Michael Mann, MD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Address500 Parnassus Avenue
San Francisco CA 94117
Phone415-353-7502
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency2003Cardiothoracic Surgery
    Harvard Medical School/Brigham and Women's HospitalResidency2001General Surgery
    Stanford UniversityM.D.1991School of Medicine
    Princeton UniversityAB1985Chemistry

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    The role of S1P signaling in surgical cardiac remodeling
    NIH K08HL079239Apr 1, 2006 - Mar 31, 2012
    Role: Principal Investigator
    ERK Signaling and a Hybrid Surgical/Molecular Approach for Chronic Heart Failure
    NIH R01HL083118Dec 1, 2005 - Apr 30, 2017
    Role: Principal Investigator
    GROWTH FACTOR EXPRESSION IN VEIN GRAFT STENOSIS
    NIH F32HL008850Oct 28, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetic and immunologic features of recurrent stage I lung adenocarcinoma. Sci Rep. 2021 12 08; 11(1):23690. Kratz JR, Li JZ, Tsui J, Lee JC, Ding VW, Rao AA, Mann MJ, Chan V, Combes AJ, Krummel MF, Jablons DM. PMID: 34880292; PMCID: PMC8654957.
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    2. Improved outcomes and staging in non-small-cell lung cancer guided by a molecular assay. Future Oncol. 2021 Dec; 17(34):4785-4795. Gupta AR, Woodard GA, Jablons DM, Mann MJ, Kratz JR. PMID: 34435876.
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    3. Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early-Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit From Adjuvant Chemotherapy. Clin Lung Cancer. 2021 11; 22(6):587-595. Woodard GA, Kratz JR, Haro G, Gubens MA, Blakely CM, Jones KD, Mann MJ, Jablons DM. PMID: 34544620.
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    4. Resectability, Recurrence, and Risk Stratification of Giant Solitary Fibrous Tumors in the Thoracic Cavity. Ann Surg Oncol. 2021 Sep; 28(9):4953-4959. Woodard GA, Fels Elliott DR, Yap A, Haro GJ, Kratz JR, Mann MJ, Jones KD, Jablons DM. PMID: 33728541.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. MO01.13 Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit from Adjuvant Chemotherapy. Journal of Thoracic Oncology. 2021 Jan 1; 16(1):s21. Woodard WG, Kratz KJ, Haro HG, Gubens GM, Blakely BC, Jones JK, Mann MM, Jablons JD. .
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    6. Comparison of Conventional TNM and Novel TNMB Staging Systems for Non-Small Cell Lung Cancer. JAMA Netw Open. 2019 12 02; 2(12):e1917062. Haro GJ, Sheu B, Cook NR, Woodard GA, Mann MJ, Kratz JR. PMID: 31808928; PMCID: PMC6902768.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. MA06.09 Timing of Driver Mutation Development and the Genetic Evolution of Semi-Solid Lung Nodules into Early NSCLC. Journal of Thoracic Oncology. 2019 Oct 1; 14(10):s271-s272. Woodard WG, Ding DV, Kim KI, Jones JK, Chavez CG, Haro HG, Kratz KJ, Mann MM, Rotow RJ, Blakely BC, Jablons JD. .
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    8. Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma. Cancer Manag Res. 2019; 11:8209-8218. Jiang L, Tolani B, Yeh CC, Fan Y, Reza JA, Horvai AE, Xia E, Kratz JR, Jablons DM, Mann MJ. PMID: 31686913; PMCID: PMC6751227.
      View in: PubMed   Mentions: 1  
    9. Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging. J Thorac Oncol. 2019 07; 14(7):1223-1232. Kratz JR, Haro GJ, Cook NR, He J, Van Den Eeden SK, Woodard GA, Gubens MA, Jahan TM, Jones KD, Kim IJ, He B, Jablons DM, Mann MJ. PMID: 30959120.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    10. P2.16-12 Expanded Data Confirm Molecular Testing Identifies Lung Adenocarcinoma Patients, Including Stage IA, Who Benefit from Adjuvant Chemotherapy. Journal of Thoracic Oncology. 2018 Oct 1; 13(10):s835. Woodard WG, Wang WS, Kratz KJ, Haro HG, Gubens GM, Blakely BC, Jahan JT, Jones JK, Mann MM, Jablons JD. .
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    11. Propensity Matched Analysis of Perioperative Outcomes in Robotic-Assisted Thoracic Surgery, Video Assisted Thoracic Surgery, and Open Lung Resections. Journal of the American College of Surgeons. 2018 Oct 1; 227(4):s53. Haro HG, Kratz KJ, Jablons JD, Mann MM, Kukreja KJ. .
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    12. P3.03-24 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging. Journal of Thoracic Oncology. 2018 Oct 1; 13(10):s919. Haro HG, Kratz KJ, Cook CN, He HJ, Van Den Eeden VS, Woodard WG, Gubens GM, Jahan JT, Jones JK, Kim KI, He HB, Jablons JD, Mann MM. .
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    13. A review of soft-tissue sarcomas: translation of biological advances into treatment measures. Cancer Manag Res. 2018; 10:1089-1114. Hoang NT, Acevedo LA, Mann MJ, Tolani B. PMID: 29785138; PMCID: PMC5955018.
      View in: PubMed   Mentions: 22  
    14. Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice. PLoS One. 2017; 12(12):e0188471. Yeh CC, Fan Y, Xu Y, Yang YL, Simpson PC, Mann MJ. PMID: 29216197; PMCID: PMC5720786.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect. J Biomed Sci. 2017 Nov 24; 24(1):89. Yeh CC, Fan Y, Yang YL, Mann MJ. PMID: 29178881; PMCID: PMC5702213.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2018 01; 19(1):58-64. Woodard GA, Wang SX, Kratz JR, Zoon-Besselink CT, Chiang CY, Gubens MA, Jahan TM, Blakely CM, Jones KD, Mann MJ, Jablons DM. PMID: 28645632.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    17. OA19.06 Adjuvant Chemotherapy Decisions Based on Molecular Risk Status Improves Outcomes in Early Stage, Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 2017 Jan 1; 12(1):s320. Woodard WG, Crockard CJ, Zoon-Besselink ZC, Kratz KJ, Gubens GM, Jahan JT, Blakely BC, Jones JK, Mann MM, Jablons JD. .
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    18. P1.03-066 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer TNM Staging Topic: Staging. Journal of Thoracic Oncology. 2017 Jan 1; 12(1):s584-s585. Kratz KJ, Cook CN, Woodard WG, Jones JK, Gubens GM, Jahan JT, Kim KI, He HB, Jablons JD, Mann MM. .
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    19. Spacial and Temporal Patterns of Gene Expression After Cardiac MEK1 Gene Transfer Improve Post-Infarction Remodeling Without Inducing Global Hypertrophy. J Cell Biochem. 2017 04; 118(4):775-784. Fan Y, Yang YL, Yeh CC, Mann MJ. PMID: 27639174.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms. Anticancer Res. 2015 Jun; 35(6):3167-73. Yeh CC, Fan Y, Jiang L, Yang YL, He B, You L, Mann M. PMID: 26026076.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    21. Prognostic molecular assay might improve identification of patients at risk for recurrence in early-stage non-small-cell lung cancer. Clin Lung Cancer. 2014 Nov; 15(6):426-32. Woodard GA, Gubens MA, Jahan TM, Jones KD, Kukreja J, Theodore PR, Cardozo S, Jew G, Clary-Macy C, Jablons DM, Mann MJ. PMID: 25258195.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma. J Thorac Cardiovasc Surg. 2014 Apr; 147(4):1193-200; discussion 1200-1. Reza J, Sammann A, Jin C, Horvai A, Hudnall M, Jablons DM, Jahan T, Kornak J, Mann MJ. PMID: 24507991.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. VATS lobectomy facilitates the delivery of adjuvant docetaxel-carboplatin chemotherapy in patients with non-small cell lung cancer. J Thorac Dis. 2013 Oct; 5(5):578-84. Zhi X, Gao W, Han B, Yang Y, Li H, Liu D, Wang C, Min G, Long H, Rigas JR, Carey M, Jahan T, Sammann A, Reza J, Wang D, Mann MJ, Jablons DM, He J, China Clinical Trials Consortium. PMID: 24255769; PMCID: PMC3815738.
      View in: PubMed   Mentions: 2  
    24. Novel video-assisted thoracoscopic surgery metastatectomy technique equivalent to open thoracotomy for identification of numerous and small lesions. Journal of the American College of Surgeons. 2013 Sep 1; 217(3):s43. Reza RJ, Hudnall HM, Sammann SA, Jablons JD, Mann MM. .
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    25. International trial of adjuvant therapy in high risk stage I non-squamous cell carcinoma identified by a 14-gene prognostic signature. Transl Lung Cancer Res. 2013 Jun; 2(3):222-5. Kratz JR, Mann MJ, Jablons DM. PMID: 25806235; PMCID: PMC4367604.
      View in: PubMed   Mentions: 4  
    26. Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer. Diagn Mol Pathol. 2013 Jun; 22(2):65-9. Kratz JR, Tham PT, Mulvihill MS, Ziaei F, Ray MR, Hurst JW, Segal MR, Berryman DM, Chu W, He B, Jablons DM, Mann MJ. PMID: 23628816.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    27. Impact of a multigene prognostic assay on postoperative management of early-stage non-small cell lung cancer. Journal of Clinical Oncology. 2013 May 20; 31(15_suppl):e22124-e22124. Dormady DS, Jahan JT, Mann MM, Jablons JD, Broder BM, DeCristofaro DA, Anene AA. .
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    28. Prognostic assay in small, node-negative non-small cell lung cancer--reply. JAMA. 2013 Feb 27; 309(8):769-70. Mann MJ, Jablons DM, Kratz JR. PMID: 23443437.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. MEK1-induced physiological hypertrophy inhibits chronic post-myocardial infarction remodeling in mice. J Cell Biochem. 2013 Jan; 114(1):47-55. Yeh CC, Malhotra D, Yang YL, Xu Y, Fan Y, Li H, Mann MJ. PMID: 22821618.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    30. A prognostic assay to identify patients at high risk of mortality despite small, node-negative lung tumors. JAMA. 2012 Oct 24; 308(16):1629-31. Kratz JR, Van den Eeden SK, He J, Jablons DM, Mann MJ. PMID: 23093159.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    31. Pulmonary metastasectomy: Improving survival with less invasive, more aggressive surgery. Journal of the American College of Surgeons. 2012 Sep 1; 215(3):s46. Reza RJ, Sammann SA, Grimes GB, Mann MM. .
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    32. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet. 2012 Mar 03; 379(9818):823-32. Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, Mulvihill MS, Ziaei F, Zhang H, Su B, Zhi X, Quesenberry CP, Habel LA, Deng Q, Wang Z, Zhou J, Li H, Huang MC, Yeh CC, Segal MR, Ray MR, Jones KD, Raz DJ, Xu Z, Jahan TM, Berryman D, He B, Mann MJ, Jablons DM. PMID: 22285053; PMCID: PMC3294002.
      View in: PubMed   Mentions: 136     Fields:    Translation:Humans
    33. IL11 is prognostic of survival in lung adenocarcinoma. Journal of the American College of Surgeons. 2011 Sep 1; 213(3):s38-s39. Kratz KJ, Pham PP, Mulvihill MM, Ray RM, Mann MM, Jablons JD. .
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    34. Stem Cell Transplantation to the Heart. . 2010 Oct 7; 279-297. Mann MM. .
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    35. Biomimetic matrices for myocardial stabilization and stem cell transplantation. J Biomed Mater Res A. 2010 Dec 15; 95(4):1055-66. Wall ST, Yeh CC, Tu RY, Mann MJ, Healy KE. PMID: 20878934; PMCID: PMC2975774.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    36. Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. J Cell Biochem. 2010 Apr 15; 109(6):1185-91. Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ. PMID: 20186881; PMCID: PMC3397305.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    37. Heart Failure Switches RV Inotropic Responses from Negative to Positive. Biophysical Journal. 2010 Jan 1; 98(3):715a. Wang WG, Yeh YC, Jensen JB, Mann MM, Simpson SP, Baker BA. .
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    38. Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H913-20. Wang GY, Yeh CC, Jensen BC, Mann MJ, Simpson PC, Baker AJ. PMID: 20035030; PMCID: PMC2838546.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    39. Myocardial survival signaling in response to stem cell transplantation. J Am Coll Surg. 2009 Apr; 208(4):607-13. Li H, Malhotra D, Yeh CC, Tu R, Zhu BQ, Birger N, Wisneski A, Cha J, Karliner JS, Mann MJ. PMID: 19476797; PMCID: PMC2817986.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    40. Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction. Am J Physiol Heart Circ Physiol. 2009 Apr; 296(4):H1193-9. Yeh CC, Li H, Malhotra D, Huang MC, Zhu BQ, Goetzl EJ, Vessey DA, Karliner JS, Mann MJ. PMID: 19234089; PMCID: PMC2670694.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    41. Surgical ventricular reconstruction in mice: elucidating potential targets for combined molecular/surgical intervention. J Thorac Cardiovasc Surg. 2009 Apr; 137(4):942-9. Yeh CC, Malhotra D, Li H, Nicholas S, Tu R, Mann MJ. PMID: 19327522; PMCID: PMC2692719.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    42. Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease. Cardiovasc Pathol. 2009 Sep-Oct; 18(5):253-61. Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH. PMID: 18835790; PMCID: PMC3367668.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    43. National Institutes of Health funding for cardiothoracic surgical research. J Thorac Cardiovasc Surg. 2008 Aug; 136(2):392-7; discussion 398-9. Ratcliffe MB, Howard C, Mann M, del Nido P. PMID: 18692647.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    44. National institutes of health funding for surgical research. Ann Surg. 2008 Feb; 247(2):217-21. Mann M, Tendulkar A, Birger N, Howard C, Ratcliffe MB. PMID: 18216525.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    45. Transcription factor decoys: a new model for disease intervention. Ann N Y Acad Sci. 2005 Nov; 1058:128-39. Mann MJ. PMID: 16394132.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    46. Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia. J Heart Lung Transplant. 2005 Feb; 24(2):222-5. Mann MJ, Tseng E, Ratcliffe M, Strattman G, De Silva A, Demarco T, Achorn N, Moskalik W, Hoopes C. PMID: 15701441.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    47. Reversal of direct thrombin inhibition after cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia. Anesth Analg. 2004 Jun; 98(6):1635-1639. Stratmann G, deSilva AM, Tseng EE, Hambleton J, Balea M, Romo AJ, Mann MJ, Achorn NL, Moskalik WF, Hoopes CW. PMID: 15155316.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    48. Cell cycle-dependent regulation of smooth muscle cell activation. Arterioscler Thromb Vasc Biol. 2004 May; 24(5):845-50. Braun-Dullaeus RC, Mann MJ, Sedding DG, Sherwood SW, von der Leyen HE, Dzau VJ. PMID: 15016640.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    49. Isolated pulmonary arteriovenous malformations requiring anatomic resection. J Thorac Cardiovasc Surg. 2004 Feb; 127(2):574-6. Mann MJ, Kramer MJ, Hall TS, Anastassiou P, Katz J, Golden J, Jones K, Jablons DM. PMID: 14762372.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Novel strategies for the prevention of bypass graft failure. BioDrugs. 2004; 18(1):1-8. Mann MJ. PMID: 14733603.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    51. Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. Circulation. 2003 Nov 25; 108(21):2710-5. Griese DP, Ehsan A, Melo LG, Kong D, Zhang L, Mann MJ, Pratt RE, Mulligan RC, Dzau VJ. PMID: 14597586.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    52. Transcription factor decoys for the prevention of vein bypass graft failure. Am J Cardiovasc Drugs. 2003; 3(2):79-85. Mann MJ, Conte MS. PMID: 14727934.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    53. Molecular approaches for the treatment of atherosclerosis. Cardiol Clin. 2002 Nov; 20(4):633-43. Mann MJ, Dzau VJ. PMID: 12472049.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Genetic interventions for vein bypass graft disease: a review. J Vasc Surg. 2002 Nov; 36(5):1040-52. Conte MS, Mann MJ, Simosa HF, Rhynhart KK, Mulligan RC. PMID: 12422116.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    55. Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. Circulation. 2002 Apr 09; 105(14):1686-92. Ehsan A, Mann MJ, Dell'Acqua G, Tamura K, Braun-Dullaeus R, Dzau VJ. PMID: 11940548.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    56. Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation. 2002 Feb 05; 105(5):602-7. Melo LG, Agrawal R, Zhang L, Rezvani M, Mangi AA, Ehsan A, Griese DP, Dell'Acqua G, Mann MJ, Oyama J, Yet SF, Layne MD, Perrella MA, Dzau VJ. PMID: 11827926.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
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