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Paul Schnier, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentInstitute for Neurodegenerative Diseases
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    UC BerkeleyPh.D.1998Department of Chemistry
    SUNY BinghamtonB.S.1993Mathematics

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Campuzano ID, Li H, Bagal D, Lippens JL, Svitel J, Kurzeja RJ, Xu H, Schnier P, Loo JA. Native MS Analysis of Bacteriorhodopsin and an Empty Nanodisc by Orthogonal Acceleration Time-of-Flight, Orbitrap and Ion Cyclotron Resonance. Anal Chem. 2016 Dec 20; 88(24):12427-12436. PMID: 28193065.
      View in: PubMed
    2. Noland CL, Gierke S, Schnier P, Murray J, Sandoval WN, Sagolla M, Dey A, Hannoush RN, Fairbrother WJ, Cunningham CN. Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling. Structure. 2016 Jan 05; 24(1):179-186. PMID: 26724994.
      View in: PubMed
    3. Poppe L, Jordan JB, Rogers G, Schnier P. Correction to On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Anal Chem. 2015 Jul 21; 87(14):7493. PMID: 26125133.
      View in: PubMed
    4. Poppe L, Jordan JB, Rogers G, Schnier P. On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Anal Chem. 2015 Jun 02; 87(11):5539-45. PMID: 25929316.
      View in: PubMed
    5. Raina M, Moghal A, Kano A, Jerums M, Schnier P, Luo S, Deshpande R, Bondarenko PV, Lin H, Ibba M. Reduced amino acid specificity of mammalian tyrosyl-tRNA synthetase is associated with elevated mistranslation of Tyr codons. J Biol Chem. 2014 Jun 20; 289(25):17780-90. PMID: 24828507; PMCID: PMC4067211.
    6. Liu L, Baergen A, Michelsen K, Kitova EN, Schnier P, Klassen JS. Energetics of intermolecular hydrogen bonds in a hydrophobic protein cavity. J Am Soc Mass Spectrom. 2014 May; 25(5):742-50. PMID: 24658798.
      View in: PubMed
    7. Kevany BM, Tsybovsky Y, Campuzano ID, Schnier P, Engel A, Palczewski K. Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. J Biol Chem. 2013 Dec 20; 288(51):36272-84. PMID: 24196967; PMCID: PMC3868743.
    8. Poppe L, Jordan JB, Lawson K, Jerums M, Apostol I, Schnier P. Profiling formulated monoclonal antibodies by (1)H NMR spectroscopy. Anal Chem. 2013 Oct 15; 85(20):9623-9. PMID: 24006877.
      View in: PubMed
    9. Michelsen K, Jordan JB, Lewis J, Long AM, Yang E, Rew Y, Zhou J, Yakowec P, Schnier P, Huang X, Poppe L. Ordering of the N-terminus of human MDM2 by small molecule inhibitors. J Am Chem Soc. 2012 Oct 17; 134(41):17059-67. PMID: 22991965.
      View in: PubMed
    10. Liu L, Michelsen K, Kitova EN, Schnier P, Brown A, Klassen JS. Deuterium kinetic isotope effects on the dissociation of a protein-fatty acid complex in the gas phase. J Am Chem Soc. 2012 Apr 04; 134(13):5931-7. PMID: 22409493.
      View in: PubMed
    11. Liu L, Michelsen K, Kitova EN, Schnier P, Klassen JS. Energetics of lipid binding in a hydrophobic protein cavity. J Am Chem Soc. 2012 Feb 15; 134(6):3054-60. PMID: 22280480.
      View in: PubMed
    12. Kitova EN, El-Hawiet A, Schnier P, Klassen JS. Reliable determinations of protein-ligand interactions by direct ESI-MS measurements. Are we there yet? J Am Soc Mass Spectrom. 2012 Mar; 23(3):431-41. PMID: 22270873.
      View in: PubMed
    13. Jordan JB, Poppe L, Xia X, Cheng AC, Sun Y, Michelsen K, Eastwood H, Schnier P, Nixey T, Zhong W. Fragment based drug discovery: practical implementation based on ยน?F NMR spectroscopy. J Med Chem. 2012 Jan 26; 55(2):678-87. PMID: 22165820.
      View in: PubMed
    14. Poppe L, Hui JO, Ligutti J, Murray JK, Schnier P. PADLOC: a powerful tool to assign disulfide bond connectivities in peptides and proteins by NMR spectroscopy. Anal Chem. 2012 Jan 03; 84(1):262-6. PMID: 22126836.
      View in: PubMed
    15. Qu Y, Schnier P, Zanon R, Vargas HM. hERG potency estimates based upon dose solution analysis: What have we learned? J Pharmacol Toxicol Methods. 2011 Nov-Dec; 64(3):251-7. PMID: 21888984.
      View in: PubMed
    16. Liu L, Michelsen K, Kitova EN, Schnier P, Klassen JS. Evidence that water can reduce the kinetic stability of protein-hydrophobic ligand interactions. J Am Chem Soc. 2010 Dec 22; 132(50):17658-60. PMID: 21121620.
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    17. Valliere-Douglass JF, Connell-Crowley L, Jensen R, Schnier P, Trilisky E, Leith M, Follstad BD, Kerr J, Lewis N, Vunnum S, Treuheit MJ, Balland A, Wallace A. Photochemical degradation of citrate buffers leads to covalent acetonation of recombinant protein therapeutics. Protein Sci. 2010 Nov; 19(11):2152-63. PMID: 20836085; PMCID: PMC3005786.
    18. Bagal D, Valliere-Douglass JF, Balland A, Schnier P. Resolving disulfide structural isoforms of IgG2 monoclonal antibodies by ion mobility mass spectrometry. Anal Chem. 2010 Aug 15; 82(16):6751-5. PMID: 20704363.
      View in: PubMed
    19. Beel AJ, Barrett P, Schnier P, Hitchcock SA, Bagal D, Sanders CR, Jordan JB. Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein. Biochemistry. 2009 Dec 22; 48(50):11837-9. PMID: 19928774; PMCID: PMC2794937.
    20. Liu L, Bagal D, Kitova EN, Schnier P, Klassen JS. Hydrophobic protein-ligand interactions preserved in the gas phase. J Am Chem Soc. 2009 Nov 11; 131(44):15980-1. PMID: 19886690.
      View in: PubMed
    21. Bagal D, Kitova EN, Liu L, El-Hawiet A, Schnier P, Klassen JS. Gas phase stabilization of noncovalent protein complexes formed by electrospray ionization. Anal Chem. 2009 Sep 15; 81(18):7801-6. PMID: 19746998.
      View in: PubMed
    22. Khera S, Grillo M, Schnier P, Hollis S. Application of diffusion-edited NMR spectroscopy for the structural characterization of drug metabolites in mixtures. J Pharm Biomed Anal. 2010 Jan 05; 51(1):164-9. PMID: 19656649.
      View in: PubMed
    23. Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier P, Harvey TS, Miranda LP, Cheetham J, Sasu BJ. Hepcidin revisited, disulfide connectivity, dynamics, and structure. J Biol Chem. 2009 Sep 04; 284(36):24155-67. PMID: 19553669; PMCID: PMC2782009.
    24. Bagal D, Zhang H, Schnier P. Gas-phase proton-transfer chemistry coupled with TOF mass spectrometry and ion mobility-MS for the facile analysis of poly(ethylene glycols) and PEGylated polypeptide conjugates. Anal Chem. 2008 Apr 01; 80(7):2408-18. PMID: 18324791.
      View in: PubMed
    25. Kruppa G, Schnier P, Tabei K, Van Orden S, Siegel MM. Multiple ion isolation applications in FT-ICR MS: exact-mass MSn internal calibration and purification/interrogation of protein-drug complexes. Anal Chem. 2002 Aug 01; 74(15):3877-86. PMID: 12175179.
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    26. Van Berkel GJ, Asano KG, Schnier P. Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter. J Am Soc Mass Spectrom. 2001 Jul; 12(7):853-62. PMID: 11444609.
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    27. Strittmatter EF, Schnier P, Klassen JS, Williams ER. Dissociation energies of deoxyribose nucleotide dimer anions measured using blackbody infrared radiative dissociation. J Am Soc Mass Spectrom. 1999 Nov; 10(11):1095-104. PMID: 10536816; PMCID: PMC1409745.
    28. Schnier P, Jurchen JC, Williams ER. The effective temperature of Peptide ions dissociated by sustained off-resonance irradiation collisional activation in fourier transform mass spectrometry. J Phys Chem B. 1999 Jan 28; 103(4):737-45. PMID: 16614752; PMCID: PMC1435862.
    29. Klassen JS, Schnier P, Williams ER. Blackbody infrared radiative dissociation of oligonucleotide anions. J Am Soc Mass Spectrom. 1998 Nov; 9(11):1117-24. PMID: 9794082; PMCID: PMC1343443.
    30. Schnier P, Klassen JS, Strittmatter EF, Williams ER. Activation energies for dissociation of double strand oligonucleotide anions: evidence for watson-crick base pairing in vacuo. J Am Chem Soc. 1998 Sep 23; 120(37):9605-13. PMID: 16498487; PMCID: PMC1380309.
    31. Schnier P, Williams ER. Analysis of isomeric mixtures using blackbody infrared radiative dissociation: determining isomeric purity and obtaining individual tandem mass spectra simultaneously. Anal Chem. 1998 Jul 15; 70(14):3033-41. PMID: 9684551; PMCID: PMC1343442.
    32. Schnier P, Price WD, Strittmatter EF, Williams ER. Dissociation energetics and mechanisms of leucine enkephalin (M + H)+ and (2M + X)+ ions (X = H, Li, Na, K, and Rb) measured by blackbody infrared radiative dissociation. J Am Soc Mass Spectrom. 1997 Aug; 8(8):771-80. PMID: 16554908; PMCID: PMC1409762.
    33. Jockusch RA, Schnier P, Price WD, Strittmatter EF, Demirev PA, Williams ER. Effects of charge state on fragmentation pathways, dynamics, and activation energies of ubiquitin ions measured by blackbody infrared radiative dissociation. Anal Chem. 1997 Mar 15; 69(6):1119-26. PMID: 9075403; PMCID: PMC1434665.
    34. Price WD, Schnier P, Williams ER. Binding energies of the proton-bound amino Acid dimers gly.gly, ala.ala, gly.ala, and lys.lys measured by blackbody infrared radiative dissociation. J Phys Chem B. 1997 Jan 23; 101(4):664-73. PMID: 17235378; PMCID: PMC1776505.
    35. Price WD, Schnier P, Jockusch RA, Strittmatter EF, Williams ER. Unimolecular reaction kinetics in the high-pressure limit without collisions. J Am Chem Soc. 1996 Oct 30; 118(43):10640-4. PMID: 16467929; PMCID: PMC1357232.
    36. Schnier P, Price WD, Williams ER. Modeling the maximum charge state of arginine-containing Peptide ions formed by electrospray ionization. J Am Soc Mass Spectrom. 1996 Sep; 7(9):972-6. PMID: 16467911; PMCID: PMC1350975.
    37. Schnier P, Price WD, Jockusch RA, Williams ER. Blackbody infrared radiative dissociation of bradykinin and its analogues: energetics, dynamics, and evidence for salt-bridge structures in the gas phase. J Am Chem Soc. 1996 Jul 31; 118(30):7178-89. PMID: 16525512; PMCID: PMC1393282.
    38. Gross DS, Schnier P, Rodriguez-Cruz SE, Fagerquist CK, Williams ER. Conformations and folding of lysozyme ions in vacuo. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):3143-8. PMID: 8610183; PMCID: PMC39776.
    39. Price WD, Schnier P, Williams ER. Tandem mass spectrometry of large biomolecule ions by blackbody infrared radiative dissociation. Anal Chem. 1996 Mar 01; 68(5):859-66. PMID: 21619182.
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    40. Schnier P, Gross DS, Williams ER. On the maximum charge state and proton transfer reactivity of peptide and protein ions formed by electrospray ionization. J Am Soc Mass Spectrom. 1995 Nov; 6(11):1086-97. PMID: 24214055.
      View in: PubMed
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