Melanie Ott, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1650 Owens St
San Francisco CA 94107
Phone415-734-4807
ORCID ORCID Icon0000-0002-5697-1274 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Frankfurt/MainM.D1991
    Picower Graduate SchoolPh.D1997
    University of California, San Francisco, CA2021Diversity, Equity & Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    My laboratory is interested in the molecular mechanisms of viral pathogenesis. We focus on a variety of viruses including HIV-1, Hepatitis B and C Virus (HBV and HCV), Zika and SARS-CoV-2. We believe that identifying common host pathways involved in different viruses can lead to the discovery of panviral therapeutics. All are important public health problems and with HCV and HIV sharing common traits including high propensities to establish chronic infections and a lack of efficient vaccines, and Zika and SARS-CoV-2 causing global pandemics leading to death and disability. In recent years, we have established four main technologies to study these viruses—rapid quantitative tests, human organoids, a viral protein library and transcriptomics and chromatin biology. We recently applied these technologies to the studies of SARS-CoV-2, leading to the development of a new direct detection CRISPR diagnostic and the identification of shared host factors necessary for the replication of SARS-CoV-2 and common cold coronaviruses. SARS-CoV-2, HCV and HIV research in my laboratory includes replication studies with infectious viral clones, which are performed in the BSL3 laboratory. Recent rotation projects in the lab:

    • characterizing influenza B infection in human airway organoids
    • developing a new hepatitis B clone to screen for host factors regulating cccDNA formation
    Collapse Websites
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    Collapse Research 
    Collapse Research Activities and Funding
    HOPE - HIV Obstruction by Programmed Epigenetics
    NIH UM1AI164559Aug 16, 2021 - Apr 30, 2026
    Role: Principal Investigator
    Modeling intestinal dysfunction in HIV infection with organoid technology
    NIH R01DK123746Jan 10, 2020 - Dec 31, 2024
    Role: Principal Investigator
    Harnessing the RNA-Binding Properties of Cas13a for HIV-1 Self-Testing
    NIH R33AI140465Aug 1, 2019 - Jul 31, 2023
    Role: Principal Investigator
    Single-Cell Transcriptomics of Non-Activated Latently Infected T cells Isolated from HIV+ Drug Users
    NIH R61DA048444Mar 1, 2019 - Dec 31, 2021
    Role: Principal Investigator
    Harnessing the RNA-Binding Properties of Cas13a for HIV-1 Self-Testing
    NIH R61AI140465Aug 1, 2018 - Jul 31, 2021
    Role: Principal Investigator
    Targeting lysine methylation for latency reversal in HIV-infected drug users
    NIH R01DA043142Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    A new model of accelerated immune aging in HIV-infected drug users
    NIH DP1DA038043Jun 1, 2014 - May 31, 2021
    Role: Principal Investigator
    Promoting Underrepresented Minority Advancement in the Sciences (PUMAS)
    NIH R25HL121037Apr 1, 2014 - Mar 31, 2024
    Role: Principal Investigator
    Role of Lipid Droplets in Hepatitis C Virus Infection
    NIH R01AI097552Mar 1, 2014 - Apr 30, 2020
    Role: Principal Investigator
    Mechanisms and Functions of Core-induced Lipid Droplet Accumulation in Hepatitis
    NIH R56AI085056Sep 1, 2010 - Aug 31, 2012
    Role: Principal Investigator
    Role of Tat and SIRT1 in the T-cell Hyperactivation Syndrome Induced by HIV-1
    NIH R01AI081651Jan 1, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Role of Factor Acetylation in the Regulation of HIV Transcription
    NIH R37AI083139Jul 15, 2009 - Jun 30, 2024
    Role: Principal Investigator
    Role of Factor Acetylation in the Regulation of HIV Transcription
    NIH R01AI083139Apr 1, 2009 - Jun 30, 2019
    Role: Principal Investigator
    Role of mitochondrial core protein in Hepatitis C Virus pathogenesis
    NIH R03AI069090Jul 1, 2007 - Jun 30, 2009
    Role: Principal Investigator
    Role of SIRT1 as a transcriptional coactivator of HIV-1
    NIH R56AI067118Mar 16, 2007 - Feb 28, 2009
    Role: Principal Investigator
    Recruitment and activation of RSK2 by HIV Tat
    NIH R21AI065248Mar 1, 2005 - Feb 28, 2007
    Role: Principal Investigator
    p90 ribosomal S6 kinase 2 (RSK2) and HIV transcription
    NIH R03AI057179Jun 1, 2003 - May 31, 2005
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants. Cell. 2022 Apr 28; 185(9):1539-1548.e5. Servellita V, Syed AM, Morris MK, Brazer N, Saldhi P, Garcia-Knight M, Sreekumar B, Khalid MM, Ciling A, Chen PY, Kumar GR, Gliwa AS, Nguyen J, Sotomayor-Gonzalez A, Zhang Y, Frias E, Prostko J, Hackett J, Andino R, Wadford DA, Hanson C, Doudna J, Ott M, Chiu CY. PMID: 35429436; PMCID: PMC8930394.
      View in: PubMed   Mentions:
    2. Accelerating PERx Reaction Enables Covalent Nanobodies for Potent Neutralization of SARS-Cov-2 and Variants. bioRxiv. 2022 Mar 14. Yu B, Li S, Tabata T, Wang N, Kumar GR, Liu J, Ott MM, Wang L. PMID: 35313590; PMCID: PMC8936105.
      View in: PubMed   Mentions:
    3. Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system. Open Biol. 2022 03; 12(3):210320. Natarajan V, Simoneau CR, Erickson AL, Meyers NL, Baron JL, Cooper S, McDevitt TC, Ott M. PMID: 35232252; PMCID: PMC8889170.
      View in: PubMed   Mentions:
    4. Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination. medRxiv. 2022 Feb 09. Suryawanshi RK, Chen IP, Ma T, Syed AM, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, George AF, Kumar GR, Montano M, Garcia-Knight MA, Brazer N, Saldhi P, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna J, Ott M, Fang X, Maishan M. PMID: 35075459; PMCID: PMC8786226.
      View in: PubMed   Mentions:
    5. SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. bioRxiv. 2022 Jan 05. Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Gross JD, Krogan NJ, Schilling B, Ott M, Verdin E. PMID: 35018374; PMCID: PMC8750649.
      View in: PubMed   Mentions:
    6. Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles. medRxiv. 2022 Jan 02. Syed AM, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Taha TY, Tabata T, Chen IP, Ott M, Doudna JA. PMID: 34981067; PMCID: PMC8722610.
      View in: PubMed   Mentions:
    7. Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2. bioRxiv. 2021 Nov 15. Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Carlson-Stevermer J, Gupta M, Zhang MY, Soveg FW, Hayashi JM, Taha TY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, QCRG Structural Biology Consortium, Krogan N, Galonic Fujimori D, Ott M. PMID: 34816261; PMCID: PMC8609896.
      View in: PubMed   Mentions:
    8. Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance. Cell. 2021 12 09; 184(25):6022-6036.e18. Chaturvedi S, Vasen G, Pablo M, Chen X, Beutler N, Kumar A, Tanner E, Illouz S, Rahgoshay D, Burnett J, Holguin L, Chen PY, Ndjamen B, Ott M, Rodick R, Rogers T, Smith DM, Weinberger LS. PMID: 34838159; PMCID: PMC8577993.
      View in: PubMed   Mentions:
    9. Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles. Science. 2021 Dec 24; 374(6575):1626-1632. Syed AM, Taha TY, Tabata T, Chen IP, Ciling A, Khalid MM, Sreekumar B, Chen PY, Hayashi JM, Soczek KM, Ott M, Doudna JA. PMID: 34735219; PMCID: PMC9005165.
      View in: PubMed   Mentions:
    10. Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases. Nat Chem Biol. 2021 Nov; 17(11):1210. Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim S, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. PMID: 34616098; PMCID: PMC8493939.
      View in: PubMed   Mentions:    Fields:    
    11. Accelerated RNA detection using tandem CRISPR nucleases. Nat Chem Biol. 2021 09; 17(9):982-988. Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim S, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. PMID: 34354262.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2. ACS Infect Dis. 2021 08 13; 7(8):2337-2351. Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. PMID: 34129317; PMCID: PMC8231672.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    13. Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19. Sci Rep. 2021 06 10; 11(1):12310. Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre A, Ott M, Sirota M. PMID: 34112877; PMCID: PMC8192542.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator. bioRxiv. 2021 Jun 02. Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP. PMID: 34100012; PMCID: PMC8183007.
      View in: PubMed   Mentions:
    15. Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein. bioRxiv. 2021 Apr 20. Weinberg ZY, Hilburger CE, Kim M, Cao L, Khalid M, Elmes S, Diwanji D, Hernandez E, Lopez J, Schaefer K, Smith AM, Zhou F, QCRG Structural Biology Consortium, Renuka Kumar G, Ott M, Baker D, El-Samad H. PMID: 33907743; PMCID: PMC8077567.
      View in: PubMed   Mentions:
    16. Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant. Cell. 2021 06 24; 184(13):3426-3437.e8. Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Sanchez San Martin C, Federman S, Cheng J, Balcerek J, Taylor J, Streithorst JA, Miller S, Sreekumar B, Chen PY, Schulze-Gahmen U, Taha TY, Hayashi JM, Simoneau CR, Kumar GR, McMahon S, Lidsky PV, Xiao Y, Hemarajata P, Green NM, Espinosa A, Kath C, Haw M, Bell J, Hacker JK, Hanson C, Wadford DA, Anaya C, Ferguson D, Frankino PA, Shivram H, Lareau LF, Wyman SK, Ott M, Andino R, Chiu CY. PMID: 33991487; PMCID: PMC8057738.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    17. Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts. Methods. 2021 Apr 18. Telwatte S, Martin HA, Marczak R, Fozouni P, Vallejo-Gracia A, Kumar GR, Murray V, Lee S, Ott M, Wong JK, Yukl SA. PMID: 33882362; PMCID: PMC8105137.
      View in: PubMed   Mentions:    Fields:    
    18. Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19. Res Sq. 2021 Mar 30. Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre A, Ott M, Sirota M. PMID: 33821262; PMCID: PMC8020993.
      View in: PubMed   Mentions:
    19. Accelerated RNA detection using tandem CRISPR nucleases. medRxiv. 2021 Mar 24. Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, de León Derby MD, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim SE, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. PMID: 33791736; PMCID: PMC8010768.
      View in: PubMed   Mentions:
    20. A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection. Cell Rep. 2021 03 16; 34(11):108859. Kulsuptrakul J, Wang R, Meyers NL, Ott M, Puschnik AS. PMID: 33730579; PMCID: PMC8893346.
      View in: PubMed   Mentions: 3     Fields:    
    21. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 04 21; 13(590). Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC. PMID: 33723017; PMCID: PMC8128284.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    22. Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation. medRxiv. 2021 Mar 09. Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Sanchez San Martin C, Federman S, Cheng J, Balcerek J, Taylor J, Streithorst JA, Miller S, Kumar GR, Sreekumar B, Chen PY, Schulze-Gahmen U, Taha TY, Hayashi J, Simoneau CR, McMahon S, Lidsky PV, Xiao Y, Hemarajata P, Green NM, Espinosa A, Kath C, Haw M, Bell J, Hacker JK, Hanson C, Wadford DA, Anaya C, Ferguson D, Lareau LF, Frankino PA, Shivram H, Wyman SK, Ott M, Andino R, Chiu CY. PMID: 33758899; PMCID: PMC7987058.
      View in: PubMed   Mentions:
    23. Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA. J Virol Methods. 2021 06; 292:114115. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. PMID: 33667568; PMCID: PMC7923865.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo. J Virol. 2021 Feb 03. Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. PMID: 33536176; PMCID: PMC8103695.
      View in: PubMed   Mentions: 1     Fields:    
    25. Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. bioRxiv. 2021 Jan 18. Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Perez Y, Mostajo-Radji MA, Wang S, Velmeshev D, Salma J, Kumar GR, Pollen AA, Crouch EE, Ott M, Kriegstein AR. PMID: 33469577; PMCID: PMC7814814.
      View in: PubMed   Mentions:
    26. Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2. bioRxiv. 2021 Jan 12. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. PMID: 33469579; PMCID: PMC7814816.
      View in: PubMed   Mentions:
    27. Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2021 Jan; 3(1):120-121. Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. PMID: 33303985.
      View in: PubMed   Mentions: 2  
    28. Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses. Cell. 2021 01 07; 184(1):106-119.e14. Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS. PMID: 33333024; PMCID: PMC7723770.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    29. Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy. Cell. 2021 01 21; 184(2):323-333.e9. Fozouni P, Son S, Díaz de León Derby M, Knott GJ, Gray CN, D'Ambrosio MV, Zhao C, Switz NA, Kumar GR, Stephens SI, Boehm D, Tsou CL, Shu J, Bhuiya A, Armstrong M, Harris AR, Chen PY, Osterloh JM, Meyer-Franke A, Joehnk B, Walcott K, Sil A, Langelier C, Pollard KS, Crawford ED, Puschnik AS, Phelps M, Kistler A, DeRisi JL, Doudna JA, Fletcher DA, Ott M. PMID: 33306959; PMCID: PMC7834310.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    30. Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology. Cell Stem Cell. 2020 12 03; 27(6):859-868. Simoneau CR, Ott M. PMID: 33275899; PMCID: PMC7713543.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell. 2020 12 03; 27(6):876-889.e12. Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F. PMID: 33232663; PMCID: PMC7670929.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    32. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2020 11; 2(11):1265-1283. Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. PMID: 33199924; PMCID: PMC7908681.
      View in: PubMed   Mentions: 25  Translation:HumansAnimalsCells
    33. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 12 18; 370(6523):1473-1479. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 33154106; PMCID: PMC7857409.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    34. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, et al. PMID: 33060197; PMCID: PMC7808408.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    35. SIRT1 is downregulated by autophagy in senescence and ageing. Nat Cell Biol. 2020 10; 22(10):1170-1179. Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL. PMID: 32989246; PMCID: PMC7805578.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    36. Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses. bioRxiv. 2020 Sep 24. Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi JM, Carlson-Stevermer J, Oki J, Holden K, Krogan NJ, Ott M, Puschnik AS. PMID: 32995787; PMCID: PMC7523113.
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    37. SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients. bioRxiv. 2020 Sep 12. Pérez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC. PMID: 32935097; PMCID: PMC7491510.
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    38. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. Cell Stem Cell. 2020 11 05; 27(5):840-851.e6. Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC. PMID: 32818433; PMCID: PMC7655723.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    39. An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation. bioRxiv. 2020 Aug 17. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 32817938; PMCID: PMC7430568.
      View in: PubMed   Mentions: 2  
    40. Turning up the heat on HIV-1. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16109-16111. Chen IP, Ott M. PMID: 32606243; PMCID: PMC7368259.
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    41. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 08 06; 182(3):685-712.e19. Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero D, Zhou Y, Dugourd A, Valdeolivas A, Patil T, Li Q, Hüttenhain R, Cakir M, Muralidharan M, Kim M, Jang G, Tutuncuoglu B, Hiatt J, Guo JZ, Xu J, Bouhaddou S, Mathy CJP, Gaulton A, Manners EJ, Félix E, Shi Y, Goff M, Lim JK, McBride T, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, De Wit E, Leach AR, Kortemme T, Shoichet B, Ott M, Saez-Rodriguez J, tenOever BR, Mullins RD, Fischer ER, Kochs G, Grosse R, García-Sastre A, Vignuzzi M, Johnson JR, Shokat KM, Swaney DL, Beltrao P, Krogan NJ. PMID: 32645325; PMCID: PMC7321036.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    42. FOXO1 promotes HIV latency by suppressing ER stress in T cells. Nat Microbiol. 2020 09; 5(9):1144-1157. Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA, Walter M, Habrylo I, Cruz A, Deeks S, Pillai S, Verdin E, Ott M. PMID: 32541947; PMCID: PMC7483895.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    43. An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections. Semin Cell Dev Biol. 2021 03; 111:101-107. Leon K, Ott M. PMID: 32553580; PMCID: PMC7295464.
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    44. A combinatorial view of old and new RNA polymerase II modifications. Transcription. 2020 04; 11(2):66-82. Lyons DE, McMahon S, Ott M. PMID: 32401151; PMCID: PMC7549748.
      View in: PubMed   Mentions: 2     Fields:    
    45. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
      View in: PubMed   Mentions: 1032     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    46. Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract. Nat Commun. 2019 09 25; 10(1):4344. Khan S, Lew I, Wu F, Fritts L, Fontaine KA, Tomar S, Trapecar M, Shehata HM, Ott M, Miller CJ, Sanjabi S. PMID: 31554802; PMCID: PMC6761111.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    47. Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins. Mol Cell. 2019 06 20; 74(6):1164-1174.e4. Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M. PMID: 31054975; PMCID: PMC6588463.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    48. High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets. Methods Mol Biol. 2019; 1983:3-16. Schilling B, Meyer JG, Wei L, Ott M, Verdin E. PMID: 31087289; PMCID: PMC6825508.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    49. A BAF'ling Approach to Curing HIV. Cell Chem Biol. 2018 12 20; 25(12):1441-1442. Tomar S, Ali I, Ott M. PMID: 30576660; PMCID: PMC6582950.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    50. How cells hush a viral invader. Nature. 2018 12; 564(7735):193-194. Fozouni P, Ott M. PMID: 30531877.
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    51. The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein. mBio. 2018 11 06; 9(6). Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M. PMID: 30401782; PMCID: PMC6222128.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    52. Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Chem Rev. 2018 02 14; 118(3):1216-1252. Ali I, Conrad RJ, Verdin E, Ott M. PMID: 29405707; PMCID: PMC6609103.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    53. Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. J Exp Med. 2018 01 02; 215(1):51-62. Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M. PMID: 29191913; PMCID: PMC5748845.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    54. Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S8-S22. Boehm D, Ott M. PMID: 29140109; PMCID: PMC5684665.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    55. The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes. Mol Cell. 2017 Sep 21; 67(6):1001-1012.e6. Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M. PMID: 28844864; PMCID: PMC5610089.
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    56. Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines. Bio Protoc. 2017 Jun 05; 7(11). Boehm D, Ott M. PMID: 29082287; PMCID: PMC5659638.
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    57. Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines. Bio Protoc. 2017 May 20; 7(10). Boehm D, Ott M. PMID: 28835903; PMCID: PMC5564680.
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    58. SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency. Cell Host Microbe. 2017 May 10; 21(5):569-579.e6. Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M. PMID: 28494238; PMCID: PMC5490666.
      View in: PubMed   Mentions: 28  Translation:HumansCells
    59. Retrovirus Integration: Some Assembly Required? Cell Host Microbe. 2016 Dec 14; 20(6):702-704. Ali I, Conrad RJ, Ott M. PMID: 27978432.
      View in: PubMed   Mentions: 1  Translation:HumansAnimalsCells
    60. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. PMID: 27978436; PMCID: PMC5354304.
      View in: PubMed   Mentions: 67  Translation:HumansCells
    61. Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication. J Exp Med. 2016 12 12; 213(13):2913-2929. Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S. PMID: 27852793; PMCID: PMC5154948.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    62. Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions. Virol J. 2016 Oct 20; 13(1):175. Ott M, Marques D, Funk C, Bailer SM. PMID: 27765046; PMCID: PMC5072318.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    63. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 08; 22(8):839-50. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. PMID: 27400264; PMCID: PMC5322797.
      View in: PubMed   Mentions: 194     Fields:    Translation:Humans
    64. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 2016 05 31; 5. Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. PMID: 27244239; PMCID: PMC4931907.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    65. The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7. J Biol Chem. 2016 07 29; 291(31):16240-8. Ali I, Ramage H, Boehm D, Dirk LM, Sakane N, Hanada K, Pagans S, Kaehlcke K, Aull K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M. PMID: 27235396; PMCID: PMC4965572.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    66. Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection. Curr Opin Cell Biol. 2016 08; 41:117-24. Meyers NL, Fontaine KA, Kumar GR, Ott M. PMID: 27240021; PMCID: PMC5477849.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    67. Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses. ACS Chem Biol. 2016 Mar 18; 11(3):669-80. Conrad RJ, Ott M. PMID: 26845514; PMCID: PMC5477850.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    68. Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures. Mol Nutr Food Res. 2016 Mar; 60(3):661-71. Rosenkranz E, Metz CH, Maywald M, Hilgers RD, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, Plümäkers B, Rink L. PMID: 26614004.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    69. Subcellular trafficking and functional importance of herpes simplex virus type 1 glycoprotein M domains. J Gen Virol. 2015 Nov; 96(11):3313-3325. Striebinger H, Zhang J, Ott M, Funk C, Radtke K, Duron J, Ruzsics Z, Haas J, Lippé R, Bailer SM. PMID: 26265177.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    70. Manipulation of the host protein acetylation network by human immunodeficiency virus type 1. Crit Rev Biochem Mol Biol. 2015; 50(4):314-25. Jeng MY, Ali I, Ott M. PMID: 26329395; PMCID: PMC4816045.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    71. The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. PLoS Pathog. 2015 Jun; 11(6):e1004957. Funk C, Ott M, Raschbichler V, Nagel CH, Binz A, Sodeik B, Bauerfeind R, Bailer SM. PMID: 26083367; PMCID: PMC4471197.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    72. SIRT1 deacetylates RORγt and enhances Th17 cell generation. J Exp Med. 2015 Jun 01; 212(6):973. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. PMID: 25987725; PMCID: PMC4451124.
      View in: PubMed   Mentions: 6     Fields:    
    73. SIRT1 deacetylates RORγt and enhances Th17 cell generation. J Exp Med. 2015 May 04; 212(5):607-17. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. PMID: 25918343; PMCID: PMC4419343.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    74. Membrane Flotation Assay. Bio Protoc. 2015 Apr 05; 5(7). Vogt DA, Ott M. PMID: 27540564; PMCID: PMC4987092.
      View in: PubMed   Mentions: 4  
    75. Evolution of lysine acetylation in the RNA polymerase II C-terminal domain. BMC Evol Biol. 2015 Mar 10; 15:35. Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA. PMID: 25887984; PMCID: PMC4362643.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    76. A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. Mol Cell. 2015 Jan 22; 57(2):329-340. Ramage HR, Kumar GR, Verschueren E, Johnson JR, Von Dollen J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M. PMID: 25616068; PMCID: PMC4305532.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    77. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Nat Rev Mol Cell Biol. 2015 04; 16(4):258-64. Verdin E, Ott M. PMID: 25549891.
      View in: PubMed   Mentions: 220     Fields:    Translation:Cells
    78. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014 Dec 26; 289(52):35770-80. Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. PMID: 25381252; PMCID: PMC4276846.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    79. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. PMID: 24207025; PMCID: PMC3936344.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    80. Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. J Virol. 2013 Dec; 87(24):13354-69. Webster B, Ott M, Greene WC. PMID: 24089557; PMCID: PMC3838274.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    81. Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Mol Cell. 2013 Jul 25; 51(2):132-4. Verdin E, Ott M. PMID: 23870140.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    82. Bromodomain proteins in HIV infection. Viruses. 2013 Jun 21; 5(6):1571-86. Boehm D, Conrad RJ, Ott M. PMID: 23793227; PMCID: PMC3717722.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    83. Three rules for HIV latency: location, location, and location. Cell Host Microbe. 2013 Jun 12; 13(6):625-6. Ott M, Verdin E. PMID: 23768485; PMCID: PMC3998752.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    84. How the antiviral immune response boosts liver fat. Nat Med. 2013 Jun; 19(6):671-2. Camus G, Ott M. PMID: 23744144.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    85. Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. PLoS Pathog. 2013; 9(4):e1003302. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. PMID: 23593007; PMCID: PMC3623766.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    86. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013 Apr 05; 288(14):9915-9923. Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. PMID: 23420847; PMCID: PMC3617291.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    87. Snapshots: chromatin control of viral infection. Virology. 2013 Jan 05; 435(1):141-56. Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM. PMID: 23217624; PMCID: PMC3531885.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    88. Lipid droplets and viral infections. Methods Cell Biol. 2013; 116:167-90. Camus G, Vogt DA, Kondratowicz AS, Ott M. PMID: 24099293.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    89. Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J Virol. 2013 Jan; 87(1):581-96. Webster B, Wissing S, Herker E, Ott M, Greene WC. PMID: 23097449; PMCID: PMC3536371.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    90. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol. 2012 Mar 15; 188(6):2712-21. Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. PMID: 22312127; PMCID: PMC3478122.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    91. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle. 2013 Feb 01; 12(3):452-62. Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. PMID: 23255218; PMCID: PMC3587446.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    92. The control of HIV transcription: keeping RNA polymerase II on track. Cell Host Microbe. 2011 Nov 17; 10(5):426-35. Ott M, Geyer M, Zhou Q. PMID: 22100159; PMCID: PMC3478145.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    93. Emerging role of lipid droplets in host/pathogen interactions. J Biol Chem. 2012 Jan 20; 287(4):2280-7. Herker E, Ott M. PMID: 22090026; PMCID: PMC3268388.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    94. Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem. 2012 Jan 06; 287(2):1090-9. Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. PMID: 22084242; PMCID: PMC3256921.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    95. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem. 2011 Dec 09; 286(49):42615-42625. Harris C, Herker E, Farese RV, Ott M. PMID: 21984835; PMCID: PMC3234948.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    96. Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog. 2011 Aug; 7(8):e1002184. Sakane N, Kwon HS, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M. PMID: 21876670; PMCID: PMC3158049.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    97. Functional characterization of the essential tail anchor of the herpes simplex virus type 1 nuclear egress protein pUL34. J Gen Virol. 2011 Dec; 92(Pt 12):2734-2745. Ott M, Tascher G, Haßdenteufel S, Zimmermann R, Haas J, Bailer SM. PMID: 21832006.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    98. Unique ties between hepatitis C virus replication and intracellular lipids. Trends Endocrinol Metab. 2011 Jun; 22(6):241-8. Herker E, Ott M. PMID: 21497514; PMCID: PMC3118981.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    99. HIV never ceases to surprise: Innovative methods in the quest for a cure. Methods. 2011 Jan; 53(1):1-2. Ott M. PMID: 21251605.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    100. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med. 2010 Nov; 16(11):1295-8. Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. PMID: 20935628; PMCID: PMC3431199.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansCells
    101. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23; 67(6):953-66. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. PMID: 20869593; PMCID: PMC3035103.
      View in: PubMed   Mentions: 335     Fields:    Translation:HumansAnimalsCells
    102. Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies. Methods. 2011 Jan; 53(1):91-6. Pagans S, Sakane N, Schnölzer M, Ott M. PMID: 20615470; PMCID: PMC3478124.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    103. CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation. Cell Cycle. 2010 May; 9(9):1697-705. Cho S, Schroeder S, Ott M. PMID: 20436276; PMCID: PMC2956491.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    104. HAT trick: p300, small molecule, inhibitor. Chem Biol. 2010 May 28; 17(5):417-8. Ott M, Verdin E. PMID: 20534339.
      View in: PubMed   Mentions: 4     Fields:    
    105. The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe. 2010 Mar 18; 7(3):234-44. Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M. PMID: 20227666; PMCID: PMC2844784.
      View in: PubMed   Mentions: 46  Translation:HumansCells
    106. Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells. EMBO J. 2009 May 20; 28(10):1407-17. Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M. PMID: 19387490; PMCID: PMC2688543.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    107. Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J Pharmacol Exp Ther. 2009 Apr; 329(1):141-9. Ott M, Fricker G, Bauer B. PMID: 19147857.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    108. Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. J Neurosci. 2008 Nov 19; 28(47):12305-17. Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH. PMID: 19020024; PMCID: PMC6671709.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    109. The ups and downs of SIRT1. Trends Biochem Sci. 2008 Nov; 33(11):517-25. Kwon HS, Ott M. PMID: 18805010.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    110. Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe. 2008 Mar 13; 3(3):158-67. Kwon HS, Brent MM, Getachew R, Jayakumar P, Chen LF, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M. PMID: 18329615; PMCID: PMC2680745.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    111. Recruitment and activation of RSK2 by HIV-1 Tat. PLoS One. 2007 Jan 17; 2(1):e151. Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M. PMID: 17225856; PMCID: PMC1764712.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    112. Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPH. Gastroenterology. 2006 Dec; 131(6):1879-86. Nieters A, Kallinowski B, Brennan P, Ott M, Maynadié M, Benavente Y, Foretova L, Cocco PL, Staines A, Vornanen M, Whitby D, Boffetta P, Becker N, De Sanjosé S. PMID: 17087949.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    113. The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem. 2006 Jul 21; 281(29):19960-8. Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E. PMID: 16687403.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    114. Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry. Methods. 2005 Aug; 36(4):376-82. Dormeyer W, Ott M, Schnölzer M. PMID: 16085422.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    115. Decoding Tat: the biology of HIV Tat posttranslational modifications. Microbes Infect. 2005 Oct; 7(13):1364-9. Hetzer C, Dormeyer W, Schnölzer M, Ott M. PMID: 16046164.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    116. Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays. Mol Cell Proteomics. 2005 Sep; 4(9):1226-39. Dormeyer W, Ott M, Schnölzer M. PMID: 15933374.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    117. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol. 2005 Feb; 3(2):e41. Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M. PMID: 15719057; PMCID: PMC546329.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    118. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol. 2004 Aug; 78(15):7958-68. Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M. PMID: 15254168; PMCID: PMC446112.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    119. HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Mol Cell. 2004 Jan 30; 13(2):179-90. Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D'Aloja P, Sixt M, Kolanus J, Ott M, Kolanus W, Schuler G, Baur AS. PMID: 14759364.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    120. Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp. 2004; 259:182-93; discussion 193-6, 223-5. Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou MM, Verdin E. PMID: 15171254.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    121. Acetylation of the HIV-1 Tat protein: an in vitro study. Anal Bioanal Chem. 2003 Aug; 376(7):994-1005. Dormeyer W, Dorr A, Ott M, Schnölzer M. PMID: 12904943.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    122. Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell. 2003 Jul; 12(1):167-76. Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. PMID: 12887902.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    123. Release and intercellular transfer of cell surface CD81 via microparticles. J Immunol. 2002 Nov 15; 169(10):5531-7. Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M. PMID: 12421929.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    124. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002 Aug 19; 158(4):647-57. Schwer B, North BJ, Frye RA, Ott M, Verdin E. PMID: 12186850; PMCID: PMC2174009.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansCells
    125. Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J. 2002 Jun 03; 21(11):2715-23. Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M. PMID: 12032084; PMCID: PMC125383.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    126. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell. 2002 Mar; 9(3):575-86. Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM. PMID: 11931765.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
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