Loading...

Melanie Ott, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1650 Owens St
San Francisco CA 94107
Phone415-734-4807
ORCID ORCID Icon0000-0002-5697-1274 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of Frankfurt/MainM.D1991
    Picower Graduate SchoolPh.D1997

    Collapse Overview 
    Collapse Overview
    My laboratory is interested in the molecular mechanisms of viral pathogenesis. We focus on two viruses: HIV-1 and Hepatitis C Virus (HCV). Both are important public health problems and share common traits including high propensities to establish chronic infections and a lack of efficient vaccines. Our HIV efforts focus on viral transcription and latency as remaining barriers to viral eradication. We focus specifically on posttranslational modifications of the HIV transactivator Tat as potential targets to manipulate viral transcription therapeutically. In the past, we defined Tat acetylation and deacetylation as important steps in the Tat transactivation cycle and recently identified acetylation of the RNA polymerase II as an important regulatory step in transcription elongation. We are also interested in Tat-host cell interactions, specifically how Tat expression in infected T cells dysregulates immune functions and supports a premature aging syndrome observed in HIV+ individuals. Our HCV research focuses on the interaction of viral proteins with intracellular lipid droplets. These organelles play a critical role in the assembly of HCV progeny virions and are occupied in infected cells by the HCV nucleocapsid core. We recently showed that core interacts with the triglyceride-synthesizing enzyme DGAT1, and that this interaction plays a central role in the recruitment of core to lipid droplets. We are currently defining the role of lipid droplets in related viruses such as Dengue and Zika Virus and performed a comprehensive protein:protein interaction analysis of HCV proteins and hepatoma cells, which identified many novel factors involved in the infection. Both, HCV and HIV research in my laboratory includes replication studies with infectious viral clones, which are performed in the BSL3 laboratory. Recent rotation projects in the lab:
    - defining the interaction of Dengue virus with lipid droplets
    - characterizing a new posttranslational modification of Tat at lysine 71
    - validating interaction partners of SIRT1 in T cells

    Collapse Research 
    Collapse Research Activities and Funding
    Modeling intestinal dysfunction in HIV infection with organoid technology
    NIH/NIDDK R01DK123746Jan 10, 2020 - Dec 31, 2024
    Role: Principal Investigator
    Single-Cell Transcriptomics of Non-Activated Latently Infected T cells Isolated from HIV+ Drug Users
    NIH/NIDA R61DA048444Mar 1, 2019 - Dec 31, 2021
    Role: Principal Investigator
    Harnessing the RNA-Binding Properties of Cas13a for HIV-1 Self-Testing
    NIH/NIAID R61AI140465Aug 1, 2018 - Jul 31, 2021
    Role: Principal Investigator
    Targeting lysine methylation for latency reversal in HIV-infected drug users
    NIH/NIDA R01DA043142Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    A new model of accelerated immune aging in HIV-infected drug users
    NIH/NIDA DP1DA038043Jun 1, 2014 - May 31, 2020
    Role: Principal Investigator
    Promoting Underrepresented Minority Advancement in the Sciences (PUMAS)
    NIH/NHLBI R25HL121037Apr 1, 2014 - Mar 31, 2024
    Role: Principal Investigator
    Role of Lipid Droplets in Hepatitis C Virus Infection
    NIH/NIAID R01AI097552Mar 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Mechanisms and Functions of Core-induced Lipid Droplet Accumulation in Hepatitis
    NIH/NIAID R56AI085056Sep 1, 2010 - Aug 31, 2012
    Role: Principal Investigator
    Role of Tat and SIRT1 in the T-cell Hyperactivation Syndrome Induced by HIV-1
    NIH/NIAID R01AI081651Jan 1, 2010 - Dec 31, 2014
    Role: Principal Investigator
    Role of Factor Acetylation in the Regulation of HIV Transcription
    NIH/NIAID R37AI083139Jul 15, 2009 - Jun 30, 2024
    Role: Principal Investigator
    Role of Factor Acetylation in the Regulation of HIV Transcription
    NIH/NIAID R01AI083139Apr 1, 2009 - Jun 30, 2018
    Role: Principal Investigator
    Role of mitochondrial core protein in Hepatitis C Virus pathogenesis
    NIH/NIAID R03AI069090Jul 1, 2007 - Jun 30, 2009
    Role: Principal Investigator
    Role of SIRT1 as a transcriptional coactivator of HIV-1
    NIH/NIAID R56AI067118Mar 16, 2007 - Feb 28, 2009
    Role: Principal Investigator
    Recruitment and activation of RSK2 by HIV Tat
    NIH/NIAID R21AI065248Mar 1, 2005 - Feb 28, 2007
    Role: Principal Investigator
    p90 ribosomal S6 kinase 2 (RSK2) and HIV transcription
    NIH/NIAID R03AI057179Jun 1, 2003 - May 31, 2005
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Turning up the heat on HIV-1. Proc Natl Acad Sci U S A. 2020 Jun 30. Chen IP, Ott M. PMID: 32606243.
      View in: PubMed   Mentions:    Fields:    
    2. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Jun 28. Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero D, Zhou Y, Dugourd A, Valdeolivas A, Patil T, Li Q, Hüttenhain R, Cakir M, Muralidharan M, Kim M, Jang G, Tutuncuoglu B, Hiatt J, Guo JZ, Xu J, Bouhaddou S, Mathy CJP, Gaulton A, Manners EJ, Félix E, Shi Y, Goff M, Lim JK, McBride T, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, De Wit E, Leach AR, Kortemme T, Shoichet B, Ott M, Saez-Rodriguez J, tenOever BR, Mullins RD, Fischer ER, Kochs G, Grosse R, García-Sastre A, Vignuzzi M, Johnson JR, Shokat KM, Swaney DL, Beltrao P, Krogan NJ. PMID: 32645325.
      View in: PubMed   Mentions: 1     Fields:    
    3. FOXO1 promotes HIV latency by suppressing ER stress in T cells. Nat Microbiol. 2020 Jun 15. Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA, Walter M, Habrylo I, Cruz A, Deeks S, Pillai S, Verdin E, Ott M. PMID: 32541947.
      View in: PubMed   Mentions: 1     Fields:    
    4. An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections. Semin Cell Dev Biol. 2020 Jun 15. Leon K, Ott M. PMID: 32553580.
      View in: PubMed   Mentions:    Fields:    
    5. A combinatorial view of old and new RNA polymerase II modifications. Transcription. 2020 Apr; 11(2):66-82. Lyons DE, McMahon S, Ott M. PMID: 32401151.
      View in: PubMed   Mentions:    Fields:    
    6. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Apr 30. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    7. Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract. Nat Commun. 2019 09 25; 10(1):4344. Khan S, Lew I, Wu F, Fritts L, Fontaine KA, Tomar S, Trapecar M, Shehata HM, Ott M, Miller CJ, Sanjabi S. PMID: 31554802.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins. Mol Cell. 2019 06 20; 74(6):1164-1174.e4. Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M. PMID: 31054975.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets. Methods Mol Biol. 2019; 1983:3-16. Schilling B, Meyer JG, Wei L, Ott M, Verdin E. PMID: 31087289.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. A BAF'ling Approach to Curing HIV. Cell Chem Biol. 2018 12 20; 25(12):1441-1442. Tomar S, Ali I, Ott M. PMID: 30576660.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. How cells hush a viral invader. Nature. 2018 12; 564(7735):193-194. Fozouni P, Ott M. PMID: 30531877.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    12. The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein. mBio. 2018 11 06; 9(6). Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M. PMID: 30401782.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    13. Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Chem Rev. 2018 02 14; 118(3):1216-1252. Ali I, Conrad RJ, Verdin E, Ott M. PMID: 29405707.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. J Exp Med. 2018 01 02; 215(1):51-62. Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M. PMID: 29191913.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S8-S22. Boehm D, Ott M. PMID: 29140109.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes. Mol Cell. 2017 Sep 21; 67(6):1001-1012.e6. Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M. PMID: 28844864.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    17. Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines. Bio Protoc. 2017 Jun 05; 7(11). Boehm D, Ott M. PMID: 29082287.
      View in: PubMed   Mentions:
    18. Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines. Bio Protoc. 2017 May 20; 7(10). Boehm D, Ott M. PMID: 28835903.
      View in: PubMed   Mentions:
    19. SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency. Cell Host Microbe. 2017 May 10; 21(5):569-579.e6. Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M. PMID: 28494238.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    20. Retrovirus Integration: Some Assembly Required? Cell Host Microbe. 2016 Dec 14; 20(6):702-704. Ali I, Conrad RJ, Ott M. PMID: 27978432.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. PMID: 27978436.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    22. Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication. J Exp Med. 2016 12 12; 213(13):2913-2929. Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S. PMID: 27852793.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    23. Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions. Virol J. 2016 Oct 20; 13(1):175. Ott M, Marques D, Funk C, Bailer SM. PMID: 27765046.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 08; 22(8):839-50. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. PMID: 27400264.
      View in: PubMed   Mentions: 120     Fields:    Translation:Humans
    25. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 2016 05 31; 5. Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. PMID: 27244239.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    26. The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7. J Biol Chem. 2016 07 29; 291(31):16240-8. Ali I, Ramage H, Boehm D, Dirk LM, Sakane N, Hanada K, Pagans S, Kaehlcke K, Aull K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M. PMID: 27235396.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection. Curr Opin Cell Biol. 2016 08; 41:117-24. Meyers NL, Fontaine KA, Kumar GR, Ott M. PMID: 27240021.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses. ACS Chem Biol. 2016 Mar 18; 11(3):669-80. Conrad RJ, Ott M. PMID: 26845514.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures. Mol Nutr Food Res. 2016 Mar; 60(3):661-71. Rosenkranz E, Metz CH, Maywald M, Hilgers RD, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, Plümäkers B, Rink L. PMID: 26614004.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    30. Subcellular trafficking and functional importance of herpes simplex virus type 1 glycoprotein M domains. J Gen Virol. 2015 Nov; 96(11):3313-3325. Striebinger H, Zhang J, Ott M, Funk C, Radtke K, Duron J, Ruzsics Z, Haas J, Lippé R, Bailer SM. PMID: 26265177.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    31. Manipulation of the host protein acetylation network by human immunodeficiency virus type 1. Crit Rev Biochem Mol Biol. 2015; 50(4):314-25. Jeng MY, Ali I, Ott M. PMID: 26329395.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    32. The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. PLoS Pathog. 2015 Jun; 11(6):e1004957. Funk C, Ott M, Raschbichler V, Nagel CH, Binz A, Sodeik B, Bauerfeind R, Bailer SM. PMID: 26083367.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    33. SIRT1 deacetylates ROR?t and enhances Th17 cell generation. J Exp Med. 2015 Jun 01; 212(6):973. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. PMID: 25987725.
      View in: PubMed   Mentions: 4     Fields:    
    34. SIRT1 deacetylates ROR?t and enhances Th17 cell generation. J Exp Med. 2015 May 04; 212(5):607-17. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. PMID: 25918343.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    35. Membrane Flotation Assay. Bio Protoc. 2015 Apr 05; 5(7). Vogt DA, Ott M. PMID: 27540564.
      View in: PubMed   Mentions:
    36. Evolution of lysine acetylation in the RNA polymerase II C-terminal domain. BMC Evol Biol. 2015 Mar 10; 15:35. Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA. PMID: 25887984.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. Mol Cell. 2015 Jan 22; 57(2):329-340. Ramage HR, Kumar GR, Verschueren E, Johnson JR, Von Dollen J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M. PMID: 25616068.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    38. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Nat Rev Mol Cell Biol. 2015 04; 16(4):258-64. Verdin E, Ott M. PMID: 25549891.
      View in: PubMed   Mentions: 132     Fields:    Translation:Cells
    39. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014 Dec 26; 289(52):35770-80. Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. PMID: 25381252.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    40. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. PMID: 24207025.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    41. Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. J Virol. 2013 Dec; 87(24):13354-69. Webster B, Ott M, Greene WC. PMID: 24089557.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    42. Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Mol Cell. 2013 Jul 25; 51(2):132-4. Verdin E, Ott M. PMID: 23870140.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    43. Bromodomain proteins in HIV infection. Viruses. 2013 Jun 21; 5(6):1571-86. Boehm D, Conrad RJ, Ott M. PMID: 23793227.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    44. Three rules for HIV latency: location, location, and location. Cell Host Microbe. 2013 Jun 12; 13(6):625-6. Ott M, Verdin E. PMID: 23768485.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    45. How the antiviral immune response boosts liver fat. Nat Med. 2013 Jun; 19(6):671-2. Camus G, Ott M. PMID: 23744144.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    46. Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. PLoS Pathog. 2013; 9(4):e1003302. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. PMID: 23593007.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    47. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013 Apr 05; 288(14):9915-23. Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. PMID: 23420847.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    48. Snapshots: chromatin control of viral infection. Virology. 2013 Jan 05; 435(1):141-56. Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM. PMID: 23217624.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    49. Lipid droplets and viral infections. Methods Cell Biol. 2013; 116:167-90. Camus G, Vogt DA, Kondratowicz AS, Ott M. PMID: 24099293.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    50. Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J Virol. 2013 Jan; 87(1):581-96. Webster B, Wissing S, Herker E, Ott M, Greene WC. PMID: 23097449.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol. 2012 Mar 15; 188(6):2712-21. Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. PMID: 22312127.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    52. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle. 2013 Feb 01; 12(3):452-62. Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. PMID: 23255218.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    53. The control of HIV transcription: keeping RNA polymerase II on track. Cell Host Microbe. 2011 Nov 17; 10(5):426-35. Ott M, Geyer M, Zhou Q. PMID: 22100159.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    54. Emerging role of lipid droplets in host/pathogen interactions. J Biol Chem. 2012 Jan 20; 287(4):2280-7. Herker E, Ott M. PMID: 22090026.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    55. Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem. 2012 Jan 06; 287(2):1090-9. Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. PMID: 22084242.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    56. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem. 2011 Dec 09; 286(49):42615-25. Harris C, Herker E, Farese RV, Ott M. PMID: 21984835.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    57. Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog. 2011 Aug; 7(8):e1002184. Sakane N, Kwon HS, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M. PMID: 21876670.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    58. Functional characterization of the essential tail anchor of the herpes simplex virus type 1 nuclear egress protein pUL34. J Gen Virol. 2011 Dec; 92(Pt 12):2734-2745. Ott M, Tascher G, Haßdenteufel S, Zimmermann R, Haas J, Bailer SM. PMID: 21832006.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    59. Unique ties between hepatitis C virus replication and intracellular lipids. Trends Endocrinol Metab. 2011 Jun; 22(6):241-8. Herker E, Ott M. PMID: 21497514.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    60. HIV never ceases to surprise: Innovative methods in the quest for a cure. Methods. 2011 Jan; 53(1):1-2. Ott M. PMID: 21251605.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    61. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med. 2010 Nov; 16(11):1295-8. Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. PMID: 20935628.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    62. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23; 67(6):953-66. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. PMID: 20869593.
      View in: PubMed   Mentions: 238     Fields:    Translation:HumansAnimalsCells
    63. Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies. Methods. 2011 Jan; 53(1):91-6. Pagans S, Sakane N, Schnölzer M, Ott M. PMID: 20615470.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    64. CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation. Cell Cycle. 2010 May; 9(9):1697-705. Cho S, Schroeder S, Ott M. PMID: 20436276.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    65. HAT trick: p300, small molecule, inhibitor. Chem Biol. 2010 May 28; 17(5):417-8. Ott M, Verdin E. PMID: 20534339.
      View in: PubMed   Mentions: 4     Fields:    
    66. The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe. 2010 Mar 18; 7(3):234-44. Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M. PMID: 20227666.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    67. Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells. EMBO J. 2009 May 20; 28(10):1407-17. Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M. PMID: 19387490.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    68. Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J Pharmacol Exp Ther. 2009 Apr; 329(1):141-9. Ott M, Fricker G, Bauer B. PMID: 19147857.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    69. Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. J Neurosci. 2008 Nov 19; 28(47):12305-17. Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH. PMID: 19020024.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    70. The ups and downs of SIRT1. Trends Biochem Sci. 2008 Nov; 33(11):517-25. Kwon HS, Ott M. PMID: 18805010.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    71. Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe. 2008 Mar 13; 3(3):158-67. Kwon HS, Brent MM, Getachew R, Jayakumar P, Chen LF, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M. PMID: 18329615.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    72. Recruitment and activation of RSK2 by HIV-1 Tat. PLoS One. 2007 Jan 17; 2(1):e151. Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M. PMID: 17225856.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    73. Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPH. Gastroenterology. 2006 Dec; 131(6):1879-86. Nieters A, Kallinowski B, Brennan P, Ott M, Maynadié M, Benavente Y, Foretova L, Cocco PL, Staines A, Vornanen M, Whitby D, Boffetta P, Becker N, De Sanjosé S. PMID: 17087949.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    74. The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem. 2006 Jul 21; 281(29):19960-8. Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E. PMID: 16687403.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    75. Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry. Methods. 2005 Aug; 36(4):376-82. Dormeyer W, Ott M, Schnölzer M. PMID: 16085422.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    76. Decoding Tat: the biology of HIV Tat posttranslational modifications. Microbes Infect. 2005 Oct; 7(13):1364-9. Hetzer C, Dormeyer W, Schnölzer M, Ott M. PMID: 16046164.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    77. Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays. Mol Cell Proteomics. 2005 Sep; 4(9):1226-39. Dormeyer W, Ott M, Schnölzer M. PMID: 15933374.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    78. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol. 2005 Feb; 3(2):e41. Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M. PMID: 15719057.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    79. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol. 2004 Aug; 78(15):7958-68. Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M. PMID: 15254168.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    80. HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Mol Cell. 2004 Jan 30; 13(2):179-90. Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D'Aloja P, Sixt M, Kolanus J, Ott M, Kolanus W, Schuler G, Baur AS. PMID: 14759364.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    81. Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp. 2004; 259:182-93; discussion 193-6, 223-5. Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou MM, Verdin E. PMID: 15171254.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    82. Acetylation of the HIV-1 Tat protein: an in vitro study. Anal Bioanal Chem. 2003 Aug; 376(7):994-1005. Dormeyer W, Dorr A, Ott M, Schnölzer M. PMID: 12904943.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    83. Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell. 2003 Jul; 12(1):167-76. Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. PMID: 12887902.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    84. Release and intercellular transfer of cell surface CD81 via microparticles. J Immunol. 2002 Nov 15; 169(10):5531-7. Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M. PMID: 12421929.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    85. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002 Aug 19; 158(4):647-57. Schwer B, North BJ, Frye RA, Ott M, Verdin E. PMID: 12186850.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansCells
    86. Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J. 2002 Jun 03; 21(11):2715-23. Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M. PMID: 12032084.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    87. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell. 2002 Mar; 9(3):575-86. Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM. PMID: 11931765.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    Melanie's Networks
    Concepts (400)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (83)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _
    ↑