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Neelanjan Bose, PhD

Title(s)Emery Pharm-Assoc. Dir Chemist, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Phone415-209-6768
ORCID ORCID Icon0000-0002-3817-4757 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Cornell University, Ithaca, NY, USAPhD01/2014Analytical Chemistry and Chemical Biology
    Indian Institute of Technology, Kanpur, IndiaMS05/2008Chemistry
    Presidency College, University of Calcutta, Kolkata, IndiaBS07/2006Chemistry

    Collapse Overview 
    Collapse Overview
    I am an experienced biomedical scientist in the field of bioanalytical chemistry and chemical biology working in close collaboration with chemists, biologists, and clinical investigators. I played an instrumental role in advancing a drug from in vitro/in vivo model systems to 2 currently active clinical trials for a rare genetic disorder called cystinuria. Serve as an Editor at Bio-protocol and Peer-reviewer for several dozen high-profile journals. In my personal life, I am a prolific reader and love to cook.

    In my career, I have taken the lead in managing fast paced, cross-functional research projects, which resulted in 17 high-profile publications in premiere journals like Nature Medicine, Nature Immunology, Cell Metabolism; 1 provisional patent filing; and securing $2.5M+ in research funding from the FDA and the NIH. These collaborations have helped me develop into a confident and creative researcher, capable of independent thinking, execution, and troubleshooting.

    Apart from research, I am a skilled mentor, and took the lead in establishing, budget designing, and managing a Bioanalytics core facility at UCSF, offering customized technical, software, and training support to the UC community.

    Disease areas: Diabetes and associated complications, obesity, neurodegenerative disease (Parkinson’s disease), kidney stone diseases, parasitic nematode infections.

    Expertise: Bioanalytical method/assay design and development, HPLC (RP, HILIC, SEC, IEC and HIC modes), GC, mass spectrometry (MS, MS/MS), small molecule drug discovery, drug metabolism, pharmacokinetics, high-throughput screening (HTS), lead optimization, biomarker discovery, metabolomics, isotope dilution, 2D NMR, chromatography, spectroscopy (absorbance, fluorescence, FTIR), preclinical models, chemical synthesis, and project management/organization.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P. A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. PLoS Genet. 2019 Aug; 15(8):e1008318. PMID: 31415568.
      View in: PubMed
    2. Chaudhuri J, Bains Y, Guha S, Kahn A, Hall D, Bose N, Gugliucci A, Kapahi P. The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality. Cell Metab. 2018 09 04; 28(3):337-352. PMID: 30184484.
      View in: PubMed
    3. Falcke JM, Bose N, Artyukhin AB, Rödelsperger C, Markov GV, Yim JJ, Grimm D, Claassen MH, Panda O, Baccile JA, Zhang YK, Le HH, Jolic D, Schroeder FC, Sommer RJ. Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis. Cell Chem Biol. 2018 06 21; 25(6):787-796.e12. PMID: 29779955.
      View in: PubMed
    4. Liu Z, Kariya MJ, Chute CD, Pribadi AK, Leinwand SG, Tong A, Curran KP, Bose N, Schroeder FC, Srinivasan J, Chalasani SH. Predator-secreted sulfolipids induce defensive responses in C. elegans. Nat Commun. 2018 03 19; 9(1):1128. PMID: 29555902.
      View in: PubMed
    5. Bose N, Zee T, Kapahi P, Stoller ML. Mass Spectrometry-based in vitro Assay to Identify Drugs that Influence Cystine Solubility. Bio Protoc. 2017 Jul 20; 7(14). PMID: 28868331.
      View in: PubMed
    6. Tiffany Zee, Neelanjan Bose, Jarcy Zee, Jennifer Beck, See Yang, Jaspreet Parihar, Min Yang, Sruthi Damodar, David Hall, Monique O'Leary, Arvind Ramanathan, Roy Gerona, David Killilea, Thomas Chi, Jay Tischfield, Amrik Sahota, Arnold Kahn, Pankaj Kapahi, Marshall Stoller. MP12-12 ?-LIPOIC ACID SUPPRESSES CYSTINE STONE FORMATION IN A GENETIC MOUSE MODEL OF CYSTINURIA. The Journal of Urology. 2017 Apr 1; 197(4):e149.
      View in: Publisher Site
    7. Zee T, Bose N, Zee J, Beck JN, Yang S, Parihar J, Yang M, Damodar S, Hall D, O'Leary MN, Ramanathan A, Gerona RR, Killilea DW, Chi T, Tischfield J, Sahota A, Kahn A, Stoller ML, Kapahi P. a-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nat Med. 2017 Mar; 23(3):288-290. PMID: 28165480.
      View in: PubMed
    8. Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, Peiris TH, Chamoli M, Le CH, Liu J, Lithgow GJ, Ramanathan A, Xu XZS, Kapahi P. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive a-Dicarbonyl Detoxification. Curr Biol. 2016 11 21; 26(22):3014-3025. PMID: 27773573.
      View in: PubMed
    9. Chaudhuri J, Bose N, Tandonnet S, Adams S, Zuco G, Kache V, Parihar M, von Reuss SH, Schroeder FC, Pires-daSilva A. Erratum: Mating dynamics in a nematode with three sexes and its evolutionary implications. Sci Rep. 2016 Apr 07; 6:23852. PMID: 27055251.
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    10. Narayan A, Venkatachalam V, Durak O, Reilly DK, Bose N, Schroeder FC, Samuel AD, Srinivasan J, Sternberg PW. Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1392-401. PMID: 26903633.
      View in: PubMed
    11. Chaudhuri J, Bose N, Tandonnet S, Adams S, Zuco G, Kache V, Parihar M, von Reuss SH, Schroeder FC, Pires-daSilva A. Mating dynamics in a nematode with three sexes and its evolutionary implications. Sci Rep. 2015 Dec 03; 5:17676. PMID: 26631423.
      View in: PubMed
    12. Katewa SD, Akagi K, Bose N, Rakshit K, Camarella T, Zheng X, Hall D, Davis S, Nelson CS, Brem RB, Ramanathan A, Sehgal A, Giebultowicz JM, Kapahi P. Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila. Cell Metab. 2016 Jan 12; 23(1):143-54. PMID: 26626459.
      View in: PubMed
    13. Chi T, Kim MS, Lang S, Bose N, Kahn A, Flechner L, Blaschko SD, Zee T, Muteliefu G, Bond N, Kolipinski M, Fakra SC, Mandel N, Miller J, Ramanathan A, Killilea DW, Brückner K, Kapahi P, Stoller ML. A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. PLoS One. 2015; 10(5):e0124150. PMID: 25970330.
      View in: PubMed
    14. Yim JJ, Bose N, Meyer JM, Sommer RJ, Schroeder FC. Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks. Org Lett. 2015 Apr 03; 17(7):1648-51. PMID: 25782998.
      View in: PubMed
    15. Zugasti O, Bose N, Squiban B, Belougne J, Kurz CL, Schroeder FC, Pujol N, Ewbank JJ. Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans. Nat Immunol. 2014 Sep; 15(9):833-8. PMID: 25086774.
      View in: PubMed
    16. Bose N, Meyer JM, Yim JJ, Mayer MG, Markov GV, Ogawa A, Schroeder FC, Sommer RJ. Natural variation in dauer pheromone production and sensing supports intraspecific competition in nematodes. Curr Biol. 2014 Jul 07; 24(13):1536-41. PMID: 24980503.
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    17. Mahanti P, Bose N, Bethke A, Judkins JC, Wollam J, Dumas KJ, Zimmerman AM, Campbell SL, Hu PJ, Antebi A, Schroeder FC. Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Cell Metab. 2014 Jan 07; 19(1):73-83. PMID: 24411940.
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    18. Artyukhin AB, Yim JJ, Srinivasan J, Izrayelit Y, Bose N, von Reuss SH, Jo Y, Jordan JM, Baugh LR, Cheong M, Sternberg PW, Avery L, Schroeder FC. Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in Caenorhabditis elegans. J Biol Chem. 2013 Jun 28; 288(26):18778-83. PMID: 23689506.
      View in: PubMed
    19. Neelanjan Bose, Akira Ogawa, Stephan H. von Reuss, Joshua J. Yim, Erik J. Ragsdale, Ralf J. Sommer, Frank C. Schroeder. Complex Small-Molecule Architectures Regulate Phenotypic Plasticity in a Nematode . Angewandte Chemie. 2012 Dec 7; 124(50):12606-12611.
      View in: Publisher Site
    20. Izrayelit Y, Robinette SL, Bose N, von Reuss SH, Schroeder FC. 2D NMR-based metabolomics uncovers interactions between conserved biochemical pathways in the model organism Caenorhabditis elegans. ACS Chem Biol. 2013 Feb 15; 8(2):314-9. PMID: 23163760.
      View in: PubMed
    21. Bose N, Ogawa A, von Reuss SH, Yim JJ, Ragsdale EJ, Sommer RJ, Schroeder FC. Complex small-molecule architectures regulate phenotypic plasticity in a nematode. Angew Chem Int Ed Engl. 2012 Dec 07; 51(50):12438-43. PMID: 23161728.
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    22. von Reuss SH, Bose N, Srinivasan J, Yim JJ, Judkins JC, Sternberg PW, Schroeder FC. Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans. J Am Chem Soc. 2012 Jan 25; 134(3):1817-24. PMID: 22239548.
      View in: PubMed
    23. Srinivasan J, von Reuss SH, Bose N, Zaslaver A, Mahanti P, Ho MC, O'Doherty OG, Edison AS, Sternberg PW, Schroeder FC. A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans. PLoS Biol. 2012 Jan; 10(1):e1001237. PMID: 22253572.
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