Paola Bisignano, PhD

Title(s)Volunteer, Cardiovascular Research Inst
SchoolSchool of Medicine
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    1. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2022 Sep 1; 1863:148719. Bertholet BA, Natale NA, Bisignano BP, Suzuki SJ, Fedorenko FA, Hamilton HJ, Brustovetsky BT, Kazak KL, Garrity GR, Chouchani CE, Brustovetsky BN, Grabe GM, Kirichok KY. .
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    2. Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice. Nat Biotechnol. 2022 Jul 25. Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS. PMID: 35879364.
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    3. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Nature. 2022 06; 606(7912):180-187. Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. PMID: 35614225; PMCID: PMC9646675.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Biophysical Journal. 2022 Feb 1; 121(3):513a. Grabe GM, Natale NA, Bertholet BA, Bisignano BP, Kirichok KY, Suzuki SJ. .
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    5. SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma. Clin Cancer Res. 2021 08 15; 27(16):4652-4663. Jatiani SS, Christie S, Leshchenko VV, Jain R, Kapoor A, Bisignano P, Lee C, Kaniskan HÜ, Edwards D, Meng F, Laganà A, Youssef Y, Wiestner A, Alinari L, Jin J, Filizola M, Aggarwal AK, Parekh S. PMID: 34158358; PMCID: PMC8364871.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
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    7. A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms. PLoS Comput Biol. 2020 07; 16(7):e1007884. George A, Bisignano P, Rosenberg JM, Grabe M, Zuckerman DM. PMID: 32614821; PMCID: PMC7331975.
      View in: PubMed   Mentions: 3     Fields:    
    8. A kinetic mechanism for enhanced selectivity of membrane transport. PLoS Comput Biol. 2020 07; 16(7):e1007789. Bisignano P, Lee MA, George A, Zuckerman DM, Grabe M, Rosenberg JM. PMID: 32614861; PMCID: PMC7331977.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Quantitative Simulations of Alternating Access in Sodium-Solute Symporters. Biophysical Journal. 2019 Feb 1; 116(3):554a. Bisignano BP, Capponi CS, Rosenberg RJ, Grabe GM. .
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    10. A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. ChemMedChem. 2019 02 05; 14(3):310-314. Redenti S, Marcovich I, De Vita T, Pérez C, De Zorzi R, Demitri N, Perez DI, Bottegoni G, Bisignano P, Bissaro M, Moro S, Martinez A, Storici P, Spalluto G, Cavalli A, Federico S. PMID: 30548443.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032; PMCID: PMC6286348.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    12. Cilia-Associated Oxysterols Activate Smoothened. Mol Cell. 2018 10 18; 72(2):316-327.e5. Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. PMID: 30340023; PMCID: PMC6503851.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    13. Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site. Nat Commun. 2018 05 01; 9(1):1753. Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R. PMID: 29717135; PMCID: PMC5931594.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    14. Conformational transitions of the sodium-dependent sugar transporter, vSGLT. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2742-E2751. Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. PMID: 29507231; PMCID: PMC5866573.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    15. Conformational Landscape of Sodium Glucose Transporters. Biophysical Journal. 2018 Feb 1; 114(3):558a. Bisignano BP, Capponi CS, Rosenberg RJ, Grabe GM. .
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    16. Protonation State of Glutamate 73 Regulates the Formation of a Unique Dimeric Association of VDAC1. Biophysical Journal. 2018 Feb 1; 114(3):378a. Bergdoll BL, Lerch LM, Patrick PJ, Altenbach AC, Bisignano BP, Laganowsky LA, Grabe GM, Hubbell HW, Abramson AJ. .
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    17. Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E172-E179. Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J. PMID: 29279396; PMCID: PMC5777057.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    18. Structural Insights into Sodium-Dependent Sugar Transporters and their Inhibition Mechanism. Biophysical Journal. 2017 Feb 1; 112(3):128a. Bisignano BP, Kalyanaraman KC, Ghezzi GC, Wright WE, Abramson AJ, Paz PA, Jacobson JM, Friemann FR, Grabe GM. .
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    19. Ph-Induced Oligomerization of the Voltage Dependent Anion Channel. Biophysical Journal. 2017 Feb 1; 112(3):184a. Bergdoll BL, Lerch LM, Belardo BK, Altenbach AC, Bisignano BP, Grabe GM, Hubbell HW, Abramson AJ. .
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    20. Inhibiting SOX11-DNA Interaction in Mantle Cell Lymphoma. Blood. 2016 Dec 2; 128(22):1840-1840. Christie CS, Jatiani JS, Kuo KP, Leshchenko LV, Kapoor KA, Bisignano BP, Aggarwal AA, Filizola FM, Parekh PS. .
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    21. Inside Cover: Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments (ChemMedChem 12/2016). ChemMedChem. 2016 Jun 20; 11(12):1189-1189. Bottegoni BG, Veronesi VM, Bisignano BP, Kacker KP, Favia FA, Cavalli CA. .
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    22. Stochastic steps in secondary active sugar transport. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3960-6. Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. PMID: 27325773; PMCID: PMC4941443.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    23. Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal. 2016 05 31; 9(430):ra55. Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, Gupta A, Mezei M, Kumar S, Filizola M, Devi LA. PMID: 27245612; PMCID: PMC5150984.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    24. Structure-Based Drug Design for Sodium-Dependent Glucose Transporters. Biophysical Journal. 2016 Feb 1; 110(3):136a. Bisignano BP, Kalyanaraman KC, Wright WE, Abramson AJ, Jacobson JM, Grabe GM. .
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    25. Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors. J Med Chem. 2016 Jan 28; 59(2):531-44. Di Martino RM, De Simone A, Andrisano V, Bisignano P, Bisi A, Gobbi S, Rampa A, Fato R, Bergamini C, Perez DI, Martinez A, Bottegoni G, Cavalli A, Belluti F. PMID: 26696252.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    26. Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments. ChemMedChem. 2016 Jun 20; 11(12):1259-63. Bottegoni G, Veronesi M, Bisignano P, Kacker P, Favia AD, Cavalli A. PMID: 26663255.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    27. Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor. J Chem Inf Model. 2015 Sep 28; 55(9):1836-43. Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M. PMID: 26347990; PMCID: PMC4703110.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    28. Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3ß Inhibitors. Angewandte Chemie. 2015 Jan 26; 127(5):1598-1602. Prati PF, De Simone DA, Bisignano BP, Armirotti AA, Summa SM, Pizzirani PD, Scarpelli SR, Perez PD, Andrisano AV, Perez-Castillo PA, Monti MB, Massenzio MF, Polito PL, Racchi RM, Favia FA, Bottegoni BG, Martinez MA, Bolognesi BM, Cavalli CA. .
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    29. Binding Pockets and Poses of Allosteric Modulators of Opioid Receptors Identified by Metadynamics. Biophysical Journal. 2015 Jan 1; 108(2):415a. Shang SY, Yeatman YH, Burford BN, Livingston LK, Bisignano BP, Traynor TJ, Alt AA, Christopoulos CA, Canals CM, Filizola FM. .
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    30. Structure-Guided Discovery of Positive Allosteric Modulators of the Mu-Opioid Receptor. Biophysical Journal. 2015 Jan 1; 108(2):414a-415a. Bisignano BP, Burford BN, Gerritz GS, Alt AA, Filizola FM. .
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    31. Biased Agonism at Opioid Receptors: Insights from Analysis of Structural Interaction Fingerprints. Biophysical Journal. 2015 Jan 1; 108(2):350a. Provasi PD, Bisignano BP, Filizola FM. .
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    32. Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors. Angew Chem Int Ed Engl. 2015 Jan 26; 54(5):1578-82. Prati F, De Simone A, Bisignano P, Armirotti A, Summa M, Pizzirani D, Scarpelli R, Perez DI, Andrisano V, Perez-Castillo A, Monti B, Massenzio F, Polito L, Racchi M, Favia AD, Bottegoni G, Martinez A, Bolognesi ML, Cavalli A. PMID: 25504761.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    33. Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions. Biochemistry. 2014 Aug 12; 53(31):5140-9. Shang Y, LeRouzic V, Schneider S, Bisignano P, Pasternak GW, Filizola M. PMID: 25073009; PMCID: PMC4131901.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    34. Kinetic characterization of fragment binding in AmpC β-lactamase by high-throughput molecular simulations. J Chem Inf Model. 2014 Feb 24; 54(2):362-6. Bisignano P, Doerr S, Harvey MJ, Favia AD, Cavalli A, De Fabritiis G. PMID: 24444037.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    35. In silico deconstruction of ATP-competitive inhibitors of glycogen synthase kinase-3β. J Chem Inf Model. 2012 Dec 21; 52(12):3233-44. Bisignano P, Lambruschini C, Bicego M, Murino V, Favia AD, Cavalli A. PMID: 23198830.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    36. PLI: a web-based tool for the comparison of protein-ligand interactions observed on PDB structures. Bioinformatics. 2013 Feb 01; 29(3):395-7. Gallina AM, Bisignano P, Bergamino M, Bordo D. PMID: 23196990.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    37. SERAPhiC: a benchmark for in silico fragment-based drug design. J Chem Inf Model. 2011 Nov 28; 51(11):2882-96. Favia AD, Bottegoni G, Nobeli I, Bisignano P, Cavalli A. PMID: 21936510.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    38. An innovative protocol for comparing protein binding site via atomic grid maps. KDIR. 2011; 413-422. Bicego M., Favia A. D., Bisignano, P, Cavalli, A., and Murino, V.
    39. Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR-nucleotide binding domain 1. Biochimie. 2010 Jan; 92(1):51-7. Bisignano P, Moran O. PMID: 19781595.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
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