Loading...

Piotr Hadaczek, PhD

Title(s)Researcher, Neurological Surgery
SchoolSchool of Medicine
Phone415-476-1125
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco, Dept. of NeurosurgeryPostdoctoral Fellow2001Gene Therapy of the CNS
    Thomas Jefferson University, Kimmel Cancer CenterPostdoctoral Fellow1996Cancer Genetics
    Pomeranian Medical University, Szczecin, Poland, Dept. of Genetics and PathologyPh.D. (cum laude)1995Cancer Genetics
    University of Szczecin, Poland, Dept. of BiologyM.Sc.1992Biology
    Collapse Awards and Honors
    Pomeranian Academy of Medicine, Szczecin, Poland1995  - 1995Scientific Award of Rector of PAM
    Pomeranian Academy of Medicine, Szczecin, Poland1996  - 1996Scientific Award of Rector of PAM
    Polish Ministry of Health and Social Care1997  - 1997Award of Ministry of Health and Social Care
    Foundation for Polish Science1998  - 1998Scholarship of Foundation for Polish Science
    Polish Ministry of Health and Social Care1999  - 1999Award of Ministry of Health and Social Care
    Polish Ministry of Health and Social Care2000  - 2000Award of Ministry of Health and Social Care

    Collapse Overview 
    Collapse Overview
    My research experience has been focused for many years on translational neuroscience. I have participated extensively in the creation of novel approaches for the delivery of therapeutic agents to specific target regions within the brain to develop effective treatments for brain diseases. In addition, I have developed release assays for clinical gene therapy products, and I am an expert on analytical method development and optimization. I have run and supervised many projects (preclinical studies) that, with the help of industry partners (Avigen, Genzyme), culminated in a clinical trial at UCSF and another at NIH. In that context, I have acquired considerable expertise in the supervision of technical staff and managing small research groups. I am very confident in my ability to direct R&D programs in the neuroscience (Parkinson’s disease) and oncology (brain tumor) fields. My main interest has been in the treatment of Parkinson’s disease via gene transfer and direct infusion of neurotrophic factors to counter neurodegeneration, and it is the area in which I have published many of my papers.

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Ohno K, Samaranch L, Hadaczek P, Bringas JR, Allen PC, Sudhakar V, Stockinger DE, Snieckus C, Campagna MV, San Sebastian W, Naidoo J, Chen H, Forsayeth J, Salegio EA, Hwa GGC, Bankiewicz KS. Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates. Mol Ther Methods Clin Dev. 2019 Jun 14; 13:47-54. PMID: 30666308.
      View in: PubMed
    2. Naidoo J, Stanek LM, Ohno K, Trewman S, Samaranch L, Hadaczek P, O'Riordan C, Sullivan J, San Sebastian W, Bringas JR, Snieckus C, Mahmoodi A, Mahmoodi A, Forsayeth J, Bankiewicz KS, Shihabuddin LS. Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS. Mol Ther. 2018 Oct 03; 26(10):2418-2430. PMID: 30057240.
      View in: PubMed
    3. Forsayeth J, Hadaczek P. Ganglioside Metabolism and Parkinson's Disease. Front Neurosci. 2018; 12:45. PMID: 29459819.
      View in: PubMed
    4. Dreisig K, Degn M, Sund L, Hadaczek P, Samaranch L, San Sebastian W, Bankiewicz K, Rahbek Kornum B. Validation of antibodies for neuroanatomical localization of the P2Y11 receptor in macaque brain. J Chem Neuroanat. 2016 12; 78:25-33. PMID: 27515691.
      View in: PubMed
    5. Hadaczek P, Stanek L, Ciesielska A, Sudhakar V, Samaranch L, Pivirotto P, Bringas J, O'Riordan C, Mastis B, San Sebastian W, Forsayeth J, Cheng SH, Bankiewicz KS, Shihabuddin LS. Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease. Mol Ther Methods Clin Dev. 2016; 3:16037. PMID: 27408903; PMCID: PMC4926858.
    6. Soroceanu L, Matlaf L, Khan S, Akhavan A, Singer E, Bezrookove V, Decker S, Ghanny S, Hadaczek P, Bengtsson H, Ohlfest J, Luciani-Torres MG, Harkins L, Perry A, Guo H, Soteropoulos P, Cobbs CS. Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma. Cancer Res. 2015 Aug 01; 75(15):3065-76. PMID: 26239477; PMCID: PMC4526117.
    7. Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol. 2015 Jan; 263:177-89. PMID: 25448159.
      View in: PubMed
    8. San Sebastian W, Kells AP, Bringas J, Samaranch L, Hadaczek P, Ciesielska A, Macayan M, Pivirotto PJ, Forsayeth J, Osborne S, Wright JF, Green F, Heller G, Bankiewicz KS. SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE. Mol Ther Methods Clin Dev. 2014 Oct 15; 3. PMID: 25541617.
      View in: PubMed
    9. Joniec-Maciejak I, Ciesielska A, Wawer A, Sznejder-Pacholek A, Schwenkgrub J, Cudna A, Hadaczek P, Bankiewicz KS, Czlonkowska A, Czlonkowski A. The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease. Pharmacol Rep. 2014 Aug; 66(4):660-9. PMID: 24948069.
      View in: PubMed
    10. Salegio EA, Streeter H, Dube N, Hadaczek P, Samaranch L, Kells AP, San Sebastian W, Zhai Y, Bringas J, Xu T, Forsayeth J, Bankiewicz KS. Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy. Front Neuroanat. 2014; 8:9. PMID: 24672434; PMCID: PMC3956368.
    11. Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW. Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors. Nanomedicine (Lond). 2014 Jul; 9(14):2099-108. PMID: 24494810.
      View in: PubMed
    12. Hadaczek P, Ozawa T, Soroceanu L, Yoshida Y, Matlaf L, Singer E, Fiallos E, James CD, Cobbs CS. Cidofovir: a novel antitumor agent for glioblastoma. Clin Cancer Res. 2013 Dec 01; 19(23):6473-83. PMID: 24170543; PMCID: PMC3919795.
    13. Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright JF, Bankiewicz KS, Forsayeth J. Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses. Mol Ther. 2013 Jan; 21(1):158-66. PMID: 22929660; PMCID: PMC3538301.
    14. Mendiburu-Eliçabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS. Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study. J Neurooncol. 2012 May; 108(1):53-8. PMID: 22350373.
      View in: PubMed
    15. Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. PLoS One. 2011; 6(11):e27728. PMID: 22132130; PMCID: PMC3221672.
    16. Ziegler RJ, Salegio EA, Dodge JC, Bringas J, Treleaven CM, Bercury SD, Tamsett TJ, Shihabuddin L, Hadaczek P, Fiandaca M, Bankiewicz K, Scheule RK. Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion. Exp Neurol. 2011 Oct; 231(2):261-71. PMID: 21777586.
      View in: PubMed
    17. Ciesielska A, Mittermeyer G, Hadaczek P, Kells AP, Forsayeth J, Bankiewicz KS. Anterograde axonal transport of AAV2-GDNF in rat basal ganglia. Mol Ther. 2011 May; 19(5):922-7. PMID: 21102559; PMCID: PMC3098627.
    18. Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. J Neurosci. 2010 Jul 14; 30(28):9567-77. PMID: 20631185; PMCID: PMC2914692.
    19. Su X, Kells AP, Salegio EA, Salegio EA, Richardson RM, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS. Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors. Mol Ther. 2010 Aug; 18(8):1490-5. PMID: 20551915; PMCID: PMC2927064.
    20. Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS. Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC. Mol Ther. 2010 Aug; 18(8):1458-61. PMID: 20531394; PMCID: PMC2927057.
    21. Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS. Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology. 2010 Jun; 58(7):1114-21. PMID: 20153340; PMCID: PMC2849906.
    22. Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, Forsayeth J, Bankiewicz KS. Image-guided convection-enhanced delivery of GDNF protein into monkey putamen. Neuroimage. 2011 Jan; 54 Suppl 1:S189-95. PMID: 20080195.
      View in: PubMed
    23. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Hum Gene Ther. 2009 Dec; 20(12):1627-40. PMID: 19671001; PMCID: PMC2861959.
    24. Grahn AY, Bankiewicz KS, Dugich-Djordjevic M, Bringas JR, Hadaczek P, Johnson GA, Eastman S, Luz M. Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience. J Neurooncol. 2009 Nov; 95(2):185-197. PMID: 19466380; PMCID: PMC2759007.
    25. Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):497-510. PMID: 19203243; PMCID: PMC2767387.
    26. Hadaczek P, Forsayeth J, Mirek H, Munson K, Bringas J, Pivirotto P, McBride JL, Davidson BL, Bankiewicz KS. Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response. Hum Gene Ther. 2009 Mar; 20(3):225-37. PMID: 19292604; PMCID: PMC2730589.
    27. Kells AP, Hadaczek P, Yin D, Bringas J, Varenika V, Forsayeth J, Bankiewicz KS. Efficient gene therapy-based method for the delivery of therapeutics to primate cortex. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2407-11. PMID: 19193857; PMCID: PMC2650169.
    28. Varenika V, Kells AP, Valles F, Hadaczek P, Forsayeth J, Bankiewicz KS. Controlled dissemination of AAV vectors in the primate brain. Prog Brain Res. 2009; 175:163-72. PMID: 19660655.
      View in: PubMed
    29. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35. PMID: 19095069; PMCID: PMC2730220.
    30. Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther. 2008 Aug; 16(8):1392-9. PMID: 18545225; PMCID: PMC2725180.
    31. Hadaczek P, Yamashita Y, Mirek H, Tamas L, Bohn MC, Noble C, Park JW, Bankiewicz K. The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther. 2006 Jul; 14(1):69-78. PMID: 16650807; PMCID: PMC2730223.
    32. Hadaczek P, Kohutnicka M, Krauze MT, Bringas J, Pivirotto P, Cunningham J, Bankiewicz K. Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain. Hum Gene Ther. 2006 Mar; 17(3):291-302. PMID: 16544978.
      View in: PubMed
    33. Kardas I, Mrózek K, Babinska M, Krajka K, Hadaczek P, Lubinski J, Roszkiewicz A, Kuziemska E, Limon J. Cytogenetic and molecular findings in 75 clear cell renal cell carcinomas. Oncol Rep. 2005 May; 13(5):949-56. PMID: 15809763.
      View in: PubMed
    34. Hadaczek P, Mirek H, Berger MS, Bankiewicz K. Limited efficacy of gene transfer in herpes simplex virus-thymidine kinase/ganciclovir gene therapy for brain tumors. J Neurosurg. 2005 Feb; 102(2):328-35. PMID: 15739562.
      View in: PubMed
    35. Hadaczek P, Mirek H, Bringas J, Cunningham J, Bankiewicz K. Basic fibroblast growth factor enhances transduction, distribution, and axonal transport of adeno-associated virus type 2 vector in rat brain. Hum Gene Ther. 2004 May; 15(5):469-79. PMID: 15144577.
      View in: PubMed
    36. Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas JR, Drummond DC, Hong K, Kirpotin DB, McKnight T, Berger MS, Park JW, Bankiewicz KS. Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol. 2004 May; 68(1):1-9. PMID: 15174514.
      View in: PubMed