Nicole Paulk, PhD
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Title(s) | Assistant Professor, Biochemistry and Biophysics |
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School | School of Medicine |
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Address | 1700 4th St San Francisco CA 94158
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Phone | -- |
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ORCID
.gif) | 0000-0002-5557-6280  |
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vCard | Download vCard |
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Biography Stanford University | Postdoc | 08/2016 | Human Gene Therapy | Oregon Health & Science University | PhD | 06/2012 | Viral Gene Therapy | Central Washington University | BS | 06/2006 | Medical Microbiology |
Overview For patients seeking treatment for rare genetic diseases and cancer, the standard of care can often be invasive (e.g. organ transplantation or surgical debulking) and temporary (e.g. enzyme replacement therapy or chemotherapy). AAV gene therapies are attractive alternatives as they are non-invasive with long-term therapeutic benefits. However, the success of this new generation of transformative therapies is critically dependent on successful delivery, strong efficacy, improved safety and reduced cost. In the Paulk lab we engineer disruptive technologies to directly address each of these to make AAV cheaper, easier and faster to get these life-saving drugs to the patients who need them.
AAV, Gene Therapy, Bioengineering, Cancer, Rare Disease, Immunotherapy, Technology Development, Proteomics, Genomics, Epigenomics, Sexual Dimorphism
Research ORNG Applications Bibliographic
Altmetrics Details
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(Note that publications are often cited in additional ways that are not shown here.)
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Methods Matter -- Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors. Molecular Therapy - Methods & Clinical Development. 2020 Sep 1; 18:98-118.
Neil G. Rumachik, Stacy A. Malaker, Nicole Poweleit, Lucy H. Maynard, Christopher M. Adams, Ryan D. Leib, Giana Cirolia, Dennis Thomas, Susan Stamnes, Kathleen Holt, Patrick Sinn, Andrew P. May, Nicole K. Paulk. .
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Gene Therapy: It Is Time to Talk about High-Dose AAV. Genetic Engineering & Biotechnology News. 2020 Sep 1; 40(9):14-16.
Nicole Paulk. .
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Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors. Mol Ther Methods Clin Dev. 2020 Sep 11; 18:98-118.
Rumachik NG, Malaker SA, Poweleit N, Maynard LH, Adams CM, Leib RD, Cirolia G, Thomas D, Stamnes S, Holt K, Sinn P, May AP, Paulk NK. PMID: 32995354.
View in: PubMed Mentions:
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Fast-Seq: A Simple Method for Rapid and Inexpensive Validation of Packaged Single-Stranded Adeno-Associated Viral Genomes in Academic Settings. Hum Gene Ther Methods. 2019 12; 30(6):195-205.
Maynard LH, Smith O, Tilmans NP, Tham E, Hosseinzadeh S, Tan W, Leenay R, May AP, Paulk NK. PMID: 31855083.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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An orange calcium-modulated bioluminescent indicator for non-invasive activity imaging. Nat Chem Biol. 2019 05; 15(5):433-436.
Oh Y, Park Y, Cho JH, Wu H, Paulk NK, Liu LX, Kim N, Kay MA, Wu JC, Lin MZ. PMID: 30936501.
View in: PubMed Mentions: 3 Fields: Translation: Animals
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Bioengineered Viral Platform for Intramuscular Passive Vaccine Delivery to Human Skeletal Muscle. Mol Ther Methods Clin Dev. 2018 Sep 21; 10:144-155.
Paulk NK, Pekrun K, Charville GW, Maguire-Nguyen K, Wosczyna MN, Xu J, Zhang Y, Lisowski L, Yoo B, Vilches-Moure JG, Lee GK, Shrager JB, Rando TA, Kay MA. PMID: 30101152.
View in: PubMed Mentions:
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Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity. Nat Commun. 2017 12 12; 8(1):2053.
Winters IP, Chiou SH, Paulk NK, McFarland CD, Lalgudi PV, Ma RK, Lisowski L, Connolly AJ, Petrov DA, Kay MA, Winslow MM. PMID: 29233960.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Rescue of Pompe disease in mice by AAV-mediated liver delivery of secretable acid a-glucosidase. Sci Transl Med. 2017 Nov 29; 9(418).
Puzzo F, Colella P, Biferi MG, Bali D, Paulk NK, Vidal P, Collaud F, Simon-Sola M, Charles S, Hardet R, Leborgne C, Meliani A, Cohen-Tannoudji M, Astord S, Gjata B, Sellier P, van Wittenberghe L, Vignaud A, Boisgerault F, Barkats M, Laforet P, Kay MA, Koeberl DD, Ronzitti G, Mingozzi F. PMID: 29187643.
View in: PubMed Mentions: 30 Fields: Translation: AnimalsCells
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Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity. Mol Ther. 2018 01 03; 26(1):289-303.
Paulk NK, Pekrun K, Zhu E, Nygaard S, Li B, Xu J, Chu K, Leborgne C, Dane AP, Haft A, Zhang Y, Zhang F, Morton C, Valentine MB, Davidoff AM, Nathwani AC, Mingozzi F, Grompe M, Alexander IE, Lisowski L, Kay MA. PMID: 29055620.
View in: PubMed Mentions: 34 Fields: Translation: HumansAnimalsCells
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Promoterless gene targeting without nucleases ameliorates haemophilia B in mice. Nature. 2015 Jan 15; 517(7534):360-4.
PMID: 25363772.
View in: PubMed Mentions: 80 Fields: Translation: HumansAnimalsCells
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In vivo selection of transplanted hepatocytes by pharmacological inhibition of fumarylacetoacetate hydrolase in wild-type mice. Mol Ther. 2012 Oct; 20(10):1981-7.
PMID: 22871666.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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AAV-mediated gene targeting is significantly enhanced by transient inhibition of nonhomologous end joining or the proteasome in vivo. Hum Gene Ther. 2012 Jun; 23(6):658-65.
PMID: 22486314.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition. Osteoarthritis Cartilage. 2012 Aug; 20(8):880-6.
PMID: 22542924.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Novel strategies to improve viral gene targeting and therapeutic liver repopulation in vivo. 2012.
Paulk NK. . View Publication.
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Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo. Hepatology. 2010 Apr; 51(4):1200-8.
Paulk NK, Wursthorn K, Wang Z, Finegold MJ, Kay MA, Grompe M. PMID: 20162619.
View in: PubMed Mentions: 40 Fields: Translation: AnimalsCells
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Ploidy reductions in murine fusion-derived hepatocytes. PLoS Genet. 2009 Feb; 5(2):e1000385.
Duncan AW, Hickey RD, Paulk NK, Culberson AJ, Olson SB, Finegold MJ, Grompe M. PMID: 19229314.
View in: PubMed Mentions: 36 Fields: Translation: AnimalsCells
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Effects of DMSO oxidation products on iron speciation in photochemical simulation experiments. Environ Sci Technol. 2008; 1(42):133-139.
Key J, Paulk N, and Johansen A. View Publication.
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Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nat Biotechnol. 2007 Aug; 25(8):903-10.
Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, Strom S, Kay MA, Finegold M, Grompe M. PMID: 17664939.
View in: PubMed Mentions: 246 Fields: Translation: HumansAnimalsCells
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Year | Publications |
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2007 | 1 | 2008 | 1 | 2009 | 1 | 2010 | 1 | 2012 | 4 | 2014 | 1 | 2017 | 3 | 2018 | 1 | 2019 | 2 | 2020 | 2 |
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This graph shows the number and percent of publications by field.
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