Mohamad Dandan, PhD

Title(s)Postdoctoral Scholar, Bioengineering
SchoolSchool of Pharmacy
Address555 Mission Bay Blvd. South
ORCID ORCID Icon0000-0002-3751-8968 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, Irvine, Irvine, CAB.S.06/2016Biochemistry and Molecular Biology
    University of California, Berkeley, Berkeley, CAPh.D.05/2022Metabolic Biology
    University of California, San Francisco, San Francisco, CAPresentBiophysics and Structural Biology
    Collapse Awards and Honors
    University of California, Irvine2015  - 2016Minority Access to Research Careers (MARC) Scholar
    University of California, Irvine2015  - 2016Minority Health and Health Disparities International Research Training (MHIRT) Scholar
    University of California, Irvine2016  - 2016Honorable mention for the 2016 American Association for the Advancement of Science (AAAS) meeting
    University of California, Berkeley2016  - 2022UC Berkeley Chancellor Fellowship for Graduate Studies
    University of California, Berkeley2017  - 2018AAAS/Science Program for Excellence in Science
    University of California, Berkeley2018  - 2019Li-Chang Chu Fellowship for graduate studies in the Metabolic Biology Ph.D. program
    University of California, Berkeley2018  - 20191st place award winner in the category of physiology and immunology at Sigma Xi annual conference
    University of California, Berkeley2021  - 2022University of California-Dissertation Year Fellowship
    University of California, San Francisco 2022  - 2023UCSF Cardiovascular Research Institute Postdoctoral Scholar T32 Fellowship (declined)
    University of California, San Francisco2022  - 2025Diversity supplement to R01HL159457 (declined)

    Collapse Overview 
    Collapse Overview
    My name is Mohamad Dandan and I hail from Southern California where I was raised on a ten acre farm, descending from a Lebanese and Costa Rican lineage. I am a first-generation, underrepresented minority that strives for increasing diversity in STEM. This would not be possible without completing my Bachelor of Science with a major in Biochemistry and Molecular Biology at the University of California, Irvine. Recently, I completed my PhD in Metabolic Biology at the University of California, Berkeley in the Department of Nutritional Science and Toxicology where I conducted research in the lab of Dr. Marc Hellerstein. The overarching theme in our lab involves the development and application of stable isotopic metabolic labeling with heavy water combined with tandem mass spectrometry to measure the kinetics of biological molecules in metabolic pathways to address these unmeet needs in human health and disease. My dissertation focused on the kinetics of low abundant molecules including receptors, hormones and signaling molecules using heavy water labeling and mass spectrometry.

    For my postdoctoral studies, I decided to obtain training in Biophysics and Structural Biology across the bay at the University of California, San Francisco in Dr. James Fraser's lab. The main focus of the lab is on discovering the fundamental principles of macromolecular structure and dynamics. We are interested in defining conformational states that are essential for function and understanding how conformational transitions couple to biological mechanisms. Specifically, I am training on Cryogenic Electron Microscopy methods to study ribosomal structures of M. tuberculosis. I hope to integrate both fields of metabolism and biophysics.
    Collapse Global Health Equity

    Collapse Research 
    Collapse Research Activities and Funding
    Minority Health and Health Disparities International Research Training
    NIH MD01485Jun 25, 2016 - Sep 1, 2016
    Role: Investigator
    Description: I conducted research abroad in Madrid, Spain, sponsored by the NIH Minority Health Disparities International Research Training program (MHIRT). This ten-week research project conducted a genetic analysis of the Hepatitis C Virus (HCV) NS5A gene, a main gene involved in regulating the HCV replicase, to understand how this gene is involved in viral population dynamics. This research aided in the development of novel therapeutics targeted at viral evolution. I implemented molecular cloning and Sanger sequencing of NS5A. We determined that when HCV is passaged in a cell culture exposed to antivirals that HCV exhibits moderate mutation frequency in NS5A to evade detection from the host and therapeutics.
    MARC U*STAR at the University of California, Irvine
    NIH T34GM069337Sep 1, 2003 - May 31, 2020
    Role: Co-Investigator
    MBRS IMSD Program at the University of California, Irvine
    NIH R25GM055246Sep 30, 1996 - Dec 31, 2022
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aging alters the metabolic flux signature of the ER-unfolded protein response in vivo in mice. Aging Cell. 2022 03; 21(3):e13558. Ward CP, Peng L, Yuen S, Halstead J, Palacios H, Nyangau E, Mohammed H, Ziari N, Dandan M, Frakes AE, Gildea HK, Dillin A, Hellerstein MK. PMID: 35170180; PMCID: PMC8920450.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes. Int J Mol Sci. 2022 Jan 19; 23(3). Ward CP, Peng L, Yuen S, Chang M, Karapetyan R, Nyangau E, Mohammed H, Palacios H, Ziari N, Joe LK, Frakes AE, Dandan M, Dillin A, Hellerstein MK. PMID: 35162995; PMCID: PMC8835023.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Dietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease. J Clin Invest. 2021 12 15; 131(24). Cohen CC, Li KW, Alazraki AL, Beysen C, Carrier CA, Cleeton RL, Dandan M, Figueroa J, Knight-Scott J, Knott CJ, Newton KP, Nyangau EM, Sirlin CB, Ugalde-Nicalo PA, Welsh JA, Hellerstein MK, Schwimmer JB, Vos MB. PMID: 34907907; PMCID: PMC8670836.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    4. Turnover Rates of the Low-Density Lipoprotein Receptor and PCSK9: Added Dimension to the Cholesterol Homeostasis Model. Arterioscler Thromb Vasc Biol. 2021 12; 41(12):2866-2876. Dandan M, Han J, Mann S, Kim R, Mohammed H, Nyangau E, Hellerstein M. PMID: 34615375.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. The role of striated muscle Pik3r1 in glucose and protein metabolism following chronic glucocorticoid exposure. J Biol Chem. 2021 Jan-Jun; 296:100395. Chen TC, Kuo T, Dandan M, Lee RA, Chang M, Villivalam SD, Liao SC, Costello D, Shankaran M, Mohammed H, Kang S, Hellerstein MK, Wang JC. PMID: 33567340; PMCID: PMC8010618.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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