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Paul Schnier, PhD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
DepartmentInstitute for Neurodegenerative Diseases
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    UC BerkeleyPh.D.1998Department of Chemistry
    SUNY BinghamtonB.S.1993Mathematics

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yang B, Wu H, Schnier PD, Liu Y, Liu J, Wang N, DeGrado WF, Wang L. Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry. Proc Natl Acad Sci U S A. 2018 Oct 15. PMID: 30322930.
      View in: PubMed
    2. Lombana TN, Matsumoto ML, Bevers Iii J, Berkley AM, Toy E, Cook R, Gan Y, Du C, Liu P, Schnier P, Sandoval W, Ye Z, Schartner JM, Kim J, Spiess C. High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies. MAbs. 2018 Oct 11. PMID: 30307368.
      View in: PubMed
    3. Campuzano ID, Li H, Bagal D, Lippens JL, Svitel J, Kurzeja RJ, Xu H, Schnier PD, Loo JA. Native MS Analysis of Bacteriorhodopsin and an Empty Nanodisc by Orthogonal Acceleration Time-of-Flight, Orbitrap and Ion Cyclotron Resonance. Anal Chem. 2016 Dec 20; 88(24):12427-12436. PMID: 28193065.
      View in: PubMed
    4. Noland CL, Gierke S, Schnier PD, Murray J, Sandoval WN, Sagolla M, Dey A, Hannoush RN, Fairbrother WJ, Cunningham CN. Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling. Structure. 2016 Jan 05; 24(1):179-186. PMID: 26724994.
      View in: PubMed
    5. Poppe L, Jordan JB, Rogers G, Schnier PD. Correction to On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Anal Chem. 2015 Jul 21; 87(14):7493. PMID: 26125133.
      View in: PubMed
    6. Poppe L, Jordan JB, Rogers G, Schnier PD. On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Anal Chem. 2015 Jun 02; 87(11):5539-45. PMID: 25929316.
      View in: PubMed
    7. Raina M, Moghal A, Kano A, Jerums M, Schnier PD, Luo S, Deshpande R, Bondarenko PV, Lin H, Ibba M. Reduced amino acid specificity of mammalian tyrosyl-tRNA synthetase is associated with elevated mistranslation of Tyr codons. J Biol Chem. 2014 Jun 20; 289(25):17780-90. PMID: 24828507; PMCID: PMC4067211.
    8. Liu L, Baergen A, Michelsen K, Kitova EN, Schnier PD, Klassen JS. Energetics of intermolecular hydrogen bonds in a hydrophobic protein cavity. J Am Soc Mass Spectrom. 2014 May; 25(5):742-50. PMID: 24658798.
      View in: PubMed
    9. Kevany BM, Tsybovsky Y, Campuzano ID, Schnier PD, Engel A, Palczewski K. Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. J Biol Chem. 2013 Dec 20; 288(51):36272-84. PMID: 24196967; PMCID: PMC3868743.
    10. Poppe L, Jordan JB, Lawson K, Jerums M, Apostol I, Schnier PD. Profiling formulated monoclonal antibodies by (1)H NMR spectroscopy. Anal Chem. 2013 Oct 15; 85(20):9623-9. PMID: 24006877.
      View in: PubMed
    11. Michelsen K, Jordan JB, Lewis J, Long AM, Yang E, Rew Y, Zhou J, Yakowec P, Schnier PD, Huang X, Poppe L. Ordering of the N-terminus of human MDM2 by small molecule inhibitors. J Am Chem Soc. 2012 Oct 17; 134(41):17059-67. PMID: 22991965.
      View in: PubMed
    12. Liu L, Michelsen K, Kitova EN, Schnier PD, Brown A, Klassen JS. Deuterium kinetic isotope effects on the dissociation of a protein-fatty acid complex in the gas phase. J Am Chem Soc. 2012 Apr 04; 134(13):5931-7. PMID: 22409493.
      View in: PubMed
    13. Liu L, Michelsen K, Kitova EN, Schnier PD, Klassen JS. Energetics of lipid binding in a hydrophobic protein cavity. J Am Chem Soc. 2012 Feb 15; 134(6):3054-60. PMID: 22280480.
      View in: PubMed
    14. Kitova EN, El-Hawiet A, Schnier PD, Klassen JS. Reliable determinations of protein-ligand interactions by direct ESI-MS measurements. Are we there yet? J Am Soc Mass Spectrom. 2012 Mar; 23(3):431-41. PMID: 22270873.
      View in: PubMed
    15. Jordan JB, Poppe L, Xia X, Cheng AC, Sun Y, Michelsen K, Eastwood H, Schnier PD, Nixey T, Zhong W. Fragment based drug discovery: practical implementation based on ยน?F NMR spectroscopy. J Med Chem. 2012 Jan 26; 55(2):678-87. PMID: 22165820.
      View in: PubMed
    16. Poppe L, Hui JO, Ligutti J, Murray JK, Schnier PD. PADLOC: a powerful tool to assign disulfide bond connectivities in peptides and proteins by NMR spectroscopy. Anal Chem. 2012 Jan 03; 84(1):262-6. PMID: 22126836.
      View in: PubMed
    17. Qu Y, Schnier P, Zanon R, Vargas HM. hERG potency estimates based upon dose solution analysis: What have we learned? J Pharmacol Toxicol Methods. 2011 Nov-Dec; 64(3):251-7. PMID: 21888984.
      View in: PubMed
    18. Liu L, Michelsen K, Kitova EN, Schnier PD, Klassen JS. Evidence that water can reduce the kinetic stability of protein-hydrophobic ligand interactions. J Am Chem Soc. 2010 Dec 22; 132(50):17658-60. PMID: 21121620.
      View in: PubMed
    19. Valliere-Douglass JF, Connell-Crowley L, Jensen R, Schnier PD, Trilisky E, Leith M, Follstad BD, Kerr J, Lewis N, Vunnum S, Treuheit MJ, Balland A, Wallace A. Photochemical degradation of citrate buffers leads to covalent acetonation of recombinant protein therapeutics. Protein Sci. 2010 Nov; 19(11):2152-63. PMID: 20836085; PMCID: PMC3005786.
    20. Bagal D, Valliere-Douglass JF, Balland A, Schnier PD. Resolving disulfide structural isoforms of IgG2 monoclonal antibodies by ion mobility mass spectrometry. Anal Chem. 2010 Aug 15; 82(16):6751-5. PMID: 20704363.
      View in: PubMed
    21. Beel AJ, Barrett P, Schnier PD, Hitchcock SA, Bagal D, Sanders CR, Jordan JB. Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein. Biochemistry. 2009 Dec 22; 48(50):11837-9. PMID: 19928774; PMCID: PMC2794937.
    22. Liu L, Bagal D, Kitova EN, Schnier PD, Klassen JS. Hydrophobic protein-ligand interactions preserved in the gas phase. J Am Chem Soc. 2009 Nov 11; 131(44):15980-1. PMID: 19886690.
      View in: PubMed
    23. Bagal D, Kitova EN, Liu L, El-Hawiet A, Schnier PD, Klassen JS. Gas phase stabilization of noncovalent protein complexes formed by electrospray ionization. Anal Chem. 2009 Sep 15; 81(18):7801-6. PMID: 19746998.
      View in: PubMed
    24. Khera S, Grillo M, Schnier P, Hollis S. Application of diffusion-edited NMR spectroscopy for the structural characterization of drug metabolites in mixtures. J Pharm Biomed Anal. 2010 Jan 05; 51(1):164-9. PMID: 19656649.
      View in: PubMed
    25. Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier PD, Harvey TS, Miranda LP, Cheetham J, Sasu BJ. Hepcidin revisited, disulfide connectivity, dynamics, and structure. J Biol Chem. 2009 Sep 04; 284(36):24155-67. PMID: 19553669; PMCID: PMC2782009.
    26. Bagal D, Zhang H, Schnier PD. Gas-phase proton-transfer chemistry coupled with TOF mass spectrometry and ion mobility-MS for the facile analysis of poly(ethylene glycols) and PEGylated polypeptide conjugates. Anal Chem. 2008 Apr 01; 80(7):2408-18. PMID: 18324791.
      View in: PubMed
    27. Kruppa G, Schnier PD, Tabei K, Van Orden S, Siegel MM. Multiple ion isolation applications in FT-ICR MS: exact-mass MSn internal calibration and purification/interrogation of protein-drug complexes. Anal Chem. 2002 Aug 01; 74(15):3877-86. PMID: 12175179.
      View in: PubMed