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Milena Gianfrancesco, PhD, MPH

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-8351-4626 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyPhDEpidemiology; Designated Emphasis in Computational and Genomic Biology
    Yale UniversityMPHChronic Disease Epidemiology
    Brown UniversityBSNeuroscience
    Collapse Awards and Honors
    Rheumatology Research Foundation2017Lawren H. Daltroy Health Professional Preceptorship
    National Institutes of Health, NIAMS2017NIH Loan Repayment Program

    Collapse Research 
    Collapse Research Activities and Funding
    Computational methods using electronic health records and registry data to detect and predict clinical outcomes in rheumatic disease
    NIH/NIAMS K01AR075085Apr 10, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Examining the causal effect of sociodemographic and genetic factors on patient safety outcomes in individuals prescribed high-risk immunosuppressive medications
    NIH/NIAMS F32AR070585Apr 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Direct and indirect effects of obesity genes on multiple sclerosis
    NIH/NINDS F31NS093832Aug 1, 2015 - Jul 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Konig MF, Kim AH, Scheetz MH, Graef ER, Liew JW, Simard J, Machado PM, Gianfrancesco M, Yazdany J, Langguth D, Robinson PC. Baseline use of hydroxychloroquine in systemic lupus erythematosus does not preclude SARS-CoV-2 infection and severe COVID-19. Ann Rheum Dis. 2020 May 07. PMID: 32381561.
      View in: PubMed
    2. Gianfrancesco MA. Initial data from the COVID-19 Global Rheumatology Alliance provider registries - Authors' reply. Lancet Rheumatol. 2020 May 05. PMID: 32377642.
      View in: PubMed
    3. Gianfrancesco MA, Hyrich KL, Gossec L, Strangfeld A, Carmona L, Mateus EF, Sufka P, Grainger R, Wallace Z, Bhana S, Sirotich E, Liew J, Hausmann JS, Costello W, Robinson P, Machado PM, Yazdany J. Rheumatic disease and COVID-19: initial data from the COVID-19 Global Rheumatology Alliance provider registries. Lancet Rheumatol. 2020 Apr 16. PMID: 32309814.
      View in: PubMed
    4. Gandrup J, Li J, Izadi Z, Gianfrancesco M, Ellingsen T, Yazdany J, Schmajuk G. Three Quality Improvement Initiatives and Performance of Rheumatoid Arthritis Disease Activity Measures in Electronic Health Records: Results From an Interrupted Time Series Study. Arthritis Care Res (Hoboken). 2020 Feb; 72(2):283-291. PMID: 30740931.
      View in: PubMed
    5. Lanata CM, Paranjpe I, Nititham J, Taylor KE, Gianfrancesco M, Paranjpe M, Andrews S, Chung SA, Rhead B, Barcellos LF, Trupin L, Katz P, Dall'Era M, Yazdany J, Sirota M, Criswell LA. A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus. Nat Commun. 2019 08 29; 10(1):3902. PMID: 31467281.
      View in: PubMed
    6. Izadi Z, Katz PP, Schmajuk G, Gandrup J, Li J, Gianfrancesco M, Yazdany J. Effects of Language, Insurance, and Race/Ethnicity on Measurement Properties of the PROMIS Physical Function Short Form 10a in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2019 07; 71(7):925-935. PMID: 30099861.
      View in: PubMed
    7. Gianfrancesco MA, Briggs FBS. Does early high body mass index influence onset of pediatric multiple sclerosis? Dev Med Child Neurol. 2019 11; 61(11):1243. PMID: 31044421.
      View in: PubMed
    8. Gianfrancesco MA, Trupin L, McCulloch CE, Shiboski S, Schmajuk G, Yazdany J. Differences in Longitudinal Disease Activity Between Research Cohort and Noncohort Participants with Rheumatoid Arthritis Using Electronic Health Record Data. ACR Open Rheumatol. 2019 Apr; 1(2):113-118. PMID: 31777787.
      View in: PubMed
    9. Ying D, Gianfrancesco MA, Trupin L, Yazdany J, Greidinger EL, Schmajuk G. Increased Risk of Ischemic Stroke in Systemic Sclerosis: A National Cohort Study of US Veterans. J Rheumatol. 2020 Jan; 47(1):82-88. PMID: 30877213.
      View in: PubMed
    10. Norgeot B, Glicksberg BS, Trupin L, Lituiev D, Gianfrancesco M, Oskotsky B, Schmajuk G, Yazdany J, Butte AJ. Assessment of a Deep Learning Model Based on Electronic Health Record Data to Forecast Clinical Outcomes in Patients With Rheumatoid Arthritis. JAMA Netw Open. 2019 03 01; 2(3):e190606. PMID: 30874779.
      View in: PubMed
    11. Patterson S, Schmajuk G, Evans M, Aggarwal I, Izadi Z, Gianfrancesco M, Yazdany J. Gaps in Ambulatory Patient Safety for Immunosuppressive Specialty Medications. Jt Comm J Qual Patient Saf. 2019 May; 45(5):348-357. PMID: 30686706.
      View in: PubMed
    12. Gianfrancesco MA, Trupin L, Shiboski S, van der Laan M, Graf J, Imboden J, Yazdany J, Schmajuk G. Smoking Is Associated with Higher Disease Activity in Rheumatoid Arthritis: A Longitudinal Study Controlling for Time-varying Covariates. J Rheumatol. 2019 04; 46(4):370-375. PMID: 30504507.
      View in: PubMed
    13. Schmajuk G, Jafri K, Evans M, Shiboski S, Gianfrancesco M, Izadi Z, Patterson SL, Aggarwal I, Sarkar U, Dudley RA, Yazdany J. Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs. Semin Arthritis Rheum. 2019 06; 48(6):1087-1092. PMID: 30449650.
      View in: PubMed
    14. Gianfrancesco MA, Tamang S, Yazdany J, Schmajuk G. Potential Biases in Machine Learning Algorithms Using Electronic Health Record Data. JAMA Intern Med. 2018 11 01; 178(11):1544-1547. PMID: 30128552.
      View in: PubMed
    15. Mowry EM, Hedström AK, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Bellesis KH, Briggs FBS, Olsson T, Alfredsson L, Barcellos LF. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. Mult Scler Relat Disord. 2018 Aug; 24:135-141. PMID: 30005356.
      View in: PubMed
    16. Li J, Yazdany J, Trupin L, Izadi Z, Gianfrancesco M, Goglin S, Schmajuk G. Capturing a Patient-Reported Measure of Physical Function Through an Online Electronic Health Record Patient Portal in an Ambulatory Clinic: Implementation Study. JMIR Med Inform. 2018 May 09; 6(2):e31. PMID: 29743158.
      View in: PubMed
    17. Gianfrancesco MA, Yazdany J, Schmajuk G. The impact of smoking on disease measures in rheumatoid arthritis: the need for appropriate adjustment of time-varying confounding. Rheumatol Int. 2018 02; 38(2):313-314. PMID: 29209792.
      View in: PubMed
    18. Jafri K, Ogdie A, Qasim A, Patterson SL, Gianfrancesco M, Izadi Z, Katz P, Yazdany J, Schmajuk G. Discordance of the Framingham cardiovascular risk score and the 2013 American College of Cardiology/American Heart Association risk score in systemic lupus erythematosus and rheumatoid arthritis. Clin Rheumatol. 2018 Feb; 37(2):467-474. PMID: 28993952.
      View in: PubMed
    19. Gianfrancesco MA, Stridh P, Shao X, Rhead B, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Schaefer C, Barcellos LF, Waubant E. Genetic risk factors for pediatric-onset multiple sclerosis. Mult Scler. 2017 Oct 01; 1352458517733551. PMID: 28980494.
      View in: PubMed
    20. Gianfrancesco MA, Schmajuk G, Haserodt S, Trupin L, Izadi Z, Jafri K, Shiboski S, Sirota M, Yazdany J. Hydroxychloroquine dosing in immune-mediated diseases: implications for patient safety. Rheumatol Int. 2017 10; 37(10):1611-1618. PMID: 28748425.
      View in: PubMed
    21. Hedström AK, Katsoulis M, Hössjer O, Bomfim IL, Oturai A, Sondergaard HB, Sellebjerg F, Ullum H, Thørner LW, Gustavsen MW, Harbo HF, Obradovic D, Gianfrancesco MA, Barcellos LF, Schaefer CA, Hillert J, Kockum I, Olsson T, Alfredsson L. The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement. Eur J Epidemiol. 2017 10; 32(10):909-919. PMID: 28597127.
      View in: PubMed
    22. Marshall DA, MacDonald KV, Robinson JO, Barcellos LF, Gianfrancesco M, Helm M, McGuire A, Green RC, Douglas MP, Goldman MA, Phillips KA. The price of whole-genome sequencing may be decreasing, but who will be sequenced? Per Med. 2017 May; 14(3):203-211. PMID: 28993792.
      View in: PubMed
    23. Gianfrancesco MA, Stridh P, Rhead B, Shao X, Xu E, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Bäärnhielm M, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Metayer C, Schaefer C, Barcellos LF, Waubant E. Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Neurology. 2017 Apr 25; 88(17):1623-1629. PMID: 28356466.
      View in: PubMed
    24. Gianfrancesco MA, Glymour MM, Walter S, Rhead B, Shao X, Shen L, Quach H, Hubbard A, Jónsdóttir I, Stefánsson K, Strid P, Hillert J, Hedström A, Olsson T, Kockum I, Schaefer C, Alfredsson L, Barcellos LF. Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility. Am J Epidemiol. 2017 02 01; 185(3):162-171. PMID: 28073764.
      View in: PubMed
    25. Rhead B, Bäärnhielm M, Gianfrancesco M, Mok A, Shao X, Quach H, Shen L, Schaefer C, Link J, Gyllenberg A, Hedström AK, Olsson T, Hillert J, Kockum I, Glymour MM, Alfredsson L, Barcellos LF. Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Neurol Genet. 2016 Oct; 2(5):e97. PMID: 27652346.
      View in: PubMed
    26. George MF, Briggs FB, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedström A, Shen L, Bernstein A, Alfredsson L, Hillert J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Søndergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BA, Oksenberg JR, Hauser SL, D'Alfonso S, Leone MA, Martinelli Boneschi F, Sorosina M, van der Mei I, Taylor BV, Zhou Y, Schaefer C, Barcellos LF. Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies. Neurol Genet. 2016 Aug; 2(4):e87. PMID: 27540591.
      View in: PubMed
    27. Gianfrancesco MA, Balzer L, Taylor KE, Trupin L, Nititham J, Seldin MF, Singer AW, Criswell LA, Barcellos LF. Genetic risk and longitudinal disease activity in systemic lupus erythematosus using targeted maximum likelihood estimation. Genes Immun. 2016 09; 17(6):358-62. PMID: 27467283.
      View in: PubMed
    28. Hedström AK, Mowry EM, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Olsson T, Barcellos LF, Alfredsson L. High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies. J Neurol Neurosurg Psychiatry. 2016 May; 87(5):454-60. PMID: 26940586.
      View in: PubMed
    29. Gianfrancesco MA, Barcellos LF. Obesity and Multiple Sclerosis Susceptibility: A Review. J Neurol Neuromedicine. 2016; 1(7):1-5. PMID: 27990499.
      View in: PubMed
    30. Gianfrancesco MA, Acuna B, Shen L, Briggs FB, Quach H, Bellesis KH, Bernstein A, Hedstrom AK, Kockum I, Alfredsson L, Olsson T, Schaefer C, Barcellos LF. Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Obes Res Clin Pract. 2014 Sep-Oct; 8(5):e435-47. PMID: 25263833.
      View in: PubMed
    31. Hedström AK, Lima Bomfim I, Barcellos L, Gianfrancesco M, Schaefer C, Kockum I, Olsson T, Alfredsson L. Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Neurology. 2014 Mar 11; 82(10):865-72. PMID: 24500647.
      View in: PubMed
    32. Gianfrancesco MA, Triche EW, Fawcett JA, Labas MP, Patterson TS, Lo AC. Speed- and cane-related alterations in gait parameters in individuals with multiple sclerosis. Gait Posture. 2011 Jan; 33(1):140-2. PMID: 20952198.
      View in: PubMed
    33. Lo AC, Chang VC, Gianfrancesco MA, Friedman JH, Patterson TS, Benedicto DF. Reduction of freezing of gait in Parkinson's disease by repetitive robot-assisted treadmill training: a pilot study. J Neuroeng Rehabil. 2010 Oct 14; 7:51. PMID: 20946640.
      View in: PubMed
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