Pao-Tien Chuang, MD, PhD

SchoolUCSF School of Medicine
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Sufu-interacting proteins provide novel insight into mammalian Hedgehog signaling
    NIH/NIGMS R01GM110487Jun 1, 2015 - May 31, 2019
    Role: Principal Investigator
    The lineage and function of neuroendocrine cells in lung homeostasis and injury
    NIH/NHLBI R01HL115207Jul 1, 2013 - Jun 30, 2017
    Role: Principal Investigator
    Epithelial Progenitor Cells in Lung Repair and Regeneration
    NIH/NHLBI U01HL111054Jan 1, 2012 - Dec 31, 2016
    Role: Co-Principal Investigator
    The molecular mechanisms by which mammalian Fused regulates motile cilia function
    NIH/NHLBI R01HL091915Dec 12, 2008 - Nov 30, 2013
    Role: Principal Investigator
    Molecular Mechanisms of Mammalian Hedgehog Signal Transduction
    NIH/NIGMS R01GM085097Aug 1, 2008 - Jul 31, 2013
    Role: Principal Investigator
    Control of Hedgehog protein gradient formation in vertebrates
    NIH/NHLBI R01HL067822Jul 1, 2001 - Mar 31, 2013
    Role: Principal Investigator
    Development and Control of Pulmonary alveolar Stability
    NIH P01HL024075Jul 1, 1979 - Dec 31, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lin C, Tsai M, Chen W, Chuang P, Tang C. Comparative Effectiveness of Triple Antihypertensive Combination Therapy for Patients with Resistant Hypertension In Taiwan. Value Health. 2015 Nov; 18(7):A375. PMID: 26532121.
      View in: PubMed
    2. Lin C, Yao E, Chuang P. A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 1; 403(1):101-13. PMID: 25912685; PMCID: PMC4469623 [Available on 07/01/16].
    3. Yao E, Chuang P. Hedgehog signaling: From basic research to clinical applications. J Formos Med Assoc. 2015 Jul; 114(7):569-76. PMID: 25701396.
      View in: PubMed
    4. Lin C, Yao E, Wang K, Nozawa Y, Shimizu H, Johnson JR, Chen JN, Krogan NJ, Chuang P. Regulation of Sufu activity by p66ß and Mycbp provides new insight into vertebrate Hedgehog signaling. Genes Dev. 2014 Nov 15; 28(22):2547-63. PMID: 25403183; PMCID: PMC4233246.
    5. Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, Chuang P. Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Dev Biol. 2014 Aug 15; 392(2):324-33. PMID: 24886827; PMCID: PMC4106470.
    6. Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang P, Hopyan S, Hui CC. A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28; 29(2):241-9. PMID: 24726283.
      View in: PubMed
    7. Nozawa YI, Yao E, Gacayan R, Xu SM, Chuang P. Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis. Dev Biol. 2014 Apr 15; 388(2):170-80. PMID: 24525297; PMCID: PMC3982599.
    8. Nozawa YI, Yao E, Lin C, Yang JH, Wilson CW, Gacayan R, Chuang P. Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct. Dev Dyn. 2013 Nov; 242(11):1307-19. PMID: 23907739.
      View in: PubMed
    9. Nozawa YI, Lin C, Chuang P. Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction. Curr Opin Genet Dev. 2013 Aug; 23(4):429-37. PMID: 23725801; PMCID: PMC3913210.
    10. Lin C, Song H, Huang C, Yao E, Gacayan R, Xu SM, Chuang P. Alveolar type II cells possess the capability of initiating lung tumor development. PLoS One. 2012; 7(12):e53817. PMID: 23285300; PMCID: PMC3527621.
    11. Song H, Yao E, Lin C, Gacayan R, Chen MH, Chuang P. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17531-6. PMID: 23047698; PMCID: PMC3491514.
    12. Lin C, Nozawa YI, Chuang P. The path to chemotaxis and transcription is smoothened. Sci Signal. 2012 Aug 21; 5(238):pe35. PMID: 22912492.
      View in: PubMed
    13. Engel BD, Ishikawa H, Feldman JL, Wilson CW, Chuang P, Snedecor J, Williams J, Sun Z, Marshall WF. A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow. Cytoskeleton (Hoboken). 2011 Mar; 68(3):188-203. PMID: 21360831.
      View in: PubMed
    14. Wilson CW, Chuang P. Mechanism and evolution of cytosolic Hedgehog signal transduction. Development. 2010 Jul; 137(13):2079-94. PMID: 20530542; PMCID: PMC2882129.
    15. Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang P. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009 Aug 15; 23(16):1910-28. PMID: 19684112; PMCID: PMC2725943.
    16. Wilson CW, Chen MH, Chuang P. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One. 2009; 4(4):e5182. PMID: 19365551; PMCID: PMC2664476.
    17. Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang P. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature. 2009 May 7; 459(7243):98-102. PMID: 19305393; PMCID: PMC3204898.
    18. Mak KK, Bi Y, Wan C, Chuang P, Clemens T, Young M, Yang Y. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev Cell. 2008 May; 14(5):674-88. PMID: 18477451.
      View in: PubMed
    19. Mak KK, Kronenberg HM, Chuang P, Mackem S, Yang Y. Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development. 2008 Jun; 135(11):1947-56. PMID: 18434416.
      View in: PubMed
    20. Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen MH, Chuang P, Reiter JF. Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol. 2008 Jan; 10(1):70-6. PMID: 18084282.
      View in: PubMed
    21. Chen MH, Wilson CW, Chuang P. SnapShot: hedgehog signaling pathway. Cell. 2007 Jul 27; 130(2):386. PMID: 17662951.
      View in: PubMed
    22. Gerber AN, Wilson CW, Li YJ, Chuang P. The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation. Oncogene. 2007 Feb 22; 26(8):1122-36. PMID: 16964293; PMCID: PMC3325095.
    23. Mak KK, Chen MH, Day TF, Chuang P, Yang Y. Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development. 2006 Sep; 133(18):3695-707. PMID: 16936073.
      View in: PubMed
    24. Ochi H, Pearson BJ, Chuang P, Hammerschmidt M, Westerfield M. Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened. Dev Biol. 2006 Sep 1; 297(1):127-40. PMID: 16765934.
      View in: PubMed
    25. Wilson CW, Chuang P. New "hogs" in Hedgehog transport and signal reception. Cell. 2006 May 5; 125(3):435-8. PMID: 16678090.
      View in: PubMed
    26. Dai T, Natarajan R, Nast CC, LaPage J, Chuang P, Sim J, Tong L, Chamberlin M, Wang S, Adler SG. Glucose and diabetes: effects on podocyte and glomerular p38MAPK, heat shock protein 25, and actin cytoskeleton. Kidney Int. 2006 Mar; 69(5):806-14. PMID: 16421517.
      View in: PubMed
    27. Hu MC, Mo R, Bhella S, Wilson CW, Chuang P, Hui CC, Rosenblum ND. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development. 2006 Feb; 133(3):569-78. PMID: 16396903.
      View in: PubMed
    28. Chen MH, Gao N, Kawakami T, Chuang P. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol Cell Biol. 2005 Aug; 25(16):7042-53. PMID: 16055716; PMCID: PMC1190231.
    29. Yang SH, Shrivastav A, Kosinski C, Sharma RK, Chen MH, Berthiaume LG, Peters LL, Chuang P, Young SG, Bergo MO. N-myristoyltransferase 1 is essential in early mouse development. J Biol Chem. 2005 May 13; 280(19):18990-5. PMID: 15753093.
      View in: PubMed
    30. Chen MH, Li YJ, Kawakami T, Xu SM, Chuang P. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15; 18(6):641-59. PMID: 15075292; PMCID: PMC387240.
    31. Vogt A, Chuang P, Hebert J, Hwang J, Lu Y, Kopelovich L, Athar M, Bickers DR, Epstein EH. Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. J Exp Med. 2004 Mar 15; 199(6):753-61. PMID: 15024045; PMCID: PMC2212732.
    32. Wang JY, Chuang P, Lin CJ, Yu CJ, Yang PC. Continuous lateral rotational therapy in the medical intensive care unit. J Formos Med Assoc. 2003 Nov; 102(11):788-92. PMID: 14724725.
      View in: PubMed
    33. Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang P, Hebrok M. Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development. 2003 Oct; 130(20):4871-9. PMID: 12917290.
      View in: PubMed
    34. Chuang P, Kawcak T, McMahon AP. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003 Feb 1; 17(3):342-7. PMID: 12569124; PMCID: PMC195990.
    35. Chuang P, McMahon AP. Branching morphogenesis of the lung: new molecular insights into an old problem. Trends Cell Biol. 2003 Feb; 13(2):86-91. PMID: 12559759.
      View in: PubMed
    36. Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang P, Young SG, Skarnes WC, Babbitt PC, Ferrin TE. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1; 31(1):278-81. PMID: 12520002; PMCID: PMC165511.
    37. Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang P. Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec; 129(24):5753-65. PMID: 12421714.
      View in: PubMed
    38. Bonifas JM, Pennypacker S, Chuang P, McMahon AP, Williams M, Rosenthal A, De Sauvage FJ, Epstein EH. Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol. 2001 May; 116(5):739-42. PMID: 11348463.
      View in: PubMed
    39. Treier M, O'Connell S, Gleiberman A, Price J, Szeto DP, Burgess R, Chuang P, McMahon AP, Rosenfeld MG. Hedgehog signaling is required for pituitary gland development. Development. 2001 Feb; 128(3):377-86. PMID: 11152636.
      View in: PubMed
    40. Chuang P, Kornberg TB. On the range of hedgehog signaling. Curr Opin Genet Dev. 2000 Oct; 10(5):515-22. PMID: 10980429.
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    41. Chuang P, McMahon AP. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature. 1999 Feb 18; 397(6720):617-21. PMID: 10050855.
      View in: PubMed
    42. Arduengo PM, Appleberry OK, Chuang P, L'Hernault SW. The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis. J Cell Sci. 1998 Dec 18; 111 ( Pt 24):3645-54. PMID: 9819355.
      View in: PubMed
    43. Lieb JD, Albrecht MR, Chuang P, Meyer BJ. MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation. Cell. 1998 Jan 23; 92(2):265-77. PMID: 9458050.
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    44. Yang Y, Drossopoulou G, Chuang P, Duprez D, Marti E, Bumcrot D, Vargesson N, Clarke J, Niswander L, McMahon A, Tickle C. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development. 1997 Nov; 124(21):4393-404. PMID: 9334287.
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    45. McMahon AP, Chuang P. Hedgehogs in the clinic. Nat Med. 1996 Dec; 2(12):1308-10. PMID: 8946825.
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    46. Hsu DR, Chuang P, Meyer BJ. DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation. Development. 1995 Oct; 121(10):3323-34. PMID: 7588066.
      View in: PubMed
    47. Chuang P, Albertson DG, Meyer BJ. DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome. Cell. 1994 Nov 4; 79(3):459-74. PMID: 7954812.
      View in: PubMed
    48. Hariharan IK, Chuang P, Rubin GM. Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11266-70. PMID: 1662390; PMCID: PMC53115.
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