Michael Jacob, MD, PhD

Title(s)Assistant Professor, Psychiatry
SchoolSchool of Medicine
Address1550 Fourth Street
San Francisco CA 94158
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences

    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, CABA2004Molecular and Cell Biology
    University of Rochester , Rochester, NYPhD2011Neurobiology and Anatomy
    University of Rochester, Rochester, NYMD2013School of Medicine
    University of California, San Francisco, CA2017Residency in Psychiatry
    Veterans Affairs Health Care System, San Francisco, CA2019Fellow in Psychiatric Research /Neuroscience
    University of California, San Francisco, CA2020Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Stressed heart-brain communication in Veterans with schizophrenia: neurovascular and autonomic mechanisms
    VA IK-2 CX-002457Apr 1, 2023 - Mar 31, 2028
    Role: PI
    Description: This project examines the hypothesis that the coupling between neural and vascular signals in the brain exhibit a stress-like pattern in schizophrenia. By simultaneously measuring cardiovascular physiology, neural activity from electroencephalography (EEG) and vascular dynamics from functional magnetic resonance imaging (fMRI), this study aims to derive novel biomarkers of heart-brain communication in schizophrenia.
    Neurometabolic mechanisms of aberrant resting brain activity in schizophrenia
    NIH IK1CX002089Apr 1, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Description: This project examines the hypothesis that cerebral metabolic abnormalities underlie the neural deficits that contribute to psychiatric symptoms in schizophrenia. By simultaneously measuring neural activity from electroencephalography (EEG) and metabolic activity from functional magnetic resonance imaging (fMRI) this study aims to derive novel biomarkers of neurometabolic coupling in schizophrenia.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Languaging psychopathology: neurobiology and metaphor. Front Psychiatry. 2024; 15:1320771. Syed A, Jacob MS. PMID: 38374980; PMCID: PMC10875027.
      View in: PubMed   Mentions:
    2. The Scanner as the Stimulus: Deficient Gamma-BOLD Coupling in Schizophrenia at Rest. Schizophr Bull. 2023 09 07; 49(5):1364-1374. Jacob MS, Sargent K, Roach BJ, Shamshiri EA, Mathalon DH, Ford JM. PMID: 37098100; PMCID: PMC10483456.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Toward a Bio-Organon: A model of interdependence between energy, information and knowledge in living systems. Biosystems. 2023 Aug; 230:104939. Jacob MS. PMID: 37295595.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Cognition is entangled with metabolism: relevance for resting-state EEG-fMRI. Front Hum Neurosci. 2023; 17:976036. Jacob M, Ford J, Deacon T. PMID: 37113322; PMCID: PMC10126302.
      View in: PubMed   Mentions:
    5. Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study. Neuroimage. 2021 12 15; 245:118705. Jacob MS, Roach BJ, Sargent KS, Mathalon DH, Ford JM. PMID: 34798229.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    6. Development and Implementation of a Chief Resident for Research Role in a Psychiatry Residency Training Program. Adv Med Educ Pract. 2021; 12:1231-1236. Hwong AR, Morgan S, Young CA, Besterman AD, Jacob M, Williams J, Reus VI, Mathews CA, Hung E, Voglmaier S. PMID: 34720606; PMCID: PMC8549966.
      View in: PubMed   Mentions:
    7. Visual cortical plasticity and the risk for psychosis: An interim analysis of the North American Prodrome Longitudinal Study. Schizophr Res. 2021 04; 230:26-37. Jacob MS, Roach BJ, Hamilton HK, Carrión RE, Belger A, Duncan E, Johannesen J, Keshavan M, Loo S, Niznikiewicz M, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, McGlashan TH, Perkins DO, Stone W, Tsuang M, Walker EF, Woods SW, Mathalon DH. PMID: 33667856; PMCID: PMC8328744.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Aberrant activity in conceptual networks underlies N400 deficits and unusual thoughts in schizophrenia. Neuroimage Clin. 2019; 24:101960. Jacob MS, Ford JM, Roach BJ, Calhoun VD, Mathalon DH. PMID: 31398555; PMCID: PMC6699247.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Steering Transforms the Cortical Representation of Self-Movement from Direction to Destination. J Neurosci. 2015 Dec 09; 35(49):16055-63. Jacob MS, Duffy CJ. PMID: 26658859; PMCID: PMC4682777.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    10. A culinary laboratory for nutrition education. Clin Teach. 2016 Jun; 13(3):197-201. Jacob M, Stewart P, Medina-Walpole A, Fong CT. PMID: 26109349.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. Might cortical hyper-responsiveness in aging contribute to Alzheimer's disease? PLoS One. 2014; 9(9):e105962. Jacob MS, Duffy CJ. PMID: 25208332; PMCID: PMC4160186.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine. Med Hypotheses. 2005; 64(5):930-7. Jacob MS, Presti DE. PMID: 15780487.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
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