Paola Bisignano, PhD

Title(s)Postdoctoral Scholar, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    1. CSIG-22. CANCER-ASSOCIATED MISSENSE SINGLE NUCLEOTIDE VARIANTS REGULATE THE STABILITY AND SUBCELLULAR LOCALIZATION OF NF2/MERLIN. Neuro-Oncology. 2020 Nov 9; 22(Supplement_2):ii32-ii32. Charlotte Eaton, Paola Bisignano, David Raleigh. .
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    2. A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms. PLoS Comput Biol. 2020 07; 16(7):e1007884. George A, Bisignano P, Rosenberg JM, Grabe M, Zuckerman DM. PMID: 32614821.
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    3. A kinetic mechanism for enhanced selectivity of membrane transport. PLoS Comput Biol. 2020 07; 16(7):e1007789. Bisignano P, Lee MA, George A, Zuckerman DM, Grabe M, Rosenberg JM. PMID: 32614861.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Quantitative Simulations of Alternating Access in Sodium-Solute Symporters. Biophysical Journal. 2019 Feb 1; 116(3):554a. Paola Bisignano, Sara Capponi, John M. Rosenberg, Michael Grabe. .
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    5. A Triazolotriazine-Based Dual GSK-3ß/CK-1d Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. ChemMedChem. 2019 02 05; 14(3):310-314. Redenti S, Marcovich I, De Vita T, Pérez C, De Zorzi R, Demitri N, Perez DI, Bottegoni G, Bisignano P, Bissaro M, Moro S, Martinez A, Storici P, Spalluto G, Cavalli A, Federico S. PMID: 30548443.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    7. Cilia-Associated Oxysterols Activate Smoothened. Mol Cell. 2018 10 18; 72(2):316-327.e5. Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. PMID: 30340023.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    8. Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site. Nat Commun. 2018 05 01; 9(1):1753. Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R. PMID: 29717135.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    9. Conformational transitions of the sodium-dependent sugar transporter, vSGLT. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2742-E2751. Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. PMID: 29507231.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    10. Conformational Landscape of Sodium Glucose Transporters. Biophysical Journal. 2018 Feb 1; 114(3):558a. Paola Bisignano, Sara Capponi, John M. Rosenberg, Michael Grabe. .
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    11. Protonation State of Glutamate 73 Regulates the Formation of a Unique Dimeric Association of VDAC1. Biophysical Journal. 2018 Feb 1; 114(3):378a. Lucie A. Bergdoll, Michael T. Lerch, John W. Patrick, Christian Altenbach, Paola Bisignano, Arthur Laganowsky, Michael Grabe, Wayne Hubbell, Jeff Abramson. .
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    12. Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E172-E179. Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J. PMID: 29279396.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    13. Structural Insights into Sodium-Dependent Sugar Transporters and their Inhibition Mechanism. Biophysical Journal. 2017 Feb 1; 112(3):128a. Paola Bisignano, Chakrapani Kalyanaraman, Chiara Ghezzi, Ernest M. Wright, Jeff Abramson, Aviv Paz, Matthew P. Jacobson, Rosmarie Friemann, Michael Grabe. .
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    14. Ph-Induced Oligomerization of the Voltage Dependent Anion Channel. Biophysical Journal. 2017 Feb 1; 112(3):184a. Lucie A. Bergdoll, Michael T. Lerch, Kendrick Belardo, Christian Altenbach, Paola Bisignano, Michael Grabe, Wayne Hubbell, Jeff Abramson. .
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    15. Inhibiting SOX11-DNA Interaction in Mantle Cell Lymphoma. Blood. 2016 Dec 2; 128(22):1840-1840. Stephanie Christie, Shashidhar Jatiani, Pei-Yu Kuo, Violetta Leshchenko, Abhijeet Kapoor, Paola Bisignano, Aneel Aggarwal, Marta Filizola, Samir Parekh. .
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    16. Inside Cover: Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments (ChemMedChem 12/2016). ChemMedChem. 2016 Jun 20; 11(12):1189-1189. Giovanni Bottegoni, Marina Veronesi, Paola Bisignano, Puneet Kacker, Angelo D. Favia, Andrea Cavalli. .
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    17. Stochastic steps in secondary active sugar transport. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3960-6. Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. PMID: 27325773.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    18. Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal. 2016 05 31; 9(430):ra55. Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, Gupta A, Mezei M, Kumar S, Filizola M, Devi LA. PMID: 27245612.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. Structure-Based Drug Design for Sodium-Dependent Glucose Transporters. Biophysical Journal. 2016 Feb 1; 110(3):136a. Paola Bisignano, Chakrapani Kalyanaraman, Ernest Wright, Jeff Abramson, Matthew Jacobson, Michael Grabe. .
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    20. Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3ß Inhibitors. J Med Chem. 2016 Jan 28; 59(2):531-44. Di Martino RM, De Simone A, Andrisano V, Bisignano P, Bisi A, Gobbi S, Rampa A, Fato R, Bergamini C, Perez DI, Martinez A, Bottegoni G, Cavalli A, Belluti F. PMID: 26696252.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    21. Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments. ChemMedChem. 2016 Jun 20; 11(12):1259-63. Bottegoni G, Veronesi M, Bisignano P, Kacker P, Favia AD, Cavalli A. PMID: 26663255.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    22. Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the µ-Opioid Receptor. J Chem Inf Model. 2015 Sep 28; 55(9):1836-43. Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M. PMID: 26347990.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    23. Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3ß Inhibitors. Angewandte Chemie. 2015 Jan 26; 127(5):1598-1602. Federica Prati, Angela De Simone, Paola Bisignano, Andrea Armirotti, Maria Summa, Daniela Pizzirani, Rita Scarpelli, Daniel I. Perez, Vincenza Andrisano, Ana Perez-Castillo, Barbara Monti, Francesca Massenzio, Letizia Polito, Marco Racchi, Angelo D. Favia, Giovanni Bottegoni, Ana Martinez, Maria Laura Bolognesi, Andrea Cavalli. .
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    24. Binding Pockets and Poses of Allosteric Modulators of Opioid Receptors Identified by Metadynamics. Biophysical Journal. 2015 Jan 1; 108(2):415a. Yi Shang, Holly R. Yeatman, Neil Burford, Kathryn Livingston, Paola Bisignano, John Traynor, Andrew Alt, Arthur Christopoulos, Meritxell Canals, Marta Filizola. .
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    25. Structure-Guided Discovery of Positive Allosteric Modulators of the Mu-Opioid Receptor. Biophysical Journal. 2015 Jan 1; 108(2):414a-415a. Paola Bisignano, Neil T. Burford, Samuel W. Gerritz, Andrew Alt, Marta Filizola. .
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    26. Biased Agonism at Opioid Receptors: Insights from Analysis of Structural Interaction Fingerprints. Biophysical Journal. 2015 Jan 1; 108(2):350a. Davide Provasi, Paola Bisignano, Marta Filizola. .
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    27. Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3ß inhibitors. Angew Chem Int Ed Engl. 2015 Jan 26; 54(5):1578-82. Prati F, De Simone A, Bisignano P, Armirotti A, Summa M, Pizzirani D, Scarpelli R, Perez DI, Andrisano V, Perez-Castillo A, Monti B, Massenzio F, Polito L, Racchi M, Favia AD, Bottegoni G, Martinez A, Bolognesi ML, Cavalli A. PMID: 25504761.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    28. Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions. Biochemistry. 2014 Aug 12; 53(31):5140-9. Shang Y, LeRouzic V, Schneider S, Bisignano P, Pasternak GW, Filizola M. PMID: 25073009.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    29. Kinetic characterization of fragment binding in AmpC ß-lactamase by high-throughput molecular simulations. J Chem Inf Model. 2014 Feb 24; 54(2):362-6. Bisignano P, Doerr S, Harvey MJ, Favia AD, Cavalli A, De Fabritiis G. PMID: 24444037.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    30. In silico deconstruction of ATP-competitive inhibitors of glycogen synthase kinase-3ß. J Chem Inf Model. 2012 Dec 21; 52(12):3233-44. Bisignano P, Lambruschini C, Bicego M, Murino V, Favia AD, Cavalli A. PMID: 23198830.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    31. PLI: a web-based tool for the comparison of protein-ligand interactions observed on PDB structures. Bioinformatics. 2013 Feb 01; 29(3):395-7. Gallina AM, Bisignano P, Bergamino M, Bordo D. PMID: 23196990.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    32. SERAPhiC: a benchmark for in silico fragment-based drug design. J Chem Inf Model. 2011 Nov 28; 51(11):2882-96. Favia AD, Bottegoni G, Nobeli I, Bisignano P, Cavalli A. PMID: 21936510.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    33. An innovative protocol for comparing protein binding site via atomic grid maps. KDIR. 2011; 413-422. Bicego M., Favia A. D., Bisignano, P, Cavalli, A., and Murino, V.
    34. Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR-nucleotide binding domain 1. Biochimie. 2010 Jan; 92(1):51-7. Bisignano P, Moran O. PMID: 19781595.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
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