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Michael Mann, MD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Phone415-353-7502
EmailMichael.Mann@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency2003Cardiothoracic Surgery
    Harvard Medical School/Brigham and Women's HospitalResidency2001General Surgery
    Stanford UniversityM.D.1991School of Medicine
    Princeton UniversityAB1985Chemistry

    Collapse Research 
    Collapse Research Activities and Funding
    The role of S1P signaling in surgical cardiac remodeling
    NIH/NHLBI K08HL079239Apr 1, 2006 - Mar 31, 2012
    Role: Principal Investigator
    ERK Signaling and a Hybrid Surgical/Molecular Approach for Chronic Heart Failure
    NIH/NHLBI R01HL083118Dec 1, 2005 - Apr 30, 2017
    Role: Principal Investigator
    GROWTH FACTOR EXPRESSION IN VEIN GRAFT STENOSIS
    NIH/NHLBI F32HL008850Oct 28, 1993
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kratz JR, Haro GJ, Cook NR, He J, Van Den Eeden SK, Woodard GA, Gubens MA, Jahan TM, Jones KD, Kim IJ, He B, Jablons DM, Mann MJ. Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging. J Thorac Oncol. 2019 Jul; 14(7):1223-1232. PMID: 30959120.
      View in: PubMed
    2. Hoang NT, Acevedo LA, Mann MJ, Tolani B. A review of soft-tissue sarcomas: translation of biological advances into treatment measures. Cancer Manag Res. 2018; 10:1089-1114. PMID: 29785138.
      View in: PubMed
    3. Yeh CC, Fan Y, Xu Y, Yang YL, Simpson PC, Mann MJ. Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice. PLoS One. 2017; 12(12):e0188471. PMID: 29216197.
      View in: PubMed
    4. Yeh CC, Fan Y, Yang YL, Mann MJ. Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect. J Biomed Sci. 2017 Nov 24; 24(1):89. PMID: 29178881.
      View in: PubMed
    5. Woodard GA, Wang SX, Kratz JR, Zoon-Besselink CT, Chiang CY, Gubens MA, Jahan TM, Blakely CM, Jones KD, Mann MJ, Jablons DM. Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2018 01; 19(1):58-64. PMID: 28645632.
      View in: PubMed
    6. Fan Y, Yang YL, Yeh CC, Mann MJ. Spacial and Temporal Patterns of Gene Expression After Cardiac MEK1 Gene Transfer Improve Post-Infarction Remodeling Without Inducing Global Hypertrophy. J Cell Biochem. 2017 04; 118(4):775-784. PMID: 27639174.
      View in: PubMed
    7. Yeh CC, Fan Y, Jiang L, Yang YL, He B, You L, Mann M. Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms. Anticancer Res. 2015 Jun; 35(6):3167-73. PMID: 26026076.
      View in: PubMed
    8. Woodard GA, Gubens MA, Jahan TM, Jones KD, Kukreja J, Theodore PR, Cardozo S, Jew G, Clary-Macy C, Jablons DM, Mann MJ. Prognostic molecular assay might improve identification of patients at risk for recurrence in early-stage non-small-cell lung cancer. Clin Lung Cancer. 2014 Nov; 15(6):426-32. PMID: 25258195.
      View in: PubMed
    9. Reza J, Sammann A, Jin C, Horvai A, Hudnall M, Jablons DM, Jahan T, Kornak J, Mann MJ. Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma. J Thorac Cardiovasc Surg. 2014 Apr; 147(4):1193-200; discussion 1200-1. PMID: 24507991.
      View in: PubMed
    10. Zhi X, Gao W, Han B, Yang Y, Li H, Liu D, Wang C, Min G, Long H, Rigas JR, Carey M, Jahan T, Sammann A, Reza J, Wang D, Mann MJ, Jablons DM, He J. VATS lobectomy facilitates the delivery of adjuvant docetaxel-carboplatin chemotherapy in patients with non-small cell lung cancer. J Thorac Dis. 2013 Oct; 5(5):578-84. PMID: 24255769.
      View in: PubMed
    11. Kratz JR, Mann MJ, Jablons DM. International trial of adjuvant therapy in high risk stage I non-squamous cell carcinoma identified by a 14-gene prognostic signature. Transl Lung Cancer Res. 2013 Jun; 2(3):222-5. PMID: 25806235.
      View in: PubMed
    12. Kratz JR, Tham PT, Mulvihill MS, Ziaei F, Ray MR, Hurst JW, Segal MR, Berryman DM, Chu W, He B, Jablons DM, Mann MJ. Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer. Diagn Mol Pathol. 2013 Jun; 22(2):65-9. PMID: 23628816.
      View in: PubMed
    13. Mann MJ, Jablons DM, Kratz JR. Prognostic assay in small, node-negative non-small cell lung cancer--reply. JAMA. 2013 Feb 27; 309(8):769-70. PMID: 23443437.
      View in: PubMed
    14. Yeh CC, Malhotra D, Yang YL, Xu Y, Fan Y, Li H, Mann MJ. MEK1-induced physiological hypertrophy inhibits chronic post-myocardial infarction remodeling in mice. J Cell Biochem. 2013 Jan; 114(1):47-55. PMID: 22821618.
      View in: PubMed
    15. Kratz JR, Van den Eeden SK, He J, Jablons DM, Mann MJ. A prognostic assay to identify patients at high risk of mortality despite small, node-negative lung tumors. JAMA. 2012 Oct 24; 308(16):1629-31. PMID: 23093159.
      View in: PubMed
    16. Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, Mulvihill MS, Ziaei F, Zhang H, Su B, Zhi X, Quesenberry CP, Habel LA, Deng Q, Wang Z, Zhou J, Li H, Huang MC, Yeh CC, Segal MR, Ray MR, Jones KD, Raz DJ, Xu Z, Jahan TM, Berryman D, He B, Mann MJ, Jablons DM. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet. 2012 Mar 03; 379(9818):823-32. PMID: 22285053.
      View in: PubMed
    17. Wall ST, Yeh CC, Tu RY, Mann MJ, Healy KE. Biomimetic matrices for myocardial stabilization and stem cell transplantation. J Biomed Mater Res A. 2010 Dec 15; 95(4):1055-66. PMID: 20878934.
      View in: PubMed
    18. Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ. Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. J Cell Biochem. 2010 Apr 15; 109(6):1185-91. PMID: 20186881.
      View in: PubMed
    19. Wang GY, Yeh CC, Jensen BC, Mann MJ, Simpson PC, Baker AJ. Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H913-20. PMID: 20035030.
      View in: PubMed
    20. Li H, Malhotra D, Yeh CC, Tu R, Zhu BQ, Birger N, Wisneski A, Cha J, Karliner JS, Mann MJ. Myocardial survival signaling in response to stem cell transplantation. J Am Coll Surg. 2009 Apr; 208(4):607-13. PMID: 19476797.
      View in: PubMed
    21. Yeh CC, Li H, Malhotra D, Huang MC, Zhu BQ, Goetzl EJ, Vessey DA, Karliner JS, Mann MJ. Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction. Am J Physiol Heart Circ Physiol. 2009 Apr; 296(4):H1193-9. PMID: 19234089.
      View in: PubMed
    22. Yeh CC, Malhotra D, Li H, Nicholas S, Tu R, Mann MJ. Surgical ventricular reconstruction in mice: elucidating potential targets for combined molecular/surgical intervention. J Thorac Cardiovasc Surg. 2009 Apr; 137(4):942-9. PMID: 19327522.
      View in: PubMed
    23. Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH. Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease. Cardiovasc Pathol. 2009 Sep-Oct; 18(5):253-61. PMID: 18835790.
      View in: PubMed
    24. Ratcliffe MB, Howard C, Mann M, del Nido P. National Institutes of Health funding for cardiothoracic surgical research. J Thorac Cardiovasc Surg. 2008 Aug; 136(2):392-7; discussion 398-9. PMID: 18692647.
      View in: PubMed
    25. Mann M, Tendulkar A, Birger N, Howard C, Ratcliffe MB. National institutes of health funding for surgical research. Ann Surg. 2008 Feb; 247(2):217-21. PMID: 18216525.
      View in: PubMed
    26. Mann MJ. Transcription factor decoys: a new model for disease intervention. Ann N Y Acad Sci. 2005 Nov; 1058:128-39. PMID: 16394132.
      View in: PubMed
    27. Mann MJ, Tseng E, Ratcliffe M, Strattman G, De Silva A, Demarco T, Achorn N, Moskalik W, Hoopes C. Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia. J Heart Lung Transplant. 2005 Feb; 24(2):222-5. PMID: 15701441.
      View in: PubMed
    28. Stratmann G, deSilva AM, Tseng EE, Hambleton J, Balea M, Romo AJ, Mann MJ, Achorn NL, Moskalik WF, Hoopes CW. Reversal of direct thrombin inhibition after cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia. Anesth Analg. 2004 Jun; 98(6):1635-9, table of contents. PMID: 15155316.
      View in: PubMed
    29. Braun-Dullaeus RC, Mann MJ, Sedding DG, Sherwood SW, von der Leyen HE, Dzau VJ. Cell cycle-dependent regulation of smooth muscle cell activation. Arterioscler Thromb Vasc Biol. 2004 May; 24(5):845-50. PMID: 15016640.
      View in: PubMed
    30. Mann MJ, Kramer MJ, Hall TS, Anastassiou P, Katz J, Golden J, Jones K, Jablons DM. Isolated pulmonary arteriovenous malformations requiring anatomic resection. J Thorac Cardiovasc Surg. 2004 Feb; 127(2):574-6. PMID: 14762372.
      View in: PubMed
    31. Mann MJ. Novel strategies for the prevention of bypass graft failure. BioDrugs. 2004; 18(1):1-8. PMID: 14733603.
      View in: PubMed
    32. Griese DP, Ehsan A, Melo LG, Kong D, Zhang L, Mann MJ, Pratt RE, Mulligan RC, Dzau VJ. Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. Circulation. 2003 Nov 25; 108(21):2710-5. PMID: 14597586.
      View in: PubMed
    33. Mann MJ, Conte MS. Transcription factor decoys for the prevention of vein bypass graft failure. Am J Cardiovasc Drugs. 2003; 3(2):79-85. PMID: 14727934.
      View in: PubMed
    34. Mann MJ, Dzau VJ. Molecular approaches for the treatment of atherosclerosis. Cardiol Clin. 2002 Nov; 20(4):633-43. PMID: 12472049.
      View in: PubMed
    35. Conte MS, Mann MJ, Simosa HF, Rhynhart KK, Mulligan RC. Genetic interventions for vein bypass graft disease: a review. J Vasc Surg. 2002 Nov; 36(5):1040-52. PMID: 12422116.
      View in: PubMed
    36. Ehsan A, Mann MJ, Dell'Acqua G, Tamura K, Braun-Dullaeus R, Dzau VJ. Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. Circulation. 2002 Apr 09; 105(14):1686-92. PMID: 11940548.
      View in: PubMed
    37. Melo LG, Agrawal R, Zhang L, Rezvani M, Mangi AA, Ehsan A, Griese DP, Dell'Acqua G, Mann MJ, Oyama J, Yet SF, Layne MD, Perrella MA, Dzau VJ. Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation. 2002 Feb 05; 105(5):602-7. PMID: 11827926.
      View in: PubMed
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