Nicholas Polizzi • UCSF Profiles

Nicholas Polizzi, PhD

Title(s)	Postdoctoral Scholar, Pharmaceutical Chemistry
School	School of Pharmacy
Address	555 Mission Bay Blvd South San Francisco CA 94158
Phone	--
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Biography

Education and Training

Cornell University, Ithaca, NY	BS	12/2007	Biology
Duke University, Durham, NC	PhD	06/2016	Biochemistry

Overview

Interests

Protein design, Ligand binding, Biological energy transduction, Light-driven reactions, Protein structure/function relationships

Research

Research Activities and Funding

De novo design of small-molecule-binding proteins
NIH K99GM135519Jul 15, 2020 - Jun 30, 2022
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ. Elife. 2021 12 14; 10. Mensa B, Polizzi NF, Molnar KS, Natale AM, Lemmin T, DeGrado WF. PMID: 34904568; PMCID: PMC8719878.

View in: PubMed Mentions:
Allosteric cooperation in a de novo-designed two-domain protein. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33246-33253. Pirro F, Schmidt N, Lincoff J, Widel ZX, Polizzi NF, Liu L, Therien MJ, Grabe M, Chino M, Lombardi A, DeGrado WF. PMID: 33318174.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Cells
A defined structural unit enables de novo design of small-molecule-binding proteins. Science. 2020 09 04; 369(6508):1227-1233. Polizzi NF, DeGrado WF. PMID: 32883865.

View in: PubMed Mentions: 7 Fields:
Sci Science
Translation:Cells
Excitation energy-dependent photocurrent switching in a single-molecule photodiode. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16198-16203. Shan B, Nayak A, Williams OF, Yost DC, Polizzi NF, Liu Y, Zhou N, Kanai Y, Moran AM, Therien MJ, Meyer TJ. PMID: 31366631.

View in: PubMed Mentions: 1 Fields:
Sci Science
Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts. Biochemistry. 2019 07 30; 58(30):3251-3259. Tan SK, Fong KP, Polizzi NF, Sternisha A, Slusky JSG, Yoon K, DeGrado WF, Bennett JS. PMID: 31264850.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case. J Am Chem Soc. 2019 07 24; 141(29):11481-11488. Thomaston JL, Wu Y, Polizzi N, Liu L, Wang J, DeGrado WF. PMID: 31184871.

View in: PubMed Mentions: 6 Fields:
Che Chemistry
Translation:Cells
Engineering opposite electronic polarization of singlet and triplet states increases the yield of high-energy photoproducts. Proc Natl Acad Sci U S A. 2019 07 16; 116(29):14465-14470. Polizzi NF, Jiang T, Beratan DN, Therien MJ. PMID: 31182609.

View in: PubMed Mentions: 3 Fields:
Sci Science
Translation:Cells
Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins. J Am Chem Soc. 2019 05 15; 141(19):7698-7703. Yang B, Wang N, Schnier PD, Zheng F, Zhu H, Polizzi NF, Ittuveetil A, Saikam V, DeGrado WF, Wang Q, Wang PG, Wang L. PMID: 31038942.

View in: PubMed Mentions: 14 Fields:
Che Chemistry
Translation:Cells
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032.

View in: PubMed Mentions: 14 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J Am Chem Soc. 2018 11 14; 140(45):15219-15226. Thomaston JL, Polizzi NF, Konstantinidi A, Wang J, Kolocouris A, DeGrado WF. PMID: 30165017.

View in: PubMed Mentions: 16 Fields:
Che Chemistry
Translation:Cells
Molecular Road Map to Tuning Ground State Absorption and Excited State Dynamics of Long-Wavelength Absorbers. J Am Chem Soc. 2017 11 22; 139(46):16946-16958. Bai Y, Olivier JH, Yoo H, Polizzi NF, Park J, Rawson J, Therien MJ. PMID: 29043788.

View in: PubMed Mentions: 4 Fields:
Che Chemistry
De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. Nat Chem. 2017 12; 9(12):1157-1164. Polizzi NF, Wu Y, Lemmin T, Maxwell AM, Zhang SQ, Rawson J, Beratan DN, Therien MJ, DeGrado WF. PMID: 29168496; PMCID: PMC5859929.

View in: PubMed Mentions: 22 Fields:
Che Chemistry
Engineering High-Potential Photo-oxidants with Panchromatic Absorption. J Am Chem Soc. 2017 06 28; 139(25):8412-8415. Jiang T, Polizzi NF, Rawson J, Therien MJ. PMID: 28613070.

View in: PubMed Mentions: 3 Fields:
Che Chemistry
Zinc-binding structure of a catalytic amyloid from solid-state NMR. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6191-6196. Lee M, Wang T, Makhlynets OV, Wu Y, Polizzi NF, Wu H, Gosavi PM, Stöhr J, Korendovych IV, DeGrado WF, Hong M. PMID: 28566494; PMCID: PMC5474797.

View in: PubMed Mentions: 25 Fields:
Sci Science
Translation:Cells
Mean First-Passage Times in Biology. Isr J Chem. 2016 Nov; 56(9-10):816-824. Polizzi NF, Therien MJ, Beratan DN. PMID: 29081538.

View in: PubMed Mentions: 4
Where Is the Electronic Oscillator Strength? Mapping Oscillator Strength across Molecular Absorption Spectra. J Phys Chem A. 2016 Mar 24; 120(11):1933-43. Zheng L, Polizzi NF, Dave AR, Migliore A, Beratan DN, Zheng L, Polizzi NF, Dave AR, Migliore A, Beratan DN. PMID: 26950828; PMCID: PMC4849861.

View in: PubMed Mentions: 3 Fields:
Che Chemistry
Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein. J Am Chem Soc. 2016 Feb 24; 138(7):2130-3. Polizzi NF, Eibling MJ, Perez-Aguilar JM, Rawson J, Lanci CJ, Fry HC, Beratan DN, Saven JG, Therien MJ, Polizzi NF, Eibling MJ, Perez-Aguilar JM, Rawson J, Lanci CJ, Fry HC, Beratan DN, Saven JG, Therien MJ. PMID: 26840013; PMCID: PMC5049705.

View in: PubMed Mentions: 3 Fields:
Che Chemistry
Translation:Cells
Open-Access, Interactive Explorations for Teaching and Learning Quantum Dynamics. Journal of Chemical Education. 2015 Dec 8; 92(12):2161-2164. Polizzi PN, Beratan BD. .

View in: Publisher Site Mentions:
Defusing redox bombs? Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10821-2. Polizzi NF, Migliore A, Therien MJ, Beratan DN, Polizzi NF, Migliore A, Therien MJ, Beratan DN. PMID: 26290579; PMCID: PMC4568230.

View in: PubMed Mentions: 10 Fields:
Sci Science
Translation:Humans
Charge transfer in dynamical biosystems, or the treachery of (static) images. Acc Chem Res. 2015 Feb 17; 48(2):474-81. Beratan DN, Liu C, Migliore A, Polizzi NF, Skourtis SS, Zhang P, Zhang Y, Beratan DN, Liu C, Migliore A, Polizzi NF, Skourtis SS, Zhang P, Zhang Y. PMID: 25307316; PMCID: PMC4333612.

View in: PubMed Mentions: 30 Fields:
Che Chemistry
Translation:Cells
Biochemistry and theory of proton-coupled electron transfer. Chem Rev. 2014 Apr 09; 114(7):3381-465. Migliore A, Polizzi NF, Therien MJ, Beratan DN, Migliore A, Polizzi NF, Therien MJ, Beratan DN. PMID: 24684625; PMCID: PMC4317057.

View in: PubMed Mentions: 65 Fields:
Che Chemistry
Translation:Cells
Physical constraints on charge transport through bacterial nanowires. Faraday Discuss. 2012; 155:43-62; discussion 103-14. Polizzi NF, Skourtis SS, Beratan DN, Polizzi NF, Skourtis SS, Beratan DN. PMID: 22470966; PMCID: PMC3392031.

View in: PubMed Mentions: 37 Fields:
Che Chemistry
Translation:Cells