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Montgomery Bissell, JR, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-502-5356
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityA.B1962Harvard College
    Harvard UniversityM.D.1967School of Medicine
    Boston City HospitalResidency1970Harvard Medical Services
    University of California, San FranciscoLiver Research1973School of Medicine
    Collapse Awards and Honors
    American Society for Clinical Investigation1977  - --Member
    American Association for the Study of Liver Diseases1994  - 1995President
    NIDDK/NIH1997  - 2001Advisory Council
    NIDDK/NIH1998  - 2004MERIT award
    American Association for the Study of Liver Diseases2004Distinguished Achievement Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    REGULATION OF THE FIBRONECTIN GENE IN LIVER CELLS
    NIH R03TW000717Sep 1, 1996 - Aug 31, 2000
    Role: Principal Investigator
    MATRIX-DEGRADING PROTEINASES AND HEPATIC FIBROSIS
    NIH R01DK039506Sep 1, 1988 - Aug 31, 1991
    Role: Principal Investigator
    UCSF Liver Center
    NIH/NIDDK P30DK026743Jul 1, 1985 - May 31, 2023
    Role: Principal Investigator
    LIVER CORE CENTER
    NIH P30AM026743Jul 1, 1985 - Jun 30, 1990
    Role: Co-Investigator
    CELLULAR PATHOPHYSIOLOGY OF HEPATIC FIBROSIS
    NIH R37DK031198Jul 1, 1982 - Jun 30, 2004
    Role: Principal Investigator
    CELLULAR PATHOPHYSIOLOGY OF HEPATIC FIBROSIS
    NIH R01DK031198Jul 1, 1982 - Jun 30, 1995
    Role: Principal Investigator
    CELLULAR PATHOPHYSIOLOGY OF HEPATIC FIBROSIS
    NIH R01AM031198Jul 1, 1982 - Jun 30, 1990
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sardh E, Harper P, Balwani M, Stein P, Rees D, Bissell DM, Desnick R, Parker C, Phillips J, Bonkovsky HL, Vassiliou D, Penz C, Chan-Daniels A, He Q, Querbes W, Fitzgerald K, Kim JB, Garg P, Vaishnaw A, Simon AR, Anderson KE. Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria. N Engl J Med. 2019 02 07; 380(6):549-558. PMID: 30726693.
      View in: PubMed
    2. Wang B, Balwani M, Bonkovsky HL, Anderson KE, Bloomer JR, Bissell DM, Phillips JD, Desnick RJ. Reply. Hepatology. 2018 02; 67(2):803-804. PMID: 29159969.
      View in: PubMed
    3. Bissell DM, Anderson KE, Bonkovsky HL. Porphyria. N Engl J Med. 2017 11 23; 377(21):2101. PMID: 29166231.
      View in: PubMed
    4. Bissell DM, Anderson KE, Bonkovsky HL. Porphyria. N Engl J Med. 2017 Aug 31; 377(9):862-872. PMID: 28854095.
      View in: PubMed
    5. Langendonk JG, Balwani M, Anderson KE, Bonkovsky HL, Anstey AV, Bissell DM, Bloomer J, Edwards C, Neumann NJ, Parker C, Phillips JD, Lim HW, Hamzavi I, Deybach JC, Kauppinen R, Rhodes LE, Frank J, Murphy GM, Karstens FPJ, Sijbrands EJG, de Rooij FWM, Lebwohl M, Naik H, Goding CR, Wilson JHP, Desnick RJ. Afamelanotide for Erythropoietic Protoporphyria. N Engl J Med. 2015 Jul 02; 373(1):48-59. PMID: 26132941.
      View in: PubMed
    6. Bissell DM, Wang B. Acute Hepatic Porphyria. J Clin Transl Hepatol. 2015 Mar; 3(1):17-26. PMID: 26357631.
      View in: PubMed
    7. Bissell DM, Lai JC, Meister RK, Blanc PD. Role of delta-aminolevulinic acid in the symptoms of acute porphyria. Am J Med. 2015 Mar; 128(3):313-7. PMID: 25446301.
      View in: PubMed
    8. Bissell DM. Therapy for hepatic fibrosis: revisiting the preclinical models. Clin Res Hepatol Gastroenterol. 2011 Sep; 35(8-9):521-5. PMID: 21536514.
      View in: PubMed
    9. Bissell DM. Inflammation and hepatic fibrosis. Semin Liver Dis. 2010 Aug; 30(3):211-4. PMID: 20665373.
      View in: PubMed
    10. Bissell DM. Of mentors, mentoring, and extracellular matrix. Hepatology. 2009 Nov; 50(5):1330-8. PMID: 19877296.
      View in: PubMed
    11. Wang B, Dolinski BM, Kikuchi N, Leone DR, Peters MG, Weinreb PH, Violette SM, Bissell DM. Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology. 2007 Nov; 46(5):1404-12. PMID: 17924447.
      View in: PubMed
    12. Kikuchi S, Griffin CT, Wang SS, Bissell DM. Role of CD44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and CD44v6. J Biol Chem. 2005 Apr 15; 280(15):15398-404. PMID: 15691832.
      View in: PubMed
    13. Chang ML, Chen JC, Alonso CR, Kornblihtt AR, Bissell DM. Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18093-8. PMID: 15604136.
      View in: PubMed
    14. Bissell D. The origin of hepatic myofibroblasts. Mak KM, Leo MA, Lieber CS. Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells [Gastroenterology 1984;87:188-200]. J Hepatol. 2002 Sep; 37(3):298. PMID: 12175623.
      View in: PubMed
    15. Bissell DM. Chronic liver injury, TGF-beta, and cancer. Exp Mol Med. 2001 Dec 31; 33(4):179-90. PMID: 11795478.
      View in: PubMed
    16. Bissell DM, Roulot D, George J. Transforming growth factor beta and the liver. Hepatology. 2001 Nov; 34(5):859-67. PMID: 11679955.
      View in: PubMed
    17. Bissell DM, Gores GJ, Laskin DL, Hoofnagle JH. Drug-induced liver injury: mechanisms and test systems. Hepatology. 2001 Apr; 33(4):1009-13. PMID: 11283870.
      View in: PubMed
    18. George J, Wang SS, Sevcsik AM, Sanicola M, Cate RL, Koteliansky VE, Bissell DM. Transforming growth factor-beta initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform. Am J Pathol. 2000 Jan; 156(1):115-24. PMID: 10623659.
      View in: PubMed
    19. George J, Roulot D, Koteliansky VE, Bissell DM. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12719-24. PMID: 10535989.
      View in: PubMed
    20. Bissell DM. Clinical research funding and GI organizations. Gastrointest Endosc. 1999 Mar; 49(3 Pt 2):S90-3. PMID: 10049458.
      View in: PubMed
    21. Bissell DM. Hepatic fibrosis as wound repair: a progress report. J Gastroenterol. 1998 Apr; 33(2):295-302. PMID: 9605966.
      View in: PubMed
    22. McDonagh AF, Bissell DM. Porphyria and porphyrinology--the past fifteen years. Semin Liver Dis. 1998; 18(1):3-15. PMID: 9516673.
      View in: PubMed
    23. Wang YJ, Wang SS, Bickel M, Guenzler V, Gerl M, Bissell DM. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol. 1998 Jan; 152(1):279-87. PMID: 9422545.
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    24. Racine-Samson L, Rockey DC, Bissell DM. The role of alpha1beta1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture. J Biol Chem. 1997 Dec 05; 272(49):30911-7. PMID: 9388237.
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    25. Bissell DM, Wang SS, Jarnagin WR, Roll FJ. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest. 1995 Jul; 96(1):447-55. PMID: 7615817.
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    26. Housset CN, Rockey DC, Friedman SL, Bissell DM. Hepatic lipocytes: a major target for endothelin-1. J Hepatol. 1995; 22(2 Suppl):55-60. PMID: 7665851.
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    27. Jarnagin WR, Rockey DC, Koteliansky VE, Wang SS, Bissell DM. Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J Cell Biol. 1994 Dec; 127(6 Pt 2):2037-48. PMID: 7806580.
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    28. Housset C, Rockey DC, Bissell DM. Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9266-70. PMID: 8415690.
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    29. Maher JJ, Bissell DM. Cell-matrix interactions in liver. Semin Cell Biol. 1993 Jun; 4(3):189-201. PMID: 7688595.
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    30. Jarnagin WR, Debs RJ, Wang SS, Bissell DM. Cationic lipid-mediated transfection of liver cells in primary culture. Nucleic Acids Res. 1992 Aug 25; 20(16):4205-11. PMID: 1508714.
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    31. McGuire RF, Bissell DM, Boyles J, Roll FJ. Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver. Hepatology. 1992 Jun; 15(6):989-97. PMID: 1592359.
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    32. Hultcrantz R, Bissell DM, Roll FJ. Iron mediates production of a neutrophil chemoattractant by rat hepatocytes metabolizing ethanol. J Clin Invest. 1991 Jan; 87(1):45-9. PMID: 1985111.
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    33. Friedman SL, Bissell DM. Hepatic fibrosis: new insights into pathogenesis. Hosp Pract (Off Ed). 1990 May 15; 25(5):43-50. PMID: 2110174.
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    34. Bissell DM. Hepatic fibrosis: cellular aspects. Ital J Gastroenterol. 1990 Apr; 22(2):83-7. PMID: 2131938.
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    35. Bissell DM, Caron JM, Babiss LE, Friedman JM. Transcriptional regulation of the albumin gene in cultured rat hepatocytes. Role of basement-membrane matrix. Mol Biol Med. 1990 Apr; 7(2):187-97. PMID: 2160575.
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    36. Bissell DM, Friedman SL, Maher JJ, Roll FJ. Connective tissue biology and hepatic fibrosis: report of a conference. Hepatology. 1990 Mar; 11(3):488-98. PMID: 2179098.
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    37. Arthur MJ, Friedman SL, Roll FJ, Bissell DM. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest. 1989 Oct; 84(4):1076-85. PMID: 2551922.
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    38. Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissell DM. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem. 1989 Jun 25; 264(18):10756-62. PMID: 2732246.
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    39. Maher JJ, Bissell DM, Friedman SL, Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. J Clin Invest. 1988 Aug; 82(2):450-9. PMID: 3042806.
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    40. Arenson DM, Friedman SL, Bissell DM. Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycan. Gastroenterology. 1988 Aug; 95(2):441-7. PMID: 3292336.
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    41. Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology. 1988 Apr; 94(4):1053-62. PMID: 3278941.
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    42. Bissell DM. Treatment of acute hepatic porphyria with hematin. J Hepatol. 1988 Feb; 6(1):1-7. PMID: 3346530.
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    43. Bissell DM, Choun MO. The role of extracellular matrix in normal liver. Scand J Gastroenterol Suppl. 1988; 151:1-7. PMID: 3067342.
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