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Milena Gianfrancesco, PhD, MPH

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone--
ORCID ORCID Icon0000-0002-8351-4626 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyPhDEpidemiology; Designated Emphasis in Computational and Genomic Biology
    Yale UniversityMPHChronic Disease Epidemiology
    Brown UniversityBSNeuroscience; Italian Studies
    Collapse Awards and Honors
    Rheumatology Research Foundation2017Lawren H. Daltroy Health Professional Preceptorship
    National Institutes of Health, NIAMS2017NIH Loan Repayment Program
    Rheumatology Research Foundation2020Career Development Bridge Funding Award: K Supplement

    Collapse Research 
    Collapse Research Activities and Funding
    Computational methods using electronic health records and registry data to detect and predict clinical outcomes in rheumatic disease
    NIH/NIAMS K01AR075085Apr 10, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Examining the causal effect of sociodemographic and genetic factors on patient safety outcomes in individuals prescribed high-risk immunosuppressive medications
    NIH/NIAMS F32AR070585Apr 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Direct and indirect effects of obesity genes on multiple sclerosis
    NIH/NINDS F31NS093832Aug 1, 2015 - Jul 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Race/ethnicity association with COVID-19 outcomes in rheumatic disease: Data from the COVID-19 Global Rheumatology Alliance Physician Registry. Arthritis Rheumatol. 2020 Nov 03. Gianfrancesco MA, Leykina LA, Izadi Z, Taylor T, Sparks JA, Harrison C, Trupin L, Rush S, Schmajuk G, Katz P, Jacobsohn L, Hsu TY, D'Silva KM, Serling-Boyd N, Wallwork R, Todd DJ, Bhana S, Costello W, Grainger R, Hausmann JS, Liew JW, Sirotich E, Sufka P, Wallace ZS, Machado PM, Robinson PC, Yazdany J. PMID: 33146001.
      View in: PubMed   Mentions:    Fields:    
    2. Rheumatology Informatics System for Effectiveness (RISE) Practices See Significant Gains in Rheumatoid Arthritis Quality Measures. Arthritis Care Res (Hoboken). 2020 Sep 16. Izadi Z, Schmajuk G, Gianfrancesco M, Subash M, Evans M, Trupin L, Yazdany J. PMID: 32937026.
      View in: PubMed   Mentions:    Fields:    
    3. Rheumatic disease activity, glucocorticoid use and COVID-19. Response to: 'Comment on 'Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry' by Gianfrancesco et al. Disease activity, rather than glucocorticoid therapy, may be associated with COVID-19 severity in patients with rheumatic musculoskeletal diseases' by Giollo et al. Ann Rheum Dis. 2020 Sep 07. Hyrich KL, Gianfrancesco M, Machado PM, Yazdany J, Robinson PC. PMID: 32895239.
      View in: PubMed   Mentions:    Fields:    
    4. Minimum information about clinical artificial intelligence modeling: the MI-CLAIM checklist. Nat Med. 2020 09; 26(9):1320-1324. Norgeot B, Quer G, Beaulieu-Jones BK, Torkamani A, Dias R, Gianfrancesco M, Arnaout R, Kohane IS, Saria S, Topol E, Obermeyer Z, Yu B, Butte AJ. PMID: 32908275.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Epidemiology and outcomes of novel coronavirus 2019 in patients with immune-mediated inflammatory diseases. Curr Opin Rheumatol. 2020 09; 32(5):434-440. Gianfrancesco M, Yazdany J, Robinson PC. PMID: 32675715.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    6. COVID-19 Global Rheumatology Alliance Registry, anti-IL-6 therapy, shared decision-making and patient outcomes. Response to: 'Correspondence on 'Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry' by Gianfrancesco et al. Compassionate use of tocilizumab in severe COVID-19 with hyperinflammation prior to advent of clinical trials - a real-world district general hospital experience' by Khan et al, 'Comment on 'Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 global rheumatology alliance physician-reported registry' by Gianfrancesco M et al' by Andreica et al and 'COVID-19 outcomes in patients with systemic autoimmune diseases treated with immunomodulatory drugs' by Ansarin et al. Ann Rheum Dis. 2020 Aug 12. Gianfrancesco M, Hyrich KL, Yazdany J, Machado PM, Robinson PC. PMID: 32796043.
      View in: PubMed   Mentions:    Fields:    
    7. More on Covid-19 in Immune-Mediated Inflammatory Diseases. N Engl J Med. 2020 08 20; 383(8):796-797. Briggs FBS, Gianfrancesco MA, George MF. PMID: 32649070.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    8. Reweighting to address nonparticipation and missing data bias in a longitudinal electronic health record study. Ann Epidemiol. 2020 10; 50:48-51.e2. Gianfrancesco MA, McCulloch CE, Trupin L, Graf J, Schmajuk G, Yazdany J. PMID: 32807591.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Response to: 'Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis' by Györfi et al. Ann Rheum Dis. 2020 Jun 30. Gianfrancesco M, Hyrich KL, Yazdany J, Machado PM, Robinson PC. PMID: 32606045.
      View in: PubMed   Mentions:    Fields:    
    10. Mortality among Hospitalized Individuals with Systemic Lupus Erythematosus in the United States between 2006 and 2016. Arthritis Care Res (Hoboken). 2020 Jun 17. Anastasiou C, Trupin L, Glidden DV, Li J, Gianfrancesco M, Shiboski S, Schmajuk G, Yazdany J. PMID: 32558160.
      View in: PubMed   Mentions:    Fields:    
    11. Patients with systemic lupus erythematosus using hydroxychloroquine or chloroquine develop severe COVID-19 at similar frequency as patients not on antimalarials: need to explore antithrombotic benefits for COVID-19 coagulopathy. Response to: 'Clinical course of COVID-19 in patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine' by Carbillon et al. Ann Rheum Dis. 2020 May 31. Konig MF, Gianfrancesco M, Yazdany J, Robinson PC. PMID: 32475834.
      View in: PubMed   Mentions: 1     Fields:    
    12. Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry. Ann Rheum Dis. 2020 07; 79(7):859-866. Gianfrancesco M, Hyrich KL, Al-Adely S, Carmona L, Danila MI, Gossec L, Izadi Z, Jacobsohn L, Katz P, Lawson-Tovey S, Mateus EF, Rush S, Schmajuk G, Simard J, Strangfeld A, Trupin L, Wysham KD, Bhana S, Costello W, Grainger R, Hausmann JS, Liew JW, Sirotich E, Sufka P, Wallace ZS, Yazdany J, Machado PM, Robinson PC. PMID: 32471903.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCellsPHPublic Health
    13. Baseline use of hydroxychloroquine in systemic lupus erythematosus does not preclude SARS-CoV-2 infection and severe COVID-19. Ann Rheum Dis. 2020 10; 79(10):1386-1388. Konig MF, Kim AH, Scheetz MH, Graef ER, Liew JW, Simard J, Machado PM, Gianfrancesco M, Yazdany J, Langguth D, Robinson PC. PMID: 32381561.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsPHPublic Health
    14. Initial data from the COVID-19 Global Rheumatology Alliance provider registries - Authors' reply. Lancet Rheumatol. 2020 Jun; 2(6):e317. Gianfrancesco MA. PMID: 32377642.
      View in: PubMed   Mentions:
    15. Rheumatic disease and COVID-19: initial data from the COVID-19 Global Rheumatology Alliance provider registries. Lancet Rheumatol. 2020 May; 2(5):e250-e253. Gianfrancesco MA, Hyrich KL, Gossec L, Strangfeld A, Carmona L, Mateus EF, Sufka P, Grainger R, Wallace Z, Bhana S, Sirotich E, Liew J, Hausmann JS, Costello W, Robinson P, Machado PM, Yazdany J. PMID: 32309814.
      View in: PubMed   Mentions:
    16. Three Quality Improvement Initiatives and Performance of Rheumatoid Arthritis Disease Activity Measures in Electronic Health Records: Results From an Interrupted Time Series Study. Arthritis Care Res (Hoboken). 2020 02; 72(2):283-291. Gandrup J, Li J, Izadi Z, Gianfrancesco M, Ellingsen T, Yazdany J, Schmajuk G. PMID: 30740931.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus. Nat Commun. 2019 08 29; 10(1):3902. Lanata CM, Paranjpe I, Nititham J, Taylor KE, Gianfrancesco M, Paranjpe M, Andrews S, Chung SA, Rhead B, Barcellos LF, Trupin L, Katz P, Dall'Era M, Yazdany J, Sirota M, Criswell LA. PMID: 31467281.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Effects of Language, Insurance, and Race/Ethnicity on Measurement Properties of the PROMIS Physical Function Short Form 10a in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2019 07; 71(7):925-935. Izadi Z, Katz PP, Schmajuk G, Gandrup J, Li J, Gianfrancesco M, Yazdany J. PMID: 30099861.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Does early high body mass index influence onset of pediatric multiple sclerosis? Dev Med Child Neurol. 2019 11; 61(11):1243. Gianfrancesco MA, Briggs FBS. PMID: 31044421.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Differences in Longitudinal Disease Activity Between Research Cohort and Noncohort Participants with Rheumatoid Arthritis Using Electronic Health Record Data. ACR Open Rheumatol. 2019 Apr; 1(2):113-118. Gianfrancesco MA, Trupin L, McCulloch CE, Shiboski S, Schmajuk G, Yazdany J. PMID: 31777787.
      View in: PubMed   Mentions:
    21. Increased Risk of Ischemic Stroke in Systemic Sclerosis: A National Cohort Study of US Veterans. J Rheumatol. 2020 01; 47(1):82-88. Ying D, Gianfrancesco MA, Trupin L, Yazdany J, Greidinger EL, Schmajuk G. PMID: 30877213.
      View in: PubMed   Mentions: 2     Fields:    
    22. Assessment of a Deep Learning Model Based on Electronic Health Record Data to Forecast Clinical Outcomes in Patients With Rheumatoid Arthritis. JAMA Netw Open. 2019 03 01; 2(3):e190606. Norgeot B, Glicksberg BS, Trupin L, Lituiev D, Gianfrancesco M, Oskotsky B, Schmajuk G, Yazdany J, Butte AJ. PMID: 30874779.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    23. Gaps in Ambulatory Patient Safety for Immunosuppressive Specialty Medications. Jt Comm J Qual Patient Saf. 2019 05; 45(5):348-357. Patterson S, Schmajuk G, Evans M, Aggarwal I, Izadi Z, Gianfrancesco M, Yazdany J. PMID: 30686706.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Smoking Is Associated with Higher Disease Activity in Rheumatoid Arthritis: A Longitudinal Study Controlling for Time-varying Covariates. J Rheumatol. 2019 04; 46(4):370-375. Gianfrancesco MA, Trupin L, Shiboski S, van der Laan M, Graf J, Imboden J, Yazdany J, Schmajuk G. PMID: 30504507.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs. Semin Arthritis Rheum. 2019 06; 48(6):1087-1092. Schmajuk G, Jafri K, Evans M, Shiboski S, Gianfrancesco M, Izadi Z, Patterson SL, Aggarwal I, Sarkar U, Dudley RA, Yazdany J. PMID: 30449650.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    26. Potential Biases in Machine Learning Algorithms Using Electronic Health Record Data. JAMA Intern Med. 2018 11 01; 178(11):1544-1547. Gianfrancesco MA, Tamang S, Yazdany J, Schmajuk G. PMID: 30128552.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    27. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. Mult Scler Relat Disord. 2018 Aug; 24:135-141. Mowry EM, Hedström AK, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Bellesis KH, Briggs FBS, Olsson T, Alfredsson L, Barcellos LF. PMID: 30005356.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    28. Capturing a Patient-Reported Measure of Physical Function Through an Online Electronic Health Record Patient Portal in an Ambulatory Clinic: Implementation Study. JMIR Med Inform. 2018 May 09; 6(2):e31. Li J, Yazdany J, Trupin L, Izadi Z, Gianfrancesco M, Goglin S, Schmajuk G. PMID: 29743158.
      View in: PubMed   Mentions:
    29. The impact of smoking on disease measures in rheumatoid arthritis: the need for appropriate adjustment of time-varying confounding. Rheumatol Int. 2018 02; 38(2):313-314. Gianfrancesco MA, Yazdany J, Schmajuk G. PMID: 29209792.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Discordance of the Framingham cardiovascular risk score and the 2013 American College of Cardiology/American Heart Association risk score in systemic lupus erythematosus and rheumatoid arthritis. Clin Rheumatol. 2018 Feb; 37(2):467-474. Jafri K, Ogdie A, Qasim A, Patterson SL, Gianfrancesco M, Izadi Z, Katz P, Yazdany J, Schmajuk G. PMID: 28993952.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Genetic risk factors for pediatric-onset multiple sclerosis. Mult Scler. 2018 12; 24(14):1825-1834. Gianfrancesco MA, Stridh P, Shao X, Rhead B, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Schaefer C, Barcellos LF, Waubant E. PMID: 28980494.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    32. Hydroxychloroquine dosing in immune-mediated diseases: implications for patient safety. Rheumatol Int. 2017 10; 37(10):1611-1618. Gianfrancesco MA, Schmajuk G, Haserodt S, Trupin L, Izadi Z, Jafri K, Shiboski S, Sirota M, Yazdany J. PMID: 28748425.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement. Eur J Epidemiol. 2017 10; 32(10):909-919. Hedström AK, Katsoulis M, Hössjer O, Bomfim IL, Oturai A, Sondergaard HB, Sellebjerg F, Ullum H, Thørner LW, Gustavsen MW, Harbo HF, Obradovic D, Gianfrancesco MA, Barcellos LF, Schaefer CA, Hillert J, Kockum I, Olsson T, Alfredsson L. PMID: 28597127.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    34. The price of whole-genome sequencing may be decreasing, but who will be sequenced? Per Med. 2017 May; 14(3):203-211. Marshall DA, MacDonald KV, Robinson JO, Barcellos LF, Gianfrancesco M, Helm M, McGuire A, Green RC, Douglas MP, Goldman MA, Phillips KA. PMID: 28993792.
      View in: PubMed   Mentions: 2     Fields:    
    35. Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Neurology. 2017 Apr 25; 88(17):1623-1629. Gianfrancesco MA, Stridh P, Rhead B, Shao X, Xu E, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Bäärnhielm M, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Metayer C, Schaefer C, Barcellos LF, Waubant E. PMID: 28356466.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    36. Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility. Am J Epidemiol. 2017 02 01; 185(3):162-171. Gianfrancesco MA, Glymour MM, Walter S, Rhead B, Shao X, Shen L, Quach H, Hubbard A, Jónsdóttir I, Stefánsson K, Strid P, Hillert J, Hedström A, Olsson T, Kockum I, Schaefer C, Alfredsson L, Barcellos LF. PMID: 28073764.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    37. Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Neurol Genet. 2016 Oct; 2(5):e97. Rhead B, Bäärnhielm M, Gianfrancesco M, Mok A, Shao X, Quach H, Shen L, Schaefer C, Link J, Gyllenberg A, Hedström AK, Olsson T, Hillert J, Kockum I, Glymour MM, Alfredsson L, Barcellos LF. PMID: 27652346.
      View in: PubMed   Mentions:
    38. Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies. Neurol Genet. 2016 Aug; 2(4):e87. George MF, Briggs FB, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedström A, Shen L, Bernstein A, Alfredsson L, Hillert J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Søndergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BA, Oksenberg JR, Hauser SL, D'Alfonso S, Leone MA, Martinelli Boneschi F, Sorosina M, van der Mei I, Taylor BV, Zhou Y, Schaefer C, Barcellos LF. PMID: 27540591.
      View in: PubMed   Mentions:
    39. Genetic risk and longitudinal disease activity in systemic lupus erythematosus using targeted maximum likelihood estimation. Genes Immun. 2016 09; 17(6):358-62. Gianfrancesco MA, Balzer L, Taylor KE, Trupin L, Nititham J, Seldin MF, Singer AW, Criswell LA, Barcellos LF. PMID: 27467283.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies. J Neurol Neurosurg Psychiatry. 2016 May; 87(5):454-60. Hedström AK, Mowry EM, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Olsson T, Barcellos LF, Alfredsson L. PMID: 26940586.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    41. Obesity and Multiple Sclerosis Susceptibility: A Review. J Neurol Neuromedicine. 2016; 1(7):1-5. Gianfrancesco MA, Barcellos LF. PMID: 27990499.
      View in: PubMed   Mentions:
    42. Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Obes Res Clin Pract. 2014 Sep-Oct; 8(5):e435-47. Gianfrancesco MA, Acuna B, Shen L, Briggs FB, Quach H, Bellesis KH, Bernstein A, Hedstrom AK, Kockum I, Alfredsson L, Olsson T, Schaefer C, Barcellos LF. PMID: 25263833.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    43. Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Neurology. 2014 Mar 11; 82(10):865-72. Hedström AK, Lima Bomfim I, Barcellos L, Gianfrancesco M, Schaefer C, Kockum I, Olsson T, Alfredsson L. PMID: 24500647.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    44. Speed- and cane-related alterations in gait parameters in individuals with multiple sclerosis. Gait Posture. 2011 Jan; 33(1):140-2. Gianfrancesco MA, Triche EW, Fawcett JA, Labas MP, Patterson TS, Lo AC. PMID: 20952198.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    45. Reduction of freezing of gait in Parkinson's disease by repetitive robot-assisted treadmill training: a pilot study. J Neuroeng Rehabil. 2010 Oct 14; 7:51. Lo AC, Chang VC, Gianfrancesco MA, Friedman JH, Patterson TS, Benedicto DF. PMID: 20946640.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
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