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Mekhail Anwar, MD, PhD

Address1600 Divisadero, Cancer Cntr
San Francisco CA 94115
Phone415-514-3629
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    Collapse Education and Training
    University of California, San FranciscoM.D. Medicine
    Massachusetts Institute of TechnologyPh.D.Electrical Engineering and Computer Sciences
    University of California, BerkeleyMSElectrical Engineering and Computer Sciences

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    Collapse Overview
    Mekhail Anwar, M.D., Ph.D., is an Assistant Professor in the Department of Radiation Oncology at the University of California, San Francisco, with expertise in electrical engineering focusing on integrated circuits and micro-fabricated sensors for cancer imaging with a clinical practice in Radiation Oncology specializing in the multimodality treatment of malignancies using focal, targeted radiation therapy.

    Dr. Anwar has over 13 years of experiences developing micro-fabricated devices for biomedical applications. Educated at UC Berkeley in Physics, where he was awarded the University Medal as the top graduating senior, he completed his medical degree at UC San Francisco, and went to the Massachusetts Institute of Technology where his Ph.D. in electrical engineering focused on using micro-fabricated devices and integrated circuits for biological detection. He has several first author publications spanning integrated circuits, imaging, and protein arrays. His clinical interest in oncology is using new techniques in imaging to guide therapeutic intervention, and he has clinical research efforts in, pancreatic, liver and prostate cancer as well as glioblastoma. His research focus is fundamentally guided by where innovations in diagnostic and treatment technologies can most benefit patient care.

    Research Focus

    The primary focus of his laboratory is to identify where gaps in diagnostic information and therapeutic tools compromise patient care, and develop tools to solve these problems, with an emphasis on sensing in the tumor microenvironment. Acutely aware of their limitation in spatially identifying microscopic disease, Dr. Anwar's solution is to embed sensors directly within the tumor and the neighboring microenvironment, to achieve increased sensitivity, guiding precise, focal therapy to enhance the efficacy of current treatments while mitigating toxicity. His work synergistically incorporates biological approaches with integrated circuit and micro-fabricated technologies, leveraging the advantages of biological systems (interface, detection, synthesis and release of ligands, etc.) with those of electronics (computation, analysis, communication and actuation) to solve problems in therapeutic and diagnostic oncology. This has the potential to introduce new curative paradigms in breast cancer therapy, as current imaging technology, both for staging, treatment planning and surveillance is limited to large foci of disease, and true microscopic metastasis and recurrence, which is potentially curable, often goes undetected.


    Collapse Research 
    Collapse Research Activities and Funding
    An Interferometric CMOS DC-­-Terahertz Lab on a Chip Biosensor
    National Science Foudnation 1608958Jun 1, 2016 - May 29, 2019
    Role: Co-Principle Investigator
    The Development of a microfabricated Fluorescent Imager for Real-­- Time, Intraoperative Imaging of Microscopic Residual Disease in Breast Cancer
    Mary Kay Ash Foundation P0506430Jul 1, 2015 - Jun 30, 2017
    Role: Principle Investigator
    Identification of Microscopic Residual Disease in Prostate Cancer using in-­- vivo Microfabricated Sensors and Targeted Biologics
    UCSF Research Allocation Program Mar 1, 2015 - Jul 1, 2016
    Role: Principle Investigator
    Development of a Real-­-Time Intraoperative Fluorescent Imager for Microscopic Residual Tumor
    National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through the UCSF Clinical and Translational Science Institute (CTSI) UL1 TR000004 (Parent Grant)Apr 1, 2013 - Jun 1, 2015
    Role: Co-Principle Investigator
    Identification and Treatment of Microscopic Residual and Recurrent Disease in Prostate Cancer Using in Vivo Microfabricated Sensors and Targeted Biologics
    Department of Defense PC141609Oct 1, 2005 - Sep 30, 2019
    Role: Principle Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wahl M, Anwar M, Hess CP, Chang SM, Lupo JM. Relationship between radiation dose and microbleed formation in patients with malignant glioma. Radiat Oncol. 2017 Aug 10; 12(1):126. PMID: 28797254.
      View in: PubMed
    2. Anwar M, Molinaro AM, Morin O, Chang SM, Haas-Kogan DA, Nelson SJ, Lupo JM. Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017 Sep; 188(3):303-313. PMID: 28723274.
      View in: PubMed
    3. Paulsson AK, Yom SS, Anwar M, Pinnaduwage D, Sudhyadhom A, Gottschalk AR, Chang AJ, Descovich M. Respiration-Induced Intraorgan Deformation of the Liver. Technol Cancer Res Treat. 2017 Jan 01; 1533034616687193. PMID: 28071340.
      View in: PubMed
    4. Anwar M, Yu Y, Glastonbury CM, El-Sayed IH, Yom SS. Delineation of radiation therapy target volumes for cutaneous malignancies involving the ophthalmic nerve (cranial nerve V-1) pathway. Pract Radiat Oncol. 2016 Nov - Dec; 6(6):e277-e281. PMID: 27687189.
      View in: PubMed
    5. Anwar M, Weinberg V, Seymour Z, Hsu IJ, Roach M, Gottschalk AR. Outcomes of hypofractionated stereotactic body radiotherapy boost for intermediate and high-risk prostate cancer. Radiat Oncol. 2016 Jan 21; 11:8. PMID: 26792201; PMCID: PMC4721063.
    6. Fogh S, Wahl M, Anwar M, Haas-Kogan D, Clarke JL, Sneed PK. Standardization and quality assurance of radiation therapy volumes for adults with high-grade gliomas. Semin Radiat Oncol. 2014 Oct; 24(4):259-64. PMID: 25219810.
      View in: PubMed
    7. Anwar M, Weinberg V, Chang AJ, Hsu IC, Roach M, Gottschalk A. Hypofractionated SBRT versus conventionally fractionated EBRT for prostate cancer: comparison of PSA slope and nadir. Radiat Oncol. 2014 Feb 02; 9:42. PMID: 24484652; PMCID: PMC3923240.
    8. Anwar M, Westphalen AC, Jung AJ, Noworolski SM, Simko JP, Kurhanewicz J, Roach M, Carroll PR, Coakley FV. Role of endorectal MR imaging and MR spectroscopic imaging in defining treatable intraprostatic tumor foci in prostate cancer: quantitative analysis of imaging contour compared to whole-mount histopathology. Radiother Oncol. 2014 Feb; 110(2):303-8. PMID: 24444524; PMCID: PMC3969841.
    9. Anwar M, Barani IJ. Role of stereotactic body radiotherapy in spinal metastasis and subsequent fracture risk: identifying and treating the at-risk patient. CNS Oncol. 2013 Sep; 2(5):437-45. PMID: 25054666.
      View in: PubMed
    10. Anwar M, Gupta PB, Palaniapan R, Matsudaira P. Protein array patterning by diffusive gel stamping. PLoS One. 2012; 7(10):e46382. PMID: 23071560; PMCID: PMC3468578.
    11. Coakley FV, Anwar M, Poder L, Wang ZJ, Yeh BM, Joe BN. Magnetic resonance imaging of massive ovarian edema in pregnancy. J Comput Assist Tomogr. 2010 Nov-Dec; 34(6):865-7. PMID: 21084901.
      View in: PubMed
    12. Anwar, M., Aytur, T., Matsudaira, P. Applied Physics Letters. A Wireless-Compatible CMOS-Based Optics-Free Microarray Imager. 2009; 94.
    13. Aytur T, Foley J, Anwar M, Boser B, Harris E, Beatty PR. A novel magnetic bead bioassay platform using a microchip-based sensor for infectious disease diagnosis. J Immunol Methods. 2006 Jul 31; 314(1-2):21-9. PMID: 16842813.
      View in: PubMed
    14. M Anwar, I Rousso. Applied Physics Letters. Atomic force microscopy with time resolution of microseconds. 2005; 86(1):014101-014101-3.
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