Pao-Tien Chuang, MD, PhD

InstitutionUniversity of California San Francisco
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular mechanisms of alveolar development and regeneration
    NIH/NHLBI R01HL142876Jul 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Sufu-interacting proteins provide novel insight into mammalian Hedgehog signaling
    NIH/NIGMS R01GM110487Jun 1, 2015 - May 31, 2019
    Role: Principal Investigator
    The lineage and function of neuroendocrine cells in lung homeostasis and injury
    NIH/NHLBI R01HL115207Jul 1, 2013 - Jun 30, 2017
    Role: Principal Investigator
    Epithelial Progenitor Cells in Lung Repair and Regeneration
    NIH/NHLBI U01HL111054Jan 1, 2012 - Dec 31, 2016
    Role: Co-Principal Investigator
    The molecular mechanisms by which mammalian Fused regulates motile cilia function
    NIH/NHLBI R01HL091915Dec 12, 2008 - Nov 30, 2013
    Role: Principal Investigator
    Molecular Mechanisms of Mammalian Hedgehog Signal Transduction
    NIH/NIGMS R01GM085097Aug 1, 2008 - Jul 31, 2013
    Role: Principal Investigator
    Control of Hedgehog protein gradient formation in vertebrates
    NIH/NHLBI R01HL067822Jul 1, 2001 - Mar 31, 2013
    Role: Principal Investigator
    Development and Control of Pulmonary alveolar Stability
    NIH P01HL024075Jul 1, 1979 - Dec 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yao E, Lin C, Wu Q, Zhang K, Song H, Chuang PT. Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury. Stem Cells. 2018 Mar; 36(3):377-391. PMID: 29148109.
      View in: PubMed
    2. Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson-Peer K, Chuang PT. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. Elife. 2017 03 21; 6. PMID: 28323616.
      View in: PubMed
    3. Song H, Lin C, Yao E, Zhang K, Li X, Wu Q, Chuang PT. Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma. J Biol Chem. 2017 03 03; 292(9):3888-3899. PMID: 28119454.
      View in: PubMed
    4. Lin C, Yao E, Chuang PT. A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 01; 403(1):101-13. PMID: 25912685; PMCID: PMC4469623.
    5. Yao E, Chuang PT. Hedgehog signaling: From basic research to clinical applications. J Formos Med Assoc. 2015 Jul; 114(7):569-76. PMID: 25701396.
      View in: PubMed
    6. Lin C, Yao E, Wang K, Nozawa Y, Shimizu H, Johnson JR, Chen JN, Krogan NJ, Chuang PT. Regulation of Sufu activity by p66ß and Mycbp provides new insight into vertebrate Hedgehog signaling. Genes Dev. 2014 Nov 15; 28(22):2547-63. PMID: 25403183; PMCID: PMC4233246.
    7. Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, Chuang PT. Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Dev Biol. 2014 Aug 15; 392(2):324-33. PMID: 24886827; PMCID: PMC4106470.
    8. Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC. A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28; 29(2):241-9. PMID: 24726283.
      View in: PubMed
    9. Nozawa YI, Yao E, Gacayan R, Xu SM, Chuang PT. Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis. Dev Biol. 2014 Apr 15; 388(2):170-80. PMID: 24525297; PMCID: PMC3982599.
    10. Nozawa YI, Yao E, Lin C, Yang JH, Wilson CW, Gacayan R, Chuang PT. Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct. Dev Dyn. 2013 Nov; 242(11):1307-19. PMID: 23907739.
      View in: PubMed
    11. Nozawa YI, Lin C, Chuang PT. Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction. Curr Opin Genet Dev. 2013 Aug; 23(4):429-37. PMID: 23725801; PMCID: PMC3913210.
    12. Lin C, Song H, Huang C, Yao E, Gacayan R, Xu SM, Chuang PT. Alveolar type II cells possess the capability of initiating lung tumor development. PLoS One. 2012; 7(12):e53817. PMID: 23285300; PMCID: PMC3527621.
    13. Song H, Yao E, Lin C, Gacayan R, Chen MH, Chuang PT. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17531-6. PMID: 23047698; PMCID: PMC3491514.
    14. Lin C, Nozawa YI, Chuang PT. The path to chemotaxis and transcription is smoothened. Sci Signal. 2012 Aug 21; 5(238):pe35. PMID: 22912492.
      View in: PubMed
    15. Engel BD, Ishikawa H, Feldman JL, Wilson CW, Chuang PT, Snedecor J, Williams J, Sun Z, Marshall WF. A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow. Cytoskeleton (Hoboken). 2011 Mar; 68(3):188-203. PMID: 21360831.
      View in: PubMed
    16. Wilson CW, Chuang PT. Mechanism and evolution of cytosolic Hedgehog signal transduction. Development. 2010 Jul; 137(13):2079-94. PMID: 20530542; PMCID: PMC2882129.
    17. Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009 Aug 15; 23(16):1910-28. PMID: 19684112; PMCID: PMC2725943.
    18. Wilson CW, Chen MH, Chuang PT. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One. 2009; 4(4):e5182. PMID: 19365551; PMCID: PMC2664476.
    19. Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang PT. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature. 2009 May 07; 459(7243):98-102. PMID: 19305393; PMCID: PMC3204898.
    20. Mak KK, Bi Y, Wan C, Chuang PT, Clemens T, Young M, Yang Y. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev Cell. 2008 May; 14(5):674-88. PMID: 18477451.
      View in: PubMed
    21. Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y. Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development. 2008 Jun; 135(11):1947-56. PMID: 18434416.
      View in: PubMed
    22. Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen MH, Chuang PT, Reiter JF. Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol. 2008 Jan; 10(1):70-6. PMID: 18084282.
      View in: PubMed
    23. Chen MH, Wilson CW, Chuang PT. SnapShot: hedgehog signaling pathway. Cell. 2007 Jul 27; 130(2):386. PMID: 17662951.
      View in: PubMed
    24. Mak KK, Chen MH, Day TF, Chuang PT, Yang Y. Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development. 2006 Sep; 133(18):3695-707. PMID: 16936073.
      View in: PubMed
    25. Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M. Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened. Dev Biol. 2006 Sep 01; 297(1):127-40. PMID: 16765934.
      View in: PubMed
    26. Wilson CW, Chuang PT. New "hogs" in Hedgehog transport and signal reception. Cell. 2006 May 05; 125(3):435-8. PMID: 16678090.
      View in: PubMed
    27. Hu MC, Mo R, Bhella S, Wilson CW, Chuang PT, Hui CC, Rosenblum ND. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development. 2006 Feb; 133(3):569-78. PMID: 16396903.
      View in: PubMed
    28. Chen MH, Gao N, Kawakami T, Chuang PT. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol Cell Biol. 2005 Aug; 25(16):7042-53. PMID: 16055716; PMCID: PMC1190231.
    29. Yang SH, Shrivastav A, Kosinski C, Sharma RK, Chen MH, Berthiaume LG, Peters LL, Chuang PT, Young SG, Bergo MO. N-myristoyltransferase 1 is essential in early mouse development. J Biol Chem. 2005 May 13; 280(19):18990-5. PMID: 15753093.
      View in: PubMed
    30. Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15; 18(6):641-59. PMID: 15075292; PMCID: PMC387240.
    31. Vogt A, Chuang PT, Hebert J, Hwang J, Lu Y, Kopelovich L, Athar M, Bickers DR, Epstein EH. Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. J Exp Med. 2004 Mar 15; 199(6):753-61. PMID: 15024045; PMCID: PMC2212732.
    32. Wang JY, Chuang PY, Lin CJ, Yu CJ, Yang PC. Continuous lateral rotational therapy in the medical intensive care unit. J Formos Med Assoc. 2003 Nov; 102(11):788-92. PMID: 14724725.
      View in: PubMed
    33. Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M. Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development. 2003 Oct; 130(20):4871-9. PMID: 12917290.
      View in: PubMed
    34. Chuang PT, McMahon AP. Branching morphogenesis of the lung: new molecular insights into an old problem. Trends Cell Biol. 2003 Feb; 13(2):86-91. PMID: 12559759.
      View in: PubMed
    35. Chuang PT, Kawcak T, McMahon AP. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003 Feb 01; 17(3):342-7. PMID: 12569124; PMCID: PMC195990.
    36. Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 01; 31(1):278-81. PMID: 12520002; PMCID: PMC165511.
    37. Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT. Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec; 129(24):5753-65. PMID: 12421714.
      View in: PubMed