Nathan Schmidt, PhD

TitlePostdoctoral Scholar-Fellow
InstitutionUniversity of California San Francisco
DepartmentPharmaceutical Chemistry
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Collapse Research 
    Collapse Research Activities and Funding
    Defining optimal adaptive immunity for resistance to Plasmodium sporozoites
    NIH/NIAID F32AI084329Aug 1, 2009 - Jul 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bhate MP, Lemmin T, Kuenze G, Mensa B, Ganguly S, Peters J, Schmidt N, Pelton JG, Gross C, Meiler J, DeGrado WF. Structure and function of the transmembrane domain of NsaS, an antibiotic sensing histidine kinase in S. aureus. J Am Chem Soc. 2018 May 17. PMID: 29771498.
      View in: PubMed
    2. Ippolito MM, Denny JE, Langelier C, Sears CL, Schmidt NW. Malaria and the microbiome: a systematic review. Clin Infect Dis. 2018 Apr 26. PMID: 29701835.
      View in: PubMed
    3. Nick M, Wu Y, Schmidt NW, Prusiner SB, Stöhr J, DeGrado WF. A long-lived Aß oligomer resistant to fibrillization. Biopolymers. 2018 Jan 10. PMID: 29319162.
      View in: PubMed
    4. Schnaider L, Brahmachari S, Schmidt NW, Mensa B, Shaham-Niv S, Bychenko D, Adler-Abramovich L, Shimon LJW, Kolusheva S, DeGrado WF, Gazit E. Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. Nat Commun. 2017 Nov 08; 8(1):1365. PMID: 29118336.
      View in: PubMed
    5. Deshayes S, Xian W, Schmidt NW, Kordbacheh S, Lieng J, Wang J, Zarmer S, Germain SS, Voyen L, Thulin J, Wong GC, Kasko AM. Designing Hybrid Antibiotic Peptide Conjugates To Cross Bacterial Membranes. Bioconjug Chem. 2017 03 15; 28(3):793-804. PMID: 28248495.
      View in: PubMed
    6. Schmidt NW, Grigoryan G, DeGrado WF. The accommodation index measures the perturbation associated with insertions and deletions in coiled-coils: Application to understand signaling in histidine kinases. Protein Sci. 2017 Mar; 26(3):414-435. PMID: 27977891.
      View in: PubMed
    7. Stough JM, Dearth SP, Denny JE, LeCleir GR, Schmidt NW, Campagna SR, Wilhelm SW. Functional Characteristics of the Gut Microbiome in C57BL/6 Mice Differentially Susceptible to Plasmodium yoelii. Front Microbiol. 2016; 7:1520. PMID: 27729904.
      View in: PubMed
    8. Li B, Schmidt NW. Epidermal Fatty Acid Binding Protein (E-FABP) Is Not Required for the Generation or Maintenance of Effector and Memory T Cells following Infection with Listeria monocytogenes. PLoS One. 2016; 11(9):e0162427. PMID: 27588422.
      View in: PubMed
    9. Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL. S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS Pathog. 2016 Jun; 12(6):e1005705. PMID: 27355424.
      View in: PubMed
    10. Denny JE, Powell WL, Schmidt NW. Local and Long-Distance Calling: Conversations between the Gut Microbiota and Intra- and Extra-Gastrointestinal Tract Infections. Front Cell Infect Microbiol. 2016; 6:41. PMID: 27148490; PMCID: PMC4826874.
    11. Lee EY, Lee CK, Schmidt NW, Jin F, Lande R, Curk T, Frenkel D, Dobnikar J, Gilliet M, Wong GCL. A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes. Adv Colloid Interface Sci. 2016 06; 232:17-24. PMID: 26956527.
      View in: PubMed
    12. Villarino NF, LeCleir GR, Denny JE, Dearth SP, Harding CL, Sloan SS, Gribble JL, Campagna SR, Wilhelm SW, Schmidt NW. Composition of the gut microbiota modulates the severity of malaria. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2235-40. PMID: 26858424; PMCID: PMC4776451.
    13. Schmidt NW, Jin F, Lande R, Curk T, Xian W, Lee C, Frasca L, Frenkel D, Dobnikar J, Gilliet M, Wong GC. Liquid-crystalline ordering of antimicrobial peptide-DNA complexes controls TLR9 activation. Nat Mater. 2015 Jul; 14(7):696-700. PMID: 26053762.
      View in: PubMed
    14. Butler NS, Schmidt NW. Erythropoietin-producing hepatocellular receptor B2 receptor tyrosine kinase: A novel regulator of infection- and inflammation-induced liver fibrosis. Hepatology. 2015 Sep; 62(3):680-3. PMID: 25914283; PMCID: PMC4549189.
    15. Kramer JR, Schmidt NW, Mayle KM, Kamei DT, Wong GC, Deming TJ. Reinventing Cell Penetrating Peptides Using Glycosylated Methionine Sulfonium Ion Sequences. ACS Cent Sci. 2015 May 27; 1(2):83-8. PMID: 27162954; PMCID: PMC4827470.
    16. Villarino N, Denny JE, Schmidt NW. Antimalarial activity of tulathromycin in a murine model of malaria. Antimicrob Agents Chemother. 2015; 59(6):3672-4. PMID: 25870067; PMCID: PMC4432142.
    17. Schmidt NW, Agak GW, Deshayes S, Yu Y, Blacker A, Champer J, Xian W, Kasko AM, Kim J, Wong GCL. Pentobra: A Potent Antibiotic with Multiple Layers of Selective Antimicrobial Mechanisms against Propionibacterium Acnes. J Invest Dermatol. 2015 Jun; 135(6):1581-1589. PMID: 25668237; PMCID: PMC4430421.
    18. White CE, Villarino NF, Sloan SS, Ganusov VV, Schmidt NW. Plasmodium suppresses expansion of T cell responses to heterologous infections. J Immunol. 2015 Jan 15; 194(2):697-708. PMID: 25505280; PMCID: PMC4282975.
    19. Schmidt NW, Deshayes S, Hawker S, Blacker A, Kasko AM, Wong GC. Engineering persister-specific antibiotics with synergistic antimicrobial functions. ACS Nano. 2014 Sep 23; 8(9):8786-93. PMID: 25130648; PMCID: PMC4173747.
    20. Lee MW, Chakraborty S, Schmidt NW, Murgai R, Gellman SH, Wong GC. Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides. Biochim Biophys Acta. 2014 Sep; 1838(9):2269-79. PMID: 24743021; PMCID: PMC4405380.
    21. Schmidt NW, Mishra A, Wang J, DeGrado WF, Wong GC. Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission. J Am Chem Soc. 2013 Sep 18; 135(37):13710-9. PMID: 23962302; PMCID: PMC4000230.
    22. Schmidt NW, Wong GC. Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering. Curr Opin Solid State Mater Sci. 2013 Aug; 17(4):151-163. PMID: 24778573.
      View in: PubMed
    23. Villarino N, Schmidt NW. CD8+ T Cell Responses to Plasmodium and Intracellular Parasites. Curr Immunol Rev. 2013 Aug; 9(3):169-178. PMID: 24741372.
      View in: PubMed
    24. Hu K, Schmidt NW, Zhu R, Jiang Y, Lai GH, Wei G, Palermo EF, Kuroda K, Wong GC, Yang L. A critical evaluation of random copolymer mimesis of homogeneous antimicrobial peptides. Macromolecules. 2013; 46(5):1908-1915. PMID: 23750051.
      View in: PubMed
    25. Schmidt NW, Lis M, Zhao K, Lai GH, Alexandrova AN, Tew GN, Wong GC. Molecular basis for nanoscopic membrane curvature generation from quantum mechanical models and synthetic transporter sequences. J Am Chem Soc. 2012 Nov 21; 134(46):19207-16. PMID: 23061419; PMCID: PMC4036524.
    26. Schmidt NW, Tai KP, Kamdar K, Mishra A, Lai GH, Zhao K, Ouellette AJ, Wong GC. Arginine in a-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior. J Biol Chem. 2012 Jun 22; 287(26):21866-72. PMID: 22566697; PMCID: PMC3381149.
    27. Coridan RH, Schmidt NW, Lai GH, Abbamonte P, Wong GC. Dynamics of confined water reconstructed from inelastic x-ray scattering measurements of bulk response functions. Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Mar; 85(3 Pt 1):031501. PMID: 22587097.
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    28. Mishra A, Lai GH, Schmidt NW, Sun VZ, Rodriguez AR, Tong R, Tang L, Cheng J, Deming TJ, Kamei DT, Wong GC. Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16883-8. PMID: 21969533; PMCID: PMC3193208.
    29. Schmidt NW, Mishra A, Lai GH, Davis M, Sanders LK, Tran D, Garcia A, Tai KP, McCray PB, Ouellette AJ, Selsted ME, Wong GC. Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc. 2011 May 04; 133(17):6720-7. PMID: 21473577; PMCID: PMC3090259.
    30. Schmidt NW, Harty JT. Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization. J Immunol. 2011 Apr 01; 186(7):3836-40. PMID: 21357257; PMCID: PMC3074438.
    31. Mishra A, Tai KP, Schmidt NW, Ouellette AJ, Wong GC. Small-angle X-ray scattering studies of peptide-lipid interactions using the mouse paneth cell a-defensin cryptdin-4. Methods Enzymol. 2011; 492:127-49. PMID: 21333790.
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    32. Abbamonte P, Wong GC, Cahill DG, Reed JP, Coridan RH, Schmidt NW, Lai GH, Joe YI, Casa D. Ultrafast imaging and the phase problem for inelastic X-ray scattering. Adv Mater. 2010 Mar 12; 22(10):1141-7. PMID: 20401938.
      View in: PubMed
    33. Mylon SE, Rinciog CI, Schmidt N, Gutierrez L, Wong GC, Nguyen TH. Influence of salts and natural organic matter on the stability of bacteriophage MS2. Langmuir. 2010 Jan 19; 26(2):1035-42. PMID: 19775143.
      View in: PubMed
    34. Coridan RH, Schmidt NW, Lai GH, Godawat R, Krisch M, Garde S, Abbamonte P, Wong GC. Hydration dynamics at femtosecond time scales and angstrom length scales from inelastic x-ray scattering. Phys Rev Lett. 2009 Dec 04; 103(23):237402. PMID: 20366171.
      View in: PubMed
    35. Schmidt N, Mishra A, Lai GH, Wong GC. Arginine-rich cell-penetrating peptides. FEBS Lett. 2010 May 03; 584(9):1806-13. PMID: 19925791.
      View in: PubMed
    36. Stark LR, Kruger PB, Rucker FJ, Swanson WH, Schmidt N, Hardy C, Rutman H, Borgovan T, Burke S, Badar M, Shah R. Potential signal to accommodation from the Stiles-Crawford effect and ocular monochromatic aberrations. J Mod Opt. 2009 Nov; 56(20):2203-2216. PMID: 20835401.
      View in: PubMed
    37. Coridan RH, Schmidt NW, Lai GH, Wong GC. Hydration structures near finite-sized nanoscopic objects reconstructed using inelastic x-ray scattering measurements. J Phys Condens Matter. 2009 Oct 21; 21(42):424115. PMID: 21715850.
      View in: PubMed
    38. Yang L, Gordon VD, Trinkle DR, Schmidt NW, Davis MA, DeVries C, Som A, Cronan JE, Tew GN, Wong GC. Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20595-600. PMID: 19106303; PMCID: PMC2634941.
    39. Kruger PB, Rucker FJ, Hu C, Rutman H, Schmidt NW, Roditis V. Accommodation with and without short-wavelength-sensitive cones and chromatic aberration. Vision Res. 2005 May; 45(10):1265-74. PMID: 15733959.
      View in: PubMed
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