Mekhail Anwar, MD, PhD
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Title(s) | Associate Professor, Radiation Oncology |
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School | School of Medicine |
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Phone | 415-514-2070 |
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vCard | Download vCard |
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Biography University of California, San Francisco | M.D. | | Medicine | Massachusetts Institute of Technology | Ph.D. | | Electrical Engineering and Computer Sciences | University of California, Berkeley | MS | | Electrical Engineering and Computer Sciences |
National Institutes of Health | 2019 | | NIH Trailblazer Award | American Association for Cancer Research | 2019 | | AACR-Novocure Career Development Award | Department of Defense | 2015 | | Prostate Cancer Research Program Physician Research Training Award | American Society of Clinical Oncology | 2014 | | ASCO Young Investigator Award | Whitaker Foundation | | | Whitaker Fellowship in Biomedical Engineering | Department of Defense | | | National Defense Science and Engineering Fellowship | Radiological Society of North America | | | Roentgen Resident Research Award, | UC San Francisco | | | CTSI T1 Catalyst Award Grant | UC Berkeley | | | University Medal | UC San Francisco Cancer Center | 2016
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| 2017 | Give Breast Cancer the Boot Award | National Science Foundation | | | NSF Graduate Fellowship | UC San Francisco | 2017
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| 2018 | The Cancer League Award |
Overview Mekhail Anwar, M.D., Ph.D., is an Assistant Professor in the Department of Radiation Oncology at the University of California, San Francisco, with expertise in electrical engineering focusing on integrated circuits and micro-fabricated sensors for cancer imaging with a clinical practice in Radiation Oncology specializing in the multimodality treatment of malignancies using focal, targeted radiation therapy.
Dr. Anwar has over 13 years of experiences developing micro-fabricated devices for biomedical applications. Educated at UC Berkeley in Physics, where he was awarded the University Medal as the top graduating senior, he completed his medical degree at UC San Francisco, and went to the Massachusetts Institute of Technology where his Ph.D. in electrical engineering focused on using micro-fabricated devices and integrated circuits for biological detection. He has several first author publications spanning integrated circuits, imaging, and protein arrays. His clinical interest in oncology is using new techniques in imaging to guide therapeutic intervention, and he has clinical research efforts in, pancreatic, liver and prostate cancer as well as glioblastoma. His research focus is fundamentally guided by where innovations in diagnostic and treatment technologies can most benefit patient care.
Research Focus
The primary focus of his laboratory is to identify where gaps in diagnostic information and therapeutic tools compromise patient care, and develop tools to solve these problems, with an emphasis on sensing in the tumor microenvironment. Acutely aware of their limitation in spatially identifying microscopic disease, Dr. Anwar's solution is to embed sensors directly within the tumor and the neighboring microenvironment, to achieve increased sensitivity, guiding precise, focal therapy to enhance the efficacy of current treatments while mitigating toxicity. His work synergistically incorporates biological approaches with integrated circuit and micro-fabricated technologies, leveraging the advantages of biological systems (interface, detection, synthesis and release of ligands, etc.) with those of electronics (computation, analysis, communication and actuation) to solve problems in therapeutic and diagnostic oncology. This has the potential to introduce new curative paradigms in breast cancer therapy, as current imaging technology, both for staging, treatment planning and surveillance is limited to large foci of disease, and true microscopic metastasis and recurrence, which is potentially curable, often goes undetected.
Research ORNG Applications Bibliographic
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Factors Impacting Differential Outcomes in the Definitive Radiation Treatment of Anal Cancer Between HIV-Positive and HIV-Negative Patients. Oncologist. 2020 Sep; 25(9):772-779.
Susko M, Wang CJ, Lazar AA, Kim S, Laffan A, Feng M, Ko A, Venook AP, Atreya CE, Van Loon K, Anwar M. PMID: 32390297.
View in: PubMed Mentions: Fields:
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Signal to Noise Ratio as a Cross-Platform Metric for Intraoperative Fluorescence Imaging. Mol Imaging. 2020 Jan-Dec; 19:1536012120913693.
Gharia A, Papageorgiou EP, Giverts S, Park C, Anwar M. PMID: 32238038.
View in: PubMed Mentions: Fields:
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Chip-Scale Angle-Selective Imager for In Vivo Microscopic Cancer Detection. IEEE Trans Biomed Circuits Syst. 2020 02; 14(1):91-103.
Papageorgiou EP, Boser BE, Anwar M. PMID: 31831434.
View in: PubMed Mentions: 1 Fields: Translation: Animals
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A 25 micron-thin microscope for imaging upconverting nanoparticles with NIR-I and NIR-II illumination. Theranostics. 2019; 9(26):8239-8252.
Najafiaghdam H, Papageorgiou E, Torquato NA, Tian B, Cohen BE, Anwar M. PMID: 31754393.
View in: PubMed Mentions: Fields: Translation: Animals
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Socioeconomic disparities in timeliness of care and outcomes for anal cancer patients. Cancer Med. 2019 12; 8(17):7186-7196.
Ahmad TR, Susko M, Lindquist K, Anwar M. PMID: 31595720.
View in: PubMed Mentions: Fields: Translation: Humans
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A multi-disciplinary model of survivorship care following definitive chemoradiation for anal cancer. BMC Cancer. 2019 Sep 11; 19(1):906.
Savoie MB, Laffan A, Brickman C, Daniels B, Levin A, Rowen T, Smith J, Van Blarigan EL, Hope TA, Berry-Lawhorn JM, Anwar M, Van Loon K. PMID: 31510960.
View in: PubMed Mentions: Fields: Translation: HumansPHPublic Health
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Low irradiance multiphoton imaging with alloyed lanthanide nanocrystals. Nat Commun. 2018 08 06; 9(1):3082.
Tian B, Fernandez-Bravo A, Najafiaghdam H, Torquato NA, Altoe MVP, Teitelboim A, Tajon CA, Tian Y, Borys NJ, Barnard ES, Anwar M, Chan EM, Schuck PJ, Cohen BE. PMID: 30082844.
View in: PubMed Mentions: 6 Fields:
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A high-throughput flow cytometry-on-a-CMOS platform for single-cell dielectric spectroscopy at microwave frequencies. Lab Chip. 2018 07 10; 18(14):2065-2076.
Chien JC, Ameri A, Yeh EC, Killilea AN, Anwar M, Niknejad AM. PMID: 29872834.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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Real-time cancer detection with an integrated lensless fluorescence contact imager. Biomed Opt Express. 2018 Aug 01; 9(8):3607-3623.
Papageorgiou EP, Zhang H, Giverts S, Park C, Boser BE, Anwar M. PMID: 30338143.
View in: PubMed Mentions:
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Imaging of IR700DX Labeled Mouse Breast Tumor Using a Custom Angle-Selective Fluorescence Contact Imaging System. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:1-4.
Papageorgiou EP, Giverts S, Zhang H, Park C, Boser BE, Anwar M. PMID: 30440261.
View in: PubMed Mentions:
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A Molecular Imaging "Skin A Time-resolving Intraoperative Imager for Microscopic Residual Cancer Detection Using Enhanced Upconverting Nanoparticles. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:1-4.
Najafiaghdam H, Papageorgiou P, Torquato NA, Tajon CA, Zhang H, Park C, Boser B, Cohen BE, Anwar M. PMID: 30440277.
View in: PubMed Mentions:
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Brain metastasis growth on preradiosurgical magnetic resonance imaging. Pract Radiat Oncol. 2018 Nov - Dec; 8(6):e369-e376.
Garcia MA, Anwar M, Yu Y, Duriseti S, Merritt B, Nakamura J, Hess C, Theodosopoulos PV, McDermott M, Sneed PK, Braunstein SE. PMID: 30174247.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Influence of respiratory motion management technique on radiation pneumonitis risk with robotic stereotactic body radiation therapy. J Appl Clin Med Phys. 2018 Jul; 19(4):48-57.
Chapman CH, McGuinness C, Gottschalk AR, Yom SS, Garsa AA, Anwar M, Braunstein SE, Sudhyadhom A, Keall P, Descovich M. PMID: 29700954.
View in: PubMed Mentions: Fields: Translation: Humans
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Angle-insensitive amorphous silicon optical filter for fluorescence contact imaging. Opt Lett. 2018 Feb 01; 43(3):354-357.
Papageorgiou EP, Zhang H, Boser BE, Park C, Anwar M. PMID: 29400857.
View in: PubMed Mentions: Fields:
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Relationship between radiation dose and microbleed formation in patients with malignant glioma. Radiat Oncol. 2017 Aug 10; 12(1):126.
Wahl M, Anwar M, Hess CP, Chang SM, Lupo JM. PMID: 28797254.
View in: PubMed Mentions: 2 Fields: Translation: HumansPHPublic Health
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Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017 09; 188(3):303-313.
Anwar M, Molinaro AM, Morin O, Chang SM, Haas-Kogan DA, Nelson SJ, Lupo JM. PMID: 28723274.
View in: PubMed Mentions: 2 Fields: Translation: HumansPHPublic Health
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Respiration-Induced Intraorgan Deformation of the Liver: Implications for Treatment Planning in Patients Treated With Fiducial Tracking. Technol Cancer Res Treat. 2017 Dec; 16(6):776-782.
Paulsson AK, Yom SS, Anwar M, Pinnaduwage D, Sudhyadhom A, Gottschalk AR, Chang AJ, Descovich M. PMID: 28071340.
View in: PubMed Mentions: Fields:
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Delineation of radiation therapy target volumes for cutaneous malignancies involving the ophthalmic nerve (cranial nerve V-1) pathway. Pract Radiat Oncol. 2016 Nov - Dec; 6(6):e277-e281.
Anwar M, Yu Y, Glastonbury CM, El-Sayed IH, Yom SS. PMID: 27687189.
View in: PubMed Mentions: Fields: Translation: Humans
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Outcomes of hypofractionated stereotactic body radiotherapy boost for intermediate and high-risk prostate cancer. Radiat Oncol. 2016 Jan 21; 11:8.
Anwar M, Weinberg V, Seymour Z, Hsu IJ, Roach M, Gottschalk AR. PMID: 26792201.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Standardization and quality assurance of radiation therapy volumes for adults with high-grade gliomas. Semin Radiat Oncol. 2014 Oct; 24(4):259-64.
Fogh S, Wahl M, Anwar M, Haas-Kogan D, Clarke JL, Sneed PK. PMID: 25219810.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Hypofractionated SBRT versus conventionally fractionated EBRT for prostate cancer: comparison of PSA slope and nadir. Radiat Oncol. 2014 Feb 02; 9:42.
Anwar M, Weinberg V, Chang AJ, Hsu IC, Roach M, Gottschalk A. PMID: 24484652.
View in: PubMed Mentions: 14 Fields: Translation: Humans
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Role of endorectal MR imaging and MR spectroscopic imaging in defining treatable intraprostatic tumor foci in prostate cancer: quantitative analysis of imaging contour compared to whole-mount histopathology. Radiother Oncol. 2014 Feb; 110(2):303-8.
Anwar M, Westphalen AC, Jung AJ, Noworolski SM, Simko JP, Kurhanewicz J, Roach M, Carroll PR, Coakley FV. PMID: 24444524.
View in: PubMed Mentions: 11 Fields: Translation: Humans
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Role of stereotactic body radiotherapy in spinal metastasis and subsequent fracture risk: identifying and treating the at-risk patient. CNS Oncol. 2013 Sep; 2(5):437-45.
Anwar M, Barani IJ. PMID: 25054666.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Protein array patterning by diffusive gel stamping. PLoS One. 2012; 7(10):e46382.
Anwar M, Gupta PB, Palaniapan R, Matsudaira P. PMID: 23071560.
View in: PubMed Mentions: Fields: Translation: Cells
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Magnetic resonance imaging of massive ovarian edema in pregnancy. J Comput Assist Tomogr. 2010 Nov-Dec; 34(6):865-7.
Coakley FV, Anwar M, Poder L, Wang ZJ, Yeh BM, Joe BN. PMID: 21084901.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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Applied Physics Letters. A Wireless-Compatible CMOS-Based Optics-Free Microarray Imager. 2009; 94.
Anwar, M., Aytur, T., Matsudaira, P.
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A novel magnetic bead bioassay platform using a microchip-based sensor for infectious disease diagnosis. J Immunol Methods. 2006 Jul 31; 314(1-2):21-9.
Aytur T, Foley J, Anwar M, Boser B, Harris E, Beatty PR. PMID: 16842813.
View in: PubMed Mentions: 29 Fields: Translation: HumansAnimals
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Applied Physics Letters. Atomic force microscopy with time resolution of microseconds. 2005; 86(1):014101-014101-3.
M Anwar, I Rousso.
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Year | Publications |
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2005 | 1 | 2006 | 1 | 2009 | 1 | 2010 | 1 | 2012 | 1 | 2013 | 1 | 2014 | 3 | 2016 | 2 | 2017 | 3 | 2018 | 8 | 2019 | 4 | 2020 | 2 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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