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Peder Larson, PhD

Title(s)Associate Professor, Radiology
SchoolSchool of Medicine
Phone415-514-4876
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBS2002Electrical Engineering & Mathematics
    Stanford UniversityMS2003Electrical Engineering
    Stanford UniversityPhD2007Electrical Engineering
    University of California, San FranciscoPostdoctoral Scholar2011Radiology and Biomedical Imaging
    Collapse Awards and Honors
    Magnetic Resonance in Medicine2018Editors Pick "In vivo characterization of brain ultrashort-T2 components"
    Magnetic Resonance in Medicine2010  - 2017Distinguished Reviewer
    International Society for Magnetic Resonance in Medicine2011Junior Fellow
    University of California, San Francisco2011Surbeck Scholar Award, 1st place
    University of California, San Francisco2010Surbeck Scholar Award, 1st place
    National Science Foundation Graduate Fellowship2003Honorable Mention

    Collapse Overview 
    Collapse Overview
    Peder Larson, PhD, is an Associate Professor in Residence and a Principal Investigator in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Larson's research program is primarily centered around developing new MRI scanning and reconstruction technology for improved clinical outcomes. These developments in his group are aimed at several applications:

    Metabolic imaging methods using hyperpolarized carbon-13 MRI
    This exciting new imaging modality in currently in Phase I and Phase II clinical trials for oncologic applications, and Dr. Larson's group is responsible for the scanning methods used in these trials. His group is also developing new methods, aimed to provide faster, more accurate and higher-resolution imaging as well as generate new types of information and image contrast.

    Semi-solid tissue MRI
    Conventional MRI does not detect semi-solid tissues, such as tendons and cortical bone, as well as components of myelin, ligaments, menisci, other connective tissues, and lung parenchyma. Dr. Larson’s groups is actively developing advanced semi-solid tissue MRI methods, and pursuing clinical applications in tendon, bone, myelin, and lung imaging.

    PET/MRI
    Recently introduced hybrid PET/MRI systems combine the exceptional soft-tissue contrast of MRI with the functional contrast of PET. Dr. Larson's group is developing MRI methods for these systems to provide improved quantification, image quality and SNR in a clinical setting.


    Dr. Larson is an active member of International Society for Magnetic Resonance in Medicine, the Institute for Electrical and Electronics Engineering, the UC Berkeley and UCSF Graduate Group in Bioengineering, and the California Institute for Quantitative Biosciences.


    Education and Training:
    • Bachelor of Science: Stanford University, California - Electrical Engineering and Mathematics
    • Masters of Science: Stanford University, California - Electrical Engineering
    • Doctor of Philosophy: Stanford University, California - Electrical Engineering
    • Postdoctoral Fellowship: University of California, San Francisco - Radiology and Biomedical Imaging

    Collapse Research 
    Collapse Research Activities and Funding
    Imaging Metabolism and Cellular Transport in Cancer
    American Cancer Society 131715-RSG-18-005-01-CCEJul 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    MRI methods for high resolution imaging of the lung
    NIH/NHLBI R01HL136965Apr 15, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Novel Ultrashort Echo Time Sequences for Brain MRI
    NIH/NINDS R21NS089004Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and Metabolism
    NIH/NIBIB R01EB016741Sep 17, 2014 - May 31, 2018
    Role: Principal Investigator
    Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast
    NIH/NIBIB R00EB012064Sep 1, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast
    NIH/NIBIB K99EB012064Sep 1, 2010 - Aug 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ. Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging. NMR Biomed. 2019 Jan 21; e4052. PMID: 30664305.
      View in: PubMed
    2. Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB. Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients. Magn Reson Med. 2018 Oct 30. PMID: 30375043.
      View in: PubMed
    3. Zhu X, Gordon JW, Bok RA, Kurhanewicz J, Larson PEZ. Dynamic diffusion-weighted hyperpolarized 13 C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport. Magn Reson Med. 2018 Oct 28. PMID: 30368893.
      View in: PubMed
    4. Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB. Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients. NMR Biomed. 2018 Nov; 31(11):e3997. PMID: 30230646.
      View in: PubMed
    5. Yang J, Liu J, Wiesinger F, Menini A, Zhu X, Hope TA, Seo Y, Larson PEZ. Developing an efficient phase-matched attenuation correction method for quiescent period PET in abdominal PET/MRI. Phys Med Biol. 2018 Sep 10; 63(18):185002. PMID: 30106008.
      View in: PubMed
    6. Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers (Basel). 2018 Sep 05; 10(9). PMID: 30189677.
      View in: PubMed
    7. Vareth M, Lupo J, Larson P, Nelson S. A comparison of coil combination strategies in 3D multi-channel MRSI reconstruction for patients with brain tumors. NMR Biomed. 2018 Nov; 31(11):e3929. PMID: 30168205.
      View in: PubMed
    8. Autry AW, Hashizume R, James CD, Larson PEZ, Vigneron DB, Park I. Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging. Contrast Media Mol Imaging. 2018; 2018:3215658. PMID: 30174560.
      View in: PubMed
    9. Coello E, Noeske R, Burns BL, Gordon JW, Jakary A, Menze B, Haase A, Larson PEZ, Li Y, Schulte RF. High-resolution echo-planar spectroscopic imaging at ultra-high field. NMR Biomed. 2018 Nov; 31(11):e3950. PMID: 30052300.
      View in: PubMed
    10. Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson PEZ. Spatio-Temporally Constrained Reconstruction for Hyperpolarized Carbon-13 MRI Using Kinetic Models. IEEE Trans Med Imaging. 2018 Dec; 37(12):2603-2612. PMID: 29994332.
      View in: PubMed
    11. Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration. Spine (Phila Pa 1976). 2018 05 15; 43(10):E592-E600. PMID: 28984733.
      View in: PubMed
    12. Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW. Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences. J Magn Reson Imaging. 2018 Dec; 48(6):1717-1720. PMID: 29761624.
      View in: PubMed
    13. Wei H, Cao P, Bischof A, Henry RG, Larson PEZ, Liu C. MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation. Neuroimage. 2018 07 15; 175:1-11. PMID: 29604452.
      View in: PubMed
    14. Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB. Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer. Magn Reson Med. 2018 Nov; 80(5):2062-2072. PMID: 29575178.
      View in: PubMed
    15. Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Larson PEZ, Vigneron DB. Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized 13C imaging using the bSSFP sequence. J Magn Reson. 2018 May; 290:46-59. PMID: 29567434.
      View in: PubMed
    16. Jiang W, Larson PEZ, Lustig M. Simultaneous auto-calibration and gradient delays estimation (SAGE) in non-Cartesian parallel MRI using low-rank constraints. Magn Reson Med. 2018 Nov; 80(5):2006-2016. PMID: 29524244.
      View in: PubMed
    17. von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME. In vivo hyperpolarization transfer in a clinical MRI scanner. Magn Reson Med. 2018 Aug; 80(2):480-487. PMID: 29488244.
      View in: PubMed
    18. Wiesinger F, Bylund M, Yang J, Kaushik S, Shanbhag D, Ahn S, Jonsson JH, Lundman JA, Hope T, Nyholm T, Larson P, Cozzini C. Zero TE-based pseudo-CT image conversion in the head and its application in PET/MR attenuation correction and MR-guided radiation therapy planning. Magn Reson Med. 2018 Oct; 80(4):1440-1451. PMID: 29457287.
      View in: PubMed
    19. Milshteyn E, von Morze C, Gordon JW, Zhu Z, Larson PEZ, Vigneron DB. High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate with spectral suppression of alanine and pyruvate-hydrate. Magn Reson Med. 2018 Sep; 80(3):1048-1060. PMID: 29451329.
      View in: PubMed
    20. Gordon JW, Hansen RB, Shin PJ, Feng Y, Vigneron DB, Larson PEZ. 3D hyperpolarized C-13 EPI with calibrationless parallel imaging. J Magn Reson. 2018 Apr; 289:92-99. PMID: 29476930.
      View in: PubMed
    21. Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ. Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies. Magn Reson Med. 2018 Sep; 80(3):864-873. PMID: 29322616.
      View in: PubMed
    22. Leynes AP, Larson PEZ.2018 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP):. Synthetic CT Generation Using MRI with Deep Learning: How Does the Selection of Input Images Affect the Resulting Synthetic CT?. 2018; 6692-6696.
      View Publication
    23. Boucneau T, Cao P, Tang S, Han M, Xu D, Henry RG, Larson PEZ. In vivo characterization of brain ultrashort-T2 components. Magn Reson Med. 2018 Aug; 80(2):726-735. PMID: 29194734.
      View in: PubMed
    24. Leynes AP, Yang J, Wiesinger F, Kaushik SS, Shanbhag DD, Seo Y, Hope TA, Larson PEZ. Zero-Echo-Time and Dixon Deep Pseudo-CT (ZeDD CT): Direct Generation of Pseudo-CT Images for Pelvic PET/MRI Attenuation Correction Using Deep Convolutional Neural Networks with Multiparametric MRI. J Nucl Med. 2018 May; 59(5):852-858. PMID: 29084824.
      View in: PubMed
    25. Cao P, Zhu X, Tang S, Leynes A, Jakary A, Larson PEZ. Shuffled magnetization-prepared multicontrast rapid gradient-echo imaging. Magn Reson Med. 2018 Jan; 79(1):62-70. PMID: 29080236.
      View in: PubMed
    26. Li Y, Bian W, Larson P, Crane JC, Parvathaneni P, Nagarajan S, Nelson SJ. Reliable and Reproducible GABA Measurements Using Automated Spectral Prescription at Ultra-High Field. Front Hum Neurosci. 2017; 11:506. PMID: 29118697.
      View in: PubMed
    27. Chiew M, Jiang W, Burns B, Larson P, Steel A, Jezzard P, Albert Thomas M, Emir UE. Density-weighted concentric rings k-space trajectory for 1 H magnetic resonance spectroscopic imaging at 7 T. NMR Biomed. 2018 Jan; 31(1). PMID: 29044762.
      View in: PubMed
    28. Jiang W, Ong F, Johnson KM, Nagle SK, Hope TA, Lustig M, Larson PEZ. Motion robust high resolution 3D free-breathing pulmonary MRI using dynamic 3D image self-navigator. Magn Reson Med. 2018 Jun; 79(6):2954-2967. PMID: 29023975.
      View in: PubMed
    29. Yang J, Wiesinger F, Kaushik S, Shanbhag D, Hope TA, Larson PEZ, Seo Y. Evaluation of Sinus/Edge-Corrected Zero-Echo-Time-Based Attenuation Correction in Brain PET/MRI. J Nucl Med. 2017 11; 58(11):1873-1879. PMID: 28473594.
      View in: PubMed
    30. Korenchan DE, Taglang C, von Morze C, Blecha JE, Gordon JW, Sriram R, Larson PEZ, Vigneron DB, VanBrocklin HF, Kurhanewicz J, Wilson DM, Flavell RR. Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging. Analyst. 2017 May 02; 142(9):1429-1433. PMID: 28322385.
      View in: PubMed
    31. Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB. Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. Cancer Res. 2017 06 15; 77(12):3207-3216. PMID: 28428273.
      View in: PubMed
    32. Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA. Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver. J Magn Reson Imaging. 2018 01; 47(1):141-151. PMID: 28419644.
      View in: PubMed
    33. Ehman EC, Johnson GB, Villanueva-Meyer JE, Cha S, Leynes AP, Larson PEZ, Hope TA. PET/MRI: Where might it replace PET/CT? J Magn Reson Imaging. 2017 11; 46(5):1247-1262. PMID: 28370695.
      View in: PubMed
    34. Leynes AP, Yang J, Shanbhag DD, Kaushik SS, Seo Y, Hope TA, Wiesinger F, Larson PE. Hybrid ZTE/Dixon MR-based attenuation correction for quantitative uptake estimation of pelvic lesions in PET/MRI. Med Phys. 2017 Mar; 44(3):902-913. PMID: 28112410.
      View in: PubMed
    35. Yang J, Jian Y, Jenkins N, Behr SC, Hope TA, Larson PEZ, Vigneron D, Seo Y. Quantitative Evaluation of Atlas-based Attenuation Correction for Brain PET in an Integrated Time-of-Flight PET/MR Imaging System. Radiology. 2017 07; 284(1):169-179. PMID: 28234560.
      View in: PubMed
    36. Trudel G, Melkus G, Cron GO, Louati H, Sheikh A, Larson PEZ, Schweitzer M, Lapner P, Uhthoff HK, Laneuville O. Imaging of the rabbit supraspinatus enthesis at 7 Tesla: a 4-week time course after repair surgery and effect of channeling. J Magn Reson Imaging. 2017 08; 46(2):461-467. PMID: 28152242.
      View in: PubMed
    37. Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB. Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques. Magn Reson Imaging. 2017 05; 38:152-162. PMID: 28077268.
      View in: PubMed
    38. Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone. Magn Reson Med. 2017 01; 77(1):65-73. PMID: 27859575.
      View in: PubMed
    39. Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PEZ, Pauly JM, Vigneron DB. Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses. Magn Reson Med. 2017 09; 78(3):963-975. PMID: 27770458.
      View in: PubMed
    40. Gordon JW, Milshteyn E, Marco-Rius I, Ohliger M, Vigneron DB, Larson PEZ. Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects. Magn Reson Med. 2017 09; 78(3):1087-1092. PMID: 27735082.
      View in: PubMed
    41. Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PEZ, Kurhanewicz J. Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR. J Magn Reson. 2016 09; 270:115-123. PMID: 27434780.
      View in: PubMed
    42. Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PEZ, Bok R, Chen HY, Kurhanewicz J, Vigneron D. Combining hyperpolarized 13 C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism. Magn Reson Med. 2017 06; 77(6):2356-2363. PMID: 27298073.
      View in: PubMed
    43. Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135. PMID: 27570835.
      View in: PubMed
    44. Maidens J, Gordon JW, Arcak M, Larson PE. Optimizing Flip Angles for Metabolic Rate Estimation in Hyperpolarized Carbon-13 MRI. IEEE Trans Med Imaging. 2016 11; 35(11):2403-2412. PMID: 27249825.
      View in: PubMed
    45. Cao P, Shin PJ, Park I, Najac C, Marco-Rius I, Vigneron DB, Nelson SJ, Ronen SM, Larson PE. Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing. Magn Reson Med. 2016 08; 76(2):369-79. PMID: 27228088.
      View in: PubMed
    46. von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB. Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver. Magn Reson Med. 2017 04; 77(4):1429-1437. PMID: 27098724.
      View in: PubMed
    47. Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB. Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies. Magn Reson Med. 2017 04; 77(4):1419-1428. PMID: 27017966.
      View in: PubMed
    48. Gordon JW, Vigneron DB, Larson PE. Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized 13 C imaging. Magn Reson Med. 2017 02; 77(2):826-832. PMID: 26898849.
      View in: PubMed
    49. Larson PE, Han M, Krug R, Jakary A, Nelson SJ, Vigneron DB, Henry RG, McKinnon G, Kelley DA. Ultrashort echo time and zero echo time MRI at 7T. MAGMA. 2016 Jun; 29(3):359-70. PMID: 26702940; PMCID: PMC4892974 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    50. Shang H, Larson PEZ, Kerr A, Reed G, Sukumar S, Elkhaled A, Gordon JW, Ohliger MA, Pauly JM, Lustig M, Vigneron DB. Multiband RF pulses with improved performance via convex optimization. J Magn Reson. 2016 Jan; 262:81-90. PMID: 26754063.
      View in: PubMed
    51. Cao P, Zhang X, Park I, Najac C, Nelson SJ, Ronen S, Larson PE. 1 H-13 C independently tuned radiofrequency surface coil applied for in vivo hyperpolarized MRI. Magn Reson Med. 2016 11; 76(5):1612-1620. PMID: 26597845.
      View in: PubMed
    52. Feng Y, Gordon JW, Shin PJ, von Morze C, Lustig M, Larson PEZ, Ohliger MA, Carvajal L, Tropp J, Pauly JM, Vigneron DB. Development and testing of hyperpolarized (13)C MR calibrationless parallel imaging. J Magn Reson. 2016 Jan; 262:1-7. PMID: 26679288; PMCID: PMC4864033 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    53. Xie L, Layton AT, Wang N, Larson PE, Zhang JL, Lee VS, Liu C, Johnson GA. Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function. Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F174-82. PMID: 26447222; PMCID: PMC4719043 [Available on 01/15/17].
      View in: PubMed, PubMed Central
    54. Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM. Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb). 2015 Sep 25; 51(74):14119-22. PMID: 26257040; PMCID: PMC4854286.
      View in: PubMed, PubMed Central
    55. Han M, Rieke V, Scott SJ, Ozhinsky E, Salgaonkar VA, Jones PD, Larson PE, Diederich CJ, Krug R. Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI. Magn Reson Med. 2015 Dec; 74(6):1548-55. PMID: 26390357; PMCID: PMC4715675 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    56. Burris NS, Johnson KM, Larson PE, Hope MD, Nagle SK, Behr SC, Hope TA. Detection of Small Pulmonary Nodules with Ultrashort Echo Time Sequences in Oncology Patients by Using a PET/MR System. Radiology. 2016 Jan; 278(1):239-46. PMID: 26133050; PMCID: PMC4699498 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    57. Leon Swisher C, Koelsch B, Sukumar S, Sriram R, Santos RD, Wang ZJ, Kurhanewicz J, Vigneron D, Larson P. Dynamic UltraFast 2D EXchange SpectroscopY (UF-EXSY) of hyperpolarized substrates. J Magn Reson. 2015 Aug; 257:102-9. PMID: 26117655; PMCID: PMC4515769.
      View in: PubMed, PubMed Central
    58. Shang H, Skloss T, von Morze C, Carvajal L, Van Criekinge M, Milshteyn E, Larson PE, Hurd RE, Vigneron DB. Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples. Magn Reson Med. 2016 Feb; 75(2):917-22. PMID: 25765516; PMCID: PMC4567531 [Available on 02/01/17].
      View in: PubMed, PubMed Central
    59. Jiang W, Lustig M, Larson PE. Concentric rings K-space trajectory for hyperpolarized (13)C MR spectroscopic imaging. Magn Reson Med. 2016 Jan; 75(1):19-31. PMID: 25533653; PMCID: PMC4476971 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    60. Bian W, Banerjee S, Kelly DA, Hess CP, Larson PE, Chang SM, Nelson SJ, Lupo JM. Simultaneous imaging of radiation-induced cerebral microbleeds, arteries and veins, using a multiple gradient echo sequence at 7 Tesla. J Magn Reson Imaging. 2015 Aug; 42(2):269-79. PMID: 25471321; PMCID: PMC4876721.
      View in: PubMed, PubMed Central
    61. Shin PJ, Larson PE, Uecker M, Reed GD, Kerr AB, Tropp J, Ohliger MA, Nelson SJ, Pauly JM, Lustig M, Vigneron DB. Chemical shift separation with controlled aliasing for hyperpolarized (13) C metabolic imaging. Magn Reson Med. 2015 Oct; 74(4):978-89. PMID: 25298086; PMCID: PMC4390401 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    62. Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PEZ. Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites. Magn Reson Med. 2015 Sep; 74(3):622-633. PMID: 25213126; PMCID: PMC4362805.
      View in: PubMed, PubMed Central
    63. Keshari KR, Wilson DM, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ. Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes. 2015 Feb; 64(2):344-52. PMID: 25187363; PMCID: PMC4303960.
      View in: PubMed, PubMed Central
    64. Wang YX, Lo GG, Yuan J, Larson PE, Zhang X. Magnetic resonance imaging for lung cancer screen. J Thorac Dis. 2014 Sep; 6(9):1340-8. PMID: 25276380; PMCID: PMC4178109.
      View in: PubMed, PubMed Central
    65. Tang S, Jiang W, Chen HY, Bok R, Vigneron DB, Larson PE. A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging. Magn Reson Med. 2015 Aug; 74(2):506-12. PMID: 25154961; PMCID: PMC4336852.
      View in: PubMed, PubMed Central
    66. Li Y, Larson P, Chen AP, Lupo JM, Ozhinsky E, Kelley D, Chang SM, Nelson SJ. Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels. J Magn Reson Imaging. 2015 May; 41(5):1332-41. PMID: 24935758; PMCID: PMC4269580.
      View in: PubMed, PubMed Central
    67. Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res. 2014 Aug 15; 74(16):4247-57. PMID: 24876103; PMCID: PMC4134724.
      View in: PubMed, PubMed Central
    68. Han M, Larson PE, Liu J, Krug R. Depiction of achilles tendon microstructure in vivo using high-resolution 3-dimensional ultrashort echo-time magnetic resonance imaging at 7 T. Invest Radiol. 2014 May; 49(5):339-45. PMID: 24500089; PMCID: PMC4143127.
      View in: PubMed, PubMed Central
    69. Bahrami N, Swisher CL, Von Morze C, Vigneron DB, Larson PE. Kinetic and perfusion modeling of hyperpolarized (13)C pyruvate and urea in cancer with arbitrary RF flip angles. Quant Imaging Med Surg. 2014 Feb; 4(1):24-32. PMID: 24649432; PMCID: PMC3947982.
      View in: PubMed, PubMed Central
    70. Shin PJ, Larson PE, Ohliger MA, Elad M, Pauly JM, Vigneron DB, Lustig M. Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion. Magn Reson Med. 2014 Oct; 72(4):959-70. PMID: 24248734; PMCID: PMC4025999.
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    71. Park I, Larson PE, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ. Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain. Magn Reson Med. 2014 Jan; 71(1):19-25. PMID: 24346964; PMCID: PMC4041734.
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    72. Reed GD, von Morze C, Bok R, Koelsch BL, Van Criekinge M, Smith KJ, Larson PE, Kurhanewicz J, Vigneron DB. High resolution (13)C MRI with hyperpolarized urea: in vivo T(2) mapping and (15)N labeling effects. IEEE Trans Med Imaging. 2014 Feb; 33(2):362-71. PMID: 24235273; PMCID: PMC4011557.
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    73. Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate. Sci Transl Med. 2013 Aug 14; 5(198):198ra108. PMID: 23946197.
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    74. Xing Y, Reed GD, Pauly JM, Kerr AB, Larson PE. Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates. J Magn Reson. 2013 Sep; 234:75-81. PMID: 23845910.
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    75. Finsterbusch J, Busch MG, Larson PE. Signal scaling improves the signal-to-noise ratio of measurements with segmented 2D-selective radiofrequency excitations. Magn Reson Med. 2013 Dec; 70(6):1491-9. PMID: 23440633; PMCID: PMC4987130.
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    76. Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J. Diffusion MR of hyperpolarized 13C molecules in solution. Analyst. 2013 Feb 21; 138(4):1011-4. PMID: 23304699; PMCID: PMC3568999.
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    77. Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2014 Jan; 71(1):1-11. PMID: 23412881; PMCID: PMC3659200.
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    78. Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013 Sep; 38(3):701-13. PMID: 23293097; PMCID: PMC3759833.
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    79. Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4:2429. PMID: 24019001; PMCID: PMC3908661.
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    80. Larson PE, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2013 Jun; 31(5):635-42. PMID: 23260391; PMCID: PMC3626756.
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    81. Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2013 May; 31(4):490-6. PMID: 23107275; PMCID: PMC3625683.
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    82. Larson PE, Kerr AB, Swisher CL, Pauly JM, Vigneron DB. A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates. J Magn Reson. 2012 Dec; 225:71-80. PMID: 23143011; PMCID: PMC3531583.
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    83. von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB. Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T. Magn Reson Imaging. 2013 Feb; 31(2):163-70. PMID: 22898680; PMCID: PMC3651030.
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    84. Reed GD, Larson PE, Morze Cv, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate. J Magn Reson. 2012 Apr; 217:41-7. PMID: 22405760; PMCID: PMC3326401.
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    85. von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea. Magn Reson Imaging. 2012 Apr; 30(3):305-11. PMID: 22169407; PMCID: PMC3393100.
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    86. Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18606-11. PMID: 22042839; PMCID: PMC3219134.
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    87. Larson PE, Kerr AB, Reed GD, Hurd RE, Kurhanewicz J, Pauly JM, Vigneron DB. Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging. IEEE Trans Med Imaging. 2012 Feb; 31(2):265-75. PMID: 22027366; PMCID: PMC3274664.
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    88. Hu S, Zhu M, Yoshihara HA, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PE, Kurhanewicz J, Vigneron DB. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging. 2011 Oct; 29(8):1035-40. PMID: 21855243; PMCID: PMC3172390.
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    89. Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5. PMID: 21769960; PMCID: PMC3197976.
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    90. Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab. 2011 Jul 06; 14(1):131-42. PMID: 21723511; PMCID: PMC3858338.
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    91. Larson PE, Gold GE. Science to practice: Can inflammatory arthritis be monitored by using MR imaging with injected hyperpolarized 13C-pyruvate? Radiology. 2011 May; 259(2):309-10. PMID: 21502386.
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    92. von Morze C, Reed G, Shin P, Larson PE, Hu S, Bok R, Vigneron DB. Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate. J Magn Reson. 2011 Aug; 211(2):109-13. PMID: 21596601; PMCID: PMC3143308.
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    93. von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011 Mar; 33(3):692-7. PMID: 21563254; PMCID: PMC3566235.
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    94. Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2011 Jan; 208(1):171-7. PMID: 21130012; PMCID: PMC3387549.
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    95. Larson PE, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB. Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med. 2011 Mar; 65(3):610-9. PMID: 20939089; PMCID: PMC3021589.
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    96. Dafni H, Larson PE, Hu S, Yoshihara HA, Ward CS, Venkatesh HS, Wang C, Zhang X, Vigneron DB, Ronen SM. Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor. Cancer Res. 2010 Oct 01; 70(19):7400-10. PMID: 20858719; PMCID: PMC2948586.
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    97. Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7. PMID: 20478721; PMCID: PMC2885774.
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    98. Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB. Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med. 2010 Mar; 63(3):582-91. PMID: 20187172; PMCID: PMC2844437.
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    99. Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB. 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med. 2010 Feb; 63(2):312-21. PMID: 20017160; PMCID: PMC2829256.
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    100. Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ. Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol. 2010 Feb; 12(2):133-44. PMID: 20150380; PMCID: PMC2940577.
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    101. Keshari KR, Wilson DM, Chen AP, Bok R, Larson PE, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J. Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc. 2009 Dec 09; 131(48):17591-6. PMID: 19860409; PMCID: PMC2796621.
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    102. Larson PE, Lustig MS, Nishimura DG. Anisotropic field-of-view shapes for improved PROPELLER imaging. Magn Reson Imaging. 2009 May; 27(4):470-9. PMID: 18818039; PMCID: PMC2882965.
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    103. Larson PE, Kerr AB, Chen AP, Lustig MS, Zierhut ML, Hu S, Cunningham CH, Pauly JM, Kurhanewicz J, Vigneron DB. Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging. J Magn Reson. 2008 Sep; 194(1):121-7. PMID: 18619875; PMCID: PMC3739981.
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    104. Peder E. Z. Larson, Paul T. Gurney, and Dwight G. Nishimura.IEEE Transactions on Medical Imaging. Anisotropic Field-of-views in radial imaging. 2008; 27(1):47-57.
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    105. Larson PE, Conolly SM, Pauly JM, Nishimura DG. Using adiabatic inversion pulses for long-T2 suppression in ultrashort echo time (UTE) imaging. Magn Reson Med. 2007 Nov; 58(5):952-61. PMID: 17969119; PMCID: PMC2942769.
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    106. Larson PE, Gurney PT, Nayak K, Gold GE, Pauly JM, Nishimura DG. Designing long-T2 suppression pulses for ultrashort echo time imaging. Magn Reson Med. 2006 Jul; 56(1):94-103. PMID: 16724304; PMCID: PMC2942755.
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