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Noah Zaitlen, PhD

Title(s)Assistant Professor in Res, Medicine
SchoolSchool of Medicine
Phone415-502-2027
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    Collapse Research 
    Collapse Research Activities and Funding
    Improved methods for inference of genotype-specific response to environmental toxins
    NIH/NIEHS R01ES029929Feb 1, 2019 - Jan 31, 2024
    Role: Co-Principal Investigator
    Epigenetics of Socio-Environmental Effects on Asthma in Minorities
    NIH/NIMHD R56MD013312Sep 25, 2018 - Sep 24, 2019
    Role: Principal Investigator
    (PQ3) A functional genomic approach to identification and interpretation of germline-tumor genetic interactions
    NIH/NCI R01CA227237Jun 8, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Leveraging Novel Multivariate Methods of Subphenotypes in Genetic Association Studies of Sjogren?s Syndrome
    NIH/NIDCR R03DE025665Sep 2, 2016 - Aug 31, 2018
    Role: Co-Principal Investigator
    Richer Models of Asthma Risk: Bridging the Environment-Genetics Divide
    NIH/NHLBI K25HL121295Aug 1, 2014 - Oct 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gallois A, Mefford J, Ko A, Vaysse A, Julienne H, Ala-Korpela M, Laakso M, Zaitlen N, Pajukanta P, Aschard H. A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context. Nat Commun. 2019 Oct 21; 10(1):4788. PMID: 31636271.
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    2. Hernandez RD, Uricchio LH, Hartman K, Ye C, Dahl A, Zaitlen N. Ultrarare variants drive substantial cis heritability of human gene expression. Nat Genet. 2019 Sep; 51(9):1349-1355. PMID: 31477931.
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    3. Dahl A, Cai N, Ko A, Laakso M, Pajukanta P, Flint J, Zaitlen N. Reverse GWAS: Using genetics to identify and model phenotypic subtypes. PLoS Genet. 2019 04; 15(4):e1008009. PMID: 30951530.
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    4. Aschard H, Laville V, Tchetgen ET, Knights D, Imhann F, Seksik P, Zaitlen N, Silverberg MS, Cosnes J, Weersma RK, Xavier R, Beaugerie L, Skurnik D, Sokol H. Genetic effects on the commensal microbiota in inflammatory bowel disease patients. PLoS Genet. 2019 03; 15(3):e1008018. PMID: 30849075.
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    5. Lea A, Subramaniam M, Ko A, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Mononen N, Raitakari OT, Ala-Korpela M, Pajukanta P, Zaitlen N, Ayroles JF. Genetic and environmental perturbations lead to regulatory decoherence. Elife. 2019 Mar 05; 8. PMID: 30834892.
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    6. Boettcher M, Covarrubias S, Biton A, Blau J, Wang H, Zaitlen N, McManus MT. Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding. BMC Genomics. 2019 Feb 06; 20(1):107. PMID: 30727954.
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    7. Dahl A, Guillemot V, Mefford J, Aschard H, Zaitlen N. Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives. Genetics. 2019 04; 211(4):1179-1189. PMID: 30692194.
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    8. Uricchio LH, Kitano HC, Gusev A, Zaitlen NA. An evolutionary compass for detecting signals of polygenic selection and mutational bias. Evol Lett. 2019 Feb; 3(1):69-79. PMID: 30788143.
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    9. Galinsky KJ, Reshef YA, Finucane HK, Loh PR, Zaitlen N, Patterson NJ, Brown BC, Price AL. Estimating cross-population genetic correlations of causal effect sizes. Genet Epidemiol. 2019 03; 43(2):180-188. PMID: 30474154.
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    10. Conlon EG, Fagegaltier D, Agius P, Davis-Porada J, Gregory J, Hubbard I, Kang K, Kim D, Phatnani H, Kwan J, Sareen D, Broach JR, Simmons Z, Arcila-Londono X, Lee EB, Van Deerlin VM, Shneider NA, Fraenkel E, Ostrow LW, Baas F, Zaitlen N, Berry JD, Malaspina A, Fratta P, Cox GA, Thompson LM, Finkbeiner S, Dardiotis E, Miller TM, Chandran S, Pal S, Hornstein E, MacGowan DJ, Heiman-Patterson T, Hammell MG, Patsopoulos NA, Dubnau J, Nath A, Phatnani H, Shneider NA, Manley JL. Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism. Elife. 2018 07 13; 7. PMID: 30003873.
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    11. Mak ACY, White MJ, Eckalbar WL, Szpiech ZA, Oh SS, Pino-Yanes M, Hu D, Goddard P, Huntsman S, Galanter J, Wu AC, Himes BE, Germer S, Vogel JM, Bunting KL, Eng C, Salazar S, Keys KL, Liberto J, Nuckton TJ, Nguyen TA, Torgerson DG, Kwok PY, Levin AM, Celedón JC, Forno E, Hakonarson H, Sleiman PM, Dahlin A, Tantisira KG, Weiss ST, Serebrisky D, Brigino-Buenaventura E, Farber HJ, Meade K, Lenoir MA, Avila PC, Sen S, Thyne SM, Rodriguez-Cintron W, Winkler CA, Moreno-Estrada A, Sandoval K, Rodriguez-Santana JR, Kumar R, Williams LK, Ahituv N, Ziv E, Seibold MA, Darnell RB, Zaitlen N, Hernandez RD, Burchard EG. Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma. Am J Respir Crit Care Med. 2018 06 15; 197(12):1552-1564. PMID: 29509491.
      View in: PubMed
    12. Kang EY, Lee CH, Furlotte NA, Joo JWJ, Kostem E, Zaitlen N, Eskin E, Han B. An Association Mapping Framework To Account for Potential Sex Difference in Genetic Architectures. Genetics. 2018 07; 209(3):685-698. PMID: 29752291.
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    13. Peterson RE, Cai N, Dahl AW, Bigdeli TB, Edwards AC, Webb BT, Bacanu SA, Zaitlen N, Flint J, Kendler KS. Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression. Am J Psychiatry. 2018 06 01; 175(6):545-554. PMID: 29495898.
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    14. Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY, Woodruff PG, Burchard E, Seibold MA, Shifman S, Eskin E, Zaitlen N. ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues. Genome Biol. 2018 02 15; 19(1):36. PMID: 29548336.
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    15. Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT. Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nat Biotechnol. 2018 02; 36(2):170-178. PMID: 29334369.
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    16. Kang HM, Subramaniam M, Targ S, Nguyen M, Maliskova L, McCarthy E, Wan E, Wong S, Byrnes L, Lanata CM, Gate RE, Mostafavi S, Marson A, Zaitlen N, Criswell LA, Ye CJ. Multiplexed droplet single-cell RNA-sequencing using natural genetic variation. Nat Biotechnol. 2018 01; 36(1):89-94. PMID: 29227470.
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    17. Park DS, Eskin I, Kang EY, Gamazon ER, Eng C, Gignoux CR, Galanter JM, Burchard E, Ye CJ, Aschard H, Eskin E, Halperin E, Zaitlen N. An ancestry-based approach for detecting interactions. Genet Epidemiol. 2018 02; 42(1):49-63. PMID: 29114909.
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    18. Aschard H, Guillemot V, Vilhjalmsson B, Patel CJ, Skurnik D, Ye CJ, Wolpin B, Kraft P, Zaitlen N. Covariate selection for association screening in multiphenotype genetic studies. Nat Genet. 2017 Dec; 49(12):1789-1795. PMID: 29038595.
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    19. Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ. CRISPR-Cas9-mediated functional dissection of 3'-UTRs. Nucleic Acids Res. 2017 Oct 13; 45(18):10800-10810. PMID: 28985357.
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    20. Wagle M, Nguyen J, Lee S, Zaitlen N, Guo S. Heritable natural variation of an anxiety-like behavior in larval zebrafish. J Neurogenet. 2017 09; 31(3):138-148. PMID: 28678579.
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    21. Rahmani E, Yedidim R, Shenhav L, Schweiger R, Weissbrod O, Zaitlen N, Halperin E. GLINT: a user-friendly toolset for the analysis of high-throughput DNA-methylation array data. Bioinformatics. 2017 Jun 15; 33(12):1870-1872. PMID: 28177067.
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    22. Mitra I, Tsang K, Ladd-Acosta C, Croen LA, Aldinger KA, Hendren RL, Traglia M, Lavillaureix A, Zaitlen N, Oldham MC, Levitt P, Nelson S, Amaral DG, Hertz-Picciotto I, Fallin MD, Weiss LA. Correction: Pleiotropic Mechanisms Indicated for Sex Differences in Autism. PLoS Genet. 2017 Jun; 13(6):e1006831. PMID: 28591140.
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    23. Hoffman JD, Graff RE, Emami NC, Tai CG, Passarelli MN, Hu D, Huntsman S, Hadley D, Leong L, Majumdar A, Zaitlen N, Ziv E, Witte JS. Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk. PLoS Genet. 2017 Mar; 13(3):e1006690. PMID: 28362817.
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    24. Rahmani E, Zaitlen N, Baran Y, Eng C, Hu D, Galanter J, Oh S, Burchard EG, Eskin E, Zou J, Halperin E. Correcting for cell-type heterogeneity in DNA methylation: a comprehensive evaluation. Nat Methods. 2017 02 28; 14(3):218-219. PMID: 28245214.
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    25. Galanter JM, Gignoux CR, Oh SS, Torgerson D, Pino-Yanes M, Thakur N, Eng C, Hu D, Huntsman S, Farber HJ, Avila PC, Brigino-Buenaventura E, LeNoir MA, Meade K, Serebrisky D, Rodríguez-Cintrón W, Kumar R, Rodríguez-Santana JR, Seibold MA, Borrell LN, Burchard EG, Zaitlen N. Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures. Elife. 2017 01 03; 6. PMID: 28044981.
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    26. Rahmani E, Shenhav L, Schweiger R, Yousefi P, Huen K, Eskenazi B, Eng C, Huntsman S, Hu D, Galanter J, Oh SS, Waldenberger M, Strauch K, Grallert H, Meitinger T, Gieger C, Holland N, Burchard EG, Zaitlen N, Halperin E. Genome-wide methylation data mirror ancestry information. Epigenetics Chromatin. 2017; 10:1. PMID: 28149326.
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    27. Hayeck TJ, Loh PR, Pollack S, Gusev A, Patterson N, Zaitlen NA, Price AL. Mixed Model Association with Family-Biased Case-Control Ascertainment. Am J Hum Genet. 2017 Jan 05; 100(1):31-39. PMID: 28017371.
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    28. Traglia M, Bseiso D, Gusev A, Adviento B, Park DS, Mefford JA, Zaitlen N, Weiss LA. Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits. Genetics. 2017 02; 205(2):979-992. PMID: 27974502.
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    29. Zaitlen N, Huntsman S, Hu D, Spear M, Eng C, Oh SS, White MJ, Mak A, Davis A, Meade K, Brigino-Buenaventura E, LeNoir MA, Bibbins-Domingo K, Burchard EG, Halperin E. The Effects of Migration and Assortative Mating on Admixture Linkage Disequilibrium. Genetics. 2017 01; 205(1):375-383. PMID: 27879348.
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    30. Mitra I, Tsang K, Ladd-Acosta C, Croen LA, Aldinger KA, Hendren RL, Traglia M, Lavillaureix A, Zaitlen N, Oldham MC, Levitt P, Nelson S, Amaral DG, Hertz-Picciotto I, Fallin MD, Weiss LA. Pleiotropic Mechanisms Indicated for Sex Differences in Autism. PLoS Genet. 2016 11; 12(11):e1006425. PMID: 27846226.
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    31. Joshi RS, Garg P, Zaitlen N, Lappalainen T, Watson CT, Azam N, Ho D, Li X, Antonarakis SE, Brunner HG, Buiting K, Cheung SW, Coffee B, Eggermann T, Francis D, Geraedts JP, Gimelli G, Jacobson SG, Le Caignec C, de Leeuw N, Liehr T, Mackay DJ, Montgomery SB, Pagnamenta AT, Papenhausen P, Robinson DO, Ruivenkamp C, Schwartz C, Steiner B, Stevenson DA, Surti U, Wassink T, Sharp AJ. DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome. Am J Hum Genet. 2016 09 01; 99(3):555-566. PMID: 27569549.
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    32. Brown BC, Ye CJ, Price AL, Zaitlen N. Transethnic Genetic-Correlation Estimates from Summary Statistics. Am J Hum Genet. 2016 07 07; 99(1):76-88. PMID: 27321947.
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    33. Uricchio LH, Zaitlen NA, Ye CJ, Witte JS, Hernandez RD. Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants. Genome Res. 2016 07; 26(7):863-73. PMID: 27197206.
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    34. Brown BC, Price AL, Patsopoulos NA, Zaitlen N. Local Joint Testing Improves Power and Identifies Hidden Heritability in Association Studies. Genetics. 2016 07; 203(3):1105-16. PMID: 27182951.
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    35. Rahmani E, Zaitlen N, Baran Y, Eng C, Hu D, Galanter J, Oh S, Burchard EG, Eskin E, Zou J, Halperin E. Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies. Nat Methods. 2016 05; 13(5):443-5. PMID: 27018579.
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    36. Biton A, Torgerson D, Letonqueze O, Zhao W, Zaitlen N, Erle DJ. Massively Parallel Identification of Regulatory Variants in Asthma. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S104. PMID: 27027944.
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    37. Balliu B, Zaitlen N. A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies. Genetics. 2016 Apr; 202(4):1289-97. PMID: 26865367.
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    38. Zou JY, Park DS, Burchard EG, Torgerson DG, Pino-Yanes M, Song YS, Sankararaman S, Halperin E, Zaitlen N. Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):13621-6. PMID: 26483472.
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    39. Caswell JL, Camarda R, Zhou AY, Huntsman S, Hu D, Brenner SE, Zaitlen N, Goga A, Ziv E. Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors. Hum Mol Genet. 2015 Dec 20; 24(25):7421-31. PMID: 26472073.
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    40. Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH, Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL. Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Am J Hum Genet. 2015 Oct 01; 97(4):576-92. PMID: 26430803.
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    41. Park DS, Brown B, Eng C, Huntsman S, Hu D, Torgerson DG, Burchard EG, Zaitlen N. Adapt-Mix: learning local genetic correlation structure improves summary statistics-based analyses. Bioinformatics. 2015 Jun 15; 31(12):i181-9. PMID: 26072481.
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    42. Baran Y, Subramaniam M, Biton A, Tukiainen T, Tsang EK, Rivas MA, Pirinen M, Gutierrez-Arcelus M, Smith KS, Kukurba KR, Zhang R, Eng C, Torgerson DG, Urbanek C, Li JB, Rodriguez-Santana JR, Burchard EG, Seibold MA, MacArthur DG, Montgomery SB, Zaitlen NA, Lappalainen T. The landscape of genomic imprinting across diverse adult human tissues. Genome Res. 2015 Jul; 25(7):927-36. PMID: 25953952.
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    43. Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015 Jun; 47(6):654-60. PMID: 25894502.
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    44. Hayeck TJ, Zaitlen NA, Loh PR, Vilhjalmsson B, Pollack S, Gusev A, Yang J, Chen GB, Goddard ME, Visscher PM, Patterson N, Price AL. Mixed model with correction for case-control ascertainment increases association power. Am J Hum Genet. 2015 May 07; 96(5):720-30. PMID: 25892111.
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    45. Pirinen M, Lappalainen T, Zaitlen NA, Dermitzakis ET, Donnelly P, McCarthy MI, Rivas MA. Assessing allele-specific expression across multiple tissues from RNA-seq read data. Bioinformatics. 2015 Aug 01; 31(15):2497-504. PMID: 25819081.
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    46. Park DS, Baran Y, Hormozdiari F, Eng C, Torgerson DG, Burchard EG, Zaitlen N. PIGS: improved estimates of identity-by-descent probabilities by probabilistic IBD graph sampling. BMC Bioinformatics. 2015; 16 Suppl 5:S9. PMID: 25860540.
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    47. Aschard H, Zaitlen N, Lindström S, Kraft P. Variation in predictive ability of common genetic variants by established strata: the example of breast cancer and age. Epidemiology. 2015 Jan; 26(1):51-8. PMID: 25380502.
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    48. Cornelis MC, Zaitlen N, Hu FB, Kraft P, Price AL. Genetic and environmental components of family history in type 2 diabetes. Hum Genet. 2015 Feb; 134(2):259-67. PMID: 25543539.
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    49. Zaitlen N, Pasaniuc B, Sankararaman S, Bhatia G, Zhang J, Gusev A, Young T, Tandon A, Pollack S, Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S, Franceschini N, Goodman PG, He J, Hennis AJ, Hsing A, Ingles SA, Isaacs W, Kittles RA, Klein EA, Lange LA, Nemesure B, Patterson N, Reich D, Rybicki BA, Stanford JL, Stevens VL, Strom SS, Whitsel EA, Witte JS, Xu J, Haiman C, Wilson JG, Kooperberg C, Stram D, Reiner AP, Tang H, Price AL. Leveraging population admixture to characterize the heritability of complex traits. Nat Genet. 2014 Dec; 46(12):1356-62. PMID: 25383972.
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    50. Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N, McCabe C, Lee MH, Frohlich I, Paik HI, Zaitlen N, Hacohen N, Stranger B, De Jager P, Mathis D, Regev A, Benoist C. Intersection of population variation and autoimmunity genetics in human T cell activation. Science. 2014 Sep 12; 345(6202):1254665. PMID: 25214635.
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    51. Pasaniuc B, Zaitlen N, Shi H, Bhatia G, Gusev A, Pickrell J, Hirschhorn J, Strachan DP, Patterson N, Price AL. Fast and accurate imputation of summary statistics enhances evidence of functional enrichment. Bioinformatics. 2014 Oct 15; 30(20):2906-14. PMID: 24990607.
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    52. Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ. Massively parallel functional annotation of 3' untranslated regions. Nat Biotechnol. 2014 Apr; 32(4):387-91. PMID: 24633241.
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    53. Yang J, Zaitlen NA, Goddard ME, Visscher PM, Price AL. Advantages and pitfalls in the application of mixed-model association methods. Nat Genet. 2014 Feb; 46(2):100-6. PMID: 24473328.
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    54. Gusev A, Bhatia G, Zaitlen N, Vilhjalmsson BJ, Diogo D, Stahl EA, Gregersen PK, Worthington J, Klareskog L, Raychaudhuri S, Plenge RM, Pasaniuc B, Price AL. Quantifying missing heritability at known GWAS loci. PLoS Genet. 2013; 9(12):e1003993. PMID: 24385918.
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    55. Chimusa ER, Zaitlen N, Daya M, Möller M, van Helden PD, Mulder NJ, Price AL, Hoal EG. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. Hum Mol Genet. 2014 Feb 01; 23(3):796-809. PMID: 24057671.
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    56. Zaitlen N, Kraft P, Patterson N, Pasaniuc B, Bhatia G, Pollack S, Price AL. Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. PLoS Genet. 2013 May; 9(5):e1003520. PMID: 23737753.
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    57. Pasaniuc B, Sankararaman S, Torgerson DG, Gignoux C, Zaitlen N, Eng C, Rodriguez-Cintron W, Chapela R, Ford JG, Avila PC, Rodriguez-Santana J, Chen GK, Le Marchand L, Henderson B, Reich D, Haiman CA, Gonzàlez Burchard E, Halperin E. Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation. Bioinformatics. 2013 Jun 01; 29(11):1407-15. PMID: 23572411.
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    58. Aschard H, Zaitlen N, Tamimi RM, Lindström S, Kraft P. A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes. Genet Epidemiol. 2013 May; 37(4):323-33. PMID: 23512279.
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    59. Price AL, Zaitlen NA, Reich D, Patterson N. Response to Sul and Eskin. Nat Rev Genet. 2013 Apr; 14(4):300. PMID: 23438870.
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    60. Zaitlen N, Lindström S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeböller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, Landi MT, Langefeld CD, Le Marchand L, Meister M, Morgan AW, Raji OY, Risch A, Rosenberger A, Scherf D, Steer S, Walshaw M, Waters KM, Wilson AG, Wordsworth P, Zienolddiny S, Tchetgen ET, Haiman C, Hunter DJ, Plenge RM, Worthington J, Christiani DC, Schaumberg DA, Chasman DI, Altshuler D, Voight B, Kraft P, Patterson N, Price AL. Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet. 2012; 8(11):e1003032. PMID: 23144628.
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    61. Zaitlen N, Kraft P. Heritability in the genome-wide association era. Hum Genet. 2012 Oct; 131(10):1655-64. PMID: 22821350.
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    62. Pasaniuc B, Rohland N, McLaren PJ, Garimella K, Zaitlen N, Li H, Gupta N, Neale BM, Daly MJ, Sklar P, Sullivan PF, Bergen S, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Purcell SM, Haas DW, Liang L, Sunyaev S, Patterson N, de Bakker PI, Reich D, Price AL. Extremely low-coverage sequencing and imputation increases power for genome-wide association studies. Nat Genet. 2012 May 20; 44(6):631-5. PMID: 22610117.
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    63. Zaitlen N, Pasaniuc B, Patterson N, Pollack S, Voight B, Groop L, Altshuler D, Henderson BE, Kolonel LN, Le Marchand L, Waters K, Haiman CA, Stranger BE, Dermitzakis ET, Kraft P, Price AL. Analysis of case-control association studies with known risk variants. Bioinformatics. 2012 Jul 01; 28(13):1729-37. PMID: 22556366.
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    64. Aschard H, Qiu W, Pasaniuc B, Zaitlen N, Cho MH, Carey V. Combining effects from rare and common genetic variants in an exome-wide association study of sequence data. BMC Proc. 2011 Nov 29; 5 Suppl 9:S44. PMID: 22373328.
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    65. Bhatia G, Patterson N, Pasaniuc B, Zaitlen N, Genovese G, Pollack S, Mallick S, Myers S, Tandon A, Spencer C, Palmer CD, Adeyemo AA, Akylbekova EL, Cupples LA, Divers J, Fornage M, Kao WH, Lange L, Li M, Musani S, Mychaleckyj JC, Ogunniyi A, Papanicolaou G, Rotimi CN, Rotter JI, Ruczinski I, Salako B, Siscovick DS, Tayo BO, Yang Q, McCarroll S, Sabeti P, Lettre G, De Jager P, Hirschhorn J, Zhu X, Cooper R, Reich D, Wilson JG, Price AL. Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection. Am J Hum Genet. 2011 Sep 09; 89(3):368-81. PMID: 21907010.
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    66. He D, Zaitlen N, Pasaniuc B, Eskin E, Halperin E. Genotyping common and rare variation using overlapping pool sequencing. BMC Bioinformatics. 2011; 12 Suppl 6:S2. PMID: 21989232.
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    67. Pasaniuc B, Zaitlen N, Lettre G, Chen GK, Tandon A, Kao WH, Ruczinski I, Fornage M, Siscovick DS, Zhu X, Larkin E, Lange LA, Cupples LA, Yang Q, Akylbekova EL, Musani SK, Divers J, Mychaleckyj J, Li M, Papanicolaou GJ, Millikan RC, Ambrosone CB, John EM, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Nyante SJ, Bandera EV, Ingles SA, Press MF, Chanock SJ, Deming SL, Rodriguez-Gil JL, Palmer CD, Buxbaum S, Ekunwe L, Hirschhorn JN, Henderson BE, Myers S, Haiman CA, Reich D, Patterson N, Wilson JG, Price AL. Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet. 2011 Apr; 7(4):e1001371. PMID: 21541012.
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    68. Pasaniuc B, Zaitlen N, Halperin E. Accurate estimation of expression levels of homologous genes in RNA-seq experiments. J Comput Biol. 2011 Mar; 18(3):459-68. PMID: 21385047.
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