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Randall Kramer, PhD

Title(s)Professor Emeritus, Cell and Tissue Biology
SchoolSchool of Dentistry
Phone415-476-3275
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyBA1971Biochemistry
    Yale University School of MedicineMS, PhD1977Pharmacology
    University of California, IrvinePostdoctoral Fellow1980Tumor Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism regulating ErbB signaling network in head and neck cancer
    NIH/NIDCR R01DE022565Dec 5, 2012 - Nov 30, 2016
    Role: Principal Investigator
    SKELETAL MUSCLE STEM CELLS FOR TISSUE REPAIR
    NIH/NIDCR R01DE015404Aug 1, 2003 - May 31, 2009
    Role: Principal Investigator
    ADHESION AND PROLIFERATION IN ORAL CANCER PROGRESSION
    NIH/NIDCR P01DE013904Jun 1, 2001 - May 31, 2008
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH/NCI P30CA082103Aug 5, 1999 - May 31, 2023
    Role: Co-Investigator
    NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    NIH/NIDCR P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    MYOTENDINOUS JUNCTION FORMATION IN SKELETAL MUSCLE
    NIH/NIDCR R01DE013479Feb 1, 1999 - Jan 31, 2005
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF INVASION IN ORAL CANCER
    NIH/NIDCR P50DE011912Sep 30, 1996 - Jan 31, 2004
    Role: Principal Investigator
    Regulation of Survival in Head and Neck Cancer Progression
    NIH/NIDCR R56DE011436Apr 1, 1995 - Aug 31, 2013
    Role: Principal Investigator
    Regulation of Survival in Oral Squamous Cell Carcinoma
    NIH/NIDCR R01DE011436Apr 1, 1995 - Dec 31, 2009
    Role: Principal Investigator
    ADHESION AND REMODELING MECHANISMS IN GINGIVA AND BONE
    NIH/NIDCR P50DE010306Dec 1, 1992 - Oct 31, 1999
    Role: Co-Investigator
    ORAL CANCER--ADHESIVE INTERACTIONS DURING PROGRESSION
    NIH/NIDCR R01DE010564Sep 30, 1992 - Sep 29, 1997
    Role: Principal Investigator
    INTEGRIN RECEPTOR FOR LAMININ IN MALIGNANT MELANOMA
    NIH/NCI R01CA051884Apr 1, 1990 - Dec 31, 1995
    Role: Principal Investigator
    TUMOR CELL INVASION OF MICROVESSEL SUBENDOTHELIAL MATRIX
    NIH/NCI R01CA033834Feb 1, 1983 - Jan 31, 1994
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ozeki N, Mogi M, Yamaguchi H, Hiyama T, Kawai R, Hase N, Nakata K, Nakamura H, Kramer RH. Differentiation of human skeletal muscle stem cells into odontoblasts is dependent on induction of a1 integrin expression. J Biol Chem. 2014 May 16; 289(20):14380-91. PMID: 24692545; PMCID: PMC4022904.
      View in: PubMed, PubMed Central
    2. Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS. Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. J Calif Dent Assoc. 2012 Dec; 40(12):939-43. PMID: 23362666; PMCID: PMC4562383.
      View in: PubMed, PubMed Central
    3. Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, Kramer RH. Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells. Exp Cell Res. 2012 Feb 15; 318(4):379-90. PMID: 22154512.
      View in: PubMed
    4. Zuo J, Ishikawa T, Boutros S, Xiao Z, Humtsoe JO, Kramer RH. Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis. Mol Cancer Res. 2010 Feb; 8(2):170-82. PMID: 20145039.
      View in: PubMed
    5. Ishikawa T, Kramer RH. Sdc1 negatively modulates carcinoma cell motility and invasion. Exp Cell Res. 2010 Apr 01; 316(6):951-65. PMID: 20036233; PMCID: PMC2834805.
      View in: PubMed, PubMed Central
    6. Pawlikowski B, Lee L, Zuo J, Kramer RH. Analysis of human muscle stem cells reveals a differentiation-resistant progenitor cell population expressing Pax7 capable of self-renewal. Dev Dyn. 2009 Jan; 238(1):138-49. PMID: 19097049; PMCID: PMC2799339.
      View in: PubMed, PubMed Central
    7. Gorfu G, Virtanen I, Hukkanen M, Lehto VP, Rousselle P, Kenne E, Lindbom L, Kramer R, Tryggvason K, Patarroyo M. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol. 2008 Sep; 84(3):701-12. PMID: 18523231.
      View in: PubMed
    8. El-Sayed I, Huang X, Macheret F, Humstoe JO, Kramer R, El-Sayed M. Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer. Technol Cancer Res Treat. 2007 Oct; 6(5):403-12. PMID: 17877428.
      View in: PubMed
    9. Onishi A, Chen Q, Humtsoe JO, Kramer RH. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Exp Cell Res. 2008 Jan 15; 314(2):377-86. PMID: 17961551; PMCID: PMC2766263.
      View in: PubMed, PubMed Central
    10. Ozeki N, Jethanandani P, Nakamura H, Ziober BL, Kramer RH. Modulation of satellite cell adhesion and motility following BMP2-induced differentiation to osteoblast lineage. Biochem Biophys Res Commun. 2007 Feb 02; 353(1):54-9. PMID: 17166482; PMCID: PMC1868413.
      View in: PubMed, PubMed Central
    11. Ozeki N, Lim M, Yao CC, Tolar M, Kramer RH. alpha7 integrin expressing human fetal myogenic progenitors have stem cell-like properties and are capable of osteogenic differentiation. Exp Cell Res. 2006 Dec 10; 312(20):4162-80. PMID: 17054947; PMCID: PMC2766282.
      View in: PubMed, PubMed Central
    12. Jethanandani P, Kramer RH. Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. J Biol Chem. 2005 Oct 28; 280(43):36037-46. PMID: 16129691.
      View in: PubMed
    13. Kramer RH, Shen X, Zhou H. Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev. 2005 Jan; 24(1):35-45. PMID: 15785871.
      View in: PubMed
    14. Zhou H, Kramer RH. Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. J Biol Chem. 2005 Mar 18; 280(11):10624-35. PMID: 15611088.
      View in: PubMed
    15. Shen X, Kramer RH. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol. 2004 Oct; 165(4):1315-29. PMID: 15466396; PMCID: PMC1618631.
      View in: PubMed, PubMed Central
    16. Chen Q, Lipkina G, Song Q, Kramer RH. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun. 2004 Mar 19; 315(4):850-6. PMID: 14985090.
      View in: PubMed
    17. Xiao J, Jethanandani P, Ziober BL, Kramer RH. Regulation of alpha7 integrin expression during muscle differentiation. J Biol Chem. 2003 Dec 12; 278(50):49780-8. PMID: 14525975.
      View in: PubMed
    18. Ferguson JW, Thoma BS, Mikesh MF, Kramer RH, Bennett KL, Purchio A, Bellard BJ, LeBaron RG. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 2003 Jul; 313(1):93-105. PMID: 12838408.
      View in: PubMed
    19. Yeh MG, Ziober BL, Liu B, Lipkina G, Vizirianakis IS, Kramer RH. The beta1 cytoplasmic domain regulates the laminin-binding specificity of the alpha7X1 integrin. Mol Biol Cell. 2003 Sep; 14(9):3507-18. PMID: 12972542.
      View in: PubMed
    20. Kim TW, Chen Q, Shen X, Regezi JA, Ramos DM, Tanaka H, Jordan RC, Kramer RH. Oral mucosal carcinogenesis in SENCAR mice. Anticancer Res. 2002 Sep-Oct; 22(5):2733-40. PMID: 12529989.
      View in: PubMed
    21. Vizirianakis IS, Chen YQ, Kantak SS, Tsiftsoglou AS, Kramer RH. Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells. Int J Oncol. 2002 Jul; 21(1):135-44. PMID: 12063560.
      View in: PubMed
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