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Michaela West, MD, PhD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentSurgery
Address1001 Potrero Ave, SFGH 1
San Francisco CA 94110
Phone415-206-4627
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    Collapse Research 
    Collapse Research Activities and Funding
    Inflammation and the Host Responses to Injury
    NIH U54GM062119Sep 1, 2000 - Aug 31, 2013
    Role: Co-Investigator
    Regulation of Macrophage Function in Surgical Sepsis
    NIH R01GM044764Aug 1, 1990 - Jul 31, 2010
    Role: Principal Investigator
    REGULATION OF MACROPHAGE FUNCTION IN SURGICAL SEPSIS
    NIH R29GM044764Aug 1, 1990 - Jul 31, 1995
    Role: Principal Investigator
    IMMUNOMODULATORY AGENTS IN THE TREATMENT OF PERITONITIS
    NIH F32AM007182Jul 1, 1985
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rattan R, Allen CJ, Sawyer RG, Mazuski J, Duane TM, Askari R, Banton KL, Claridge JA, Coimbra R, Cuschieri J, Dellinger EP, Evans HL, Guidry CA, Miller PR, O'Neill PJ, Rotstein OD, West M, Popovsky K, Namias N. Patients with Risk Factors for Complications Do Not Require Longer Antimicrobial Therapy for Complicated Intra-Abdominal Infection. Am Surg. 2016 Sep; 82(9):860-6. PMID: 27670577.
      View in: PubMed
    2. Sawyer RG, Claridge JA, Nathens AB, Rotstein OD, Duane TM, Evans HL, Cook CH, O'Neill PJ, Mazuski JE, Askari R, Wilson MA, Napolitano LM, Namias N, Miller PR, Dellinger EP, Watson CM, Coimbra R, Dent DL, Lowry SF, Cocanour CS, West M, Banton KL, Cheadle WG, Lipsett PA, Guidry CA, Popovsky K. Trial of short-course antimicrobial therapy for intraabdominal infection. N Engl J Med. 2015 May 21; 372(21):1996-2005. PMID: 25992746; PMCID: PMC4469182.
    3. Brown JB, Cohen MJ, Minei JP, Maier RV, West M, Billiar TR, Peitzman AB, Moore EE, Cuschieri J, Sperry JL. Pretrauma center red blood cell transfusion is associated with reduced mortality and coagulopathy in severely injured patients with blunt trauma. Ann Surg. 2015 May; 261(5):997-1005. PMID: 24670858; PMCID: PMC4176550.
    4. West M. Remote inflammatory and metabolic impact of acute injury. Crit Care Med. 2014 Jun; 42(6):1539-40. PMID: 24836786.
      View in: PubMed
    5. West M. What's new in shock? May 2014. Shock. 2014 May; 41(5):369-72. PMID: 25133597.
      View in: PubMed
    6. Feliciano DV, Moore EE, West M, Moore FA, Davis JW, Cocanour CS, Scalea TM, McIntyre RC. Western Trauma Association critical decisions in trauma: evaluation and management of peripheral vascular injury, part II. J Trauma Acute Care Surg. 2013 Sep; 75(3):391-7. PMID: 23928739.
      View in: PubMed
    7. Brown JB, Cohen MJ, Minei JP, Maier RV, West M, Billiar TR, Peitzman AB, Moore EE, Cuschieri J, Sperry JL. Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis. J Trauma Acute Care Surg. 2013 May; 74(5):1207-12; discussion 1212-4. PMID: 23609269; PMCID: PMC3634596.
    8. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West M, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3507-12. PMID: 23401516; PMCID: PMC3587220.
    9. Brown JB, Cohen MJ, Minei JP, Maier RV, West M, Billiar TR, Peitzman AB, Moore EE, Cuschieri J, Sperry JL. Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix. J Trauma Acute Care Surg. 2012 Dec; 73(6):1395-400. PMID: 23064602; PMCID: PMC3540988.
    10. Brown JB, Cohen MJ, Minei JP, Maier RV, West M, Billiar TR, Peitzman AB, Moore EE, Cushieri J, Sperry JL. Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion. J Trauma Acute Care Surg. 2012 Aug; 73(2):358-64; discussion 364. PMID: 22846940.
      View in: PubMed
    11. Cuschieri J, Johnson JL, Sperry J, West M, Moore EE, Minei JP, Bankey PE, Nathens AB, Cuenca AG, Efron PA, Hennessy L, Xiao W, Mindrinos MN, McDonald-Smith GP, Mason PH, Billiar TR, Schoenfeld DA, Warren HS, Cobb JP, Moldawer LL, Davis RW, Maier RV, Tompkins RG. Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg. 2012 May; 255(5):993-9. PMID: 22470077; PMCID: PMC3327791.
    12. Minei JP, Cuschieri J, Sperry J, Moore EE, West M, Harbrecht BG, O'Keefe GE, Cohen MJ, Moldawer LL, Tompkins RG, Maier RV. The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock. Crit Care Med. 2012 Apr; 40(4):1129-35. PMID: 22020243; PMCID: PMC3343366.
    13. West M. Trauma. Curr Opin Crit Care. 2011 Dec; 17(6):594-5. PMID: 22027407.
      View in: PubMed
    14. Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West M, Brownstein BH, Mason PH, Baker HV, Finnerty CC, Jeschke MG, López MC, Klein MB, Gamelli RL, Gibran NS, Arnoldo B, Xu W, Zhang Y, Calvano SE, McDonald-Smith GP, Schoenfeld DA, Storey JD, Cobb JP, Warren HS, Moldawer LL, Herndon DN, Lowry SF, Maier RV, Davis RW, Tompkins RG. A genomic storm in critically injured humans. J Exp Med. 2011 Dec 19; 208(13):2581-90. PMID: 22110166; PMCID: PMC3244029.
    15. Desai KH, Tan CS, Leek JT, Maier RV, Tompkins RG, Storey JD. Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study. PLoS Med. 2011 Sep; 8(9):e1001093. PMID: 21931541; PMCID: PMC3172280.
    16. Brakenridge SC, Phelan HA, Henley SS, Golden RM, Kashner TM, Eastman AE, Sperry JL, Harbrecht BG, Moore EE, Cuschieri J, Maier RV, Minei JP. Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injury. J Trauma. 2011 Aug; 71(2):299-305. PMID: 21825930; PMCID: PMC3716363.
    17. Kozar RA, Feliciano DV, Moore EE, Moore FA, Cocanour CS, West M, Davis JW, McIntyre RC. Western Trauma Association/critical decisions in trauma: operative management of adult blunt hepatic trauma. J Trauma. 2011 Jul; 71(1):1-5. PMID: 21818009.
      View in: PubMed
    18. Feliciano DV, Moore FA, Moore EE, West M, Davis JW, Cocanour CS, Kozar RA, McIntyre RC. Evaluation and management of peripheral vascular injury. Part 1. Western Trauma Association/critical decisions in trauma. J Trauma. 2011 Jun; 70(6):1551-6. PMID: 21817992.
      View in: PubMed
    19. Cohen MJ, West M. Acute traumatic coagulopathy: from endogenous acute coagulopathy to systemic acquired coagulopathy and back. J Trauma. 2011 May; 70(5 Suppl):S47-9. PMID: 21841573.
      View in: PubMed
    20. Xu W, Seok J, Mindrinos MN, Schweitzer AC, Jiang H, Wilhelmy J, Clark TA, Kapur K, Xing Y, Faham M, Storey JD, Moldawer LL, Maier RV, Tompkins RG, Wong WH, Davis RW, Xiao W. Human transcriptome array for high-throughput clinical studies. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3707-12. PMID: 21317363; PMCID: PMC3048146.
    21. Edmonds RD, Cuschieri J, Minei JP, Rosengart MR, Maier RV, Harbrecht BG, Billiar TR, Peitzman AB, Moore EE, Sperry JL. Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury. J Trauma. 2011 Feb; 70(2):292-8. PMID: 21307724.
      View in: PubMed
    22. Rajicic N, Cuschieri J, Finkelstein DM, Miller-Graziano CL, Hayden D, Moldawer LL, Moore E, O'Keefe G, Pelik K, Warren HS, Schoenfeld DA. Identification and interpretation of longitudinal gene expression changes in trauma. PLoS One. 2010 Dec 20; 5(12):e14380. PMID: 21187951; PMCID: PMC3004855.
    23. Richardson J, West M, Cuthbertson BH. Team working in intensive care: current evidence and future endeavors. Curr Opin Crit Care. 2010 Dec; 16(6):643-8. PMID: 20736827.
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    24. Cuschieri J, Bulger E, Schaeffer V, Sakr S, Nathens AB, Hennessy L, Minei J, Moore EE, O'Keefe G, Sperry J, Remick D, Tompkins R, Maier RV. Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure. Shock. 2010 Oct; 34(4):346-51. PMID: 20844410; PMCID: PMC3122160.
    25. Qian WJ, Petritis BO, Kaushal A, Finnerty CC, Jeschke MG, Monroe ME, Moore RJ, Schepmoes AA, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Herndon DN, Camp DG, Smith RD. Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics. J Proteome Res. 2010 Sep 03; 9(9):4779-89. PMID: 20698492; PMCID: PMC2945297.
    26. West M. Governors' Committee on Surgical Infections and Environmental Risks: an update. Bull Am Coll Surg. 2010 Sep; 95(9):27-8. PMID: 21449295.
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    27. Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, Warner EA, Moldawer LL, De A, Bankey PE, Petritis BO, Camp DG, Rosenbach AE, Goverman J, Fagan SP, Brownstein BH, Irimia D, Xu W, Wilhelmy J, Mindrinos MN, Smith RD, Davis RW, Tompkins RG, Toner M. Clinical microfluidics for neutrophil genomics and proteomics. Nat Med. 2010 Sep; 16(9):1042-7. PMID: 20802500; PMCID: PMC3136804.
    28. Cohen MJ, Carles M, Brohi K, Calfee CS, Rahn P, Call MS, Chesebro BB, West M, Pittet JF. Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans. J Trauma. 2010 Jun; 68(6):1273-8. PMID: 20539169; PMCID: PMC3531976.
    29. Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, Wong WH, Toner M, Warren HS, Schoenfeld DA, Rahme L, McDonald-Smith GP, Hayden D, Mason P, Fagan S, Yu YM, Cobb JP, Remick DG, Mannick JA, Lederer JA, Gamelli RL, Silver GM, West MA, Shapiro MB, Smith R, Camp DG, Qian W, Storey J, Mindrinos M, Tibshirani R, Lowry S, Calvano S, Chaudry I, West MA, Cohen M, Moore EE, Johnson J, Moldawer LL, Baker HV, Efron PA, Balis UG, Billiar TR, Ochoa JB, Sperry JL, Miller-Graziano CL, De AK, Bankey PE, Finnerty CC, Jeschke MG, Minei JP, Arnoldo BD, Hunt JL, Horton J, Cobb JP, Brownstein B, Freeman B, Maier RV, Nathens AB, Cuschieri J, Gibran N, Klein M, O'Keefe G. Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):9923-8. PMID: 20479259; PMCID: PMC2890487.
    30. Biffl WL, Cothren CC, Moore EE, Kozar R, Cocanour C, Davis JW, McIntyre RC, West M, Moore FA. Western Trauma Association critical decisions in trauma: screening for and treatment of blunt cerebrovascular injuries. J Trauma. 2009 Dec; 67(6):1150-3. PMID: 20009659.
      View in: PubMed
    31. Cobb JP, Moore EE, Hayden DL, Minei JP, Cuschieri J, Yang J, Li Q, Lin N, Brownstein BH, Hennessy L, Mason PH, Schierding WS, Dixon DJ, Tompkins RG, Warren HS, Schoenfeld DA, Maier RV. Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury. Ann Surg. 2009 Oct; 250(4):531-9. PMID: 19730236; PMCID: PMC3047595.
    32. Rajicic N, Finkelstein DM, Schoenfeld DA. Analysis of the relationship between longitudinal gene expressions and ordered categorical event data. Stat Med. 2009 Sep 30; 28(22):2817-32. PMID: 19618375; PMCID: PMC3774167.
    33. Neal MD, Cushieri J, Rosengart MR, Alarcon LH, Moore EE, Maier RV, Minei JP, Billiar TR, Peitzman AB, Sperry JL. Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis. J Trauma. 2009 Sep; 67(3):476-82; discussion 482-4. PMID: 19741387; PMCID: PMC4004067.
    34. Watson GA, Sperry JL, Rosengart MR, Minei JP, Harbrecht BG, Moore EE, Cuschieri J, Maier RV, Billiar TR, Peitzman AB. Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma. 2009 Aug; 67(2):221-7; discussion 228-30. PMID: 19667872.
      View in: PubMed
    35. Evans HL, Cuschieri J, Moore EE, Shapiro MB, Nathens AB, Johnson JL, Harbrecht BG, Minei JP, Bankey PE, Maier RV, West M. Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients. J Trauma. 2009 Aug; 67(2):384-8. PMID: 19667895; PMCID: PMC4001934.
    36. Hayden D, Lazar P, Schoenfeld D. Assessing statistical significance in microarray experiments using the distance between microarrays. PLoS One. 2009 Jun 16; 4(6):e5838. PMID: 19529777; PMCID: PMC2691999.
    37. Warren HS, Elson CM, Hayden DL, Schoenfeld DA, Cobb JP, Maier RV, Moldawer LL, Moore EE, Harbrecht BG, Pelak K, Cuschieri J, Herndon DN, Jeschke MG, Finnerty CC, Brownstein BH, Hennessy L, Mason PH, Tompkins RG. A genomic score prognostic of outcome in trauma patients. Mol Med. 2009 Jul-Aug; 15(7-8):220-7. PMID: 19593405; PMCID: PMC2707513.
    38. Crandall M, Shapiro MB, West M. Does splenectomy protect against immune-mediated complications in blunt trauma patients? Mol Med. 2009 Jul-Aug; 15(7-8):263-7. PMID: 19593410; PMCID: PMC2707521.
    39. Sperry JL, Frankel HL, Nathens AB, O'keefe GE, Cuschieri J, Moore EE, Maier RV, Minei JP. Characterization of persistent hyperglycemia: what does it mean postinjury? J Trauma. 2009 Apr; 66(4):1076-82. PMID: 19359917; PMCID: PMC4004069.
    40. Crandall M, Shapiro MB, Worley M, West M. Acute uncomplicated appendicitis: case time of day influences hospital length of stay. Surg Infect (Larchmt). 2009 Feb; 10(1):65-9. PMID: 19250008.
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    41. Qian WJ, Liu T, Petyuk VA, Gritsenko MA, Petritis BO, Polpitiya AD, Kaushal A, Xiao W, Finnerty CC, Jeschke MG, Jaitly N, Monroe ME, Moore RJ, Moldawer LL, Davis RW, Tompkins RG, Herndon DN, Camp DG, Smith RD. Large-scale multiplexed quantitative discovery proteomics enabled by the use of an (18)O-labeled "universal" reference sample. J Proteome Res. 2009 Jan; 8(1):290-9. PMID: 19053531; PMCID: PMC2752204.
    42. West M, Moore EE, Shapiro MB, Nathens AB, Cuschieri J, Johnson JL, Harbrecht BG, Minei JP, Bankey PE, Maier RV. Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients. J Trauma. 2008 Dec; 65(6):1511-9. PMID: 19077651; PMCID: PMC4004064.
    43. O'Keefe GE, Shelton M, Cuschieri J, Moore EE, Lowry SF, Harbrecht BG, Maier RV. Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VIII--Nutritional support of the trauma patient. J Trauma. 2008 Dec; 65(6):1520-8. PMID: 19077652; PMCID: PMC4004065.
    44. Moore FA, Davis JW, Moore EE, Cocanour CS, West M, McIntyre RC. Western Trauma Association (WTA) critical decisions in trauma: management of adult blunt splenic trauma. J Trauma. 2008 Nov; 65(5):1007-11. PMID: 19001966.
      View in: PubMed
    45. Davis JW, Moore FA, McIntyre RC, Cocanour CS, Moore EE, West M. Western trauma association critical decisions in trauma: management of pelvic fracture with hemodynamic instability. J Trauma. 2008 Nov; 65(5):1012-5. PMID: 19001967.
      View in: PubMed
    46. McIntyre RC, Moore FA, Davis JW, Cocanour CS, West M, Moore EE. Western trauma association critical decisions in trauma: foreword. J Trauma. 2008 Nov; 65(5):1005-6. PMID: 19001965.
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    47. Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, Rosengart MR, Maier RV, Billiar TR, Peitzman AB, Moore EE. An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma. 2008 Nov; 65(5):986-93. PMID: 19001962.
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    48. West M, Koons A. Endotoxin tolerance in sepsis: concentration-dependent augmentation or inhibition of LPS-stimulated macrophage TNF secretion by LPS pretreatment. J Trauma. 2008 Oct; 65(4):893-8; discussion 898-900. PMID: 18849808.
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    49. Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, Klein M, Silver G, Arnoldo B, Remick D, Tompkins RG. Temporal cytokine profiles in severely burned patients: a comparison of adults and children. Mol Med. 2008 Sep-Oct; 14(9-10):553-60. PMID: 18548133; PMCID: PMC2424320.
    50. An G, West M. Abdominal compartment syndrome: a concise clinical review. Crit Care Med. 2008 Apr; 36(4):1304-10. PMID: 18379259.
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    51. Koons A, Crandall M, An GC, Shapiro MB, Kramer S, West M. Even ephemeral endotoxin exposure establishes endotoxin tolerance. J Trauma. 2008 Apr; 64(4):938-42. PMID: 18404059.
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    52. Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, López MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner M. Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clin Chem. 2008 May; 54(5):891-900. PMID: 18375483; PMCID: PMC4011019.
    53. Sperry JL, Friese RS, Frankel HL, West M, Cuschieri J, Moore EE, Harbrecht BG, Peitzman AB, Billiar TR, Maier RV, Remick DG, Minei JP. Male gender is associated with excessive IL-6 expression following severe injury. J Trauma. 2008 Mar; 64(3):572-8; discussion 578-9. PMID: 18332795.
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    54. Sperry JL, Minei JP, Frankel HL, West M, Harbrecht BG, Moore EE, Maier RV, Nirula R. Early use of vasopressors after injury: caution before constriction. J Trauma. 2008 Jan; 64(1):9-14. PMID: 18188092.
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    55. Lederer JA, Brownstein BH, Lopez MC, Macmillan S, Delisle AJ, Macconmara MP, Choudhry MA, Xiao W, Lekousi S, Cobb JP, Baker HV, Mannick JA, Chaudry IH. Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiol Genomics. 2008 Feb 19; 32(3):299-310. PMID: 17986522.
      View in: PubMed
    56. Shapiro MB, West M, Nathens AB, Harbrecht BG, Moore FA, Bankey PE, Freeman B, Johnson JL, McKinley BA, Minei JP, Moore EE, Maier RV. V. Guidelines for sedation and analgesia during mechanical ventilation general overview. J Trauma. 2007 Oct; 63(4):945-50. PMID: 18090028.
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    57. Harbrecht BG, Minei JP, Shapiro MB, Nathens AB, Moore EE, West M, Bankey PE, Cuschieri J, Johnson JL, Maier RV. Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core-standard operating procedures for clinical care: VI. Blood glucose control in the critically ill trauma patient. J Trauma. 2007 Sep; 63(3):703-8. PMID: 18073622.
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    58. West M, Koons A, Crandall M, Skinner R, Worley M, Shapiro MB. Whole blood leukocyte mitogen activated protein kinases activation differentiates intensive care unit patients with systemic inflammatory response syndrome and sepsis. J Trauma. 2007 Apr; 62(4):805-11. PMID: 17426533.
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    59. Nathens AB, McMurray MK, Cuschieri J, Durr EA, Moore EE, Bankey PE, Freeman B, Harbrecht BG, Johnson JL, Minei JP, McKinley BA, Moore FA, Shapiro MB, West M, Tompkins RG, Maier RV. The practice of venous thromboembolism prophylaxis in the major trauma patient. J Trauma. 2007 Mar; 62(3):557-62; discussion 562-3. PMID: 17414328.
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    60. Silver GM, Klein MB, Herndon DN, Gamelli RL, Gibran NS, Altstein L, McDonald-Smith GP, Tompkins RG, Hunt JL. Standard operating procedures for the clinical management of patients enrolled in a prospective study of Inflammation and the Host Response to Thermal Injury. J Burn Care Res. 2007 Mar-Apr; 28(2):222-30. PMID: 17351437.
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    61. Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15564-9. PMID: 17032758; PMCID: PMC1592643.
    62. Rajicic N, Finkelstein DM, Schoenfeld DA. Survival analysis of longitudinal microarrays. Bioinformatics. 2006 Nov 01; 22(21):2643-9. PMID: 17032680.
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    63. Crandall M, West M. Evaluation of the abdomen in the critically ill patient: opening the black box. Curr Opin Crit Care. 2006 Aug; 12(4):333-9. PMID: 16810044.
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    64. West M, Shapiro MB, Nathens AB, Johnson JL, Moore EE, Minei JP, Bankey PE, Freeman B, Harbrecht BG, McKinley BA, Moore FA, Maier RV. Inflammation and the host response to injury, a large-scale collaborative project: Patient-oriented research core-standard operating procedures for clinical care. IV. Guidelines for transfusion in the trauma patient. J Trauma. 2006 Aug; 61(2):436-9. PMID: 16917462.
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    65. Sethu P, Moldawer LL, Mindrinos MN, Scumpia PO, Tannahill CL, Wilhelmy J, Efron PA, Brownstein BH, Tompkins RG, Toner M. Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Anal Chem. 2006 Aug 01; 78(15):5453-61. PMID: 16878882.
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    66. Klein MB, Silver G, Gamelli RL, Gibran NS, Herndon DN, Hunt JL, Tompkins RG. Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury. J Burn Care Res. 2006 Jul-Aug; 27(4):448-51. PMID: 16819346.
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    67. Liu T, Qian WJ, Gritsenko MA, Xiao W, Moldawer LL, Kaushal A, Monroe ME, Varnum SM, Moore RJ, Purvine SO, Maier RV, Davis RW, Tompkins RG, Camp DG, Smith RD. High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics. 2006 Oct; 5(10):1899-913. PMID: 16684767; PMCID: PMC1783978.
    68. Brownstein BH, Logvinenko T, Lederer JA, Cobb JP, Hubbard WJ, Chaudry IH, Remick DG, Baker HV, Xiao W, Mannick JA. Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiol Genomics. 2006 Feb 14; 24(3):298-309. PMID: 16478828.
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    69. De AK, Miller-Graziano CL, Calvano SE, Laudanski K, Lowry SF, Moldawer LL, Remick DG, Rajicic N, Schoenfeld D, Tompkins RG. Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation. J Immunol. 2005 Nov 01; 175(9):6155-62. PMID: 16237112.
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    70. Peterson BG, Matsumura JS, Morasch MD, West M, Eskandari MK. Percutaneous endovascular repair of blunt thoracic aortic transection. J Trauma. 2005 Nov; 59(5):1062-5. PMID: 16385279.
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    71. Chiu B, Ciaccio C, West M. Intestinal obstruction from furniture cushion foam bezoar. Surgery. 2005 Nov; 138(5):956-8. PMID: 16291400.
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    72. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF. A network-based analysis of systemic inflammation in humans. Nature. 2005 Oct 13; 437(7061):1032-7. PMID: 16136080.
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    73. Peterson B, Shapiro MB, Crandall M, Skinner R, West M. Trauma clip-art: early experience with an improved radiopaque marker system for delineating the path of penetrating injuries. J Trauma. 2005 May; 58(5):1078-81. PMID: 15920430.
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    74. Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O'keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13):4801-6. PMID: 15781863; PMCID: PMC555033.
    75. Qian WJ, Monroe ME, Liu T, Jacobs JM, Anderson GA, Shen Y, Moore RJ, Anderson DJ, Zhang R, Calvano SE, Lowry SF, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Camp DG, Smith RD. Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Mol Cell Proteomics. 2005 May; 4(5):700-9. PMID: 15753121; PMCID: PMC1829297.
    76. Copeland S, Warren HS, Lowry SF, Calvano SE, Remick D. Acute inflammatory response to endotoxin in mice and humans. Clin Diagn Lab Immunol. 2005 Jan; 12(1):60-7. PMID: 15642986; PMCID: PMC540200.
    77. Nathens AB, Curtis JR, Beale RJ, Cook DJ, Moreno RP, Romand JA, Skerrett SJ, Stapleton RD, Ware LB, Waldmann CS. Management of the critically ill patient with severe acute pancreatitis. Crit Care Med. 2004 Dec; 32(12):2524-36. PMID: 15599161.
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    78. Feezor RJ, Baker HV, Mindrinos M, Hayden D, Tannahill CL, Brownstein BH, Fay A, MacMillan S, Laramie J, Xiao W, Moldawer LL, Cobb JP, Laudanski K, Miller-Graziano CL, Maier RV, Schoenfeld D, Davis RW, Tompkins RG. Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics. 2004 Nov 17; 19(3):247-54. PMID: 15548831.
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    79. Finberg RW, Moellering RC, Tally FP, Craig WA, Pankey GA, Dellinger EP, West M, Joshi M, Linden PK, Rolston KV, Rotschafer JC, Rybak MJ. The importance of bactericidal drugs: future directions in infectious disease. Clin Infect Dis. 2004 Nov 01; 39(9):1314-20. PMID: 15494908.
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    80. Nathens AB, Curtis JR, Beale RJ, Cook DJ, Moreno RP, Romand JA, Skerrett SJ, Stapleton RD, Ware LB, Waldmann CS. Executive summary: management of the critically ill patient with severe acute pancreatitis. Proc Am Thorac Soc. 2004; 1(4):289-90. PMID: 16113448.
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    81. Danielson DS, Heagy W, Nieman KM, West M. Relative hyperoxia augments lipopolysaccharide-stimulated cytokine secretion by murine macrophages. Surgery. 2003 May; 133(5):538-46. PMID: 12773982.
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    82. Heagy W, Hansen C, Nieman K, West M. Evidence for a CD14- and serum-independent pathway in the induction of endotoxin-tolerance in human monocytes and THP-1 monocytic cells. Shock. 2003 Apr; 19(4):321-7. PMID: 12688542.
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    83. West M, Boulanger BR, Fogarty C, Tennenberg A, Wiesinger B, Oross M, Wu SC, Fowler C, Morgan N, Kahn JB. Levofloxacin compared with imipenem/cilastatin followed by ciprofloxacin in adult patients with nosocomial pneumonia: a multicenter, prospective, randomized, open-label study. Clin Ther. 2003 Feb; 25(2):485-506. PMID: 12749509.
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    84. Heagy W, Nieman K, Hansen C, Cohen M, Danielson D, West M. Lower levels of whole blood LPS-stimulated cytokine release are associated with poorer clinical outcomes in surgical ICU patients. Surg Infect (Larchmt). 2003; 4(2):171-80. PMID: 12906717.
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    85. Yellin AE, Hassett JM, Fernandez A, Geib J, Adeyi B, Woods GL, Teppler H. Ertapenem monotherapy versus combination therapy with ceftriaxone plus metronidazole for treatment of complicated intra-abdominal infections in adults. Int J Antimicrob Agents. 2002 Sep; 20(3):165-73. PMID: 12385694.
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    86. West M, Heagy W. Endotoxin tolerance: a review. Crit Care Med. 2002 Jan; 30(1 Suppl):S64-73. PMID: 11782563.
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    87. West M, Heagy W. Endotoxin tolerance: A review. Crit Care Med. 2002 Jan; 30(1 Supp):S64-S73. PMID: 11891406.
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    88. Muehlstedt SG, Richardson CJ, West M, Lyte M, Rodriguez JL. Cytokines and the pathogenesis of nosocomial pneumonia. Surgery. 2001 Oct; 130(4):602-9; discussion 609-11. PMID: 11602890.
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    89. Rodriguez JL, Peterson DJ, Muehlstedt SG, Zera RT, West M, Bubrick MP. The impact of managed care and current governmental policies on an urban academic health care center. Surgery. 2001 Oct; 130(4):539-44; discussion 544-5. PMID: 11602882.
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    90. Danielson D, West M. Recent developments in clinical management of surgical sepsis. Curr Opin Crit Care. 2001 Oct; 7(5):367-70. PMID: 11805535.
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    91. Morken J, West M. Abdominal compartment syndrome in the intensive care unit. Curr Opin Crit Care. 2001 Aug; 7(4):268-74. PMID: 11571425.
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    92. Asensio JA, Chahwan S, Forno W, MacKersie R, Wall M, Lake J, Minard G, Kirton O, Nagy K, Karmy-Jones R, Brundage S, Hoyt D, Winchell R, Kralovich K, Shapiro M, Falcone R, McGuire E, Ivatury R, Stoner M, Yelon J, Ledgerwood A, Luchette F, Schwab CW, Frankel H, Chang B, Coscia R, Maull K, Wang D, Hirsch E, Cue J, Schmacht D, Dunn E, Miller F, Powell M, Sherck J, Enderson B, Rue L, Warren R, Rodriquez J, West M, Weireter L, Britt LD, Dries D, Dunham CM, Malangoni M, Fallon W, Simon R, Bell R, Hanpeter D, Gambaro E, Ceballos J, Torcal J, Alo K, Ramicone E, Chan L. Penetrating esophageal injuries: multicenter study of the American Association for the Surgery of Trauma. J Trauma. 2001 Feb; 50(2):289-96. PMID: 11242294.
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    93. Wahlstrom K, Ney AL, Jacobson S, Odland MD, Van Camp JM, Rodriguez JL, West M. Trauma in cirrhotics: survival and hospital sequelae in patients requiring abdominal exploration. Am Surg. 2000 Nov; 66(11):1071-6. PMID: 11090023.
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    94. Heagy W, Hansen C, Nieman K, Rodriguez JL, West M. Impaired mitogen-activated protein kinase activation and altered cytokine secretion in endotoxin-tolerant human monocytes. J Trauma. 2000 Nov; 49(5):806-14. PMID: 11086768.
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    95. Witzke JD, Kraatz JJ, Morken JM, Ney AL, West M, Van Camp JM, Zera RT, Rodriguez JL. Stapled versus hand sewn anastomoses in patients with small bowel injury: a changing perspective. J Trauma. 2000 Oct; 49(4):660-5; discussion 665-6. PMID: 11038083.
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    96. Hansen CJ, Bernadas C, West M, Ney AL, Muehlstedt S, Cohen M, Rodriguez JL. Abdominal vena caval injuries: outcomes remain dismal. Surgery. 2000 Oct; 128(4):572-8. PMID: 11015090.
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    97. Rodriguez JL, Jacobs DM, Zera RT, Van Camp JM, Muehlstedt SG, West M, Bubrick MP. Academic practice groups: strategy for survival. Surgery. 2000 Oct; 128(4):505-12. PMID: 11015082.
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    98. Heagy W, Hansen C, Nieman K, Cohen M, Richardson C, Rodriguez JL, West M. Impaired ex vivo lipopolysaccharide-stimulated whole blood tumor necrosis factor production may identify "septic" intensive care unit patients. Shock. 2000 Sep; 14(3):271-6; discussion 276-7. PMID: 11028542.
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    99. West M, Clair L, Bellingham J, Wahlstrom K, Rodriguez JL. Defective lipopolysaccharide-dependent ERK 1/2 activation in endotoxin tolerant murine macrophages is reversed by direct protein kinase C stimulation. Shock. 2000 Aug; 14(2):169-75. PMID: 10947162.
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    100. West M, Clair L, Kraatz J, Rodriguez JL. Endotoxin tolerance from lipopolysaccharide pretreatment induces nuclear factor-kappaB alterations not present in C3H/HeJ mice. J Trauma. 2000 Aug; 49(2):298-305. PMID: 10963543.
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    101. West M, Prescott AR, Eskelinen EL, Ridley AJ, Watts C. Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation. Curr Biol. 2000 Jul 13; 10(14):839-48. PMID: 10899002.
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    102. West M, Antoniou AN, Prescott AR, Azuma T, Kwiatkowski DJ, Watts C. Membrane ruffling, macropinocytosis and antigen presentation in the absence of gelsolin in murine dendritic cells. Eur J Immunol. 1999 Nov; 29(11):3450-5. PMID: 10556799.
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    103. Morken JJ, Kraatz JJ, Balcos EG, Hill MJ, Ney AL, West M, Van Camp JM, Zera RT, Jacobs DM, Odland MD, Rodriguez JL. Civilian rectal trauma: a changing perspective. Surgery. 1999 Oct; 126(4):693-8; discussion 698-700. PMID: 10520917.
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    104. Khetarpal S, Steinbrunn BS, McGonigal MD, Stafford R, Ney AL, Kalb DC, West M, Rodriguez JL. Trauma faculty and trauma team activation: impact on trauma system function and patient outcome. J Trauma. 1999 Sep; 47(3):576-81. PMID: 10498319.
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    105. Kraatz J, Clair L, Rodriguez JL, West M. Macrophage TNF secretion in endotoxin tolerance: role of SAPK, p38, and MAPK. J Surg Res. 1999 May 15; 83(2):158-64. PMID: 10329111.
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    106. Lemieur TP, Rodriguez JL, Jacobs DM, Bennett ME, West M. Wound management in perforated appendicitis. Am Surg. 1999 May; 65(5):439-43. PMID: 10231213.
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    107. Wahlstrom K, Bellingham J, Rodriguez JL, West M. Inhibitory kappaBalpha control of nuclear factor-kappaB is dysregulated in endotoxin tolerant macrophages. Shock. 1999 Apr; 11(4):242-7. PMID: 10220299.
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    108. Kraatz J, Clair L, Rodriguez JL, West M. In vitro macrophage endotoxin tolerance: defective in vitro macrophage map kinase signal transduction after LPS pretreatment is not present in macrophages from C3H/HeJ endotoxin resistant mice. Shock. 1999 Jan; 11(1):58-63. PMID: 9921718.
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    109. West M, LeMieur TL, Hackam D, Bellingham J, Claire L, Rodriguez JL. Acetazolamide treatment prevents in vitro endotoxin-stimulated tumor necrosis factor release in mouse macrophages. Shock. 1998 Dec; 10(6):436-41. PMID: 9872684.
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    110. Kraatz J, Clair L, Bellingham J, Wahlstrom K, Rodriguez JL, West M. Lipopolysaccharide pretreatment produces macrophage endotoxin tolerance via a serum-independent pathway. J Trauma. 1998 Oct; 45(4):684-91. PMID: 9783605.
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    111. Kalb DC, Ney AL, Rodriguez JL, Jacobs DM, Van Camp JM, Zera RT, Rockswold GL, West M. Assessment of the relationship between timing of fixation of the fracture and secondary brain injury in patients with multiple trauma. Surgery. 1998 Oct; 124(4):739-44; discussion 744-5. PMID: 9780996.
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    112. Barie PS, Vogel SB, Dellinger EP, Rotstein OD, Solomkin JS, Yang JY, Baumgartner TF. A randomized, double-blind clinical trial comparing cefepime plus metronidazole with imipenem-cilastatin in the treatment of complicated intra-abdominal infections. Cefepime Intra-abdominal Infection Study Group. Arch Surg. 1997 Dec; 132(12):1294-302. PMID: 9403533.
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    113. Carroll MP, Zera RT, Roberts JC, Schlafmann SE, Feeney DA, Johnston GR, West M, Bubrick MP. Efficacy of radioprotective agents in preventing small and large bowel radiation injury. Dis Colon Rectum. 1995 Jul; 38(7):716-22. PMID: 7607031.
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    114. Monafo WW, West M. Current treatment recommendations for topical burn therapy. Drugs. 1990 Sep; 40(3):364-73. PMID: 2226220.
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    115. Bankey PE, Billiar TR, Wang WY, Carlson A, Holman RT, Cerra FB. Modulation of Kupffer cell membrane phospholipid function by n-3 polyunsaturated fatty acids. J Surg Res. 1989 May; 46(5):439-44. PMID: 2541281.
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    116. Cerra FB, West M, Billiar TR, Holman RT, Simmons R. Hepatic dysfunction in multiple systems organ failure as a manifestation of altered cell-cell interaction. Prog Clin Biol Res. 1989; 308:563-73. PMID: 2675063.
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    117. Mazuski JE, Platt JL, West M, Simmons RL, Towle HC, Cerra FB. Direct effects of endotoxin on hepatocytes. Synthesis of a specific secretory protein. Arch Surg. 1988 Mar; 123(3):340-4. PMID: 3341913.
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    118. Cerra FB, West M, Keller G, Mazuski J, Simmons RL. Hypermetabolism/organ failure: the role of the activated macrophage as a metabolic regulator. Prog Clin Biol Res. 1988; 264:27-42. PMID: 3289026.
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    119. Jordan ML, Hoffman RA, Debe EF, West M, Simmons RL. Prostaglandin E2 mediates subset-specific effects on the functional responses of allosensitized T lymphocyte clones. Transplantation. 1987 Jan; 43(1):117-23. PMID: 2948306.
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    120. Keller GA, West M, Cerra FB, Simmons RL. Macrophage-mediated modulation of hepatocyte protein synthesis. Effect of dexamethasone. Arch Surg. 1986 Oct; 121(10):1199-205. PMID: 3490247.
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    121. Keller GA, West M, Cerra FB, Simmons RL. Macrophage-mediated modulation of hepatic function in multiple-system failure. J Surg Res. 1985 Dec; 39(6):555-63. PMID: 3906273.
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    122. West M, Keller GA, Cerra FB, Simmons RL. Killed Escherichia coli stimulates macrophage-mediated alterations in hepatocellular function during in vitro coculture: a mechanism of altered liver function in sepsis. Infect Immun. 1985 Sep; 49(3):563-70. PMID: 3897057; PMCID: PMC261207.
    123. Keller GA, West M, Harty JT, Cerra FB, Simmons RL. Modulation of hepatocyte protein synthesis during co-cultivation with macrophage-rich peritoneal cells in vitro. Arch Surg. 1985 Feb; 120(2):180-6. PMID: 3977588.
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    124. Keller GA, West M, Cerra FB, Simmons RL. Multiple systems organ failure. Modulation of hepatocyte protein synthesis by endotoxin activated Kupffer cells. Ann Surg. 1985 Jan; 201(1):87-95. PMID: 3966830; PMCID: PMC1250623.
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