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Panos Theofilas, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-502-7174
EmailPanos.Theofilas@ucsf.edu
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of Edinburgh, UKBSc09/2003Zoology
    University of Edinburgh, UKMSc09/2004Neuroscience
    University of Bonn, GermanyPhD08/2009Cell death pathways in Epilepsy

    Collapse Overview 
    Collapse Overview
    Dr. Theofilas is Assistant Professor at the Memory and Aging Center, UCSF. He obtained his bachelor and masters’ degrees in Neuroscience at the University of Edinburgh, UK, and his doctorate at the University of Bonn, Germany, studying apoptosis signaling pathways, mitochondria dysfunction and excitotoxicity in animal models of epilepsy.
    In 2012, Dr. Theofilas joined Lea Grinberg’s lab at UCSF to study a network of subcortical nuclei of the isodentritic core in the human brainstem that shows the earliest neurofibrillary changes in individuals with Alzheimer’s disease. He conducted integrative analyses of neuronal loss and tangle accumulation in the locus coeruleus and dorsal raphe nucleus using unbiased stereology with immunohistochemistry and advanced graphics computing for three-dimensional brainstem volume reconstructions.
    Dr. Theofilas is currently a principal investigator in a study focusing on cell death pathways and their relationship to tau pathology in patients with AD and iPSC culture models. He is particularly interested in proteasome and apoptosis/caspase-related pathways and how these correlate to tau post-translational modifications, tau aggregation, and neurotoxicity in AD.

    Collapse Research 
    Collapse Research Activities and Funding
    Tau-mediated caspase activation in Alzheimer's disease postmortem brains and patient-derived iPSCs.
    UCSF RAP Pilot Award for Junior Investigators UCSF RAPJul 1, 2019 - Jun 30, 2020
    Role: Principal Investigator
    The role of cell death pathways in mediating neuronal loss during the earliest stages of Alzheimer disease
    NIH K01AG053433Jul 1, 2017 - May 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. 2019 11 12; 13(5):939-955. Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S. PMID: 31631020.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Profound degeneration of wake-promoting neurons in Alzheimer's disease. Alzheimers Dement. 2019 10; 15(10):1253-1263. Oh J, Eser RA, Ehrenberg AJ, Morales D, Petersen C, Kudlacek J, Dunlop SR, Theofilas P, Resende EDPF, Cosme C, Alho EJL, Spina S, Walsh CM, Miller BL, Seeley WW, Bittencourt JC, Neylan TC, Heinsen H, Grinberg LT. PMID: 31416793.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat Chem Biol. 2019 08; 15(8):786-794. Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. PMID: 31320752.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    4. Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study. J Neuropathol Exp Neurol. 2018 02 01; 77(2):149-161. Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT. PMID: 29304218.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    5. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging. 2018 01; 61:1-12. Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. PMID: 29031088.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    6. Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease. Neuropathol Appl Neurobiol. 2017 Aug; 43(5):393-408. Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rüb U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT. PMID: 28117917.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    7. Morphological study of a connexin 43-GFP reporter mouse highlights glial heterogeneity, amacrine cells, and olfactory ensheathing cells. J Neurosci Res. 2017 11; 95(11):2182-2194. Theofilas P, Steinhäuser C, Theis M, Derouiche A. PMID: 28370142.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding. J Neurosci Methods. 2017 Apr 15; 282:20-33. Alegro M, Theofilas P, Nguy A, Castruita PA, Seeley W, Heinsen H, Ushizima DM, Grinberg LT. PMID: 28267565.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery. Alzheimers Dement. 2017 Mar; 13(3):236-246. Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Jacob Filho W, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. PMID: 27513978.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    10. Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease Pathogenesis. J Alzheimers Dis. 2015; 46(1):17-34. Theofilas P, Dunlop S, Heinsen H, Grinberg LT. PMID: 25720408.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    11. A novel approach for integrative studies on neurodegenerative diseases in human brains. J Neurosci Methods. 2014 Apr 15; 226:171-183. Theofilas P, Polichiso L, Wang X, Lima LC, Alho ATL, Leite REP, Suemoto CK, Pasqualucci CA, Jacob-Filho W, Heinsen H, Grinberg LT. PMID: 24503023.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    12. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. Acta Neuropathol. 2013 Apr; 125(4):581-93. Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW. PMID: 23371364.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    13. Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex. 2014 Jan; 24(1):67-80. Diógenes MJ, Neves-Tomé R, Fucile S, Martinello K, Scianni M, Theofilas P, Lopatár J, Ribeiro JA, Maggi L, Frenguelli BG, Limatola C, Boison D, Sebastião AM. PMID: 22997174.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    14. Effect of (S)-3,5-DHPG on microRNA expression in mouse brain. Exp Neurol. 2012 Jun; 235(2):497-507. Lusardi TA, Thompson SJ, MacDonald IC, Lan JQ, Theofilas P, Saugstad JA. PMID: 22309833.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    15. A ketogenic diet suppresses seizures in mice through adenosine A1 receptors. J Clin Invest. 2011 Jul; 121(7):2679-83. Masino SA, Li T, Theofilas P, Sandau US, Ruskin DN, Fredholm BB, Geiger JD, Aronica E, Boison D. PMID: 21701065.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimals
    16. Adenosine kinase as a target for therapeutic antisense strategies in epilepsy. Epilepsia. 2011 Mar; 52(3):589-601. Theofilas P, Brar S, Stewart KA, Shen HY, Sandau US, Poulsen D, Boison D. PMID: 21275977.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    17. Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery. Seizure. 2010 Sep; 19(7):390-6. Van Dycke A, Raedt R, Verstraete A, Theofilas P, Wadman W, Vonck K, Boison D, Boon P. PMID: 20688264.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell death. J Neuropathol Exp Neurol. 2009 Jan; 68(1):102-10. Theofilas P, Bedner P, Hüttmann K, Theis M, Steinhäuser C, Frank S. PMID: 19104441.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    19. The role of the hippocampus in object recognition in rats: examination of the influence of task parameters and lesion size. Behav Brain Res. 2006 Feb 15; 167(1):183-95. Ainge JA, Heron-Maxwell C, Theofilas P, Wright P, de Hoz L, Wood ER. PMID: 16214239.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
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