Michael Pickup, PhD

TitlePostdoctoral Scholar Employee
SchoolUCSF School of Medicine
Address513 Parnassus Avenue
San Francisco CA 94117
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Elloumi-Hannachi I, Gooch K, Sarang-Sieminski AL, García AJ, Weaver VM. a5ß1-integrinpromotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. Mol Biol Cell. 2017 Sep 06. PMID: 28877984.
      View in: PubMed
    2. Pickup M, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV. Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells. Cancer Immunol Res. 2017 Sep; 5(9):718-729. PMID: 28775207.
      View in: PubMed
    3. Pickup M, Owens P, Moses HL. TGF-ß, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment. Cold Spring Harb Perspect Biol. 2017 May 01; 9(5). PMID: 28062564.
      View in: PubMed
    4. Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup M, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell. 2017 Jun 01; 28(11):1467-1488. PMID: 28381423.
      View in: PubMed
    5. Kaushik S, Pickup M, Weaver VM. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer. Cancer Metastasis Rev. 2016 Dec; 35(4):655-667. PMID: 27914000.
      View in: PubMed
    6. Miroshnikova YA, Mouw JK, Barnes JM, Pickup M, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Dec; 18(12):1336-1345. PMID: 27820599.
      View in: PubMed
    7. Jovanovic B, Pickup M, Chytil A, Gorska AE, Johnson KC, Moses HL, Owens P. TßRIII Expression in Human Breast Cancer Stroma and the Role of Soluble TßRIII in Breast Cancer Associated Fibroblasts. Cancers (Basel). 2016 Nov 04; 8(11). PMID: 27827906.
      View in: PubMed
    8. Laklai H, Miroshnikova YA, Pickup M, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 May; 22(5):497-505. PMID: 27089513; PMCID: PMC4860133 [Available on 10/18/16].
    9. Pickup M, Hover LD, Guo Y, Gorska AE, Chytil A, Novitskiy SV, Moses HL, Owens P. Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis. Oncotarget. 2015 Sep 08; 6(26):22890-904. PMID: 26274893; PMCID: PMC4673207.
    10. Yi Y, Polosukhina D, Love HD, Hembd A, Pickup M, Moses HL, Lovvorn HN, Zent R, Clark PE. A Murine Model of K-RAS and ß-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor. J Urol. 2015 Dec; 194(6):1762-70. PMID: 25934441; PMCID: PMC4782590.
    11. Shaw AK, Pickup M, Chytil A, Aakre M, Owens P, Moses HL, Novitskiy SV. TGFß signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS One. 2015; 10(1):e0117908. PMID: 25629162; PMCID: PMC4309578.
    12. Bates AL, Pickup M, Hallett MA, Dozier EA, Thomas S, Fingleton B. Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases. J Pathol. 2015 Apr; 235(5):773-83. PMID: 25469981; PMCID: PMC4357558.
    13. Pickup M, Mouw JK, Weaver VM. The extracellular matrix modulates the hallmarks of cancer. EMBO Rep. 2014 Dec; 15(12):1243-53. PMID: 25381661; PMCID: PMC4264927.
    14. Novitskiy SV, Forrester E, Pickup M, Gorska AE, Chytil A, Aakre M, Polosukhina D, Owens P, Yusupova DR, Zhao Z, Ye F, Shyr Y, Moses HL. Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis. Breast Cancer Res. 2014 Oct 04; 16(5):425. PMID: 25280532; PMCID: PMC4303109.
    15. Pickup M, Hover LD, Polikowsky ER, Chytil A, Gorska AE, Novitskiy SV, Moses HL, Owens P. BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation. Mol Oncol. 2015 Jan; 9(1):179-91. PMID: 25205038; PMCID: PMC4277920.
    16. Ryzhov SV, Pickup M, Chytil A, Gorska AE, Zhang Q, Owens P, Feoktistov I, Moses HL, Novitskiy SV. Role of TGF-ß signaling in generation of CD39+CD73+ myeloid cells in tumors. J Immunol. 2014 Sep 15; 193(6):3155-64. PMID: 25127858; PMCID: PMC4157098.
    17. Jovanovic B, Beeler JS, Pickup M, Chytil A, Gorska AE, Ashby WJ, Lehmann BD, Zijlstra A, Pietenpol JA, Moses HL. Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer. Breast Cancer Res. 2014 Jul 01; 16(4):R69. PMID: 24985072; PMCID: PMC4095685.
    18. Hansen AG, Arnold SA, Jiang M, Palmer TD, Ketova T, Merkel A, Pickup M, Samaras S, Shyr Y, Moses HL, Hayward SW, Sterling JA, Zijlstra A. ALCAM/CD166 is a TGF-ß-responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Res. 2014 Mar 01; 74(5):1404-15. PMID: 24385212; PMCID: PMC4149913.
    19. Pickup M, Novitskiy S, Moses HL. The roles of TGFß in the tumour microenvironment. Nat Rev Cancer. 2013 Nov; 13(11):788-99. PMID: 24132110; PMCID: PMC4025940.
    20. Pickup M, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-ß-deficient mouse mammary carcinomas. Cancer Res. 2013 Sep 01; 73(17):5336-46. PMID: 23856251; PMCID: PMC3766496.
    21. Owens P, Polikowsky H, Pickup M, Gorska AE, Jovanovic B, Shaw AK, Novitskiy SV, Hong CC, Moses HL. Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. PLoS One. 2013; 8(6):e67533. PMID: 23840733; PMCID: PMC3695869.
    22. Matise LA, Palmer TD, Ashby WJ, Nashabi A, Chytil A, Aakre M, Pickup M, Gorska AE, Zijlstra A, Moses HL. Lack of transforming growth factor-ß signaling promotes collective cancer cell invasion through tumor-stromal crosstalk. Breast Cancer Res. 2012 Jul 02; 14(4):R98. PMID: 22748014; PMCID: PMC3680921.
    23. Novitskiy SV, Pickup M, Chytil A, Polosukhina D, Owens P, Moses HL. Deletion of TGF-ß signaling in myeloid cells enhances their anti-tumorigenic properties. J Leukoc Biol. 2012 Sep; 92(3):641-51. PMID: 22685318; PMCID: PMC3427612.
    24. Novitskiy SV, Pickup M, Gorska AE, Owens P, Chytil A, Aakre M, Wu H, Shyr Y, Moses HL. TGF-ß receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms. Cancer Discov. 2011 Oct; 1(5):430-41. PMID: 22408746; PMCID: PMC3297196.
    25. Owens P, Pickup M, Novitskiy SV, Chytil A, Gorska AE, Aakre ME, West J, Moses HL. Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2814-9. PMID: 21576484; PMCID: PMC3286911.
    26. Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, Geng Y, Gray JW, Moses HL, Yang L. Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res. 2010 Aug 01; 70(15):6139-49. PMID: 20631080; PMCID: PMC4675145.
    27. Matise LA, Pickup M, Moses HL. TGF-beta helps cells fly solo. Nat Cell Biol. 2009 Nov; 11(11):1281-4. PMID: 19838176.
      View in: PubMed
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