Nicholas Polizzi, PhD

Title(s)Postdoctoral Scholar, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Cornell University, Ithaca, NYBS12/2007Biology
    Duke University, Durham, NCPhD06/2016Biochemistry

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    De novo design of small-molecule-binding proteins
    NIH K99GM135519Jul 15, 2020 - Jun 30, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ. Elife. 2021 12 14; 10. Mensa B, Polizzi NF, Molnar KS, Natale AM, Lemmin T, DeGrado WF. PMID: 34904568; PMCID: PMC8719878.
      View in: PubMed   Mentions:
    2. Allosteric cooperation in a de novo-designed two-domain protein. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33246-33253. Pirro F, Schmidt N, Lincoff J, Widel ZX, Polizzi NF, Liu L, Therien MJ, Grabe M, Chino M, Lombardi A, DeGrado WF. PMID: 33318174; PMCID: PMC7776816.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    3. A defined structural unit enables de novo design of small-molecule-binding proteins. Science. 2020 09 04; 369(6508):1227-1233. Polizzi NF, DeGrado WF. PMID: 32883865; PMCID: PMC7526616.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    4. Excitation energy-dependent photocurrent switching in a single-molecule photodiode. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16198-16203. Shan B, Nayak A, Williams OF, Yost DC, Polizzi NF, Liu Y, Zhou N, Kanai Y, Moran AM, Therien MJ, Meyer TJ. PMID: 31366631; PMCID: PMC6697812.
      View in: PubMed   Mentions: 1     Fields:    
    5. Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts. Biochemistry. 2019 07 30; 58(30):3251-3259. Tan SK, Fong KP, Polizzi NF, Sternisha A, Slusky JSG, Yoon K, DeGrado WF, Bennett JS. PMID: 31264850; PMCID: PMC7405930.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case. J Am Chem Soc. 2019 07 24; 141(29):11481-11488. Thomaston JL, Wu Y, Polizzi N, Liu L, Wang J, DeGrado WF. PMID: 31184871; PMCID: PMC7405929.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    7. Engineering opposite electronic polarization of singlet and triplet states increases the yield of high-energy photoproducts. Proc Natl Acad Sci U S A. 2019 07 16; 116(29):14465-14470. Polizzi NF, Jiang T, Beratan DN, Therien MJ. PMID: 31182609; PMCID: PMC6642396.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    8. Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins. J Am Chem Soc. 2019 05 15; 141(19):7698-7703. Yang B, Wang N, Schnier PD, Zheng F, Zhu H, Polizzi NF, Ittuveetil A, Saikam V, DeGrado WF, Wang Q, Wang PG, Wang L. PMID: 31038942; PMCID: PMC6556376.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    9. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032; PMCID: PMC6286348.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    10. Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J Am Chem Soc. 2018 11 14; 140(45):15219-15226. Thomaston JL, Polizzi NF, Konstantinidi A, Wang J, Kolocouris A, DeGrado WF. PMID: 30165017; PMCID: PMC6497056.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    11. Molecular Road Map to Tuning Ground State Absorption and Excited State Dynamics of Long-Wavelength Absorbers. J Am Chem Soc. 2017 11 22; 139(46):16946-16958. Bai Y, Olivier JH, Yoo H, Polizzi NF, Park J, Rawson J, Therien MJ. PMID: 29043788.
      View in: PubMed   Mentions: 4     Fields:    
    12. De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. Nat Chem. 2017 12; 9(12):1157-1164. Polizzi NF, Wu Y, Lemmin T, Maxwell AM, Zhang SQ, Rawson J, Beratan DN, Therien MJ, DeGrado WF. PMID: 29168496; PMCID: PMC5859929.
      View in: PubMed   Mentions: 22     Fields:    
    13. Engineering High-Potential Photo-oxidants with Panchromatic Absorption. J Am Chem Soc. 2017 06 28; 139(25):8412-8415. Jiang T, Polizzi NF, Rawson J, Therien MJ. PMID: 28613070.
      View in: PubMed   Mentions: 3     Fields:    
    14. Zinc-binding structure of a catalytic amyloid from solid-state NMR. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6191-6196. Lee M, Wang T, Makhlynets OV, Wu Y, Polizzi NF, Wu H, Gosavi PM, Stöhr J, Korendovych IV, DeGrado WF, Hong M. PMID: 28566494; PMCID: PMC5474797.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    15. Mean First-Passage Times in Biology. Isr J Chem. 2016 Nov; 56(9-10):816-824. Polizzi NF, Therien MJ, Beratan DN. PMID: 29081538; PMCID: PMC5656268.
      View in: PubMed   Mentions: 4  
    16. Where Is the Electronic Oscillator Strength? Mapping Oscillator Strength across Molecular Absorption Spectra. J Phys Chem A. 2016 Mar 24; 120(11):1933-43. Zheng L, Polizzi NF, Dave AR, Migliore A, Beratan DN. PMID: 26950828; PMCID: PMC4849861.
      View in: PubMed   Mentions: 3     Fields:    
    17. Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein. J Am Chem Soc. 2016 Feb 24; 138(7):2130-3. Polizzi NF, Eibling MJ, Perez-Aguilar JM, Rawson J, Lanci CJ, Fry HC, Beratan DN, Saven JG, Therien MJ. PMID: 26840013; PMCID: PMC5049705.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    18. Open-Access, Interactive Explorations for Teaching and Learning Quantum Dynamics. Journal of Chemical Education. 2015 Dec 8; 92(12):2161-2164. Polizzi PN, Beratan BD. .
      View in: Publisher Site   Mentions:
    19. Defusing redox bombs? Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10821-2. Polizzi NF, Migliore A, Therien MJ, Beratan DN. PMID: 26290579; PMCID: PMC4568230.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    20. Charge transfer in dynamical biosystems, or the treachery of (static) images. Acc Chem Res. 2015 Feb 17; 48(2):474-81. Beratan DN, Liu C, Migliore A, Polizzi NF, Skourtis SS, Zhang P, Zhang Y. PMID: 25307316; PMCID: PMC4333612.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    21. Biochemistry and theory of proton-coupled electron transfer. Chem Rev. 2014 Apr 09; 114(7):3381-465. Migliore A, Polizzi NF, Therien MJ, Beratan DN. PMID: 24684625; PMCID: PMC4317057.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    22. Physical constraints on charge transport through bacterial nanowires. Faraday Discuss. 2012; 155:43-62; discussion 103-14. Polizzi NF, Skourtis SS, Beratan DN. PMID: 22470966; PMCID: PMC3392031.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
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