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Paola Bisignano, PhD

TitlePostdoctoral Scholar
InstitutionUniversity of California San Francisco
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R. Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site. Nat Commun. 2018 May 01; 9(1):1753. PMID: 29717135.
      View in: PubMed
    2. Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. Conformational transitions of the sodium-dependent sugar transporter, vSGLT. Proc Natl Acad Sci U S A. 2018 Mar 20; 115(12):E2742-E2751. PMID: 29507231.
      View in: PubMed
    3. Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J. Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Proc Natl Acad Sci U S A. 2018 Jan 09; 115(2):E172-E179. PMID: 29279396.
      View in: PubMed
    4. Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. Stochastic steps in secondary active sugar transport. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3960-6. PMID: 27325773; PMCID: PMC4941443 [Available on 01/05/17].
    5. Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, Gupta A, Mezei M, Kumar S, Filizola M, Devi LA. Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal. 2016 05 31; 9(430):ra55. PMID: 27245612.
      View in: PubMed
    6. Di Martino RM, De Simone A, Andrisano V, Bisignano P, Bisi A, Gobbi S, Rampa A, Fato R, Bergamini C, Perez DI, Martinez A, Bottegoni G, Cavalli A, Belluti F. Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3ß Inhibitors. J Med Chem. 2016 Jan 28; 59(2):531-44. PMID: 26696252.
      View in: PubMed
    7. Bottegoni G, Veronesi M, Bisignano P, Kacker P, Favia AD, Cavalli A. Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments. ChemMedChem. 2016 Jun 20; 11(12):1259-63. PMID: 26663255.
      View in: PubMed
    8. Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M. Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the µ-Opioid Receptor. J Chem Inf Model. 2015 Sep 28; 55(9):1836-43. PMID: 26347990; PMCID: PMC4703110.
    9. Prati F, De Simone A, Bisignano P, Armirotti A, Summa M, Pizzirani D, Scarpelli R, Perez DI, Andrisano V, Perez-Castillo A, Monti B, Massenzio F, Polito L, Racchi M, Favia AD, Bottegoni G, Martinez A, Bolognesi ML, Cavalli A. Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3ß inhibitors. Angew Chem Int Ed Engl. 2015 Jan 26; 54(5):1578-82. PMID: 25504761.
      View in: PubMed
    10. Shang Y, LeRouzic V, Schneider S, Bisignano P, Pasternak GW, Filizola M. Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions. Biochemistry. 2014 Aug 12; 53(31):5140-9. PMID: 25073009; PMCID: PMC4131901.
    11. Bisignano P, Doerr S, Harvey MJ, Favia AD, Cavalli A, De Fabritiis G. Kinetic characterization of fragment binding in AmpC ß-lactamase by high-throughput molecular simulations. J Chem Inf Model. 2014 Feb 24; 54(2):362-6. PMID: 24444037.
      View in: PubMed
    12. Bisignano P, Lambruschini C, Bicego M, Murino V, Favia AD, Cavalli A. In silico deconstruction of ATP-competitive inhibitors of glycogen synthase kinase-3ß. J Chem Inf Model. 2012 Dec 21; 52(12):3233-44. PMID: 23198830.
      View in: PubMed
    13. Gallina AM, Bisignano P, Bergamino M, Bordo D. PLI: a web-based tool for the comparison of protein-ligand interactions observed on PDB structures. Bioinformatics. 2013 Feb 01; 29(3):395-7. PMID: 23196990.
      View in: PubMed
    14. Favia AD, Bottegoni G, Nobeli I, Bisignano P, Cavalli A. SERAPhiC: a benchmark for in silico fragment-based drug design. J Chem Inf Model. 2011 Nov 28; 51(11):2882-96. PMID: 21936510.
      View in: PubMed
    15. Bisignano P, Moran O. Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR-nucleotide binding domain 1. Biochimie. 2010 Jan; 92(1):51-7. PMID: 19781595.
      View in: PubMed
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