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Randall Kramer, PhD

Title(s)Professor Emeritus, Cell and Tissue Biology
SchoolSchool of Dentistry
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-476-3275
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyBA1971Biochemistry
    Yale University School of MedicineMS, PhD1977Pharmacology
    University of California, IrvinePostdoctoral Fellow1980Tumor Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism regulating ErbB signaling network in head and neck cancer
    NIH R01DE022565Dec 5, 2012 - Aug 31, 2018
    Role: Principal Investigator
    SKELETAL MUSCLE STEM CELLS FOR TISSUE REPAIR
    NIH R01DE015404Aug 1, 2003 - May 31, 2009
    Role: Principal Investigator
    ADHESION AND PROLIFERATION IN ORAL CANCER PROGRESSION
    NIH P01DE013904Jun 1, 2001 - May 31, 2008
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH P30CA082103Aug 5, 1999 - May 31, 2023
    Role: Co-Investigator
    NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    NIH P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    MYOTENDINOUS JUNCTION FORMATION IN SKELETAL MUSCLE
    NIH R01DE013479Feb 1, 1999 - Jan 31, 2005
    Role: Principal Investigator
    Regulation of Survival in Head and Neck Cancer Progression
    NIH R56DE011436Apr 1, 1995 - Aug 31, 2013
    Role: Principal Investigator
    Regulation of Survival in Oral Squamous Cell Carcinoma
    NIH R01DE011436Apr 1, 1995 - Dec 31, 2009
    Role: Principal Investigator
    ADHESION AND REMODELING MECHANISMS IN GINGIVA AND BONE
    NIH P50DE010306Dec 1, 1992 - Oct 31, 1999
    Role: Co-Investigator
    ORAL CANCER--ADHESIVE INTERACTIONS DURING PROGRESSION
    NIH R01DE010564Sep 30, 1992 - Sep 29, 1997
    Role: Principal Investigator
    INTEGRIN RECEPTOR FOR LAMININ IN MALIGNANT MELANOMA
    NIH R01CA051884Apr 1, 1990 - Dec 31, 1995
    Role: Principal Investigator
    TUMOR CELL INVASION OF MICROVESSEL SUBENDOTHELIAL MATRIX
    NIH R01CA033834Feb 1, 1983 - Jan 31, 1994
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF INVASION IN ORAL CANCER
    NIH P50DE011912Jan 31, 2004
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer. Oncotarget. 2019 Sep 10; 10(52):5468-5479. Yang F, Xiao W, Liu Y, Liu R, Kramer R, Li X, Ajena Y, Baehr CM, Rojalin T, Zhang H, Lam KS. PMID: 31534631.
      View in: PubMed   Mentions:    Fields:    
    2. ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Oncogene. 2016 Mar 24; 35(12):1554-64. Humtsoe JO, Pham E, Louie RJ, Chan DA, Kramer RH. PMID: 26073080.
      View in: PubMed   Mentions:
    3. Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. J Calif Dent Assoc. 2012 Dec; 40(12):939-43. Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS. PMID: 23362666.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells. Exp Cell Res. 2012 Feb 15; 318(4):379-90. Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, Kramer RH. PMID: 22154512.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    5. Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis. Mol Cancer Res. 2010 Feb; 8(2):170-82. Zuo J, Ishikawa T, Boutros S, Xiao Z, Humtsoe JO, Kramer RH. PMID: 20145039.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    6. Sdc1 negatively modulates carcinoma cell motility and invasion. Exp Cell Res. 2010 Apr 01; 316(6):951-65. Ishikawa T, Kramer RH. PMID: 20036233.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    7. Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Oncogene. 2010 Feb 25; 29(8):1214-26. Humtsoe JO, Kramer RH. PMID: 19935697.
      View in: PubMed   Mentions:
    8. Analysis of human muscle stem cells reveals a differentiation-resistant progenitor cell population expressing Pax7 capable of self-renewal. Dev Dyn. 2009 Jan; 238(1):138-49. Pawlikowski B, Lee L, Zuo J, Kramer RH. PMID: 19097049.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol. 2008 Sep; 84(3):701-12. Gorfu G, Virtanen I, Hukkanen M, Lehto VP, Rousselle P, Kenne E, Lindbom L, Kramer R, Tryggvason K, Patarroyo M. PMID: 18523231.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    10. Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer. Technol Cancer Res Treat. 2007 Oct; 6(5):403-12. El-Sayed I, Huang X, Macheret F, Humstoe JO, Kramer R, El-Sayed M. PMID: 17877428.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Exp Cell Res. 2008 Jan 15; 314(2):377-86. Onishi A, Chen Q, Humtsoe JO, Kramer RH. PMID: 17961551.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    12. Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. J Biol Chem. 2005 Oct 28; 280(43):36037-46. Jethanandani P, Kramer RH. PMID: 16129691.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    13. Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev. 2005 Jan; 24(1):35-45. Kramer RH, Shen X, Zhou H. PMID: 15785871.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    14. Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. J Biol Chem. 2005 Mar 18; 280(11):10624-35. Zhou H, Kramer RH. PMID: 15611088.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    15. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol. 2004 Oct; 165(4):1315-29. Shen X, Kramer RH. PMID: 15466396.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    16. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun. 2004 Mar 19; 315(4):850-6. Chen Q, Lipkina G, Song Q, Kramer RH. PMID: 14985090.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Regulation of alpha7 integrin expression during muscle differentiation. J Biol Chem. 2003 Dec 12; 278(50):49780-8. Xiao J, Jethanandani P, Ziober BL, Kramer RH. PMID: 14525975.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    18. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 2003 Jul; 313(1):93-105. Ferguson JW, Thoma BS, Mikesh MF, Kramer RH, Bennett KL, Purchio A, Bellard BJ, LeBaron RG. PMID: 12838408.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    19. The beta1 cytoplasmic domain regulates the laminin-binding specificity of the alpha7X1 integrin. Mol Biol Cell. 2003 Sep; 14(9):3507-18. Yeh MG, Ziober BL, Liu B, Lipkina G, Vizirianakis IS, Kramer RH. PMID: 12972542.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    20. Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells. Int J Oncol. 2002 Jul; 21(1):135-44. Vizirianakis IS, Chen YQ, Kantak SS, Tsiftsoglou AS, Kramer RH. PMID: 12063560.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
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