Meghna Gupta, PhD

Title(s)Specialist, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th St, #S414
San Francisco CA 94158
Phone415-476-3937
Emailmeghna.gupta@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco, San Francisco, CA, USASpecialist-Structural Biology
    University of California San Francisco, San Francisco, CA, USAPostdoc07/2021Structural Biology
    Jawaharlal Nehru University, Delhi, IndiaPhD02/2016Biochemistry and Biophysics
    Jawaharlal Nehru University, Delhi, IndiaMSc07/2010Biochemistry and Biophysics
    University of Delhi, Delhi, IndiaBSc07/2008Life Sciences
    Collapse Awards and Honors
    National Institute on Aging2022  - -NIH K99/R00 Pathway to Independence
    Leading Edge Program2022Leading Edge Fellow
    American Heart Association2021  - 2022AHA postdoctoral fellowship

    Collapse Overview 

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Smart data collection for CryoEM. Journal of Structural Biology. 2022; 4(214). Bepler, T. Borst, A. J. Bouvette, J. Cannone, G. Chen, S. Cheng, A. Cheng, A. Fan, Q. Grollios, F. Gupta, H. Gupta, M. Humphreys, T. Kim, P. T. Kuang, H. Li, Y. Noble, A. J. Punjani, A. Rice, W. J. Sorzano, C. O. S. Stagg, S. M. Strauss, J. Yu, L. Carragher, B. Potter, C. S. View Publication.
    2. Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2. Cell Rep. 2022 07 19; 40(3):111088. Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, Krogan N, Fujimori DG, Ott M. PMID: 35839775; PMCID: PMC9234021.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    3. Fun30 and Rtt109 Mediate Epigenetic Regulation of the DNA Damage Response Pathway in C. albicans. J Fungi (Basel). 2022 May 25; 8(6). Maurya PK, Garai P, Goel K, Bhatt H, Dutta A, Goyal A, Dewasthale S, Gupta M, Haokip DT, Barik S, Muthuswami R. PMID: 35736042; PMCID: PMC9225650.
      View in: PubMed   Mentions:
    4. Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc Natl Acad Sci U S A. 2022 03 01; 119(9). Dickinson MS, Lu J, Gupta M, Marten I, Hedrich R, Stroud RM. PMID: 35210362; PMCID: PMC8892357.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    5. Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel. Biochemistry. 2022 10 18; 61(20):2177-2181. Dickinson MS, Pourmal S, Gupta M, Bi M, Stroud RM. PMID: 34964607; PMCID: PMC9931035.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2. bioRxiv. 2021 Nov 15. Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Carlson-Stevermer J, Gupta M, Zhang MY, Soveg FW, Hayashi JM, Taha TY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, QCRG Structural Biology Consortium, Krogan N, Galonic Fujimori D, Ott M. PMID: 34816261; PMCID: PMC8609896.
      View in: PubMed   Mentions: 2  
    7. Symmetry reduction in a hyperpolarization-activated homotetrameric ion channel. bioRxiv. 2021; (2021.09.20). Miles Sasha Dickinson, Meghna Gupta, Sergei A Pourmal, Maxine Bi, Robert M Stroud. View Publication.
    8. RTT109 and Fun30 proteins mediate epigenetic regulation of the DNA damage response pathway in C. albicans. bioRxiv. 2021; (2021.07.22). Pramita Garai, Prashant Kumar Maurya, Himanshu Bhatt, Aarti Goyal, Sakshi Dewasthale, Meghna Gupta, Dominic Thangminlen Haokip, Rohini Muthuswami. View Publication.
    9. Key computational findings reveal proton transfer as driving the functional cycle in the phosphate transporter PiPT. Proc Natl Acad Sci U S A. 2021 06 22; 118(25). Liu Y, Li C, Gupta M, Verma N, Johri AK, Stroud RM, Voth GA. PMID: 34135124; PMCID: PMC8237618.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
      View in: PubMed   Mentions:
    11. Highlighting membrane protein structure and function: A celebration of the Protein Data Bank. J Biol Chem. 2021 Jan-Jun; 296:100557. Li F, Egea PF, Vecchio AJ, Asial I, Gupta M, Paulino J, Bajaj R, Dickinson MS, Ferguson-Miller S, Monk BC, Stroud RM. PMID: 33744283; PMCID: PMC8102919.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    12. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 12 18; 370(6523):1473-1479. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 33154106; PMCID: PMC7857409.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    13. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020; (eabe3255). Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M; QCRG Structural Biology Consortium, Walter P, Manglik A. View Publication.
    14. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, et al. PMID: 33060197; PMCID: PMC7808408.
      View in: PubMed   Mentions: 280     Fields:    Translation:HumansCells
    15. An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation. bioRxiv. 2020 Aug 17. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 32817938; PMCID: PMC7430568.
      View in: PubMed   Mentions: 1  
    16. Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. Elife. 2019 05 31; 8. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. PMID: 31149896; PMCID: PMC6588346.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    17. Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast. Antimicrob Agents Chemother. 2019 03; 63(3). Khandelwal NK, Wasi M, Nair R, Gupta M, Kumar M, Mondal AK, Gaur NA, Prasad R. PMID: 30642932; PMCID: PMC6395933.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    18. Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling. J Biol Chem. 2018 01 12; 293(2):412-432. Khandelwal NK, Chauhan N, Sarkar P, Esquivel BD, Coccetti P, Singh A, Coste AT, Gupta M, Sanglard D, White TC, Chauvel M, d'Enfert C, Chattopadhyay A, Gaur NA, Mondal AK, Prasad R. PMID: 29158264; PMCID: PMC5767851.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    19. Ligand-induced conformation changes drive ATP hydrolysis and function in SMARCAL1. FEBS J. 2015 Oct; 282(19):3841-59. Gupta M, Mazumder M, Dhatchinamoorthy K, Nongkhlaw M, Haokip DT, Gourinath S, Komath SS, Muthuswami R. PMID: 26195148.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. Motifs Q and I are required for ATP hydrolysis but not for ATP binding in SWI2/SNF2 proteins. Biochemistry. 2012 May 08; 51(18):3711-22. Nongkhlaw M, Gupta M, Komath SS, Muthuswami R. PMID: 22510062.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
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