Dr. Theofilas is Assistant Professor at the Memory and Aging Center, UCSF. He obtained his bachelor and masters’ degrees in Neuroscience at the University of Edinburgh, UK, and his doctorate at the University of Bonn, Germany, studying apoptosis signaling pathways, mitochondria dysfunction and excitotoxicity in animal models of epilepsy.
In 2012, Dr. Theofilas joined Lea Grinberg’s lab at UCSF to study a network of subcortical nuclei of the isodentritic core in the human brainstem that shows the earliest neurofibrillary changes in individuals with Alzheimer’s disease. He conducted integrative analyses of neuronal loss and tangle accumulation in the locus coeruleus and dorsal raphe nucleus using unbiased stereology with immunohistochemistry and advanced graphics computing for three-dimensional brainstem volume reconstructions.
Dr. Theofilas is currently a principal investigator in a study focusing on cell death pathways and their relationship to tau pathology in patients with AD and iPSC culture models. He is particularly interested in proteasome and apoptosis/caspase-related pathways and how these correlate to tau post-translational modifications, tau aggregation, and neurotoxicity in AD.