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Raphael Meier, MD, PhD

Title(s)Assistant Professor, Surgery
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of Geneva, SwitzerlandClinical Fellowship2017Abdominal Surgery
    University of Geneva, SwitzerlandResidency2015Surgery (Board Certification)
    University of Geneva, SwitzerlandM.D.2007School of Medicine
    Collapse Awards and Honors
    Swiss Association for Laparoscopic and Thoracoscopic Surgery2018Zollikofer Award
    International Pancreas and Islet Transplant Association (IPITA)2015Derek Gray Distinguished Traveling Scholarship Award
    University Hospital of Geneva2015Gilles Mentha Award, Basic Sciences
    University Hospital of Geneva2015Marc-Claude Marti Award
    Geneva University and Medical School2014Geneva University best MD-PHD thesis award (Arditi award)

    Collapse Overview 
    Collapse Overview
    Raphael P. H. Meier, M.D., Ph.D. is a surgeon and researcher in the Department of Surgery and Transplant Surgery at UCSF. Dr. Meier's research is focused on the development of Mesenchymal Stem Cell transplantation as a therapeutic modality to deliver anti-inflammatory cytokines to treat liver fibrosis and nonalcoholic steatohepatitis. Another part of his research focuses on the development of new strategies to improve outcomes after Islet Transplantation for the treatment of type I diabetes.

    Collapse Research 
    Collapse Research Activities and Funding
    Mesenchymal stem cells for the treatment of steatohepatitis-induced liver failure
    Bridge to academic career, Swiss Association for Research in Surgery BRIDGE-2017Jun 1, 2017
    Role: Principal Investigator
    Human mesenchymal stem cells for the treatment of alcoholic hepatitis
    Private Foundation of the Geneva University Hospitals STARTER-RS1-18May 10, 2016 - May 31, 2019
    Role: Principal Investigator
    Genetic determinants of metabolic syndrome components in pancreas donors for islet transplantation
    Geneva University Hospital PRD 22-2013-IMay 7, 2013
    Role: Principal Investigator
    Risk factors for atypical femur fracture during bisphosphonate therapy
    Geneva University Hospitals PRD 9-I-2012May 3, 2012 - Dec 15, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ostermann S, Morel P, Chale JJ, Bucher P, Konrad B, Meier RPH, Ris F, Schiffer ERC. Randomized Controlled Trial of Enhanced Recovery Program Dedicated to Elderly Patients After Colorectal Surgery. Dis Colon Rectum. 2019 Jul 12. PMID: 31318772.
      View in: PubMed
    2. Muller YD, Meier RPH. Targeting laminin 511, a new pathway to promote organ tolerance? Transplantation. 2019 Apr 25. PMID: 31033650.
      View in: PubMed
    3. Meier RPH, Meyer J, Montanari E, Lacotte S, Balaphas A, Muller YD, Clément S, Negro F, Toso C, Morel P, Buhler LH. Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner. Int J Mol Sci. 2019 Mar 14; 20(6). PMID: 30875826.
      View in: PubMed
    4. Meier RPH, Andrey DO, Sun P, Niclauss N, Bédat B, Demuylder-Mischler S, Borot S, Benhamou PY, Wojtusciszyn A, Buron F, Pernin N, Muller YD, Bosco D, van Delden C, Berney T. Pancreas preservation fluid microbial contamination is associated with poor islet isolation outcomes - a multi-centre cohort study. Transpl Int. 2018 08; 31(8):917-929. PMID: 29603452.
      View in: PubMed
    5. Schuetz C, Anazawa T, Cross SE, Labriola L, Meier RPH, Redfield RR, Scholz H, Stock PG, Zammit NW. ß Cell Replacement Therapy: The Next 10 Years. Transplantation. 2018 02; 102(2):215-229. PMID: 28885496.
      View in: PubMed
    6. Montanari E, Pimenta J, Szabó L, Noverraz F, Passemard S, Meier RPH, Meyer J, Sidibe J, Thomas A, Schuurman HJ, Gerber-Lemaire S, Gonelle-Gispert C, Buhler LH. Beneficial Effects of Human Mesenchymal Stromal Cells on Porcine Hepatocyte Viability and Albumin Secretion. J Immunol Res. 2018; 2018:1078547. PMID: 29577046.
      View in: PubMed
    7. Meier RPH, Muller YD, Balaphas A, Morel P, Pascual M, Seebach JD, Buhler LH. Xenotransplantation: back to the future? Transpl Int. 2018 05; 31(5):465-477. PMID: 29210109.
      View in: PubMed
    8. Montanari E, Meier RPH, Mahou R, Seebach JD, Wandrey C, Gerber-Lemaire S, Buhler LH, Gonelle-Gispert C. Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice. Stem Cell Res Ther. 2017 09 29; 8(1):199. PMID: 28962589.
      View in: PubMed
    9. Meier RPH, Piller V, Hagen ME, Joliat C, Buchs JB, Nastasi A, Ruttimann R, Buchs NC, Moll S, Vallée JP, Lazeyras F, Morel P, Bühler L. Intra-Abdominal Cooling System Limits Ischemia-Reperfusion Injury During Robot-Assisted Renal Transplantation. Am J Transplant. 2018 01; 18(1):53-62. PMID: 28637093.
      View in: PubMed
    10. Oldani G, Peloso A, Lacotte S, Meier R, Toso C. Xenogeneic chimera-Generated by blastocyst complementation-As a potential unlimited source of recipient-tailored organs. Xenotransplantation. 2017 07; 24(4). PMID: 28736957.
      View in: PubMed
    11. Meier R, Fournier I, Toso C, Berney T, Bednarkiewicz M. Surgical Repair of a Living-Donor Kidney Graft Artery Kink by a Postanastomotic External Iliac Artery Rotation and Reanastomosis. Ann Vasc Surg. 2017 Oct; 44:414.e5-414.e9. PMID: 28479435.
      View in: PubMed
    12. Meier RP, Montanari E, Morel P, Pimenta J, Schuurman HJ, Wandrey C, Gerber-Lemaire S, Mahou R, Bühler LH. Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications. Methods Mol Biol. 2017; 1506:259-271. PMID: 27830559.
      View in: PubMed
    13. Raffoul T, Balaphas A, Meier RP, Hansen C, Puppa G, Frossard JL, Morel P, Bühler LH. [Cystic lesions of the pancreas from the general practitioner's point of view]. Rev Med Suisse. 2016 Jun 15; 12(523):1174-9. PMID: 27487622.
      View in: PubMed
    14. Balaphas A, Belfontali V, Ris F, Lanitis A, Meier RP, Amram ML, Roth A, Huber O, Berney T, Morel P. [Management of peritoneal carcinomatosis with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy]. Rev Med Suisse. 2016 Jun 15; 12(523):1190-4. PMID: 27487625.
      View in: PubMed
    15. Meier R, Sun P, Gerber-Lemaire S, Berney T, Muller Y.Pancreatic islet transplantation into the bone marrow. Cell R4. 2016; 4(3):e2089.
    16. Niclauss N, Meier R, Bédat B, Berishvili E, Berney T. Beta-Cell Replacement: Pancreas and Islet Cell Transplantation. Endocr Dev. 2016; 31:146-62. PMID: 26824893.
      View in: PubMed
    17. Lavallard V, Armanet M, Parnaud G, Meyer J, Barbieux C, Montanari E, Meier R, Morel P, Berney T, Bosco D. Cell rearrangement in transplanted human islets. FASEB J. 2016 Feb; 30(2):748-60. PMID: 26534832.
      View in: PubMed
    18. Meier RPH, Navarro-Alvarez N, Morel P, Schuurman HJ, Strom S, Bühler LH. Current status of hepatocyte xenotransplantation. Int J Surg. 2015 Nov; 23(Pt B):273-279. PMID: 26361861.
      View in: PubMed
    19. Meier RP, Toso C, Terraz S, Breguet R, Berney T, Andres A, Jannot AS, Rubbia-Brandt L, Morel P, Majno PE. Improved liver function after portal vein embolization and an elective right hepatectomy. HPB (Oxford). 2015 Nov; 17(11):1009-18. PMID: 26345460.
      View in: PubMed
    20. Lejmi E, Perriraz N, Clément S, Morel P, Baertschiger R, Christofilopoulos P, Meier R, Bosco D, Bühler LH, Gonelle-Gispert C. Inflammatory Chemokines MIP-1d and MIP-3a Are Involved in the Migration of Multipotent Mesenchymal Stromal Cells Induced by Hepatoma Cells. Stem Cells Dev. 2015 May 15; 24(10):1223-35. PMID: 25579056.
      View in: PubMed
    21. Giovannoni L, Muller YD, Lacotte S, Parnaud G, Borot S, Meier RP, Lavallard V, Bédat B, Toso C, Daubeuf B, Elson G, Shang L, Morel P, Kosco-Vilbois M, Bosco D, Berney T. Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade. Transplantation. 2015 Jan; 99(1):29-35. PMID: 25340601.
      View in: PubMed
    22. Meier RP, de Saussure WO, Orci LA, Gutzwiller EM, Morel P, Ris F, Schwenter F. Clinical outcome in acute small bowel obstruction after surgical or conservative management. World J Surg. 2014 Dec; 38(12):3082-8. PMID: 25145820.
      View in: PubMed
    23. Meier RP, Mahou R, Morel P, Meyer J, Montanari E, Muller YD, Christofilopoulos P, Wandrey C, Gonelle-Gispert C, Bühler LH. Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice. J Hepatol. 2015 Mar; 62(3):634-41. PMID: 25450712.
      View in: PubMed
    24. Meier RP, Sert I, Morel P, Muller YD, Borot S, Badet L, Toso C, Bosco D, Berney T. Islet of Langerhans isolation from pediatric and juvenile donor pancreases. Transpl Int. 2014 Sep; 27(9):949-55. PMID: 24890668.
      View in: PubMed
    25. Meier RP, Muller YD, Gutzwiller EM, Spahr L, Negro F, Krause KH, Schaller K, Wandrey C, Sgroi A, Morel P, Bühler LH. [Cell transplantation: current treatments and future prospects]. Rev Med Suisse. 2014 Jun 18; 10(435):1350-5. PMID: 25051598.
      View in: PubMed
    26. Meier RP, Seebach JD, Morel P, Mahou R, Borot S, Giovannoni L, Parnaud G, Montanari E, Bosco D, Wandrey C, Berney T, Bühler LH, Muller YD. Survival of free and encapsulated human and rat islet xenografts transplanted into the mouse bone marrow. PLoS One. 2014; 9(3):e91268. PMID: 24625569.
      View in: PubMed
    27. Mahou R, Meier RPH, Bühler LH, Wandrey C. Alginate-Poly(ethylene glycol) Hybrid Microspheres for Primary Cell Microencapsulation. Materials (Basel). 2014 Jan 09; 7(1):275-286. PMID: 28788456.
      View in: PubMed
    28. Orci LA, Meier RP, Morel P, Staszewicz W, Toso C. Systematic review and meta-analysis of percutaneous subclavian vein puncture versus surgical venous cutdown for the insertion of a totally implantable venous access device. Br J Surg. 2014 Jan; 101(2):8-16. PMID: 24276950.
      View in: PubMed
    29. Borot S, Crowe LA, Parnaud G, Ris F, Meier R, Giovannoni L, Müller YD, Lacotte S, Morel P, Toso C, Bosco D, Vallee JP, Berney T. Quantification of islet loss and graft functionality during immune rejection by 3-tesla MRI in a rat model. Transplantation. 2013 Sep 15; 96(5):438-44. PMID: 23902991.
      View in: PubMed
    30. Meier RP, Müller YD, Morel P, Gonelle-Gispert C, Bühler LH. Transplantation of mesenchymal stem cells for the treatment of liver diseases, is there enough evidence? Stem Cell Res. 2013 Nov; 11(3):1348-64. PMID: 24090934.
      View in: PubMed
    31. Mahou R, Kollarikova G, Gonelle-Gispert C, Meier R, Schmitt F, Tran N, Dufresne M, Lacik I, Bühler L, Juillerat-Jeanneret L, Legallais C, Christine Wandrey C.Combined Electrostatic and Covalent Polymer Networks for Cell Microencapsulation. Macromolecular Symposia. 2013; 329(1):49-57.
    32. Muller YD, Meier RP, Bromberg JS, Bühler LH. Literature Watch: implications for transplantation. Am J Transplant. 2013 Jun; 13(6):1377. PMID: 23721549.
      View in: PubMed
    33. Meier RP, Rizzoli R, Peter RE. Are bisphosphonates associated with an increased risk of atypical femoral fractures as a class?-Reply. JAMA Intern Med. 2013 Jan 14; 173(1):80. PMID: 23318594.
      View in: PubMed
    34. Meier RP, Ing Lorenzini K, Uebelhart B, Stern R, Peter RE, Rizzoli R. Atypical femoral fracture following bisphosphonate treatment in a woman with osteogenesis imperfecta--a case report. Acta Orthop. 2012 Oct; 83(5):548-50. PMID: 22998530.
      View in: PubMed
    35. Meier RP, Perneger TV, Stern R, Rizzoli R, Peter RE. Increasing occurrence of atypical femoral fractures associated with bisphosphonate use. Arch Intern Med. 2012 Jun 25; 172(12):930-6. PMID: 22732749.
      View in: PubMed
    36. Ing Lorenzinit K, Meier R, Suva D, Dayer P, Desmeules J, Peter R. [Atypical femoral fracture associated with the use of bisphosphonates, an adverse drug reaction not to be missed]. Rev Med Suisse. 2012 Jun 06; 8(344):1238-42. PMID: 22730621.
      View in: PubMed
    37. Borot S, Niclauss N, Wojtusciszyn A, Brault C, Demuylder-Mischler S, Müller Y, Giovannoni L, Parnaud G, Meier R, Badet L, Bayle F, Frimat L, Kessler L, Morelon E, Penfornis A, Thivolet C, Toso C, Morel P, Bosco D, Colin C, Benhamou PY, Berney T. Impact of the number of infusions on 2-year results of islet-after-kidney transplantation in the GRAGIL network. Transplantation. 2011 Nov 15; 92(9):1031-8. PMID: 21926944.
      View in: PubMed
    38. Parnaud G, Gonelle-Gispert C, Morel P, Giovannoni L, Muller YD, Meier R, Borot S, Berney T, Bosco D. Cadherin engagement protects human ß-cells from apoptosis. Endocrinology. 2011 Dec; 152(12):4601-9. PMID: 21990317.
      View in: PubMed
    39. Lorenzo PI, Jimenez Moreno CM, Delgado I, Cobo-Vuilleumier N, Meier R, Gomez-Izquierdo L, Berney T, Garcia-Carbonero R, Rojas A, Gauthier BR. Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors. Histochem Cell Biol. 2011 Nov; 136(5):595-607. PMID: 21932072.
      View in: PubMed
    40. Muller YD, Golshayan D, Ehirchiou D, Wyss JC, Giovannoni L, Meier R, Serre-Beinier V, Puga Yung G, Morel P, Bühler LH, Seebach JD. Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells. Diabetes. 2011 Sep; 60(9):2331-40. PMID: 21752956; PMCID: PMC3161310.
    41. Schwenter F, Dominguez S, Meier R, Oulhaci-de Saussure W, Platon A, Gervaz P, Morel P. [Acute small bowel obstruction: conservative or surgical treatment?]. Rev Med Suisse. 2011 Jun 22; 7(300):1341-4, 1346-7. PMID: 21815533.
      View in: PubMed
    42. Ris F, Niclauss N, Morel P, Demuylder-Mischler S, Muller Y, Meier R, Genevay M, Bosco D, Berney T. Islet autotransplantation after extended pancreatectomy for focal benign disease of the pancreas. Transplantation. 2011 Apr 27; 91(8):895-901. PMID: 21372755.
      View in: PubMed
    43. Niclauss N, Bosco D, Morel P, Demuylder-Mischler S, Brault C, Milliat-Guittard L, Colin C, Parnaud G, Muller YD, Giovannoni L, Meier R, Toso C, Badet L, Benhamou PY, Berney T. Influence of donor age on islet isolation and transplantation outcome. Transplantation. 2011 Feb 15; 91(3):360-6. PMID: 21344706.
      View in: PubMed
    44. Meier RP, Toso C, Volonte F, Mentha G. Splenic rupture after colonoscopy. Am J Emerg Med. 2011 Feb; 29(2):241.e1-2. PMID: 20825894.
      View in: PubMed