Piotr Hadaczek, PhD

InstitutionUniversity of California San Francisco
DepartmentNeurological Surgery
Address1855 Folsom Street
San Francisco CA 94103
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    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco, Dept. of NeurosurgeryPostdoctoral Fellow2001Gene Therapy of the CNS
    Thomas Jefferson University, Kimmel Cancer CenterPostdoctoral Fellow1996Cancer Genetics
    Pomeranian Medical University, Szczecin, Poland, Dept. of Genetics and PathologyPh.D. (cum laude)1995Cancer Genetics
    University of Szczecin, Poland, Dept. of BiologyM.Sc.1992Biology
    Collapse Awards and Honors
    Pomeranian Academy of Medicine, Szczecin, Poland1995  - 1995Scientific Award of Rector of PAM
    Pomeranian Academy of Medicine, Szczecin, Poland1996  - 1996Scientific Award of Rector of PAM
    Polish Ministry of Health and Social Care1997  - 1997Award of Ministry of Health and Social Care
    Foundation for Polish Science1998  - 1998Scholarship of Foundation for Polish Science
    Polish Ministry of Health and Social Care1999  - 1999Award of Ministry of Health and Social Care
    Polish Ministry of Health and Social Care2000  - 2000Award of Ministry of Health and Social Care

    Collapse Overview 
    Collapse Overview
    My research experience has been focused for many years on translational neuroscience. I have participated extensively in the creation of novel approaches for the delivery of therapeutic agents to specific target regions within the brain to develop effective treatments for brain diseases. In addition, I have developed release assays for clinical gene therapy products, and I am an expert on analytical method development and optimization. I have run and supervised many projects (preclinical studies) that, with the help of industry partners (Avigen, Genzyme), culminated in a clinical trial at UCSF and another at NIH. In that context, I have acquired considerable expertise in the supervision of technical staff and managing small research groups. I am very confident in my ability to direct R&D programs in the neuroscience (Parkinson’s disease) and oncology (brain tumor) fields. My main interest has been in the treatment of Parkinson’s disease via gene transfer and direct infusion of neurotrophic factors to counter neurodegeneration, and it is the area in which I have published many of my papers.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Naidoo J, Stanek LM, Ohno K, Trewman S, Samaranch L, Hadaczek P, O'Riordan C, Sullivan J, San Sebastian W, Bringas JR, Snieckus C, Mahmoodi A, Mahmoodi A, Forsayeth J, Bankiewicz KS, Shihabuddin LS. Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS. Mol Ther. 2018 Jul 12. PMID: 30057240.
      View in: PubMed
    2. Forsayeth J, Hadaczek P. Ganglioside Metabolism and Parkinson's Disease. Front Neurosci. 2018; 12:45. PMID: 29459819.
      View in: PubMed
    3. Samaranch L, Blits B, San Sebastian W, Hadaczek P, Bringas J, Sudhakar V, Macayan M, Pivirotto PJ, Petry H, Bankiewicz KS. MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain. Gene Ther. 2017 04; 24(4):253-261. PMID: 28300083.
      View in: PubMed
    4. Dreisig K, Degn M, Sund L, Hadaczek P, Samaranch L, San Sebastian W, Bankiewicz K, Rahbek Kornum B. Validation of antibodies for neuroanatomical localization of the P2Y11 receptor in macaque brain. J Chem Neuroanat. 2016 Dec; 78:25-33. PMID: 27515691.
      View in: PubMed
    5. Hadaczek P, Stanek L, Ciesielska A, Sudhakar V, Samaranch L, Pivirotto P, Bringas J, O'Riordan C, Mastis B, San Sebastian W, Forsayeth J, Cheng SH, Bankiewicz KS, Shihabuddin LS. Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease. Mol Ther Methods Clin Dev. 2016; 3:16037. PMID: 27408903; PMCID: PMC4926858.
    6. Samaranch L, Hadaczek P, Kells AP, Bringas JR, Stockinger D, San Sebastian W, Macayan M, Samineni S, Pivirotto P, Forsayeth J, Bankiewicz KS. Slow AAV2 clearance from the brain of nonhuman primates and anti-capsid immune response. Gene Ther. 2016 Apr; 23(4):393-8. PMID: 26510688.
      View in: PubMed
    7. Soroceanu L, Matlaf L, Khan S, Akhavan A, Singer E, Bezrookove V, Decker S, Ghanny S, Hadaczek P, Bengtsson H, Ohlfest J, Luciani-Torres MG, Harkins L, Perry A, Guo H, Soteropoulos P, Cobbs CS. Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma. Cancer Res. 2015 Aug 01; 75(15):3065-76. PMID: 26239477; PMCID: PMC4526117.
    8. Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol. 2015 Jan; 263:177-89. PMID: 25448159.
      View in: PubMed
    9. San Sebastian W, Kells AP, Bringas J, Samaranch L, Hadaczek P, Ciesielska A, Macayan M, Pivirotto PJ, Forsayeth J, Osborne S, Wright JF, Green F, Heller G, Bankiewicz KS. SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE. Mol Ther Methods Clin Dev. 2014 Oct 15; 3. PMID: 25541617.
      View in: PubMed
    10. Joniec-Maciejak I, Ciesielska A, Wawer A, Sznejder-Pacholek A, Schwenkgrub J, Cudna A, Hadaczek P, Bankiewicz KS, Czlonkowska A, Czlonkowski A. The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease. Pharmacol Rep. 2014 Aug; 66(4):660-9. PMID: 24948069.
      View in: PubMed
    11. Salegio EA, Streeter H, Dube N, Hadaczek P, Samaranch L, Kells AP, San Sebastian W, Zhai Y, Bringas J, Xu T, Forsayeth J, Bankiewicz KS. Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy. Front Neuroanat. 2014; 8:9. PMID: 24672434; PMCID: PMC3956368.
    12. Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW. Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors. Nanomedicine (Lond). 2014 Jul; 9(14):2099-108. PMID: 24494810.
      View in: PubMed
    13. Hadaczek P, Ozawa T, Soroceanu L, Yoshida Y, Matlaf L, Singer E, Fiallos E, James CD, Cobbs CS. Cidofovir: a novel antitumor agent for glioblastoma. Clin Cancer Res. 2013 Dec 01; 19(23):6473-83. PMID: 24170543; PMCID: PMC3919795.
    14. Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright JF, Bankiewicz KS, Forsayeth J. Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses. Mol Ther. 2013 Jan; 21(1):158-66. PMID: 22929660; PMCID: PMC3538301.
    15. Mendiburu-Eliçabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS. Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study. J Neurooncol. 2012 May; 108(1):53-8. PMID: 22350373.
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    16. Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. PLoS One. 2011; 6(11):e27728. PMID: 22132130; PMCID: PMC3221672.
    17. Ziegler RJ, Salegio EA, Dodge JC, Bringas J, Treleaven CM, Bercury SD, Tamsett TJ, Shihabuddin L, Hadaczek P, Fiandaca M, Bankiewicz K, Scheule RK. Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion. Exp Neurol. 2011 Oct; 231(2):261-71. PMID: 21777586.
      View in: PubMed
    18. Ciesielska A, Mittermeyer G, Hadaczek P, Kells AP, Forsayeth J, Bankiewicz KS. Anterograde axonal transport of AAV2-GDNF in rat basal ganglia. Mol Ther. 2011 May; 19(5):922-7. PMID: 21102559; PMCID: PMC3098627.
    19. Salegio EA, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi SP, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz KS. Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders. Hum Gene Ther. 2010 Sep; 21(9):1093-103. PMID: 20408734; PMCID: PMC2936496.
    20. Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. J Neurosci. 2010 Jul 14; 30(28):9567-77. PMID: 20631185; PMCID: PMC2914692.
    21. Su X, Kells AP, Salegio EA, Salegio EA, Richardson RM, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS. Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors. Mol Ther. 2010 Aug; 18(8):1490-5. PMID: 20551915; PMCID: PMC2927064.
    22. Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS. Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC. Mol Ther. 2010 Aug; 18(8):1458-61. PMID: 20531394; PMCID: PMC2927057.
    23. Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS. Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology. 2010 Jun; 58(7):1114-21. PMID: 20153340; PMCID: PMC2849906.
    24. Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, Forsayeth J, Bankiewicz KS. Image-guided convection-enhanced delivery of GDNF protein into monkey putamen. Neuroimage. 2011 Jan; 54 Suppl 1:S189-95. PMID: 20080195.
      View in: PubMed
    25. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Hum Gene Ther. 2009 Dec; 20(12):1627-40. PMID: 19671001; PMCID: PMC2861959.
    26. Grahn AY, Bankiewicz KS, Dugich-Djordjevic M, Bringas JR, Hadaczek P, Johnson GA, Eastman S, Luz M. Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience. J Neurooncol. 2009 Nov; 95(2):185-197. PMID: 19466380; PMCID: PMC2759007.
    27. Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):497-510. PMID: 19203243; PMCID: PMC2767387.
    28. Hadaczek P, Forsayeth J, Mirek H, Munson K, Bringas J, Pivirotto P, McBride JL, Davidson BL, Bankiewicz KS. Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response. Hum Gene Ther. 2009 Mar; 20(3):225-37. PMID: 19292604; PMCID: PMC2730589.
    29. Kells AP, Hadaczek P, Yin D, Bringas J, Varenika V, Forsayeth J, Bankiewicz KS. Efficient gene therapy-based method for the delivery of therapeutics to primate cortex. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2407-11. PMID: 19193857; PMCID: PMC2650169.
    30. Varenika V, Kells AP, Valles F, Hadaczek P, Forsayeth J, Bankiewicz KS. Controlled dissemination of AAV vectors in the primate brain. Prog Brain Res. 2009; 175:163-72. PMID: 19660655.
      View in: PubMed
    31. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35. PMID: 19095069; PMCID: PMC2730220.
    32. Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther. 2008 Aug; 16(8):1392-9. PMID: 18545225; PMCID: PMC2725180.
    33. Hadaczek P, Yamashita Y, Mirek H, Tamas L, Bohn MC, Noble C, Park JW, Bankiewicz K. The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther. 2006 Jul; 14(1):69-78. PMID: 16650807; PMCID: PMC2730223.
    34. Hadaczek P, Kohutnicka M, Krauze MT, Bringas J, Pivirotto P, Cunningham J, Bankiewicz K. Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain. Hum Gene Ther. 2006 Mar; 17(3):291-302. PMID: 16544978.
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    35. Kardas I, Mrózek K, Babinska M, Krajka K, Hadaczek P, Lubinski J, Roszkiewicz A, Kuziemska E, Limon J. Cytogenetic and molecular findings in 75 clear cell renal cell carcinomas. Oncol Rep. 2005 May; 13(5):949-56. PMID: 15809763.
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    36. Hadaczek P, Mirek H, Berger MS, Bankiewicz K. Limited efficacy of gene transfer in herpes simplex virus-thymidine kinase/ganciclovir gene therapy for brain tumors. J Neurosurg. 2005 Feb; 102(2):328-35. PMID: 15739562.
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    37. Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas JR, Drummond DC, Hong K, Kirpotin DB, McKnight T, Berger MS, Park JW, Bankiewicz KS. Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol. 2004 May; 68(1):1-9. PMID: 15174514.
      View in: PubMed
    38. Hadaczek P, Mirek H, Bringas J, Cunningham J, Bankiewicz K. Basic fibroblast growth factor enhances transduction, distribution, and axonal transport of adeno-associated virus type 2 vector in rat brain. Hum Gene Ther. 2004 May; 15(5):469-79. PMID: 15144577.
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    39. Jakubowska A, Górski B, Byrski T, Huzarski T, Gronwald J, Menkiszak J, Cybulski C, Debniak T, Hadaczek P, Scott RJ, Lubinski J. Detection of germline mutations in the BRCA1 gene by RNA-based sequencing. Hum Mutat. 2001 Aug; 18(2):149-56. PMID: 11462239.
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    40. Jakubowska A, Górski B, Kurzawski G, Debniak T, Hadaczek P, Cybulski C, Kladny J, Oszurek O, Scott RJ, Lubinski J. Optimization of experimental conditions for RNA-based sequencing of MLH1 and MSH2 genes. Hum Mutat. 2001; 17(1):52-60. PMID: 11139242.
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    41. Hadaczek P, Gronwald J, Chosia M, Huebner K, Lubinski J. Fhit protein expression in endometrial cancers: no correlation with histological grade. Pol J Pathol. 2001; 52(4):199-203. PMID: 11915181.
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    42. Hadaczek P, Debniak T, Kurzawski G, Jakubowska A, Huzarski T, Huebner K, Lubinski J. Fhit protein expression in hereditary and sporadic colorectal cancers. Pol J Pathol. 2001; 52(3):125-32. PMID: 11769399.
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    43. Hadaczek P, Kovatich A, Gronwald J, Lubinski J, Huebner K, McCue PA. Loss or reduction of Fhit expression in renal neoplasias: correlation with histogenic class. Hum Pathol. 1999 Nov; 30(11):1276-83. PMID: 10571505.
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    44. Gronwald J, Hadaczek P, Störkel S, Holtgreve-Grez H, Rabbitts P, Cremer T, Lubinski J. Molecular evidence for derivation of metastatic cells from minor subclones of primary clear renal cell carcinomas. Cancer Detect Prev. 1999; 23(6):479-84. PMID: 10571658.
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    45. Hadaczek P, Siprashvili Z, Markiewski M, Domagala W, Druck T, McCue PA, Pekarsky Y, Ohta M, Huebner K, Lubinski J. Absence or reduction of Fhit expression in most clear cell renal carcinomas. Cancer Res. 1998 Jul 15; 58(14):2946-51. PMID: 9679951.
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    46. Gronwald J, Störkel S, Holtgreve-Grez H, Hadaczek P, Brinkschmidt C, Jauch A, Lubinski J, Cremer T. Comparison of DNA gains and losses in primary renal clear cell carcinomas and metastatic sites: importance of 1q and 3p copy number changes in metastatic events. Cancer Res. 1997 Feb 01; 57(3):481-7. PMID: 9012478.
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    47. Hadaczek P, Podolski J, Toloczko A, Kurzawski G, Sikorski A, Rabbitts P, Huebner K, Lubinski J. Losses at 3p common deletion sites in subtypes of kidney tumours: histopathological correlations. Virchows Arch. 1996 Sep; 429(1):37-42. PMID: 8865851.
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    48. Druck T, Kastury K, Hadaczek P, Podolski J, Toloczko A, Sikorski A, Ohta M, LaForgia S, Lasota J, McCue P. Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas. Cancer Res. 1995 Nov 15; 55(22):5348-53. PMID: 7585599.
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    49. Podolski J, Hadaczek P, Gibas Z, Gibas L, Grossman HB, Limon J, Huebner K, Lubinski J. Non-isotopic procedure with silver staining of polyacrylamide gels in detection of genomic abnormalities in tumors using microsatellites. Folia Histochem Cytobiol. 1995; 33(2):117-23. PMID: 8617377.
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    50. Lubinski J, Podolski J, Hadaczek P, Mioduszewska O, Rylski M, Huebner K. Environmental factors may regulate BCL2 associated lymphomagenesis: a very low incidence of BCL2-MBR translocation in Poland. Pol J Pathol. 1995; 46(4):219-24. PMID: 8713288.
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    51. Lubinski J, Hadaczek P, Podolski J, Toloczko A, Sikorski A, McCue P, Druck T, Huebner K. Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas. Cancer Res. 1994 Jul 15; 54(14):3710-3. PMID: 8033088.
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    52. Rzepka-Górska I, Blogowska A, Zielinska D, Lubinski J, Podolski J, Hadaczek P, Górski B, Debniak T. [HPV virus infections and other promotion factors of the carcinogenic process in girls]. Ginekol Pol. 1993 Jul; 64(7):322-5. PMID: 8397150.
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    53. Podolski J, Hadaczek P, Cpbulski C, Rylski M, Sumera K, Sowinska E, Uznanski B, Rzepka-Górska I, Lubinski J. [Detection of tumor virus infections with HPV 16, 18, and 33 from cytologic material in the uterine neck using the PCR method]. Ginekol Pol. 1993 Jul; 64(7):326-31. PMID: 8397151.
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