Pao-Tien Chuang, MD, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #252F
San Francisco CA 94158
Phone415-514-0667
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular mechanisms of alveolar development and regeneration
    NIH R01HL142876Jul 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Sufu-interacting proteins provide novel insight into mammalian Hedgehog signaling
    NIH R01GM110487Jun 1, 2015 - May 31, 2019
    Role: Principal Investigator
    The lineage and function of neuroendocrine cells in lung homeostasis and injury
    NIH R01HL115207Jul 1, 2013 - Jun 30, 2017
    Role: Principal Investigator
    Epithelial Progenitor Cells in Lung Repair and Regeneration
    NIH U01HL111054Jan 1, 2012 - Dec 31, 2016
    Role: Co-Principal Investigator
    The molecular mechanisms by which mammalian Fused regulates motile cilia function
    NIH R01HL091915Dec 12, 2008 - Nov 30, 2014
    Role: Principal Investigator
    Molecular Mechanisms of Mammalian Hedgehog Signal Transduction
    NIH R01GM085097Aug 1, 2008 - Jul 31, 2013
    Role: Principal Investigator
    Control of Hedgehog protein gradient formation in vertebrates
    NIH R01HL067822Jul 1, 2001 - Mar 31, 2013
    Role: Principal Investigator
    Development and Control of Pulmonary alveolar Stability
    NIH P01HL024075Jul 1, 1979 - Dec 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The alveolus: Our current knowledge of how the gas exchange unit of the lung is constructed and repaired. Curr Top Dev Biol. 2024; 159:59-129. Zhang K, Yao E, Aung T, Chuang PT. PMID: 38729684.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    2. Lung patterning: Is a distal-to-proximal gradient of cell allocation and fate decision a general paradigm?: A gradient of distal-to-proximal distribution and differentiation of tip progenitors produces distinct compartments in the lung. Bioessays. 2024 01; 46(1):e2300083. Zhang K, Aung T, Yao E, Chuang PT. PMID: 38010492.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Monitoring the performance of a dedicated weaning unit using risk-adjusted control charts for the weaning rate in prolonged mechanical ventilation. J Formos Med Assoc. 2023 Sep; 122(9):880-889. Huang HF, Jerng JS, Hsu PJ, Lin NH, Lin LM, Hung SM, Kuo YW, Ku SC, Chuang PY, Chen SY. PMID: 37149422.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity. Nat Commun. 2022 11 25; 13(1):7252. Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Chuang PT. PMID: 36433959; PMCID: PMC9700781.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions. PLoS Biol. 2022 08; 20(8):e3001759. Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT. PMID: 36026468; PMCID: PMC9469998.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange. Dev Cell. 2022 07 11; 57(13):1566-1581.e7. Zhang K, Yao E, Wang SA, Chuang E, Wong J, Minichiello L, Schroeder A, Eckalbar W, Wolters PJ, Chuang PT. PMID: 35714603; PMCID: PMC9308505.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria. Elife. 2022 04 06; 11. Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT. PMID: 35384838; PMCID: PMC9183236.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    8. A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. Elife. 2020 05 12; 9. Zhang K, Yao E, Lin C, Chou YT, Wong J, Li J, Wolters PJ, Chuang PT. PMID: 32394892; PMCID: PMC7217702.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    9. Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury. Stem Cells. 2018 03; 36(3):377-391. Yao E, Lin C, Wu Q, Zhang K, Song H, Chuang PT. PMID: 29148109.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    10. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. Elife. 2017 03 21; 6. Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson-Peer K, Chuang PT. PMID: 28323616; PMCID: PMC5360446.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    11. Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma. J Biol Chem. 2017 03 03; 292(9):3888-3899. Song H, Lin C, Yao E, Zhang K, Li X, Wu Q, Chuang PT. PMID: 28119454; PMCID: PMC5339769.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 01; 403(1):101-13. Lin C, Yao E, Chuang PT. PMID: 25912685; PMCID: PMC4469623.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    13. Hedgehog signaling: From basic research to clinical applications. J Formos Med Assoc. 2015 Jul; 114(7):569-76. Yao E, Chuang PT. PMID: 25701396.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    14. Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling. Genes Dev. 2014 Nov 15; 28(22):2547-63. Lin C, Yao E, Wang K, Nozawa Y, Shimizu H, Johnson JR, Chen JN, Krogan NJ, Chuang PT. PMID: 25403183; PMCID: PMC4233246.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    15. Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Dev Biol. 2014 Aug 15; 392(2):324-33. Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, Chuang PT. PMID: 24886827; PMCID: PMC4106470.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    16. A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28; 29(2):241-9. Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC. PMID: 24726283.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    17. Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis. Dev Biol. 2014 Apr 15; 388(2):170-80. Nozawa YI, Yao E, Gacayan R, Xu SM, Chuang PT. PMID: 24525297; PMCID: PMC3982599.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    18. Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct. Dev Dyn. 2013 Nov; 242(11):1307-19. Nozawa YI, Yao E, Lin C, Yang JH, Wilson CW, Gacayan R, Chuang PT. PMID: 23907739.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    19. Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction. Curr Opin Genet Dev. 2013 Aug; 23(4):429-37. Nozawa YI, Lin C, Chuang PT. PMID: 23725801; PMCID: PMC3913210.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    20. Alveolar type II cells possess the capability of initiating lung tumor development. PLoS One. 2012; 7(12):e53817. Lin C, Song H, Huang C, Yao E, Gacayan R, Xu SM, Chuang PT. PMID: 23285300; PMCID: PMC3527621.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    21. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17531-6. Song H, Yao E, Lin C, Gacayan R, Chen MH, Chuang PT. PMID: 23047698; PMCID: PMC3491514.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimalsCells
    22. The path to chemotaxis and transcription is smoothened. Sci Signal. 2012 Aug 21; 5(238):pe35. Lin C, Nozawa YI, Chuang PT. PMID: 22912492.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow. Cytoskeleton (Hoboken). 2011 Mar; 68(3):188-203. Engel BD, Ishikawa H, Feldman JL, Wilson CW, Chuang PT, Snedecor J, Williams J, Sun Z, Marshall WF. PMID: 21360831.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    24. Mechanism and evolution of cytosolic Hedgehog signal transduction. Development. 2010 Jul; 137(13):2079-94. Wilson CW, Chuang PT. PMID: 20530542; PMCID: PMC2882129.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    25. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009 Aug 15; 23(16):1910-28. Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT. PMID: 19684112; PMCID: PMC2725943.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    26. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One. 2009; 4(4):e5182. Wilson CW, Chen MH, Chuang PT. PMID: 19365551; PMCID: PMC2664476.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    27. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature. 2009 May 07; 459(7243):98-102. Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang PT. PMID: 19305393; PMCID: PMC3204898.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    28. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev Cell. 2008 May; 14(5):674-88. Mak KK, Bi Y, Wan C, Chuang PT, Clemens T, Young M, Yang Y. PMID: 18477451.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    29. Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development. 2008 Jun; 135(11):1947-56. Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y. PMID: 18434416; PMCID: PMC7188307.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    30. Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol. 2008 Jan; 10(1):70-6. Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen MH, Chuang PT, Reiter JF. PMID: 18084282.
      View in: PubMed   Mentions: 293     Fields:    Translation:AnimalsCells
    31. SnapShot: hedgehog signaling pathway. Cell. 2007 Jul 27; 130(2):386. Chen MH, Wilson CW, Chuang PT. PMID: 17662951.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    32. The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation. Oncogene. 2007 Feb 22; 26(8):1122-36. Gerber AN, Wilson CW, Li YJ, Chuang PT. PMID: 16964293; PMCID: PMC3325095.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    33. Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development. 2006 Sep; 133(18):3695-707. Mak KK, Chen MH, Day TF, Chuang PT, Yang Y. PMID: 16936073.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    34. Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened. Dev Biol. 2006 Sep 01; 297(1):127-40. Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M. PMID: 16765934.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    35. New "hogs" in Hedgehog transport and signal reception. Cell. 2006 May 05; 125(3):435-8. Wilson CW, Chuang PT. PMID: 16678090.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    36. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development. 2006 Feb; 133(3):569-78. Hu MC, Mo R, Bhella S, Wilson CW, Chuang PT, Hui CC, Rosenblum ND. PMID: 16396903.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    37. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol Cell Biol. 2005 Aug; 25(16):7042-53. Chen MH, Gao N, Kawakami T, Chuang PT. PMID: 16055716; PMCID: PMC1190231.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    38. N-myristoyltransferase 1 is essential in early mouse development. J Biol Chem. 2005 May 13; 280(19):18990-5. Yang SH, Shrivastav A, Kosinski C, Sharma RK, Chen MH, Berthiaume LG, Peters LL, Chuang PT, Young SG, Bergo MO. PMID: 15753093.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    39. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15; 18(6):641-59. Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT. PMID: 15075292; PMCID: PMC387240.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    40. Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. J Exp Med. 2004 Mar 15; 199(6):753-61. Vogt A, Chuang PT, Hebert J, Hwang J, Lu Y, Kopelovich L, Athar M, Bickers DR, Epstein EH. PMID: 15024045; PMCID: PMC2212732.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    41. Continuous lateral rotational therapy in the medical intensive care unit. J Formos Med Assoc. 2003 Nov; 102(11):788-92. Wang JY, Chuang PY, Lin CJ, Yu CJ, Yang PC. PMID: 14724725.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    42. Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development. 2003 Oct; 130(20):4871-9. Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M. PMID: 12917290.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    43. Branching morphogenesis of the lung: new molecular insights into an old problem. Trends Cell Biol. 2003 Feb; 13(2):86-91. Chuang PT, McMahon AP. PMID: 12559759.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    44. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003 Feb 01; 17(3):342-7. Chuang PT, Kawcak T, McMahon AP. PMID: 12569124; PMCID: PMC195990.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    45. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 01; 31(1):278-81. Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE. PMID: 12520002; PMCID: PMC165511.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    46. Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec; 129(24):5753-65. Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT. PMID: 12421714.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    47. Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol. 2001 May; 116(5):739-42. Bonifas JM, Pennypacker S, Chuang PT, McMahon AP, Williams M, Rosenthal A, De Sauvage FJ, Epstein EH. PMID: 11348463.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    48. Hedgehog signaling is required for pituitary gland development. Development. 2001 Feb; 128(3):377-86. Treier M, O'Connell S, Gleiberman A, Price J, Szeto DP, Burgess R, Chuang PT, McMahon AP, Rosenfeld MG. PMID: 11152636.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    49. On the range of hedgehog signaling. Curr Opin Genet Dev. 2000 Oct; 10(5):515-22. Chuang PT, Kornberg TB. PMID: 10980429.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    50. Determination of the chromosomal location and genomic structure of theHedgehog-Interacting Protein gene, and analysis of its role in Holoprosencephaly. International Journal of Genomics. 2000 Oct 1; 1(3-4):1-9. Huo HL, Roessler RE, Dutra DA, Chuang CP, McMahon MA, Muenke MM. .
      View in: Publisher Site   Mentions:
    51. Determination of the chromosomal location and genomic structure of the Hedgehog-Interacting Protein gene, and analysis of its role in Holoprosencephaly. International Journal of Genomics. 2000 Oct 1; 1(3-4):119-127. Huo HL, Roessler RE, Dutra DA, Chuang CP, McMahon MA, Muenke MM. .
      View in: Publisher Site   Mentions:
    52. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature. 1999 Feb 18; 397(6720):617-21. Chuang PT, McMahon AP. PMID: 10050855.
      View in: PubMed   Mentions: 281     Fields:    Translation:AnimalsCells
    53. MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation. Cell. 1998 Jan 23; 92(2):265-77. Lieb JD, Albrecht MR, Chuang PT, Meyer BJ. PMID: 9458050.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    54. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development. 1997 Nov; 124(21):4393-404. Yang Y, Drossopoulou G, Chuang PT, Duprez D, Marti E, Bumcrot D, Vargesson N, Clarke J, Niswander L, McMahon A, Tickle C. PMID: 9334287.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    55. Hedgehogs in the clinic. Nat Med. 1996 Dec; 2(12):1308-10. McMahon AP, Chuang PT. PMID: 8946825.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    56. DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation. Development. 1995 Oct; 121(10):3323-34. Hsu DR, Chuang PT, Meyer BJ. PMID: 7588066.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    57. DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome. Cell. 1994 Nov 04; 79(3):459-74. Chuang PT, Albertson DG, Meyer BJ. PMID: 7954812.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
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