Neelroop Parikshak, MD, PhD

TitleResident Physician
InstitutionUniversity of California San Francisco
Address505 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    UCLA, Los Angeles, CAM.D.06/2017Medicine
    UCLA, Los Angeles, CAPh.D.06/2015Neuroscience
    Rice University, Houston, TXB.A.05/2007Mathematics, Biochemistry & Cell Biology

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    Collapse Overview
    I am a physician-scientist completing my clinical training in Neurology at UCSF. I have a background in both biology and mathematics which has led me to pursue practical medical questions with rigorous, data-driven approaches.

    I have over a decade of experience working with both academia and industry. My work spans human neuroimaging, neurophysiology, and disease genetics (see publications below). I also have several years of experience consulting for biotech and health informatics companies on the design of high-yield high-throughput experiments, statistical analysis for predictive modeling, and technology development.

    My clinical interests include movement disorders, epilepsy, neurodegeneration. My basic science research applies high-throughput biology and bioinformatics methods to elucidate how genetic variation influences human cognition and behavior in health and disease. My clinical research interests include big data in healthcare and the development of quantitative approaches to facilitate precision medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    Transcriptional Regulators in Normal Human Brain Development and Autism
    NIH/NIMH F30MH099886Dec 3, 2012 - Jun 2, 2015
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gandal MJ, Haney JR, Parikshak N, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science. 2018 02 09; 359(6376):693-697. PMID: 29439242.
      View in: PubMed
    2. Parikshak N, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, Ubieta LT, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH. Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. 2016 12 15; 540(7633):423-427. PMID: 27919067.
      View in: PubMed
    3. Sun W, Poschmann J, Cruz-Herrera Del Rosario R, Parikshak N, Hajan HS, Kumar V, Ramasamy R, Belgard TG, Elanggovan B, Wong CCY, Mill J, Geschwind DH, Prabhakar S. Histone Acetylome-wide Association Study of Autism Spectrum Disorder. Cell. 2016 11 17; 167(5):1385-1397.e11. PMID: 27863250.
      View in: PubMed
    4. Gandal MJ, Leppa V, Won H, Parikshak N, Geschwind DH. The road to precision psychiatry: translating genetics into disease mechanisms. Nat Neurosci. 2016 10 26; 19(11):1397-1407. PMID: 27786179.
      View in: PubMed
    5. Won H, de la Torre-Ubieta L, Stein JL, Parikshak N, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH. Chromosome conformation elucidates regulatory relationships in developing human brain. Nature. 2016 10 27; 538(7626):523-527. PMID: 27760116.
      View in: PubMed
    6. Wu YE, Parikshak N, Belgard TG, Geschwind DH. Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder. Nat Neurosci. 2016 11; 19(11):1463-1476. PMID: 27571009.
      View in: PubMed
    7. Werling DM, Parikshak N, Geschwind DH. Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders. Nat Commun. 2016 Feb 19; 7:10717. PMID: 26892004; PMCID: PMC4762891.
    8. Lee JA, Damianov A, Lin CH, Fontes M, Parikshak N, Anderson ES, Geschwind DH, Black DL, Martin KC. Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes. Neuron. 2016 Jan 06; 89(1):113-28. PMID: 26687839; PMCID: PMC4858412 [Available on 01/06/17].
    9. The PsychENCODE project. Nat Neurosci. 2015 Dec; 18(12):1707-12. PMID: 26605881.
      View in: PubMed
    10. Suthana NA, Parikshak N, Ekstrom AD, Ison MJ, Knowlton BJ, Bookheimer SY, Fried I. Specific responses of human hippocampal neurons are associated with better memory. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10503-8. PMID: 26240357; PMCID: PMC4547223.
    11. Parikshak N, Gandal MJ, Geschwind DH. Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders. Nat Rev Genet. 2015 Aug; 16(8):441-58. PMID: 26149713; PMCID: PMC4699316.
    12. Bakken TE, Miller JA, Luo R, Bernard A, Bennett JL, Lee CK, Bertagnolli D, Parikshak N, Smith KA, Sunkin SM, Amaral DG, Geschwind DH, Lein ES. Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. Hum Mol Genet. 2015 Aug 01; 24(15):4327-39. PMID: 25954031; PMCID: PMC4492396.
    13. Irimia M, Weatheritt RJ, Ellis JD, Parikshak N, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallières M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, Geschwind DH, Blencowe BJ. A highly conserved program of neuronal microexons is misregulated in autistic brains. Cell. 2014 Dec 18; 159(7):1511-23. PMID: 25525873; PMCID: PMC4390143 [Available on 12/18/15].
    14. Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak N, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH. A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron. 2014 Jul 02; 83(1):69-86. PMID: 24991955; PMCID: PMC4277209.
    15. Parikshak N, Luo R, Zhang A, Won H, Lowe JK, Chandran V, Horvath S, Geschwind DH. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell. 2013 Nov 21; 155(5):1008-21. PMID: 24267887; PMCID: PMC3934107.
    16. Stein JL, Parikshak N, Geschwind DH. Rare inherited variation in autism: beginning to see the forest and a few trees. Neuron. 2013 Jan 23; 77(2):209-11. PMID: 23352155; PMCID: PMC3691080.
    17. Fogel BL, Wexler E, Wahnich A, Friedrich T, Vijayendran C, Gao F, Parikshak N, Konopka G, Geschwind DH. RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Hum Mol Genet. 2012 Oct 01; 21(19):4171-86. PMID: 22730494; PMCID: PMC3441119.
    18. Sanders SJ, Murtha MT, Gupta AR, Murdoch JD, Raubeson MJ, Willsey AJ, Ercan-Sencicek AG, DiLullo NM, Parikshak N, Stein JL, Walker MF, Ober GT, Teran NA, Song Y, El-Fishawy P, Murtha RC, Choi M, Overton JD, Bjornson RD, Carriero NJ, Meyer KA, Bilguvar K, Mane SM, Sestan N, Lifton RP, Günel M, Roeder K, Geschwind DH, Devlin B, State MW. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature. 2012 Apr 04; 485(7397):237-41. PMID: 22495306; PMCID: PMC3667984.
    19. Lu PH, Thompson PM, Leow A, Lee GJ, Lee A, Yanovsky I, Parikshak N, Khoo T, Wu S, Geschwind D, Bartzokis G. Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study. J Alzheimers Dis. 2011; 23(3):433-42. PMID: 21098974; PMCID: PMC3107252.
    20. Raji CA, Ho AJ, Parikshak N, Becker JT, Lopez OL, Kuller LH, Hua X, Leow AD, Toga AW, Thompson PM. Brain structure and obesity. Hum Brain Mapp. 2010 Mar; 31(3):353-64. PMID: 19662657; PMCID: PMC2826530.
    21. Aganj I, Sapiro G, Parikshak N, Madsen SK, Thompson PM. Measurement of cortical thickness from MRI by minimum line integrals on soft-classified tissue. Hum Brain Mapp. 2009 Oct; 30(10):3188-99. PMID: 19219850; PMCID: PMC2903209.
    22. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM. Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Hum Brain Mapp. 2009 Sep; 30(9):2766-88. PMID: 19172649; PMCID: PMC2733926.
    23. Leow AD, Yanovsky I, Parikshak N, Hua X, Lee S, Toga AW, Jack CR, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Borowski B, Shaw LM, Trojanowski JQ, Fleisher AS, Harvey D, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition. Neuroimage. 2009 Apr 15; 45(3):645-55. PMID: 19280686; PMCID: PMC2696624.
    24. Chou YY, Leporé N, Avedissian C, Madsen SK, Parikshak N, Hua X, Shaw LM, Trojanowski JQ, Weiner MW, Toga AW, Thompson PM. Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controls. Neuroimage. 2009 Jun; 46(2):394-410. PMID: 19236926; PMCID: PMC2696357.
    25. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM. Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Neuroimage. 2009 Mar; 45(1 Suppl):S3-15. PMID: 19041724; PMCID: PMC2733354.
    26. Hua X, Leow AD, Parikshak N, Lee S, Chiang MC, Toga AW, Jack CR, Weiner MW, Thompson PM. Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects. Neuroimage. 2008 Nov 15; 43(3):458-69. PMID: 18691658; PMCID: PMC3197851.
    27. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Weiner MW, Thompson PM. Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controls. Neuroimage. 2008 Oct 15; 43(1):59-68. PMID: 18675918; PMCID: PMC2624575.
    28. Aganj I, Sapiro G, Parikshak N, Madsen SK, Thompson PM. SEGMENTATION-FREE MEASURING OF CORTICAL THICKNESS FROM MRI. Proc IEEE Int Symp Biomed Imaging. 2008 May; 2008:1625-1628. PMID: 25741407.
      View in: PubMed
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