Nathaniel Huebsch

TitleEmployee of Affiliated Org.
InstitutionUniversity of California San Francisco
DepartmentGladstone Institutes
Address1650 Owens St
San Francisco CA 94107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hoang P, Huebsch N, Bang SH, Siemons BA, Conklin BR, Healy KE, Ma Z, Jacquir S. Quantitatively Characterizing Drug-Induced Arrhythmic Contractile Motions of Human Stem Cell-Derived Cardiomyocytes. Biotechnol Bioeng. 2018 Apr 16. PMID: 29663322.
      View in: PubMed
    2. Cipitria A, Boettcher K, Schoenhals S, Garske DS, Schmidt-Bleek K, Ellinghaus A, Dienelt A, Peters A, Mehta M, Madl CM, Huebsch N, Mooney DJ, Duda GN. In-situ tissue regeneration through SDF-1a driven cell recruitment and stiffness-mediated bone regeneration in a critical-sized segmental femoral defect. Acta Biomater. 2017 Sep 15; 60:50-63. PMID: 28739546.
      View in: PubMed
    3. Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR. Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses. Sci Rep. 2016 Apr 20; 6:24726. PMID: 27095412; PMCID: PMC4837370.
    4. Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR. CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. 2016 Apr 07; 18(4):541-53. PMID: 26971820; PMCID: PMC4830697 [Available on 04/07/17].
    5. Chaudhuri O, Gu L, Klumpers D, Darnell M, Bencherif SA, Weaver JC, Huebsch N, Lee HP, Lippens E, Duda GN, Mooney DJ. Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat Mater. 2016 Mar; 15(3):326-34. PMID: 26618884; PMCID: PMC4767627.
    6. Huebsch N, Lippens E, Lee K, Mehta M, Koshy ST, Darnell MC, Desai RM, Madl CM, Xu M, Zhao X, Chaudhuri O, Verbeke C, Kim WS, Alim K, Mammoto A, Ingber DE, Duda GN, Mooney DJ. Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation. Nat Mater. 2015 Dec; 14(12):1269-77. PMID: 26366848; PMCID: PMC4654683.
    7. Ma Z, Wang J, Loskill P, Huebsch N, Koo S, Svedlund FL, Marks NC, Hua EW, Grigoropoulos CP, Conklin BR, Healy KE. Self-organizing human cardiac microchambers mediated by geometric confinement. Nat Commun. 2015 Jul 14; 6:7413. PMID: 26172574; PMCID: PMC4503387.
    8. Mathur A, Loskill P, Shao K, Huebsch N, Hong S, Marcus SG, Marks N, Mandegar M, Conklin BR, Lee LP, Healy KE. Human iPSC-based cardiac microphysiological system for drug screening applications. Sci Rep. 2015 Mar 09; 5:8883. PMID: 25748532; PMCID: PMC4352848.
    9. Chaudhuri O, Gu L, Darnell M, Klumpers D, Bencherif SA, Weaver JC, Huebsch N, Mooney DJ. Substrate stress relaxation regulates cell spreading. Nat Commun. 2015 Feb 19; 6:6364. PMID: 25695512; PMCID: PMC4518451.
    10. Huebsch N, Loskill P, Mandegar MA, Marks NC, Sheehan AS, Ma Z, Mathur A, Nguyen TN, Yoo JC, Judge LM, Spencer CI, Chukka AC, Russell CR, So PL, Conklin BR, Healy KE. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales. Tissue Eng Part C Methods. 2015 May; 21(5):467-79. PMID: 25333967; PMCID: PMC4410286.
    11. Huebsch N, Kearney CJ, Zhao X, Kim J, Cezar CA, Suo Z, Mooney DJ. Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9762-7. PMID: 24961369; PMCID: PMC4103344.
    12. Ma Z, Koo S, Finnegan MA, Loskill P, Huebsch N, Marks NC, Conklin BR, Grigoropoulos CP, Healy KE. Three-dimensional filamentous human diseased cardiac tissue model. Biomaterials. 2014 Feb; 35(5):1367-77. PMID: 24268663; PMCID: PMC3900500.
    13. Uhrig BA, Boerckel JD, Willett NJ, Li MT, Huebsch N, Guldberg RE. Recovery from hind limb ischemia enhances rhBMP-2-mediated segmental bone defect repair in a rat composite injury model. Bone. 2013 Aug; 55(2):410-7. PMID: 23664918.
      View in: PubMed
    14. Willett NJ, Li MT, Uhrig BA, Boerckel JD, Huebsch N, Lundgren TL, Warren GL, Guldberg RE. Attenuated human bone morphogenetic protein-2-mediated bone regeneration in a rat model of composite bone and muscle injury. Tissue Eng Part C Methods. 2013 Apr; 19(4):316-25. PMID: 22992043; PMCID: PMC3583252.
    15. Uhrig BA, Clements IP, Boerckel JD, Huebsch N, Bellamkonda RV, Guldberg RE. Characterization of a composite injury model of severe lower limb bone and nerve trauma. J Tissue Eng Regen Med. 2014 Jun; 8(6):432-41. PMID: 22689452.
      View in: PubMed
    16. Kim WS, Mooney DJ, Arany PR, Lee K, Huebsch N, Kim J. Adipose tissue engineering using injectable, oxidized alginate hydrogels. Tissue Eng Part A. 2012 Apr; 18(7-8):737-43. PMID: 22011105.
      View in: PubMed
    17. Boerckel JD, Uhrig BA, Willett NJ, Huebsch N, Guldberg RE. Mechanical regulation of vascular growth and tissue regeneration in vivo. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):E674-80. PMID: 21876139; PMCID: PMC3174614.
    18. Kolambkar YM, Boerckel JD, Dupont KM, Bajin M, Huebsch N, Mooney DJ, Hutmacher DW, Guldberg RE. Spatiotemporal delivery of bone morphogenetic protein enhances functional repair of segmental bone defects. Bone. 2011 Sep; 49(3):485-92. PMID: 21621027; PMCID: PMC3143222.
    19. Bencherif SA, Guillemot F, Huebsch N, Edwards DA, Mooney DJ. [Cell-traction mediated configuration of the cell/extracellular-matrix interface plays a key role in stem cell fate]. Med Sci (Paris). 2011 Jan; 27(1):19-21. PMID: 21299954.
      View in: PubMed
    20. Zhao X, Kim J, Cezar CA, Huebsch N, Lee K, Bouhadir K, Mooney DJ. Active scaffolds for on-demand drug and cell delivery. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):67-72. PMID: 21149682; PMCID: PMC3017202.
    21. Kolambkar YM, Dupont KM, Boerckel JD, Huebsch N, Mooney DJ, Hutmacher DW, Guldberg RE. An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. Biomaterials. 2011 Jan; 32(1):65-74. PMID: 20864165; PMCID: PMC3013370.
    22. Huebsch N, Arany PR, Mao AS, Shvartsman D, Ali OA, Bencherif SA, Rivera-Feliciano J, Mooney DJ. Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater. 2010 Jun; 9(6):518-26. PMID: 20418863; PMCID: PMC2919753.
    23. Zhao X, Huebsch N, Mooney DJ, Suo Z. Stress-relaxation behavior in gels with ionic and covalent crosslinks. J Appl Phys. 2010 Mar 15; 107(6):63509. PMID: 21464912.
      View in: PubMed
    24. Chueh BH, Zheng Y, Torisawa YS, Hsiao AY, Ge C, Hsiong S, Huebsch N, Franceschi R, Mooney DJ, Takayama S. Patterning alginate hydrogels using light-directed release of caged calcium in a microfluidic device. Biomed Microdevices. 2010 Feb; 12(1):145-51. PMID: 19830565; PMCID: PMC2825700.
    25. Huebsch N, Mooney DJ. Inspiration and application in the evolution of biomaterials. Nature. 2009 Nov 26; 462(7272):426-32. PMID: 19940912; PMCID: PMC2848528.
    26. Hsiong SX, Boontheekul T, Huebsch N, Mooney DJ. Cyclic arginine-glycine-aspartate peptides enhance three-dimensional stem cell osteogenic differentiation. Tissue Eng Part A. 2009 Feb; 15(2):263-72. PMID: 18783323; PMCID: PMC2774232.
    27. Ali OA, Huebsch N, Cao L, Dranoff G, Mooney DJ. Infection-mimicking materials to program dendritic cells in situ. Nat Mater. 2009 Feb; 8(2):151-8. PMID: 19136947; PMCID: PMC2684978.
    28. Hsiong SX, Huebsch N, Fischbach C, Kong HJ, Mooney DJ. Integrin-adhesion ligand bond formation of preosteoblasts and stem cells in three-dimensional RGD presenting matrices. Biomacromolecules. 2008 Jul; 9(7):1843-51. PMID: 18540674; PMCID: PMC2853778.
    29. Kong HJ, Kim CJ, Huebsch N, Weitz D, Mooney DJ. Noninvasive probing of the spatial organization of polymer chains in hydrogels using fluorescence resonance energy transfer (FRET). J Am Chem Soc. 2007 Apr 18; 129(15):4518-9. PMID: 17381090.
      View in: PubMed
    30. Huebsch N, Mooney DJ. Fluorescent resonance energy transfer: A tool for probing molecular cell-biomaterial interactions in three dimensions. Biomaterials. 2007 May; 28(15):2424-37. PMID: 17270268; PMCID: PMC2176075.
    31. Huebsch N, Gilbert M, Healy KE. Analysis of sterilization protocols for peptide-modified hydrogels. J Biomed Mater Res B Appl Biomater. 2005 Jul; 74(1):440-7. PMID: 15889434.
      View in: PubMed