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Michael Fischbach, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentBioengineering
Address1700 4th Street
San Francisco CA 94158
Phone415-514-9435
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    Collapse Biography 
    Collapse Awards and Honors
    Sandler Foundation2010  - 2015Opportunity Award, Program for Breakthrough Biomedical Research
    Global Probiotics Council2010Young Investigator Grant For Probiotics Research
    NIH2011  - 2016New Innovator Award
    W.M. Keck Foundation2011  - 2014Medical Research Award
    David and Lucile Packard Foundation2011  - 2016Fellowship for Science and Engineering

    Collapse Overview 
    Collapse Overview
    Michael Fischbach is an Associate Professor in the Department of Bioengineering and Therapeutic Sciences at UCSF and a member of the California Institute for Quantitative Biosciences (QB3). Fischbach is a recipient of the NIH Director's New Innovator Award, a Fellowship for Science and Engineering from the David and Lucille Packard Foundation, a Medical Research Award from the W.M. Keck Foundation, a Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease award, a Glenn Award for Research in Biological Mechanisms of Aging, and the Young Investigator Grant for Probiotics Research from the Global Probiotics Council. His laboratory uses a combination of genomics and chemistry to identify and characterize small molecules from microbes, with an emphasis on the human microbiome. Fischbach received his Ph.D. as a John and Fannie Hertz Foundation Fellow in chemistry from Harvard in 2007, where he studied the role of iron acquisition in bacterial pathogenesis and the biosynthesis of antibiotics. Before coming to UCSF, he spent two years as an independent fellow at Massachusetts General Hospital coordinating a collaborative effort based at the Broad Institute to develop genomics-based approaches to the discovery of small molecules from microbes. Fischbach is a member of the scientific advisory boards of NGM Biopharmaceuticals, Reckitt Benckiser, Symbiota, and Warp Drive Bio, and a member of Genentech's Scientific Resource Board.


    Collapse Research 
    Collapse Research Activities and Funding
    Identification and characterization of natural products from the human microbiota
    NIH/NIDDK R01DK110174Sep 21, 2016 - Jul 31, 2020
    Role: Principal Investigator
    A complete map of the top 100 molecules from the gut microbiome
    NIH/NIDDK DP1DK113598Sep 8, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Dietary and Microbial Reprogramming of Intestinal Microbiota-Produced Metabolites
    NIH/NIDDK R01DK101674Sep 18, 2014 - Aug 31, 2019
    Role: Co-Principal Investigator
    Antibiotics from nose and throat commensals that impact pathogen colonization
    NIH/NIAID R01AI101018Aug 20, 2012 - Dec 31, 2021
    Role: Co-Principal Investigator
    Natural products from a human-asssociated fungal pathogen
    NIH/NIAID R21AI101722Jul 1, 2012 - Jun 30, 2014
    Role: Co-Principal Investigator
    Identifying and characterizing small molecules from the human microbiome
    NIH DP2OD007290Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator

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    Collapse In The News
    Collapse Global Health
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach M. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. 2017 Jan 26; 168(3):517-526.e18. PMID: 28111075.
      View in: PubMed
    2. Devlin AS, Marcobal A, Dodd D, Nayfach S, Plummer N, Meyer T, Pollard KS, Sonnenburg JL, Fischbach M. Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota. Cell Host Microbe. 2016 Dec 14; 20(6):709-715. PMID: 27916477.
      View in: PubMed
    3. Fischbach M, Segre JA. Signaling in Host-Associated Microbial Communities. Cell. 2016 Mar 10; 164(6):1288-300. PMID: 26967294.
      View in: PubMed
    4. Smanski MJ, Zhou H, Claesen J, Shen B, Fischbach M, Voigt CA. Synthetic biology to access and expand nature's chemical diversity. Nat Rev Microbiol. 2016 Feb 15; 14(3):135-49. PMID: 26876034.
      View in: PubMed
    5. Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach M, Rosenblum MD. A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity. 2015 Nov 17; 43(5):1011-21. PMID: 26588783; PMCID: PMC4654993 [Available on 11/17/16].
    6. Wilks J, Lien E, Jacobson AN, Fischbach M, Qureshi N, Chervonsky AV, Golovkina TV. Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission. Cell Host Microbe. 2015 Oct 14; 18(4):456-62. PMID: 26468748.
      View in: PubMed
    7. Taketani M, Donia MS, Jacobson AN, Lambris JD, Fischbach M. A Phase-Variable Surface Layer from the Gut Symbiont Bacteroides thetaiotaomicron. MBio. 2015; 6(5):e01339-15. PMID: 26419879; PMCID: PMC4611039.
    8. Medema MH, Fischbach M. Computational approaches to natural product discovery. Nat Chem Biol. 2015 Sep; 11(9):639-48. PMID: 26284671.
      View in: PubMed
    9. Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach M, Linington RG. Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16; 10(10):2373-81. PMID: 26270237.
      View in: PubMed
    10. Donia MS, Fischbach M. HUMAN MICROBIOTA. Small molecules from the human microbiota. Science. 2015 Jul 24; 349(6246):1254766. PMID: 26206939; PMCID: PMC4641445 [Available on 01/24/16].
    11. Devlin AS, Fischbach M. A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat Chem Biol. 2015 Sep; 11(9):685-90. PMID: 26192599; PMCID: PMC4543561 [Available on 03/01/16].
    12. Hadjithomas M, Chen IM, Chu K, Ratner A, Palaniappan K, Szeto E, Huang J, Reddy TB, Cimermancic P, Fischbach M, Ivanova NN, Markowitz VM, Kyrpides NC, Pati A. IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites. MBio. 2015; 6(4):e00932. PMID: 26173699; PMCID: PMC4502231.
    13. Nayfach S, Fischbach M, Pollard KS. MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome. Bioinformatics. 2015 Oct 15; 31(20):3368-70. PMID: 26104745; PMCID: PMC4595903.
    14. Weber T, Blin K, Duddela S, Krug D, Kim HU, Bruccoleri R, Lee SY, Fischbach M, Müller R, Wohlleben W, Breitling R, Takano E, Medema MH. antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res. 2015 Jul 1; 43(W1):W237-43. PMID: 25948579; PMCID: PMC4489286.
    15. Medema MH, Cimermancic P, Sali A, Takano E, Fischbach M. A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis. PLoS Comput Biol. 2014 Dec; 10(12):e1004016. PMID: 25474254; PMCID: PMC4256081.
    16. Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach M. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe. 2014 Oct 8; 16(4):495-503. PMID: 25263219; PMCID: PMC4260654.
    17. Donia MS, Cimermancic P, Schulze CJ, Wieland Brown LC, Martin J, Mitreva M, Clardy J, Linington RG, Fischbach M. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell. 2014 Sep 11; 158(6):1402-14. PMID: 25215495; PMCID: PMC4164201.
    18. Claesen J, Fischbach M. Synthetic microbes as drug delivery systems. ACS Synth Biol. 2015 Apr 17; 4(4):358-64. PMID: 25079685; PMCID: PMC4410909.
    19. Wollenberg MS, Claesen J, Escapa IF, Aldridge KL, Fischbach M, Lemon KP. Propionibacterium-produced coproporphyrin III induces Staphylococcus aureus aggregation and biofilm formation. MBio. 2014; 5(4):e01286-14. PMID: 25053784; PMCID: PMC4120196.
    20. Cimermancic P, Medema MH, Claesen J, Kurita K, Wieland Brown LC, Mavrommatis K, Pati A, Godfrey PA, Koehrsen M, Clardy J, Birren BW, Takano E, Sali A, Linington RG, Fischbach M. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell. 2014 Jul 17; 158(2):412-21. PMID: 25036635; PMCID: PMC4123684.
    21. Lau W, Fischbach M, Osbourn A, Sattely ES. Key applications of plant metabolic engineering. PLoS Biol. 2014 Jun; 12(6):e1001879. PMID: 24915445; PMCID: PMC4051588.
    22. Kraal L, Abubucker S, Kota K, Fischbach M, Mitreva M. The prevalence of species and strains in the human microbiome: a resource for experimental efforts. PLoS One. 2014; 9(5):e97279. PMID: 24827833; PMCID: PMC4020798.
    23. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach M, Biddinger SB, Dutton RJ, Turnbaugh PJ. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014 Jan 23; 505(7484):559-63. PMID: 24336217; PMCID: PMC3957428.
    24. Scharschmidt TC, Fischbach M. What Lives On Our Skin: Ecology, Genomics and Therapeutic Opportunities Of the Skin Microbiome. Drug Discov Today Dis Mech. 2013 Dec 1; 10(3-4). PMID: 24273587.
      View in: PubMed
    25. Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach M. Production of a-galactosylceramide by a prominent member of the human gut microbiota. PLoS Biol. 2013 Jul; 11(7):e1001610. PMID: 23874157; PMCID: PMC3712910.
    26. Marcobal A, Kashyap PC, Nelson TA, Aronov PA, Donia MS, Spormann A, Fischbach M, Sonnenburg JL. A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice. ISME J. 2013 Oct; 7(10):1933-43. PMID: 23739052; PMCID: PMC3965317.
    27. Blin K, Medema MH, Kazempour D, Fischbach M, Breitling R, Takano E, Weber T. antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res. 2013 Jul; 41(Web Server issue):W204-12. PMID: 23737449; PMCID: PMC3692088.
    28. Fischbach M, Bluestone JA, Lim WA. Cell-based therapeutics: the next pillar of medicine. Sci Transl Med. 2013 Apr 3; 5(179):179ps7. PMID: 23552369; PMCID: PMC3772767.
    29. Djonovic S, Urbach JM, Drenkard E, Bush J, Feinbaum R, Ausubel JL, Traficante D, Risech M, Kocks C, Fischbach M, Priebe GP, Ausubel FM. Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants. PLoS Pathog. 2013 Mar; 9(3):e1003217. PMID: 23505373; PMCID: PMC3591346.
    30. Donia MS, Fischbach M. Dyeing to learn more about the gut microbiota. Cell Host Microbe. 2013 Feb 13; 13(2):119-20. PMID: 23414750; PMCID: PMC3690940.
    31. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach M, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan; 30(1):108-60. PMID: 23165928; PMCID: PMC3954855.
    32. Rath CM, Alexandrov T, Higginbottom SK, Song J, Milla ME, Fischbach M, Sonnenburg JL, Dorrestein PC. Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations. Anal Chem. 2012 Nov 6; 84(21):9259-67. PMID: 23009651; PMCID: PMC3711173.
    33. Holmes TC, May AE, Zaleta-Rivera K, Ruby JG, Skewes-Cox P, Fischbach M, DeRisi JL, Iwatsuki M, Omura S, Khosla C. Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor. J Am Chem Soc. 2012 Oct 24; 134(42):17797-806. PMID: 23030602; PMCID: PMC3483642.
    34. Lemon KP, Armitage GC, Relman DA, Fischbach M. Microbiota-targeted therapies: an ecological perspective. Sci Transl Med. 2012 Jun 6; 4(137):137rv5. PMID: 22674555.
      View in: PubMed
    35. Gonzalez DJ, Xu Y, Yang YL, Esquenazi E, Liu WT, Edlund A, Duong T, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V, Dorrestein PC. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. J Proteomics. 2012 Aug 30; 75(16):5069-76. PMID: 22641157; PMCID: PMC3543690.
    36. Fischbach M, Sonnenburg JL. Eating for two: how metabolism establishes interspecies interactions in the gut. Cell Host Microbe. 2011 Oct 20; 10(4):336-47. PMID: 22018234; PMCID: PMC3225337.
    37. Assassi S, Leyva AL, Mayes MD, Sharif R, Nair DK, Fischbach M, Nguyen N, Reveille JD, Gonzalez EB, McNearney TA. Predictors of fatigue severity in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort. PLoS One. 2011; 6(10):e26061. PMID: 22022507; PMCID: PMC3193535.
    38. Kersten RD, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, Fischbach M, Moore BS, Dorrestein PC. A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol. 2011 Nov; 7(11):794-802. PMID: 21983601; PMCID: PMC3258187.
    39. Fischbach M. Combination therapies for combating antimicrobial resistance. Curr Opin Microbiol. 2011 Oct; 14(5):519-23. PMID: 21900036; PMCID: PMC3196371.
    40. Medema MH, Blin K, Cimermancic P, de Jager V, Zakrzewski P, Fischbach M, Weber T, Takano E, Breitling R. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res. 2011 Jul; 39(Web Server issue):W339-46. PMID: 21672958; PMCID: PMC3125804.
    41. Sonnenburg JL, Fischbach M. Community health care: therapeutic opportunities in the human microbiome. Sci Transl Med. 2011 Apr 13; 3(78):78ps12. PMID: 21490274; PMCID: PMC3287364.
    42. Fischbach M, Voigt CA. Prokaryotic gene clusters: a rich toolbox for synthetic biology. Biotechnol J. 2010 Dec; 5(12):1277-96. PMID: 21154668; PMCID: PMC3904232.
    43. Song JY, Jeong H, Yu DS, Fischbach M, Park HS, Kim JJ, Seo JS, Jensen SE, Oh TK, Lee KJ, Kim JF. Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites. J Bacteriol. 2010 Dec; 192(23):6317-8. PMID: 20889745; PMCID: PMC2981214.
    44. Zimmermann M, Fischbach M. A family of pyrazinone natural products from a conserved nonribosomal peptide synthetase in Staphylococcus aureus. Chem Biol. 2010 Sep 24; 17(9):925-30. PMID: 20851341.
      View in: PubMed
    45. Fischbach M, Krogan NJ. The next frontier of systems biology: higher-order and interspecies interactions. Genome Biol. 2010; 11(5):208. PMID: 20441613; PMCID: PMC2898071.
    46. Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach M, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell. 2010 Apr 2; 141(1):69-80. PMID: 20371346; PMCID: PMC2851638.
    47. Dawlaty J, Zhang X, Fischbach M, Clardy J. Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases. J Nat Prod. 2010 Mar 26; 73(3):441-6. PMID: 20041689; PMCID: PMC2846032.
    48. Walsh CT, Fischbach M. Natural products version 2.0: connecting genes to molecules. J Am Chem Soc. 2010 Mar 3; 132(8):2469-93. PMID: 20121095; PMCID: PMC2828520.
    49. Haas BJ, Kamoun S, Zody MC, Jiang RH, Handsaker RE, Cano LM, Grabherr M, Kodira CD, Raffaele S, Torto-Alalibo T, Bozkurt TO, Ah-Fong AM, Alvarado L, Anderson VL, Armstrong MR, Avrova A, Baxter L, Beynon J, Boevink PC, Bollmann SR, Bos JI, Bulone V, Cai G, Cakir C, Carrington JC, Chawner M, Conti L, Costanzo S, Ewan R, Fahlgren N, Fischbach M, Fugelstad J, Gilroy EM, Gnerre S, Green PJ, Grenville-Briggs LJ, Griffith J, Grünwald NJ, Horn K, Horner NR, Hu CH, Huitema E, Jeong DH, Jones AM, Jones JD, Jones RW, Karlsson EK, Kunjeti SG, Lamour K, Liu Z, Ma L, Maclean D, Chibucos MC, McDonald H, McWalters J, Meijer HJ, Morgan W, Morris PF, Munro CA, O'Neill K, Ospina-Giraldo M, Pinzón A, Pritchard L, Ramsahoye B, Ren Q, Restrepo S, Roy S, Sadanandom A, Savidor A, Schornack S, Schwartz DC, Schumann UD, Schwessinger B, Seyer L, Sharpe T, Silvar C, Song J, Studholme DJ, Sykes S, Thines M, van de Vondervoort PJ, Phuntumart V, Wawra S, Weide R, Win J, Young C, Zhou S, Fry W, Meyers BC, van West P, Ristaino J, Govers F, Birch PR, Whisson SC, Judelson HS, Nusbaum C. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature. 2009 Sep 17; 461(7262):393-8. PMID: 19741609.
      View in: PubMed
    50. Fischbach M, Walsh CT. Antibiotics for emerging pathogens. Science. 2009 Aug 28; 325(5944):1089-93. PMID: 19713519; PMCID: PMC2802854.
    51. Fischbach M. Antibiotics from microbes: converging to kill. Curr Opin Microbiol. 2009 Oct; 12(5):520-7. PMID: 19695947; PMCID: PMC3176294.
    52. Walsh CT, Fischbach M. New ways to squash superbugs. Sci Am. 2009 Jul; 301(1):44-51. PMID: 19555023.
      View in: PubMed
    53. Clardy J, Fischbach M, Currie CR. The natural history of antibiotics. Curr Biol. 2009 Jun 9; 19(11):R437-41. PMID: 19515346; PMCID: PMC2731226.
    54. Wieland Brown LC, Acker MG, Clardy J, Walsh CT, Fischbach M. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2549-53. PMID: 19196969; PMCID: PMC2650375.
    55. Walsh CT, Fischbach M. Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1689-90. PMID: 19193851; PMCID: PMC2644097.
    56. López D, Fischbach M, Chu F, Losick R, Kolter R. Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis. Proc Natl Acad Sci U S A. 2009 Jan 6; 106(1):280-5. PMID: 19114652; PMCID: PMC2629187.
    57. Sattely ES, Fischbach M, Walsh CT. Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. Nat Prod Rep. 2008 Aug; 25(4):757-93. PMID: 18663394.
      View in: PubMed
    58. Stinear TP, Seemann T, Harrison PF, Jenkin GA, Davies JK, Johnson PD, Abdellah Z, Arrowsmith C, Chillingworth T, Churcher C, Clarke K, Cronin A, Davis P, Goodhead I, Holroyd N, Jagels K, Lord A, Moule S, Mungall K, Norbertczak H, Quail MA, Rabbinowitsch E, Walker D, White B, Whitehead S, Small PL, Brosch R, Ramakrishnan L, Fischbach M, Parkhill J, Cole ST. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res. 2008 May; 18(5):729-41. PMID: 18403782; PMCID: PMC2336800.
    59. Fischbach M, Walsh CT, Clardy J. The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4601-8. PMID: 18216259; PMCID: PMC2290807.
    60. Walsh CT, Fischbach M. Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics. Angew Chem Int Ed Engl. 2008; 47(31):5700-2. PMID: 18576462; PMCID: PMC2603329.
    61. Nolan EM, Fischbach M, Koglin A, Walsh CT. Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. J Am Chem Soc. 2007 Nov 21; 129(46):14336-47. PMID: 17973380; PMCID: PMC2522288.
    62. Fischbach M, Lai JR, Roche ED, Walsh CT, Liu DR. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):11951-6. PMID: 17620609; PMCID: PMC1924594.
    63. Fischbach M, Clardy J. One pathway, many products. Nat Chem Biol. 2007 Jul; 3(7):353-5. PMID: 17576415.
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    64. Butcher RA, Schroeder FC, Fischbach M, Straight PD, Kolter R, Walsh CT, Clardy J. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1506-9. PMID: 17234808; PMCID: PMC1785240.
    65. Straight PD, Fischbach M, Walsh CT, Rudner DZ, Kolter R. A singular enzymatic megacomplex from Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 2; 104(1):305-10. PMID: 17190806; PMCID: PMC1765455.
    66. Clardy J, Fischbach M, Walsh CT. New antibiotics from bacterial natural products. Nat Biotechnol. 2006 Dec; 24(12):1541-50. PMID: 17160060.
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    67. Fischbach M, Walsh CT. Biochemistry. Directing biosynthesis. Science. 2006 Oct 27; 314(5799):603-5. PMID: 17068249.
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    68. Fischbach M, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, Smith KD. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16502-7. PMID: 17060628; PMCID: PMC1637611.
    69. Lai JR, Fischbach M, Liu DR, Walsh CT. Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. J Am Chem Soc. 2006 Aug 30; 128(34):11002-3. PMID: 16925399.
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    70. Larsen NA, Lin H, Wei R, Fischbach M, Walsh CT. Structural characterization of enterobactin hydrolase IroE. Biochemistry. 2006 Aug 29; 45(34):10184-90. PMID: 16922493.
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    71. Jin M, Fischbach M, Clardy J. A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid. J Am Chem Soc. 2006 Aug 23; 128(33):10660-1. PMID: 16910643; PMCID: PMC2529255.
    72. Fischbach M, Walsh CT. Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. Chem Rev. 2006 Aug; 106(8):3468-96. PMID: 16895337.
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    73. Lin H, Fischbach M, Gatto GJ, Liu DR, Walsh CT. Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. J Am Chem Soc. 2006 Jul 26; 128(29):9324-5. PMID: 16848455.
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    74. Sharma SV, Fischbach M, Haber DA, Settleman J. "Oncogenic shock": explaining oncogene addiction through differential signal attenuation. Clin Cancer Res. 2006 Jul 15; 12(14 Pt 2):4392s-4395s. PMID: 16857816.
      View in: PubMed
    75. Lai JR, Fischbach M, Liu DR, Walsh CT. A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. Proc Natl Acad Sci U S A. 2006 Apr 4; 103(14):5314-9. PMID: 16567620; PMCID: PMC1459352.
    76. Fischbach M, Lin H, Liu DR, Walsh CT. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat Chem Biol. 2006 Mar; 2(3):132-8. PMID: 16485005.
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    77. Luo M, Lin H, Fischbach M, Liu DR, Walsh CT, Groves JT. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. ACS Chem Biol. 2006 Feb 17; 1(1):29-32. PMID: 17163637.
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    78. Dorrestein PC, Blackhall J, Straight PD, Fischbach M, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 2006 Feb 14; 45(6):1537-46. PMID: 16460000; PMCID: PMC2565507.
    79. Fischbach M, Settleman J. Regulation of the nucleotide state of oncogenic ras proteins by nucleoside diphosphate kinase. Methods Enzymol. 2006; 407:33-45. PMID: 16757312.
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    80. Garstecki P, J Fuerstman M, Fischbach M, Sia SK, Whitesides GM. Mixing with bubbles: a practical technology for use with portable microfluidic devices. Lab Chip. 2006 Feb; 6(2):207-12. PMID: 16450029.
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