Nicholas Polizzi • UCSF Profiles

Nicholas Polizzi, PhD

Title(s)	Postdoctoral Scholar, Pharmaceutical Chemistry
School	School of Pharmacy
Address	555 Mission Bay Blvd South San Francisco CA 94158
Phone	--
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Biography

Education and Training

Cornell University, Ithaca, NY	BS	12/2007	Biology
Duke University, Durham, NC	PhD	06/2016	Biochemistry

Overview

Interests

Protein design, Ligand binding, Biological energy transduction, Light-driven reactions, Protein structure/function relationships

Research

Research Activities and Funding

De novo design of small-molecule-binding proteins
NIH K99GM135519Jul 15, 2020 - Jun 30, 2022
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Allosteric cooperation in a de novo-designed two-domain protein. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33246-33253. Pirro F, Schmidt N, Lincoff J, Widel ZX, Polizzi NF, Liu L, Therien MJ, Grabe M, Chino M, Lombardi A, DeGrado WF. PMID: 33318174.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Cells
A defined structural unit enables de novo design of small-molecule-binding proteins. Science. 2020 09 04; 369(6508):1227-1233. Polizzi NF, DeGrado WF. PMID: 32883865.

View in: PubMed Mentions: 7 Fields:
Sci Science
Translation:Cells
Excitation energy-dependent photocurrent switching in a single-molecule photodiode. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16198-16203. Shan B, Nayak A, Williams OF, Yost DC, Polizzi NF, Liu Y, Zhou N, Kanai Y, Moran AM, Therien MJ, Meyer TJ. PMID: 31366631.

View in: PubMed Mentions: 1 Fields:
Sci Science
Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts. Biochemistry. 2019 07 30; 58(30):3251-3259. Tan SK, Fong KP, Polizzi NF, Sternisha A, Slusky JSG, Yoon K, DeGrado WF, Bennett JS. PMID: 31264850.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case. J Am Chem Soc. 2019 07 24; 141(29):11481-11488. Thomaston JL, Wu Y, Polizzi N, Liu L, Wang J, DeGrado WF. PMID: 31184871.

View in: PubMed Mentions: 6 Fields:
Che Chemistry
Translation:Cells
Engineering opposite electronic polarization of singlet and triplet states increases the yield of high-energy photoproducts. Proc Natl Acad Sci U S A. 2019 07 16; 116(29):14465-14470. Polizzi NF, Jiang T, Beratan DN, Therien MJ. PMID: 31182609.

View in: PubMed Mentions: 3 Fields:
Sci Science
Translation:Cells
Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins. J Am Chem Soc. 2019 05 15; 141(19):7698-7703. Yang B, Wang N, Schnier PD, Zheng F, Zhu H, Polizzi NF, Ittuveetil A, Saikam V, DeGrado WF, Wang Q, Wang PG, Wang L. PMID: 31038942.

View in: PubMed Mentions: 14 Fields:
Che Chemistry
Translation:Cells
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032.

View in: PubMed Mentions: 14 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J Am Chem Soc. 2018 11 14; 140(45):15219-15226. Thomaston JL, Polizzi NF, Konstantinidi A, Wang J, Kolocouris A, DeGrado WF. PMID: 30165017.

View in: PubMed Mentions: 16 Fields:
Che Chemistry
Translation:Cells
Molecular Road Map to Tuning Ground State Absorption and Excited State Dynamics of Long-Wavelength Absorbers. J Am Chem Soc. 2017 11 22; 139(46):16946-16958. Bai Y, Olivier JH, Yoo H, Polizzi NF, Park J, Rawson J, Therien MJ. PMID: 29043788.

View in: PubMed Mentions: 4 Fields:
Che Chemistry
De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. Nat Chem. 2017 12; 9(12):1157-1164. Polizzi NF, Wu Y, Lemmin T, Maxwell AM, Zhang SQ, Rawson J, Beratan DN, Therien MJ, DeGrado WF. PMID: 29168496.

View in: PubMed Mentions: 22 Fields:
Che Chemistry
Engineering High-Potential Photo-oxidants with Panchromatic Absorption. J Am Chem Soc. 2017 06 28; 139(25):8412-8415. Jiang T, Polizzi NF, Rawson J, Therien MJ. PMID: 28613070.

View in: PubMed Mentions: 3 Fields:
Che Chemistry
Zinc-binding structure of a catalytic amyloid from solid-state NMR. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6191-6196. Lee M, Wang T, Makhlynets OV, Wu Y, Polizzi NF, Wu H, Gosavi PM, Stöhr J, Korendovych IV, DeGrado WF, Hong M. PMID: 28566494.

View in: PubMed Mentions: 24 Fields:
Sci Science
Translation:Cells
Mean First-Passage Times in Biology. Isr J Chem. 2016 Nov; 56(9-10):816-824. Polizzi NF, Therien MJ, Beratan DN. PMID: 29081538.

View in: PubMed Mentions:
Where Is the Electronic Oscillator Strength? Mapping Oscillator Strength across Molecular Absorption Spectra. J Phys Chem A. 2016 Mar 24; 120(11):1933-43. Zheng L, Polizzi NF, Dave AR, Migliore A, Beratan DN. PMID: 26950828.

View in: PubMed Mentions: 3 Fields:
Che Chemistry
Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein. J Am Chem Soc. 2016 Feb 24; 138(7):2130-3. Polizzi NF, Eibling MJ, Perez-Aguilar JM, Rawson J, Lanci CJ, Fry HC, Beratan DN, Saven JG, Therien MJ. PMID: 26840013.

View in: PubMed Mentions: 3 Fields:
Che Chemistry
Translation:Cells
Open-Access, Interactive Explorations for Teaching and Learning Quantum Dynamics. Journal of Chemical Education. 2015 Dec 8; 92(12):2161-2164. Nicholas F. Polizzi, David N. Beratan. .

View in: Publisher Site Mentions:
Defusing redox bombs? Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10821-2. Polizzi NF, Migliore A, Therien MJ, Beratan DN. PMID: 26290579.

View in: PubMed Mentions: 10 Fields:
Sci Science
Translation:Humans
Charge transfer in dynamical biosystems, or the treachery of (static) images. Acc Chem Res. 2015 Feb 17; 48(2):474-81. Beratan DN, Liu C, Migliore A, Polizzi NF, Skourtis SS, Zhang P, Zhang Y. PMID: 25307316.

View in: PubMed Mentions: 30 Fields:
Che Chemistry
Translation:Cells
Biochemistry and theory of proton-coupled electron transfer. Chem Rev. 2014 Apr 09; 114(7):3381-465. Migliore A, Polizzi NF, Therien MJ, Beratan DN. PMID: 24684625.

View in: PubMed Mentions: 65 Fields:
Che Chemistry
Translation:Cells
Physical constraints on charge transport through bacterial nanowires. Faraday Discuss. 2012; 155:43-62; discussion 103-14. Polizzi NF, Skourtis SS, Beratan DN. PMID: 22470966.

View in: PubMed Mentions: 37 Fields:
Che Chemistry
Translation:Cells