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Rahul Deo, MD, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-514-0992
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    Collapse Biography 
    Collapse Education and Training
    Weill Cornell Medical UniversityM.D.2003School of Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Rahul Deo was born and raised in Canada and earned his medical degree from Cornell University Medical College and PhD in Molecular Biophysics from the Rockefeller University as part of the Tri-Institutional MD-PhD Program. He completed his internship and residency in Internal Medicine at Brigham and Women’s Hospital and Cardiology Fellowship at the Massachusetts General Hospital. He then conducted postdoctoral research in human genetics and computational biology at Harvard Medical School. Dr. Deo’s clinical and research interests involve bringing large-scale genetic and genomic data and emerging computational approaches towards the goal of personalized diagnosis and therapy in cardiovascular medicine. He focuses on patients with inherited cardiovascular disease, particularly cardiomyopathies.

    Medical School: Weill Medical College of Cornell University
    Graduate School: The Rockefeller University
    Residency: Brigham and Women’s Hospital
    Fellowship: Massachusetts General Hospital

    Certifications:
    - Internal Medicine 2006
    - Cardiology 2010


    Collapse Research 
    Collapse Research Activities and Funding
    Resolving Incomplete Penetrance in the Cardiomyopathies and Channelopathies
    NIH/NHLBI DP2HL123228Sep 30, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Integrating lipid genotyes and phenotypes in iPS derived hepatocytes/adipocytes
    NIH/NHLBI U01HL107440Jul 5, 2011 - Jun 30, 2016
    Role: Co-Principal Investigator
    Bioinformatic Approaches to Small Molecule Profiling of Cardiometabolic Disease
    NIH/NHLBI K08HL098361Jul 15, 2010 - Feb 28, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo R, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2017 Dec 14; 171(7):1707. PMID: 29245014.
      View in: PubMed
    2. Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo R, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes. 2018 Feb; 67(2):208-221. PMID: 29203511.
      View in: PubMed
    3. Friesen M, Camahort R, Lee YK, Xia F, Gerszten RE, Rhee EP, Deo R, Cowan CA. Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease. Stem Cell Reports. 2017 05 09; 8(5):1164-1173. PMID: 28416283.
      View in: PubMed
    4. Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MH, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo R, Vasan RS, O'Donnell CJ, Cowan CA. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017 04 06; 20(4):547-557.e7. PMID: 28388431.
      View in: PubMed
    5. Katz DH, Deo R, Aguilar FG, Selvaraj S, Martinez EE, Beussink-Nelson L, Kim KA, Peng J, Irvin MR, Tiwari H, Rao DC, Arnett DK, Shah SJ. Phenomapping for the Identification of Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection Fraction. J Cardiovasc Transl Res. 2017 Jun; 10(3):275-284. PMID: 28258421.
      View in: PubMed
    6. Deo R, Nallamothu BK. Learning About Machine Learning: The Promise and Pitfalls of Big Data and the Electronic Health Record. Circ Cardiovasc Qual Outcomes. 2016 Nov; 9(6):618-620. PMID: 28263936.
      View in: PubMed
    7. Deo R. Alternative Splicing, Internal Promoter, Nonsense-Mediated Decay, or All Three: Explaining the Distribution of Truncation Variants in Titin. Circ Cardiovasc Genet. 2016 Oct; 9(5):419-425. PMID: 27625338.
      View in: PubMed
    8. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo R, Chawla A, et al. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11; 166(4):841-854. PMID: 27453471; PMCID: PMC4985267 [Available on 08/11/17].
      View in: PubMed, PubMed Central
    9. Deo R. Editorial commentary: Induced pluripotent stem cell (IPSC) cardiomyocytes: My kingdom for a useful disease model! Trends Cardiovasc Med. 2016 11; 26(8):673-674. PMID: 27349929.
      View in: PubMed
    10. Deo R. Machine Learning in Medicine. Circulation. 2015 Nov 17; 132(20):1920-30. PMID: 26572668.
      View in: PubMed
    11. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo R. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406. PMID: 26473617; PMCID: PMC4720518.
      View in: PubMed, PubMed Central
    12. Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet. 2015 Apr; 8(2):343-50. PMID: 25632026; PMCID: PMC4406825.
      View in: PubMed, PubMed Central
    13. Vedantham V, Galang G, Evangelista M, Deo R, Srivastava D. RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells. Circ Res. 2015 Feb 27; 116(5):797-803. PMID: 25623957; PMCID: PMC4344860.
      View in: PubMed, PubMed Central
    14. Deo R, Musso G, Tasan M, Tang P, Poon A, Yuan C, Felix JF, Vasan RS, Beroukhim R, De Marco T, Kwok PY, MacRae CA, Roth FP. Prioritizing causal disease genes using unbiased genomic features. Genome Biol. 2014 Dec 03; 15(12):534. PMID: 25633252; PMCID: PMC4279789.
      View in: PubMed, PubMed Central
    15. Roberts JD, Longoria J, Poon A, Gollob MH, Dewland TA, Kwok PY, Olgin JE, Deo R, Marcus GM. Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation. Circ Cardiovasc Genet. 2015 Feb; 8(1):50-7. PMID: 25406240; PMCID: PMC4334693.
      View in: PubMed, PubMed Central
    16. Shah SJ, Katz DH, Selvaraj S, Burke MA, Yancy CW, Gheorghiade M, Bonow RO, Huang CC, Deo R. Phenomapping for novel classification of heart failure with preserved ejection fraction. Circulation. 2015 Jan 20; 131(3):269-79. PMID: 25398313; PMCID: PMC4302027.
      View in: PubMed, PubMed Central
    17. Mak AC, Pullinger CR, Tang LF, Wong JS, Deo R, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol. 2014 Oct; 71(10):1228-36. PMID: 25111166; PMCID: PMC4714860.
      View in: PubMed, PubMed Central
    18. Shah SJ, Katz DH, Deo R. Phenotypic spectrum of heart failure with preserved ejection fraction. Heart Fail Clin. 2014 Jul; 10(3):407-18. PMID: 24975905; PMCID: PMC4076705.
      View in: PubMed, PubMed Central
    19. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo R, Locksley RM, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013 Apr 11; 153(2):376-88. PMID: 23582327; PMCID: PMC3663598.
      View in: PubMed, PubMed Central
    20. Rozenblatt-Rosen O, Deo R, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012 Jul 26; 487(7408):491-5. PMID: 22810586; PMCID: PMC3408847.
      View in: PubMed, PubMed Central
    21. Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo R, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA. Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol. 2012 Jan 15; 14(2):209-19. PMID: 22246346; PMCID: PMC3385947.
      View in: PubMed, PubMed Central
    22. Lau FH, Deo R, Mowrer G, Caplin J, Ahfeldt T, Kaplan A, Ptaszek L, Walker JD, Rosengard BR, Cowan CA. Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue. PLoS One. 2011; 6(10):e26092. PMID: 22022522; PMCID: PMC3191160.
      View in: PubMed, PubMed Central
    23. Diep CQ, Ma D, Deo R, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 2011 Feb 03; 470(7332):95-100. PMID: 21270795; PMCID: PMC3170921.
      View in: PubMed, PubMed Central
    24. Deo R, Wilson JG, Xing C, Lawson K, Kao WH, Reich D, Tandon A, Akylbekova E, Patterson N, Mosley TH, Boerwinkle E, Taylor HA. Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans. PLoS One. 2011 Jan 24; 6(1):e14581. PMID: 21283670; PMCID: PMC3025914.
      View in: PubMed, PubMed Central
    25. Becker JR, Deo R, Werdich AA, Panàkovà D, Coy S, MacRae CA. Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish. Dis Model Mech. 2011 May; 4(3):400-10. PMID: 21245263; PMCID: PMC3097461.
      View in: PubMed, PubMed Central
    26. Deo R, MacRae CA. Clinical screening and genetic testing. Clin Lab Med. 2010 Dec; 30(4):775-84. PMID: 20832651; PMCID: PMC4308415.
      View in: PubMed, PubMed Central
    27. Deo R, MacRae CA. The zebrafish: scalable in vivo modeling for systems biology. Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun; 3(3):335-46. PMID: 20882534; PMCID: PMC3251331.
      View in: PubMed, PubMed Central
    28. Keebler ME, Deo R, Surti A, Konieczkowski D, Guiducci C, Burtt N, Buxbaum SG, Sarpong DF, Steffes MW, Wilson JG, Taylor HA, Kathiresan S. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. Circ Cardiovasc Genet. 2010 Aug; 3(4):358-64. PMID: 20570916; PMCID: PMC3074173.
      View in: PubMed, PubMed Central
    29. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010 May 26; 2(33):33ra37. PMID: 20505214; PMCID: PMC3010398.
      View in: PubMed, PubMed Central
    30. Deo R, MacRae CA. Clinical screening and genetic testing. Heart Fail Clin. 2010 Apr; 6(2):231-8. PMID: 20347791; PMCID: PMC2874821.
      View in: PubMed, PubMed Central
    31. Deo R, Hunter L, Lewis GD, Pare G, Vasan RS, Chasman D, Wang TJ, Gerszten RE, Roth FP. Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26; 6(2):e1000692. PMID: 20195502; PMCID: PMC2829050.
      View in: PubMed, PubMed Central
    32. Fejerman L, Haiman CA, Reich D, Tandon A, Deo R, John EM, Ingles SA, Ambrosone CB, Bovbjerg DH, Jandorf LH, Davis W, Ciupak G, Whittemore AS, Press MF, Ursin G, Bernstein L, Huntsman S, Henderson BE, Ziv E, Freedman ML. An admixture scan in 1,484 African American women with breast cancer. Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):3110-7. PMID: 19843668; PMCID: PMC2783219.
      View in: PubMed, PubMed Central
    33. Deo R, Roth FP. Pathways of the heart. Circ Cardiovasc Genet. 2009 Aug; 2(4):303-5. PMID: 20031600; PMCID: PMC2823807.
      View in: PubMed, PubMed Central
    34. Deo R, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, Kathiresan S, Sarpong D, Taylor HA, Wilson JG. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet. 2009 Jan; 5(1):e1000342. PMID: 19148283; PMCID: PMC2613537.
      View in: PubMed, PubMed Central
    35. Deo R, MacRae CA. The genetics of cardiomyopathies: what clinicians should know. Curr Heart Fail Rep. 2007 Dec; 4(4):229-35. PMID: 18221620.
      View in: PubMed
    36. Deo R, Patterson N, Tandon A, McDonald GJ, Haiman CA, Ardlie K, Henderson BE, Henderson SO, Reich D. A high-density admixture scan in 1,670 African Americans with hypertension. PLoS Genet. 2007 Nov; 3(11):e196. PMID: 18020707; PMCID: PMC2077893.
      View in: PubMed, PubMed Central
    37. Deo R, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J. 2004 Jan 14; 23(1):9-22. PMID: 14685275; PMCID: PMC1271659.
      View in: PubMed, PubMed Central
    38. Collavoli A, Hatcher CJ, He J, Okin D, Deo R, Basson CT. TBX5 nuclear localization is mediated by dual cooperative intramolecular signals. J Mol Cell Cardiol. 2003 Oct; 35(10):1191-5. PMID: 14519429.
      View in: PubMed
    39. Deo R, Groft CM, Rajashankar KR, Burley SK. Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer. Cell. 2002 Jan 11; 108(1):71-81. PMID: 11792322.
      View in: PubMed
    40. Deo R, Sonenberg N, Burley SK. X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4414-9. PMID: 11287654; PMCID: PMC31849.
      View in: PubMed, PubMed Central
    41. Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo R, Burley SK, Sonenberg N. Translational repression by a novel partner of human poly(A) binding protein, Paip2. Mol Cell. 2001 Jan; 7(1):205-16. PMID: 11172725.
      View in: PubMed
    42. Deo R, Bonanno JB, Sonenberg N, Burley SK. Recognition of polyadenylate RNA by the poly(A)-binding protein. Cell. 1999 Sep 17; 98(6):835-45. PMID: 10499800.
      View in: PubMed
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