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Nan Jin, PhD

TitlePostdoctoral Scholar
InstitutionUniversity of California San Francisco
DepartmentOtolaryngology
Address550 16th. Street
San Francisco CA 94158
Emailnan.jin@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    East China University of Science and Technology (ECUST), ChinaB.S.06/2012Pharmacology
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences, ChinaPh.D. 01/2018Cancer Pharmacology
    Collapse Awards and Honors
    Chinese Pharmacological Society2017  - 2017Excellent paper in 15th National Academic Conference on Clinical and Translational Medicine
    Shanghai Pharmacological Society2016  - 2016Special award of excellent paper in 17th Annual Meeting of Shanghai Pharmacology Association
    Chinese Academy of Sciences2015  - 2016National Scholarship of University of Chinese Academy of Sciences
    Chinese Academy of Sciences2013  - 2014Excellent Students Awards of University of Chinese Academy of Sciences
    East China University of Science and Technology2012  - 2012Outstanding undergraduate graduation thesis
    East China University of Science and Technology2011  - 2012Outstanding student in science and engineering of ECUST
    Ministry of Education of the People's Republic of China2010  - 2011National Scholarship
    Shanghai Education Committee2010  - 2011Innovative Award in Shanghai Chemical Industry Park Administration
    East China University of Science and Technology2009  - 2010First grade scholarship for the comprehensive course

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jin N, Ma D, Gu J, Shi J, Xu X, Iqbal K, Gong CX, Liu F, Chu D. O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms. Biochem Biophys Res Commun. 2018 02 26; 497(1):194-199. PMID: 29427667.
      View in: PubMed
    2. Gu J, Jin N, Ma D, Chu D, Iqbal K, Gong CX, Liu F. Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain. J Alzheimers Dis. 2018; 62(4):1737-1746. PMID: 29614685.
      View in: PubMed
    3. Chen C, Gu J, Basurto-Islas G, Jin N, Wu F, Gong CX, Iqbal K, Liu F. Up-regulation of casein kinase 1e is involved in tau pathogenesis in Alzheimer's disease. Sci Rep. 2017 Oct 18; 7(1):13478. PMID: 29044200.
      View in: PubMed
    4. Gu J, Wu F, Xu W, Shi J, Hu W, Jin N, Qian W, Wang X, Iqbal K, Gong CX, Liu F. TDP-43 suppresses tau expression via promoting its mRNA instability. Nucleic Acids Res. 2017 Jun 02; 45(10):6177-6193. PMID: 28335005.
      View in: PubMed
    5. Yin X, Jin N, Shi J, Zhang Y, Wu Y, Gong CX, Iqbal K, Liu F. Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Sci Rep. 2017 04 04; 7(1):619. PMID: 28377597.
      View in: PubMed
    6. Jin N, Wu Y, Xu W, Gong CX, Iqbal K, Liu F. C-terminal truncation of GSK-3ß enhances its dephosphorylation by PP2A. FEBS Lett. 2017 Apr; 591(7):1053-1063. PMID: 28267204.
      View in: PubMed
    7. Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, Jin N, Xie Z, Tan M, Lin SH, Geng M, Ding J, Huang M. Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells. J Cell Biol. 2017 02; 216(2):409-424. PMID: 28122957.
      View in: PubMed
    8. Zhang D, Jin N, Sun W, Li X, Liu B, Xie Z, Qu J, Xu J, Yang X, Su Y, Tang S, Han H, Chen D, Ding J, Tan M, Huang M, Geng M. Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity. Oncogene. 2017 05 18; 36(20):2900-2909. PMID: 27991922.
      View in: PubMed
    9. Zeng H, Qu J, Jin N, Xu J, Lin C, Chen Y, Yang X, He X, Tang S, Lan X, Yang X, Chen Z, Huang M, Ding J, Geng M. Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer. Cancer Cell. 2016 09 12; 30(3):459-473. PMID: 27622335.
      View in: PubMed
    10. Li L, Liu F, Jin N, Tang S, Chen Z, Yang X, Ding J, Geng M, Jiang L, Huang M, Cao J. Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2). Bioorg Med Chem Lett. 2016 06 01; 26(11):2600-4. PMID: 27106711.
      View in: PubMed
    11. Xie S, Jin N, Gu J, Shi J, Sun J, Chu D, Zhang L, Dai CL, Gu JH, Gong CX, Iqbal K, Liu F. O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease. Aging Cell. 2016 06; 15(3):455-64. PMID: 26840030.
      View in: PubMed
    12. Chu D, Tan J, Xie S, Jin N, Yin X, Gong CX, Iqbal K, Liu F. GSK-3ß is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner. J Alzheimers Dis. 2016; 49(2):365-75. PMID: 26484916.
      View in: PubMed
    13. Sun W, Xie Z, Liu Y, Zhao D, Wu Z, Zhang D, Lv H, Tang S, Jin N, Jiang H, Tan M, Ding J, Luo C, Li J, Huang M, Geng M. JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. Cancer Res. 2015 Nov 15; 75(22):4923-36. PMID: 26483203.
      View in: PubMed
    14. Jin N, Yin X, Gu J, Zhang X, Shi J, Qian W, Ji Y, Cao M, Gu X, Ding F, Iqbal K, Gong CX, Liu F. Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. J Biol Chem. 2015 Jun 12; 290(24):15219-37. PMID: 25918155; PMCID: PMC4463463.
    15. Jin N, Yin X, Yu D, Cao M, Gong CX, Iqbal K, Ding F, Gu X, Liu F. Truncation and activation of GSK-3ß by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. Sci Rep. 2015 Feb 02; 5:8187. PMID: 25641096; PMCID: PMC4313118.
    16. Liu H, Jin X, Yin X, Jin N, Liu F, Qian W. PKA-CREB Signaling Suppresses Tau Transcription. J Alzheimers Dis. 2015; 46(1):239-48. PMID: 25720403.
      View in: PubMed
    17. Wu D, Huang Y, Kang J, Li K, Bi X, Zhang T, Jin N, Hu Y, Tan P, Zhang L, Yi Y, Shen W, Huang J, Li X, Li X, Xu J, Wang D. ncRDeathDB: A comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system. Autophagy. 2015; 11(10):1917-26. PMID: 26431463; PMCID: PMC4824571 [Available on 10/02/16].
    18. Li Y, Wang C, Miao Z, Bi X, Wu D, Jin N, Wang L, Wu H, Qian K, Li C, Zhang T, Zhang C, Yi Y, Lai H, Hu Y, Cheng L, Leung KS, Li X, Zhang F, Li K, Li X, Wang D. ViRBase: a resource for virus-host ncRNA-associated interactions. Nucleic Acids Res. 2015 Jan; 43(Database issue):D578-82. PMID: 25274736; PMCID: PMC4384010.
    19. Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, Wang Y, Chang H, Qian W, Shi J, Iqbal K, Gong CX, Cheng C, Liu F. Cross talk between PI3K-AKT-GSK-3ß and PP2A pathways determines tau hyperphosphorylation. Neurobiol Aging. 2015 Jan; 36(1):188-200. PMID: 25219467.
      View in: PubMed
    20. Li K, Wu D, Chen X, Zhang T, Zhang L, Yi Y, Miao Z, Jin N, Bi X, Wang H, Xu J, Wang D. Current and emerging biomarkers of cell death in human disease. Biomed Res Int. 2014; 2014:690103. PMID: 24949464; PMCID: PMC4052120.
    21. Zhang X, Wu D, Chen L, Li X, Yang J, Fan D, Dong T, Liu M, Tan P, Xu J, Yi Y, Wang Y, Zou H, Hu Y, Fan K, Kang J, Huang Y, Miao Z, Bi M, Jin N, Li K, Li X, Xu J, Wang D. RAID: a comprehensive resource for human RNA-associated (RNA-RNA/RNA-protein) interaction. RNA. 2014 Jul; 20(7):989-93. PMID: 24803509; PMCID: PMC4114696.
    22. Chen C, Jin N, Qian W, Liu W, Tan X, Ding F, Gu X, Iqbal K, Gong CX, Zuo J, Liu F. Cyclic AMP-dependent protein kinase enhances SC35-promoted Tau exon 10 inclusion. Mol Neurobiol. 2014 Feb; 49(1):615-24. PMID: 24037441.
      View in: PubMed
    23. Jin N, Qian W, Yin X, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease. Nucleic Acids Res. 2013 Mar 01; 41(5):3240-56. PMID: 23341039; PMCID: PMC3597642.
    24. Qian W, Jin N, Shi J, Yin X, Jin X, Wang S, Cao M, Iqbal K, Gong CX, Liu F. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression. J Alzheimers Dis. 2013; 37(3):529-38. PMID: 23948904.
      View in: PubMed
    25. Yin X, Jin N, Gu J, Shi J, Zhou J, Gong CX, Iqbal K, Grundke-Iqbal I, Liu F. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. J Biol Chem. 2012 Aug 31; 287(36):30497-506. PMID: 22767602; PMCID: PMC3436298.
    26. Gu J, Shi J, Wu S, Jin N, Qian W, Zhou J, Iqbal IG, Iqbal K, Gong CX, Liu F. Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10. FEBS Lett. 2012 Jul 30; 586(16):2239-44. PMID: 22677170.
      View in: PubMed
    27. Qian W, Liang H, Shi J, Jin N, Grundke-Iqbal I, Iqbal K, Gong CX, Liu F. Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic Acids Res. 2011 Aug; 39(14):6161-71. PMID: 21470964; PMCID: PMC3152345.
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