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Rahul Deo, MD, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Phone415-514-0992
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    Collapse Biography 
    Collapse Education and Training
    Weill Cornell Medical UniversityM.D.2003School of Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Rahul Deo was born and raised in Canada and earned his medical degree from Cornell University Medical College and PhD in Molecular Biophysics from the Rockefeller University as part of the Tri-Institutional MD-PhD Program. He completed his internship and residency in Internal Medicine at Brigham and Women’s Hospital and Cardiology Fellowship at the Massachusetts General Hospital. He then conducted postdoctoral research in human genetics and computational biology at Harvard Medical School. Dr. Deo’s clinical and research interests involve bringing large-scale genetic and genomic data and emerging computational approaches towards the goal of personalized diagnosis and therapy in cardiovascular medicine. He focuses on patients with inherited cardiovascular disease, particularly cardiomyopathies.

    Medical School: Weill Medical College of Cornell University
    Graduate School: The Rockefeller University
    Residency: Brigham and Women’s Hospital
    Fellowship: Massachusetts General Hospital

    Certifications:
    - Internal Medicine 2006
    - Cardiology 2010

    Collapse Research 
    Collapse Research Activities and Funding
    Machine learning for the automated identification and tracking of rare myocardial diseases
    NIH/NHLBI R01HL140731Jul 5, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Resolving Incomplete Penetrance in the Cardiomyopathies and Channelopathies
    NIH/NHLBI DP2HL123228Sep 30, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Integrating lipid genotyes and phenotypes in iPS derived hepatocytes/adipocytes
    NIH/NHLBI U01HL107440Jul 5, 2011 - Jun 30, 2016
    Role: Co-Principal Investigator
    Bioinformatic Approaches to Small Molecule Profiling of Cardiometabolic Disease
    NIH/NHLBI K08HL098361Jul 15, 2010 - Feb 28, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bajaj NS, Singh A, Zhou W, Gupta A, Fujikura K, Byrne C, Harms HJ, Osborne MT, Bravo P, Andrikopoulou E, Divakaran S, Bibbo CF, Hainer J, Skali H, Taqueti V, Steigner M, Dorbala S, Charytan DM, Prabhu SD, Blankstein R, Deo RC, Solomon SD, Di Carli MF. Coronary Microvascular Dysfunction, Left Ventricular Remodeling and Clinical Outcomes in Patients with Chronic Kidney Impairment. Circulation. 2019 11 29. PMID: 31779467.
      View in: PubMed
    2. Tison GH, Zhang J, Delling FN, Deo RC. Automated and Interpretable Patient ECG Profiles for Disease Detection, Tracking, and Discovery. Circ Cardiovasc Qual Outcomes. 2019 Sep; 12(9):e005289. PMID: 31525078.
      View in: PubMed
    3. Ahsan Huda, Sanjiv J. Shah, Adam Castano, Anindita Niyogi, Jennifer Schumacher, Michelle Stewart, Rahul Deo. A Machine Learning Model for the Systematic Identification of Wild-Type Transthyretin Cardiomyopathy. Journal of Cardiac Failure. 2019 Aug 1; 25(8):s53-s54.
      View in: Publisher Site
    4. Erron W. Titus, Frederick H. Deiter, Chenxu Shi, Julianne Wojciak, Melvin Scheinman, Natalia Jura, Rahul C. Deo. The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia. bioRxiv. 2019 Jun 15; 672303.
      View in: Publisher Site
    5. Zhang J, Deo RC. Response by Zhang and Deo to Letter Regarding Article, "Fully Automated Echocardiogram Interpretation in Clinical Practice: Feasibility and Diagnostic Accuracy". Circulation. 2019 03 26; 139(13):1648-1649. PMID: 30908098.
      View in: PubMed
    6. Divanji P, Deo R, Harris I. Coronary Arteries and the Cell Count. Circulation. 2019 02 26; 139(9):1228-1233. PMID: 30857407.
      View in: PubMed
    7. Zhang J, Gajjala S, Agrawal P, Tison GH, Hallock LA, Beussink-Nelson L, Lassen MH, Fan E, Aras MA, Jordan C, Fleischmann KE, Melisko M, Qasim A, Shah SJ, Bajcsy R, Deo RC. Fully Automated Echocardiogram Interpretation in Clinical Practice. Circulation. 2018 10 16; 138(16):1623-1635. PMID: 30354459.
      View in: PubMed
    8. Golbus JR, Nallamothu BK, Deo RC. MAGUS: A Shared Tool for the Genetic Community. Circ Cardiovasc Qual Outcomes. 2018 10; 11(10):e005006. PMID: 30354584.
      View in: PubMed
    9. Wu RS, Lam II, Clay H, Duong DN, Deo RC, Coughlin SR. A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish. Dev Cell. 2018 07 02; 46(1):112-125.e4. PMID: 29974860.
      View in: PubMed
    10. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2017 12 14; 171(7):1707. PMID: 29245014.
      View in: PubMed
    11. Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes. 2018 02; 67(2):208-221. PMID: 29203511.
      View in: PubMed
    12. Friesen M, Camahort R, Lee YK, Xia F, Gerszten RE, Rhee EP, Deo RC, Cowan CA. Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease. Stem Cell Reports. 2017 05 09; 8(5):1164-1173. PMID: 28416283.
      View in: PubMed
    13. Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MHC, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017 04 06; 20(4):547-557.e7. PMID: 28388431.
      View in: PubMed
    14. Katz DH, Deo RC, Aguilar FG, Selvaraj S, Martinez EE, Beussink-Nelson L, Kim KA, Peng J, Irvin MR, Tiwari H, Rao DC, Arnett DK, Shah SJ. Phenomapping for the Identification of Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection Fraction. J Cardiovasc Transl Res. 2017 Jun; 10(3):275-284. PMID: 28258421.
      View in: PubMed
    15. Roberts JD, Gollob MH, Young C, Connors SP, Gray C, Wilton SB, Green MS, Zhu DW, Hodgkinson KA, Poon A, Li Q, Orr N, Tang AS, Klein GJ, Wojciak J, Campagna J, Olgin JE, Badhwar N, Vedantham V, Marcus GM, Kwok PY, Deo RC, Scheinman MM. Bundle Branch Re-Entrant Ventricular Tachycardia: Novel Genetic Mechanisms in a Life-Threatening Arrhythmia. JACC Clin Electrophysiol. 2017 03; 3(3):276-288. PMID: 29759522.
      View in: PubMed
    16. Deo RC, Nallamothu BK. Learning About Machine Learning: The Promise and Pitfalls of Big Data and the Electronic Health Record. Circ Cardiovasc Qual Outcomes. 2016 11; 9(6):618-620. PMID: 28263936.
      View in: PubMed
    17. Deo RC. Alternative Splicing, Internal Promoter, Nonsense-Mediated Decay, or All Three: Explaining the Distribution of Truncation Variants in Titin. Circ Cardiovasc Genet. 2016 Oct; 9(5):419-425. PMID: 27625338.
      View in: PubMed
    18. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11; 166(4):841-854. PMID: 27453471.
      View in: PubMed
    19. Deo RC. Editorial commentary: Induced pluripotent stem cell (IPSC) cardiomyocytes: My kingdom for a useful disease model! Trends Cardiovasc Med. 2016 11; 26(8):673-674. PMID: 27349929.
      View in: PubMed
    20. Deo RC. Machine Learning in Medicine. Circulation. 2015 Nov 17; 132(20):1920-30. PMID: 26572668.
      View in: PubMed
    21. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406. PMID: 26473617.
      View in: PubMed
    22. Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet. 2015 Apr; 8(2):343-50. PMID: 25632026.
      View in: PubMed
    23. Vedantham V, Galang G, Evangelista M, Deo RC, Srivastava D. RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells. Circ Res. 2015 Feb 27; 116(5):797-803. PMID: 25623957.
      View in: PubMed
    24. Deo RC, Musso G, Tasan M, Tang P, Poon A, Yuan C, Felix JF, Vasan RS, Beroukhim R, De Marco T, Kwok PY, MacRae CA, Roth FP. Prioritizing causal disease genes using unbiased genomic features. Genome Biol. 2014 Dec 03; 15(12):534. PMID: 25633252.
      View in: PubMed
    25. Roberts JD, Longoria J, Poon A, Gollob MH, Dewland TA, Kwok PY, Olgin JE, Deo RC, Marcus GM. Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation. Circ Cardiovasc Genet. 2015 Feb; 8(1):50-7. PMID: 25406240.
      View in: PubMed
    26. Shah SJ, Katz DH, Selvaraj S, Burke MA, Yancy CW, Gheorghiade M, Bonow RO, Huang CC, Deo RC. Phenomapping for novel classification of heart failure with preserved ejection fraction. Circulation. 2015 Jan 20; 131(3):269-79. PMID: 25398313.
      View in: PubMed
    27. Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol. 2014 Oct; 71(10):1228-36. PMID: 25111166.
      View in: PubMed
    28. Shah SJ, Katz DH, Deo RC. Phenotypic spectrum of heart failure with preserved ejection fraction. Heart Fail Clin. 2014 Jul; 10(3):407-18. PMID: 24975905.
      View in: PubMed
    29. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013 Apr 11; 153(2):376-88. PMID: 23582327.
      View in: PubMed
    30. Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012 Jul 26; 487(7408):491-5. PMID: 22810586.
      View in: PubMed
    31. Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA. Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol. 2012 Jan 15; 14(2):209-19. PMID: 22246346.
      View in: PubMed
    32. Lau FH, Deo RC, Mowrer G, Caplin J, Ahfeldt T, Kaplan A, Ptaszek L, Walker JD, Rosengard BR, Cowan CA. Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue. PLoS One. 2011; 6(10):e26092. PMID: 22022522.
      View in: PubMed
    33. Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 2011 Feb 03; 470(7332):95-100. PMID: 21270795.
      View in: PubMed
    34. Deo RC, Wilson JG, Xing C, Lawson K, Kao WH, Reich D, Tandon A, Akylbekova E, Patterson N, Mosley TH, Boerwinkle E, Taylor HA. Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans. PLoS One. 2011 Jan 24; 6(1):e14581. PMID: 21283670.
      View in: PubMed
    35. Becker JR, Deo RC, Werdich AA, Panàkovà D, Coy S, MacRae CA. Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish. Dis Model Mech. 2011 May; 4(3):400-10. PMID: 21245263.
      View in: PubMed
    36. Deo RC, MacRae CA. Clinical screening and genetic testing. Clin Lab Med. 2010 Dec; 30(4):775-84. PMID: 20832651.
      View in: PubMed
    37. Deo RC, MacRae CA. The zebrafish: scalable in vivo modeling for systems biology. Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun; 3(3):335-46. PMID: 20882534.
      View in: PubMed
    38. Keebler ME, Deo RC, Surti A, Konieczkowski D, Guiducci C, Burtt N, Buxbaum SG, Sarpong DF, Steffes MW, Wilson JG, Taylor HA, Kathiresan S. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. Circ Cardiovasc Genet. 2010 Aug; 3(4):358-64. PMID: 20570916.
      View in: PubMed
    39. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010 May 26; 2(33):33ra37. PMID: 20505214.
      View in: PubMed
    40. Deo RC, MacRae CA. Clinical screening and genetic testing. Heart Fail Clin. 2010 Apr; 6(2):231-8. PMID: 20347791.
      View in: PubMed
    41. Deo RC, Hunter L, Lewis GD, Pare G, Vasan RS, Chasman D, Wang TJ, Gerszten RE, Roth FP. Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26; 6(2):e1000692. PMID: 20195502.
      View in: PubMed
    42. Fejerman L, Haiman CA, Reich D, Tandon A, Deo RC, John EM, Ingles SA, Ambrosone CB, Bovbjerg DH, Jandorf LH, Davis W, Ciupak G, Whittemore AS, Press MF, Ursin G, Bernstein L, Huntsman S, Henderson BE, Ziv E, Freedman ML. An admixture scan in 1,484 African American women with breast cancer. Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):3110-7. PMID: 19843668.
      View in: PubMed
    43. Deo RC, Roth FP. Pathways of the heart. Circ Cardiovasc Genet. 2009 Aug; 2(4):303-5. PMID: 20031600.
      View in: PubMed
    44. Deo RC, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, Kathiresan S, Sarpong D, Taylor HA, Wilson JG. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet. 2009 Jan; 5(1):e1000342. PMID: 19148283.
      View in: PubMed
    45. Deo R, MacRae CA. The genetics of cardiomyopathies: what clinicians should know. Curr Heart Fail Rep. 2007 Dec; 4(4):229-35. PMID: 18221620.
      View in: PubMed
    46. Deo RC, Patterson N, Tandon A, McDonald GJ, Haiman CA, Ardlie K, Henderson BE, Henderson SO, Reich D. A high-density admixture scan in 1,670 African Americans with hypertension. PLoS Genet. 2007 Nov; 3(11):e196. PMID: 18020707.
      View in: PubMed
    47. Rahul Deo, Nick Patterson, Arti Tandon, Gavin McDonald, Christopher A. Haiman, Kristin Ardlie, Brian E. Henderson, Sean O Henderson, David Reich. A High-Density Admixture Scan in 1,670 African Americans with Hypertension. PLoS Genetics. 2005 Jan 1; preprint(2007):e196.
      View in: Publisher Site
    48. Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J. 2004 Jan 14; 23(1):9-22. PMID: 14685275.
      View in: PubMed
    49. Collavoli A, Hatcher CJ, He J, Okin D, Deo R, Basson CT. TBX5 nuclear localization is mediated by dual cooperative intramolecular signals. J Mol Cell Cardiol. 2003 Oct; 35(10):1191-5. PMID: 14519429.
      View in: PubMed
    50. Deo RC, Groft CM, Rajashankar KR, Burley SK. Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer. Cell. 2002 Jan 11; 108(1):71-81. PMID: 11792322.
      View in: PubMed
    51. Deo RC, Sonenberg N, Burley SK. X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4414-9. PMID: 11287654.
      View in: PubMed
    52. Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N. Translational repression by a novel partner of human poly(A) binding protein, Paip2. Mol Cell. 2001 Jan; 7(1):205-16. PMID: 11172725.
      View in: PubMed
    53. Deo RC, Bonanno JB, Sonenberg N, Burley SK. Recognition of polyadenylate RNA by the poly(A)-binding protein. Cell. 1999 Sep 17; 98(6):835-45. PMID: 10499800.
      View in: PubMed
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