Panos Theofilas, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of Edinburgh, UKBSc09/2003Zoology
    University of Edinburgh, UKMSc09/2004Integrative Neuroscience
    University of Bonn, GermanyPhD08/2009Cell death pathways in Epilepsy
    Legacy Health Research, OR, USA03/2012Postdoc: Gene therapy in Epilepsy
    UC San Francisco, CA, USA06/2017Postdoc: Neuropathology of Alzheimer's disease

    Collapse Overview 
    Collapse Overview
    Dr. Theofilas is Assistant Professor at the Memory and Aging Center, UCSF. He obtained his bachelor and masters’ degrees in Neuroscience at the University of Edinburgh, UK, and his doctorate at the University of Bonn, Germany, studying apoptosis signaling pathways, mitochondria dysfunction and excitotoxicity in animal models of epilepsy.
    In 2012, Dr. Theofilas joined Lea Grinberg’s lab at UCSF to study a network of subcortical nuclei of the isodentritic core in the human brainstem that shows the earliest neurofibrillary changes in individuals with Alzheimer’s disease. He conducted integrative analyses of neuronal loss and tangle accumulation in the locus coeruleus and dorsal raphe nucleus using unbiased stereology with immunohistochemistry and advanced graphics computing for three-dimensional brainstem volume reconstructions.
    Dr. Theofilas is currently a principal investigator in a study focusing on cell death pathways and their relationship to tau pathology in patients with AD and iPSC culture models. He is particularly interested in proteasome and apoptosis/caspase-related pathways and how these correlate to tau post-translational modifications, tau aggregation, and neurotoxicity in AD.

    Collapse Research 
    Collapse Research Activities and Funding
    Tau-mediated caspase activation in Alzheimer's disease postmortem brains and patient-derived iPSCs.
    UCSF RAP Pilot Award for Junior Investigators UCSF RAPJul 1, 2019 - Jun 30, 2020
    Role: Principal Investigator
    The role of cell death pathways in mediating neuronal loss during the earliest stages of Alzheimer disease
    NIH K01AG053433Jul 1, 2017 - May 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT. Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study. J Neuropathol Exp Neurol. 2018 Feb 01; 77(2):149-161. PMID: 29304218.
      View in: PubMed
    2. Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging. 2018 01; 61:1-12. PMID: 29031088.
      View in: PubMed
    3. Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rüb U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT. Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease. Neuropathol Appl Neurobiol. 2017 Aug; 43(5):393-408. PMID: 28117917.
      View in: PubMed
    4. Theofilas P, Steinhäuser C, Theis M, Derouiche A. Morphological study of a connexin 43-GFP reporter mouse highlights glial heterogeneity, amacrine cells, and olfactory ensheathing cells. J Neurosci Res. 2017 11; 95(11):2182-2194. PMID: 28370142.
      View in: PubMed
    5. Alegro M, Theofilas P, Nguy A, Castruita PA, Seeley W, Heinsen H, Ushizima DM, Grinberg LT. Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding. J Neurosci Methods. 2017 Apr 15; 282:20-33. PMID: 28267565.
      View in: PubMed
    6. Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Jacob Filho W, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery. Alzheimers Dement. 2017 Mar; 13(3):236-246. PMID: 27513978.
      View in: PubMed
    7. Theofilas P, Dunlop S, Heinsen H, Grinberg LT. Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease Pathogenesis. J Alzheimers Dis. 2015; 46(1):17-34. PMID: 25720408.
      View in: PubMed
    8. Theofilas P, Polichiso L, Wang X, Lima LC, Alho AT, Leite RE, Suemoto CK, Pasqualucci CA, Jacob-Filho W, Heinsen H, Grinberg LT. A novel approach for integrative studies on neurodegenerative diseases in human brains. J Neurosci Methods. 2014 Apr 15; 226:171-83. PMID: 24503023.
      View in: PubMed
    9. Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. Acta Neuropathol. 2013 Apr; 125(4):581-93. PMID: 23371364; PMCID: PMC3692283.
    10. Diógenes MJ, Neves-Tomé R, Fucile S, Martinello K, Scianni M, Theofilas P, Lopatár J, Ribeiro JA, Maggi L, Frenguelli BG, Limatola C, Boison D, Sebastião AM. Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex. 2014 Jan; 24(1):67-80. PMID: 22997174; PMCID: PMC3862265.
    11. Lusardi TA, Thompson SJ, MacDonald IC, Lan JQ, Theofilas P, Saugstad JA. Effect of (S)-3,5-DHPG on microRNA expression in mouse brain. Exp Neurol. 2012 Jun; 235(2):497-507. PMID: 22309833; PMCID: PMC3345043.
    12. Masino SA, Li T, Theofilas P, Sandau US, Ruskin DN, Fredholm BB, Geiger JD, Aronica E, Boison D. A ketogenic diet suppresses seizures in mice through adenosine A1 receptors. J Clin Invest. 2011 Jul; 121(7):2679-83. PMID: 21701065; PMCID: PMC3223846.
    13. Theofilas P, Brar S, Stewart KA, Shen HY, Sandau US, Poulsen D, Boison D. Adenosine kinase as a target for therapeutic antisense strategies in epilepsy. Epilepsia. 2011 Mar; 52(3):589-601. PMID: 21275977; PMCID: PMC3075862.
    14. Van Dycke A, Raedt R, Verstraete A, Theofilas P, Wadman W, Vonck K, Boison D, Boon P. Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery. Seizure. 2010 Sep; 19(7):390-6. PMID: 20688264; PMCID: PMC2953799.
    15. Theofilas P, Bedner P, Hüttmann K, Theis M, Steinhäuser C, Frank S. The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell death. J Neuropathol Exp Neurol. 2009 Jan; 68(1):102-10. PMID: 19104441.
      View in: PubMed
    16. Ainge JA, Heron-Maxwell C, Theofilas P, Wright P, de Hoz L, Wood ER. The role of the hippocampus in object recognition in rats: examination of the influence of task parameters and lesion size. Behav Brain Res. 2006 Feb 15; 167(1):183-95. PMID: 16214239.
      View in: PubMed