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Rahul Deo, MD, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-514-0992
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    Collapse Biography 
    Collapse Education and Training
    Weill Cornell Medical UniversityM.D.2003School of Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Rahul Deo was born and raised in Canada and earned his medical degree from Cornell University Medical College and PhD in Molecular Biophysics from the Rockefeller University as part of the Tri-Institutional MD-PhD Program. He completed his internship and residency in Internal Medicine at Brigham and Women’s Hospital and Cardiology Fellowship at the Massachusetts General Hospital. He then conducted postdoctoral research in human genetics and computational biology at Harvard Medical School. Dr. Deo’s clinical and research interests involve bringing large-scale genetic and genomic data and emerging computational approaches towards the goal of personalized diagnosis and therapy in cardiovascular medicine. He focuses on patients with inherited cardiovascular disease, particularly cardiomyopathies.

    Medical School: Weill Medical College of Cornell University
    Graduate School: The Rockefeller University
    Residency: Brigham and Women’s Hospital
    Fellowship: Massachusetts General Hospital

    Certifications:
    - Internal Medicine 2006
    - Cardiology 2010


    Collapse Research 
    Collapse Research Activities and Funding
    Resolving Incomplete Penetrance in the Cardiomyopathies and Channelopathies
    NIH/NHLBI DP2HL123228Sep 30, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Integrating lipid genotyes and phenotypes in iPS derived hepatocytes/adipocytes
    NIH/NHLBI U01HL107440Jul 5, 2011 - Jun 30, 2016
    Role: Co-Principal Investigator
    Bioinformatic Approaches to Small Molecule Profiling of Cardiometabolic Disease
    NIH/NHLBI K08HL098361Jul 15, 2010 - Feb 28, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Deo R. Alternative Splicing, Internal Promoter, Nonsense-Mediated Decay, or All Three: Explaining the Distribution of Truncation Variants in Titin. Circ Cardiovasc Genet. 2016 Oct; 9(5):419-425. PMID: 27625338.
      View in: PubMed
    2. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo R, Chawla A, et al. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Jul 20. PMID: 27453471.
      View in: PubMed
    3. Deo R. Editorial commentary: Induced pluripotent stem cell (IPSC) cardiomyocytes: My kingdom for a useful disease model! Trends Cardiovasc Med. 2016 Nov; 26(8):673-674. PMID: 27349929.
      View in: PubMed
    4. Deo R. Machine Learning in Medicine. Circulation. 2015 Nov 17; 132(20):1920-30. PMID: 26572668.
      View in: PubMed
    5. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo R. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015; 4. PMID: 26473617.
      View in: PubMed
    6. Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet. 2015 Apr; 8(2):343-50. PMID: 25632026; PMCID: PMC4406825.
      View in: PubMed, PubMed Central
    7. Vedantham V, Galang G, Evangelista M, Deo R, Srivastava D. RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells. Circ Res. 2015 Feb 27; 116(5):797-803. PMID: 25623957; PMCID: PMC4344860 [Available on 02/27/16].
      View in: PubMed, PubMed Central
    8. Deo R, Musso G, Tasan M, Tang P, Poon A, Yuan C, Felix JF, Vasan RS, Beroukhim R, De Marco T, Kwok PY, MacRae CA, Roth FP. Prioritizing causal disease genes using unbiased genomic features. Genome Biol. 2014; 15(12):534. PMID: 25633252; PMCID: PMC4279789.
      View in: PubMed, PubMed Central
    9. Roberts JD, Longoria J, Poon A, Gollob MH, Dewland TA, Kwok PY, Olgin JE, Deo R, Marcus GM. Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation. Circ Cardiovasc Genet. 2015 Feb; 8(1):50-7. PMID: 25406240; PMCID: PMC4334693 [Available on 02/01/16].
      View in: PubMed, PubMed Central
    10. Shah SJ, Katz DH, Selvaraj S, Burke MA, Yancy CW, Gheorghiade M, Bonow RO, Huang CC, Deo R. Phenomapping for novel classification of heart failure with preserved ejection fraction. Circulation. 2015 Jan 20; 131(3):269-79. PMID: 25398313; PMCID: PMC4302027 [Available on 01/20/16].
      View in: PubMed, PubMed Central
    11. Mak AC, Pullinger CR, Tang LF, Wong JS, Deo R, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol. 2014 Oct; 71(10):1228-36. PMID: 25111166.
      View in: PubMed
    12. Shah SJ, Katz DH, Deo R. Phenotypic spectrum of heart failure with preserved ejection fraction. Heart Fail Clin. 2014 Jul; 10(3):407-18. PMID: 24975905; PMCID: PMC4076705.
      View in: PubMed, PubMed Central
    13. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo R, Locksley RM, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013 Apr 11; 153(2):376-88. PMID: 23582327; PMCID: PMC3663598.
      View in: PubMed, PubMed Central
    14. Rozenblatt-Rosen O, Deo R, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012 Jul 26; 487(7408):491-5. PMID: 22810586; PMCID: PMC3408847.
      View in: PubMed, PubMed Central
    15. Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo R, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA. Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol. 2012 Feb; 14(2):209-19. PMID: 22246346; PMCID: PMC3385947.
      View in: PubMed, PubMed Central
    16. Lau FH, Deo R, Mowrer G, Caplin J, Ahfeldt T, Kaplan A, Ptaszek L, Walker JD, Rosengard BR, Cowan CA. Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue. PLoS One. 2011; 6(10):e26092. PMID: 22022522; PMCID: PMC3191160.
      View in: PubMed, PubMed Central
    17. Diep CQ, Ma D, Deo R, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 2011 Feb 3; 470(7332):95-100. PMID: 21270795; PMCID: PMC3170921.
      View in: PubMed, PubMed Central
    18. Deo R, Wilson JG, Xing C, Lawson K, Kao WH, Reich D, Tandon A, Akylbekova E, Patterson N, Mosley TH, Boerwinkle E, Taylor HA. Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans. PLoS One. 2011; 6(1):e14581. PMID: 21283670; PMCID: PMC3025914.
      View in: PubMed, PubMed Central
    19. Becker JR, Deo R, Werdich AA, Panàkovà D, Coy S, MacRae CA. Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish. Dis Model Mech. 2011 May; 4(3):400-10. PMID: 21245263; PMCID: PMC3097461.
      View in: PubMed, PubMed Central
    20. Deo R, MacRae CA. Clinical screening and genetic testing. Clin Lab Med. 2010 Dec; 30(4):775-84. PMID: 20832651; PMCID: PMC4308415.
      View in: PubMed, PubMed Central
    21. Deo R, MacRae CA. The zebrafish: scalable in vivo modeling for systems biology. Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun; 3(3):335-46. PMID: 20882534; PMCID: PMC3251331.
      View in: PubMed, PubMed Central
    22. Keebler ME, Deo R, Surti A, Konieczkowski D, Guiducci C, Burtt N, Buxbaum SG, Sarpong DF, Steffes MW, Wilson JG, Taylor HA, Kathiresan S. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. Circ Cardiovasc Genet. 2010 Aug; 3(4):358-64. PMID: 20570916; PMCID: PMC3074173.
      View in: PubMed, PubMed Central
    23. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010 May 26; 2(33):33ra37. PMID: 20505214; PMCID: PMC3010398.
      View in: PubMed, PubMed Central
    24. Deo R, MacRae CA. Clinical screening and genetic testing. Heart Fail Clin. 2010 Apr; 6(2):231-8. PMID: 20347791; PMCID: PMC2874821.
      View in: PubMed, PubMed Central
    25. Deo R, Hunter L, Lewis GD, Pare G, Vasan RS, Chasman D, Wang TJ, Gerszten RE, Roth FP. Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb; 6(2):e1000692. PMID: 20195502; PMCID: PMC2829050.
      View in: PubMed, PubMed Central
    26. Fejerman L, Haiman CA, Reich D, Tandon A, Deo R, John EM, Ingles SA, Ambrosone CB, Bovbjerg DH, Jandorf LH, Davis W, Ciupak G, Whittemore AS, Press MF, Ursin G, Bernstein L, Huntsman S, Henderson BE, Ziv E, Freedman ML. An admixture scan in 1,484 African American women with breast cancer. Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):3110-7. PMID: 19843668; PMCID: PMC2783219.
      View in: PubMed, PubMed Central
    27. Deo R, Roth FP. Pathways of the heart. Circ Cardiovasc Genet. 2009 Aug; 2(4):303-5. PMID: 20031600; PMCID: PMC2823807.
      View in: PubMed, PubMed Central
    28. Deo R, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, Kathiresan S, Sarpong D, Taylor HA, Wilson JG. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet. 2009 Jan; 5(1):e1000342. PMID: 19148283; PMCID: PMC2613537.
      View in: PubMed, PubMed Central
    29. Deo R, MacRae CA. The genetics of cardiomyopathies: what clinicians should know. Curr Heart Fail Rep. 2007 Dec; 4(4):229-35. PMID: 18221620.
      View in: PubMed
    30. Deo R, Patterson N, Tandon A, McDonald GJ, Haiman CA, Ardlie K, Henderson BE, Henderson SO, Reich D. A high-density admixture scan in 1,670 African Americans with hypertension. PLoS Genet. 2007 Nov; 3(11):e196. PMID: 18020707; PMCID: PMC2077893.
      View in: PubMed, PubMed Central
    31. Deo R, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J. 2004 Jan 14; 23(1):9-22. PMID: 14685275; PMCID: PMC1271659.
      View in: PubMed, PubMed Central
    32. Collavoli A, Hatcher CJ, He J, Okin D, Deo R, Basson CT. TBX5 nuclear localization is mediated by dual cooperative intramolecular signals. J Mol Cell Cardiol. 2003 Oct; 35(10):1191-5. PMID: 14519429.
      View in: PubMed
    33. Deo R, Groft CM, Rajashankar KR, Burley SK. Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer. Cell. 2002 Jan 11; 108(1):71-81. PMID: 11792322.
      View in: PubMed
    34. Deo R, Sonenberg N, Burley SK. X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4414-9. PMID: 11287654; PMCID: PMC31849.
      View in: PubMed, PubMed Central
    35. Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo R, Burley SK, Sonenberg N. Translational repression by a novel partner of human poly(A) binding protein, Paip2. Mol Cell. 2001 Jan; 7(1):205-16. PMID: 11172725.
      View in: PubMed
    36. Deo R, Bonanno JB, Sonenberg N, Burley SK. Recognition of polyadenylate RNA by the poly(A)-binding protein. Cell. 1999 Sep 17; 98(6):835-45. PMID: 10499800.
      View in: PubMed
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