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Peder Larson, PhD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
DepartmentRadiology
Address1700 4th St
San Francisco CA 94158
Phone415-514-4876
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBS2002Electrical Engineering & Mathematics
    Stanford UniversityMS2003Electrical Engineering
    Stanford UniversityPhD2007Electrical Engineering
    University of California, San FranciscoPostdoctoral Scholar2011Radiology and Biomedical Imaging
    Collapse Awards and Honors
    Magnetic Resonance in Medicine2018Editors Pick "In vivo characterization of brain ultrashort-T2 components"
    Magnetic Resonance in Medicine2010  - 2017Distinguished Reviewer
    International Society for Magnetic Resonance in Medicine2011Junior Fellow
    University of California, San Francisco2011Surbeck Scholar Award, 1st place
    University of California, San Francisco2010Surbeck Scholar Award, 1st place
    National Science Foundation Graduate Fellowship2003Honorable Mention

    Collapse Overview 
    Collapse Overview
    Peder Larson, PhD, is an Associate Professor in Residence and a Principal Investigator in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Larson's research program is primarily centered around developing new MRI scanning and reconstruction technology for improved clinical outcomes. These developments in his group are aimed at several applications:

    Metabolic imaging methods using hyperpolarized carbon-13 MRI
    This exciting new imaging modality in currently in Phase I and Phase II clinical trials for oncologic applications, and Dr. Larson's group is responsible for the scanning methods used in these trials. His group is also developing new methods, aimed to provide faster, more accurate and higher-resolution imaging as well as generate new types of information and image contrast.

    Semi-solid tissue MRI
    Conventional MRI does not detect semi-solid tissues, such as tendons and cortical bone, as well as components of myelin, ligaments, menisci, other connective tissues, and lung parenchyma. Dr. Larson’s groups is actively developing advanced semi-solid tissue MRI methods, and pursuing clinical applications in tendon, bone, myelin, and lung imaging.

    PET/MRI
    Recently introduced hybrid PET/MRI systems combine the exceptional soft-tissue contrast of MRI with the functional contrast of PET. Dr. Larson's group is developing MRI methods for these systems to provide improved quantification, image quality and SNR in a clinical setting.


    Dr. Larson is an active member of International Society for Magnetic Resonance in Medicine, the Institute for Electrical and Electronics Engineering, the UC Berkeley and UCSF Graduate Group in Bioengineering, and the California Institute for Quantitative Biosciences.


    Education and Training:
    • Bachelor of Science: Stanford University, California - Electrical Engineering and Mathematics
    • Masters of Science: Stanford University, California - Electrical Engineering
    • Doctor of Philosophy: Stanford University, California - Electrical Engineering
    • Postdoctoral Fellowship: University of California, San Francisco - Radiology and Biomedical Imaging


    Collapse Research 
    Collapse Research Activities and Funding
    MRI methods for high resolution imaging of the lung
    NIH/NHLBI R01HL136965Apr 15, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Novel Ultrashort Echo Time Sequences for Brain MRI
    NIH/NINDS R21NS089004Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and Metabolism
    NIH/NIBIB R01EB016741Sep 17, 2014 - May 31, 2018
    Role: Principal Investigator
    Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast
    NIH/NIBIB R00EB012064Sep 1, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast
    NIH/NIBIB K99EB012064Sep 1, 2010 - Aug 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Coello E, Noeske R, Burns BL, Gordon JW, Jakary A, Menze B, Haase A, Larson P, Li Y, Schulte RF. High-resolution echo-planar spectroscopic imaging at ultra-high field. NMR Biomed. 2018 Jul 27; e3950. PMID: 30052300.
      View in: PubMed
    2. Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson P. Spatio-temporally constrained reconstruction for hyperpolarized carbon-13 MRI using kinetic models. IEEE Trans Med Imaging. 2018 Jun 05. PMID: 29994332.
      View in: PubMed
    3. Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson P, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration. Spine (Phila Pa 1976). 2018 May 15; 43(10):E592-E600. PMID: 28984733.
      View in: PubMed
    4. Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson P, Wilson M, Martin AJ, Hetts SW. Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences. J Magn Reson Imaging. 2018 May 14. PMID: 29761624.
      View in: PubMed
    5. Wei H, Cao P, Bischof A, Henry RG, Larson P, Liu C. MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation. Neuroimage. 2018 Mar 29; 175:1-11. PMID: 29604452.
      View in: PubMed
    6. Chen HY, Larson P, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB. Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer. Magn Reson Med. 2018 Mar 25. PMID: 29575178.
      View in: PubMed
    7. Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Larson P, Vigneron DB. Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized 13C imaging using the bSSFP sequence. J Magn Reson. 2018 May; 290:46-59. PMID: 29567434.
      View in: PubMed
    8. Jiang W, Larson P, Lustig M. Simultaneous auto-calibration and gradient delays estimation (SAGE) in non-Cartesian parallel MRI using low-rank constraints. Magn Reson Med. 2018 Mar 09. PMID: 29524244.
      View in: PubMed
    9. von Morze C, Reed GD, Larson P, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME. In vivo hyperpolarization transfer in a clinical MRI scanner. Magn Reson Med. 2018 Feb 27. PMID: 29488244.
      View in: PubMed
    10. Wiesinger F, Bylund M, Yang J, Kaushik S, Shanbhag D, Ahn S, Jonsson JH, Lundman JA, Hope T, Nyholm T, Larson P, Cozzini C. Zero TE-based pseudo-CT image conversion in the head and its application in PET/MR attenuation correction and MR-guided radiation therapy planning. Magn Reson Med. 2018 Feb 18. PMID: 29457287.
      View in: PubMed
    11. Milshteyn E, von Morze C, Gordon JW, Zhu Z, Larson P, Vigneron DB. High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate with spectral suppression of alanine and pyruvate-hydrate. Magn Reson Med. 2018 Feb 16. PMID: 29451329.
      View in: PubMed
    12. Gordon JW, Hansen RB, Shin PJ, Feng Y, Vigneron DB, Larson P. 3D hyperpolarized C-13 EPI with calibrationless parallel imaging. J Magn Reson. 2018 Apr; 289:92-99. PMID: 29476930.
      View in: PubMed
    13. Park I, Larson P, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ. Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies. Magn Reson Med. 2018 Jan 10. PMID: 29322616.
      View in: PubMed
    14. Boucneau T, Cao P, Tang S, Han M, Xu D, Henry RG, Larson P. In vivo characterization of brain ultrashort-T2 components. Magn Reson Med. 2018 Aug; 80(2):726-735. PMID: 29194734.
      View in: PubMed
    15. Leynes AP, Yang J, Wiesinger F, Kaushik SS, Shanbhag DD, Seo Y, Hope TA, Larson P. Zero-Echo-Time and Dixon Deep Pseudo-CT (ZeDD CT): Direct Generation of Pseudo-CT Images for Pelvic PET/MRI Attenuation Correction Using Deep Convolutional Neural Networks with Multiparametric MRI. J Nucl Med. 2018 May; 59(5):852-858. PMID: 29084824.
      View in: PubMed
    16. Cao P, Zhu X, Tang S, Leynes A, Jakary A, Larson P. Shuffled magnetization-prepared multicontrast rapid gradient-echo imaging. Magn Reson Med. 2018 Jan; 79(1):62-70. PMID: 29080236.
      View in: PubMed
    17. Li Y, Bian W, Larson P, Crane JC, Parvathaneni P, Nagarajan S, Nelson SJ. Reliable and Reproducible GABA Measurements Using Automated Spectral Prescription at Ultra-High Field. Front Hum Neurosci. 2017; 11:506. PMID: 29118697.
      View in: PubMed
    18. Chiew M, Jiang W, Burns B, Larson P, Steel A, Jezzard P, Albert Thomas M, Emir UE. Density-weighted concentric rings k-space trajectory for 1 H magnetic resonance spectroscopic imaging at 7 T. NMR Biomed. 2017 Oct 18. PMID: 29044762.
      View in: PubMed
    19. Jiang W, Ong F, Johnson KM, Nagle SK, Hope TA, Lustig M, Larson P. Motion robust high resolution 3D free-breathing pulmonary MRI using dynamic 3D image self-navigator. Magn Reson Med. 2018 Jun; 79(6):2954-2967. PMID: 29023975.
      View in: PubMed
    20. Yang J, Wiesinger F, Kaushik S, Shanbhag D, Hope TA, Larson P, Seo Y. Evaluation of Sinus/Edge-Corrected Zero-Echo-Time-Based Attenuation Correction in Brain PET/MRI. J Nucl Med. 2017 Nov; 58(11):1873-1879. PMID: 28473594.
      View in: PubMed
    21. Korenchan DE, Taglang C, von Morze C, Blecha JE, Gordon JW, Sriram R, Larson P, Vigneron DB, VanBrocklin HF, Kurhanewicz J, Wilson DM, Flavell RR. Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging. Analyst. 2017 May 02; 142(9):1429-1433. PMID: 28322385.
      View in: PubMed
    22. Chen HY, Larson P, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB. Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. Cancer Res. 2017 06 15; 77(12):3207-3216. PMID: 28428273.
      View in: PubMed
    23. Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson P, Vigneron DB, Ohliger MA. Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver. J Magn Reson Imaging. 2018 Jan; 47(1):141-151. PMID: 28419644.
      View in: PubMed
    24. Ehman EC, Johnson GB, Villanueva-Meyer JE, Cha S, Leynes AP, Larson P, Hope TA. PET/MRI: Where might it replace PET/CT? J Magn Reson Imaging. 2017 Nov; 46(5):1247-1262. PMID: 28370695.
      View in: PubMed
    25. Leynes AP, Yang J, Shanbhag DD, Kaushik SS, Seo Y, Hope TA, Wiesinger F, Larson P. Hybrid ZTE/Dixon MR-based attenuation correction for quantitative uptake estimation of pelvic lesions in PET/MRI. Med Phys. 2017 Mar; 44(3):902-913. PMID: 28112410.
      View in: PubMed
    26. Yang J, Jian Y, Jenkins N, Behr SC, Hope TA, Larson P, Vigneron D, Seo Y. Quantitative Evaluation of Atlas-based Attenuation Correction for Brain PET in an Integrated Time-of-Flight PET/MR Imaging System. Radiology. 2017 07; 284(1):169-179. PMID: 28234560.
      View in: PubMed
    27. Trudel G, Melkus G, Cron GO, Louati H, Sheikh A, Larson P, Schweitzer M, Lapner P, Uhthoff HK, Laneuville O. Imaging of the rabbit supraspinatus enthesis at 7 Tesla: a 4-week time course after repair surgery and effect of channeling. J Magn Reson Imaging. 2017 Aug; 46(2):461-467. PMID: 28152242.
      View in: PubMed
    28. Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson P, Vigneron DB. Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques. Magn Reson Imaging. 2017 05; 38:152-162. PMID: 28077268.
      View in: PubMed
    29. Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson P, Vigneron DB, Merritt M. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone. Magn Reson Med. 2017 Jan; 77(1):65-73. PMID: 27859575.
      View in: PubMed
    30. Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson P, Pauly JM, Vigneron DB. Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses. Magn Reson Med. 2017 Sep; 78(3):963-975. PMID: 27770458.
      View in: PubMed
    31. Gordon JW, Milshteyn E, Marco-Rius I, Ohliger M, Vigneron DB, Larson P. Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects. Magn Reson Med. 2017 Sep; 78(3):1087-1092. PMID: 27735082.
      View in: PubMed
    32. Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson P, Kurhanewicz J. Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR. J Magn Reson. 2016 09; 270:115-123. PMID: 27434780.
      View in: PubMed
    33. Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson P, Bok R, Chen HY, Kurhanewicz J, Vigneron D. Combining hyperpolarized 13 C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism. Magn Reson Med. 2017 Jun; 77(6):2356-2363. PMID: 27298073.
      View in: PubMed
    34. Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson P, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135. PMID: 27570835.
      View in: PubMed
    35. Maidens J, Gordon JW, Arcak M, Larson P. Optimizing Flip Angles for Metabolic Rate Estimation in Hyperpolarized Carbon-13 MRI. IEEE Trans Med Imaging. 2016 11; 35(11):2403-2412. PMID: 27249825.
      View in: PubMed
    36. Cao P, Shin PJ, Park I, Najac C, Marco-Rius I, Vigneron DB, Nelson SJ, Ronen SM, Larson P. Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing. Magn Reson Med. 2016 08; 76(2):369-79. PMID: 27228088.
      View in: PubMed
    37. von Morze C, Chang GY, Larson P, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB. Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver. Magn Reson Med. 2017 Apr; 77(4):1429-1437. PMID: 27098724.
      View in: PubMed
    38. Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson P, Vigneron DB. Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies. Magn Reson Med. 2017 Apr; 77(4):1419-1428. PMID: 27017966.
      View in: PubMed
    39. Gordon JW, Vigneron DB, Larson P. Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized 13 C imaging. Magn Reson Med. 2017 Feb; 77(2):826-832. PMID: 26898849.
      View in: PubMed
    40. Larson P, Han M, Krug R, Jakary A, Nelson SJ, Vigneron DB, Henry RG, McKinnon G, Kelley DA. Ultrashort echo time and zero echo time MRI at 7T. MAGMA. 2016 Jun; 29(3):359-70. PMID: 26702940; PMCID: PMC4892974 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    41. Shang H, Larson P, Kerr A, Reed G, Sukumar S, Elkhaled A, Gordon JW, Ohliger MA, Pauly JM, Lustig M, Vigneron DB. Multiband RF pulses with improved performance via convex optimization. J Magn Reson. 2016 Jan; 262:81-90. PMID: 26754063.
      View in: PubMed
    42. Cao P, Zhang X, Park I, Najac C, Nelson SJ, Ronen S, Larson P. 1 H-13 C independently tuned radiofrequency surface coil applied for in vivo hyperpolarized MRI. Magn Reson Med. 2016 11; 76(5):1612-1620. PMID: 26597845.
      View in: PubMed
    43. Feng Y, Gordon JW, Shin PJ, von Morze C, Lustig M, Larson P, Ohliger MA, Carvajal L, Tropp J, Pauly JM, Vigneron DB. Development and testing of hyperpolarized (13)C MR calibrationless parallel imaging. J Magn Reson. 2016 Jan; 262:1-7. PMID: 26679288; PMCID: PMC4864033 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    44. Xie L, Layton AT, Wang N, Larson P, Zhang JL, Lee VS, Liu C, Johnson GA. Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function. Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F174-82. PMID: 26447222; PMCID: PMC4719043 [Available on 01/15/17].
      View in: PubMed, PubMed Central
    45. Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson P, Kurhanewicz J, Wilson DM. Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb). 2015 Sep 25; 51(74):14119-22. PMID: 26257040; PMCID: PMC4854286.
      View in: PubMed, PubMed Central
    46. Han M, Rieke V, Scott SJ, Ozhinsky E, Salgaonkar VA, Jones PD, Larson P, Diederich CJ, Krug R. Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI. Magn Reson Med. 2015 Dec; 74(6):1548-55. PMID: 26390357; PMCID: PMC4715675 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    47. Burris NS, Johnson KM, Larson P, Hope MD, Nagle SK, Behr SC, Hope TA. Detection of Small Pulmonary Nodules with Ultrashort Echo Time Sequences in Oncology Patients by Using a PET/MR System. Radiology. 2016 Jan; 278(1):239-46. PMID: 26133050; PMCID: PMC4699498 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    48. Leon Swisher C, Koelsch B, Sukumar S, Sriram R, Santos RD, Wang ZJ, Kurhanewicz J, Vigneron D, Larson P. Dynamic UltraFast 2D EXchange SpectroscopY (UF-EXSY) of hyperpolarized substrates. J Magn Reson. 2015 Aug; 257:102-9. PMID: 26117655; PMCID: PMC4515769.
      View in: PubMed, PubMed Central
    49. Shang H, Skloss T, von Morze C, Carvajal L, Van Criekinge M, Milshteyn E, Larson P, Hurd RE, Vigneron DB. Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples. Magn Reson Med. 2016 Feb; 75(2):917-22. PMID: 25765516; PMCID: PMC4567531 [Available on 02/01/17].
      View in: PubMed, PubMed Central
    50. Jiang W, Lustig M, Larson P. Concentric rings K-space trajectory for hyperpolarized (13)C MR spectroscopic imaging. Magn Reson Med. 2016 Jan; 75(1):19-31. PMID: 25533653; PMCID: PMC4476971 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    51. Bian W, Banerjee S, Kelly DA, Hess CP, Larson P, Chang SM, Nelson SJ, Lupo JM. Simultaneous imaging of radiation-induced cerebral microbleeds, arteries and veins, using a multiple gradient echo sequence at 7 Tesla. J Magn Reson Imaging. 2015 Aug; 42(2):269-79. PMID: 25471321; PMCID: PMC4876721.
      View in: PubMed, PubMed Central
    52. Shin PJ, Larson P, Uecker M, Reed GD, Kerr AB, Tropp J, Ohliger MA, Nelson SJ, Pauly JM, Lustig M, Vigneron DB. Chemical shift separation with controlled aliasing for hyperpolarized (13) C metabolic imaging. Magn Reson Med. 2015 Oct; 74(4):978-89. PMID: 25298086; PMCID: PMC4390401 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    53. Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson P. Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites. Magn Reson Med. 2015 Sep; 74(3):622-633. PMID: 25213126; PMCID: PMC4362805.
      View in: PubMed, PubMed Central
    54. Keshari KR, Wilson DM, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ. Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes. 2015 Feb; 64(2):344-52. PMID: 25187363; PMCID: PMC4303960.
      View in: PubMed, PubMed Central
    55. Wang YX, Lo GG, Yuan J, Larson P, Zhang X. Magnetic resonance imaging for lung cancer screen. J Thorac Dis. 2014 Sep; 6(9):1340-8. PMID: 25276380; PMCID: PMC4178109.
      View in: PubMed, PubMed Central
    56. Tang S, Jiang W, Chen HY, Bok R, Vigneron DB, Larson P. A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging. Magn Reson Med. 2015 Aug; 74(2):506-12. PMID: 25154961; PMCID: PMC4336852.
      View in: PubMed, PubMed Central
    57. Li Y, Larson P, Chen AP, Lupo JM, Ozhinsky E, Kelley D, Chang SM, Nelson SJ. Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels. J Magn Reson Imaging. 2015 May; 41(5):1332-41. PMID: 24935758; PMCID: PMC4269580.
      View in: PubMed, PubMed Central
    58. Chaumeil MM, Larson P, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res. 2014 Aug 15; 74(16):4247-57. PMID: 24876103; PMCID: PMC4134724.
      View in: PubMed, PubMed Central
    59. Han M, Larson P, Liu J, Krug R. Depiction of achilles tendon microstructure in vivo using high-resolution 3-dimensional ultrashort echo-time magnetic resonance imaging at 7 T. Invest Radiol. 2014 May; 49(5):339-45. PMID: 24500089; PMCID: PMC4143127.
      View in: PubMed, PubMed Central
    60. Bahrami N, Swisher CL, Von Morze C, Vigneron DB, Larson P. Kinetic and perfusion modeling of hyperpolarized (13)C pyruvate and urea in cancer with arbitrary RF flip angles. Quant Imaging Med Surg. 2014 Feb; 4(1):24-32. PMID: 24649432; PMCID: PMC3947982.
      View in: PubMed, PubMed Central
    61. Shin PJ, Larson P, Ohliger MA, Elad M, Pauly JM, Vigneron DB, Lustig M. Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion. Magn Reson Med. 2014 Oct; 72(4):959-70. PMID: 24248734; PMCID: PMC4025999.
      View in: PubMed, PubMed Central
    62. Park I, Larson P, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ. Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain. Magn Reson Med. 2014 Jan; 71(1):19-25. PMID: 24346964; PMCID: PMC4041734.
      View in: PubMed, PubMed Central
    63. Reed GD, von Morze C, Bok R, Koelsch BL, Van Criekinge M, Smith KJ. High resolution (13)C MRI with hyperpolarized urea: in vivo T(2) mapping and (15)N labeling effects. IEEE Trans Med Imaging. 2014 Feb; 33(2):362-71. PMID: 24235273; PMCID: PMC4011557.
      View in: PubMed, PubMed Central
    64. Nelson SJ, Kurhanewicz J, Vigneron DB, Larson P, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate. Sci Transl Med. 2013 Aug 14; 5(198):198ra108. PMID: 23946197.
      View in: PubMed
    65. Xing Y, Reed GD, Pauly JM, Kerr AB, Larson P. Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates. J Magn Reson. 2013 Sep; 234:75-81. PMID: 23845910.
      View in: PubMed
    66. Finsterbusch J, Busch MG, Larson P. Signal scaling improves the signal-to-noise ratio of measurements with segmented 2D-selective radiofrequency excitations. Magn Reson Med. 2013 Dec; 70(6):1491-9. PMID: 23440633; PMCID: PMC4987130.
      View in: PubMed, PubMed Central
    67. Koelsch BL, Keshari KR, Peeters TH, Larson P, Wilson DM, Kurhanewicz J. Diffusion MR of hyperpolarized 13C molecules in solution. Analyst. 2013 Feb 21; 138(4):1011-4. PMID: 23304699; PMCID: PMC3568999.
      View in: PubMed, PubMed Central
    68. Swisher CL, Larson P, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2014 Jan; 71(1):1-11. PMID: 23412881; PMCID: PMC3659200.
      View in: PubMed, PubMed Central
    69. Ohliger MA, Larson P, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013 Sep; 38(3):701-13. PMID: 23293097; PMCID: PMC3759833.
      View in: PubMed, PubMed Central
    70. Chaumeil MM, Larson P, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4:2429. PMID: 24019001; PMCID: PMC3908661.
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    71. Larson P, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2013 Jun; 31(5):635-42. PMID: 23260391; PMCID: PMC3626756.
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    72. Hu S, Larson P, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2013 May; 31(4):490-6. PMID: 23107275; PMCID: PMC3625683.
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    73. Larson P, Kerr AB, Swisher CL, Pauly JM, Vigneron DB. A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates. J Magn Reson. 2012 Dec; 225:71-80. PMID: 23143011; PMCID: PMC3531583.
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    74. von Morze C, Sukumar S, Reed GD, Larson P, Bok RA, Kurhanewicz J, Vigneron DB. Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T. Magn Reson Imaging. 2013 Feb; 31(2):163-70. PMID: 22898680; PMCID: PMC3651030.
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    75. Reed GD, Larson P, Morze Cv, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate. J Magn Reson. 2012 Apr; 217:41-7. PMID: 22405760; PMCID: PMC3326401.
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    76. von Morze C, Larson P, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea. Magn Reson Imaging. 2012 Apr; 30(3):305-11. PMID: 22169407; PMCID: PMC3393100.
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    77. Keshari KR, Kurhanewicz J, Bok R, Larson P, Vigneron DB, Wilson DM. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18606-11. PMID: 22042839; PMCID: PMC3219134.
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    78. Larson P, Kerr AB, Reed GD, Hurd RE, Kurhanewicz J, Pauly JM, Vigneron DB. Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging. IEEE Trans Med Imaging. 2012 Feb; 31(2):265-75. PMID: 22027366; PMCID: PMC3274664.
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    79. Hu S, Zhu M, Yoshihara HA, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson P, Kurhanewicz J, Vigneron DB. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging. 2011 Oct; 29(8):1035-40. PMID: 21855243; PMCID: PMC3172390.
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    80. Krug R, Larson P, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5. PMID: 21769960; PMCID: PMC3197976.
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    81. Hu S, Balakrishnan A, Bok RA, Anderton B, Larson P, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab. 2011 Jul 06; 14(1):131-42. PMID: 21723511; PMCID: PMC3858338.
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    82. Larson P, Gold GE. Science to practice: Can inflammatory arthritis be monitored by using MR imaging with injected hyperpolarized 13C-pyruvate? Radiology. 2011 May; 259(2):309-10. PMID: 21502386.
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    83. von Morze C, Reed G, Shin P, Larson P, Hu S, Bok R, Vigneron DB. Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate. J Magn Reson. 2011 Aug; 211(2):109-13. PMID: 21596601; PMCID: PMC3143308.
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    84. von Morze C, Larson P, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011 Mar; 33(3):692-7. PMID: 21563254; PMCID: PMC3566235.
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    85. Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson P, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2011 Jan; 208(1):171-7. PMID: 21130012; PMCID: PMC3387549.
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    86. Larson P, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB. Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med. 2011 Mar; 65(3):610-9. PMID: 20939089; PMCID: PMC3021589.
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    87. Dafni H, Larson P, Hu S, Yoshihara HA, Ward CS, Venkatesh HS, Wang C, Zhang X, Vigneron DB, Ronen SM. Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor. Cancer Res. 2010 Oct 01; 70(19):7400-10. PMID: 20858719; PMCID: PMC2948586.
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    88. Wilson DM, Keshari KR, Larson P, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7. PMID: 20478721; PMCID: PMC2885774.
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    89. Larson P, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB. Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med. 2010 Mar; 63(3):582-91. PMID: 20187172; PMCID: PMC2844437.
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    90. Hu S, Lustig M, Balakrishnan A, Larson P, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB. 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med. 2010 Feb; 63(2):312-21. PMID: 20017160; PMCID: PMC2829256.
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    91. Park I, Larson P, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ. Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol. 2010 Feb; 12(2):133-44. PMID: 20150380; PMCID: PMC2940577.
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    92. Keshari KR, Wilson DM, Chen AP, Bok R, Larson P, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J. Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc. 2009 Dec 09; 131(48):17591-6. PMID: 19860409; PMCID: PMC2796621.
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    93. Larson P, Lustig MS, Nishimura DG. Anisotropic field-of-view shapes for improved PROPELLER imaging. Magn Reson Imaging. 2009 May; 27(4):470-9. PMID: 18818039; PMCID: PMC2882965.
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    94. Larson P, Kerr AB, Chen AP, Lustig MS, Zierhut ML, Hu S, Cunningham CH, Pauly JM, Kurhanewicz J, Vigneron DB. Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging. J Magn Reson. 2008 Sep; 194(1):121-7. PMID: 18619875; PMCID: PMC3739981.
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    95. Peder E. Z. Larson, Paul T. Gurney, and Dwight G. Nishimura.IEEE Transactions on Medical Imaging. Anisotropic Field-of-views in radial imaging. 2008; 27(1):47-57.
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    96. Larson P, Conolly SM, Pauly JM, Nishimura DG. Using adiabatic inversion pulses for long-T2 suppression in ultrashort echo time (UTE) imaging. Magn Reson Med. 2007 Nov; 58(5):952-61. PMID: 17969119; PMCID: PMC2942769.
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    97. Larson P, Gurney PT, Nayak K, Gold GE, Pauly JM, Nishimura DG. Designing long-T2 suppression pulses for ultrashort echo time imaging. Magn Reson Med. 2006 Jul; 56(1):94-103. PMID: 16724304; PMCID: PMC2942755.
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