Megan Mayerle, PhD

TitlePostdoctoral Scholar
InstitutionUniversity of California San Francisco
DepartmentBiochemistry and Biophysics
Address600 16th St
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    The Johns Hopkins UniversityPhD2012Biology
    Marquette UniversityBS2004Biology and English Literature
    Collapse Awards and Honors
    University of California San Francisco2016  - 2016RNA Society Travel Award
    Johns Hopkins University2009  - 2010Deans Teaching Fellowship
    Marquette University2004Alpha Sigma Nu Membership
    Johns Hopkins University2010  - 2010Graduate Representative Organization Travel Grant
    Marquette University2000  - 2004Ignatius Scholarship

    Collapse Overview 
    Collapse Overview
    Cells have developed elaborate mechanisms to minimize errors in gene expression. These fall into two broad categories: 1) fidelity mechanisms intrinsic to the gene expression machinery that minimize errors during transcription, RNA pro-cessing, and translation, and 2) surveillance mechanisms that scan the products of the gene expression machinery for errors and correct them. I am broadly interested the mechanistic basis of how the components of the large, RNA-protein complexes involved in gene expression maintain fidelity, and how aberrant versions of these complexes can cause and contribute to human diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Spliceosome Activation at the Single Molecule Level: Insight from Disease Alleles
    NIH F32GM109512Sep 1, 2014 - Aug 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. MacRae AJ, Mayerle M, Hrabeta-Robinson E, Chalkley RJ, Guthrie C, Burlingame AL, Jurica M. Prp8 positioning of U5 snRNA is linked to 5' splice site recognition. RNA. 2018 Feb 27. PMID: 29487104.
      View in: PubMed
    2. Mayerle M, Raghavan M, Ledoux S, Price A, Stepankiw N, Hadjivassiliou H, Moehle EA, Mendoza SD, Pleiss JA, Guthrie C, Abelson J. Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):4739-4744. PMID: 28416677.
      View in: PubMed
    3. Mayerle M, Guthrie C. Genetics and biochemistry remain essential in the structural era of the spliceosome. Methods. 2017 Aug 01; 125:3-9. PMID: 28132896.
      View in: PubMed
    4. Mayerle M, Guthrie C. Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing. RNA. 2016 May; 22(5):793-809. PMID: 26968627; PMCID: PMC4836653 [Available on 05/01/17].
    5. Mayerle M, Guthrie C. A new communication hub in the RNA world. Nat Struct Mol Biol. 2016 Mar; 23(3):189-90. PMID: 26931416.
      View in: PubMed
    6. Kim H, Abeysirigunawarden SC, Chen K, Mayerle M, Ragunathan K, Luthey-Schulten Z, Ha T, Woodson SA. Protein-guided RNA dynamics during early ribosome assembly. Nature. 2014 Feb 20; 506(7488):334-8. PMID: 24522531; PMCID: PMC3968076.
    7. Mayerle M, Woodson SA. Specific contacts between protein S4 and ribosomal RNA are required at multiple stages of ribosome assembly. RNA. 2013 Apr; 19(4):574-85. PMID: 23431409; PMCID: PMC3677267.
    8. Chen K, Eargle J, Lai J, Kim H, Abeysirigunawardena S, Mayerle M, Woodson S, Ha T, Luthey-Schulten Z. Assembly of the five-way junction in the ribosomal small subunit using hybrid MD-Go simulations. J Phys Chem B. 2012 Jun 14; 116(23):6819-31. PMID: 22458631; PMCID: PMC3422213.
    9. Mayerle M, Bellur DL, Woodson SA. Slow formation of stable complexes during coincubation of minimal rRNA and ribosomal protein S4. J Mol Biol. 2011 Sep 23; 412(3):453-65. PMID: 21821049; PMCID: PMC3167742.
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