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Nancy McNamara, PhD, OD

TitleMS Student
SchoolUCSF School of Medicine
DepartmentAnatomy
Address513 Parnassus Ave, Med Sci
San Francisco CA 94122
Phone415-476-8132
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    Collapse Biography 
    Collapse Education and Training
    University of California BerkeleyOD1996School of Optometry

    Collapse Research 
    Collapse Research Activities and Funding
    Defining the role of immune-neuronal crosstalk in dry eye disease
    NIH/NEI R01EY026492Sep 30, 2016 - Jul 31, 2019
    Role: Co-Principal Investigator
    Defining the role of the nervous system in aqueous-deficient dry eye
    NIH/NEI R01EY025980Aug 1, 2015 - Jun 30, 2020
    Role: Co-Principal Investigator
    Molecular Mechanisms of Squamous Metaplasia in Dry Eye
    NIH/NEI R01EY016203Dec 1, 2004 - Aug 31, 2014
    Role: Principal Investigator
    CONTACT LENS EFFECTS ON HUMAN OCULAR MUCIN
    NIH/NEI K23EY000371Aug 1, 1998 - Jul 31, 2004
    Role: Principal Investigator
    CONTACT LENS EFFECTS ON HUMAN OCULAR MUCIN
    NIH/NEI K08EY000371Aug 1, 1998 - Jul 31, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang L, Gallup M, Zlock L, Feeling Chen YT, Finkbeiner WE, McNamara N. Cigarette Smoke Mediates Nuclear to Cytoplasmic Trafficking of Transcriptional Inhibitor Kaiso through MUC1 and P120-Catenin. Am J Pathol. 2016 Oct 17. PMID: 27765636.
      View in: PubMed
    2. Moy A, McNamara N, Lin MC. Effects of Isotretinoin on Meibomian Glands. Optom Vis Sci. 2015 Sep; 92(9):925-30. PMID: 26154692.
      View in: PubMed
    3. Stephens DN, McNamara N. Altered Mucin and Glycoprotein Expression in Dry Eye Disease. Optom Vis Sci. 2015 Sep; 92(9):931-8. PMID: 26267059.
      View in: PubMed
    4. Rose-Nussbaumer J, Lietman TM, Shiboski CH, Shiboski SC, Bunya VY, Akpek EK, Srinivasan M, Mascarenhas J, Massaro-Giordano G, McNamara N, Whitcher JP, Gaynor BD. Inter-grader Agreement of the Ocular Staining Score in the Sjögren's International Clinical Collaborative Alliance (SICCA) Registry. Am J Ophthalmol. 2015 Dec; 160(6):1150-1153.e3. PMID: 26302236; PMCID: PMC4651820 [Available on 12/01/16].
    5. Rutar T, Youm J, Porco T, Tilton N, Muskat M, McNamara N, Wara D. Ophthalmic manifestations of perinatally acquired HIV in a US cohort of long-term survivors. Br J Ophthalmol. 2015 May; 99(5):650-3. PMID: 25416182.
      View in: PubMed
    6. McNamara N, Gallup M, Porco TC. Establishing PAX6 as a biomarker to detect early loss of ocular phenotype in human patients with Sjögren's syndrome. Invest Ophthalmol Vis Sci. 2014 Nov; 55(11):7079-84. PMID: 25228544; PMCID: PMC4224577.
    7. Vijmasi T, Chen FY, Balasubbu S, Gallup M, McKown RL, Laurie GW, McNamara N. Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease. Invest Ophthalmol Vis Sci. 2014 Aug; 55(8):5401-9. PMID: 25034600; PMCID: PMC4148924.
    8. Zhang L, Gallup M, Zlock L, Chen YT, Finkbeiner WE, McNamara N. Pivotal role of MUC1 glycosylation by cigarette smoke in modulating disruption of airway adherens junctions in vitro. J Pathol. 2014 Sep; 234(1):60-73. PMID: 24838315; PMCID: PMC4138268.
    9. Chen YF, Zhou D, Metzger T, Gallup M, Jeanne M, Gould DB, Anderson MS, McNamara N. Spontaneous development of autoimmune uveitis Is CCR2 dependent. Am J Pathol. 2014 Jun; 184(6):1695-705. PMID: 24736166; PMCID: PMC4044718.
    10. Robertson DM, Alexander LJ, Bonanno JA, Fleiszig SM, McNamara N. Cornea and ocular surface disease: application of cutting-edge optometric research. Optom Vis Sci. 2014 Apr; 91(4 Suppl 1):S3-16. PMID: 24658300; PMCID: PMC4090233.
    11. Zhou D, McNamara N. Macrophages: important players in primary Sjögren's syndrome? Expert Rev Clin Immunol. 2014 Apr; 10(4):513-20. PMID: 24646086.
      View in: PubMed
    12. Chen YT, Chen FY, Vijmasi T, Stephens DN, Gallup M, McNamara N. Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. PLoS One. 2013; 8(10):e77286. PMID: 24143217; PMCID: PMC3797128.
    13. Vijmasi T, Chen FY, Chen YT, Gallup M, McNamara N. Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease. Mol Vis. 2013; 19:1957-65. PMID: 24068863; PMCID: PMC3782366.
    14. Zhang L, Gallup M, Zlock L, Finkbeiner WE, McNamara N. Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways. Am J Pathol. 2013 Jun; 182(6):1986-95. PMID: 23562274.
      View in: PubMed
    15. Zhang L, Gallup M, Zlock L, Basbaum C, Finkbeiner WE, McNamara N. Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1. J Pathol. 2013 Jan; 229(1):74-86. PMID: 22833523; PMCID: PMC4096852.
    16. McNamara N, Carbone LA, Shellhaas RA. Epilepsy characteristics and psychosocial factors associated with ketogenic diet success. J Child Neurol. 2013 Oct; 28(10):1233-7. PMID: 23001929.
      View in: PubMed
    17. Zhou D, Chen YT, Chen F, Gallup M, Vijmasi T, Bahrami AF, Noble LB, van Rooijen N, McNamara N. Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye. Am J Pathol. 2012 Sep; 181(3):753-60. PMID: 22770665; PMCID: PMC3432423.
    18. Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H, Schiødt M, Umehara H, Vivino F, Zhao Y, Dong Y, Greenspan D, Heidenreich AM, Helin P, Kirkham B, Kitagawa K, Larkin G, Li M, Lietman T, Lindegaard J, McNamara N, Sack K, Shirlaw P, Sugai S, Vollenweider C, Whitcher J, Wu A, Zhang S, Zhang W, Greenspan J, Daniels T. American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken). 2012 Apr; 64(4):475-87. PMID: 22563590; PMCID: PMC3349440.
    19. Chen YT, Lazarev S, Bahrami AF, Noble LB, Chen FY, Zhou D, Gallup M, Yadav M, McNamara N. Interleukin-1 receptor mediates the interplay between CD4+ T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjögren's syndrome. Lab Invest. 2012 Apr; 92(4):556-70. PMID: 22231738; PMCID: PMC3725338.
    20. Zhang L, Gallup M, Zlock L, Finkbeiner W, McNamara N. p120-catenin modulates airway epithelial cell migration induced by cigarette smoke. Biochem Biophys Res Commun. 2012 Jan 6; 417(1):49-55. PMID: 22120634; PMCID: PMC4066870.
    21. Amburgey K, McNamara N, Bennett LR, McCormick ME, Acsadi G, Dowling JJ. Prevalence of congenital myopathies in a representative pediatric united states population. Ann Neurol. 2011 Oct; 70(4):662-5. PMID: 22028225.
      View in: PubMed
    22. Chan MF, Sack R, Quigley DA, Sathe S, Vijmasi T, Li S, Holsclaw D, Strauss EC, McNamara N. Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. Optom Vis Sci. 2011 Aug; 88(8):1005-9. PMID: 21552176; PMCID: PMC3667701.
    23. Chen YT, Nikulina K, Lazarev S, Bahrami AF, Noble LB, Gallup M, McNamara N. Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndrome. Am J Pathol. 2010 Sep; 177(3):1333-43. PMID: 20696775; PMCID: PMC2928966.
    24. Chen YT, Gallup M, Nikulina K, Lazarev S, Zlock L, Finkbeiner W, McNamara N. Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells. Am J Pathol. 2010 Sep; 177(3):1255-64. PMID: 20651243; PMCID: PMC2928959.
    25. McNamara N. Molecular mechanisms of keratinizing ocular surface disease. Optom Vis Sci. 2010 Apr; 87(4):233-8. PMID: 20010137.
      View in: PubMed
    26. Li S, Gallup M, Chen YT, McNamara N. Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010 May; 51(5):2466-75. PMID: 20042643; PMCID: PMC2868474.
    27. Whitcher JP, Shiboski CH, Shiboski SC, Heidenreich AM, Kitagawa K, Zhang S, Hamann S, Larkin G, McNamara N, Greenspan JS, Daniels TE. A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International Registry. Am J Ophthalmol. 2010 Mar; 149(3):405-15. PMID: 20035924; PMCID: PMC3459675.
    28. Liu H, Begley C, Chen M, Bradley A, Bonanno J, McNamara N, Nelson JD, Simpson T. A link between tear instability and hyperosmolarity in dry eye. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3671-9. PMID: 19324847.
      View in: PubMed
    29. Chen YT, Li S, Nikulina K, Porco T, Gallup M, McNamara N. Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye. Mol Vis. 2009; 15:563-76. PMID: 19365590; PMCID: PMC2660375.
    30. Sack R, Sathe S, Beaton AR, McNamara N, Fleiszig S, Ni M. Protein array characterization of bioactive proteins secreted by immortalized human corneal epithelium in response to pseudomonas constituents. Curr Eye Res. 2009 Feb; 34(2):92-8. PMID: 19219679.
      View in: PubMed
    31. Li S, Sack R, Vijmasi T, Sathe S, Beaton A, Quigley D, Gallup M, McNamara N. Antibody protein array analysis of the tear film cytokines. Optom Vis Sci. 2008 Aug; 85(8):653-60. PMID: 18677223; PMCID: PMC3786218.
    32. Li S, Nikulina K, DeVoss J, Wu AJ, Strauss EC, Anderson MS, McNamara N. Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):34-41. PMID: 18172072; PMCID: PMC2574421.
    33. Sack R, Conradi L, Beaton A, Sathe S, McNamara N, Leonardi A. Antibody array characterization of inflammatory mediators in allergic and normal tears in the open and closed eye environments. Exp Eye Res. 2007 Oct; 85(4):528-38. PMID: 17719576.
      View in: PubMed
    34. Evans DJ, McNamara N, Fleiszig SM. Life at the front: dissecting bacterial-host interactions at the ocular surface. Ocul Surf. 2007 Jul; 5(3):213-27. PMID: 17660895.
      View in: PubMed
    35. Maltseva IA, Fleiszig SM, Evans DJ, Kerr S, Sidhu SS, McNamara N, Basbaum C. Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa. Exp Eye Res. 2007 Jul; 85(1):142-53. PMID: 17531223.
      View in: PubMed
    36. Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N. Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"? Am J Respir Cell Mol Biol. 2006 Jul; 35(1):3-9. PMID: 16484682.
      View in: PubMed
    37. McNamara N, Gallup M, Sucher A, Maltseva I, McKemy D, Basbaum C. AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):653-60. PMID: 16439799; PMCID: PMC2644226.
    38. McNamara N, Andika R, Kwong M, Sack RA, Fleiszig SM. Interaction of Pseudomonas aeruginosa with human tear fluid components. Curr Eye Res. 2005 Jul; 30(7):517-25. PMID: 16020285.
      View in: PubMed
    39. McNamara N, Gallup M, Khong A, Sucher A, Maltseva I, Fahy J, Basbaum C. Adenosine up-regulation of the mucin gene, MUC2, in asthma. FASEB J. 2004 Nov; 18(14):1770-2. PMID: 15345696.
      View in: PubMed
    40. Londhe V, McNamara N, Lemjabbar H, Basbaum C. Viral dsRNA activates mucin transcription in airway epithelial cells. FEBS Lett. 2003 Oct 9; 553(1-2):33-8. PMID: 14550542.
      View in: PubMed
    41. McNamara N. Innate defense of the ocular surface. Eye Contact Lens. 2003 Jan; 29(1 Suppl):S10-3; discussion S26-9, S192-4. PMID: 12772722.
      View in: PubMed
    42. Fleiszig SM, McNamara N, Evans DJ. The tear film and defense against infection. Adv Exp Med Biol. 2002; 506(Pt A):523-30. PMID: 12613956.
      View in: PubMed
    43. McNamara N, Basbaum C. Mechanism by which bacterial flagellin stimulates host mucin production. Adv Exp Med Biol. 2002; 506(Pt A):269-73. PMID: 12613919.
      View in: PubMed
    44. McNamara N, Basbaum C. Signaling networks controlling mucin production in response to Gram-positive and Gram-negative bacteria. Glycoconj J. 2001 Sep; 18(9):715-22. PMID: 12386457.
      View in: PubMed
    45. Polse KA, Graham AD, Fusaro RE, Gan CM, Rivera RK, Lin MC, Sanders TL, McNamara N, Chan JS. The Berkeley Contact Lens Extended Wear Study. Part II : Clinical results. Ophthalmology. 2001 Aug; 108(8):1389-99. PMID: 11470689.
      View in: PubMed
    46. Fusaro RE, Polse KA, Graham AD, Gan CM, Rivera RK, Lin MC, Sanders TL, McNamara N, Chan JS. The Berkeley Contact Lens Extended Wear Study. Part I : Study design and conduct. Ophthalmology. 2001 Aug; 108(8):1381-8. PMID: 11470688.
      View in: PubMed
    47. McNamara N, Khong A, McKemy D, Caterina M, Boyer J, Julius D, Basbaum C. ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9086-91. PMID: 11481474; PMCID: PMC55377.
    48. Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara N, Lemjabbar H, Basbaum C, Relman DA. The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13847-52. PMID: 11087813; PMCID: PMC17664.
    49. Lin MC, Graham AD, Polse KA, McNamara N, Tieu TG. The effects of one-hour wear of high-Dk soft contact lenses on corneal pH and epithelial permeability. CLAO J. 2000 Jul; 26(3):130-3. PMID: 10946983.
      View in: PubMed
    50. McNamara N, Sack RA, Fleiszig SM. Mucin-bacterial binding assays. Methods Mol Biol. 2000; 125:429-37. PMID: 10820779.
      View in: PubMed
    51. McNAMARA NA, Van R, Tuchin OS, Fleiszig SM. Ocular surface epithelia express mRNA for human beta defensin-2. Exp Eye Res. 1999 Nov; 69(5):483-90. PMID: 10548468.
      View in: PubMed
    52. Basbaum C, Lemjabbar H, Longphre M, Li D, Gensch E, McNamara N. Control of mucin transcription by diverse injury-induced signaling pathways. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 2):S44-8. PMID: 10556169.
      View in: PubMed
    53. Lin MC, Graham AD, Polse KA, Mandell RB, McNamara N. Measurement of post-lens tear thickness. Invest Ophthalmol Vis Sci. 1999 Nov; 40(12):2833-9. PMID: 10549643.
      View in: PubMed
    54. Polse KA, Graham AD, Fusaro RE, Gan CM, Rivera RK, Chan JS, McNamara N, Sanders TS. Predicting RGP daily wear success. CLAO J. 1999 Jul; 25(3):152-8. PMID: 10444051.
      View in: PubMed
    55. McNamara N, Polse KA, Brand RJ, Graham AD, Chan JS, McKenney CD. Tear mixing under a soft contact lens: effects of lens diameter. Am J Ophthalmol. 1999 Jun; 127(6):659-65. PMID: 10372875.
      View in: PubMed
    56. McNamara N, Chan JS, Han SC, Polse KA, McKenney CD. Effects of hypoxia on corneal epithelial permeability. Am J Ophthalmol. 1999 Feb; 127(2):153-7. PMID: 10030556.
      View in: PubMed
    57. McNamara N, Polse KA, Fukunaga SA, Maebori JS, Suzuki RM. Soft lens extended wear affects epithelial barrier function. Ophthalmology. 1998 Dec; 105(12):2330-5. PMID: 9855168.
      View in: PubMed
    58. McNamara N, Polse KA, Bonanno JA. Fluorophotometry in contact lens research: the next step. Optom Vis Sci. 1998 May; 75(5):316-22. PMID: 9624695.
      View in: PubMed
    59. McNamara N, Fusaro RE, Brand RJ, Polse KA. Epithelial permeability reflects subclinical effects of contact lens wear. Br J Ophthalmol. 1998 Apr; 82(4):376-81. PMID: 9640184; PMCID: PMC1722553.
    60. McNamara N, Brand RJ, Polse KA, Bourne WM. Corneal function during normal and high serum glucose levels in diabetes. Invest Ophthalmol Vis Sci. 1998 Jan; 39(1):3-17. PMID: 9430539.
      View in: PubMed
    61. McNamara N, Fleiszig SM. Human tear film components bind Pseudomonas aeruginosa. Adv Exp Med Biol. 1998; 438:653-8. PMID: 9634950.
      View in: PubMed
    62. McNamara N, Fusaro RE, Brand RJ, Polse KA, Srinivas SP. Measurement of corneal epithelial permeability to fluorescein. A repeatability study. Invest Ophthalmol Vis Sci. 1997 Aug; 38(9):1830-9. PMID: 9286273.
      View in: PubMed
    63. Levy B, McNamara N, Corzine J, Abbott RL. Prospective trial of daily and extended wear disposable contact lenses. Cornea. 1997 May; 16(3):274-6. PMID: 9143797.
      View in: PubMed
    64. McMahon TT, Polse KA, McNamara N, Viana MA. Recovery from induced corneal edema and endothelial morphology after long-term PMMA contact lens wear. Optom Vis Sci. 1996 Mar; 73(3):184-8. PMID: 8725020.
      View in: PubMed
    65. Goldberg MA, McNamara N, Nguyen NT, Lerner L, Rosenblum LH, Park DW, Abbott RL, Levy B. Effect of diclofenac sodium (Voltaren) on hypoxia-induced corneal edema in humans. CLAO J. 1995 Jan; 21(1):61-3. PMID: 7712610.
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    66. McNamara N, Polse KA, Bonanno JA. Stromal acidosis modulates corneal swelling. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):846-50. PMID: 8125747.
      View in: PubMed
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