 31633004; PMCID: PMC6800235.
      View in: PubMed   Mentions: 5     Fields:    
    32. mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes. J Clin Invest. 2019 07 02; 129(10):4124-4137. Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A. PMID: 31265435; PMCID: PMC6763225.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    33. The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function. Diabetes. 2019 09; 68(9):1806-1818. Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, Wright CVE, Stein R. PMID: 31201281; PMCID: PMC6702633.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    34. Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells. Nat Cell Biol. 2019 06; 21(6):792. Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M. PMID: 30914825.
      View in: PubMed   Mentions: 4     Fields:    
    35. Pancreatic pericytes originate from the embryonic pancreatic mesenchyme. Dev Biol. 2019 05 01; 449(1):14-20. Harari N, Sakhneny L, Khalifa-Malka L, Busch A, Hertel KJ, Hebrok M, Landsman L. PMID: 30771302; PMCID: PMC9728144.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Rapid generation of functional mature pancreatic islet-beta cells from human pluripotent stem cells. Protocol Exchange. 2019 Feb 4. Nair NG, Nair NG, Russ RH, Hebrok HM. .
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    37. Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells. Nat Cell Biol. 2019 02; 21(2):263-274. Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M. PMID: 30710150; PMCID: PMC6746427.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    38. The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis. J Clin Invest. 2018 08 01; 128(8):3475-3489. Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H. PMID: 30010625; PMCID: PMC6063489.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    39. Co-Transplant of Parathyroid Gland and Stem Cell-Derived Insulin-Producing Cells Enhances Graft Survival through Release of Pro-Angiogenic and Pro-Survival Factors. Transplantation Journal. 2018 Jul 1; 102(&NA;):s350. Faleo FG, Ward WC, Parent PA, Nair NG, Chang CW, Stock SP, Hebrok HM, Tang TQ. .
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    40. Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell. 2018 Jun 01; 22(6):810-823. Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M. PMID: 29859172; PMCID: PMC6007036.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    41. Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev Cell. 2018 05 07; 45(3):347-361.e5. Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G. PMID: 29656931; PMCID: PMC5962294.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    42. Replication confers β cell immaturity. Nat Commun. 2018 02 02; 9(1):485. Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M. PMID: 29396395; PMCID: PMC5797102.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    43. Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. Stem Cell Reports. 2017 09 12; 9(3):807-819. Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q. PMID: 28803916; PMCID: PMC5599226.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    44. Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy. ACS Nano. 2017 08 22; 11(8):7747-7757. Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA. PMID: 28763191; PMCID: PMC5667644.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    45. Corticotropin-releasing hormone type 2 receptor deficiency impairs pancreatic function in a sex-specific manner. Pancreatology. 2017 Jul 1; 17(3):s8. Bhargava BA, Hagiwara HS, Puri PS, Hebrok HM, Szot SG, Hasdemir HB, Paruthiyil PS. .
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    46. Atypical flat lesions derive from pancreatic acinar cells. Pancreatology. 2017 May - Jun; 17(3):350-353. von Figura G, Fahrenkrog-Petersen L, Hidalgo-Sastre A, Hartmann D, Hüser N, Schmid RM, Hebrok M, Roy N, Esposito I. PMID: 28473229; PMCID: PMC5770228.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    47. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017 Aug 15; 23(16):4865-4874. Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 28424202; PMCID: PMC5712228.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    48. Global Protease Activity Profiling Provides Differential Diagnosis of Cystic Precursor Lesions of Pancreatic Cancer. The FASEB Journal. 2017 Apr 1; 31(S1). Ivry IS, Dominguez DD, Roy RN, Hatcher HS, Hebrok HM, Kim KG, O'Donoghue OA, Kirkwood KK, Craik CC. .
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    49. Designing β Cells. Cell Metab. 2017 02 07; 25(2):223-224. Hebrok M. PMID: 28178560.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    50. All mixed up: defining roles for β-cell subtypes in mature islets. Genes Dev. 2017 02 01; 31(3):228-240. Liu JS, Hebrok M. PMID: 28270515; PMCID: PMC5358720.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
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