Loading...

Peter Haggie, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-8985
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Studies Graduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Host-Targeted Homoserine Lactone Inhibitor as Adjunctive Antipseudomonal Therapy
    NIH/NIAID R21AI111634Mar 1, 2014 - Feb 29, 2016
    Role: Principal Investigator
    Novel Small-Molecule Therapies for CF
    NIH/NIDDK P30DK072517Aug 7, 2010 - May 31, 2020
    Role: Co-Investigator
    LIVE-CELL IMAGING OF CFTR OLIGOMERIZATION, TRAFFICKING AND INTERACTIONS
    NIH/NIDDK R01DK081355Aug 1, 2008 - May 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation. J Cyst Fibros. 2020 Jul 14. Phuan PW, Haggie PM, Tan JA, Rivera AA, Finkbeiner WE, Nielson DW, Thomas MM, Janahi IA, Verkman AS. PMID: 32674984.
      View in: PubMed   Mentions:    Fields:    
    2. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. J Clin Invest. 2020 Apr 01; 130(4):2041-2053. Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. PMID: 31961827.
      View in: PubMed   Mentions:    Fields:    
    3. Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR. J Cyst Fibros. 2020 Mar; 19 Suppl 1:S25-S32. Bose SJ, Krainer G, Ng DRS, Schenkel M, Shishido H, Yoon JS, Haggie PM, Schlierf M, Sheppard DN, Skach WR. PMID: 31902693.
      View in: PubMed   Mentions:    Fields:    
    4. Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. Sci Rep. 2019 11 27; 9(1):17640. Phuan PW, Tan JA, Rivera AA, Zlock L, Nielson DW, Finkbeiner WE, Haggie PM, Verkman AS. PMID: 31776420.
      View in: PubMed   Mentions: 1     Fields:    
    5. 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J Med Chem. 2019 09 12; 62(17):8330-8337. Lee S, Cil O, Haggie PM, Verkman AS. PMID: 31389695.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin). Bioorg Med Chem Lett. 2019 08 15; 29(16):2119-2123. Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ. PMID: 31281021.
      View in: PubMed   Mentions:    Fields:    
    7. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI Insight. 2018 07 26; 3(14). Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. PMID: 30046015.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators. J Cyst Fibros. 2018 09; 17(5):595-606. Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS. PMID: 29903467.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. ?F508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter. SLAS Discov. 2018 09; 23(8):823-831. Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. PMID: 29533733.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product. J Biol Chem. 2017 01 20; 292(3):771-785. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. PMID: 27895116.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. J Am Soc Nephrol. 2016 Dec; 27(12):3706-3714. Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. PMID: 27153921.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    12. Su1580 A Small-Molecule CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation. Gastroenterology. 2016 Apr 1; 150(4):s532. Onur Cil, Puay-Wah Phuan, Sujin Lee, Joseph-Anthony T. Tan, Peter Haggie, Marc H. Levin, Liang Sun, Jay Thiagarajah, Tonghui Ma, Alan S. Verkman. .
      View in: Publisher Site   Mentions:
    13. Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB J. 2016 06; 30(6):2187-97. Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS. PMID: 26932931.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    14. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):317-327. Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. PMID: 27127798.
      View in: PubMed   Mentions: 14     Fields:    
    15. X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. PLoS Pathog. 2013; 9(8):e1003576. Valentine CD, Anderson MO, Papa FR, Haggie PM. PMID: 23990788.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    16. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cell Microbiol. 2014 Jan; 16(1):1-14. Valentine CD, Zhang H, Phuan PW, Nguyen J, Verkman AS, Haggie PM. PMID: 23910799.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Reduced PDZ interactions of rescued ?F508CFTR increases its cell surface mobility. J Biol Chem. 2012 Dec 21; 287(52):43630-8. Valentine CD, Lukacs GL, Verkman AS, Haggie PM. PMID: 23115232.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Protein trafficking rates assessed by quantum dot quenching with bromocresol green. Traffic. 2012 Jan; 13(1):25-9. Valentine CD, Verkman AS, Haggie PM. PMID: 21951589.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    19. Confinement of ß(1)- and ß(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae. Mol Biol Cell. 2011 Aug 15; 22(16):2970-82. Valentine CD, Haggie PM. PMID: 21680711.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    20. Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L859-67. Haggie PM, Verkman AS. PMID: 19329540.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. QUANTUM DOT SINGLE MOLECULE TRACKING REVEALS A WIDE RANGE OF DIFFUSIVE MOTIONS OF MEMBRANE TRANSPORT PROTEINS. Proc SPIE Int Soc Opt Eng. 2009 Mar 03; 7489. Crane JM, Haggie PM, Verkman AS. PMID: 24386532.
      View in: PubMed   Mentions:
    22. Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. J Biol Chem. 2009 Mar 20; 284(12):7681-6. Haggie PM, Verkman AS. PMID: 19136560.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    23. Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging. J Biol Chem. 2008 Aug 29; 283(35):23510-3. Haggie PM, Verkman AS. PMID: 18617526.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    24. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. J Biol Chem. 2007 Oct 26; 282(43):31422-8. Haggie PM, Verkman AS. PMID: 17724021.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    25. Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels. Biophys J. 2007 Aug 01; 93(3):1079-88. Jin S, Haggie PM, Verkman AS. PMID: 17483157.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    26. Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Mol Biol Cell. 2006 Dec; 17(12):4937-45. Haggie PM, Kim JK, Lukacs GL, Verkman AS. PMID: 16987954.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    27. A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging. Biochem J. 2005 Sep 15; 390(Pt 3):787-90. Botchway SW, Barba I, Jordan R, Harmston R, Haggie PM, Williams SP, Fulton AM, Parker AW, Brindle KM. PMID: 15946123.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    28. GFP Sensors. Advanced Concepts in Fluorescence Sensing. 2005 Jan 1; 21-40. Peter M. Haggie, A.S. Verkman. .
      View in: Publisher Site   Mentions:
    29. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 2005 Mar; 19(3):431-3. Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. PMID: 15596485.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    30. In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. J Neurosci. 2004 Sep 15; 24(37):8049-56. Binder DK, Papadopoulos MC, Haggie PM, Verkman AS. PMID: 15371505.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    31. A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. FASEB J. 2004 May; 18(7):875-7. Thiagarajah JR, Song Y, Haggie PM, Verkman AS. PMID: 15001557.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    32. Application of Green Fluorescent Protein-Based Chloride Indicators for Drug Discovery by High-Throughput Screening. Reviews in Fluorescence 2004. 2004 Jan 1; 85-98. A. S. Verkman, Peter M. Haggie, Luis J. V. Galietta. .
      View in: Publisher Site   Mentions:
    33. Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif. J Biol Chem. 2004 Feb 13; 279(7):5494-500. Haggie PM, Stanton BA, Verkman AS. PMID: 14660592.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    34. Diffusion of tricarboxylic acid cycle enzymes in the mitochondrial matrix in vivo. Evidence for restricted mobility of a multienzyme complex. J Biol Chem. 2002 Oct 25; 277(43):40782-8. Haggie PM, Verkman AS. PMID: 12198136.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    35. Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras. J Biol Chem. 2002 May 10; 277(19):16419-25. Haggie PM, Stanton BA, Verkman AS. PMID: 11877404.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    36. Green fluorescent protein-based halide indicators with improved chloride and iodide affinities. FEBS Lett. 2001 Jun 22; 499(3):220-4. Galietta LJ, Haggie PM, Verkman AS. PMID: 11423120.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    37. Diffusion in the endoplasmic reticulum of an aquaporin-2 mutant causing human nephrogenic diabetes insipidus. J Biol Chem. 2001 Jun 15; 276(24):21331-6. Levin MH, Haggie PM, Vetrivel L, Verkman AS. PMID: 11297561.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Diffusion Measurements by Fluorescence Recovery After Photobleaching. Methods in Cellular Imaging. 2001 Jan 1; 112-127. Alan S. Verkman, Lakshmanan Vetrivel, Peter Haggie. .
      View in: Publisher Site   Mentions:
    39. Mechanism and cellular applications of a green fluorescent protein-based halide sensor. J Biol Chem. 2000 Mar 03; 275(9):6047-50. Jayaraman S, Haggie P, Wachter RM, Remington SJ, Verkman AS. PMID: 10692389.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    40. Size-dependent DNA mobility in cytoplasm and nucleus. J Biol Chem. 2000 Jan 21; 275(3):1625-9. Lukacs GL, Haggie P, Seksek O, Lechardeur D, Freedman N, Verkman AS. PMID: 10636854.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansCells
    41. Probing The Cell Interior With NMR Spectroscopy. Technological and Medical Implications of Metabolic Control Analysis. 2000 Jan 1; 191-198. Kevin M. Brindle, Peter M. Haggie. .
      View in: Publisher Site   Mentions:
    42. Mitochondrial citrate synthase is immobilized in vivo. J Biol Chem. 1999 Feb 12; 274(7):3941-5. Haggie PM, Brindle KM. PMID: 9933583.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    43. 19F NMR measurements of the rotational mobility of proteins in vivo. Biophys J. 1997 Jan; 72(1):490-8. Williams SP, Haggie PM, Brindle KM. PMID: 8994636.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    Peter's Networks
    Concepts (252)
    Derived automatically from this person's publications.
    _
    Co-Authors (11)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _