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Olga Tymofiyeva, PhD

Title(s)Assistant Researcher, Radiology
SchoolSchool of Medicine
Phone415-514-4870
ORCID ORCID Icon0000-0003-2589-1041 Additional info
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    Collapse Biography 
    Collapse Education and Training
    National Technical University of Ukraine “KPI”, UkraineB.Sc.2002Electrical Engineering
    Karlsruhe University of Applied Sciences, GermanyM.Sc. 2005Electrical Engineering
    University of Würzburg, GermanyPh.D. 2010Physics
    University of California, San Francisco, USAPostdoctoral training2014Biomedical Imaging
    University of Hagen (distant learning), GermanyB.Sc.2018Psychology
    Collapse Awards and Honors
    DAAD2003  - 2005DAAD-Siemens scholarship for Master Studies
    ESMRMB2009Young Investigator Award, 1st Place
    UCSF2011Surbeck Young Investigators Award, 2nd place
    UCSF2011Outstanding Oral Presentation Award
    UCSF2012Outstanding Poster Presentation Award
    UCSF2013Surbeck Young Investigators Award, 3rd place

    Collapse Overview 
    Collapse Overview
    Dr. Olga Tymofiyeva is an Assistant Professional Researcher in the UCSF Department of Radiology and Biomedical Imaging. Dr. Tymofiyeva holds her degrees in Physics (PhD, University of Wuerzburg, Germany), Electrical Engineering (MSc, University of Applied Sciences, Karlsruhe, Germany and BSc, NTUU “KPI”, Kyiv, Ukraine), and Psychology (BSc, University of Hagen, Germany). Her main research interest is non-invasive mapping of structural and functional connectivity in the developing brain, from premature neonates to adolescents and young adults. She develops and applies advanced MRI techniques to study the neurobiological substrates of mental disorders (in particular, adolescent depression) and effects of mind-body interventions on children and adolescents. Dr. Tymofiyeva is currently the Principal Investigator for an NIH-funded study of brain plasticity in adolescents undergoing a mindfulness meditation training, the "BrainChange" study: https://radiology.ucsf.edu/research/labs/BrainChange.

    Collapse Research 
    Collapse Research Activities and Funding
    Neural mechanisms of meditation training in healthy and depressed adolescents: An MRI connectome study
    NIH/NCCIH R61AT009864Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    A Network Approach to Study Brain Plasticity in Children with Cognitive Training
    NIH/NCCIH R21AT009173Dec 7, 2015 - Nov 30, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Olga Tymofiyeva, Justin Yuan, Roma Kidambi, Chiung-Yu Huang, Eva Henje Blom, Mark Rubinstein, Duan Xu, Tony T. Yang. 4.32 SMARTPHONE DEPENDENCE, BRAIN CONNECTIVITY, AND LINKS TO DEPRESSION IN ADOLESCENTS. Journal of the American Academy of Child & Adolescent Psychiatry. 2019 Oct 1; 58(10):s229-s230.
      View in: Publisher Site
    2. Tymofiyeva O, Yuan JP, Huang CY, Connolly CG, Henje Blom E, Xu D, Yang TT. Application of machine learning to structural connectome to predict symptom reduction in depressed adolescents with cognitive behavioral therapy (CBT). Neuroimage Clin. 2019; 23:101914. PMID: 31491813.
      View in: PubMed
    3. Justin Yuan, Melanie Morrison, Angela Jakary, Sabine Mueller, Olga Tymofiyeva, Duan Xu, Janine Lupo. MEDU-15. STRUCTURAL BRAIN NETWORK PROPERTIES AND COGNITIVE IMPAIRMENT IN ADOLESCENTS AFTER RADIATION THERAPY. Neuro-Oncology. 2019 Apr 23; 21(Supplement_2):ii106-ii106.
      View in: Publisher Site
    4. Yuan JP, Henje Blom E, Flynn T, Chen Y, Ho TC, Connolly CG, Dumont Walter RA, Yang TT, Xu D, Tymofiyeva O. Test-Retest Reliability of Graph Theoretic Metrics in Adolescent Brains. Brain Connect. 2019 03; 9(2):144-154. PMID: 30398373.
      View in: PubMed
    5. Tymofiyeva O, Gano D, Trevino RJ, Glass HC, Flynn T, Lundy SM, McQuillen PS, Ferriero DM, Barkovich AJ, Xu D. Aberrant Structural Brain Connectivity in Adolescents with Attentional Problems Who Were Born Prematurely. AJNR Am J Neuroradiol. 2018 11; 39(11):2140-2147. PMID: 30337433.
      View in: PubMed
    6. Olga Tymofiyeva, Justin Yuan, Colm Connolly, Eva Henje Blom, Duan Xu, Tony T. Yang. 5.48 Using MRI to Predict Depression Symptom Improvement in Depressed Adolescents Undergoing Cbt. Journal of the American Academy of Child & Adolescent Psychiatry. 2018 Oct 1; 57(10):s242.
      View in: Publisher Site
    7. LeWinn KZ, Strigo IA, Connolly CG, Ho TC, Tymofiyeva O, Sacchet MD, Weng HY, Blom EH, Simmons AN, Yang TT. An exploratory examination of reappraisal success in depressed adolescents: Preliminary evidence of functional differences in cognitive control brain regions. J Affect Disord. 2018 11; 240:155-164. PMID: 30071419.
      View in: PubMed
    8. J.C. Nelson, Scott Mackin, Duygu Tosun, Olga Tymofiyeva. Session 112 Emerging Multimodal Neuroimaging Findings in LATE Life Depression. American Journal of Geriatric Psychiatry. 2018 Mar 1; 26(3):s11-s12.
      View in: Publisher Site
    9. Tymofiyeva O, Henje Blom E, Ho TC, Connolly CG, Lindqvist D, Wolkowitz OM, Lin J, LeWinn KZ, Sacchet MD, Han LKM, Yuan JP, Bhandari SP, Xu D, Yang TT. High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression. J Affect Disord. 2018 05; 232:283-290. PMID: 29500956.
      View in: PubMed
    10. Boldt J, Rottner K, Schmitter M, Hopfgartner A, Jakob P, Richter EJ, Tymofiyeva O. High-resolution MR imaging for dental impressions: a feasibility study. Clin Oral Investig. 2018 Apr; 22(3):1209-1213. PMID: 28929419.
      View in: PubMed
    11. Ho TC, Sacchet MD, Connolly CG, Margulies DS, Tymofiyeva O, Paulus MP, Simmons AN, Gotlib IH, Yang TT. Inflexible Functional Connectivity of the Dorsal Anterior Cingulate Cortex in Adolescent Major Depressive Disorder. Neuropsychopharmacology. 2017 Nov; 42(12):2434-2445. PMID: 28553837.
      View in: PubMed
    12. Henje Blom E, Tymofiyeva O, Chesney MA, Ho TC, Moran P, Connolly CG, Duncan LG, Baldini L, Weng HY, Acree M, Goldman V, Hecht FM, Yang TT. Feasibility and Preliminary Efficacy of a Novel RDoC-Based Treatment Program for Adolescent Depression: "Training for Awareness Resilience and Action" (TARA)-A Pilot Study. Front Psychiatry. 2016; 7:208. PMID: 28138319.
      View in: PubMed
    13. Cui J, Tymofiyeva O, Desikan R, Flynn T, Kim H, Gano D, Hess CP, Ferriero DM, Barkovich AJ, Xu D. Microstructure of the Default Mode Network in Preterm Infants. AJNR Am J Neuroradiol. 2017 Feb; 38(2):343-348. PMID: 28059709.
      View in: PubMed
    14. Connolly CG, Ho TC, Blom EH, LeWinn KZ, Sacchet MD, Tymofiyeva O, Simmons AN, Yang TT. Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression. J Affect Disord. 2017 Jan 01; 207:86-94. PMID: 27716542.
      View in: PubMed
    15. Tymofiyeva O, Connolly CG, Ho TC, Sacchet MD, Henje Blom E, LeWinn KZ, Xu D, Yang TT. DTI-based connectome analysis of adolescents with major depressive disorder reveals hypoconnectivity of the right caudate. J Affect Disord. 2017 Jan 01; 207:18-25. PMID: 27673479.
      View in: PubMed
    16. Sacchet MD, Ho TC, Connolly CG, Tymofiyeva O, Lewinn KZ, Han LK, Blom EH, Tapert SF, Max JE, Frank GK, Paulus MP, Simmons AN, Gotlib IH, Yang TT. Large-Scale Hypoconnectivity Between Resting-State Functional Networks in Unmedicated Adolescent Major Depressive Disorder. Neuropsychopharmacology. 2016 11; 41(12):2951-2960. PMID: 27238621.
      View in: PubMed
    17. Henje Blom E, Ho TC, Connolly CG, LeWinn KZ, Sacchet MD, Tymofiyeva O, Weng HY, Yang TT. The neuroscience and context of adolescent depression. Acta Paediatr. 2016 Apr; 105(4):358-65. PMID: 26663379.
      View in: PubMed
    18. Chen Y, Tymofiyeva O, Hess CP, Xu D. Effects of rejecting diffusion directions on tensor-derived parameters. Neuroimage. 2015 Apr 01; 109:160-70. PMID: 25585018.
      View in: PubMed
    19. Tymofiyeva O, Hess CP, Xu D, Barkovich AJ. Structural MRI connectome in development: challenges of the changing brain. Br J Radiol. 2014 Jul; 87(1039):20140086. PMID: 24827379.
      View in: PubMed
    20. Tymofiyeva O, Ziv E, Barkovich AJ, Hess CP, Xu D. Brain without anatomy: construction and comparison of fully network-driven structural MRI connectomes. PLoS One. 2014; 9(5):e96196. PMID: 24789312.
      View in: PubMed
    21. Ziv E, Tymofiyeva O, Ferriero DM, Barkovich AJ, Hess CP, Xu D. A machine learning approach to automated structural network analysis: application to neonatal encephalopathy. PLoS One. 2013; 8(11):e78824. PMID: 24282501.
      View in: PubMed
    22. Hopfgartner AJ, Tymofiyeva O, Ehses P, Rottner K, Boldt J, Richter EJ, Jakob PM. Dynamic MRI of the TMJ under physical load. Dentomaxillofac Radiol. 2013; 42(9):20120436. PMID: 23975114.
      View in: PubMed
    23. Tymofiyeva O, Hess CP, Ziv E, Lee PN, Glass HC, Ferriero DM, Barkovich AJ, Xu D. A DTI-based template-free cortical connectome study of brain maturation. PLoS One. 2013; 8(5):e63310. PMID: 23675475.
      View in: PubMed
    24. Tymofiyeva O, Vaegler S, Rottner K, Boldt J, Hopfgartner AJ, Proff PC, Richter EJ, Jakob PM. Influence of dental materials on dental MRI. Dentomaxillofac Radiol. 2013; 42(6):20120271. PMID: 23610088.
      View in: PubMed
    25. Tymofiyeva O, Proff PC, Rottner K, Düring M, Jakob PM, Richter EJ. Diagnosis of dental abnormalities in children using 3-dimensional magnetic resonance imaging. J Oral Maxillofac Surg. 2013 Jul; 71(7):1159-69. PMID: 23611603.
      View in: PubMed
    26. Tymofiyeva O, Hess CP, Ziv E, Tian N, Bonifacio SL, McQuillen PS, Ferriero DM, Barkovich AJ, Xu D. Towards the "baby connectome": mapping the structural connectivity of the newborn brain. PLoS One. 2012; 7(2):e31029. PMID: 22347423.
      View in: PubMed
    27. Tymofiyeva O, Schmid F, von Kienlin M, Breuer FA, Rottner K, Boldt J, Richter EJ, Jakob PM. On precise localization of boundaries between extended uniform objects in MRI: tooth imaging as an example. MAGMA. 2011 Feb; 24(1):19-28. PMID: 20878537.
      View in: PubMed
    28. Tymofiyeva O, Boldt J, Rottner K, Schmid F, Richter EJ, Jakob PM. High-resolution 3D magnetic resonance imaging and quantification of carious lesions and dental pulp in vivo. MAGMA. 2009 Dec; 22(6):365-74. PMID: 19924456.
      View in: PubMed
    29. Tymofiyeva O, Rottner K, Jakob PM, Richter EJ, Proff P. Three-dimensional localization of impacted teeth using magnetic resonance imaging. Clin Oral Investig. 2010 Apr; 14(2):169-76. PMID: 19399539.
      View in: PubMed
    30. O. Tymofiyeva, K. Rottner, J. Boldt, F. Schmid, E. -J. Richter, P. M. Jakob. In Vivo 3D Imaging of Carious Lesions and Dental Pulp Using Magnetic Resonance. World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. 2009 Jan 1; 25/11:216-218.
      View in: Publisher Site
    31. O. Tymofiyeva, K. Rottner, D. Gareis, J. Boldt, F. Schmid, M.A. Lopez, E.-J. Richter, P.M. Jakob. In vivo MRI-based dental impression using an intraoral RF receiver coil. Concepts in Magnetic Resonance Part B. 2008 Oct 1; 33B(4):244-251.
      View in: Publisher Site
    32. Tymofiyeva O, Rottner K, Gareis D, Boldt J, Schmid F, Lopez MA, Richter E-J, Jakob PM.In vivo MRI-based dental impression using an intraoral RF receiver coil. Concept Magn Reson B: Magn Reson Eng. 2008; (33B):244-251.
    33. Tymofiyeva O, Proff P, Richter EJ, Jakob P, Fanghänel J, Gedrange T, Rottner K. Correlation of MRT imaging with real-time axiography of TMJ clicks. Ann Anat. 2007; 189(4):356-61. PMID: 17695992.
      View in: PubMed