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Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis. Cell Host Microbe. 2023 Sep 20.
Kehrer T, Cupic A, Ye C, Yildiz S, Bouhaddou M, Crossland NA, Barrall EA, Cohen P, Tseng A, Çagatay T, Rathnasinghe R, Flores D, Jangra S, Alam F, Mena I, Aslam S, Saqi A, Rutkowska M, Ummadi MR, Pisanelli G, Richardson RB, Veit EC, Fabius JM, Soucheray M, Polacco BJ, Ak B, Marin A, Evans MJ, Swaney DL, Gonzalez-Reiche AS, Sordillo EM, van Bakel H, Simon V, Zuliani-Alvarez L, Fontoura BMA, Rosenberg BR, Krogan NJ, Martinez-Sobrido L, García-Sastre A, Miorin L. PMID: 37738983.
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SARS-CoV-2 variants evolve convergent strategies to remodel the host response. Cell. 2023 Sep 19.
Bouhaddou M, Reuschl AK, Polacco BJ, Thorne LG, Ummadi MR, Ye C, Rosales R, Pelin A, Batra J, Jang GM, Xu J, Moen JM, Richards AL, Zhou Y, Harjai B, Stevenson E, Rojc A, Ragazzini R, Whelan MVX, Furnon W, De Lorenzo G, Cowton V, Syed AM, Ciling A, Deutsch N, Pirak D, Dowgier G, Mesner D, Turner JL, McGovern BL, Rodriguez ML, Leiva-Rebollo R, Dunham AS, Zhong X, Eckhardt M, Fossati A, Liotta NF, Kehrer T, Cupic A, Rutkowska M, Mena I, Aslam S, Hoffert A, Foussard H, Olwal CO, Huang W, Zwaka T, Pham J, Lyons M, Donohue L, Griffin A, Nugent R, Holden K, Deans R, Aviles P, Lopez-Martin JA, Jimeno JM, Obernier K, Fabius JM, Soucheray M, Hüttenhain R, Jungreis I, Kellis M, Echeverria I, Verba K, Bonfanti P, Beltrao P, Sharan R, Doudna JA, Martinez-Sobrido L, Patel AH, Palmarini M, Miorin L, White K, Swaney DL, Garcia-Sastre A, Jolly C, Zuliani-Alvarez L, Towers GJ, Krogan NJ. PMID: 37738970.
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A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo. PLoS Pathog. 2023 Aug 31; 19(8):e1011614.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, McCavitt-Malvido M, O'Leary PC, Jogalekar MP, Diolaiti ME, Kimmerly GR, Tsou CL, Gascon R, Montano M, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. PMID: 37651466.
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1 Fields:
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HumansAnimalsCells
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Next-generation proteomics for quantitative Jumbophage-bacteria interaction mapping. Nat Commun. 2023 Aug 24; 14(1):5156.
Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL. PMID: 37620325; PMCID: PMC10449902.
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Translation:
Cells
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Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila. bioRxiv. 2023 Aug 03.
Steinbach AM, Bhadkamkar VL, Jimenez-Morales D, Stevenson E, Jang GM, Krogan NJ, Swaney DL, Mukherjee S. PMID: 37577546; PMCID: PMC10418220.
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Functional analysis of a common BAG3 allele associated with protection from heart failure. Nature Cardiovascular Research. 2023; 2(6):615–628.
Perez-Bermejo JA, Judge LM, Jensen CL, Wu K, Watry HL, Truong A, Ho JJ, Carter M, Runyon WV, Kaake RM, Pulido EH, Mandegar MA, Swaney DL, So P-L, Krogan NJ & Conklin BR. View Publication.
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Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens. PLoS Pathog. 2023 06; 19(6):e1011088.
Morrison HM, Craft J, Rivera-Lugo R, Johnson JR, Golovkine GR, Bell SL, Dodd CE, Van Dis E, Beatty WL, Margolis SR, Repasy T, Shaker I, Lee AY, Vance RE, Stanley SA, Watson RO, Krogan NJ, Portnoy DA, Penn BH, Cox JS. PMID: 37352334; PMCID: PMC10325092.
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1 Fields:
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AnimalsCells
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Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun. 2023 06 19; 14(1):3543.
Torosyan H, Paul MD, Forget A, Lo M, Diwanji D, Pawlowski K, Krogan NJ, Jura N, Verba KA. PMID: 37336883; PMCID: PMC10279700.
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Cells
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Lessons learned for pandemic preparedness: A collaborative network is imperative. Cell Host Microbe. 2023 Jun 14; 31(6):843-846.
Fabius JM, Krogan NJ. PMID: 37321167; PMCID: PMC10265763.
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HumansCellsPHPublic Health
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Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol. 2023 07; 24(7):1173-1187.
Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora MDPS, Zamvil SS, Pico AR, Ryu JK, Krogan NJ, Akassoglou K. PMID: 37291385; PMCID: PMC10307624.
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1 Fields:
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AnimalsCells
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Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2220005120.
Gonzalez Lopez Ledesma MM, Costa Navarro G, Pallares HM, Paletta A, De Maio F, Iglesias NG, Gebhard L, Oviedo Rouco S, Ojeda DS, de Borba L, Giraldo M, Rajsbaum R, Ceballos A, Krogan NJ, Shah PS, Gamarnik AV. PMID: 37252973; PMCID: PMC10266027.
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HumansCells
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A multi-scale map of protein assemblies in the DNA damage response. Cell Syst. 2023 Jun 21; 14(6):447-463.e8.
Kratz A, Kim M, Kelly MR, Zheng F, Koczor CA, Li J, Ono K, Qin Y, Churas C, Chen J, Pillich RT, Park J, Modak M, Collier R, Licon K, Pratt D, Sobol RW, Krogan NJ, Ideker T. PMID: 37220749; PMCID: PMC10330685.
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1 Fields:
Translation:
Cells
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Network modeling suggests HIV infection phenocopies PI3K-AKT pathway mutations to enhance HPV-associated cervical cancer. Mol Omics. 2023 May 19.
Olwal CO, Fabius JM, Zuliani-Alvarez L, Eckhardt M, Kyei GB, Quashie PK, Krogan NJ, Bouhaddou M, Bediako Y. PMID: 37204043.
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HumansCells
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Current proteomics methods applicable to dissecting the DNA damage response. NAR Cancer. 2023 Jun; 5(2):zcad020.
Muralidharan M, Krogan NJ, Bouhaddou M, Kim M. PMID: 37213254; PMCID: PMC10198729.
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PubMed Mentions:
1
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A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo. bioRxiv. 2023 May 10.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, O'Leary PC, Jogalekar MP, McCavitt-Malvido M, Diolaiti ME, Kimmerly GR, Tsou CL, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. PMID: 37131711; PMCID: PMC10153184.
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An automated proximity proteomics pipeline for subcellular proteome and protein interaction mapping. bioRxiv. 2023 Apr 12.
Zhong X, Li Q, Polacco BJ, Patil T, DiBerto JF, Vartak R, Xu J, Marley A, Foussard H, Roth BL, Eckhardt M, Zastrow MV, Krogan NJ, Hüttenhain R. PMID: 37090610; PMCID: PMC10120663.
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Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP. Mol Cell Proteomics. 2023 05; 22(5):100541.
Cakir Z, Lord SJ, Zhou Y, Jang GM, Polacco BJ, Eckhardt M, Jimenez-Morales D, Newton BW, Orr AL, Johnson JR, da Cruz A, Mullins RD, Krogan NJ, Mahley RW, Swaney DL. PMID: 37019383; PMCID: PMC10196575.
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Translation:
AnimalsCells
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MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features. Res Sq. 2023 Mar 14.
Eaton C, Avalos L, Liu SJ, Casey-Clyde T, Bisignano P, Lucas CH, Stevenson E, Choudhury A, Vasudevan H, Magill S, Krogan N, Villanueva-Meyer J, Swaney D, Raleigh D. PMID: 36993679; PMCID: PMC10055685.
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Next-generation interaction proteomics for quantitative Jumbophage-bacteria interaction mapping. bioRxiv. 2023 Feb 23.
Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL. PMID: 36711836; PMCID: PMC9882154.
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Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat Struct Mol Biol. 2023 03; 30(3):296-308.
Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM. PMID: 36782050; PMCID: PMC10312659.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. bioRxiv. 2023 Jan 28.
Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM. PMID: 36747776; PMCID: PMC9900942.
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Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms. Elife. 2023 01 24; 12.
Chan GKL, Maisel S, Hwang YC, Pascual BC, Wolber RRB, Vu P, Patra KC, Bouhaddou M, Kenerson HL, Lim HC, Long D, Yeung RS, Sethupathy P, Swaney DL, Krogan NJ, Turnham RE, Riehle KJ, Scott JD, Bardeesy N, Gordan JD. PMID: 36692000; PMCID: PMC9925115.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Nuclear accumulation of host transcripts during Zika Virus Infection. PLoS Pathog. 2023 01; 19(1):e1011070.
Leon KE, Khalid MM, Flynn RA, Fontaine KA, Nguyen TT, Kumar GR, Simoneau CR, Tomar S, Jimenez-Morales D, Dunlap M, Kaye J, Shah PS, Finkbeiner S, Krogan NJ, Bertozzi C, Carette JE, Ott M. PMID: 36603024; PMCID: PMC9847913.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Workshop-based learning and networking: a scalable model for research capacity strengthening in low- and middle-income countries. Glob Health Action. 2022 12 31; 15(1):2062175.
Perier C, Nasinghe E, Charles I, Ssetaba LJ, Ahyong V, Bangs D, Beatty PR, Czudnochowski N, Diallo A, Dugan E, Fabius JM, Fong Baker H, Gardner J, Isaacs S, Joanah B, Kalantar K, Kateete D, Knight M, Krasilnikov M, Krogan NJ, Langelier C, Lee E, Li LM, Licht D, Lien K, Lyons Z, Mboowa G, Mwebaza I, Mwesigwa S, Nalwadda G, Nichols R, Penaranda ME, Petnic S, Phelps M, Popper SJ, Rape M, Reingold A, Robbins R, Rosenberg OS, Savage DF, Schildhauer S, Settles ML, Sserwadda I, Stanley S, Tato CM, Tsitsiklis A, Van Dis E, Vanaerschot M, Vinden J, Cox JS, Joloba ML, Schaletzky J. PMID: 35730550; PMCID: PMC9225690.
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Humans
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How can systems approaches help us understand and treat infectious disease? Cell Syst. 2022 12 21; 13(12):945-949.
Kuchina A, Yang J, Aldridge B, Janes KA, Subramanian N, Krogan NJ, Bouhaddou M, Einav S, Papin J, Germain RN. PMID: 36549272.
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Humans
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Quantitative proteomic analysis reveals apoE4-dependent phosphorylation of the actin regulating protein VASP. Alzheimer's & Dementia. 2022 Dec 20; 18(S3).
Cakir CZ, Polacco PB, Krogan KN, Mahley MR, Swaney SD. .
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Abstract B016: Inhibition of KRASG12C in colon cancer illustrates a link between beta-catenin, WNK, and the GID complex. Cancer Research. 2022 Dec 1; 82(23_Supplement_1):b016-b016.
Nayak NK, Hwang HY, Wang WL, Swaney SD, Krogan KN, Gordan GJ. .
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Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2. Cancer Res. 2022 11 02; 82(21):3950-3961.
O'Leary PC, Chen H, Doruk YU, Williamson T, Polacco B, McNeal AS, Shenoy T, Kale N, Carnevale J, Stevenson E, Quigley DA, Chou J, Feng FY, Swaney DL, Krogan NJ, Kim M, Diolaiti ME, Ashworth A. PMID: 36273492; PMCID: PMC9633439.
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2 Fields:
Translation:
HumansCells
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A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans. Genetics. 2022 11 01; 222(3).
Lu PYT, Kirlin AC, Aristizabal MJ, Brewis HT, Lévesque N, Setiaputra DT, Avvakumov N, Benschop JJ, Groot Koerkamp M, Holstege FCP, Krogan NJ, Yip CK, Côté J, Kobor MS. PMID: 36066422; PMCID: PMC9630986.
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HumansAnimalsCells
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Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis. bioRxiv. 2022 Oct 19.
Kehrer T, Cupic A, Ye C, Yildiz S, Bouhhadou M, Crossland NA, Barrall E, Cohen P, Tseng A, Çagatay T, Rathnasinghe R, Flores D, Jangra S, Alam F, Mena N, Aslam S, Saqi A, Marin A, Rutkowska M, Ummadi MR, Pisanelli G, Richardson RB, Veit EC, Fabius JM, Soucheray M, Polacco BJ, Evans MJ, Swaney DL, Gonzalez-Reiche AS, Sordillo EM, van Bakel H, Simon V, Zuliani-Alvarez L, Fontoura BMA, Rosenberg BR, Krogan NJ, Martinez-Sobrido L, García-Sastre A, Miorin L. PMID: 36299428; PMCID: PMC9603824.
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PubMed Mentions:
2
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Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication. Life Sci Alliance. 2023 01; 6(1).
Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JN, Dos Santos Souza C, Zhang S, Castelli L, Hautbergue G, Azzouz M, Gordon D, Krogan N, Ferraiuolo L, Snyder MP, Shaw PJ, Rehwinkel J, Cooper-Knock J. PMID: 36241425; PMCID: PMC9585911.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion. Aging Cell. 2022 Oct; 21(10):e13713.
Krause GJ, Diaz A, Jafari M, Khawaja RR, Agullo-Pascual E, Santiago-Fernández O, Richards AL, Chen KH, Dmitriev P, Sun Y, See SK, Abdelmohsen K, Mazan-Mamczarz K, Krogan NJ, Gorospe M, Swaney DL, Sidoli S, Bravo-Cordero JJ, Kampmann M, Cuervo AM. PMID: 36116133; PMCID: PMC9577956.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. PLoS Pathog. 2022 09; 18(9):e1010811.
Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Soveg FW, Gross JD, Krogan NJ, Jerome KR, Schilling B, Ott M, Verdin E. PMID: 36095012; PMCID: PMC9499238.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. 2022 10 05; 110(19):3154-3167.e7.
Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL. PMID: 36087581; PMCID: PMC9583076.
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18 Fields:
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Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3. Nat Commun. 2022 09 08; 13(1):5282.
Peters CE, Schulze-Gahmen U, Eckhardt M, Jang GM, Xu J, Pulido EH, Bardine C, Craik CS, Ott M, Gozani O, Verba KA, Hüttenhain R, Carette JE, Krogan NJ. PMID: 36075902; PMCID: PMC9453702.
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HumansCells
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CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir. mBio. 2022 10 26; 13(5):e0189122.
Packard TA, Schwarzer R, Herzig E, Rao D, Luo X, Egedal JH, Hsiao F, Widera M, Hultquist JF, Grimmett ZW, Messer RJ, Krogan NJ, Deeks SG, Roan NR, Dittmer U, Hasenkrug KJ, Greene WC. PMID: 36073812; PMCID: PMC9600577.
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2 Fields:
Translation:
AnimalsCells
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Editor's Note: Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Cancer Res. 2022 Sep 02; 82(17):3188.
Brand TM, Hartmann S, Bhola NE, Li H, Zeng Y, O'Keefe RA, Ranall MV, Bandyopadhyay S, Soucheray M, Krogan NJ, Kemp C, Duvvuri U, LaVallee T, Johnson DE, Ozbun MA, Bauman JE, Grandis JR. PMID: 36052495.
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Correction: Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Cancer Res. 2022 Sep 02; 82(17):3187.
Brand TM, Hartmann S, Bhola NE, Li H, Zeng Y, O'Keefe RA, Ranall MV, Bandyopadhyay S, Soucheray M, Krogan NJ, Kemp C, Duvvuri U, LaVallee T, Johnson DE, Ozbun MA, Bauman JE, Grandis JR. PMID: 36052496.
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Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Circulation. 2022 09 06; 146(10):770-787.
Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D. PMID: 35938400; PMCID: PMC9452483.
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HumansAnimalsCells
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A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor. Mol Cancer Ther. 2022 07 05; 21(7):1076-1089.
Chen H, Diolaiti ME, O'Leary PC, Rojc A, Krogan NJ, Kim M, Ashworth A. PMID: 35439318.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2. Cell Rep. 2022 07 19; 40(3):111088.
Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, Krogan N, Fujimori DG, Ott M. PMID: 35839775; PMCID: PMC9234021.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression. Development. 2022 06 01; 149(11).
Price JD, Lindtner S, Ypsilanti A, Binyameen F, Johnson JR, Newton BW, Krogan NJ, Rubenstein JLR. PMID: 35695185; PMCID: PMC9245191.
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1 Fields:
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Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 05; 54(5):649-659.
Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. PMID: 35534562; PMCID: PMC9374001.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling. Cell Rep. 2022 04 12; 39(2):110690.
Johnson JR, Crosby DC, Hultquist JF, Kurland AP, Adhikary P, Li D, Marlett J, Swann J, Hüttenhain R, Verschueren E, Johnson TL, Newton BW, Shales M, Simon VA, Beltrao P, Frankel AD, Marson A, Cox JS, Fregoso OI, Young JAT, Krogan NJ. PMID: 35417684; PMCID: PMC9429972.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Integrative structure determination of histones H3 and H4 using genetic interactions. FEBS J. 2023 05; 290(10):2565-2575.
Echeverria I, Braberg H, Krogan NJ, Sali A. PMID: 35298864; PMCID: PMC9481981.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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A functional map of HIV-host interactions in primary human T cells. Nat Commun. 2022 04 01; 13(1):1752.
Hiatt J, Hultquist JF, McGregor MJ, Bouhaddou M, Leenay RT, Simons LM, Young JM, Haas P, Roth TL, Tobin V, Wojcechowskyj JA, Woo JM, Rathore U, Cavero DA, Shifrut E, Nguyen TT, Haas KM, Malik HS, Doudna JA, May AP, Marson A, Krogan NJ. PMID: 35365639; PMCID: PMC8976027.
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15 Fields:
Translation:
HumansCells
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Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2. Nature. 2022 Apr; 604(7905):E14.
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hiatt J, Rosales R, McGovern BL, Jahun A, Fabius JM, White K, Goodfellow IG, Takeuchi Y, Bonfanti P, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Kellis M, Swaney DL, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. PMID: 35332335; PMCID: PMC8944406.
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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. J Cell Biol. 2022 04 04; 221(4).
Stormo AED, Shavarebi F, FitzGibbon M, Earley EM, Ahrendt H, Lum LS, Verschueren E, Swaney DL, Skibinski G, Ravisankar A, van Haren J, Davis EJ, Johnson JR, Von Dollen J, Balen C, Porath J, Crosio C, Mirescu C, Iaccarino C, Dauer WT, Nichols RJ, Wittmann T, Cox TC, Finkbeiner S, Krogan NJ, Oakes SA, Hiniker A. PMID: 35266954; PMCID: PMC8919618.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity. Cell Rep. 2022 03 08; 38(10):110434.
Hage A, Bharaj P, van Tol S, Giraldo MI, Gonzalez-Orozco M, Valerdi KM, Warren AN, Aguilera-Aguirre L, Xie X, Widen SG, Moulton HM, Lee B, Johnson JR, Krogan NJ, García-Sastre A, Shi PY, Freiberg AN, Rajsbaum R. PMID: 35263596; PMCID: PMC8903195.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication. bioRxiv. 2022 Mar 07.
Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JNG, Souza CDS, Zhang S, Azzouz M, Gordon D, Krogan N, Ferraiuolo L, Snyder MP, Shaw PJ, Rehwinkel J, Cooper-Knock J. PMID: 35291294; PMCID: PMC8923113.
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PubMed Mentions:
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Leveraging modeling and simulation to optimize the therapeutic window for epigenetic modifier drugs. Pharmacol Ther. 2022 07; 235:108162.
Walz AC, Van De Vyver AJ, Yu L, Birtwistle MR, Krogan NJ, Bouhaddou M. PMID: 35189161; PMCID: PMC9292061.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Transcription factor protein interactomes reveal genetic determinants in heart disease. Cell. 2022 03 03; 185(5):794-814.e30.
Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D. PMID: 35182466; PMCID: PMC8923057.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Brahma safeguards canalization of cardiac mesoderm differentiation. Nature. 2022 02; 602(7895):129-134.
Hota SK, Rao KS, Blair AP, Khalilimeybodi A, Hu KM, Thomas R, So K, Kameswaran V, Xu J, Polacco BJ, Desai RV, Chatterjee N, Hsu A, Muncie JM, Blotnick AM, Winchester SAB, Weinberger LS, Hüttenhain R, Kathiriya IS, Krogan NJ, Saucerman JJ, Bruneau BG. PMID: 35082446; PMCID: PMC9196993.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission. Cell Host Microbe. 2022 03 09; 30(3):373-387.e7.
Escalera A, Gonzalez-Reiche AS, Aslam S, Mena I, Laporte M, Pearl RL, Fossati A, Rathnasinghe R, Alshammary H, van de Guchte A, Farrugia K, Qin Y, Bouhaddou M, Kehrer T, Zuliani-Alvarez L, Meekins DA, Balaraman V, McDowell C, Richt JA, Bajic G, Sordillo EM, Dejosez M, Zwaka TP, Krogan NJ, Simon V, Albrecht RA, van Bakel H, García-Sastre A, Aydillo T. PMID: 35150638; PMCID: PMC8776496.
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PubMed Mentions:
70 Fields:
Translation:
HumansCells
-
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell. 2022 02 17; 185(4):712-728.e14.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L. PMID: 35063084; PMCID: PMC8857049.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansCells
-
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19. Life Sci Alliance. 2022 04; 5(4).
Varona JF, Landete P, Lopez-Martin JA, Estrada V, Paredes R, Guisado-Vasco P, Fernandez de Orueta L, Torralba M, Fortun J, Vates R, Barberan J, Clotet B, Ancochea J, Carnevali D, Cabello N, Porras L, Gijon P, Monereo A, Abad D, Zuñiga S, Sola I, Rodon J, Vergara-Alert J, Izquierdo-Useros N, Fudio S, Pontes MJ, de Rivas B, Giron de Velasco P, Nieto A, Gomez J, Aviles P, Lubomirov R, Belgrano A, Sopesen B, White KM, Rosales R, Yildiz S, Reuschl AK, Thorne LG, Jolly C, Towers GJ, Zuliani-Alvarez L, Bouhaddou M, Obernier K, McGovern BL, Rodriguez ML, Enjuanes L, Fernandez-Sousa JM, Krogan NJ, Jimeno JM, Garcia-Sastre A. PMID: 35012962; PMCID: PMC8761492.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansCellsCTClinical Trials
-
From systems to structure - using genetic data to model protein structures. Nat Rev Genet. 2022 06; 23(6):342-354.
Braberg H, Echeverria I, Kaake RM, Sali A, Krogan NJ. PMID: 35013567; PMCID: PMC8744059.
View in:
PubMed Mentions:
6 Fields:
-
Comparative Analysis of T-Cell Spatial Proteomics and the Influence of HIV Expression. Mol Cell Proteomics. 2022 03; 21(3):100194.
Oom AL, Stoneham CA, Lewinski MK, Richards A, Wozniak JM, Shams-Ud-Doha K, Gonzalez DJ, Krogan NJ, Guatelli J. PMID: 35017099; PMCID: PMC8956815.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. bioRxiv. 2022 Jan 05.
Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Gross JD, Krogan NJ, Schilling B, Ott M, Verdin E. PMID: 35018374; PMCID: PMC8750649.
View in:
PubMed Mentions:
-
Evolution of enhanced innate immune evasion by SARS-CoV-2. Nature. 2022 02; 602(7897):487-495.
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hiatt J, Rosales R, McGovern BL, Jahun A, Fabius JM, White K, Goodfellow IG, Takeuchi Y, Bonfanti P, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Kellis M, Swaney DL, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. PMID: 34942634; PMCID: PMC8850198.
View in:
PubMed Mentions:
116 Fields:
Translation:
HumansCells
-
Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2. bioRxiv. 2021 Nov 15.
Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Carlson-Stevermer J, Gupta M, Zhang MY, Soveg FW, Hayashi JM, Taha TY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, QCRG Structural Biology Consortium, Krogan N, Galonic Fujimori D, Ott M. PMID: 34816261; PMCID: PMC8609896.
View in:
PubMed Mentions:
2
-
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma. J Clin Invest. 2021 11 15; 131(22).
Jin N, Keam B, Cho J, Lee MJ, Kim HR, Torosyan H, Jura N, Ng PK, Mills GB, Li H, Zeng Y, Barbash Z, Tarcic G, Kang H, Bauman JE, Kim MO, VanLandingham NK, Swaney DL, Krogan NJ, Johnson DE, Grandis JR. PMID: 34779417; PMCID: PMC8592538.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer. JCI Insight. 2021 10 22; 6(20).
Bouhaddou M, Lee RH, Li H, Bhola NE, O'Keefe RA, Naser M, Zhu TR, Nwachuku K, Duvvuri U, Olshen AB, Roy R, Hechmer A, Bolen J, Keysar SB, Jimeno A, Mills GB, Vandenberg S, Swaney DL, Johnson DE, Krogan NJ, Grandis JR. PMID: 34546978; PMCID: PMC8564908.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
-
Systems-level effects of allosteric perturbations to a model molecular switch. Nature. 2021 11; 599(7883):152-157.
Perica T, Mathy CJP, Xu J, Jang G?, Zhang Y, Kaake R, Ollikainen N, Braberg H, Swaney DL, Lambright DG, Kelly MJS, Krogan NJ, Kortemme T. PMID: 34646016; PMCID: PMC8571063.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. Science. 2021 Oct; 374(6563):eabf2911.
Swaney DL, Ramms DJ, Wang Z, Park J, Goto Y, Soucheray M, Bhola N, Kim K, Zheng F, Zeng Y, McGregor M, Herrington KA, O'Keefe R, Jin N, VanLandingham NK, Foussard H, Von Dollen J, Bouhaddou M, Jimenez-Morales D, Obernier K, Kreisberg JF, Kim M, Johnson DE, Jura N, Grandis JR, Gutkind JS, Ideker T, Krogan NJ. PMID: 34591642; PMCID: PMC9005332.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
Interpretation of cancer mutations using a multiscale map of protein systems. Science. 2021 Oct; 374(6563):eabf3067.
Zheng F, Kelly MR, Ramms DJ, Heintschel ML, Tao K, Tutuncuoglu B, Lee JJ, Ono K, Foussard H, Chen M, Herrington KA, Silva E, Liu SN, Chen J, Churas C, Wilson N, Kratz A, Pillich RT, Patel DN, Park J, Kuenzi B, Yu MK, Licon K, Pratt D, Kreisberg JF, Kim M, Swaney DL, Nan X, Fraley SI, Gutkind JS, Krogan NJ, Ideker T. PMID: 34591613; PMCID: PMC9126298.
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PubMed Mentions:
9 Fields:
Translation:
Humans
-
A protein interaction landscape of breast cancer. Science. 2021 Oct; 374(6563):eabf3066.
Kim M, Park J, Bouhaddou M, Kim K, Rojc A, Modak M, Soucheray M, McGregor MJ, O'Leary P, Wolf D, Stevenson E, Foo TK, Mitchell D, Herrington KA, Muñoz DP, Tutuncuoglu B, Chen KH, Zheng F, Kreisberg JF, Diolaiti ME, Gordan JD, Coppé JP, Swaney DL, Xia B, van 't Veer L, Ashworth A, Ideker T, Krogan NJ. PMID: 34591612; PMCID: PMC9040556.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
-
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy. Nat Microbiol. 2021 10; 6(10):1319-1333.
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK. PMID: 34556855; PMCID: PMC9683089.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism. Cell Rep. 2021 09 21; 36(12):109742.
Paulo E, Zhang Y, Masand R, Huynh TL, Seo Y, Swaney DL, Soucheray M, Stevenson E, Jimenez-Morales D, Krogan NJ, Wang B. PMID: 34551310; PMCID: PMC9202523.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches. mSystems. 2021 Oct 26; 6(5):e0038821.
Cakir M, Obernier K, Forget A, Krogan NJ. PMID: 34519533; PMCID: PMC8547474.
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PubMed Mentions:
3 Fields:
-
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia. Curr Biol. 2021 Aug 23; 31(16):3704.
Souilmi Y, Lauterbur ME, Tobler R, Huber CD, Johar AS, Moradi SV, Johnston WA, Krogan NJ, Alexandrov K, Enard D. PMID: 34428405; PMCID: PMC8381604.
View in:
PubMed Mentions:
5 Fields:
-
Characterization of an A3G-VifHIV-1-CRL5-CBFβ Structure Using a Cross-linking Mass Spectrometry Pipeline for Integrative Modeling of Host-Pathogen Complexes. Mol Cell Proteomics. 2021; 20:100132.
Kaake RM, Echeverria I, Kim SJ, Von Dollen J, Chesarino NM, Feng Y, Yu C, Ta H, Chelico L, Huang L, Gross J, Sali A, Krogan NJ. PMID: 34389466; PMCID: PMC8459920.
View in:
PubMed Mentions:
4 Fields:
-
Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection. EMBO J. 2021 09 15; 40(18):e105658.
Batra J, Mori H, Small GI, Anantpadma M, Shtanko O, Mishra N, Zhang M, Liu D, Williams CG, Biedenkopf N, Becker S, Gross ML, Leung DW, Davey RA, Amarasinghe GK, Krogan NJ, Basler CF. PMID: 34260076; PMCID: PMC8441301.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
A ciliopathy complex builds distal appendages to initiate ciliogenesis. J Cell Biol. 2021 09 06; 220(9).
Kumar D, Rains A, Herranz-Pérez V, Lu Q, Shi X, Swaney DL, Stevenson E, Krogan NJ, Huang B, Westlake C, Garcia-Verdugo JM, Yoder BK, Reiter JF. PMID: 34241634; PMCID: PMC8276316.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia. Curr Biol. 2021 08 23; 31(16):3504-3514.e9.
Souilmi Y, Lauterbur ME, Tobler R, Huber CD, Johar AS, Moradi SV, Johnston WA, Krogan NJ, Alexandrov K, Enard D. PMID: 34171302; PMCID: PMC8223470.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCellsPHPublic Health
-
Endosomal cAMP production broadly impacts the cellular phosphoproteome. J Biol Chem. 2021 07; 297(1):100907.
Tsvetanova NG, Trester-Zedlitz M, Newton BW, Peng GE, Johnson JR, Jimenez-Morales D, Kurland AP, Krogan NJ, von Zastrow M. PMID: 34166681; PMCID: PMC8294583.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
-
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science. 2021 07 30; 373(6554):541-547.
Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A, Schadt H, O'Donnell HR, Lyu J, Rosales R, McGovern BL, Rathnasinghe R, Jangra S, Schotsaert M, Galarneau JR, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK. PMID: 34326236; PMCID: PMC8501941.
View in:
PubMed Mentions:
94 Fields:
Translation:
HumansAnimalsCells
-
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant. bioRxiv. 2021 Jun 07.
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Ummadi M, Rojc A, Turner J, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hosmillo M, Hiatt J, Jahun A, Goodfellow IG, Fabius JM, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Swaney DL, Garcia-Sastre A, Jolly C, Towers GJ, Krogan NJ. PMID: 34127972; PMCID: PMC8202424.
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PubMed Mentions:
-
Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization. medRxiv. 2021 May 25.
Varona JF, Landete P, Lopez-Martin JA, Estrada V, Paredes R, Guisado-Vasco P, de Orueta LF, Torralba M, Fortún J, Vates R, Barberán J, Clotet B, Ancochea J, Carnevali D, Cabello N, Porras L, Gijón P, Monereo A, Abad D, Zúñiga S, Sola I, Rodon J, Izquierdo-Useros N, Fudio S, Pontes MJ, de Rivas B, Girón de Velasco P, Sopesén B, Nieto A, Gómez J, Avilés P, Lubomirov R, White KM, Rosales R, Yildiz S, Reuschl AK, Thorne LG, Jolly C, Towers GJ, Zuliani-Alvarez L, Bouhaddou M, Obernier K, Enjuanes L, Fernández-Sousa JM, Plitidepsin – COVID - 19 Study Group, Krogan NJ, Jimeno JM, García-Sastre A. PMID: 34075384; PMCID: PMC8168388.
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PubMed Mentions:
-
Adhesion-mediated mechanosignaling forces mitohormesis. Cell Metab. 2021 07 06; 33(7):1322-1341.e13.
Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM. PMID: 34019840; PMCID: PMC8266765.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
-
Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs. Mol Cell. 2021 05 20; 81(10):2201-2215.e9.
Shiver AL, Osadnik H, Peters JM, Mooney RA, Wu PI, Henry KK, Braberg H, Krogan NJ, Hu JC, Landick R, Huang KC, Gross CA. PMID: 34019789; PMCID: PMC8484514.
View in:
PubMed Mentions:
7 Fields:
Translation:
Cells
-
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19.
Verba K, Gupta M, Azumaya C, Moritz M, Pourmal S, Diallo A, Merz G, Jang G, Bouhaddou M, Fossati A, Brilot A, Diwanji D, Hernandez E, Herrera N, Kratochvil H, Lam V, Li F, Li Y, Nguyen H, Nowotny C, Owens T, Peters J, Rizo A, Schulze-Gahmen U, Smith A, Young I, Yu Z, Asarnow D, Billesbølle C, Campbell M, Chen J, Chen KH, Chio US, Dickinson M, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez K, Mancino A, Iii FM, Paul M, Pawar K, Pelin A, Pospiech T, Puchades C, Remesh S, Safari M, Schaefer K, Sun M, Tabios M, Thwin A, Titus E, Trenker R, Tse E, Tsui TKM, Feng F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, Agard D, Cheng Y, Fraser J, Jura N, Kortemme T, Manglik A, Southworth D, Stroud R, Swaney D, Krogan N, Frost A, Rosenberg O. PMID: 34031651; PMCID: PMC8142659.
View in:
PubMed Mentions:
1
-
Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins. Cell Rep. 2021 05 11; 35(6):109105.
Hiatt J, Cavero DA, McGregor MJ, Zheng W, Budzik JM, Roth TL, Haas KM, Wu D, Rathore U, Meyer-Franke A, Bouzidi MS, Shifrut E, Lee Y, Kumar VE, Dang EV, Gordon DE, Wojcechowskyj JA, Hultquist JF, Fontaine KA, Pillai SK, Cox JS, Ernst JD, Krogan NJ, Marson A. PMID: 33979618; PMCID: PMC8188731.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11.
Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
View in:
PubMed Mentions:
-
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 05 13; 184(10):2696-2714.e25.
Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. PMID: 33891876; PMCID: PMC8152331.
View in:
PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
-
Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PLoS Biol. 2021 04; 19(4):e3001191.
Arveseth CD, Happ JT, Hedeen DS, Zhu JF, Capener JL, Klatt Shaw D, Deshpande I, Liang J, Xu J, Stubben SL, Nelson IB, Walker MF, Kawakami K, Inoue A, Krogan NJ, Grunwald DJ, Hüttenhain R, Manglik A, Myers BR. PMID: 33886552; PMCID: PMC8096101.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
-
The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. Nature. 2021 04; 592(7856):794-798.
Chaikovsky AC, Li C, Jeng EE, Loebell S, Lee MC, Murray CW, Cheng R, Demeter J, Swaney DL, Chen SH, Newton BW, Johnson JR, Drainas AP, Shue YT, Seoane JA, Srinivasan P, He A, Yoshida A, Hipkins SQ, McCrea E, Poltorack CD, Krogan NJ, Diehl JA, Kong C, Jackson PK, Curtis C, Petrov DA, Bassik MC, Winslow MM, Sage J. PMID: 33854239; PMCID: PMC8246597.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
-
Creating collaboration by breaking down scientific barriers. Cell. 2021 04 29; 184(9):2271-2275.
Fabius JM, Krogan NJ. PMID: 33765441; PMCID: PMC8630979.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2. bioRxiv. 2021 Mar 24.
Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, Zhang Z, Alon A, O'Donnell HR, Lyu J, Schadt H, White KM, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK. PMID: 33791693; PMCID: PMC8010720.
View in:
PubMed Mentions:
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Conflicting and ambiguous names of overlapping ORFs in the SARS-CoV-2 genome: A homology-based resolution. Virology. 2021 06; 558:145-151.
Jungreis I, Nelson CW, Ardern Z, Finkel Y, Krogan NJ, Sato K, Ziebuhr J, Stern-Ginossar N, Pavesi A, Firth AE, Gorbalenya AE, Kellis M. PMID: 33774510; PMCID: PMC7967279.
View in:
PubMed Mentions:
25 Fields:
Translation:
Cells
-
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant. bioRxiv. 2021 Feb 04.
Reuschl AK, Thorne LG, Zuliani-Alvarez L, Bouhaddou M, Obernier K, Hiatt J, Soucheray M, Turner J, Fabius JM, Nguyen GT, Swaney DL, Rosales R, White KM, Avilés P, Kirby IT, Melnyk JE, Shi Y, Zhang Z, Shokat KM, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. PMID: 33501437; PMCID: PMC7836107.
View in:
PubMed Mentions:
3
-
Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo. J Virol. 2021 03 25; 95(8).
Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. PMID: 33536176; PMCID: PMC8103695.
View in:
PubMed Mentions:
9 Fields:
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SUMO is a pervasive regulator of meiosis. Elife. 2021 01 27; 10.
Bhagwat NR, Owens SN, Ito M, Boinapalli JV, Poa P, Ditzel A, Kopparapu S, Mahalawat M, Davies OR, Collins SR, Johnson JR, Krogan NJ, Hunter N. PMID: 33502312; PMCID: PMC7924959.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. Science. 2021 02 26; 371(6532):926-931.
White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guillén MJ, Losada A, Avilés P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, García-Sastre A. PMID: 33495306; PMCID: PMC7963220.
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PubMed Mentions:
137 Fields:
Translation:
HumansAnimalsCells
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Proteomic Approaches to Study SARS-CoV-2 Biology and COVID-19 Pathology. J Proteome Res. 2021 02 05; 20(2):1133-1152.
Haas P, Muralidharan M, Krogan NJ, Kaake RM, Hüttenhain R. PMID: 33464917; PMCID: PMC7839417.
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PubMed Mentions:
12 Fields:
Translation:
HumansCellsPHPublic Health
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Mass spectrometry-based protein-protein interaction networks for the study of human diseases. Mol Syst Biol. 2021 01; 17(1):e8792.
Richards AL, Eckhardt M, Krogan NJ. PMID: 33434350; PMCID: PMC7803364.
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PubMed Mentions:
41 Fields:
Translation:
Humans
-
Genetic interaction mapping informs integrative structure determination of protein complexes. Science. 2020 12 11; 370(6522).
Braberg H, Echeverria I, Bohn S, Cimermancic P, Shiver A, Alexander R, Xu J, Shales M, Dronamraju R, Jiang S, Dwivedi G, Bogdanoff D, Chaung KK, Hüttenhain R, Wang S, Mavor D, Pellarin R, Schneidman D, Bader JS, Fraser JS, Morris J, Haber JE, Strahl BD, Gross CA, Dai J, Boeke JD, Sali A, Krogan NJ. PMID: 33303586; PMCID: PMC7946025.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses. Cell. 2021 01 07; 184(1):106-119.e14.
Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS. PMID: 33333024; PMCID: PMC7723770.
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PubMed Mentions:
175 Fields:
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HumansAnimalsCells
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An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 12 18; 370(6523):1473-1479.
Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 33154106; PMCID: PMC7857409.
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PubMed Mentions:
198 Fields:
Translation:
HumansAnimalsCells
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SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28344-28354.
Miorin L, Kehrer T, Sanchez-Aparicio MT, Zhang K, Cohen P, Patel RS, Cupic A, Makio T, Mei M, Moreno E, Danziger O, White KM, Rathnasinghe R, Uccellini M, Gao S, Aydillo T, Mena I, Yin X, Martin-Sancho L, Krogan NJ, Chanda SK, Schotsaert M, Wozniak RW, Ren Y, Rosenberg BR, Fontoura BMA, García-Sastre A. PMID: 33097660; PMCID: PMC7668094.
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PubMed Mentions:
244 Fields:
Translation:
HumansAnimalsCells
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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521).
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, et al. PMID: 33060197; PMCID: PMC7808408.
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PubMed Mentions:
309 Fields:
Translation:
HumansCells
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Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses. bioRxiv. 2020 Sep 24.
Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi JM, Carlson-Stevermer J, Oki J, Holden K, Krogan NJ, Ott M, Puschnik AS. PMID: 32995787; PMCID: PMC7523113.
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PubMed Mentions:
1
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The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription. Cells. 2020 09 01; 9(9).
Langer S, Yin X, Diaz A, Portillo AJ, Gordon DE, Rogers UH, Marlett JM, Krogan NJ, Young JAT, Pache L, Chanda SK. PMID: 32882949; PMCID: PMC7564853.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 10; 38(10):1174-1183.
Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32855547; PMCID: PMC7740072.
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PubMed Mentions:
149 Fields:
Translation:
HumansCellsPHPublic Health
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SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells. bioRxiv. 2020 Aug 19.
Dominguez Andres A, Feng Y, Campos AR, Yin J, Yang CC, James B, Murad R, Kim H, Deshpande AJ, Gordon DE, Krogan N, Pippa R, Ronai ZA. PMID: 32839770; PMCID: PMC7444281.
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PubMed Mentions:
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An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation. bioRxiv. 2020 Aug 17.
Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 32817938; PMCID: PMC7430568.
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PubMed Mentions:
1
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Structural basis of CD4 downregulation by HIV-1 Nef. Nat Struct Mol Biol. 2020 09; 27(9):822-828.
Kwon Y, Kaake RM, Echeverria I, Suarez M, Karimian Shamsabadi M, Stoneham C, Ramirez PW, Kress J, Singh R, Sali A, Krogan N, Guatelli J, Jia X. PMID: 32719457; PMCID: PMC7483821.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Envelope protein ubiquitination drives entry and pathogenesis of Zika virus. Nature. 2020 09; 585(7825):414-419.
Giraldo MI, Xia H, Aguilera-Aguirre L, Hage A, van Tol S, Shan C, Xie X, Sturdevant GL, Robertson SJ, McNally KL, Meade-White K, Azar SR, Rossi SL, Maury W, Woodson M, Ramage H, Johnson JR, Krogan NJ, Morais MC, Best SM, Shi PY, Rajsbaum R. PMID: 32641828; PMCID: PMC7501154.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Correction: Thioredoxin-related protein 32 is an arsenite-regulated thiol reductase of the proteasome 19 S particle. J Biol Chem. 2020 Jul 03; 295(27):9267.
Wiseman RL, Chin KT, Haynes CM, Stanhill A, Xu CF, Roguev A, Krogan NJ, Neubert TA, Ron D. PMID: 32620695; PMCID: PMC7335781.
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PubMed Mentions: Fields:
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 08 06; 182(3):685-712.e19.
Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero D, Zhou Y, Dugourd A, Valdeolivas A, Patil T, Li Q, Hüttenhain R, Cakir M, Muralidharan M, Kim M, Jang G, Tutuncuoglu B, Hiatt J, Guo JZ, Xu J, Bouhaddou S, Mathy CJP, Gaulton A, Manners EJ, Félix E, Shi Y, Goff M, Lim JK, McBride T, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, De Wit E, Leach AR, Kortemme T, Shoichet B, Ott M, Saez-Rodriguez J, tenOever BR, Mullins RD, Fischer ER, Kochs G, Grosse R, García-Sastre A, Vignuzzi M, Johnson JR, Shokat KM, Swaney DL, Beltrao P, Krogan NJ. PMID: 32645325; PMCID: PMC7321036.
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The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae. PLoS Genet. 2020 06; 16(6):e1008840.
Alme EB, Stevenson E, Krogan NJ, Swaney DL, Toczyski DP. PMID: 32579556; PMCID: PMC7340321.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection. Cell. 2020 06 25; 181(7):1502-1517.e23.
Ho JSY, Angel M, Ma Y, Sloan E, Wang G, Martinez-Romero C, Alenquer M, Roudko V, Chung L, Zheng S, Chang M, Fstkchyan Y, Clohisey S, Dinan AM, Gibbs J, Gifford R, Shen R, Gu Q, Irigoyen N, Campisi L, Huang C, Zhao N, Jones JD, van Knippenberg I, Zhu Z, Moshkina N, Meyer L, Noel J, Peralta Z, Rezelj V, Kaake R, Rosenberg B, Wang B, Wei J, Paessler S, Wise HM, Johnson J, Vannini A, Amorim MJ, Baillie JK, Miraldi ER, Benner C, Brierley I, Digard P, Luksza M, Firth AE, Krogan N, Greenbaum BD, MacLeod MK, van Bakel H, Garcìa-Sastre A, Yewdell JW, Hutchinson E, Marazzi I. PMID: 32559462; PMCID: PMC7323901.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells. Cancer Cell. 2020 07 13; 38(1):129-143.e7.
Coles GL, Cristea S, Webber JT, Levin RS, Moss SM, He A, Sangodkar J, Hwang YC, Arand J, Drainas AP, Mooney NA, Demeter J, Spradlin JN, Mauch B, Le V, Shue YT, Ko JH, Lee MC, Kong C, Nomura DK, Ohlmeyer M, Swaney DL, Krogan NJ, Jackson PK, Narla G, Gordan JD, Shokat KM, Sage J. PMID: 32531271; PMCID: PMC7363571.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2. Cancer Discov. 2020 07; 10(7):916-921.
Tutuncuoglu B, Cakir M, Batra J, Bouhaddou M, Eckhardt M, Gordon DE, Krogan NJ. PMID: 32444466; PMCID: PMC7357668.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCellsPHPublic Health
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Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020 May 17.
Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32511497; PMCID: PMC7273265.
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PubMed Mentions:
16
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mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1. Nat Commun. 2020 05 15; 11(1):2449.
Du Y, Hultquist JF, Zhou Q, Olson A, Tseng Y, Zhang TH, Hong M, Tang K, Chen L, Meng X, McGregor MJ, Dai L, Gong D, Martin-Sancho L, Chanda S, Li X, Bensenger S, Krogan NJ, Sun R. PMID: 32415096; PMCID: PMC7229031.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
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A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. PMID: 32511329; PMCID: PMC7239059.
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28
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Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core. Cell Rep. 2020 03 17; 30(11):3766-3777.e6.
Selyutina A, Persaud M, Simons LM, Bulnes-Ramos A, Buffone C, Martinez-Lopez A, Scoca V, Di Nunzio F, Hiatt J, Marson A, Krogan NJ, Hultquist JF, Diaz-Griffero F. PMID: 32187548; PMCID: PMC7363000.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansCells
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A Quantitative Genetic Interaction Map of HIV Infection. Mol Cell. 2020 04 16; 78(2):197-209.e7.
Gordon DE, Watson A, Roguev A, Zheng S, Jang GM, Kane J, Xu J, Guo JZ, Stevenson E, Swaney DL, Franks-Skiba K, Verschueren E, Shales M, Crosby DC, Frankel AD, Marson A, Marazzi I, Cagney G, Krogan NJ. PMID: 32084337; PMCID: PMC7462049.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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A systems approach to infectious disease. Nat Rev Genet. 2020 06; 21(6):339-354.
Eckhardt M, Hultquist JF, Kaake RM, Hüttenhain R, Krogan NJ. PMID: 32060427; PMCID: PMC7839161.
View in:
PubMed Mentions:
47 Fields:
Translation:
Humans
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Dynamic post-translational modification profiling of Mycobacterium tuberculosis-infected primary macrophages. Elife. 2020 01 17; 9.
Budzik JM, Swaney DL, Jimenez-Morales D, Johnson JR, Garelis NE, Repasy T, Roberts AW, Popov LM, Parry TJ, Pratt D, Ideker T, Krogan NJ, Cox JS. PMID: 31951200; PMCID: PMC7030789.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant. iScience. 2020 Jan 24; 23(1):100809.
Antoine M, Patrick KL, Soret J, Duc P, Rage F, Cacciottolo R, Nissen KE, Cauchi RJ, Krogan NJ, Guthrie C, Gachet Y, Bordonné R. PMID: 31927482; PMCID: PMC6957872.
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PubMed Mentions:
3
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The functional landscape of the human phosphoproteome. Nat Biotechnol. 2020 03; 38(3):365-373.
Ochoa D, Jarnuczak AF, Viéitez C, Gehre M, Soucheray M, Mateus A, Kleefeldt AA, Hill A, Garcia-Alonso L, Stein F, Krogan NJ, Savitski MM, Swaney DL, Vizcaíno JA, Noh KM, Beltrao P. PMID: 31819260; PMCID: PMC7100915.
View in:
PubMed Mentions:
110 Fields:
Translation:
HumansCells
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Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly. Dev Cell. 2019 12 16; 51(6):713-729.e6.
Link N, Chung H, Jolly A, Withers M, Tepe B, Arenkiel BR, Shah PS, Krogan NJ, Aydin H, Geckinli BB, Tos T, Isikay S, Tuysuz B, Mochida GH, Thomas AX, Clark RD, Mirzaa GM, Lupski JR, Bellen HJ. PMID: 31735666; PMCID: PMC6917859.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Mapping genetic interactions in cancer: a road to rational combination therapies. Genome Med. 2019 10 22; 11(1):62.
Tutuncuoglu B, Krogan NJ. PMID: 31640753; PMCID: PMC6805649.
View in:
PubMed Mentions:
10 Fields:
Translation:
Humans
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UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. Nature. 2019 11; 575(7782):366-370.
Majer O, Liu B, Kreuk LSM, Krogan N, Barton GM. PMID: 31546246; PMCID: PMC6856441.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen. Cell Host Microbe. 2019 10 09; 26(4):551-563.e6.
Jeng EE, Bhadkamkar V, Ibe NU, Gause H, Jiang L, Chan J, Jian R, Jimenez-Morales D, Stevenson E, Krogan NJ, Swaney DL, Snyder MP, Mukherjee S, Bassik MC. PMID: 31540829; PMCID: PMC6800164.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Enterovirus pathogenesis requires the host methyltransferase SETD3. Nat Microbiol. 2019 12; 4(12):2523-2537.
Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE. PMID: 31527793; PMCID: PMC6879830.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast. J Biol Chem. 2019 11 01; 294(44):16080-16094.
Aristizabal MJ, Dever K, Negri GL, Shen M, Hawe N, Benschop JJ, Holstege FCP, Krogan NJ, Sadowski I, Kobor MS. PMID: 31506296; PMCID: PMC6827322.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Anti-CRISPR-Associated Proteins Are Crucial Repressors of Anti-CRISPR Transcription. Cell. 2019 09 05; 178(6):1452-1464.e13.
Stanley SY, Borges AL, Chen KH, Swaney DL, Krogan NJ, Bondy-Denomy J, Davidson AR. PMID: 31474367; PMCID: PMC6754177.
View in:
PubMed Mentions:
45 Fields:
Translation:
Cells
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Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers. Cell Rep. 2019 08 27; 28(9):2317-2330.e8.
Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, Asthana S, Ideker T, Wu W, Suzuki J, Barad BA, Kirichok Y, Fraser JS, Weiss WA, Krogan NJ, Tulpule A, Sabnis AJ, Bivona TG. PMID: 31461649; PMCID: PMC6728083.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells. Nat Biotechnol. 2019 09; 37(9):1034-1037.
Leenay RT, Aghazadeh A, Hiatt J, Tse D, Roth TL, Apathy R, Shifrut E, Hultquist JF, Krogan N, Wu Z, Cirolia G, Canaj H, Leonetti MD, Marson A, May AP, Zou J. PMID: 31359007; PMCID: PMC7388783.
View in:
PubMed Mentions:
46 Fields:
Translation:
HumansCells
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PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization. Proc Natl Acad Sci U S A. 2019 07 30; 116(31):15495-15504.
Lopez ML, Lo M, Kung JE, Dudkiewicz M, Jang GM, Von Dollen J, Johnson JR, Krogan NJ, Pawlowski K, Jura N. PMID: 31311869; PMCID: PMC6681764.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Mapping the protein-protein and genetic interactions of cancer to guide precision medicine. Curr Opin Genet Dev. 2019 02; 54:110-117.
Bouhaddou M, Eckhardt M, Chi Naing ZZ, Kim M, Ideker T, Krogan NJ. PMID: 31288129; PMCID: PMC6746583.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis. Development. 2019 07 05; 146(19).
Hota SK, Johnson JR, Verschueren E, Thomas R, Blotnick AM, Zhu Y, Sun X, Pennacchio LA, Krogan NJ, Bruneau BG. PMID: 30814119; PMCID: PMC6803373.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria. mBio. 2019 06 25; 10(3).
Fay A, Czudnochowski N, Rock JM, Johnson JR, Krogan NJ, Rosenberg O, Glickman MS. PMID: 31239378; PMCID: PMC6593404.
View in:
PubMed Mentions:
18 Fields:
Translation:
Cells
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ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host Microbe. 2019 07 10; 26(1):86-99.e7.
Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ. PMID: 31253590; PMCID: PMC7153695.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation. J Exp Clin Cancer Res. 2019 Jun 13; 38(1):251.
Da Costa EM, Armaos G, McInnes G, Beaudry A, Moquin-Beaudry G, Bertrand-Lehouillier V, Caron M, Richer C, St-Onge P, Johnson JR, Krogan N, Sai Y, Downey M, Rafei M, Boileau M, Eppert K, Flores-Díaz E, Haman A, Hoang T, Sinnett D, Beauséjour C, McGraw S, Raynal NJ. PMID: 31196146; PMCID: PMC6563382.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11291-11298.
Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR. PMID: 31101715; PMCID: PMC6561268.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins. Mol Cell. 2019 06 20; 74(6):1164-1174.e4.
Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M. PMID: 31054975; PMCID: PMC6588463.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1. Mol Metab. 2019 07; 25:35-49.
Sebaa R, Johnson J, Pileggi C, Norgren M, Xuan J, Sai Y, Tong Q, Krystkowiak I, Bondy-Chorney E, Davey NE, Krogan N, Downey M, Harper ME. PMID: 31060926; PMCID: PMC6601363.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Identification of antiviral roles for the exon-junction complex and nonsense-mediated decay in flaviviral infection. Nat Microbiol. 2019 06; 4(6):985-995.
Li M, Johnson JR, Truong B, Kim G, Weinbren N, Dittmar M, Shah PS, Von Dollen J, Newton BW, Jang GM, Krogan NJ, Cherry S, Ramage H. PMID: 30833725; PMCID: PMC6533143.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function. J Alzheimers Dis. 2019; 68(3):991-1011.
Orr AL, Kim C, Jimenez-Morales D, Newton BW, Johnson JR, Krogan NJ, Swaney DL, Mahley RW. PMID: 30883359; PMCID: PMC6481541.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions. Nat Protoc. 2019 01; 14(1):1-27.
Hultquist JF, Hiatt J, Schumann K, McGregor MJ, Roth TL, Haas P, Doudna JA, Marson A, Krogan NJ. PMID: 30559373; PMCID: PMC6637941.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansCells
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TCO, a Putative Transcriptional Regulator in Arabidopsis, Is a Target of the Protein Kinase CK2. Int J Mol Sci. 2018 Dec 28; 20(1).
Weinman LM, Running KLD, Carey NS, Stevenson EJ, Swaney DL, Chow BY, Krogan NJ, Krogan NT. PMID: 30597831; PMCID: PMC6337506.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Genetic analysis reveals functions of atypical polyubiquitin chains. Elife. 2018 12 14; 7.
Meza Gutierrez F, Simsek D, Mizrak A, Deutschbauer A, Braberg H, Johnson J, Xu J, Shales M, Nguyen M, Tamse-Kuehn R, Palm C, Steinmetz LM, Krogan NJ, Toczyski DP. PMID: 30547882; PMCID: PMC6305200.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Cell. 2018 12 13; 175(7):1931-1945.e18.
Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ. PMID: 30550790; PMCID: PMC6474419.
View in:
PubMed Mentions:
147 Fields:
Translation:
HumansAnimalsCells
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Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication. Cell. 2018 12 13; 175(7):1917-1930.e13.
Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, Haas P, Schmidt CB, Schlesinger LS, LaCount DJ, Davey RA, Amarasinghe GK, Basler CF, Krogan NJ. PMID: 30550789; PMCID: PMC6366944.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansCells
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Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets. Antiviral Res. 2019 02; 162:90-100.
Basler CF, Krogan NJ, Leung DW, Amarasinghe GK. PMID: 30550800; PMCID: PMC6457457.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1. G3 (Bethesda). 2018 12 10; 8(12):3931-3944.
Lao JP, Ulrich KM, Johnson JR, Newton BW, Vashisht AA, Wohlschlegel JA, Krogan NJ, Toczyski DP. PMID: 30377154; PMCID: PMC6288840.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status. Redox Biol. 2019 01; 20:533-543.
Bramasole L, Sinha A, Gurevich S, Radzinski M, Klein Y, Panat N, Gefen E, Rinaldi T, Jimenez-Morales D, Johnson J, Krogan NJ, Reis N, Reichmann D, Glickman MH, Pick E. PMID: 30508698; PMCID: PMC6279957.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
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The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein. mBio. 2018 11 06; 9(6).
Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M. PMID: 30401782; PMCID: PMC6222128.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network. Cancer Discov. 2018 11; 8(11):1474-1489.
Eckhardt M, Zhang W, Gross AM, Von Dollen J, Johnson JR, Franks-Skiba KE, Swaney DL, Johnson TL, Jang GM, Shah PS, Brand TM, Archambault J, Kreisberg JF, Grandis JR, Ideker T, Krogan NJ. PMID: 30209081; PMCID: PMC6375299.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansCells
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EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion. Sci Rep. 2018 09 05; 8(1):13269.
Gaber A, Kim SJ, Kaake RM, Bencina M, Krogan N, Šali A, Pavšic M, Lenarcic B. PMID: 30185875; PMCID: PMC6125409.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Influenza virus infection causes global RNAPII termination defects. Nat Struct Mol Biol. 2018 09; 25(9):885-893.
Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, Ma Y, Rialdi A, Albrecht R, Fenouil R, Sánchez-Aparicio MT, Ayllon J, Ravisankar S, Haddad B, Ho JSY, Low D, Jin J, Yurchenko V, Prinjha RK, Tarakhovsky A, Squatrito M, Pinto D, Allette K, Byun M, Smith ML, Sebra R, Guccione E, Tumpey T, Krogan N, Greenbaum B, van Bakel H, García-Sastre A, Marazzi I. PMID: 30177761.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18).
Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. PMID: 30166453; PMCID: PMC6138441.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease. Mol Cell. 2018 10 04; 72(1):152-161.e7.
Wipperman MF, Heaton BE, Nautiyal A, Adefisayo O, Evans H, Gupta R, van Ditmarsch D, Soni R, Hendrickson R, Johnson J, Krogan N, Glickman MS. PMID: 30174294; PMCID: PMC6389330.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses. Mol Cell. 2018 08 16; 71(4):637-648.e5.
Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Ohol YM, Maher C, Bell SL, Geiger K, Golovkine G, Du X, Choi A, Parry T, Mohapatra BC, Storck MD, Band H, Chen C, Jäger S, Shales M, Portnoy DA, Hernandez R, Coscoy L, Cox JS, Krogan NJ. PMID: 30118682; PMCID: PMC6329589.
View in:
PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection. Cell Syst. 2018 09 26; 7(3):323-338.e6.
Patrick KL, Wojcechowskyj JA, Bell SL, Riba MN, Jing T, Talmage S, Xu P, Cabello AL, Xu J, Shales M, Jimenez-Morales D, Ficht TA, de Figueiredo P, Samuel JE, Li P, Krogan NJ, Watson RO. PMID: 30077634; PMCID: PMC6160342.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520.
Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424; PMCID: PMC6247911.
View in:
PubMed Mentions:
57 Fields:
Translation:
Humans
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Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis. Sci Rep. 2018 Jul 20; 8(1):11001.
Paulo E, Wu D, Wang Y, Zhang Y, Wu Y, Swaney DL, Soucheray M, Jimenez-Morales D, Chawla A, Krogan NJ, Wang B. PMID: 30030465; PMCID: PMC6054673.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife. 2018 05 30; 7.
Faust TB, Li Y, Bacon CW, Jang GM, Weiss A, Jayaraman B, Newton BW, Krogan NJ, D'Orso I, Frankel AD. PMID: 29845934; PMCID: PMC5999396.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Author Correction: SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep. 2018 May 14; 8(1):7782.
Dornfeld D, Dudek AH, Vausselin T, Günther SC, Hultquist JF, Giese S, Khokhlova-Cubberley D, Chew YC, Pache L, Krogan NJ, Garcia-Sastre A, Schwemmle M, Shaw ML. PMID: 29760472; PMCID: PMC5951913.
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PubMed Mentions: Fields:
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The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells. Mol Cell. 2018 04 19; 70(2):371-379.e5.
Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP, Cagney G. PMID: 29606589.
View in:
PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy. J Neurosci. 2018 04 11; 38(15):3680-3688.
Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok SA, Gestwicki JE, Gan L. PMID: 29540553; PMCID: PMC5895994.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab. 2018 03 06; 27(3):616-629.e4.
Masand R, Paulo E, Wu D, Wang Y, Swaney DL, Jimenez-Morales D, Krogan NJ, Wang B. PMID: 29514069; PMCID: PMC6020063.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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How many human proteoforms are there? Nat Chem Biol. 2018 02 14; 14(3):206-214.
Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. PMID: 29443976; PMCID: PMC5837046.
View in:
PubMed Mentions:
255 Fields:
Translation:
HumansCells
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Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Cancer Res. 2018 05 01; 78(9):2383-2395.
Brand TM, Hartmann S, Bhola NE, Li H, Zeng Y, O'Keefe RA, Ranall MV, Bandyopadhyay S, Soucheray M, Krogan NJ, Kemp C, Duvvuri U, LaVallee T, Johnson DE, Ozbun MA, Bauman JE, Grandis JR. PMID: 29440171; PMCID: PMC6537867.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep. 2018 02 01; 8(1):2092.
Dornfeld D, Dudek AH, Vausselin T, Günther SC, Hultquist JF, Giese S, Khokhlova-Cubberley D, Chew YC, Pache L, Krogan NJ, Garcia-Sastre A, Schwemmle M, Shaw ML. PMID: 29391557; PMCID: PMC5794779.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
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High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe. Cold Spring Harb Protoc. 2018 02 01; 2018(2).
Roguev A, Ryan CJ, Hartsuiker E, Krogan NJ. PMID: 28733404; PMCID: PMC6764749.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Genetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast. Cold Spring Harb Protoc. 2018 02 01; 2018(2).
Roguev A, Ryan CJ, Xu J, Colson I, Hartsuiker E, Krogan N. PMID: 28733406.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Genetic Interaction Mapping in Schizosaccharomyces pombe Using the Pombe Epistasis Mapper (PEM) System and a ROTOR HDA Colony Replicating Robot in a 1536 Array Format. Cold Spring Harb Protoc. 2018 02 01; 2018(2).
Roguev A, Xu J, Krogan N. PMID: 28733394.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
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Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. PLoS Pathog. 2018 01; 14(1):e1006830.
Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD. PMID: 29304101; PMCID: PMC5773222.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Transformation of Schizosaccharomyces pombe in a 96-Well Format. Cold Spring Harb Protoc. 2018 01 02; 2018(1).
Roguev A, Xu J, Krogan NJ. PMID: 28733397.
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PubMed Mentions: Fields:
Translation:
Animals
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DNA Preparation from Schizosaccharomyces pombe. Cold Spring Harb Protoc. 2018 01 02; 2018(1).
Roguev A, Xu J, Krogan NJ. PMID: 28733411.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017 12 18; 43(6):744-762.e11.
Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF. PMID: 29257953; PMCID: PMC5752135.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. J Exp Med. 2018 01 02; 215(1):51-62.
Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M. PMID: 29191913; PMCID: PMC5748845.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansCells
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Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects. J Exp Med. 2017 Dec 04; 214(12):3707-3729.
Rujano MA, Cannata Serio M, Panasyuk G, Péanne R, Reunert J, Rymen D, Hauser V, Park JH, Freisinger P, Souche E, Guida MC, Maier EM, Wada Y, Jäger S, Krogan NJ, Kretz O, Nobre S, Garcia P, Quelhas D, Bird TD, Raskind WH, Schwake M, Duvet S, Foulquier F, Matthijs G, Marquardt T, Simons M. PMID: 29127204; PMCID: PMC5716037.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes. Genetics. 2018 01; 208(1):419-431.
Espinosa-Cantú A, Ascencio D, Herrera-Basurto S, Xu J, Roguev A, Krogan NJ, DeLuna A. PMID: 29127264; PMCID: PMC5753873.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication. J Virol. 2017 09 15; 91(18).
Bharaj P, Atkins C, Luthra P, Giraldo MI, Dawes BE, Miorin L, Johnson JR, Krogan NJ, Basler CF, Freiberg AN, Rajsbaum R. PMID: 28679761; PMCID: PMC5571272.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress. JCI Insight. 2017 Jul 20; 2(14).
Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR. PMID: 28724793; PMCID: PMC5518554.
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PubMed Mentions:
45 Fields:
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Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling. J Virol. 2017 08 01; 91(15).
Gong D, Dai X, Xiao Y, Du Y, Chapa TJ, Johnson JR, Li X, Krogan NJ, Deng H, Wu TT, Sun R. PMID: 28515293; PMCID: PMC5651724.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
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The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling. ACS Infect Dis. 2017 08 11; 3(8):564-574.
Sogi KM, Lien KA, Johnson JR, Krogan NJ, Stanley SA. PMID: 28537707; PMCID: PMC5728371.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency. Cell Host Microbe. 2017 May 10; 21(5):569-579.e6.
Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M. PMID: 28494238; PMCID: PMC5490666.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Genetic interaction mapping in mammalian cells using CRISPR interference. Nat Methods. 2017 Jun; 14(6):577-580.
Du D, Roguev A, Gordon DE, Chen M, Chen SH, Shales M, Shen JP, Ideker T, Mali P, Qi LS, Krogan NJ. PMID: 28481362; PMCID: PMC5584685.
View in:
PubMed Mentions:
67 Fields:
Translation:
AnimalsCells
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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity. Cell. 2017 05 04; 169(4):679-692.e14.
Rialdi A, Hultquist J, Jimenez-Morales D, Peralta Z, Campisi L, Fenouil R, Moshkina N, Wang ZZ, Laffleur B, Kaake RM, McGregor MJ, Haas K, Pefanis E, Albrecht RA, Pache L, Chanda S, Jen J, Ochando J, Byun M, Basu U, García-Sastre A, Krogan N, van Bakel H, Marazzi I. PMID: 28475896; PMCID: PMC6217988.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell. 2017 04 06; 169(2):350-360.e12.
Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ. PMID: 28388416; PMCID: PMC5616215.
View in:
PubMed Mentions:
155 Fields:
Translation:
HumansAnimalsCells
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The histone variant H2A.Z promotes splicing of weak introns. Genes Dev. 2017 04 01; 31(7):688-701.
Nissen KE, Homer CM, Ryan CJ, Shales M, Krogan NJ, Patrick KL, Guthrie C. PMID: 28446597; PMCID: PMC5411709.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription. Sci Rep. 2017 03 27; 7:45394.
Faust TB, Li Y, Jang GM, Johnson JR, Yang S, Weiss A, Krogan NJ, Frankel AD. PMID: 28345603; PMCID: PMC5366948.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. Nat Methods. 2017 Jun; 14(6):573-576.
Shen JP, Zhao D, Sasik R, Luebeck J, Birmingham A, Bojorquez-Gomez A, Licon K, Klepper K, Pekin D, Beckett AN, Sanchez KS, Thomas A, Kuo CC, Du D, Roguev A, Lewis NE, Chang AN, Kreisberg JF, Krogan N, Qi L, Ideker T, Mali P. PMID: 28319113; PMCID: PMC5449203.
View in:
PubMed Mentions:
160 Fields:
Translation:
HumansCells
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Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction. Elife. 2017 03 02; 6.
Elwell CA, Czudnochowski N, von Dollen J, Johnson JR, Nakagawa R, Mirrashidi K, Krogan NJ, Engel JN, Rosenberg OS. PMID: 28252385; PMCID: PMC5364026.
View in:
PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. Nat Microbiol. 2017 Mar 01; 2:17022.
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VR, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK. PMID: 28248290; PMCID: PMC5338947.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Elife. 2017 01 10; 6.
Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL. PMID: 28072389; PMCID: PMC5283830.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Inhibition of CRISPR-Cas9 with Bacteriophage Proteins. Cell. 2017 Jan 12; 168(1-2):150-158.e10.
Rauch BJ, Silvis MR, Hultquist JF, Waters CS, McGregor MJ, Krogan NJ, Bondy-Denomy J. PMID: 28041849; PMCID: PMC5235966.
View in:
PubMed Mentions:
192 Fields:
Translation:
HumansCells
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A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat Genet. 2017 Feb; 49(2):193-203.
Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD. PMID: 27992415; PMCID: PMC5511375.
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PubMed Mentions:
154 Fields:
Translation:
HumansCells
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The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797.
Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. PMID: 27978436; PMCID: PMC5354304.
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PubMed Mentions:
114 Fields:
Translation:
HumansCells
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G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. Mol Pharmacol. 2017 Feb; 91(2):145-156.
Tsvetanova NG, Trester-Zedlitz M, Newton BW, Riordan DP, Sundaram AB, Johnson JR, Krogan NJ, von Zastrow M. PMID: 27879340; PMCID: PMC5267521.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
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A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export. Cell Host Microbe. 2016 Nov 09; 20(5):642-653.
Gong D, Kim YH, Xiao Y, Du Y, Xie Y, Lee KK, Feng J, Farhat N, Zhao D, Shu S, Dai X, Chanda SK, Rana TM, Krogan NJ, Sun R, Wu TT. PMID: 27832591; PMCID: PMC5130111.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome. Mol Cell Biol. 2016 11 15; 36(22):2768-2781.
Steunou AL, Cramet M, Rossetto D, Aristizabal MJ, Lacoste N, Drouin S, Côté V, Paquet E, Utley RT, Krogan N, Robert F, Kobor MS, Côté J. PMID: 27550811; PMCID: PMC5086519.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate. Neuron. 2016 Nov 23; 92(4):813-828.
Jayaraman D, Kodani A, Gonzalez DM, Mancias JD, Mochida GH, Vagnoni C, Johnson J, Krogan N, Harper JW, Reiter JF, Yu TW, Bae BI, Walsh CA. PMID: 27974163; PMCID: PMC5199216.
View in:
PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. 2016 10 25; 17(5):1438-1452.
Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ, Marson A. PMID: 27783955; PMCID: PMC5123761.
View in:
PubMed Mentions:
94 Fields:
Translation:
HumansCells
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The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing. PLoS Pathog. 2016 08; 12(8):e1005841.
De Maio FA, Risso G, Iglesias NG, Shah P, Pozzi B, Gebhard LG, Mammi P, Mancini E, Yanovsky MJ, Andino R, Krogan N, Srebrow A, Gamarnik AV. PMID: 27575636; PMCID: PMC5004807.
View in:
PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
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A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S. PLoS Genet. 2016 06; 12(6):e1006124.
Shiver AL, Osadnik H, Kritikos G, Li B, Krogan N, Typas A, Gross CA. PMID: 27355376; PMCID: PMC4927156.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Non-degradative Ubiquitination of Protein Kinases. PLoS Comput Biol. 2016 06; 12(6):e1004898.
Ball KA, Johnson JR, Lewinski MK, Guatelli J, Verschueren E, Krogan NJ, Jacobson MP. PMID: 27253329; PMCID: PMC4890936.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
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A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa. Mol Microbiol. 2016 08; 101(4):590-605.
Inclan YF, Persat A, Greninger A, Von Dollen J, Johnson J, Krogan N, Gitai Z, Engel JN. PMID: 27145134; PMCID: PMC4980298.
View in:
PubMed Mentions:
38 Fields:
Translation:
Cells
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Nonsense-mediated decay regulates key components of homologous recombination. Nucleic Acids Res. 2016 06 20; 44(11):5218-30.
Janke R, Kong J, Braberg H, Cantin G, Yates JR, Krogan NJ, Heyer WD. PMID: 27001511; PMCID: PMC4914092.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. 2016 Apr 07; 18(4):541-53.
Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR. PMID: 26971820; PMCID: PMC4830697.
View in:
PubMed Mentions:
208 Fields:
Translation:
HumansCells
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Translation of Genotype to Phenotype by a Hierarchy of Cell Subsystems. Cell Syst. 2016 Feb 24; 2(2):77-88.
Yu MK, Kramer M, Dutkowski J, Srivas R, Licon K, Kreisberg J, Ng CT, Krogan N, Sharan R, Ideker T. PMID: 26949740; PMCID: PMC4772745.
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PubMed Mentions:
40 Fields:
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Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity. 2016 Jan 19; 44(1):46-58.
Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. PMID: 26789921; PMCID: PMC4878455.
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PubMed Mentions:
75 Fields:
Translation:
HumansCells
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Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. Cell Host Microbe. 2015 Dec 09; 18(6):723-35.
Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LC, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, Gonzalez MG, Nguyen Q, Brass A, Elledge S, White M, Shapira S, Hacohen N, Karlas A, Meyer TF, Shales M, Gatorano A, Johnson JR, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R, Stertz S, García-Sastre A, Chanda SK. PMID: 26651948; PMCID: PMC4829074.
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PubMed Mentions:
504 Fields:
Translation:
HumansAnimalsCells
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CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing. Cell Host Microbe. 2015 Nov 11; 18(5):560-70.
Pak V, Eifler TT, Jäger S, Krogan NJ, Fujinaga K, Peterlin BM. PMID: 26567509; PMCID: PMC4648707.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Discovery and functional characterization of a neomorphic PTEN mutation. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):13976-81.
Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee MC, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD. PMID: 26504226; PMCID: PMC4653168.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015 Oct; 21(10):1154-62.
Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. PMID: 26390242; PMCID: PMC4598295.
View in:
PubMed Mentions:
218 Fields:
Translation:
HumansAnimalsCells
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Prediction of Functionally Important Phospho-Regulatory Events in Xenopus laevis Oocytes. PLoS Comput Biol. 2015 Aug; 11(8):e1004362.
Johnson JR, Santos SD, Johnson T, Pieper U, Strumillo M, Wagih O, Sali A, Krogan NJ, Beltrao P. PMID: 26312481; PMCID: PMC4552029.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells. Cell Syst. 2015 Aug 26; 1(2):141-51.
Ding L, Paszkowski-Rogacz M, Winzi M, Chakraborty D, Theis M, Singh S, Ciotta G, Poser I, Roguev A, Chu WK, Choudhary C, Mann M, Stewart AF, Krogan N, Buchholz F. PMID: 27135800; PMCID: PMC5023010.
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PubMed Mentions:
8 Fields:
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Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife. 2015 Aug 22; 4.
Kodani A, Yu TW, Johnson JR, Jayaraman D, Johnson TL, Al-Gazali L, Sztriha L, Partlow JN, Kim H, Krup AL, Dammermann A, Krogan NJ, Walsh CA, Reiter JF. PMID: 26297806; PMCID: PMC4574112.
View in:
PubMed Mentions:
69 Fields:
Translation:
HumansCells
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Comparative mapping of host-pathogen protein-protein interactions. Curr Opin Microbiol. 2015 Oct; 27:62-8.
Shah PS, Wojcechowskyj JA, Eckhardt M, Krogan NJ. PMID: 26275922; PMCID: PMC4659747.
View in:
PubMed Mentions:
23 Fields:
Translation:
Humans
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Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1. Biochemistry. 2015 Jul 28; 54(29):4423-6.
Mark KG, Meza-Gutierrez F, Johnson JR, Newton BW, Krogan NJ, Toczyski DP. PMID: 26161950; PMCID: PMC4816488.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection. Cell Host Microbe. 2015 Jul 08; 18(1):109-21.
Mirrashidi KM, Elwell CA, Verschueren E, Johnson JR, Frando A, Von Dollen J, Rosenberg O, Gulbahce N, Jang G, Johnson T, Jäger S, Gopalakrishnan AM, Sherry J, Dunn JD, Olive A, Penn B, Shales M, Cox JS, Starnbach MN, Derre I, Valdivia R, Krogan NJ, Engel J. PMID: 26118995; PMCID: PMC4540348.
View in:
PubMed Mentions:
106 Fields:
Translation:
HumansCells
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View in:
PubMed Mentions:
60 Fields:
Translation:
HumansCells
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Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity. Cell Rep. 2015 May 26; 11(8):1236-50.
Kane JR, Stanley DJ, Hultquist JF, Johnson JR, Mietrach N, Binning JM, Jónsson SR, Barelier S, Newton BW, Johnson TL, Franks-Skiba KE, Li M, Brown WL, Gunnarsson HI, Adalbjornsdóttir A, Fraser JS, Harris RS, Andrésdóttir V, Gross JD, Krogan NJ. PMID: 25981045; PMCID: PMC4613747.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining. Mol Cell Biol. 2015 Jul; 35(14):2448-63.
Jessulat M, Malty RH, Nguyen-Tran DH, Deineko V, Aoki H, Vlasblom J, Omidi K, Jin K, Minic Z, Hooshyar M, Burnside D, Samanfar B, Phanse S, Freywald T, Prasad B, Zhang Z, Vizeacoumar F, Krogan NJ, Freywald A, Golshani A, Babu M. PMID: 25963654; PMCID: PMC4475915.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Differential genetic interactions of yeast stress response MAPK pathways. Mol Syst Biol. 2015 Apr 17; 11(4):800.
Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. PMID: 25888283; PMCID: PMC4422557.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314.
Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. PMID: 25875391; PMCID: PMC4426669.
View in:
PubMed Mentions:
127 Fields:
Translation:
HumansCells
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NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer. Cell Rep. 2015 Apr 07; 11(1):98-110.
Blakely CM, Pazarentzos E, Olivas V, Asthana S, Yan JJ, Tan I, Hrustanovic G, Chan E, Lin L, Neel DS, Newton W, Bobb KL, Fouts TR, Meshulam J, Gubens MA, Jablons DM, Johnson JR, Bandyopadhyay S, Krogan NJ, Bivona TG. PMID: 25843712; PMCID: PMC4394036.
View in:
PubMed Mentions:
100 Fields:
Translation:
HumansCells
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Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast. PLoS Genet. 2015 Mar; 11(3):e1005074.
Patrick KL, Ryan CJ, Xu J, Lipp JJ, Nissen KE, Roguev A, Shales M, Krogan NJ, Guthrie C. PMID: 25825871; PMCID: PMC4380400.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants. G3 (Bethesda). 2015 Mar 19; 5(5):953-62.
Sánchez A, Roguev A, Krogan NJ, Russell P. PMID: 25795664; PMCID: PMC4426379.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
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Scoring Large-Scale Affinity Purification Mass Spectrometry Datasets with MiST. Curr Protoc Bioinformatics. 2015 Mar 09; 49:8.19.1-8.19.16.
Verschueren E, Von Dollen J, Cimermancic P, Gulbahce N, Sali A, Krogan NJ. PMID: 25754993; PMCID: PMC4378866.
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PubMed Mentions:
26 Fields:
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A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. Mol Cell. 2015 Jan 22; 57(2):329-340.
Ramage HR, Kumar GR, Verschueren E, Johnson JR, Von Dollen J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M. PMID: 25616068; PMCID: PMC4305532.
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PubMed Mentions:
77 Fields:
Translation:
HumansCells
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Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr. Virology. 2015 Mar; 477:10-17.
DePaula-Silva AB, Cassiday PA, Chumley J, Bosque A, Monteiro-Filho CMR, Mahon CS, Cone KR, Krogan N, Elde NC, Planelles V. PMID: 25618414; PMCID: PMC4455942.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Mol Cell. 2015 Jan 22; 57(2):349-60.
Davis ZH, Verschueren E, Jang GM, Kleffman K, Johnson JR, Park J, Von Dollen J, Maher MC, Johnson T, Newton W, Jäger S, Shales M, Horner J, Hernandez RD, Krogan NJ, Glaunsinger BA. PMID: 25544563; PMCID: PMC4305015.
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PubMed Mentions:
120 Fields:
Translation:
HumansCells
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Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discov. 2015 02; 5(2):154-67.
Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakhshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S. PMID: 25501949; PMCID: PMC4407699.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling. Genes Dev. 2014 Nov 15; 28(22):2547-63.
Lin C, Yao E, Wang K, Nozawa Y, Shimizu H, Johnson JR, Chen JN, Krogan NJ, Chuang PT. PMID: 25403183; PMCID: PMC4233246.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts. Mol Cell Biol. 2015 Jan; 35(2):468-78.
Eifler TT, Shao W, Bartholomeeusen K, Fujinaga K, Jäger S, Johnson JR, Luo Z, Krogan NJ, Peterlin BM. PMID: 25384976; PMCID: PMC4272423.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1. Mol Cell Proteomics. 2015 Jan; 14(1):162-76.
Downey M, Johnson JR, Davey NE, Newton BW, Johnson TL, Galaang S, Seller CA, Krogan N, Toczyski DP. PMID: 25381059; PMCID: PMC4288252.
View in:
PubMed Mentions:
40 Fields:
Translation:
Cells
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Cullin E3 ligases and their rewiring by viral factors. Biomolecules. 2014 Oct 13; 4(4):897-930.
Mahon C, Krogan NJ, Craik CS, Pick E. PMID: 25314029; PMCID: PMC4279162.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells. Genome Med. 2014; 6(9):68.
Tosti E, Katakowski JA, Schaetzlein S, Kim HS, Ryan CJ, Shales M, Roguev A, Krogan NJ, Palliser D, Keogh MC, Edelmann W. PMID: 25302077; PMCID: PMC4189729.
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PubMed Mentions:
7 Fields:
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Quantitative analysis of triple-mutant genetic interactions. Nat Protoc. 2014 Aug; 9(8):1867-81.
Braberg H, Alexander R, Shales M, Xu J, Franks-Skiba KE, Wu Q, Haber JE, Krogan NJ. PMID: 25010907; PMCID: PMC4167031.
View in:
PubMed Mentions:
11 Fields:
Translation:
Animals
-
Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. EMBO Rep. 2014 Aug; 15(8):894-902.
Anver S, Roguev A, Zofall M, Krogan NJ, Grewal SI, Harmer SL. PMID: 24957674; PMCID: PMC4197047.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Genetic interaction analysis of point mutations enables interrogation of gene function at a residue-level resolution: exploring the applications of high-resolution genetic interaction mapping of point mutations. Bioessays. 2014 Jul; 36(7):706-13.
Braberg H, Moehle EA, Shales M, Guthrie C, Krogan NJ. PMID: 24842270; PMCID: PMC4289610.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae. G3 (Bethesda). 2014 Apr 02; 4(6):1059-69.
Leung GP, Aristizabal MJ, Krogan NJ, Kobor MS. PMID: 24700328; PMCID: PMC4065249.
View in:
PubMed Mentions:
7 Fields:
-
Adventures in time and space: splicing efficiency and RNA polymerase II elongation rate. RNA Biol. 2014; 11(4):313-9.
Moehle EA, Braberg H, Krogan NJ, Guthrie C. PMID: 24717535; PMCID: PMC4075515.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function. Cell Rep. 2014 Mar 13; 6(5):892-905.
Kim HS, Mukhopadhyay R, Rothbart SB, Silva AC, Vanoosthuyse V, Radovani E, Kislinger T, Roguev A, Ryan CJ, Xu J, Jahari H, Hardwick KG, Greenblatt JF, Krogan NJ, Fillingham JS, Strahl BD, Bouhassira EE, Edelmann W, Keogh MC. PMID: 24565511; PMCID: PMC3969266.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability. PLoS Genet. 2014 Jan; 10(1):e1004140.
Kriegenburg F, Jakopec V, Poulsen EG, Nielsen SV, Roguev A, Krogan N, Gordon C, Fleig U, Hartmann-Petersen R. PMID: 24497846; PMCID: PMC3907333.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
-
Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons. Epigenetics. 2014 Apr; 9(4):513-22.
Martín GM, King DA, Green EM, Garcia-Nieto PE, Alexander R, Collins SR, Krogan NJ, Gozani OP, Morrison AJ. PMID: 24442241; PMCID: PMC4121362.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
A Pil1-Sle1-Syj1-Tax4 functional pathway links eisosomes with PI(4,5)P2 regulation. J Cell Sci. 2014 Mar 15; 127(Pt 6):1318-26.
Kabeche R, Roguev A, Krogan NJ, Moseley JB. PMID: 24434583; PMCID: PMC3953819.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):E15-24.
Lu H, Li Z, Xue Y, Schulze-Gahmen U, Johnson JR, Krogan NJ, Alber T, Zhou Q. PMID: 24367103; PMCID: PMC3890890.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansCells
-
Evolution and functional cross-talk of protein post-translational modifications. Mol Syst Biol. 2013; 9:714.
Beltrao P, Bork P, Krogan NJ, van Noort V. PMID: 24366814; PMCID: PMC4019982.
View in:
PubMed Mentions:
124 Fields:
Translation:
Cells
-
IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science. 2014 Jan 24; 343(6169):428-32.
Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC. PMID: 24356113; PMCID: PMC3976200.
View in:
PubMed Mentions:
267 Fields:
Translation:
HumansCells
-
Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. Cell Rep. 2013 Dec 26; 5(6):1725-36.
Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat KM. PMID: 24360963; PMCID: PMC4007695.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
High-resolution network biology: connecting sequence with function. Nat Rev Genet. 2013 Dec; 14(12):865-79.
Ryan CJ, Cimermancic P, Szpiech ZA, Sali A, Hernandez RD, Krogan NJ. PMID: 24197012; PMCID: PMC4023809.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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The prefoldin complex regulates chromatin dynamics during transcription elongation. PLoS Genet. 2013; 9(9):e1003776.
Millán-Zambrano G, Rodríguez-Gil A, Peñate X, de Miguel-Jiménez L, Morillo-Huesca M, Krogan N, Chávez S. PMID: 24068951; PMCID: PMC3777993.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8. PLoS Genet. 2013 Aug; 9(8):e1003758.
Aristizabal MJ, Negri GL, Benschop JJ, Holstege FC, Krogan NJ, Kobor MS. PMID: 24009531; PMCID: PMC3757075.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II. Cell. 2013 Aug 15; 154(4):775-88.
Braberg H, Jin H, Moehle EA, Chan YA, Wang S, Shales M, Benschop JJ, Morris JH, Qiu C, Hu F, Tang LK, Fraser JS, Holstege FC, Hieter P, Guthrie C, Kaplan CD, Krogan NJ. PMID: 23932120; PMCID: PMC3932829.
View in:
PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
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A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Mol Cell. 2013 Aug 22; 51(4):519-30.
Surma MA, Klose C, Peng D, Shales M, Mrejen C, Stefanko A, Braberg H, Gordon DE, Vorkel D, Ejsing CS, Farese R, Simons K, Krogan NJ, Ernst R. PMID: 23891562; PMCID: PMC3791312.
View in:
PubMed Mentions:
68 Fields:
Translation:
AnimalsCells
-
Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nat Methods. 2013 Jul; 10(7):676-82.
Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. PMID: 23749301; PMCID: PMC3868471.
View in:
PubMed Mentions:
298 Fields:
Translation:
AnimalsCells
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Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation. Cell Rep. 2013 Jun 27; 3(6):2168-78.
Haber JE, Braberg H, Wu Q, Alexander R, Haase J, Ryan C, Lipkin-Moore Z, Franks-Skiba KE, Johnson T, Shales M, Lenstra TL, Holstege FC, Johnson JR, Bloom K, Krogan NJ. PMID: 23746449; PMCID: PMC3718395.
View in:
PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Bringing it all together: big data and HIV research. AIDS. 2013 Mar 13; 27(5):835-8.
Bushman FD, Barton S, Bailey A, Greig C, Malani N, Bandyopadhyay S, Young J, Chanda S, Krogan N. PMID: 23719353; PMCID: PMC3671485.
View in:
PubMed Mentions:
8 Fields:
Translation:
Humans
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The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat. Elife. 2013 Mar 05; 2:e00327.
Schulze-Gahmen U, Upton H, Birnberg A, Bao K, Chou S, Krogan NJ, Zhou Q, Alber T. PMID: 23471103; PMCID: PMC3589825.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Quantitative genetic-interaction mapping in mammalian cells. Nat Methods. 2013 May; 10(5):432-7.
Roguev A, Talbot D, Negri GL, Shales M, Cagney G, Bandyopadhyay S, Panning B, Krogan NJ. PMID: 23407553; PMCID: PMC3641890.
View in:
PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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From systems to structure: bridging networks and mechanism. Mol Cell. 2013 Jan 24; 49(2):222-31.
Fraser JS, Gross JD, Krogan NJ. PMID: 23352243; PMCID: PMC3558917.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
-
CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Mol Cell. 2013 Feb 21; 49(4):632-44.
Kim DY, Kwon E, Hartley PD, Crosby DC, Mann S, Krogan NJ, Gross JD. PMID: 23333304; PMCID: PMC3582769.
View in:
PubMed Mentions:
75 Fields:
Translation:
HumansCells
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Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F. J Mol Biol. 2013 Apr 12; 425(7):1172-82.
Albin JS, Anderson JS, Johnson JR, Harjes E, Matsuo H, Krogan NJ, Harris RS. PMID: 23318957; PMCID: PMC3602375.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
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A gene ontology inferred from molecular networks. Nat Biotechnol. 2013 Jan; 31(1):38-45.
Dutkowski J, Kramer M, Surma MA, Balakrishnan R, Cherry JM, Krogan NJ, Ideker T. PMID: 23242164; PMCID: PMC3654867.
View in:
PubMed Mentions:
105 Fields:
Translation:
Animals
-
All or nothing: protein complexes flip essentiality between distantly related eukaryotes. Genome Biol Evol. 2013; 5(6):1049-59.
Ryan CJ, Krogan NJ, Cunningham P, Cagney G. PMID: 23661563; PMCID: PMC3698920.
View in:
PubMed Mentions:
16 Fields:
Translation:
Animals
-
Dissection of DNA damage responses using multiconditional genetic interaction maps. Mol Cell. 2013 Jan 24; 49(2):346-58.
Guénolé A, Srivas R, Vreeken K, Wang ZZ, Wang S, Krogan NJ, Ideker T, van Attikum H. PMID: 23273983; PMCID: PMC3633480.
View in:
PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
-
Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. PLoS Pathog. 2012 Dec; 8(12):e1003085.
Stanley DJ, Bartholomeeusen K, Crosby DC, Kim DY, Kwon E, Yen L, Cartozo NC, Li M, Jäger S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan NJ, Harris RS, Peterlin BM, Gross JD. PMID: 23300442; PMCID: PMC3531493.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
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HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):E123-31.
Chou S, Upton H, Bao K, Schulze-Gahmen U, Samelson AJ, He N, Nowak A, Lu H, Krogan NJ, Zhou Q, Alber T. PMID: 23251033; PMCID: PMC3545800.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansCells
-
The yeast SR-like protein Npl3 links chromatin modification to mRNA processing. PLoS Genet. 2012; 8(11):e1003101.
Moehle EA, Ryan CJ, Krogan NJ, Kress TL, Guthrie C. PMID: 23209445; PMCID: PMC3510044.
View in:
PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012 Dec; 44(12):1302-9.
Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. PMID: 23104007; PMCID: PMC3510335.
View in:
PubMed Mentions:
141 Fields:
Translation:
HumansAnimalsCells
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Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant. Mol Cell Biol. 2012 Nov; 32(21):4445-54.
Sánchez A, Sharma S, Rozenzhak S, Roguev A, Krogan NJ, Chabes A, Russell P. PMID: 22927644; PMCID: PMC3486156.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
-
Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20; 150(2):413-25.
Beltrao P, Albanèse V, Kenner LR, Swaney DL, Burlingame A, Villén J, Lim WA, Fraser JS, Frydman J, Krogan NJ. PMID: 22817900; PMCID: PMC3404735.
View in:
PubMed Mentions:
202 Fields:
Translation:
HumansAnimalsCells
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Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles. J Virol. 2012 Oct; 86(19):10517-23.
Lu C, Luo Z, Jäger S, Krogan NJ, Peterlin BM. PMID: 22811528; PMCID: PMC3457264.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell. 2012 Jun 08; 46(5):691-704.
Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ. PMID: 22681890; PMCID: PMC3380636.
View in:
PubMed Mentions:
116 Fields:
Translation:
Animals
-
Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet. 2012; 8(3):e1002576.
Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M, Krogan N, Ren B, Song JS, Reiter JF. PMID: 22438827; PMCID: PMC3305387.
View in:
PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
-
Differential network biology. Mol Syst Biol. 2012 Jan 17; 8:565.
Ideker T, Krogan NJ. PMID: 22252388; PMCID: PMC3296360.
View in:
PubMed Mentions:
326 Fields:
Translation:
HumansAnimals
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First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G. ACS Chem Biol. 2012 Mar 16; 7(3):506-17.
Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, Schiffer CA, Harris RS. PMID: 22181350; PMCID: PMC3306499.
View in:
PubMed Mentions:
80 Fields:
Translation:
HumansCells
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Comparative interaction networks: bridging genotype to phenotype. Adv Exp Med Biol. 2012; 751:139-56.
Beltrao P, Ryan C, Krogan NJ. PMID: 22821457; PMCID: PMC3518490.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature. 2011 Dec 21; 481(7381):371-5.
Jäger S, Kim DY, Hultquist JF, Shindo K, LaRue RS, Kwon E, Li M, Anderson BD, Yen L, Stanley D, Mahon C, Kane J, Franks-Skiba K, Cimermancic P, Burlingame A, Sali A, Craik CS, Harris RS, Gross JD, Krogan NJ. PMID: 22190037; PMCID: PMC3310910.
View in:
PubMed Mentions:
224 Fields:
Translation:
HumansAnimalsCells
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Global landscape of HIV-human protein complexes. Nature. 2011 Dec 21; 481(7381):365-70.
Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ. PMID: 22190034; PMCID: PMC3310911.
View in:
PubMed Mentions:
392 Fields:
Translation:
HumansCells
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Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. Mol Cell Proteomics. 2012 Apr; 11(4):M111.015313.
Naji S, Ambrus G, Cimermancic P, Reyes JR, Johnson JR, Filbrandt R, Huber MD, Vesely P, Krogan NJ, Yates JR, Saphire AC, Gerace L. PMID: 22174317; PMCID: PMC3322577.
View in:
PubMed Mentions:
78 Fields:
Translation:
HumansCells
-
RNA polymerase II carboxyl-terminal domain phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36. J Biol Chem. 2012 Jan 27; 287(5):3249-56.
Fuchs SM, Kizer KO, Braberg H, Krogan NJ, Strahl BD. PMID: 22157004; PMCID: PMC3270979.
View in:
PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
-
Eisosome proteins assemble into a membrane scaffold. J Cell Biol. 2011 Nov 28; 195(5):889-902.
Karotki L, Huiskonen JT, Stefan CJ, Ziólkowska NE, Roth R, Surma MA, Krogan NJ, Emr SD, Heuser J, Grünewald K, Walther TC. PMID: 22123866; PMCID: PMC3257569.
View in:
PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
-
Distinct configurations of protein complexes and biochemical pathways revealed by epistatic interaction network motifs. BMC Syst Biol. 2011 Aug 22; 5:133.
Casey F, Krogan N, Shields DC, Cagney G. PMID: 21859460; PMCID: PMC3176491.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Key functional regions in the histone variant H2A.Z C-terminal docking domain. Mol Cell Biol. 2011 Sep; 31(18):3871-84.
Wang AY, Aristizabal MJ, Ryan C, Krogan NJ, Kobor MS. PMID: 21791612; PMCID: PMC3165728.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data. BMC Bioinformatics. 2011 Jul 22; 12:298.
Fahey ME, Bennett MJ, Mahon C, Jäger S, Pache L, Kumar D, Shapiro A, Rao K, Chanda SK, Craik CS, Frankel AD, Krogan NJ. PMID: 21777475; PMCID: PMC3213248.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10620-5.
Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ. PMID: 21673141; PMCID: PMC3127919.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Improved functional overview of protein complexes using inferred epistatic relationships. BMC Syst Biol. 2011 May 23; 5:80.
Ryan C, Greene D, Guénolé A, van Attikum H, Krogan NJ, Cunningham P, Cagney G. PMID: 21605386; PMCID: PMC3117733.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol. 2011 Jun; 13(6):715-21.
Temkin P, Lauffer B, Jäger S, Cimermancic P, Krogan NJ, von Zastrow M. PMID: 21602791; PMCID: PMC3113693.
View in:
PubMed Mentions:
269 Fields:
Translation:
HumansCells
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Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol Cell. 2011 Apr 22; 42(2):160-71.
Stewart EV, Nwosu CC, Tong Z, Roguev A, Cummins TD, Kim DU, Hayles J, Park HO, Hoe KL, Powell DW, Krogan NJ, Espenshade PJ. PMID: 21504829; PMCID: PMC3083633.
View in:
PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
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Imputing and predicting quantitative genetic interactions in epistatic MAPs. Methods Mol Biol. 2011; 781:353-61.
Ryan C, Cagney G, Krogan N, Cunningham P, Greene D. PMID: 21877290; PMCID: PMC3376077.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Phenotypic landscape of a bacterial cell. Cell. 2011 Jan 07; 144(1):143-56.
Nichols RJ, Sen S, Choo YJ, Beltrao P, Zietek M, Chaba R, Lee S, Kazmierczak KM, Lee KJ, Wong A, Shales M, Lovett S, Winkler ME, Krogan NJ, Typas A, Gross CA. PMID: 21185072; PMCID: PMC3060659.
View in:
PubMed Mentions:
355 Fields:
Translation:
Cells
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Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21; 6:451.
Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. PMID: 21179023; PMCID: PMC3018166.
View in:
PubMed Mentions:
80 Fields:
Translation:
HumansAnimals
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Functional overlap and regulatory links shape genetic interactions between signaling pathways. Cell. 2010 Dec 10; 143(6):991-1004.
van Wageningen S, Kemmeren P, Lijnzaad P, Margaritis T, Benschop JJ, de Castro IJ, van Leenen D, Groot Koerkamp MJ, Ko CW, Miles AJ, Brabers N, Brok MO, Lenstra TL, Fiedler D, Fokkens L, Aldecoa R, Apweiler E, Taliadouros V, Sameith K, van de Pasch LA, van Hooff SR, Bakker LV, Krogan NJ, Snel B, Holstege FC. PMID: 21145464; PMCID: PMC3073509.
View in:
PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
-
Rewiring of genetic networks in response to DNA damage. Science. 2010 Dec 03; 330(6009):1385-9.
Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guénolé A, van Attikum H, Shokat KM, Kolodner RD, Huh WK, Aebersold R, Keogh MC, Krogan NJ, Ideker T. PMID: 21127252; PMCID: PMC3006187.
View in:
PubMed Mentions:
234 Fields:
Translation:
AnimalsCells
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Individual lysine acetylations on the N terminus of Saccharomyces cerevisiae H2A.Z are highly but not differentially regulated. J Biol Chem. 2010 Dec 17; 285(51):39855-65.
Mehta M, Braberg H, Wang S, Lozsa A, Shales M, Solache A, Krogan NJ, Keogh MC. PMID: 20952395; PMCID: PMC3000967.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol. 2010 Oct 05; 6:420.
Zheng J, Benschop JJ, Shales M, Kemmeren P, Greenblatt J, Cagney G, Holstege F, Li H, Krogan NJ. PMID: 20959818; PMCID: PMC2990640.
View in:
PubMed Mentions:
35 Fields:
Translation:
Animals
-
Purification and characterization of HIV-human protein complexes. Methods. 2011 Jan; 53(1):13-9.
Jäger S, Gulbahce N, Cimermancic P, Kane J, He N, Chou S, D'Orso I, Fernandes J, Jang G, Frankel AD, Alber T, Zhou Q, Krogan NJ. PMID: 20708689; PMCID: PMC3076283.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
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A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol. 2010 Jun 08; 6:377.
Lefebvre C, Rajbhandari P, Alvarez MJ, Bandaru P, Lim WK, Sato M, Wang K, Sumazin P, Kustagi M, Bisikirska BC, Basso K, Beltrao P, Krogan N, Gautier J, Dalla-Favera R, Califano A. PMID: 20531406; PMCID: PMC2913282.
View in:
PubMed Mentions:
209 Fields:
Translation:
HumansCells
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A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nat Struct Mol Biol. 2010 Jul; 17(7):901-8.
Aguilar PS, Fröhlich F, Rehman M, Shales M, Ulitsky I, Olivera-Couto A, Braberg H, Shamir R, Walter P, Mann M, Ejsing CS, Krogan NJ, Walther TC. PMID: 20526336; PMCID: PMC3073498.
View in:
PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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Quantitative genetic interactions reveal biological modularity. Cell. 2010 May 28; 141(5):739-45.
Beltrao P, Cagney G, Krogan NJ. PMID: 20510918; PMCID: PMC2946632.
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PubMed Mentions:
81 Fields:
Translation:
HumansAnimals
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HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. Mol Cell. 2010 May 14; 38(3):428-38.
He N, Liu M, Hsu J, Xue Y, Chou S, Burlingame A, Krogan NJ, Alber T, Zhou Q. PMID: 20471948; PMCID: PMC3085314.
View in:
PubMed Mentions:
253 Fields:
Translation:
HumansCells
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The next frontier of systems biology: higher-order and interspecies interactions. Genome Biol. 2010; 11(5):208.
Fischbach MA, Krogan NJ. PMID: 20441613; PMCID: PMC2898071.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Quantitative genetic interaction mapping using the E-MAP approach. Methods Enzymol. 2010; 470:205-31.
Collins SR, Roguev A, Krogan NJ. PMID: 20946812; PMCID: PMC2957675.
View in:
PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010 Feb 05; 6(2):153-66.
Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, Krogan NJ, Reiter JF, Stanford WL. PMID: 20144788; PMCID: PMC2849004.
View in:
PubMed Mentions:
95 Fields:
Translation:
AnimalsCells
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HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic. 2010 Jan; 11(1):110-22.
Lenassi M, Cagney G, Liao M, Vaupotic T, Bartholomeeusen K, Cheng Y, Krogan NJ, Plemenitas A, Peterlin BM. PMID: 19912576; PMCID: PMC2796297.
View in:
PubMed Mentions:
295 Fields:
Translation:
HumansCells
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Genome-wide association data reveal a global map of genetic interactions among protein complexes. PLoS Genet. 2009 Dec; 5(12):e1000782.
Hannum G, Srivas R, Guénolé A, van Attikum H, Krogan NJ, Karp RM, Ideker T. PMID: 20041197; PMCID: PMC2788232.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Towards accurate imputation of quantitative genetic interactions. Genome Biol. 2009; 10(12):R140.
Ulitsky I, Krogan NJ, Shamir R. PMID: 20003301; PMCID: PMC2812947.
View in:
PubMed Mentions:
11 Fields:
Translation:
Animals
-
An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe. Nat Struct Mol Biol. 2009 Dec; 16(12):1286-93.
Kim HS, Vanoosthuyse V, Fillingham J, Roguev A, Watt S, Kislinger T, Treyer A, Carpenter LR, Bennett CS, Emili A, Greenblatt JF, Hardwick KG, Krogan NJ, Bähler J, Keogh MC. PMID: 19915592; PMCID: PMC2788674.
View in:
PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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From information to knowledge: new technologies for defining gene function. Nat Methods. 2009 Oct; 6(10):721-23.
Collins SR, Weissman JS, Krogan NJ. PMID: 19953683; PMCID: PMC3066030.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300. RNA. 2009 Dec; 15(12):2174-85.
Khanna M, Van Bakel H, Tang X, Calarco JA, Babak T, Guo G, Emili A, Greenblatt JF, Hughes TR, Krogan NJ, Blencowe BJ. PMID: 19789211; PMCID: PMC2779666.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell. Mol Syst Biol. 2009; 5:275.
Gong Y, Kakihara Y, Krogan N, Greenblatt J, Emili A, Zhang Z, Houry WA. PMID: 19536198; PMCID: PMC2710862.
View in:
PubMed Mentions:
114 Fields:
Translation:
Cells
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Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol. 2009 Jun 16; 7(6):e1000134.
Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim WA, Shokat KM, Burlingame AL, Krogan NJ. PMID: 19547744; PMCID: PMC2691599.
View in:
PubMed Mentions:
112 Fields:
Translation:
AnimalsCells
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Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog. 2009 May; 5(5):e1000437.
Bushman FD, Malani N, Fernandes J, D'Orso I, Cagney G, Diamond TL, Zhou H, Hazuda DJ, Espeseth AS, König R, Bandyopadhyay S, Ideker T, Goff SP, Krogan NJ, Frankel AD, Young JA, Chanda SK. PMID: 19478882; PMCID: PMC2682202.
View in:
PubMed Mentions:
265 Fields:
Translation:
HumansCells
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An rtt109-independent role for vps75 in transcription-associated nucleosome dynamics. Mol Cell Biol. 2009 Aug; 29(15):4220-34.
Selth LA, Lorch Y, Ocampo-Hafalla MT, Mitter R, Shales M, Krogan NJ, Kornberg RD, Svejstrup JQ. PMID: 19470761; PMCID: PMC2715805.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle. J Biol Chem. 2009 May 29; 284(22):15233-45.
Wiseman RL, Chin KT, Haynes CM, Stanhill A, Xu CF, Roguev A, Krogan NJ, Neubert TA, Ron D. PMID: 19349280; PMCID: PMC2685704.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Functional organization of the S. cerevisiae phosphorylation network. Cell. 2009 Mar 06; 136(5):952-63.
Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, Shokat KM, Krogan NJ. PMID: 19269370; PMCID: PMC2856666.
View in:
PubMed Mentions:
161 Fields:
Translation:
AnimalsCells
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Learning a prior on regulatory potential from eQTL data. PLoS Genet. 2009 Jan; 5(1):e1000358.
Lee SI, Dudley AM, Drubin D, Silver PA, Krogan NJ, Pe'er D, Koller D. PMID: 19180192; PMCID: PMC2627940.
View in:
PubMed Mentions:
124 Fields:
Translation:
HumansAnimals
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A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics. 2009 Jun; 8(6):1361-81.
Wang H, Kakaradov B, Collins SR, Karotki L, Fiedler D, Shales M, Shokat KM, Walther TC, Krogan NJ, Koller D. PMID: 19176519; PMCID: PMC2690481.
View in:
PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry. Methods Mol Biol. 2009; 548:187-207.
Babu M, Krogan NJ, Awrey DE, Emili A, Greenblatt JF. PMID: 19521826.
View in:
PubMed Mentions:
16 Fields:
Translation:
Animals
-
A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast. Mol Cell. 2008 Dec 05; 32(5):727-34.
Kress TL, Krogan NJ, Guthrie C. PMID: 19061647; PMCID: PMC2677966.
View in:
PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
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A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell. 2008 Dec 05; 32(5):735-46.
Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ. PMID: 19061648; PMCID: PMC2644724.
View in:
PubMed Mentions:
162 Fields:
Translation:
AnimalsCells
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Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol. 2008; 9(11):R167.
Shevchenko A, Roguev A, Schaft D, Buchanan L, Habermann B, Sakalar C, Thomas H, Krogan NJ, Shevchenko A, Stewart AF. PMID: 19040720; PMCID: PMC2614481.
View in:
PubMed Mentions:
80 Fields:
Translation:
Animals
-
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase. Science. 2008 Oct 24; 322(5901):597-602.
Nagai S, Dubrana K, Tsai-Pflugfelder M, Davidson MB, Roberts TM, Brown GW, Varela E, Hediger F, Gasser SM, Krogan NJ. PMID: 18948542; PMCID: PMC3518492.
View in:
PubMed Mentions:
231 Fields:
Translation:
AnimalsCells
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Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science. 2008 Oct 17; 322(5900):405-10.
Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman JS, Krogan NJ. PMID: 18818364; PMCID: PMC2753251.
View in:
PubMed Mentions:
212 Fields:
Translation:
AnimalsCells
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Optimal stepwise experimental design for pairwise functional interaction studies. Bioinformatics. 2008 Dec 01; 24(23):2733-9.
Casey FP, Cagney G, Krogan NJ, Shields DC. PMID: 18805797; PMCID: PMC3493128.
View in:
PubMed Mentions:
8 Fields:
-
High-throughput, quantitative analyses of genetic interactions in E. coli. Nat Methods. 2008 Sep; 5(9):781-7.
Typas A, Nichols RJ, Siegele DA, Shales M, Collins SR, Lim B, Braberg H, Yamamoto N, Takeuchi R, Wanner BL, Mori H, Weissman JS, Krogan NJ, Gross CA. PMID: 19160513; PMCID: PMC2700713.
View in:
PubMed Mentions:
128 Fields:
Translation:
Cells
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A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods. 2008 Aug; 5(8):711-8.
Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS. PMID: 18622397; PMCID: PMC2756093.
View in:
PubMed Mentions:
294 Fields:
Translation:
Animals
-
Ensemble non-negative matrix factorization methods for clustering protein-protein interactions. Bioinformatics. 2008 Aug 01; 24(15):1722-8.
Greene D, Cagney G, Krogan N, Cunningham P. PMID: 18556670; PMCID: PMC3493126.
View in:
PubMed Mentions:
16 Fields:
Translation:
Cells
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Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Mol Cell Biol. 2008 Jul; 28(13):4342-53.
Fillingham J, Recht J, Silva AC, Suter B, Emili A, Stagljar I, Krogan NJ, Allis CD, Keogh MC, Greenblatt JF. PMID: 18458063; PMCID: PMC2447148.
View in:
PubMed Mentions:
120 Fields:
Translation:
AnimalsCells
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BAC to the future: functional genomics in mammals. Nat Methods. 2008 May; 5(5):383-4.
Roguev A, Krogan NJ. PMID: 18446155; PMCID: PMC3380627.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Functional maps of protein complexes from quantitative genetic interaction data. PLoS Comput Biol. 2008 Apr 18; 4(4):e1000065.
Bandyopadhyay S, Kelley R, Krogan NJ, Ideker T. PMID: 18421374; PMCID: PMC2289880.
View in:
PubMed Mentions:
82 Fields:
Translation:
Cells
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High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe. Nat Methods. 2007 Oct; 4(10):861-6.
Roguev A, Wiren M, Weissman JS, Krogan NJ. PMID: 17893680.
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PubMed Mentions:
95 Fields:
Translation:
Animals
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Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p. BMC Biol. 2007 Sep 19; 5:38.
Suter B, Pogoutse O, Guo X, Krogan N, Lewis P, Greenblatt JF, Rine J, Emili A. PMID: 17880717; PMCID: PMC2140264.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell. 2007 Aug 10; 130(3):499-511.
Morrison AJ, Kim JA, Person MD, Highland J, Xiao J, Wehr TS, Hensley S, Bao Y, Shen J, Collins SR, Weissman JS, Delrow J, Krogan NJ, Haber JE, Shen X. PMID: 17693258.
View in:
PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium. Microbiology (Reading). 2007 Aug; 153(Pt 8):2472-2482.
Zaharik ML, Lamb SS, Baker KE, Krogan NJ, Neuhard J, Kelln RA. PMID: 17660412.
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PubMed Mentions: Fields:
Translation:
Cells
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H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol Cell. 2007 Jul 20; 27(2):275-288.
Wyce A, Xiao T, Whelan KA, Kosman C, Walter W, Eick D, Hughes TR, Krogan NJ, Strahl BD, Berger SL. PMID: 17643376.
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PubMed Mentions:
125 Fields:
Translation:
AnimalsCells
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Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Mol Syst Biol. 2007; 3:116.
Gupta R, Kus B, Fladd C, Wasmuth J, Tonikian R, Sidhu S, Krogan NJ, Parkinson J, Rotin D. PMID: 17551511; PMCID: PMC1911201.
View in:
PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
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SIN-fully silent: HDAC complexes in fission yeast. Nat Struct Mol Biol. 2007 May; 14(5):358-9.
Roguev A, Krogan NJ. PMID: 17473877.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol Syst Biol. 2007; 3:86.
Ihmels J, Collins SR, Schuldiner M, Krogan NJ, Weissman JS. PMID: 17389874; PMCID: PMC1847942.
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PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5836-41.
Laribee RN, Shibata Y, Mersman DP, Collins SR, Kemmeren P, Roguev A, Weissman JS, Briggs SD, Krogan NJ, Strahl BD. PMID: 17389396; PMCID: PMC1851578.
View in:
PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 2007 Apr 12; 446(7137):806-10.
Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ. PMID: 17314980.
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PubMed Mentions:
539 Fields:
Translation:
AnimalsCells
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Investigating the in vivo activity of the DeaD protein using protein-protein interactions and the translational activity of structured chloramphenicol acetyltransferase mRNAs. J Cell Biochem. 2007 Feb 15; 100(3):642-52.
Butland G, Krogan NJ, Xu J, Yang WH, Aoki H, Li JS, Krogan N, Menendez J, Cagney G, Kiani GC, Jessulat MG, Datta N, Ivanov I, Abouhaidar MG, Emili A, Greenblatt J, Ganoza MC, Golshani A. PMID: 16983699.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
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Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Mol Cell Proteomics. 2007 Mar; 6(3):439-50.
Collins SR, Kemmeren P, Zhao XC, Greenblatt JF, Spencer F, Holstege FC, Weissman JS, Krogan NJ. PMID: 17200106.
View in:
PubMed Mentions:
354 Fields:
Translation:
Animals
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Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions. Methods. 2006 Dec; 40(4):344-52.
Schuldiner M, Collins SR, Weissman JS, Krogan NJ. PMID: 17101447.
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PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes. Mol Cell Biol. 2007 Jan; 27(2):721-31.
Xiao T, Shibata Y, Rao B, Laribee RN, O'Rourke R, Buck MJ, Greenblatt JF, Krogan NJ, Lieb JD, Strahl BD. PMID: 17088384; PMCID: PMC1800795.
View in:
PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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GammaH2AX and its role in DNA double-strand break repair. Biochem Cell Biol. 2006 Aug; 84(4):568-77.
Fillingham J, Keogh MC, Krogan NJ. PMID: 16936829.
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PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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PIPE: a protein-protein interaction prediction engine based on the re-occurring short polypeptide sequences between known interacting protein pairs. BMC Bioinformatics. 2006 Jul 27; 7:365.
Pitre S, Dehne F, Chan A, Cheetham J, Duong A, Emili A, Gebbia M, Greenblatt J, Jessulat M, Krogan N, Luo X, Golshani A. PMID: 16872538; PMCID: PMC1557541.
View in:
PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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Signals and systems. Genome Biol. 2006; 7(4):313.
Krogan NJ, Hughes TR. PMID: 16677414; PMCID: PMC1557984.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell. 2006 Mar 24; 124(6):1155-68.
Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D. PMID: 16564010.
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PubMed Mentions:
108 Fields:
Translation:
AnimalsCells
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Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30; 440(7084):637-43.
Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrín-Alvarez JM, Shales M, Zhang X, Davey M, Robinson MD, Paccanaro A, Bray JE, Sheung A, Beattie B, Richards DP, Canadien V, Lalev A, Mena F, Wong P, Starostine A, Canete MM, Vlasblom J, Wu S, Orsi C, Collins SR, Chandran S, Haw R, Rilstone JJ, Gandi K, Thompson NJ, Musso G, St Onge P, Ghanny S, Lam MH, Butland G, Altaf-Ul AM, Kanaya S, Shilatifard A, O'Shea E, Weissman JS, Ingles CJ, Hughes TR, Parkinson J, Gerstein M, Wodak SJ, Emili A, Greenblatt JF. PMID: 16554755.
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PubMed Mentions:
1254 Fields:
Translation:
AnimalsCells
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The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4. Genes Dev. 2006 Mar 15; 20(6):660-5.
Keogh MC, Mennella TA, Sawa C, Berthelet S, Krogan NJ, Wolek A, Podolny V, Carpenter LR, Greenblatt JF, Baetz K, Buratowski S. PMID: 16543219; PMCID: PMC1413285.
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PubMed Mentions:
137 Fields:
Translation:
AnimalsCells
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Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003.
Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. PMID: 16738550; PMCID: PMC1681477.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol. 2006; 7(7):R63.
Collins SR, Schuldiner M, Krogan NJ, Weissman JS. PMID: 16859555; PMCID: PMC1779568.
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PubMed Mentions:
196 Fields:
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Functional genomics of the yeast DNA-damage response. Genome Biol. 2006; 7(9):233.
Cagney G, Alvaro D, Reid RJ, Thorpe PH, Rothstein R, Krogan NJ. PMID: 16959047; PMCID: PMC1794544.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature. 2006 Jan 26; 439(7075):497-501.
Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ. PMID: 16299494.
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PubMed Mentions:
234 Fields:
Translation:
AnimalsCells
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Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell. 2005 Nov 18; 123(4):593-605.
Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ. PMID: 16286008.
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PubMed Mentions:
470 Fields:
Translation:
AnimalsCells
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Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell. 2005 Nov 04; 123(3):507-19.
Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ. PMID: 16269340.
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PubMed Mentions:
479 Fields:
Translation:
AnimalsCells
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Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae. Mol Cell Biol. 2005 Nov; 25(22):10122-35.
Prather D, Krogan NJ, Emili A, Greenblatt JF, Winston F. PMID: 16260625; PMCID: PMC1280281.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Curr Biol. 2005 Aug 23; 15(16):1487-93.
Laribee RN, Krogan NJ, Xiao T, Shibata Y, Hughes TR, Greenblatt JF, Strahl BD. PMID: 16040246.
View in:
PubMed Mentions:
91 Fields:
Translation:
AnimalsCells
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Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol Cell Biol. 2005 Jul; 25(13):5523-34.
Hoang T, Peng WT, Vanrobays E, Krogan N, Hiley S, Beyer AL, Osheim YN, Greenblatt J, Hughes TR, Lafontaine DL. PMID: 15964808; PMCID: PMC1156982.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell. 2005 Mar 11; 120(5):715-27.
Zhao R, Davey M, Hsu YC, Kaplanek P, Tong A, Parsons AB, Krogan N, Cagney G, Mai D, Greenblatt J, Boone C, Emili A, Houry WA. PMID: 15766533.
View in:
PubMed Mentions:
384 Fields:
Translation:
Animals
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Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell. 2005 Feb 18; 17(4):585-94.
Emre NC, Ingvarsdottir K, Wyce A, Wood A, Krogan NJ, Henry KW, Li K, Marmorstein R, Greenblatt JF, Shilatifard A, Berger SL. PMID: 15721261.
View in:
PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
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The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism. J Biol Chem. 2005 May 13; 280(19):19213-20.
Savchenko A, Krogan N, Cort JR, Evdokimova E, Lew JM, Yee AA, Sánchez-Pulido L, Andrade MA, Bochkarev A, Watson JD, Kennedy MA, Greenblatt J, Hughes T, Arrowsmith CH, Rommens JM, Edwards AM. PMID: 15701634.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature. 2005 Feb 03; 433(7025):531-7.
Butland G, Peregrín-Alvarez JM, Li J, Yang W, Yang X, Canadien V, Starostine A, Richards D, Beattie B, Krogan N, Davey M, Parkinson J, Greenblatt J, Emili A. PMID: 15690043.
View in:
PubMed Mentions:
479 Fields:
Translation:
Cells
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H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex. Mol Cell Biol. 2005 Feb; 25(3):1162-72.
Ingvarsdottir K, Krogan NJ, Emre NC, Wyce A, Thompson NJ, Emili A, Hughes TR, Greenblatt JF, Berger SL. PMID: 15657441; PMCID: PMC544016.
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PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
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Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Mol Cell Biol. 2005 Jan; 25(2):637-51.
Xiao T, Kao CF, Krogan NJ, Sun ZW, Greenblatt JF, Osley MA, Strahl BD. PMID: 15632065; PMCID: PMC543430.
View in:
PubMed Mentions:
175 Fields:
Translation:
AnimalsCells
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Proteasome involvement in the repair of DNA double-strand breaks. Mol Cell. 2004 Dec 22; 16(6):1027-34.
Krogan NJ, Lam MH, Fillingham J, Keogh MC, Gebbia M, Li J, Datta N, Cagney G, Buratowski S, Emili A, Greenblatt JF. PMID: 15610744.
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PubMed Mentions:
95 Fields:
Translation:
AnimalsCells
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INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell. 2004 Dec 17; 119(6):767-75.
Morrison AJ, Highland J, Krogan NJ, Arbel-Eden A, Greenblatt JF, Haber JE, Shen X. PMID: 15607974.
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PubMed Mentions:
257 Fields:
Translation:
AnimalsCells
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The functional landscape of mouse gene expression. J Biol. 2004; 3(5):21.
Zhang W, Morris QD, Chang R, Shai O, Bakowski MA, Mitsakakis N, Mohammad N, Robinson MD, Zirngibl R, Somogyi E, Laurin N, Eftekharpour E, Sat E, Grigull J, Pan Q, Peng WT, Krogan N, Greenblatt J, Fehlings M, van der Kooy D, Aubin J, Bruneau BG, Rossant J, Blencowe BJ, Frey BJ, Hughes TR. PMID: 15588312; PMCID: PMC549719.
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PubMed Mentions:
153 Fields:
Translation:
AnimalsCells
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The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature. 2004 Nov 25; 432(7016):517-22.
Kim M, Krogan NJ, Vasiljeva L, Rando OJ, Nedea E, Greenblatt JF, Buratowski S. PMID: 15565157.
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PubMed Mentions:
266 Fields:
Translation:
AnimalsCells
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Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator. J Biol Chem. 2005 Feb 11; 280(6):4299-306.
Kong SE, Kobor MS, Krogan NJ, Somesh BP, Søgaard TM, Greenblatt JF, Svejstrup JQ. PMID: 15563457.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13513-8.
Krogan NJ, Baetz K, Keogh MC, Datta N, Sawa C, Kwok TC, Thompson NJ, Davey MG, Pootoolal J, Hughes TR, Emili A, Buratowski S, Hieter P, Greenblatt JF. PMID: 15353583; PMCID: PMC518788.
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PubMed Mentions:
127 Fields:
Translation:
AnimalsCells
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Exploration of essential gene functions via titratable promoter alleles. Cell. 2004 Jul 09; 118(1):31-44.
Mnaimneh S, Davierwala AP, Haynes J, Moffat J, Peng WT, Zhang W, Yang X, Pootoolal J, Chua G, Lopez A, Trochesset M, Morse D, Krogan NJ, Hiley SL, Li Z, Morris Q, Grigull J, Mitsakakis N, Roberts CJ, Greenblatt JF, Boone C, Kaiser CA, Andrews BJ, Hughes TR. PMID: 15242642.
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PubMed Mentions:
290 Fields:
Translation:
AnimalsCells
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Bromodomain factor 1 (Bdf1) is phosphorylated by protein kinase CK2. Mol Cell Biol. 2004 Jun; 24(11):4734-42.
Sawa C, Nedea E, Krogan N, Wada T, Handa H, Greenblatt J, Buratowski S. PMID: 15143168; PMCID: PMC416403.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Escherichia coli mRNAs with strong Shine/Dalgarno sequences also contain 5' end sequences complementary to domain # 17 on the 16S ribosomal RNA. Biochem Biophys Res Commun. 2004 Apr 16; 316(4):978-83.
Golshani A, Krogan NJ, Xu J, Pacal M, Yang XC, Ivanov I, Providenti MA, Ganoza MC, Ivanov IG, AbouHaidar MG. PMID: 15044080.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. Nucleic Acids Res. 2004; 32(6):1993-9.
Peng WT, Krogan NJ, Richards DP, Greenblatt JF, Hughes TR. PMID: 15056729; PMCID: PMC390369.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Global mapping of the yeast genetic interaction network. Science. 2004 Feb 06; 303(5659):808-13.
Tong AH, Lesage G, Bader GD, Ding H, Xu H, Xin X, Young J, Berriz GF, Brost RL, Chang M, Chen Y, Cheng X, Chua G, Friesen H, Goldberg DS, Haynes J, Humphries C, He G, Hussein S, Ke L, Krogan N, Li Z, Levinson JN, Lu H, Ménard P, Munyana C, Parsons AB, Ryan O, Tonikian R, Roberts T, Sdicu AM, Shapiro J, Sheikh B, Suter B, Wong SL, Zhang LV, Zhu H, Burd CG, Munro S, Sander C, Rine J, Greenblatt J, Peter M, Bretscher A, Bell G, Roth FP, Brown GW, Andrews B, Bussey H, Boone C. PMID: 14764870.
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PubMed Mentions:
950 Fields:
Translation:
HumansAnimalsCells
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The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion. Mol Cell Biol. 2004 Feb; 24(3):1232-44.
Baetz KK, Krogan NJ, Emili A, Greenblatt J, Hieter P. PMID: 14729968; PMCID: PMC321452.
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PubMed Mentions:
71 Fields:
Translation:
AnimalsCells
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High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell. 2004 Jan 30; 13(2):225-39.
Krogan NJ, Peng WT, Cagney G, Robinson MD, Haw R, Zhong G, Guo X, Zhang X, Canadien V, Richards DP, Beattie BK, Lalev A, Zhang W, Davierwala AP, Mnaimneh S, Starostine A, Tikuisis AP, Grigull J, Datta N, Bray JE, Hughes TR, Emili A, Greenblatt JF. PMID: 14759368.
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PubMed Mentions:
216 Fields:
Translation:
AnimalsCells
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Transitions in RNA polymerase II elongation complexes at the 3' ends of genes. EMBO J. 2004 Jan 28; 23(2):354-64.
Kim M, Ahn SH, Krogan NJ, Greenblatt JF, Buratowski S. PMID: 14739930; PMCID: PMC1271760.
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PubMed Mentions:
177 Fields:
Translation:
Cells
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A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell. 2003 Dec; 12(6):1565-76.
Krogan NJ, Keogh MC, Datta N, Sawa C, Ryan OW, Ding H, Haw RA, Pootoolal J, Tong A, Canadien V, Richards DP, Wu X, Emili A, Hughes TR, Buratowski S, Greenblatt JF. PMID: 14690608.
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PubMed Mentions:
286 Fields:
Translation:
HumansAnimalsCells
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A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science. 2003 Oct 17; 302(5644):449-53.
Jansen R, Yu H, Greenbaum D, Kluger Y, Krogan NJ, Chung S, Emili A, Snyder M, Greenblatt JF, Gerstein M. PMID: 14564010.
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PubMed Mentions:
416 Fields:
Translation:
AnimalsCells
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A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33.
Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. PMID: 12837249.
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PubMed Mentions:
124 Fields:
Translation:
AnimalsCells
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Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol. 2003 Jun; 23(12):4207-18.
Krogan NJ, Kim M, Tong A, Golshani A, Cagney G, Canadien V, Richards DP, Beattie BK, Emili A, Boone C, Shilatifard A, Buratowski S, Greenblatt J. PMID: 12773564; PMCID: PMC427527.
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PubMed Mentions:
340 Fields:
Translation:
AnimalsCells
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The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell. 2003 Mar; 11(3):721-9.
Krogan NJ, Dover J, Wood A, Schneider J, Heidt J, Boateng MA, Dean K, Ryan OW, Golshani A, Johnston M, Greenblatt JF, Shilatifard A. PMID: 12667454.
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PubMed Mentions:
363 Fields:
Translation:
AnimalsCells
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Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell. 2003 Jan; 11(1):267-74.
Wood A, Krogan NJ, Dover J, Schneider J, Heidt J, Boateng MA, Dean K, Golshani A, Zhang Y, Greenblatt JF, Johnston M, Shilatifard A. PMID: 12535539.
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PubMed Mentions:
259 Fields:
Translation:
AnimalsCells
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RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol. 2002 Oct; 22(20):6979-92.
Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, Emili A, Shilatifard A, Buratowski S, Greenblatt JF. PMID: 12242279; PMCID: PMC139818.
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PubMed Mentions:
271 Fields:
Translation:
AnimalsCells
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COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem. 2002 Mar 29; 277(13):10753-5.
Krogan NJ, Dover J, Khorrami S, Greenblatt JF, Schneider J, Johnston M, Shilatifard A. PMID: 11805083.
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PubMed Mentions:
209 Fields:
Translation:
AnimalsCells
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Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae. Mol Cell Biol. 2001 Dec; 21(23):8203-12.
Krogan NJ, Greenblatt JF. PMID: 11689709; PMCID: PMC99985.
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PubMed Mentions:
83 Fields:
Translation:
AnimalsCells
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COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):12902-7.
Miller T, Krogan NJ, Dover J, Erdjument-Bromage H, Tempst P, Johnston M, Greenblatt JF, Shilatifard A. PMID: 11687631; PMCID: PMC60797.
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PubMed Mentions:
287 Fields:
Translation:
Cells
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A combination of three mutations, dcd, pyrH, and cdd, establishes thymidine (Deoxyuridine) auxotrophy in thyA+ strains of Salmonella typhimurium. J Bacteriol. 1998 Nov; 180(22):5891-5.
Krogan NJ, Zaharik ML, Neuhard J, Kelln RA. PMID: 9811646; PMCID: PMC107662.
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PubMed Mentions:
2 Fields:
Translation:
Cells