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Philippe Depeille, PhD

Title(s)Specialist, Anatomy
SchoolSchool of Medicine
Phone415-476-4322
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gbenedio OM, Bonnans C, Grun D, Wang CY, Hatch AJ, Mahoney MR, Barras D, Matli M, Miao Y, Garcia KC, Tejpar S, Delorenzi M, Venook AP, Nixon AB, Warren RS, Roose JP, Depeille P. RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. JCI Insight. 2019 Jun 25; 5. PMID: 31237864.
      View in: PubMed
    2. Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017 05 08; 31(5):685-696.e6. PMID: 28486107.
      View in: PubMed
    3. Jeroen Roose, Philippe Depeille, Robert S. Warren. Suppressive signals in colorectal cancer: RasGRP1 a new marker for anti-EGFR therapy?. Journal of Clinical Oncology. 2016 Feb 1; 34(4_suppl):625-625.
      View in: Publisher Site
    4. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 06; 36(1):142-52. PMID: 26740656.
      View in: PubMed
    5. Depeille P, Warren RS, Roose JP. Unexpected insights for anti-EGFR cancer therapy. Oncotarget. 2015 Aug 07; 6(22):18746-7. PMID: 26300054.
      View in: PubMed
    6. Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol. 2015 Jun; 17(6):804-15. PMID: 26005835.
      View in: PubMed
    7. Depeille P, Roose JP. Flavors of EGFR-Ras signals impacting intestinal homeostasis. Cell Cycle. 2015; 14(20):3205-6. PMID: 26292152.
      View in: PubMed
    8. Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K. PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013 Dec 03; 6(304):ra105. PMID: 24300897.
      View in: PubMed
    9. S. Barr, B. L. Falcon, P. C. Ghokale, J. Chou, J. Fogarty, P. Depeille, M. Miglarese, D. M. Epstein. Abstract B1: Dual mTORC1/mTORC2 inhibition limits tumor growth, VEGF production and vascular regrowth. Clinical Cancer Research. 2012 May 15; 18(10_Supplement):b1-b1.
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    10. Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. STIM1, PKC-d and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol. 2011 May; 12(5):425-33. PMID: 21441934.
      View in: PubMed
    11. Falcon BL, Barr S, Gokhale PC, Chou J, Fogarty J, Depeille P, Miglarese M, Epstein DM, McDonald DM. Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res. 2011 Mar 01; 71(5):1573-83. PMID: 21363918.
      View in: PubMed
    12. Ernesto Diaz-Flores, Hana Leah Goldschmidt, Philippe Depeille, Victor Ng, Jeroen Roose, Kevan Shokat, Benjamin S. Braun, Kevin Shannon. PI3 Kinase, Phospholipase C (PLC)-?, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells. Blood. 2009 Nov 20; 114(22):2512-2512.
      View in: Publisher Site
    13. Depeille P, Young JJ, Boguslawski EA, Berghuis BD, Kort EJ, Resau JH, Frankel AE, Duesbery NS. Anthrax lethal toxin inhibits growth of and vascular endothelial growth factor release from endothelial cells expressing the human herpes virus 8 viral G protein coupled receptor. Clin Cancer Res. 2007 Oct 01; 13(19):5926-34. PMID: 17908989.
      View in: PubMed
    14. Depeille PE, Ding Y, Bromberg-White JL, Duesbery NS. MKK signaling and vascularization. Oncogene. 2007 Feb 26; 26(9):1290-6. PMID: 17322914.
      View in: PubMed
    15. Passagne I, Evrard A, Depeille P, Cuq P, Cupissol D, Vian L. O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C. Toxicol Appl Pharmacol. 2006 Mar 01; 211(2):97-105. PMID: 16039682.
      View in: PubMed
    16. Depeille P, Cuq P, Mary S, Passagne I, Evrard A, Cupissol D, Vian L. Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects. Mol Pharmacol. 2004 Apr; 65(4):897-905. PMID: 15044619.
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    17. Passagne I, Evrard A, Winum JY, Depeille P, Cuq P, Montero JL, Cupissol D, Vian L. Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression. J Pharmacol Exp Ther. 2003 Nov; 307(2):816-23. PMID: 12970393.
      View in: PubMed