Peder Larson, PhD

Title(s)Associate Professor, Radiology
SchoolSchool of Medicine
Address1700 4th St
San Francisco CA 94158
Phone415-514-4876
ORCID ORCID Icon0000-0003-4183-3634 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBS2002Electrical Engineering & Mathematics
    Stanford UniversityMS2003Electrical Engineering
    Stanford UniversityPhD2007Electrical Engineering
    University of California, San FranciscoPostdoctoral Scholar2011Radiology and Biomedical Imaging
    Collapse Awards and Honors
    Medical Imaging with Deep Learning (MIDL)2021Best Long Oral Presentation "Understanding and Visualizing Generalization in Unets"
    Magnetic Resonance in Medicine2020Editor's Pick "Iterative motion-compensation reconstruction UTE for free-breathing pulmonary MRI"
    Magnetic Resonance in Medicine2020Editor's Pick "Extreme MRI: Large-scale volumetric dynamic imaging from continuous acquisitions"
    Academy for Radiology & Biomedical Imaging Research2019Distinguished Investigator
    Magnetic Resonance in Medicine2018Editors Pick "In vivo characterization of brain ultrashort-T2 components"
    American Cancer Society2018Research Scholar
    Magnetic Resonance in Medicine2010  - 2017Distinguished Reviewer
    International Society for Magnetic Resonance in Medicine2011Junior Fellow
    University of California, San Francisco2011Surbeck Scholar Award, 1st place
    University of California, San Francisco2010Surbeck Scholar Award, 1st place
    National Science Foundation Graduate Fellowship2003Honorable Mention

    Collapse Overview 
    Collapse Overview
    Peder Larson, PhD, is an Associate Professor in Residence and a Principal Investigator in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Larson's research program includes a range of imaging technology development targeting improved clinical outcomes, with projects on metabolic MRI, lung MRI, myelin imaging, PET/MRI, and radiation therapy planning:

    Metabolic imaging methods using hyperpolarized carbon-13 MRI
    This technology uses non-toxic, non-ionizing contrast agents to provide unique metabolism information, and is currently in clinical trials. Our team develops data acquisition, image reconstruction, and data analysis methods for this technology for a broad range of collaborators and applications. We are also leading new patient studies of this technology in renal cancers and heart disease.

    Lung MRI
    Conventional MRI performs very poorly in the lungs but our team has developed methods based on ultrashort echo time (UTE) MRI to provide high quality, high-resolution lung MRI. We are pursuing development of functional imaging biomarkers and translation onto clinical MRI scanners, with a focus on pediatric studies to reduce radiation dose compared to CT.

    Myelin MRI
    Our team has pioneered a new MRI approach for direct imaging of myelin based on ultrashort echo time (UTE) MRI. Other MRI methods provide indirect myelin measurements based measurements on nearby water. We are continuing to develop this technique as a quantitative imaging method, and translating into studies evaluating myelination in disease.

    PET/MRI
    Hybrid PET/MRI systems combine the functional information from PET tracers with the soft-tissue contrast from MRI. Our team is working on PET/MRI technology developments for motion management, quantitative imaging, and multi-modal data analysis with this modality.

    Radiation Therapy PLanning
    Applications of MRI in radiotherapy have increased significantly over the past decade due to the high level of soft tissue provided, often allowing for better visualization of tumors and organs at risk versus computed tomography (CT). Our team is working to develop specialized MR techniques to accurately estimate parameters used for radiotherapy dose calculation as a critical step towards MRI-only treatment planning.


    Dr. Larson is an active member of International Society for Magnetic Resonance in Medicine, the Institute for Electrical and Electronics Engineering, the UC Berkeley and UCSF Graduate Group in Bioengineering, the California Institute for Quantitative Biosciences, and the Bakar Institute for Computational Health Sciences.

    Collapse Research 
    Collapse Research Activities and Funding
    Hyperpolarized 13C Metabolic MRI for Noninvasive Monitoring of Kidney Injury
    NIH R21DK130002Jul 12, 2021 - Apr 30, 2023
    Role: Principal Investigator
    Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness
    NIH R01CA249909Jan 1, 2021 - Dec 31, 2025
    Role: Co-Principal Investigator
    Imaging Metabolism and Cellular Transport in Cancer
    American Cancer Society 131715-RSG-18-005-01-CCEJul 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    MRI methods for high resolution imaging of the lung
    NIH R01HL136965Apr 15, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Novel Ultrashort Echo Time Sequences for Brain MRI
    NIH R21NS089004Apr 1, 2016 - Mar 31, 2019
    Role: Principal Investigator
    Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and Metabolism
    NIH R01EB016741Sep 17, 2014 - May 31, 2019
    Role: Principal Investigator
    Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast
    NIH R00EB012064Sep 1, 2011 - Aug 31, 2015
    Role: Principal Investigator
    Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast
    NIH K99EB012064Sep 1, 2010 - Aug 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Collaboration Interests

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Quantitative analysis of repaired rabbit supraspinatus tendons (± channeling) using magnetic resonance imaging at 7 Tesla. Quantitative Imaging in Medicine and Surgery. 2021 Aug 1; 11(8):3460-3471. Guy Trudel, Samuel Duchesne-Bélanger, Justin Thomas, Gerd Melkus, Greg O. Cron, Peder E. Z. Larson, Mark Schweitzer, Adnan Sheikh, Hakim Louati, Odette Laneuville. .
      View in: Publisher Site   Mentions:
    2. Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13 C MR EPSI studies of liver tumors. Magn Reson Med. 2021 Jul 03. Lee PM, Chen HY, Gordon JW, Zhu Z, Larson PEZ, Dwork N, Van Criekinge M, Carvajal L, Ohliger MA, Wang ZJ, Xu D, Kurhanewicz J, Bok RA, Aggarwal R, Munster PN, Vigneron DB. PMID: 34216051.
      View in: PubMed   Mentions:    Fields:    
    3. Denoising of hyperpolarized 13 C MR images of the human brain using patch-based higher-order singular value decomposition. Magn Reson Med. 2021 Jun 25. Kim Y, Chen HY, Autry AW, Villanueva-Meyer J, Chang SM, Li Y, Larson PEZ, Brender JR, Krishna MC, Xu D, Vigneron DB, Gordon JW. PMID: 34173268.
      View in: PubMed   Mentions:    Fields:    
    4. Hyperpolarized Metabolic MRI-Acquisition, Reconstruction, and Analysis Methods. Metabolites. 2021 Jun 14; 11(6). Larson PEZ, Gordon JW. PMID: 34198574.
      View in: PubMed   Mentions:
    5. Metabolic imaging detects elevated glucose flux through the pentose phosphate pathway associated with TERT expression in low-grade gliomas. Neuro Oncol. 2021 Apr 17. Viswanath P, Batsios G, Ayyappan V, Taglang C, Gillespie AM, Larson PEZ, Luchman HA, Costello JF, Pieper RO, Ronen SM. PMID: 33864084.
      View in: PubMed   Mentions:    Fields:    
    6. Imaging 6-Phosphogluconolactonase Activity in Brain Tumors In Vivo Using Hyperpolarized d-[1-13C]gluconolactone. Front Oncol. 2021; 11:589570. Batsios G, Taglang C, Cao P, Gillespie AM, Najac C, Subramani E, Wilson DM, Flavell RR, Larson PEZ, Ronen SM, Viswanath P. PMID: 33937017.
      View in: PubMed   Mentions:
    7. Metabolic imaging with hyperpolarized 13 C pyruvate magnetic resonance imaging in patients with renal tumors-Initial experience. Cancer. 2021 Apr 12. Tang S, Meng MV, Slater JB, Gordon JW, Vigneron DB, Stohr BA, Larson PEZ, Wang ZJ. PMID: 33844280.
      View in: PubMed   Mentions:    Fields:    
    8. Optimizing trajectory ordering for fast radial ultra-short TE (UTE) acquisitions. J Magn Reson. 2021 Apr 02; 327:106977. Zhu X, Tan F, Johnson K, Larson P. PMID: 33873091.
      View in: PubMed   Mentions:    Fields:    
    9. TBMT-01. HYPERPOLARIZED d-[1-13C]GLUCONOLACTONE MONITORS TERT-INDUCED ELEVATION IN PENTOSE PHOSPHATE PATHWAY FLUX IN BRAIN TUMORS IN VIVO. Neuro-Oncology Advances. 2021 Mar 25; 3(Supplement_1):i20-i20. Georgios Batsios, Pavithra Viswanath, Celine Taglang, Robert Flavell, Joseph Costello, Russell O Pieper, Peder Larson, Sabrina Ronen. .
      View in: Publisher Site   Mentions:
    10. Utilizing the wavelet transform’s structure in compressed sensing. Signal, Image and Video Processing. 2021 Mar 9; 1-8. Nicholas Dwork, Daniel O’Connor, Corey A. Baron, Ethan M. I. Johnson, Adam B. Kerr, John M. Pauly, Peder E. Z. Larson. .
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    11. Di-chromatic interpolation of magnetic resonance metabolic images. MAGMA. 2021 Feb; 34(1):57-72. Dwork N, Gordon JW, Tang S, O'Connor D, Hansen ESS, Laustsen C, Larson PEZ. PMID: 33502669.
      View in: PubMed   Mentions:    Fields:    
    12. Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models. NMR Biomed. 2021 03; 34(3):e4467. Ahamed F, Van Criekinge M, Wang ZJ, Kurhanewicz J, Larson P, Sriram R. PMID: 33415771.
      View in: PubMed   Mentions:    Fields:    
    13. Non-invasive assessment of telomere maintenance mechanisms in brain tumors. Nat Commun. 2021 01 04; 12(1):92. Viswanath P, Batsios G, Mukherjee J, Gillespie AM, Larson PEZ, Luchman HA, Phillips JJ, Costello JF, Pieper RO, Ronen SM. PMID: 33397920.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Proceedings of Machine Learning Research. Understanding and Visualizing Generalization in UNets. 2021; (143):665-681. Abhejit Rajagopal, Vamshi Chowdary Madala, Thomas A Hope, Peder Larson. . View Publication.
    15. Predicting Generalization in Deep Learning via Local Measures of Distortion. arXiv. 2020. Abhejit Rajagopal, Vamshi C. Madala, Shivkumar Chandrasekaran, Peder E. Z. Larson. . View Publication.
    16. Fast variable density Poisson-disc sample generation with directional variation for compressed sensing in MRI. Magn Reson Imaging. 2021 04; 77:186-193. Dwork N, Baron CA, Johnson EMI, O'Connor D, Pauly JM, Larson PEZ. PMID: 33232767.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Proceedings of Machine Learning Research. Breaking Speed Limits with Simultaneous Ultra-Fast MRI Reconstruction and Tissue Segmentation. 2020; 121:94-110. Francesco Calivá, Andrew P. Leynes, Rutwik Shah, Upasana Upadhyay Bharadwaj, Sharmila Majumdar, Peder E. Z. Larson, Valentina Pedoia. View Publication.
    18. Technical Note: A methodology for improved accuracy in stopping power estimation using MRI and CT. Med Phys. 2021 Jan; 48(1):342-353. Scholey JE, Chandramohan D, Naren T, Liu W, Larson PEZ, Sudhyadhom A. PMID: 33107997.
      View in: PubMed   Mentions: 1     Fields:    
    19. NIMG-50. INITIAL EXPERIENCE: DETECTION OF ABERRANT HYPERPOLARIZED [1-13C]PYRUVATE METABOLISM IN PATIENTS WITH GBM PRIOR TO RESECTION. Neuro-Oncology. 2020 Nov 9; 22(Supplement_2):ii159-ii159. Adam Autry, Jeremy Gordon, Marisa LaFontaine, Hsin-Yu Chen, Javier Villanueva-Meyer, Susan Chang, Jennifer Clarke, Duan Xu, Janine Lupo, Peder Larson, Daniel Vigneron, Yan Li. .
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    20. 68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality. EJNMMI Phys. 2020 Aug 26; 7(1):54. Murthy V, Smith RL, Tao DH, Lawhn-Heath CA, Korenchan DE, Larson PEZ, Flavell RR, Hope TA. PMID: 32844310.
      View in: PubMed   Mentions:
    21. Slice profile effects on quantitative analysis of hyperpolarized pyruvate. NMR Biomed. 2020 10; 33(10):e4373. Walker CM, Gordon JW, Xu Z, Michel KA, Li L, Larson PEZ, Vigneron DB, Bankson JA. PMID: 32743881.
      View in: PubMed   Mentions:    Fields:    
    22. 55 Mn-based fiducial markers for rapid and automated RF coil localization for hyperpolarized 13 C MRI. Magn Reson Med. 2021 01; 85(1):518-530. Ohliger MA, Gordon JW, Carvajal L, Larson PEZ, Ou JJ, Agarwal S, Zhu Z, Vigneron DB, von Morze C. PMID: 32738073.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    23. A variable resolution approach for improved acquisition of hyperpolarized 13 C metabolic MRI. Magn Reson Med. 2020 12; 84(6):2943-2952. Gordon JW, Autry AW, Tang S, Graham JY, Bok RA, Zhu X, Villanueva-Meyer JE, Li Y, Ohilger MA, Abraham MR, Xu D, Vigneron DB, Larson PEZ. PMID: 32697867.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    24. MR-based Attenuation Correction for Brain PET Using 3D Cycle-Consistent Adversarial Network. IEEE Trans Radiat Plasma Med Sci. 2021 Mar; 5(2):185-192. Gong K, Yang J, Larson PEZ, Behr SC, Hope TA, Seo Y, Li Q. PMID: 33778235.
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    25. Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma. Neuroimage Clin. 2020; 27:102323. Autry AW, Gordon JW, Chen HY, LaFontaine M, Bok R, Van Criekinge M, Slater JB, Carvajal L, Villanueva-Meyer JE, Chang SM, Clarke JL, Lupo JM, Xu D, Larson PEZ, Vigneron DB, Li Y. PMID: 32623139.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. 3D Magnetic Resonance Spirometry. Sci Rep. 2020 06 15; 10(1):9649. Boucneau T, Fernandez B, Larson P, Darrasse L, Maître X. PMID: 32541799.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI. Magn Reson Med. 2020 12; 84(6):3351-3365. Chen HY, Autry AW, Brender JR, Kishimoto S, Krishna MC, Vareth M, Bok RA, Reed GD, Carvajal L, Gordon JW, van Criekinge M, Korenchan DE, Chen AP, Xu D, Li Y, Chang SM, Kurhanewicz J, Larson PEZ, Vigneron DB. PMID: 32501614.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized 13C MRI Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in a Prostate Cancer Mouse Model. Int J Radiat Oncol Biol Phys. 2020 08 01; 107(5):887-896. Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos Bs JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J. PMID: 32339646.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    29. In vivo detection of ?-glutamyl-transferase up-regulation in glioma using hyperpolarized ?-glutamyl-[1-13C]glycine. Sci Rep. 2020 04 10; 10(1):6244. Batsios G, Najac C, Cao P, Viswanath P, Subramani E, Saito Y, Gillespie AM, Yoshihara HAI, Larson P, Sando S, Ronen SM. PMID: 32277103.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    30. Extreme MRI: Large-scale volumetric dynamic imaging from continuous non-gated acquisitions. Magn Reson Med. 2020 10; 84(4):1763-1780. Ong F, Zhu X, Cheng JY, Johnson KM, Larson PEZ, Vasanawala SS, Lustig M. PMID: 32270547.
      View in: PubMed   Mentions: 1     Fields:    
    31. Hyperpolarized 13 C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco. NMR Biomed. 2021 May; 34(5):e4280. Crane JC, Gordon JW, Chen HY, Autry AW, Li Y, Olson MP, Kurhanewicz J, Vigneron DB, Larson PEZ, Xu D. PMID: 32189442.
      View in: PubMed   Mentions: 4     Fields:    
    32. Bone material analogues for PET/MRI phantoms. Med Phys. 2020 Jun; 47(5):2161-2170. Chandramohan D, Cao P, Han M, An H, Sunderland JJ, Kinahan PE, Laforest R, Hope TA, Larson PEZ. PMID: 32034945.
      View in: PubMed   Mentions: 1     Fields:    
    33. A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-13 C]pyruvate studies on a 3T clinical scanner. Magn Reson Med. 2020 09; 84(3):1113-1125. Tang S, Bok R, Qin H, Reed G, VanCriekinge M, Delos Santos R, Overall W, Santos J, Gordon J, Wang ZJ, Vigneron DB, Larson PEZ. PMID: 32086845.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    34. Fast Imaging for Hyperpolarized MR Metabolic Imaging. J Magn Reson Imaging. 2021 03; 53(3):686-702. Gordon JW, Chen HY, Dwork N, Tang S, Larson PEZ. PMID: 32039520.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    35. Simultaneous T1 and T2 mapping of hyperpolarized 13C compounds using the bSSFP sequence. J Magn Reson. 2020 03; 312:106691. Milshteyn E, Reed GD, Gordon JW, von Morze C, Cao P, Tang S, Leynes AP, Larson PEZ, Vigneron DB. PMID: 32058912.
      View in: PubMed   Mentions: 1     Fields:    
    36. Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging. Neuroimage. 2020 03; 208:116415. Guglielmetti C, Boucneau T, Cao P, Van der Linden A, Larson PEZ, Chaumeil MM. PMID: 31811900.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    37. CBMT-36. INITIAL EXPERIENCE WITH HYPERPOLARIZED [2-13C]PYRUVATE MR IMAGING IN PATIENTS WITH IDH-MUTANT GLIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi41-vi41. Adam Autry, Brian Chung, Hsin-Yu Chen, Jeremy Gordon, Marisa Lafontaine, Susan Chang, Javier Villanueva-Meyer, Peder Larson, Daniel Vigneron, Yan Li. .
      View in: Publisher Site   Mentions:
    38. NIMG-57. SERIAL HYPERPOLARIZED 13C PYRUVATE AND 1H METABOLIC IMAGING IN RECURRENT HIGH-GRADE GLIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi174-vi174. Javier Villanueva-Meyer, Adam Autry, Jeremy Gordon, Hsin-Yu Chen, Marisa Lafontaine, Susan Chang, Duan Xu, Peder Larson, Daniel Vigneron, Yan Li. .
      View in: Publisher Site   Mentions:
    39. CBMT-26. SERIAL CHARACTERIZATION OF HYPERPOLARIZED [1-13C]PYRUVATE METABOLISM IN PATIENTS WITH GLIOMA AND THE INFLUENCE OF BEVACIZUMAB. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi38-vi39. Adam Autry, Jeremy Gordon, Hsin-Yu Chen, Marisa Lafontaine, Javier Villanueva-Meyer, Susan Chang, Duan Xu, Peder Larson, Daniel Vigneron, Yan Li. .
      View in: Publisher Site   Mentions:
    40. CBMT-08. IN VIVO EVALUATION OF PENTOSE PHOSPHATE PATHWAY ACTIVITY IN ORTHOTOPIC GLIOMA USING HYPERPOLARIZED d-[1-13C]GLUCONOLACTONE. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi34-vi34. Georgios Batsios, Pavithra Viswanath, Peng Cao, Celine Taglang, Elavarasan Subramani, Robert Flavell, Peder Larson, Sabrina Ronen. .
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    41. CBMT-02. UP-REGULATION OF G-GLUTAMYL-TRANSFERASE CAN BE USED TO IMAGE GLIOBLASTOMA USING HYPERPOLARIZED G-GLUTAMYL-[1-13C]GLYCINE MRS. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi33-vi33. Georgios Batsios, Chloe Najac, Peng Cao, Pavithra Viswanath, Elavarasan Subramani, Yutaro Saito, Anne Marie Gillespie, Hikari Yoshihara, Peder Larson, Shinsuke Sando, Sabrina Ronen. .
      View in: Publisher Site   Mentions:
    42. Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study. Prostate Cancer Prostatic Dis. 2020 06; 23(2):269-276. Chen HY, Aggarwal R, Bok RA, Ohliger MA, Zhu Z, Lee P, Gordon JW, van Criekinge M, Carvajal L, Slater JB, Larson PEZ, Small EJ, Kurhanewicz J, Vigneron DB. PMID: 31685983.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    43. First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism. J Magn Reson. 2019 12; 309:106617. Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil MM, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB. PMID: 31648132.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsPHPublic Health
    44. Iterative motion-compensation reconstruction ultra-short TE (iMoCo UTE) for high-resolution free-breathing pulmonary MRI. Magn Reson Med. 2020 04; 83(4):1208-1221. Zhu X, Chan M, Lustig M, Johnson KM, Larson PEZ. PMID: 31565817.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    45. Technical Note: Simultaneous segmentation and relaxometry for MRI through multitask learning. Med Phys. 2019 Oct; 46(10):4610-4621. Cao P, Liu J, Tang S, Leynes AP, Lupo JM, Xu D, Larson PEZ. PMID: 31396973.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain. IEEE Trans Med Imaging. 2020 02; 39(2):320-327. Mammoli D, Gordon J, Autry A, Larson PEZ, Li Y, Chen HY, Chung B, Shin P, Van Criekinge M, Carvajal L, Slater JB, Bok R, Crane J, Xu D, Chang S, Vigneron DB. PMID: 31283497.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    47. Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging. Magn Reson Med. 2019 09; 82(3):959-972. Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR. PMID: 31050049.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    48. Hyperpolarized 13C MRI: State of the Art and Future Directions. Radiology. 2019 05; 291(2):273-284. Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB. PMID: 30835184.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    49. Effects of excitation angle strategy on quantitative analysis of hyperpolarized pyruvate. Magn Reson Med. 2019 06; 81(6):3754-3762. Walker CM, Fuentes D, Larson PEZ, Kundra V, Vigneron DB, Bankson JA. PMID: 30793791.
      View in: PubMed   Mentions: 5     Fields:    
    50. Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies. J Magn Reson. 2019 04; 301:73-79. Zhu Z, Zhu X, Ohliger MA, Tang S, Cao P, Carvajal L, Autry AW, Li Y, Kurhanewicz J, Chang S, Aggarwal R, Munster P, Xu D, Larson PEZ, Vigneron DB, Gordon JW. PMID: 30851668.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    51. Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging. NMR Biomed. 2019 03; 32(3):e4052. Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ. PMID: 30664305.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    52. Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients. Magn Reson Med. 2019 04; 81(4):2702-2709. Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB. PMID: 30375043.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    53. Dynamic diffusion-weighted hyperpolarized 13 C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport. Magn Reson Med. 2019 03; 81(3):2001-2010. Zhu X, Gordon JW, Bok RA, Kurhanewicz J, Larson PEZ. PMID: 30368893.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    54. Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients. NMR Biomed. 2018 11; 31(11):e3997. Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 30230646.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    55. A regional bolus tracking and real-time B1 calibration method for hyperpolarized 13 C MRI. Magn Reson Med. 2019 02; 81(2):839-851. Tang S, Milshteyn E, Reed G, Gordon J, Bok R, Zhu X, Zhu Z, Vigneron DB, Larson PEZ. PMID: 30277268.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    56. Developing an efficient phase-matched attenuation correction method for quiescent period PET in abdominal PET/MRI. Phys Med Biol. 2018 09 10; 63(18):185002. Yang J, Liu J, Wiesinger F, Menini A, Zhu X, Hope TA, Seo Y, Larson PEZ. PMID: 30106008.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    57. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers (Basel). 2018 Sep 05; 10(9). Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. PMID: 30189677.
      View in: PubMed   Mentions:
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    69. Zero TE-based pseudo-CT image conversion in the head and its application in PET/MR attenuation correction and MR-guided radiation therapy planning. Magn Reson Med. 2018 10; 80(4):1440-1451. Wiesinger F, Bylund M, Yang J, Kaushik S, Shanbhag D, Ahn S, Jonsson JH, Lundman JA, Hope T, Nyholm T, Larson P, Cozzini C. PMID: 29457287.
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    129. Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion. Magn Reson Med. 2014 Oct; 72(4):959-70. Shin PJ, Larson PE, Ohliger MA, Elad M, Pauly JM, Vigneron DB, Lustig M. PMID: 24248734.
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    130. Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain. Magn Reson Med. 2014 Jan; 71(1):19-25. Park I, Larson PE, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ. PMID: 24346964.
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    131. High resolution (13)C MRI with hyperpolarized urea: in vivo T(2) mapping and (15)N labeling effects. IEEE Trans Med Imaging. 2014 Feb; 33(2):362-71. Reed GD, von Morze C, Bok R, Koelsch BL, Van Criekinge M, Smith KJ, Hong Shang , Larson PE, Kurhanewicz J, Vigneron DB. PMID: 24235273.
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    132. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate. Sci Transl Med. 2013 Aug 14; 5(198):198ra108. Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA. PMID: 23946197.
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    133. Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates. J Magn Reson. 2013 Sep; 234:75-81. Xing Y, Reed GD, Pauly JM, Kerr AB, Larson PE. PMID: 23845910.
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    134. WE-C-116-02: High Resolution C-13 MRI with Hyperpolarized [C-13,N-15] Urea. Medical Physics. 2013 Jun 1; 40(6Part29):484-484. G Reed, C von Morze, R Bok, B Koelsch, K Smith, M van Criekinge, P Larson, J Kurhanewicz, D Vigneron. .
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    135. Signal scaling improves the signal-to-noise ratio of measurements with segmented 2D-selective radiofrequency excitations. Magn Reson Med. 2013 Dec; 70(6):1491-9. Finsterbusch J, Busch MG, Larson PE. PMID: 23440633.
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    136. Diffusion MR of hyperpolarized 13C molecules in solution. Analyst. 2013 Feb 21; 138(4):1011-4. Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J. PMID: 23304699.
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    137. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2014 Jan; 71(1):1-11. Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 23412881.
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    138. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013 Sep; 38(3):701-13. Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 23293097.
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    139. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4:2429. Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. PMID: 24019001.
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    140. Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2013 Jun; 31(5):635-42. Larson PE, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. PMID: 23260391.
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    141. Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2013 May; 31(4):490-6. Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 23107275.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    142. A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates. J Magn Reson. 2012 Dec; 225:71-80. Larson PE, Kerr AB, Swisher CL, Pauly JM, Vigneron DB. PMID: 23143011.
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    143. Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T. Magn Reson Imaging. 2013 Feb; 31(2):163-70. von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB. PMID: 22898680.
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    144. A first-in-human phase I imaging study using hyperpolarized 1 c-13 pyruvate (h-Py) in patients (pts) with localized prostate cancer (l-PCa). Journal of Clinical Oncology. 2012 May 20; 30(15_suppl):4660-4660. Andrea Lynne Harzstark, Vivian K. Weinberg, Krystyna Grycz, Ralph E. Hurd, Jan Henrik Ardenkjaer-Larsen, Jonathan Murray, Albert Chen, Marcus Ferrone, Ilwoo Park, Galen Reed, Pamela N. Munster, Eric Jay Small, Lucas E. Carvajal, Mark E. VanCriekinge, Peder E. Larson, Jose Chang, Robert A. Bok, Sarah J. Nelson, Daniel B. Vigneron, John V. Kurhanewicz. .
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    145. A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate. J Magn Reson. 2012 Apr; 217:41-7. Reed GD, Larson PE, Morze Cv, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. PMID: 22405760.
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    146. Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea. Magn Reson Imaging. 2012 Apr; 30(3):305-11. von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. PMID: 22169407.
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    147. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18606-11. Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. PMID: 22042839.
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    148. Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging. IEEE Trans Med Imaging. 2012 Feb; 31(2):265-75. Larson PE, Kerr AB, Reed GD, Hurd RE, Kurhanewicz J, Pauly JM, Vigneron DB. PMID: 22027366.
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    149. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging. 2011 Oct; 29(8):1035-40. Hu S, Zhu M, Yoshihara HA, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PE, Kurhanewicz J, Vigneron DB. PMID: 21855243.
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    150. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5. Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. PMID: 21769960.
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    151. 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab. 2011 Jul 06; 14(1):131-42. Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. PMID: 21723511.
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    152. Science to practice: Can inflammatory arthritis be monitored by using MR imaging with injected hyperpolarized 13C-pyruvate? Radiology. 2011 May; 259(2):309-10. Larson PE, Gold GE. PMID: 21502386.
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    153. Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate. J Magn Reson. 2011 Aug; 211(2):109-13. von Morze C, Reed G, Shin P, Larson PE, Hu S, Bok R, Vigneron DB. PMID: 21596601.
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    154. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011 Mar; 33(3):692-7. von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. PMID: 21563254.
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    155. Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2011 Jan; 208(1):171-7. Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. PMID: 21130012.
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    156. Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med. 2011 Mar; 65(3):610-9. Larson PE, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB. PMID: 20939089.
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    157. Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor. Cancer Res. 2010 Oct 01; 70(19):7400-10. Dafni H, Larson PE, Hu S, Yoshihara HA, Ward CS, Venkatesh HS, Wang C, Zhang X, Vigneron DB, Ronen SM. PMID: 20858719.
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    158. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7. Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J. PMID: 20478721.
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    159. Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med. 2010 Mar; 63(3):582-91. Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB. PMID: 20187172.
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    160. 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med. 2010 Feb; 63(2):312-21. Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB. PMID: 20017160.
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    161. Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol. 2010 Feb; 12(2):133-44. Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ. PMID: 20150380.
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    162. Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc. 2009 Dec 09; 131(48):17591-6. Keshari KR, Wilson DM, Chen AP, Bok R, Larson PE, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J. PMID: 19860409.
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    163. Anisotropic field-of-view shapes for improved PROPELLER imaging. Magn Reson Imaging. 2009 May; 27(4):470-9. Larson PE, Lustig MS, Nishimura DG. PMID: 18818039.
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    164. Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging. J Magn Reson. 2008 Sep; 194(1):121-7. Larson PE, Kerr AB, Chen AP, Lustig MS, Zierhut ML, Hu S, Cunningham CH, Pauly JM, Kurhanewicz J, Vigneron DB. PMID: 18619875.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    165. IEEE Transactions on Medical Imaging. Anisotropic Field-of-views in radial imaging. 2008; 27(1):47-57. Peder E. Z. Larson, Paul T. Gurney, and Dwight G. Nishimura. View Publication.
    166. Using adiabatic inversion pulses for long-T2 suppression in ultrashort echo time (UTE) imaging. Magn Reson Med. 2007 Nov; 58(5):952-61. Larson PE, Conolly SM, Pauly JM, Nishimura DG. PMID: 17969119.
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    167. Designing long-T2 suppression pulses for ultrashort echo time imaging. Magn Reson Med. 2006 Jul; 56(1):94-103. Larson PE, Gurney PT, Nayak K, Gold GE, Pauly JM, Nishimura DG. PMID: 16724304.
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