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Rich Sievers

TitleSpecialist
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-476-2600
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    Collapse Biography 
    Collapse Awards and Honors
    UCSF2010Great People Award

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    Research Techniques:

    Developed the ischemia-reflow model in the rat which characterized the snare loop occlusion of the left coronary artery. By using the rat, this technique resulted in lowered costs and higher throughput with pharmaceutical interventions. (see articles below)

    Pioneered a technique for in vivo gene therapy transfer directly into the AV node. We have extended this knowledge to include the feasibility for a therapeutic role for cell transplantation and gene transfer in myocardial repair.

    Developed a chronic model in the rat to assess the effects of pharmaceuticals on left ventricular remodeling.

    Developed a closed-chest cell injection technique into mouse myocardium guided by high-resolution echocardiography. The use of this technique will allow more precise cellular implantation into the mouse/rat myocardium by accurately guiding injections to desired locations, confirming successful implantation of stem cells, in a clinically relevant time frame.

    Developed the first integrative physiologic model to reproducibly study Flow-mediated dilation in living rats. This approach demonstrates that the physiology of rodent vascular reactivity is concordant with that of humans, validating its use for the study of therapeutic modulators of vascular function.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Le LV, Mohindra P, Fang Q, Sievers R, Mkrtschjan MA, Solis C, Safranek CW, Russell B, Lee RJ, Desai TA. Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction. Biomaterials. 2018 Jul; 169:11-21. PMID: 29631164.
      View in: PubMed
    2. Geng X, Hwang J, Ye J, Shih H, Coulter B, Naudin C, Jun K, Sievers R, Yeghiazarians Y, Lee RJ, Boyle AJ. Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling. Am J Cardiovasc Dis. 2017; 7(3):72-82. PMID: 28695053.
      View in: PubMed
    3. Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers R, Schick SF, Glantz SA, Springer ML. One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function. J Am Heart Assoc. 2016 Jul 27; 5(8). PMID: 27464788.
      View in: PubMed
    4. Nazer B, Salgaonkar V, Diederich CJ, Jones PD, Duggirala S, Tanaka Y, Ng B, Sievers R, Gerstenfeld EP. Epicardial Catheter Ablation Using High-Intensity Ultrasound: Validation in a Swine Model. Circ Arrhythm Electrophysiol. 2015 Dec; 8(6):1491-7. PMID: 26546345.
      View in: PubMed
    5. Tanaka Y, Rahmutula D, Duggirala S, Nazer B, Fang Q, Olgin J, Sievers R, Gerstenfeld EP. Diffuse fibrosis leads to a decrease in unipolar voltage: Validation in a swine model of premature ventricular contraction-induced cardiomyopathy. Heart Rhythm. 2016 Feb; 13(2):547-54. PMID: 26416621.
      View in: PubMed
    6. Ye J, Gaur M, Zhang Y, Sievers R, Woods BJ, Aurigui J, Bernstein HS, Yeghiazarians Y. Treatment with hESC-Derived Myocardial Precursors Improves Cardiac Function after a Myocardial Infarction. PLoS One. 2015; 10(7):e0131123. PMID: 26230835; PMCID: PMC4521814.
    7. Yu J, Wu YK, Gu Y, Fang Q, Sievers R, Ding CH, Olgin JE, Lee RJ. Immuno-modification of enhancing stem cells targeting for myocardial repair. J Cell Mol Med. 2015 Jul; 19(7):1483-91. PMID: 25904069; PMCID: PMC4511347.
    8. Nguyen J, Sievers R, Motion JP, Kivimäe S, Fang Q, Lee RJ. Delivery of lipid micelles into infarcted myocardium using a lipid-linked matrix metalloproteinase targeting peptide. Mol Pharm. 2015 Apr 06; 12(4):1150-7. PMID: 25642730.
      View in: PubMed
    9. Tanaka Y, Genet M, Chuan Lee L, Martin AJ, Sievers R, Gerstenfeld EP. Utility of high-resolution electroanatomic mapping of the left ventricle using a multispline basket catheter in a swine model of chronic myocardial infarction. Heart Rhythm. 2015 Jan; 12(1):144-54. PMID: 25173890.
      View in: PubMed
    10. Pinney JR, Du KT, Ayala P, Fang Q, Sievers R, Chew P, Delrosario L, Lee RJ, Desai TA. Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction. Biomaterials. 2014 Oct; 35(31):8820-8828. PMID: 25047625; PMCID: PMC4144416.
    11. Pinnamaneni K, Sievers R, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML. Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function. Nicotine Tob Res. 2014 May; 16(5):584-90. PMID: 24302638; PMCID: PMC3977486.
    12. Boyle AJ, Hwang J, Ye J, Shih H, Jun K, Zhang Y, Fang Q, Sievers R, Yeghiazarians Y, Lee RJ. The effects of aging on apoptosis following myocardial infarction. Cardiovasc Ther. 2013 Dec; 31(6):e102-10. PMID: 24279384; PMCID: PMC3895658.
    13. Mihardja SS, Gonzales JA, Gao D, Sievers R, Fang Q, Stillson CA, Yu J, Peng M, Lee RJ. The effect of a peptide-modified thermo-reversible methylcellulose on wound healing and LV function in a chronic myocardial infarction rodent model. Biomaterials. 2013 Nov; 34(35):8869-77. PMID: 23895998.
      View in: PubMed
    14. Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers R, Lee RJ, Springer ML. Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants. PLoS One. 2013; 8(4):e61413. PMID: 23630585; PMCID: PMC3632611.
    15. Chen Q, Sievers R, Varga M, Kharait S, Haddad DJ, Patton AK, Delany CS, Mutka SC, Blonder JP, Dubé GP, Rosenthal GJ, Springer ML. Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo. J Appl Physiol (1985). 2013 Mar 15; 114(6):752-60. PMID: 23349456; PMCID: PMC3615603.
    16. Ye J, Boyle AJ, Shih H, Sievers R, Wang ZE, Gormley M, Yeghiazarians Y. CD45-positive cells are not an essential component in cardiosphere formation. Cell Tissue Res. 2013 Jan; 351(1):201-5. PMID: 23064904.
      View in: PubMed
    17. Angeli FS, Zhang Y, Sievers R, Jun K, Yim S, Boyle A, Yeghiazarians Y. Injection of human bone marrow and mononuclear cell extract into infarcted mouse hearts results in functional improvement. Open Cardiovasc Med J. 2012; 6:38-43. PMID: 22550548; PMCID: PMC3339429.
    18. Koskenvuo JW, Sievers R, Zhang Y, Angeli FS, Lee B, Shih H, Ye J, Boyle AJ, Yeghiazarians Y. Fractionation of mouse bone-marrow cells limits functional efficacy in non-reperfused mouse model of acute myocardial infarction. Ann Med. 2012 Dec; 44(8):829-35. PMID: 22494088.
      View in: PubMed
    19. Ye J, Boyle A, Shih H, Sievers R, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS One. 2012; 7(1):e30329. PMID: 22272337; PMCID: PMC3260268.
    20. Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers R, Grossman W, Yeghiazarians Y, Springer ML. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. J Tissue Sci Eng. 2011 Nov 18; S3. PMID: 22675670.
      View in: PubMed
    21. Yeghiazarians Y, Gaur M, Zhang Y, Sievers R, Ritner C, Prasad M, Boyle A, Bernstein HS. Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition. Cytotherapy. 2012 Feb; 14(2):223-31. PMID: 22040108; PMCID: PMC3270940.
    22. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers R, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med. 2011 Sep 14; 3(100):100ra90. PMID: 21918107; PMCID: PMC3350804.
    23. Boyle AJ, Yeghiazarians Y, Shih H, Hwang J, Ye J, Sievers R, Zheng D, Palasubramaniam J, Palasubramaniam D, Karschimkus C, Whitbourn R, Jenkins A, Wilson AM. Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man. J Transl Med. 2011 Sep 12; 9:150. PMID: 21910857; PMCID: PMC3180393.
    24. Mirsky R, Jahn S, Koskenvuo JW, Sievers R, Yim SM, Ritner C, Bernstein HS, Angeli FS, Boyle AJ, De Marco T, Yeghiazarians Y. Treatment of pulmonary arterial hypertension with circulating angiogenic cells. Am J Physiol Lung Cell Mol Physiol. 2011 Jul; 301(1):L12-9. PMID: 21398496.
      View in: PubMed
    25. Boyle AJ, Shih H, Hwang J, Ye J, Lee B, Zhang Y, Kwon D, Jun K, Zheng D, Sievers R, Angeli F, Yeghiazarians Y, Lee R. Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy. Exp Gerontol. 2011 Jul; 46(7):549-59. PMID: 21377520; PMCID: PMC3104129.
    26. Gaur M, Ritner C, Sievers R, Pedersen A, Prasad M, Bernstein HS, Yeghiazarians Y. Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes. Cytotherapy. 2010 Oct; 12(6):807-17. PMID: 20586669; PMCID: PMC2946443.
    27. Zhang Y, Sievers R, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovasc Pathol. 2011 Jul-Aug; 20(4):204-12. PMID: 20667749.
      View in: PubMed
    28. Yu J, Du KT, Fang Q, Gu Y, Mihardja SS, Sievers R, Wu JC, Lee RJ. The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials. 2010 Sep; 31(27):7012-20. PMID: 20566215.
      View in: PubMed
    29. Mihardja SS, Gao D, Sievers R, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ. Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PLoS One. 2010 Apr 28; 5(4):e10384. PMID: 20442783; PMCID: PMC2860995.
    30. Huang NF, Lam A, Fang Q, Sievers R, Li S, Lee RJ. Bone marrow-derived mesenchymal stem cells in fibrin augment angiogenesis in the chronically infarcted myocardium. Regen Med. 2009 Jul; 4(4):527-38. PMID: 19580402; PMCID: PMC2778008.
    31. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers R, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009 Jul; 17(7):1250-6. PMID: 19384293; PMCID: PMC2835212.
    32. Yu J, Christman KL, Chin E, Sievers R, Saeed M, Lee RJ. Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. J Thorac Cardiovasc Surg. 2009 Jan; 137(1):180-7. PMID: 19154923.
      View in: PubMed
    33. Yu J, Gu Y, Du KT, Mihardja S, Sievers R, Lee RJ. The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model. Biomaterials. 2009 Feb; 30(5):751-6. PMID: 19010528.
      View in: PubMed
    34. Mihardja SS, Sievers R, Lee RJ. The effect of polypyrrole on arteriogenesis in an acute rat infarct model. Biomaterials. 2008 Nov; 29(31):4205-10. PMID: 18678406; PMCID: PMC2572870.
    35. Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers R, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol. 2008 Sep; 28(9):1614-20. PMID: 18511699.
      View in: PubMed
    36. Heiss C, Sievers R, Amabile N, Momma TY, Chen Q, Natarajan S, Yeghiazarians Y, Springer ML. In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H1086-93. PMID: 18055528.
      View in: PubMed
    37. Takagawa J, Zhang Y, Wong ML, Sievers R, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol (1985). 2007 Jun; 102(6):2104-11. PMID: 17347379; PMCID: PMC2675697.
    38. Lee RJ, Fang Q, Davol PA, Gu Y, Sievers R, Grabert RC, Gall JM, Tsang E, Yee MS, Fok H, Huang NF, Padbury JF, Larrick JW, Lum LG. Antibody targeting of stem cells to infarcted myocardium. Stem Cells. 2007 Mar; 25(3):712-7. PMID: 17138964.
      View in: PubMed
    39. Zhang Y, Takagawa J, Sievers R, Khan MF, Viswanathan MN, Springer ML, Foster E, Yeghiazarians Y. Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1187-92. PMID: 17028161.
      View in: PubMed
    40. Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W. Left ventricular pressure-volume relationship in conscious mice. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H369-77. PMID: 16905597.
      View in: PubMed
    41. Huang NF, Sievers R, Park JS, Fang Q, Li S, Lee RJ. A rodent model of myocardial infarction for testing the efficacy of cells and polymers for myocardial reconstruction. Nat Protoc. 2006; 1(3):1596-609. PMID: 17406452.
      View in: PubMed
    42. Huang NF, Yu J, Sievers R, Li S, Lee RJ. Injectable biopolymers enhance angiogenesis after myocardial infarction. Tissue Eng. 2005 Nov-Dec; 11(11-12):1860-6. PMID: 16411832.
      View in: PubMed
    43. Christman KL, Fang Q, Kim AJ, Sievers R, Fok HH, Candia AF, Colley KJ, Herradon G, Ezquerra L, Deuel TF, Lee RJ. Pleiotrophin induces formation of functional neovasculature in vivo. Biochem Biophys Res Commun. 2005 Jul 15; 332(4):1146-52. PMID: 15949466.
      View in: PubMed
    44. Springer ML, Sievers R, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1307-14. PMID: 15908468.
      View in: PubMed
    45. Christman KL, Fang Q, Yee MS, Johnson KR, Sievers R, Lee RJ. Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymer. Biomaterials. 2005 Apr; 26(10):1139-44. PMID: 15451633.
      View in: PubMed
    46. Christman KL, Vardanian AJ, Fang Q, Sievers R, Fok HH, Lee RJ. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. J Am Coll Cardiol. 2004 Aug 04; 44(3):654-60. PMID: 15358036.
      View in: PubMed
    47. Christman KL, Fok HH, Sievers R, Fang Q, Lee RJ. Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction. Tissue Eng. 2004 Mar-Apr; 10(3-4):403-9. PMID: 15165457.
      View in: PubMed
    48. Lum LG, Fok H, Sievers R, Abedi M, Quesenberry PJ, Lee RJ. Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardium. Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):82-7. PMID: 14757418.
      View in: PubMed
    49. Ishizaka S, Sievers R, Zhu BQ, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W. New technique for measurement of left ventricular pressure in conscious mice. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H1208-15. PMID: 14563661.
      View in: PubMed
    50. Zhu BQ, Heeschen C, Sievers R, Karliner JS, Parmley WW, Glantz SA, Cooke JP. Second hand smoke stimulates tumor angiogenesis and growth. Cancer Cell. 2003 Sep; 4(3):191-6. PMID: 14522253.
      View in: PubMed
    51. Wu MC, Gao DW, Sievers R, Lee RJ, Hasegawa BH, Dae MW. Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice. J Am Coll Cardiol. 2003 Aug 06; 42(3):576-82. PMID: 12906991.
      View in: PubMed
    52. Zhu BQ, Sievers R, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW. Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. J Renin Angiotensin Aldosterone Syst. 2003 Mar; 4(1):31-7. PMID: 12692751.
      View in: PubMed
    53. Altman PA, Sievers R, Lee R. Exploring heart lymphatics in local drug delivery. Lymphat Res Biol. 2003; 1(1):47-53; discussion 54. PMID: 15624321.
      View in: PubMed
    54. Zhu BQ, Sievers R, Browne AE, Hillman RT, Chair K, Lee RJ, Chatterjee K, Glantz SA, Parmley WW. The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke. J Renin Angiotensin Aldosterone Syst. 2002 Mar; 3(1):54-60. PMID: 11984749.
      View in: PubMed
    55. Hutchison SJ, Sievers R, Zhu BQ, Sun YP, Stewart DJ, Parmley WW, Chatterjee K. Secondhand tobacco smoke impairs rabbit pulmonary artery endothelium-dependent relaxation. Chest. 2001 Dec; 120(6):2004-12. PMID: 11742935.
      View in: PubMed
    56. Sun YP, Zhu BQ, Browne AE, Sievers R, Bekker JM, Chatterjee K, Parmley WW, Glantz SA. Nicotine does not influence arterial lipid deposits in rabbits exposed to second-hand smoke. Circulation. 2001 Aug 14; 104(7):810-4. PMID: 11502707.
      View in: PubMed
    57. Zhu B, Sun Y, Sievers R, Browne AE, Lee RJ, Chatterjee K, Parmley WW. Effects of different durations of pretreatment with losartan on myocardial infarct size, endothelial function, and vascular endothelial growth factor. J Renin Angiotensin Aldosterone Syst. 2001 Jun; 2(2):129-33. PMID: 11881112.
      View in: PubMed
    58. Engler MB, Engler MM, Browne A, Sun YP, Sievers R. Mechanisms of vasorelaxation induced by eicosapentaenoic acid (20:5n-3) in WKY rat aorta. Br J Pharmacol. 2000 Dec; 131(8):1793-9. PMID: 11139460; PMCID: PMC1572512.
    59. Zhu B, Sun Y, Sievers R, Browne AE, Pulukurthy S, Sudhir K, Lee RJ, Chou TM, Chatterjee K, Parmley WW. Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion. J Am Coll Cardiol. 2000 Mar 01; 35(3):787-95. PMID: 10716484.
      View in: PubMed
    60. Sievers R, Tang AT, Haw MP. Complete surgical resection of intrapericardial teratoma in a neonate with compression of the central airways. Cardiol Young. 2000 Jan; 10(1):64-6. PMID: 10695546.
      View in: PubMed
    61. Hutchison SJ, Sudhir K, Sievers R, Zhu BQ, Sun YP, Chou TM, Chatterjee K, Deedwania PC, Cooke JP, Glantz SA, Parmley WW. Effects of L-arginine on atherogenesis and endothelial dysfunction due to secondhand smoke. Hypertension. 1999 Jul; 34(1):44-50. PMID: 10406822.
      View in: PubMed
    62. Lee RJ, Sievers R, Gallinghouse GJ, Ursell PC. Development of a model of complete heart block in rats. J Appl Physiol (1985). 1998 Aug; 85(2):758-63. PMID: 9688757.
      View in: PubMed
    63. Sun YP, Zhu BQ, Sievers R, Norkus EP, Parmley WW, Deedwania PC. Effects of antioxidant vitamins C and E on atherosclerosis in lipid-fed rabbits. Cardiology. 1998 Mar; 89(3):189-94. PMID: 9570433.
      View in: PubMed
    64. Zhu BQ, Sun YP, Sudhir K, Sievers R, Browne AE, Gao L, Hutchison SJ, Chou TM, Deedwania PC, Chatterjee K, Glantz SA, Parmley WW. Effects of second-hand smoke and gender on infarct size of young rats exposed in utero and in the neonatal to adolescent period. J Am Coll Cardiol. 1997 Dec; 30(7):1878-85. PMID: 9385922.
      View in: PubMed
    65. Piot CA, Padmanaban D, Ursell PC, Sievers R, Wolfe CL. Ischemic preconditioning decreases apoptosis in rat hearts in vivo. Circulation. 1997 Sep 02; 96(5):1598-604. PMID: 9315553.
      View in: PubMed
    66. Hutchison SJ, Reitz MS, Sudhir K, Sievers R, Zhu BQ, Sun YP, Chou TM, Deedwania PC, Chatterjee K, Glantz SA, Parmley WW. Chronic dietary L-arginine prevents endothelial dysfunction secondary to environmental tobacco smoke in normocholesterolemic rabbits. Hypertension. 1997 May; 29(5):1186-91. PMID: 9149685.
      View in: PubMed
    67. Hutchison SJ, Sudhir K, Chou TM, Sievers R, Zhu BQ, Sun YP, Deedwania PC, Glantz SA, Parmley WW, Chatterjee K. Testosterone worsens endothelial dysfunction associated with hypercholesterolemia and environmental tobacco smoke exposure in male rabbit aorta. J Am Coll Cardiol. 1997 Mar 15; 29(4):800-7. PMID: 9091527.
      View in: PubMed
    68. Hutter JJ, Mestril R, Tam EK, Sievers R, Dillmann WH, Wolfe CL. Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo. Circulation. 1996 Sep 15; 94(6):1408-11. PMID: 8823000.
      View in: PubMed
    69. Zhu B, Sun Y, Sievers R, Shuman JL, Glantz SA, Chatterjee K, Parmley WW, Wolfe CL. L-arginine decreases infarct size in rats exposed to environmental tobacco smoke. Am Heart J. 1996 Jul; 132(1 Pt 1):91-100. PMID: 8701882.
      View in: PubMed
    70. Barbosa V, Sievers R, Zaugg CE, Wolfe CL. Preconditioning ischemia time determines the degree of glycogen depletion and infarct size reduction in rat hearts. Am Heart J. 1996 Feb; 131(2):224-30. PMID: 8579012.
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    71. Auyeung Y, Sievers R, Weng D, Barbosa V, Wolfe CL. Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats. Circulation. 1995 Dec 01; 92(11):3318-22. PMID: 7586320.
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    72. Sun YP, Zhu BQ, Sievers R, Glantz SA, Parmley WW. Metoprolol does not attenuate atherosclerosis in lipid-fed rabbits exposed to environmental tobacco smoke. Circulation. 1994 May; 89(5):2260-5. PMID: 8181151.
      View in: PubMed
    73. Zhu BQ, Sievers R, Sun YP, Morse-Fisher N, Parmley WW, Wolfe CL. Is the reduction of myocardial infarct size by dietary fish oil the result of altered platelet function? Am Heart J. 1994 Apr; 127(4 Pt 1):744-55. PMID: 8154411.
      View in: PubMed
    74. Zhu BQ, Sun YP, Sievers R, Glantz SA, Parmley WW, Wolfe CL. Exposure to environmental tobacco smoke increases myocardial infarct size in rats. Circulation. 1994 Mar; 89(3):1282-90. PMID: 8124817.
      View in: PubMed
    75. Hutter MM, Sievers R, Barbosa V, Wolfe CL. Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection. Circulation. 1994 Jan; 89(1):355-60. PMID: 8281669.
      View in: PubMed
    76. Zhu BQ, Sun YP, Sievers R, Isenberg WM, Moorehead TJ, Parmley WW. Effects of etidronate and lovastatin on the regression of atherosclerosis in cholesterol-fed rabbits. Cardiology. 1994; 85(6):370-7. PMID: 7697672.
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    77. Levitt MA, Sievers R, Wolfe CL. Reduction of infarct size during myocardial ischemia and reperfusion by lazaroid U-74500A, a nonglucocorticoid 21-aminosteroid. J Cardiovasc Pharmacol. 1994 Jan; 23(1):136-40. PMID: 7511726.
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    78. Wolfe CL, O'Connell JW, Sievers R, Cobb C, Dae MW, Botvinick E. Assessment of perfused left ventricular mass in normal, ischemic, and reperfused myocardium by means of single-photon emission computed tomography of technetium-99m isonitrile. Am Heart J. 1993 Dec; 126(6):1275-86. PMID: 8249782.
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    79. Wolfe CL, Sievers R, Visseren FL, Donnelly TJ. Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment. Circulation. 1993 Mar; 87(3):881-92. PMID: 8443909.
      View in: PubMed
    80. Sun YP, Zhu BQ, Sievers R, Isenberg WM, Parmley WW. Aspirin inhibits platelet activity but does not attenuate experimental atherosclerosis. Am Heart J. 1993 Jan; 125(1):79-86. PMID: 8417546.
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    81. Zhu BQ, Sun YP, Sievers R, Isenberg WM, Glantz SA, Parmley WW. Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits. J Am Coll Cardiol. 1993 Jan; 21(1):225-32. PMID: 8417066.
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    82. Gould R, Brasch RC, Sievers R, Baxter A, Aicher K. Comparison of vascular opacification after bolus injection of iodixanol-320 iohexol-350. Invest Radiol. 1992 Dec; 27(12):1031-4. PMID: 1473920.
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    83. Vexler VS, Berthezène Y, Wolfe CL, Sievers R, Dupon JW, Aicher K, Moseley ME, Brasch RC. Magnetic resonance imaging demonstration of pharmacologic-induced myocardial vasodilatation using a macromolecular gadolinium contrast agent. Invest Radiol. 1992 Nov; 27(11):935-41. PMID: 1464513.
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    84. Zhu BQ, Sievers R, Sun YP, Isenberg WM, Parmley WW. Effect of lovastatin on suppression and regression of atherosclerosis in lipid-fed rabbits. J Cardiovasc Pharmacol. 1992 Feb; 19(2):246-55. PMID: 1376794.
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    85. Donnelly TJ, Sievers R, Vissern FL, Welch WJ, Wolfe CL. Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion? Circulation. 1992 Feb; 85(2):769-78. PMID: 1735169.
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