Mervyn Maze

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Address1001 Potrero Ave, #1208
San Francisco CA 94110
Phone628-206-8947
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    Inflammation resolving mechanism dysregulation in postoperative cognitive decline
    NIH R01GM104194Sep 1, 2013 - Aug 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The role of cultural competency training to address health disparities in surgical settings. Br Med Bull. 2024 Mar 11. Mora R, Maze M. PMID: 38465857.
      View in: PubMed   Mentions:    Fields:    
    2. Clinical Use of Adrenergic Receptor Ligands in Acute Care Settings. Handb Exp Pharmacol. 2024 Jan 05. Langnas E, Maze M. PMID: 38177400.
      View in: PubMed   Mentions:    Fields:    
    3. Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function. Br J Anaesth. 2023 10; 131(4):694-704. Taylor J, Wu JG, Kunkel D, Parker M, Rivera C, Casey C, Naismith S, Teixeira-Pinto A, Maze M, Pearce RA, Lennertz R, Sanders RD. PMID: 37385855; PMCID: PMC10925892.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy. Cells. 2023 04 04; 12(7). DeWulf B, Minsart L, Verdonk F, Kruys V, Piagnerelli M, Maze M, Saxena S. PMID: 37048161; PMCID: PMC10093266.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect. bioRxiv. 2023 Apr 03. Weinrich JA, Liu CD, Jewell ME, Andolina CR, Bernstein MX, Benitez J, Rodriguez-Rosado S, Braz JM, Maze M, Nemenov MI, Basbaum AI. PMID: 37066151; PMCID: PMC10104003.
      View in: PubMed   Mentions:
    6. Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes. BMC Anesthesiol. 2023 03 16; 23(1):80. Saxena S, Nuyens V, Rodts C, Jamar K, Albert A, Seidel L, Cherkaoui-Malki M, Boogaerts JG, Wulff H, Maze M, Kruys V, Vamecq J. PMID: 36927341; PMCID: PMC10018926.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. Defining the role of Interleukin-6 for the development of perioperative neurocognitive disorders: Evidence from clinical and preclinical studies. Front Aging Neurosci. 2022; 14:1097606. Barreto Chang OL, Maze M. PMID: 36778590; PMCID: PMC9908597.
      View in: PubMed   Mentions: 1  
    8. Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort. Br J Anaesth. 2022 Dec 08. Fang PP, Shang ZX, Xu J, Hu J, Zhang SC, Fan YG, Lu Y, Liu XS, Maze M. PMID: 36503826.
      View in: PubMed   Mentions:    Fields:    
    9. Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study. Anesth Analg. 2023 01 01; 136(1):34-42. Zhang Y, Hu J, Zuo W, He P, Xue Q, Feng X, Zhang Y, Maze M. PMID: 36534715.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trial. Neuroradiology. 2022 Oct 17. Koskensalo K, Virtanen S, Saunavaara J, Parkkola R, Laitio R, Arola O, Hynninen M, Silvasti P, Nukarinen E, Martola J, Silvennoinen HM, Tiainen M, Roine RO, Scheinin H, Saraste A, Maze M, Vahlberg T, Laitio TT, XeHYPOTHECA Research Group. PMID: 36251060.
      View in: PubMed   Mentions: 1     Fields:    
    11. Interleukin-6 trans-signalling in hippocampal CA1 neurones mediates perioperative neurocognitive disorders in mice. Br J Anaesth. 2022 12; 129(6):923-936. Hu J, Zhang Y, Huang C, Feng X, He S, Zhang Y, Maze M. PMID: 36253222.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    12. Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle? Med Hypotheses. 2022 Nov; 168:110953. Saxena S, Wery AR, Khelif A, Nisolle ML, Lelubre C, Maze M, Biston P, Piagnerelli M. PMID: 36158528; PMCID: PMC9489961.
      View in: PubMed   Mentions: 4     Fields:    
    13. Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets. Annu Rev Pharmacol Toxicol. 2022 09 13. Barreto Chang OL, Possin KL, Maze M. PMID: 36100220.
      View in: PubMed   Mentions: 4     Fields:    
    14. Considerations for the implementation of machine learning into acute care settings. Br Med Bull. 2022 03 21; 141(1):15-32. Bishara A, Maze EH, Maze M. PMID: 35107127.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia. Eur J Anaesthesiol. 2022 03 01; 39(3):296. Hu J, Zhang Y, Maze M. PMID: 35115467.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Early postoperative risk prediction of neurocognitive decline. Br J Anaesth. 2022 Apr; 128(4):e266-e267. Saxena S, Rodts C, Nuyens V, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J. PMID: 35105461.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III. Crit Care Med. 2021 10 01; 49(10):1684-1693. Ward DS, Absalom AR, Aitken LM, Balas MC, Brown DL, Burry L, Colantuoni E, Coursin D, Devlin JW, Dexter F, Dworkin RH, Egan TD, Elliott D, Egerod I, Flood P, Fraser GL, Girard TD, Gozal D, Hopkins RO, Kress J, Maze M, Needham DM, Pandharipande P, Riker R, Sessler DI, Shafer SL, Shehabi Y, Spies C, Sun LS, Tung A, Urman RD. PMID: 33938718; PMCID: PMC8439670.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function After Abdominal Surgery in Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2021 10 01; 4(10):e2128886. Lu Y, Fang PP, Yu YQ, Cheng XQ, Feng XM, Wong GTC, Maze M, Liu XS, POGF Study Collaborators. PMID: 34648009; PMCID: PMC8517746.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    19. High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders. Cells. 2021 09 28; 10(10). Saxena S, Kruys V, De Jongh R, Vamecq J, Maze M. PMID: 34685561; PMCID: PMC8533835.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    20. Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest-A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial. Crit Care Explor. 2021 Aug; 3(8):e0502. Saraste A, Ballo H, Arola O, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T. PMID: 34345828; PMCID: PMC8323798.
      View in: PubMed   Mentions: 1  
    21. The Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders. Front Aging Neurosci. 2021; 13:671499. Saxena S, Kruys V, Vamecq J, Maze M. PMID: 34122048; PMCID: PMC8193130.
      View in: PubMed   Mentions: 21  
    22. Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial. Eur J Anaesthesiol. 2021 Mar 01; 38(Suppl 1):S9-S17. Hu J, Zhu M, Gao Z, Zhao S, Feng X, Chen J, Zhang Y, Maze M. PMID: 33122571.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    23. Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study. BMC Anesthesiol. 2020 11 14; 20(1):284. Saxena S, Rodts C, Nuyens V, Lazaron J, Sosnowski V, Verdonk F, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J. PMID: 33187477; PMCID: PMC7666527.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Robert D. Sanders, B.Sc., M.B.B.S., Ph.D., F.R.C.A., Recipient of the 2020 James E. Cottrell, M.D., Presidential Scholar Award. Anesthesiology. 2020 10 01; 133(4):720-723. Pearce RA, Maze M. PMID: 32930726.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice. Anesthesiology. 2020 08; 133(2):393-407. Li R, Lai IK, Pan JZ, Zhang P, Maze M. PMID: 32482998.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    26. Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Br J Anaesth. 2020 09; 125(3):298-307. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. PMID: 32624183; PMCID: PMC7497028.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    27. Perioperative Neurocognitive Disorder: State of the Preclinical Science. Anesthesiology. 2020 01; 132(1):55-68. Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF. PMID: 31834869; PMCID: PMC6913778.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    28. Neuroprotective Properties of Xenon. Mol Neurobiol. 2020 Jan; 57(1):118-124. Maze M, Laitio T. PMID: 31758401.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    29. Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury. Br J Anaesth. 2019 12; 123(6):827-838. Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ. PMID: 31623841; PMCID: PMC6883489.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    30. Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial. Ann Surg. 2019 08; 270(2):356-363. Zhang DF, Su X, Meng ZT, Li HL, Wang DX, Maze M, Ma D. PMID: 29742525.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    31. Protecting the Brain With Xenon Anesthesia for Neurosurgical Procedures. J Neurosurg Anesthesiol. 2019 Jan; 31(1):18-29. Rylova A, Maze M. PMID: 29470316.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    32. Specialised pro-resolving mediators: the magic bullet for perioperative neurocognitive disorders? Br J Anaesth. 2019 03; 122(3):292-294. Li R, Lai IK, Maze M. PMID: 30770043.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    33. Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesth Analg. 2018 12; 127(6):1406-1413. Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z, Perioperative Neurotoxicity Working Group. PMID: 30303868; PMCID: PMC6309612.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    34. Restoring Order to Postoperative Neurocognitive Disorders. JAMA Neurol. 2018 05 01; 75(5):535-536. Saxena S, Uchida Y, Maze M. PMID: 29459976.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    35. Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice. Anesthesiology. 2018 05; 128(5):921-931. Hu J, Vacas S, Feng X, Lutrin D, Uchida Y, Lai IK, Maze M. PMID: 29252509; PMCID: PMC6445386.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    36. Impact on the brain of the inflammatory response to surgery. Presse Med. 2018 Apr; 47(4 Pt 2):e73-e81. Saxena S, Maze M. PMID: 29656802; PMCID: PMC6445379.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    37. Past, present, and future of nitrous oxide. Br Med Bull. 2018 03 01; 125(1):103-119. Lew V, McKay E, Maze M. PMID: 29528367.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    38. Methods for Defining the Neuroprotective Properties of Xenon. Methods Enzymol. 2018; 602:273-288. Robel R, Caroccio P, Maze M. PMID: 29588034.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    39. Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice. Br J Anaesth. 2018 Mar; 120(3):537-545. Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M. PMID: 29452810; PMCID: PMC6200097.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    40. Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome. Front Immunol. 2017; 8:1768. Feng X, Uchida Y, Koch L, Britton S, Hu J, Lutrin D, Maze M. PMID: 29321779; PMCID: PMC5732173.
      View in: PubMed   Mentions: 28     Fields:    
    41. Perioperative management of the obese surgical patient. Br Med Bull. 2017 Dec 01; 124(1):135-155. Lang LH, Parekh K, Tsui BYK, Maze M. PMID: 29140418; PMCID: PMC5862330.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    42. Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial. J Am Coll Cardiol. 2017 Nov 28; 70(21):2652-2660. Arola O, Saraste A, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T, Xe-HYPOTHECA Study Group. PMID: 29169472.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    43. In Response. Anesth Analg. 2017 08; 125(2):695-696. Vacas S, Maze M. PMID: 28661919; PMCID: PMC5654546.
      View in: PubMed   Mentions:    Fields:    
    44. The immune response of the human brain to abdominal surgery. Ann Neurol. 2017 Apr; 81(4):572-582. Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granström A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI. PMID: 28253549.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    45. Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. JCI Insight. 2017 04 06; 2(7):e91229. Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK. PMID: 28405620; PMCID: PMC5374063.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    46. Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon. Neurotoxicol Teratol. 2017 Mar - Apr; 60:102-116. Alam A, Suen KC, Hana Z, Sanders RD, Maze M, Ma D. PMID: 28065636.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    47. Fragmented Sleep Enhances Postoperative Neuroinflammation but Not Cognitive Dysfunction. Anesth Analg. 2017 01; 124(1):270-276. Vacas S, Degos V, Maze M. PMID: 27755058.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    48. Initiating Mechanisms of Surgery-induced Memory Decline: The Role of HMGB1. J Clin Cell Immunol. 2016 Dec; 7(6). Vacas S, Maze M. PMID: 28674635; PMCID: PMC5493140.
      View in: PubMed   Mentions: 3  
    49. "A Time of Opportunity": Patient Safety and the Perioperative Surgical Home. Anesth Analg. 2016 12; 123(6):1348-1350. Garson LM, Vakharia S, Edwards AF, Maze M. PMID: 27644056.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    50. From Bench to Bedside and Back Again: A Personal Journey with Dexmedetomidine. Anesthesiology. 2016 09; 125(3):590-4. Maze M. PMID: 27348818; PMCID: PMC5394927.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    51. Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. J Neuroinflammation. 2016 08 30; 13(1):211. Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM. PMID: 27577265; PMCID: PMC5006595.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    52. Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet. 2016 Oct 15; 388(10054):1893-1902. Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, Zhu X, Zhu SN, Maze M, Ma D. PMID: 27542303.
      View in: PubMed   Mentions: 274     Fields:    Translation:HumansPHPublic Health
    53. The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Anesth Analg. 2016 07; 123(1):206-12. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM. PMID: 27159066; PMCID: PMC5493322.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    54. Therapeutic drug monitoring of isoniazid and rifampicin during anti-tuberculosis treatment in Auckland, New Zealand. Int J Tuberc Lung Dis. 2016 07; 20(7):955-60. Maze MJ, Paynter J, Chiu W, Hu R, Nisbet M, Lewis C. PMID: 27287650.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    55. Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA. 2016 Mar 15; 315(11):1120-8. Laitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J, Valanne L, Martola J, Silvennoinen H, Scheinin H, Harjola VP, Niiranen J, Korpi K, Varpula M, Inkinen O, Olkkola KT, Maze M, Vahlberg T, Laitio T. PMID: 26978207.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCTClinical Trials
    56. Will Xenon Be a Valuable Addition in Perioperative and Critical Care Settings? Anesth Analg. 2016 Mar; 122(3):593-596. Maze M, Pirracchio R. PMID: 26891385.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurol. 2016 02; 15(2):145-153. Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, Edwards AD. PMID: 26708675; PMCID: PMC4710577.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    58. Preclinical neuroprotective actions of xenon and possible implications for human therapeutics: a narrative review. Can J Anaesth. 2016 Feb; 63(2):212-26. Maze M. PMID: 26507536.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    59. Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome. Brain Behav Immun. 2015 Nov; 50:203-208. Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M. PMID: 26164200; PMCID: PMC4631699.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    60. Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. PLoS One. 2015; 10(5):e0126906. Feng X, Maze M, Koch LG, Britton SL, Hellman J. PMID: 25978669; PMCID: PMC4433232.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    61. Preoperative medical testing in Medicare patients undergoing cataract surgery. N Engl J Med. 2015 Apr 16; 372(16):1530-8. Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin WJ, Gelb AW, Maze M, Gropper MA, Dudley RA. PMID: 25875258; PMCID: PMC5536179.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    62. Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection. J Neuroimmunol. 2015 May 15; 282:97-103. Sanders RD, Grover V, Goulding J, Godlee A, Gurney S, Snelgrove R, Ma D, Singh S, Maze M, Hussell T. PMID: 25903735.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    63. Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Mol Med. 2015 Mar 17; 20:667-75. Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M. PMID: 25365546; PMCID: PMC4398668.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    64. In reply. Anesthesiology. 2014 Dec; 121(6):1353-4. Vacas S, Degos V, Maze M. PMID: 25405302.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    65. Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. PLoS One. 2014; 9(8):e105711. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H. PMID: 25157794; PMCID: PMC4144901.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    66. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Nov; 131(4):498-508. Han Z, Li L, Wang L, Degos V, Maze M, Su H. PMID: 25040630; PMCID: PMC4221541.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    67. Endoglin deficiency impairs stroke recovery. Stroke. 2014 Jul; 45(7):2101-6. Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H. PMID: 24876084; PMCID: PMC4118747.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    68. High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages. Anesthesiology. 2014 May; 120(5):1160-7. Vacas S, Degos V, Tracey KJ, Maze M. PMID: 24162463; PMCID: PMC3999217.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    69. Bundled payments in total joint arthroplasty: targeting opportunities for quality improvement and cost reduction. Clin Orthop Relat Res. 2014 Jan; 472(1):188-93. Bozic KJ, Ward L, Vail TP, Maze M. PMID: 23649225; PMCID: PMC3889448.
      View in: PubMed   Mentions: 103     Fields:    Translation:Humans
    70. Take off, landing, and fly anesthesia. PLoS Genet. 2013; 9(9):e1003788. Sanders RD, Maze M. PMID: 24039612; PMCID: PMC3764188.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    71. Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest. Crit Care Med. 2013 Sep; 41(9):2116-24. Arola OJ, Laitio RM, Roine RO, Grönlund J, Saraste A, Pietilä M, Airaksinen J, Perttilä J, Scheinin H, Olkkola KT, Maze M, Laitio TT. PMID: 23896830.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    72. Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice. Crit Care Med. 2013 Jul; 41(7):1627-36. Sanders RD, Godlee A, Fujimori T, Goulding J, Xin G, Salek-Ardakani S, Snelgrove RJ, Ma D, Maze M, Hussell T. PMID: 23478657; PMCID: PMC5774585.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    73. Bone fracture exacerbates murine ischemic cerebral injury. Anesthesiology. 2013 Jun; 118(6):1362-72. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H. PMID: 23438676; PMCID: PMC3987811.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    74. Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology. 2013 May; 118(5):1098-105. Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M. PMID: 23353794; PMCID: PMC5530762.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    75. The neuroinflammatory response of postoperative cognitive decline. Br Med Bull. 2013; 106:161-78. Vacas S, Degos V, Feng X, Maze M. PMID: 23558082; PMCID: PMC4990823.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    76. G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration. Ann Neurol. 2013 May; 73(5):667-78. Degos V, Peineau S, Nijboer C, Kaindl AM, Sigaut S, Favrais G, Plaisant F, Teissier N, Gouadon E, Lombet A, Saliba E, Collingridge GL, Maze M, Nicoletti F, Heijnen C, Mantz J, Kavelaars A, Gressens P. PMID: 23494575; PMCID: PMC3837433.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    77. Sleep and Anesthesia - Common mechanisms of action. Sleep Med Clin. 2013 Mar; 8(1):1-9. Vacas S, Kurien P, Maze M. PMID: 28747855; PMCID: PMC5524381.
      View in: PubMed   Mentions: 8     Fields:    
    78. Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology. 2013 Mar; 118(3):527-36. Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M. PMID: 23426204; PMCID: PMC3779063.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    79. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2013 Feb 08; 18:1481-90. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. PMID: 23296426; PMCID: PMC3576477.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    80. Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice. Influenza Other Respir Viruses. 2013 Nov; 7(6):895-9. Sanders RD, Godlee A, Goulding JC, Ma D, Maze M, Hussell T. PMID: 23279978; PMCID: PMC4634233.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    81. Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Anesthesiology. 2012 Dec; 117(6):1262-75. Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS. PMID: 23143806.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    82. Noradrenergic trespass in anesthetic and sedative states. Anesthesiology. 2012 Nov; 117(5):945-7. Sanders RD, Maze M. PMID: 23042229.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    83. The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery. Trials. 2012 Sep 27; 13:180. Coburn M, Sanders RD, Maze M, Rossaint R, HIPELD Investigators. PMID: 23016882; PMCID: PMC3488510.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    84. Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. PLoS One. 2012; 7(5):e37020. Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, Sanders RD, Robertson NJ, Johnson MR, Maze M, Ma D. PMID: 22615878; PMCID: PMC3355162.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    85. Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation. Ann Surg. 2012 May; 255(5):901-7. Sanders RD, Bottle A, Jameson SS, Mozid A, Aylin P, Edger L, Ma D, Reed MR, Walters M, Lees KR, Maze M. PMID: 22504189.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    86. Reprogramming of the infant brain by surgery with general anesthesia. Mayo Clin Proc. 2012 Feb; 87(2):110-3. Culley DJ, Maze M, Crosby G. PMID: 22305023; PMCID: PMC3497865.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    87. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011 Dec; 70(6):986-995. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M. PMID: 22190370; PMCID: PMC4556354.
      View in: PubMed   Mentions: 264     Fields:    Translation:AnimalsCells
    88. N-(Imidazolidin-2-ylidene)-1-arylmethanamine oxides: synthesis, structure and pharmacological evaluation. Arch Pharm (Weinheim). 2012 Jan; 345(1):33-42. Saczewski J, Hudson A, Laird S, Rybczynska A, Boblewski K, Lehmann A, Ma D, Maze M, Watts H, Gdaniec M. PMID: 22083875.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    89. Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice. PLoS One. 2011; 6(11):e26394. Vizcaychipi MP, Lloyd DG, Wan Y, Palazzo MG, Maze M, Ma D. PMID: 22073162; PMCID: PMC3207823.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    90. Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Neurobiol Dis. 2012 Feb; 45(2):743-50. Shu Y, Zhou Z, Wan Y, Sanders RD, Li M, Pac-Soo CK, Maze M, Ma D. PMID: 22075165.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    91. Perioperative cognitive decline in the aging population. Mayo Clin Proc. 2011 Sep; 86(9):885-93. Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M. PMID: 21878601; PMCID: PMC3257991.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    92. Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr. 2011 Nov; 159(5):851-858.e1. Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF, Eunice Kennedy Shriver National Institute of Child Health and Human Development Hypothermia Workshop. PMID: 21875719; PMCID: PMC3263823.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimals
    93. Anticipating and managing postoperative delirium and cognitive decline in adults. BMJ. 2011 Jul 20; 343:d4331. Sanders RD, Pandharipande PP, Davidson AJ, Ma D, Maze M. PMID: 21775401.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    94. Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Crit Care. 2011 Jun 24; 15(3):R153. Gu J, Sun P, Zhao H, Watts HR, Sanders RD, Terrando N, Xia P, Maze M, Ma D. PMID: 21702944; PMCID: PMC3219027.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    95. Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia. Ann Neurol. 2011 Jul; 70(1):133-50. Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Kapetanakis AB, Hristova M, Liu M, Evans S, De Vita E, Kelen D, Sanders RD, Edwards AD, Maze M, Cady EB, Raivich G, Robertson NJ. PMID: 21674582.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    96. Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Neurosci Lett. 2011 Jul 01; 498(1):63-6. Fidalgo AR, Cibelli M, White JP, Nagy I, Maze M, Ma D. PMID: 21575676.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    97. Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice. Anesthesiology. 2011 Apr; 114(4):891-900. Vizcaychipi MP, Xu L, Barreto GE, Ma D, Maze M, Giffard RG. PMID: 21317632; PMCID: PMC3063324.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    98. A clinically relevant model of perinatal global ischemic brain damage in rats. Brain Res. 2011 Apr 06; 1383:317-23. Yang T, Zhuang L, Terrando N, Wu X, Jonhson MR, Maze M, Ma D. PMID: 21281606.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    99. Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway. Can J Anaesth. 2011 Feb; 58(2):149-56. Sanders RD, Maze M. PMID: 21170622; PMCID: PMC3033507.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    100. Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice. Crit Care Med. 2010 Nov; 38(11):2190-8. Wan Y, Xu J, Meng F, Bao Y, Ge Y, Lobo N, Vizcaychipi MP, Zhang D, Gentleman SM, Maze M, Ma D. PMID: 20711073.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    101. Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20518-22. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M. PMID: 21041647; PMCID: PMC2996666.
      View in: PubMed   Mentions: 321     Fields:    Translation:AnimalsCells
    102. Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol. 2010 Sep; 68(3):360-8. Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M. PMID: 20818791; PMCID: PMC4836445.
      View in: PubMed   Mentions: 335     Fields:    Translation:Animals
    103. Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia. Anesthesiology. 2010 Aug; 113(2):360-8. Shu Y, Patel SM, Pac-Soo C, Fidalgo AR, Wan Y, Maze M, Ma D. PMID: 20613483.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    104. Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term. Anesthesiology. 2010 Jul; 113(1):233-49. Sanders RD, Manning HJ, Robertson NJ, Ma D, Edwards AD, Hagberg H, Maze M. PMID: 20526192.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    105. Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells. Exp Biol Med (Maywood). 2010 Jul; 235(7):886-91. Rizvi M, Jawad N, Li Y, Vizcaychipi MP, Maze M, Ma D. PMID: 20472713.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    106. The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care. 2010; 14(3):R88. Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M. PMID: 20470406; PMCID: PMC2911722.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    107. Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Crit Care. 2010; 14(2):R38. Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW, MENDS investigators. PMID: 20233428; PMCID: PMC2887145.
      View in: PubMed   Mentions: 128     Fields:    Translation:Humans
    108. Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. Anesthesiology. 2010 Mar; 112(3):729-41. White JP, Cibelli M, Rei Fidalgo A, Paule CC, Noormohamed F, Urban L, Maze M, Nagy I. PMID: 20179512.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    109. Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener. Anesthesiology. 2010 Mar; 112(3):623-30. Bantel C, Maze M, Trapp S. PMID: 20179498; PMCID: PMC2935677.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    110. Argon neuroprotection. Crit Care. 2010; 14(1):117. Sanders RD, Ma D, Maze M. PMID: 20236500; PMCID: PMC2875517.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    111. Neuroinflammation and postoperative cognitive dysfunction: can anaesthesia be therapeutic? Eur J Anaesthesiol. 2010 Jan; 27(1):3-5. Sanders RD, Maze M. PMID: 19996712.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    112. Does correcting the numbers improve long-term outcome? Anesthesiology. 2009 Sep; 111(3):475-7. Sanders RD, Maze M. PMID: 19672169.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    113. Sedation improves early outcome in severely septic Sprague Dawley rats. Crit Care. 2009; 13(4):R136. Qiao H, Sanders RD, Ma D, Wu X, Maze M. PMID: 19691839; PMCID: PMC2750194.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    114. Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury. Neurosci Lett. 2009 Sep 04; 460(3):232-6. Jawad N, Rizvi M, Gu J, Adeyi O, Tao G, Maze M, Ma D. PMID: 19500647.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    115. Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology. 2009 May; 110(5):1077-85. Sanders RD, Xu J, Shu Y, Januszewski A, Halder S, Fidalgo A, Sun P, Hossain M, Ma D, Maze M. PMID: 19352168.
      View in: PubMed   Mentions: 153     Fields:    Translation:Animals
    116. Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology. 2009 May; 110(5):986-95. Bantel C, Maze M, Trapp S. PMID: 19352153; PMCID: PMC2930813.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    117. Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. J Am Soc Nephrol. 2009 Apr; 20(4):713-20. Ma D, Lim T, Xu J, Tang H, Wan Y, Zhao H, Hossain M, Maxwell PH, Maze M. PMID: 19144758; PMCID: PMC2663824.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    118. Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model. Anesthesiology. 2008 Nov; 109(5):782-9. Luo Y, Ma D, Ieong E, Sanders RD, Yu B, Hossain M, Maze M. PMID: 18946288.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    119. Xenon up-regulates several genes that are not up-regulated by nitrous oxide. J Neurosurg Anesthesiol. 2008 Oct; 20(4):226-32. Valleggi S, Cavazzana AO, Bernardi R, Ma D, Natale G, Maze M, Cattano D, Davide C, Giunta F. PMID: 18812885.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    120. Biologic effects of nitrous oxide: a mechanistic and toxicologic review. Anesthesiology. 2008 Oct; 109(4):707-22. Sanders RD, Weimann J, Maze M. PMID: 18813051.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsPHPublic Health
    121. General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord. Anesth Analg. 2008 Jun; 106(6):1708-11. Sanders RD, Xu J, Shu Y, Fidalgo A, Ma D, Maze M. PMID: 18499598.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    122. Role of endogenous sleep-wake and analgesic systems in anesthesia. J Comp Neurol. 2008 Jun 01; 508(4):648-62. Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. PMID: 18383504; PMCID: PMC4924624.
      View in: PubMed   Mentions: 92     Fields:    Translation:Animals
    123. Expecting the unexpected. Anesth Analg. 2008 Jun; 106(6):1605-6. Talke PO, Maze M. PMID: 18499586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    124. Xenon induces transcription of ADNP in neonatal rat brain. Neurosci Lett. 2008 Aug 08; 440(3):217-21. Cattano D, Valleggi S, Ma D, Kastsiuchenka O, Abramo A, Sun P, Cavazzana AO, Natale G, Maze M, Giunta F. PMID: 18571851.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    125. The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury. Crit Care Med. 2008 Feb; 36(2):588-95. Coburn M, Maze M, Franks NP. PMID: 18216607.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    126. Taking the lead in research into postoperative cognitive dysfunction. Anesthesiology. 2008 Jan; 108(1):1-2. Maze M, Cibelli M, Grocott HP. PMID: 18156872.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    127. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007 Dec 12; 298(22):2644-53. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW. PMID: 18073360.
      View in: PubMed   Mentions: 435     Fields:    Translation:Humans
    128. Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Anesthesiology. 2007 Nov; 107(5):756-67. Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP. PMID: 18073551.
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    129. Translational research: addressing problems facing the anesthesiologist. Anesth Analg. 2007 Oct; 105(4):899-901. Sanders RD, Maze M. PMID: 17898363.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    130. Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology. 2007 Apr; 106(4):746-53. Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Ong LP, Shu Y, Franks NP, Maze M. PMID: 17413912.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    131. Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology. 2007 Mar; 106(3):436-43. Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M. PMID: 17325501.
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    132. Special issue on postoperative cognitive dysfunction: selected reports from the journal-sponsored symposium. Anesthesiology. 2007 Mar; 106(3):418-20. Maze M, Todd MM. PMID: 17325497.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    133. Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Anesthesiology. 2007 Mar; 106(3):572-90. Newman S, Stygall J, Hirani S, Shaefi S, Maze M. PMID: 17325517.
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    134. Alpha2-adrenoceptor agonists. Curr Opin Investig Drugs. 2007 Jan; 8(1):25-33. Sanders RD, Maze M. PMID: 17263182.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    135. The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Anesth Analg. 2006 Dec; 103(6):1459-63. Sakamoto S, Nakao S, Masuzawa M, Inada T, Maze M, Franks NP, Shingu K. PMID: 17122223.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    136. Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Neurosci Lett. 2006 Dec 01; 409(2):128-33. Rajakumaraswamy N, Ma D, Hossain M, Sanders RD, Franks NP, Maze M. PMID: 17052852.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    137. Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon. Anesthesiology. 2006 Jul; 105(1):187-97. Preckel B, Weber NC, Sanders RD, Maze M, Schlack W. PMID: 16810011.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    138. The role of the craniospinal nerves in mediating the antinociceptive effect of transcranial electrostimulation in the rat. Anesth Analg. 2006 Jun; 102(6):1775-80. Nekhendzy V, Davies MF, Lemmens HJ, Maze M. PMID: 16717325.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    139. A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. Anesthesiology. 2006 May; 104(5):1040-6. Holdcroft A, Maze M, Doré C, Tebbs S, Thompson S. PMID: 16645457.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    140. Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study. Anesthesiology. 2006 Mar; 104(3):458-65. Lockwood GG, Franks NP, Downie NA, Taylor KM, Maze M. PMID: 16508392.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    141. Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. J Cereb Blood Flow Metab. 2006 Feb; 26(2):199-208. Ma D, Hossain M, Pettet GK, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M. PMID: 16034370.
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    142. Expansion of gas bubbles by nitrous oxide and xenon. Anesthesiology. 2006 Feb; 104(2):299-302. Benavides R, Maze M, Franks NP. PMID: 16436849.
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    143. Anaesthesia induced neuroprotection. Best Pract Res Clin Anaesthesiol. 2005 Sep; 19(3):461-74. Sanders RD, Ma D, Maze M. PMID: 16013694.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    144. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol. 2005 Aug; 58(2):182-93. Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M. PMID: 16049939.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    145. Xenon and the inflammatory response to cardiopulmonary bypass in the rat. J Cardiothorac Vasc Anesth. 2005 Aug; 19(4):488-93. Clark JA, Ma D, Homi HM, Maze M, Grocott HP. PMID: 16085255.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    146. Xenon: from stranger to guardian. Curr Opin Anaesthesiol. 2005 Aug; 18(4):405-11. Sanders RD, Maze M. PMID: 16534266.
      View in: PubMed   Mentions: 11     Fields:    
    147. Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats. Anesth Analg. 2005 May; 100(5):1295-1302. Sanders RD, Giombini M, Ma D, Ohashi Y, Hossain M, Fujinaga M, Maze M. PMID: 15845672.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    148. Xenon: elemental anaesthesia in clinical practice. Br Med Bull. 2004; 71:115-35. Sanders RD, Ma D, Maze M. PMID: 15728132.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    149. alpha2-Adrenoceptor agonists: shedding light on neuroprotection? Br Med Bull. 2004; 71:77-92. Ma D, Rajakumaraswamy N, Maze M. PMID: 15684247.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    150. Dexmedetomidine and opioid interactions: defining the role of dexmedetomidine for intensive care unit sedation. Anesthesiology. 2004 Nov; 101(5):1059-61. Maze M, Angst MS. PMID: 15505438.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    151. Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. Eur J Pharmacol. 2004 Oct 11; 502(1-2):87-97. Ma D, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze M. PMID: 15464093.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    152. Dexmedetomidine: another arrow for the clinician's quiver. Anesthesiology. 2004 Sep; 101(3):568-70. Ebert T, Maze M. PMID: 15329580.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    153. Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Anesthesiology. 2004 Sep; 101(3):744-52. Angst MS, Ramaswamy B, Davies MF, Maze M. PMID: 15329600.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    154. Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia. Anesthesiology. 2004 Jun; 100(6):1341-2. Nelson LE, Franks NP, Maze M. PMID: 15166550.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    155. Xenon exerts age-independent antinociception in Fischer rats. Anesthesiology. 2004 May; 100(5):1313-8. Ma D, Sanders RD, Halder S, Rajakumaraswamy N, Franks NP, Maze M. PMID: 15114234.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    156. Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans. Neuroimage. 2004 May; 22(1):315-22. Coull JT, Jones ME, Egan TD, Frith CD, Maze M. PMID: 15110021.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCTClinical Trials
    157. Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action. Anesthesiology. 2004 Apr; 100(4):894-904. Dawson C, Ma D, Chow A, Maze M. PMID: 15087625.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    158. The antinociceptive effect of transcranial electrostimulation with combined direct and alternating current in freely moving rats. Anesth Analg. 2004 Mar; 98(3):730-7, table of contents. Nekhendzy V, Fender CP, Davies MF, Lemmens HJ, Kim MS, Bouley DM, Maze M. PMID: 14980928.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    159. The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology. 2003 Oct; 99(4):876-81. Homi HM, Yokoo N, Ma D, Warner DS, Franks NP, Maze M, Grocott HP. PMID: 14508320.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    160. Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats. Anesthesiology. 2003 Oct; 99(4):947-54. Ohashi Y, Guo T, Orii R, Maze M, Fujinaga M. PMID: 14508330.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    161. Corticotropin-releasing factor mediates the antinociceptive action of nitrous oxide in rats. Anesthesiology. 2003 Sep; 99(3):708-15. Sawamura S, Obara M, Takeda K, Maze M, Hanaoka K. PMID: 12960557.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    162. Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model. Anesthesiology. 2003 Sep; 99(3):748-51. Ma D, Hossain M, Rajakumaraswamy N, Franks NP, Maze M. PMID: 12960563.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    163. GABAergic interneurons at supraspinal and spinal levels differentially modulate the antinociceptive effect of nitrous oxide in Fischer rats. Anesthesiology. 2003 May; 98(5):1223-30. Orii R, Ohashi Y, Halder S, Giombini M, Maze M, Fujinaga M. PMID: 12717145.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    164. Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2003 Mar; 98(3):690-8. Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP. PMID: 12606913.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    165. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 2003 Feb; 98(2):428-36. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M. PMID: 12552203.
      View in: PubMed   Mentions: 277     Fields:    Translation:Animals
    166. Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology. 2002 Jun; 96(6):1485-91. Wilhelm S, Ma D, Maze M, Franks NP. PMID: 12170064.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    167. Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype. Anesthesiology. 2002 Jun; 96(6):1420-6. Takada K, Clark DJ, Davies MF, Tonner PH, Krause TK, Bertaccini E, Maze M. PMID: 12170055.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    168. Neurobiology of nitrous oxide-induced antinociceptive effects. Mol Neurobiol. 2002 Apr; 25(2):167-89. Fujinaga M, Maze M. PMID: 11936558.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    169. Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Anesthesiology. 2002 Feb; 96(2):367-74. Kingery WS, Agashe GS, Guo TZ, Sawamura S, Davies MF, Clark JD, Kobilka BK, Maze M. PMID: 11818770.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    170. Capsaicin sensitive afferents mediate the development of heat hyperalgesia and hindpaw edema after sciatic section in rats. Neurosci Lett. 2002 Jan 18; 318(1):39-43. Kingery WS, Agashe GS, Guo TZ, Davies MF, Clark JD, Maze M. PMID: 11786220.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    171. Developmental variation in nitrous oxide-induced c-fos expression in Fischer rat spinal cord. Anesthesiology. 2002 Jan; 96(1):249-51. Hashimoto T, Ohashi Y, Nelson LE, Maze M, Fujinaga M. PMID: 11753029.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    172. The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain. 2000 Apr; 85(3):345-358. Kingery WS, Guo TZ, Davies FM, Limbird L, Maze M. PMID: 10781908.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    173. Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds. Pain. 1999 Apr; 80(3):555-566. Kingery WS, Castellote JM, Maze M. PMID: 10342417.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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