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Richard Guy, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentBioengineering
Address401 Parnassus Ave, LangPorter
San Francisco CA 94143
Phone441-225-3849 ext. 01
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    Collapse Biography 
    Collapse Education and Training
    Oxford University, Oxford, U.K.M.A.08/1977Chemistry
    University of London, London, U.K.Ph.D.08/1980Pharmaceutical Chemistry
    Oxford University, Oxford, U.K.D.Sc.01/2016Medical Sciences

    Collapse Overview 
    Collapse Overview
    Richard Guy received an M.A. in Chemistry from Oxford University, and his Ph.D. in Pharmaceutical Chemistry from the University of London. He has held academic posts at the University of California, San Francisco (where he remains an Adjunct Professor) and the University of Geneva. In 2004, he joined the University of Bath as Professor of Pharmaceutical Sciences, and he currently serves as the Chair of the Research Committee of the Department of Pharmacy & Pharmacology. Dr. Guy is an elected fellow of the Academy of Pharmaceutical Scientists, Great Britain, the Royal Society of Chemistry, the Controlled Release Society, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science.

    Dr. Guy's research focuses on skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing, and the prediction and assessment of skin penetration and topical bioavailability. Dr. Guy has published 300+ peer-reviewed articles and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 12 patents. Specific ongoing projects include: measurement of the skin's biomechanical properties at the nanoscale using atomic force microscopy; the detection and quantification of skin barrier disruption by surfactants found in commonly used cosmetic, personal care and pharmaceutical products; the potential of polymeric film-forming systems as sustained release platforms for topical drugs; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin using coherent Raman scattering and confocal microscopy; identification of skin-penetrating constituents of traditional, topical Thai medicines and their re-formulation; development of an integrated iontophoretic delivery system for buprenorphine and naltrexone to treat polydrug abuse; examination of a graphene-based biosensor for noninvasive, transdermal glucose monitoring; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which come into contact with skin.


    Collapse Research 
    Collapse Research Activities and Funding
    Bioequivalence of topical drug products: in vitro - in vivo correlations
    FDA U01FD004947Sep 1, 2013 - Aug 31, 2018
    Role: Co-Principal Investigator
    Skin Bioengineering: Noninvasive Transdermal Monitoring
    NIH/NIBIB R01EB001420Aug 15, 2003 - Jul 31, 2008
    Role: Principal Investigator
    NEONATAL SKIN--BARRIER FUNCTION AND DRUG DELIVERY
    NIH/NIDA R01DA009292Mar 15, 1995 - Mar 31, 1999
    Role: Principal Investigator
    LASER SCANNING CONFOCAL MICROSCOPE
    NIH/NCRR S10RR007131May 19, 1992 - May 18, 1993
    Role: Principal Investigator
    MECHANISMS OF IONTOPHORETIC DRUG DELIVERY ACROSS SKIN
    NIH/NICHD R01HD027839Aug 1, 1990 - Jul 31, 1994
    Role: Principal Investigator
    GORDON CONFERENCE ON BARRIER FUNCTION OF MAMMALIAN SKIN
    NIH/NIAMS R13AR040145Aug 16, 1989 - Aug 15, 1990
    Role: Principal Investigator
    MECHANISM AND ENHANCEMENT OF TRANSDERMAL ABSORPTION
    NIH/NICHD R01HD023010Apr 1, 1987 - Jun 30, 1997
    Role: Principal Investigator
    PERCUTANEOUS ABSORPTION: A KINETIC APPROACH
    NIH/NIGMS R01GM033395Jan 1, 1985 - Jun 30, 1988
    Role: Principal Investigator
    CUTANEOUS EXPOSURE: PREDICTIVE PATHWAYS
    CDC/NIOSH K01OH000017Sep 28, 1984 - Dec 31, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Oakland K, Jairath V, Uberoi R, Guy R, Ayaru L, Mortensen N, Murphy MF, Collins GS. Derivation and validation of a novel risk score for safe discharge after acute lower gastrointestinal bleeding: a modelling study. Lancet Gastroenterol Hepatol. 2017 Sep; 2(9):635-643. PMID: 28651935.
      View in: PubMed
    2. Cordery SF, Pensado A, Chiu WS, Shehab MZ, Bunge AL, Delgado-Charro MB, Guy R. Topical bioavailability of diclofenac from locally-acting, dermatological formulations. Int J Pharm. 2017 Aug 30; 529(1-2):55-64. PMID: 28636892.
      View in: PubMed
    3. Ghazanfar MA, Guy R. Tablespoons and corkscrew: a culinary solution for retrieval of a rectal foreign body. ANZ J Surg. 2017 Jun; 87(6):523. PMID: 28585759.
      View in: PubMed
    4. Danielewski JA, Phillips S, Kong FYS, Smith KS, Hocking JS, Guy R, Fairley CK, Garland SM, Tabrizi SN. A snapshot of Chlamydia trachomatis genetic diversity using multilocus sequence type analysis in an Australian metropolitan setting. Eur J Clin Microbiol Infect Dis. 2017 Jul; 36(7):1297-1303. PMID: 28220321.
      View in: PubMed
    5. Oakland K, Guy R, Uberoi R, Hogg R, Mortensen N, Murphy MF, Jairath V. Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit. Gut. 2017 Feb 01. PMID: 28148540.
      View in: PubMed
    6. Leal LB, Cordery SF, Delgado-Charro MB, Bunge AL, Guy R. Bioequivalence Methodologies for Topical Drug Products: In Vitro and Ex Vivo Studies with a Corticosteroid and an Anti-Fungal Drug. Pharm Res. 2017 Apr; 34(4):730-737. PMID: 28097506.
      View in: PubMed
    7. Sánchez MI, McCullagh J, Guy R, Compton RG. Reverse Iontophoretic Extraction of Metabolites from Living Plants and their Identification by Ion-chromatography Coupled to High Resolution Mass Spectrometry. Phytochem Anal. 2017 May; 28(3):195-201. PMID: 28029194.
      View in: PubMed
    8. Abernethy J, Guy R, Sheridan EA, Hopkins S, Kiernan M, Wilcox MH, Johnson AP, Hope R. Epidemiology of Escherichia coli bacteraemia in England: results of an enhanced sentinel surveillance programme. J Hosp Infect. 2017 Apr; 95(4):365-375. PMID: 28190700.
      View in: PubMed
    9. Callander D, Stoové M, Carr A, Hoy JF, Petoumenos K, Hellard M, Elliot J, Templeton DJ, Liaw S, Wilson DP, Grulich A, Cooper DA, Pedrana A, Donovan B, McMahon J, Prestage G, Holt M, Fairley CK, McKellar-Stewart N, Ruth S, Asselin J, Keen P, Cooper C, Allan B, Kaldor JM, Guy R. A longitudinal cohort study of HIV 'treatment as prevention' in gay, bisexual and other men who have sex with men: the Treatment with Antiretrovirals and their Impact on Positive And Negative men (TAIPAN) study protocol. BMC Infect Dis. 2016 Dec 12; 16(1):752. PMID: 27955627.
      View in: PubMed
    10. Celebi D, Guy R, Edler KJ, Scott JL. Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations. Int J Pharm. 2016 Nov 30; 514(1):238-243. PMID: 27863667.
      View in: PubMed
    11. Ridd MJ, Garfield K, Gaunt DM, Hollinghurst S, Redmond NM, Powell K, Wilson V, Guy R, Ball N, Shaw L, Purdy S, Metcalfe C. Choice of Moisturiser for Eczema Treatment (COMET): feasibility study of a randomised controlled parallel group trial in children recruited from primary care. BMJ Open. 2016 Nov 16; 6(11):e012021. PMID: 27852708.
      View in: PubMed
    12. Keen P, Conway DP, Cunningham P, McNulty A, Couldwell DL, Davies SC, Smith DE, Gray J, Holt M, O'Connor CC, Read P, Callander D, Prestage G, Guy R. Multi-centre field evaluation of the performance of the Trinity Biotech Uni-Gold HIV 1/2 rapid test as a first-line screening assay for gay and bisexual men compared with 4th generation laboratory immunoassays. J Clin Virol. 2017 Jan; 86:46-51. PMID: 27914286.
      View in: PubMed
    13. Singhal S, Giner-Segura F, Hompes R, Guy R, Wang LM. Letter to the Editor With Regard to the Article Entitled: "A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritoneii and Associated Appendiceal Neoplasia". Am J Surg Pathol. 2016 Nov; 40(11):1577-1578. PMID: 27631513.
      View in: PubMed
    14. Rzhevskiy AS, Guy R, Anissimov YG. Modelling drug flux through microporated skin. J Control Release. 2016 Nov 10; 241:194-199. PMID: 27686580.
      View in: PubMed
    15. Celebi D, Guy R, Edler KJ, Scott JL. Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations. Int J Pharm. 2016 Sep 20. PMID: 27863988.
      View in: PubMed
    16. Oakland K, Guy R, Uberoi R, Seeney F, Collins G, Grant-Casey J, Mortensen N, Murphy M, Jairath V. Study protocol: first nationwide comparative audit of acute lower gastrointestinal bleeding in the UK. BMJ Open. 2016 Aug 04; 6(8):e011752. PMID: 27491671; PMCID: PMC4985848.
    17. Toliman P, Badman SG, Gabuzzi J, Silim S, Forereme L, Kumbia A, Kombuk B, Kombati Z, Allan J, Munnull G, Ryan C, Vallely LM, Kelly-Hanku A, Wand H, Mola GD, Guy R, Siba P, Kaldor JM, Tabrizi SN, Vallely AJ. Field Evaluation of Xpert HPV Point-of-Care Test for Detection of Human Papillomavirus Infection by Use of Self-Collected Vaginal and Clinician-Collected Cervical Specimens. J Clin Microbiol. 2016 Jul; 54(7):1734-7. PMID: 27076663; PMCID: PMC4922075 [Available on 01/01/17].
    18. Guy R. Diagnostic devices: Managing diabetes through the skin. Nat Nanotechnol. 2016 Jun; 11(6):493-4. PMID: 26999480.
      View in: PubMed
    19. Smith KS, Kaldor JM, Hocking JS, Jamil MS, McNulty AM, Read P, Bradshaw CS, Chen MY, Fairley CK, Wand H, Worthington K, Blake S, Knight V, Rawlinson W, Saville M, Tabrizi SN, Garland SM, Donovan B, Guy R. The acceptability and cost of a home-based chlamydia retesting strategy: findings from the REACT randomised controlled trial. BMC Public Health. 2016 Jan 28; 16:83. PMID: 26822715; PMCID: PMC4730759.
    20. Williams FM, Rothe H, Barrett G, Chiodini A, Whyte J, Cronin MT, Monteiro-Riviere NA, Plautz J, Roper C, Westerhout J, Yang C, Guy R. Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern). Regul Toxicol Pharmacol. 2016 Apr; 76:174-86. PMID: 26825378.
      View in: PubMed
    21. Yeung TM, Volpi D, Tullis ID, Nicholson GA, Buchs N, Cunningham C, Guy R, Lindsey I, George B, Jones O, Wang LM, Hompes R, Vojnovic B, Hamdy F, Mortensen NJ. Identifying Ureters In Situ Under Fluorescence During Laparoscopic and Open Colorectal Surgery. Ann Surg. 2016 Jan; 263(1):e1-2. PMID: 26672509.
      View in: PubMed
    22. Buchs NC, Nicholson GA, Yeung T, Mortensen NJ, Cunningham C, Jones OM, Guy R, Hompes R. Transanal rectal resection: an initial experience of 20 cases. Colorectal Dis. 2016 Jan; 18(1):45-50. PMID: 26639062.
      View in: PubMed
    23. Badman SG, Causer LM, Guy R, Tabrizi SN, Francis F, Donovan B, Whiley D. A preliminary evaluation of a new GeneXpert (Gx) molecular point-of-care test for the detection of Trichomonas vaginalis. Sex Transm Infect. 2016 Aug; 92(5):350-2. PMID: 26702132.
      View in: PubMed
    24. Frederiksen K, Guy R, Petersson K. The potential of polymeric film-forming systems as sustained delivery platforms for topical drugs. Expert Opin Drug Deliv. 2016; 13(3):349-60. PMID: 26609868.
      View in: PubMed
    25. Buchs NC, Kraus R, Mortensen NJ, Cunningham C, George B, Jones O, Guy R, Ashraf S, Lindsey I, Hompes R. Endoscopically assisted extralevator abdominoperineal excision. Colorectal Dis. 2015 Dec; 17(12):O277-80. PMID: 26454256.
      View in: PubMed
    26. González-Sánchez MI, Lee PT, Guy R, Compton RG. In situ detection of salicylate in Ocimum basilicum plant leaves via reverse iontophoresis. Chem Commun (Camb). 2015 Nov 28; 51(92):16534-6. PMID: 26419728.
      View in: PubMed
    27. Chiu WS, Belsey NA, Garrett NL, Moger J, Price GJ, Delgado-Charro MB, Guy R. Drug delivery into microneedle-porated nails from nanoparticle reservoirs. J Control Release. 2015 Dec 28; 220(Pt A):98-106. PMID: 26478016.
      View in: PubMed
    28. Garvie-Cook H, Stone JM, Yu F, Guy R, Gordeev SN. Femtosecond pulsed laser ablation to enhance drug delivery across the skin. J Biophotonics. 2016 Jan; 9(1-2):144-54. PMID: 26449289.
      View in: PubMed
    29. Bracey E, Knol J, Buchs N, Jones O, Cunningham C, Guy R, Mortensen N, Hompes R. Technique for a stapled anastomosis following transanal total mesorectal excision for rectal cancer. Colorectal Dis. 2015 Oct; 17(10):O208-12. PMID: 26218610.
      View in: PubMed
    30. Mason E, Wray L, Foster R, Jamil MS, Guy R, McNulty A, Donovan B. Reactive arthritis at the Sydney Sexual Health Centre 1992-2012: declining despite increasing chlamydia diagnoses. Int J STD AIDS. 2016 Sep; 27(10):882-9. PMID: 26378192.
      View in: PubMed
    31. Wang LM, Guy R, Fryer E, Kartsonaki C, Gill P, Hughes C, Szuts A, Perera R, Chetty R, Mortensen N. The Ueno method for substaging pT1 colorectal adenocarcinoma by depth and width measurement: an interobserver study. Colorectal Dis. 2015 Aug; 17(8):674-81. PMID: 25620664.
      View in: PubMed
    32. Gelfuso GM, Barros MA, Delgado-Charro MB, Guy R, Lopez RF. Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting? Colloids Surf B Biointerfaces. 2015 Oct 01; 134:408-12. PMID: 26222406.
      View in: PubMed
    33. Ridd MJ, Redmond NM, Hollinghurst S, Ball N, Shaw L, Guy R, Wilson V, Metcalfe C, Purdy S. Choice of Moisturiser for Eczema Treatment (COMET): study protocol for a randomized controlled trial. Trials. 2015 Jul 15; 16:304. PMID: 26170126; PMCID: PMC4501045.
    34. Garvie-Cook H, Frederiksen K, Petersson K, Guy R, Gordeev SN. Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems. J Control Release. 2015 Aug 28; 212:103-12. PMID: 26087467.
      View in: PubMed
    35. Chiu WS, Belsey NA, Garrett NL, Moger J, Delgado-Charro MB, Guy R. Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7725-30. PMID: 26056283; PMCID: PMC4485099.
    36. Gainza G, Chu WS, Guy R, Pedraz JL, Hernandez RM, Delgado-Charro B, Igartua M. Development and in vitro evaluation of lipid nanoparticle-based dressings for topical treatment of chronic wounds. Int J Pharm. 2015 Jul 25; 490(1-2):404-11. PMID: 26043822.
      View in: PubMed
    37. Misteli H, Koh CE, Wang LM, Mortensen NJ, George B, Guy R. Myenteric plexitis at the proximal resection margin is a predictive marker for surgical recurrence of ileocaecal Crohn's disease. Colorectal Dis. 2015 Apr; 17(4):304-10. PMID: 25581299.
      View in: PubMed
    38. Clarke JF, Cordery SF, Morgan NA, Knowles PK, Guy R. In Vitro Method to Quantify Dermal Absorption of Pesticide Residues. Chem Res Toxicol. 2015 Feb 16; 28(2):166-8. PMID: 25647690.
      View in: PubMed
    39. Mishra A, Gosselink MP, Mortensen NJ, George BD, Cunningham C, Lindsey I, Guy R, Jones OM, Hompes R. Problem solving after marginal artery injury during splenic flexure mobilization - a video vignette. Colorectal Dis. 2015 Feb; 17(2):174-5. PMID: 25384924.
      View in: PubMed
    40. Garvie-Cook H, Frederiksen K, Petersson K, Guy R, Gordeev S. Characterization of topical film-forming systems using atomic force microscopy and Raman microspectroscopy. Mol Pharm. 2015 Mar 02; 12(3):751-7. PMID: 25586343.
      View in: PubMed
    41. Conway DP, Guy R, McNulty A, Couldwell DL, Davies SC, Smith DE, Keen P, Cunningham P, Holt M. Effect of testing experience and profession on provider acceptability of rapid HIV testing after implementation in public sexual health clinics in Sydney. HIV Med. 2015 May; 16(5):280-7. PMID: 25604470.
      View in: PubMed
    42. Abernethy JK, Johnson AP, Guy R, Hinton N, Sheridan EA, Hope RJ. Thirty day all-cause mortality in patients with Escherichia coli bacteraemia in England. Clin Microbiol Infect. 2015 Mar; 21(3):251.e1-8. PMID: 25698659.
      View in: PubMed
    43. Frederiksen K, Guy R, Petersson K. Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin. Eur J Pharm Biopharm. 2015 Apr; 91:9-15. PMID: 25595740.
      View in: PubMed
    44. Gosselink MP, Mishra A, Mortensen NJ, George B, Cunningham C, Lindsey I, Guy R, Jones OM, Hompes R. Laparoscopic modified Sugarbaker technique for the repair of an urostomal hernia - a video vignette. Colorectal Dis. 2015 Jan; 17(1):90-1. PMID: 25294022.
      View in: PubMed
    45. Thitilertdecha P, Rowan MG, Guy R. Topical formulation and dermal delivery of active phenolic compounds in the Thai medicinal plant--Clerodendrum petasites S. Moore. Int J Pharm. 2015 Jan 15; 478(1):39-45. PMID: 25445977.
      View in: PubMed
    46. Boyd MA, Donovan B, Prestage G, Chen M, Petoumenos K, Gray R, Guy R, Rogers GB, Bourne C, Klausner JD. Is it time to rethink syphilis control? Clin Infect Dis. 2015 Jan 15; 60(2):325-6. PMID: 25323705.
      View in: PubMed
    47. Djabri A, Van't Hoff W, Brock P, Wong IC, Guy R, Delgado-Charro MB. Iontophoretic transdermal sampling of iohexol as a non-invasive tool to assess glomerular filtration rate. Pharm Res. 2015 Feb; 32(2):590-603. PMID: 25190007.
      View in: PubMed
    48. Yang Q, Guy R. Characterisation of skin barrier function using bioengineering and biophysical techniques. Pharm Res. 2015 Feb; 32(2):445-57. PMID: 25092069.
      View in: PubMed
    49. Yang M, Prestage G, Maycock B, Brown G, de Wit J, McKechnie M, Guy R, Keen P, Fairley CK, Zablotska IB. The acceptability of different HIV testing approaches: cross-sectional study among GMSM in Australia. Sex Transm Infect. 2014 Dec; 90(8):592-5. PMID: 25015651.
      View in: PubMed
    50. Hompes R, Guy R, Jones O, Lindsey I, Mortensen N, Cunningham C. Transanal total mesorectal excision with a side-to-end stapled anastomosis - a video vignette. Colorectal Dis. 2014 Jul; 16(7):567. PMID: 24801986.
      View in: PubMed
    51. Wiedersberg S, Guy R. Transdermal drug delivery: 30+ years of war and still fighting! J Control Release. 2014 Sep 28; 190:150-6. PMID: 24852092.
      View in: PubMed
    52. Guy R, Kuma H, Nakanishi M. Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation. Eur J Dermatol. 2014 May-Jun; 24(3):365-71. PMID: 24721981.
      View in: PubMed
    53. Thitilertdecha P, Guy R, Rowan MG. Characterisation of polyphenolic compounds in Clerodendrum petasites S. Moore and their potential for topical delivery through the skin. J Ethnopharmacol. 2014 Jun 11; 154(2):400-7. PMID: 24747028.
      View in: PubMed
    54. Kong FY, Tabrizi SN, Law M, Vodstrcil LA, Chen M, Fairley CK, Guy R, Bradshaw C, Hocking JS. Azithromycin versus doxycycline for the treatment of genital chlamydia infection: a meta-analysis of randomized controlled trials. Clin Infect Dis. 2014 Jul 15; 59(2):193-205. PMID: 24729507.
      View in: PubMed
    55. Guy R, Williams C, Irvine N, Reynolds A, Coelho J, Saliba V, Thomas D, Doherty L, Chalker V, von Wissmann B, Chand M, Efstratiou A, Ramsay M, Lamagni T. Increase in scarlet fever notifications in the United Kingdom, 2013/2014. Euro Surveill. 2014 Mar 27; 19(12):20749. PMID: 24698137.
      View in: PubMed
    56. Ris F, Hompes R, Cunningham C, Lindsey I, Guy R, Jones O, George B, Cahill RA, Mortensen NJ. Near-infrared (NIR) perfusion angiography in minimally invasive colorectal surgery. Surg Endosc. 2014 Jul; 28(7):2221-6. PMID: 24566744; PMCID: PMC4065377.
    57. Guy R. Interview with Richard H Guy by Hannah Coaker. Ther Deliv. 2014 Feb; 5(2):123-8. PMID: 24483191.
      View in: PubMed
    58. Delgado-Charro MB, Guy R. Effective use of transdermal drug delivery in children. Adv Drug Deliv Rev. 2014 Jun; 73:63-82. PMID: 24333231.
      View in: PubMed
    59. Belsey NA, Garrett NL, Contreras-Rojas LR, Pickup-Gerlaugh AJ, Price GJ, Moger J, Guy R. Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies. J Control Release. 2014 Jan 28; 174:37-42. PMID: 24231405.
      View in: PubMed
    60. Güngör S, Delgado-Charro MB, Masini-Etévé V, Potts RO, Guy R. Transdermal flux predictions for selected selective oestrogen receptor modulators (SERMs): comparison with experimental results. J Control Release. 2013 Dec 28; 172(3):601-6. PMID: 24076520.
      View in: PubMed
    61. Guy R. Skin--'that unfakeable young surface'. Skin Pharmacol Physiol. 2013; 26(4-6):181-9. PMID: 23921104.
      View in: PubMed
    62. Ridd M, Guy R, Ball N, Roberts A, Williams H. Products in "Bounty bags" potentially harm newborn skin. BMJ. 2013 Jun 18; 346:f3895. PMID: 23778276.
      View in: PubMed
    63. Benzeval I, Bowen CR, Guy R, Delgado-Charro MB. Effects of iontophoresis, hydration, and permeation enhancers on human nail plate: infrared and impedance spectroscopy assessment. Pharm Res. 2013 Jun; 30(6):1652-62. PMID: 23462934.
      View in: PubMed
    64. Gelfuso GM, Gratieri T, Delgado-Charro MB, Guy R, Vianna Lopez RF. Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia. J Pharm Sci. 2013 May; 102(5):1488-94. PMID: 23450524.
      View in: PubMed
    65. Cordery SF, Taverner A, Ridzwan IE, Guy R, Delgado-Charro MB, Husbands SM, Bailey CP. A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addict Biol. 2014 Jul; 19(4):575-86. PMID: 23240906.
      View in: PubMed
    66. Beard JD, Guy R, Gordeev SN. Mechanical tomography of human corneocytes with a nanoneedle. J Invest Dermatol. 2013 Jun; 133(6):1565-71. PMID: 23223139.
      View in: PubMed
    67. Russell LM, Guy R. Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies: proof-of-concept with acyclovir formulations. Pharm Res. 2012 Dec; 29(12):3362-72. PMID: 22810836.
      View in: PubMed
    68. Campbell CS, Contreras-Rojas LR, Delgado-Charro MB, Guy R. Objective assessment of nanoparticle disposition in mammalian skin after topical exposure. J Control Release. 2012 Aug 20; 162(1):201-7. PMID: 22732479.
      View in: PubMed
    69. Mohammed D, Yang Q, Guy R, Matts PJ, Hadgraft J, Lane ME. Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping. Eur J Pharm Biopharm. 2012 Sep; 82(1):171-4. PMID: 22713518.
      View in: PubMed
    70. Russell LM, Guy R. Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies. Pharm Res. 2012 Sep; 29(9):2389-97. PMID: 22562497.
      View in: PubMed
    71. Djabri A, Guy R, Delgado-Charro MB. Transdermal iontophoresis of ranitidine: an opportunity in paediatric drug therapy. Int J Pharm. 2012 Oct 01; 435(1):27-32. PMID: 22429890.
      View in: PubMed
    72. Djabri A, Guy R, Delgado-Charro MB. Passive and iontophoretic transdermal delivery of phenobarbital: Implications in paediatric therapy. Int J Pharm. 2012 Oct 01; 435(1):76-82. PMID: 22387370.
      View in: PubMed
    73. Guy R, Mustikawati DE, Wijaksono DB, Nugraihini N, Priohutomo S, Silitonga N, Kaldor JM. Voluntary counselling and testing sites as a source of sentinel information on HIV prevalence in a concentrated epidemic: a pilot project from Indonesia. Int J STD AIDS. 2011 Sep; 22(9):505-11. PMID: 21890546.
      View in: PubMed
    74. Wilson J, Guy R, Elgohari S, Sheridan E, Davies J, Lamagni T, Pearson A. Trends in sources of meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia: data from the national mandatory surveillance of MRSA bacteraemia in England, 2006-2009. J Hosp Infect. 2011 Nov; 79(3):211-7. PMID: 21764174.
      View in: PubMed
    75. Drummond F, Ryder N, Wand H, Guy R, Read P, McNulty AM, Wray L, Donovan B. Is azithromycin adequate treatment for asymptomatic rectal chlamydia? Int J STD AIDS. 2011 Aug; 22(8):478-80. PMID: 21742812.
      View in: PubMed
    76. Saar BG, Contreras-Rojas LR, Xie XS, Guy R. Imaging drug delivery to skin with stimulated Raman scattering microscopy. Mol Pharm. 2011 Jun 06; 8(3):969-75. PMID: 21548600; PMCID: PMC3109166.
    77. Hompes R, Lindsey I, Jones OM, Guy R, Cunningham C, Mortensen NJ, Cahill RA. Step-wise integration of single-port laparoscopic surgery into routine colorectal surgical practice by use of a surgical glove port. Tech Coloproctol. 2011 Jun; 15(2):165-71. PMID: 21528438.
      View in: PubMed
    78. Belsey NA, Cordery SF, Bunge AL, Guy R. Assessment of dermal exposure to pesticide residues during re-entry. Environ Sci Technol. 2011 May 15; 45(10):4609-15. PMID: 21510672.
      View in: PubMed
    79. Mitragotri S, Anissimov YG, Bunge AL, Frasch HF, Guy R, Hadgraft J, Kasting GB, Lane ME, Roberts MS. Mathematical models of skin permeability: an overview. Int J Pharm. 2011 Oct 10; 418(1):115-29. PMID: 21356301.
      View in: PubMed
    80. Bourne C, Knight V, Guy R, Wand H, Lu H, McNulty A. Short message service reminder intervention doubles sexually transmitted infection/HIV re-testing rates among men who have sex with men. Sex Transm Infect. 2011 Apr; 87(3):229-31. PMID: 21296796.
      View in: PubMed
    81. Zakikhany K, Degail MA, Lamagni T, Waight P, Guy R, Zhao H, Efstratiou A, Pebody R, George R, Ramsay M. Increase in invasive Streptococcus pyogenes and Streptococcus pneumoniae infections in England, December 2010 to January 2011. Euro Surveill. 2011 Feb 03; 16(5). PMID: 21315057.
      View in: PubMed
    82. Guy R, Szoka FC. Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion. Phys Chem Chem Phys. 2011 Mar 28; 13(12):5346-52. PMID: 21286598.
      View in: PubMed
    83. Guy R, George B. Use of topical negative pressure in assisted abdominal closure does not lead to high incidence of enteric fistulae. Colorectal Dis. 2011 Jan; 13(1):108-9. PMID: 20955509.
      View in: PubMed
    84. Tsang M, Guy R. Effect of Aqueous Cream BP on human stratum corneum in vivo. Br J Dermatol. 2010 Nov; 163(5):954-8. PMID: 20649794.
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    85. Sylvestre JP, Bouissou CC, Guy R, Delgado-Charro MB. Extraction and quantification of amino acids in human stratum corneum in vivo. Br J Dermatol. 2010 Sep; 163(3):458-65. PMID: 20394632.
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    86. Hathout RM, Mansour S, Mortada ND, Geneidi AS, Guy R. Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function. Mol Pharm. 2010 Aug 02; 7(4):1266-73. PMID: 20545350.
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    87. Cahill RA, Lindsey I, Jones O, Guy R, Mortensen N, Cunningham C. Single-port laparoscopic total colectomy for medically uncontrolled colitis. Dis Colon Rectum. 2010 Aug; 53(8):1143-7. PMID: 20628277.
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    88. Güngör S, Delgado-Charro MB, Ruiz-Perez B, Schubert W, Isom P, Moslemy P, Patane MA, Guy R. Trans-scleral iontophoretic delivery of low molecular weight therapeutics. J Control Release. 2010 Oct 15; 147(2):225-31. PMID: 20655965.
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    89. Watkinson RM, Guy R, Oliveira G, Hadgraft J, Lane ME. Optimisation of cosolvent concentration for topical drug delivery III--influence of lipophilic vehicles on ibuprofen permeation. Skin Pharmacol Physiol. 2011; 24(1):22-6. PMID: 20616625.
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    90. Guy R. Predicting the rate and extent of fragrance chemical absorption into and through the skin. Chem Res Toxicol. 2010 May 17; 23(5):864-70. PMID: 20392076.
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    91. Guy R, Goller JL, Spelman T, El-Hayek C, Gold J, Lim M, Leslie D, Tee BK, Roth N, Anderson J, Fairley CK, Kaldor J, Hellard M. Does the frequency of HIV and STI testing among men who have sex with men in primary care adhere with Australian guidelines? Sex Transm Infect. 2010 Oct; 86(5):371-6. PMID: 20460263.
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    92. Horyniak D, Guy R, Prybylski D, Hellard M, Kaldor J. The utility of voluntary counselling and testing data as a source of information on HIV prevalence: a systematic review. Int J STD AIDS. 2010 May; 21(5):305-11. PMID: 20498096.
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    93. Hathout RM, Woodman TJ, Mansour S, Mortada ND, Geneidi AS, Guy R. Microemulsion formulations for the transdermal delivery of testosterone. Eur J Pharm Sci. 2010 Jun 14; 40(3):188-96. PMID: 20304048.
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    94. Guy R. Transdermal drug delivery. Handb Exp Pharmacol. 2010; (197):399-410. PMID: 20217537.
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    95. Wu X, Landfester K, Musyanovych A, Guy R. Disposition of charged nanoparticles after their topical application to the skin. Skin Pharmacol Physiol. 2010; 23(3):117-23. PMID: 20051712.
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    96. Bouissou CC, Sylvestre JP, Guy R, Delgado-Charro MB. Reverse iontophoresis of amino acids: identification and separation of stratum corneum and subdermal sources in vitro. Pharm Res. 2009 Dec; 26(12):2630-8. PMID: 19806434.
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    97. Wu X, Griffin P, Price GJ, Guy R. Preparation and in vitro evaluation of topical formulations based on polystyrene-poly-2-hydroxyl methacrylate nanoparticles. Mol Pharm. 2009 Sep-Oct; 6(5):1449-56. PMID: 19630401.
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    98. Wu X, Price GJ, Guy R. Disposition of nanoparticles and an associated lipophilic permeant following topical application to the skin. Mol Pharm. 2009 Sep-Oct; 6(5):1441-8. PMID: 19630400.
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    99. Watkinson RM, Guy R, Hadgraft J, Lane ME. Optimisation of cosolvent concentration for topical drug delivery - II: influence of propylene glycol on ibuprofen permeation. Skin Pharmacol Physiol. 2009; 22(4):225-30. PMID: 19648784.
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    100. Wu X, Biatry B, Cazeneuve C, Guy R. Drug delivery to the skin from sub-micron polymeric particle formulations: influence of particle size and polymer hydrophobicity. Pharm Res. 2009 Aug; 26(8):1995-2001. PMID: 19513818.
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    101. Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, Guy R, Macgowan AL, Tazi-Ahnini R, Ward SJ. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009 Aug; 129(8):1892-908. PMID: 19494826.
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    102. Sieg A, Jeanneret F, Fathi M, Hochstrasser D, Rudaz S, Veuthey JL, Guy R, Delgado-Charro MB. Extraction of amino acids by reverse iontophoresis in vivo. Eur J Pharm Biopharm. 2009 May; 72(1):226-31. PMID: 19347973.
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    103. Russell LM, Guy R. Measurement and prediction of the rate and extent of drug delivery into and through the skin. Expert Opin Drug Deliv. 2009 Apr; 6(4):355-69. PMID: 19382880.
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    104. Mehier-Humbert S, Bettinger T, Yan F, Guy R. Influence of polymer adjuvants on the ultrasound-mediated transfection of cells in culture. Eur J Pharm Biopharm. 2009 Aug; 72(3):567-73. PMID: 19268531.
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    105. Guy R, Goller J, Leslie D, Thorpe R, Grierson J, Batrouney C, Kennedy M, Lewis J, Fairley C, Ginige S, Zablotska I, Hellard M. No increase in HIV or sexually transmissible infection testing following a social marketing campaign among men who have sex with men. J Epidemiol Community Health. 2009 May; 63(5):391-6. PMID: 19179366.
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    106. Wiedersberg S, Leopold CS, Guy R. Effects of various vehicles on skin hydration in vivo. Skin Pharmacol Physiol. 2009; 22(3):128-30. PMID: 19136833.
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    107. Watkinson RM, Herkenne C, Guy R, Hadgraft J, Oliveira G, Lane ME. Influence of ethanol on the solubility, ionization and permeation characteristics of ibuprofen in silicone and human skin. Skin Pharmacol Physiol. 2009; 22(1):15-21. PMID: 19088498.
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    108. Yow HN, Wu X, Routh AF, Guy R. Dye diffusion from microcapsules with different shell thickness into mammalian skin. Eur J Pharm Biopharm. 2009 May; 72(1):62-8. PMID: 19084062.
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    109. Nicoli S, Bunge AL, Delgado-Charro MB, Guy R. Dermatopharmacokinetics: factors influencing drug clearance from the stratum corneum. Pharm Res. 2009 Apr; 26(4):865-71. PMID: 19034629.
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    110. N'Dri-Stempfer B, Navidi WC, Guy R, Bunge AL. Improved bioequivalence assessment of topical dermatological drug products using dermatopharmacokinetics. Pharm Res. 2009 Feb; 26(2):316-28. PMID: 18941872.
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    111. Wiedersberg S, Leopold CS, Guy R. Dermatopharmacokinetics of betamethasone 17-valerate: influence of formulation viscosity and skin surface cleaning procedure. Eur J Pharm Biopharm. 2009 Feb; 71(2):362-6. PMID: 18940255.
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    112. Grégoire S, Ribaud C, Benech F, Meunier JR, Garrigues-Mazert A, Guy R. Prediction of chemical absorption into and through the skin from cosmetic and dermatological formulations. Br J Dermatol. 2009 Jan; 160(1):80-91. PMID: 18811683.
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    113. Wiedersberg S, Naik A, Leopold CS, Guy R. Pharmacodynamics and dermatopharmacokinetics of betamethasone 17-valerate: assessment of topical bioavailability. Br J Dermatol. 2009 Mar; 160(3):676-86. PMID: 18782322.
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    114. Sylvestre JP, Guy R, Delgado-Charro MB. In vitro optimization of dexamethasone phosphate delivery by iontophoresis. Phys Ther. 2008 Oct; 88(10):1177-85. PMID: 18719003; PMCID: PMC2557054.
    115. Sieg A, Jeanneret F, Fathi M, Hochstrasser D, Rudaz S, Veuthey JL, Guy R, Delgado-Charro MB. Extraction of amino acids by reverse iontophoresis: simulation of therapeutic monitoring in vitro. Eur J Pharm Biopharm. 2008 Nov; 70(3):908-13. PMID: 18675906.
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    116. Sylvestre JP, Díaz-Marín C, Delgado-Charro MB, Guy R. Iontophoresis of dexamethasone phosphate: competition with chloride ions. J Control Release. 2008 Oct 06; 131(1):41-6. PMID: 18662729; PMCID: PMC2574231.
    117. N'Dri-Stempfer B, Navidi WC, Guy R, Bunge AL. Optimizing metrics for the assessment of bioequivalence between topical drug products. Pharm Res. 2008 Jul; 25(7):1621-30. PMID: 18449629.
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    118. Wascotte V, Rozet E, Salvaterra A, Hubert P, Jadoul M, Guy R, Préat V. Non-invasive diagnosis and monitoring of chronic kidney disease by reverse iontophoresis of urea in vivo. Eur J Pharm Biopharm. 2008 Aug; 69(3):1077-82. PMID: 18406585.
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    119. Dias M, Naik A, Guy R, Hadgraft J, Lane ME. In vivo infrared spectroscopy studies of alkanol effects on human skin. Eur J Pharm Biopharm. 2008 Aug; 69(3):1171-5. PMID: 18406117.
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    120. Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy R. Effect of propylene glycol on ibuprofen absorption into human skin in vivo. J Pharm Sci. 2008 Jan; 97(1):185-97. PMID: 17497726.
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    121. Nixon S, Sieg A, Delgado-Charro MB, Guy R. Reverse iontophoresis of L-lactate: in vitro and in vivo studies. J Pharm Sci. 2007 Dec; 96(12):3457-65. PMID: 17506512.
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    122. Herkenne C, Alberti I, Naik A, Kalia YN, Mathy FX, Préat V, Guy R. In vivo methods for the assessment of topical drug bioavailability. Pharm Res. 2008 Jan; 25(1):87-103. PMID: 17985216; PMCID: PMC2217624.
    123. Wiedersberg S, Leopold CS, Guy R. Bioavailability and bioequivalence of topical glucocorticoids. Eur J Pharm Biopharm. 2008 Mar; 68(3):453-66. PMID: 17826047.
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    124. Trichard L, Delgado-Charro MB, Guy R, Fattal E, Bochot A. Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug. Pharm Res. 2008 Feb; 25(2):435-40. PMID: 17671830.
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    125. Mudry B, Carrupt PA, Guy R, Delgado-Charro MB. Quantitative structure-permeation relationship for iontophoretic transport across the skin. J Control Release. 2007 Sep 26; 122(2):165-72. PMID: 17707106; PMCID: PMC2082109.
    126. Kroes R, Renwick AG, Feron V, Galli CL, Gibney M, Greim H, Guy R, Lhuguenot JC, van de Sandt JJ. Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients. Food Chem Toxicol. 2007 Dec; 45(12):2533-62. PMID: 17664037.
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    127. Diaz del Consuelo I, Falson F, Guy R, Jacques Y. Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl. J Control Release. 2007 Sep 26; 122(2):135-40. PMID: 17688966.
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    128. Wascotte V, Caspers P, de Sterke J, Jadoul M, Guy R, Préat V. Assessment of the "skin reservoir" of urea by confocal Raman microspectroscopy and reverse iontophoresis in vivo. Pharm Res. 2007 Oct; 24(10):1897-901. PMID: 17497081.
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    129. Mehier-Humbert S, Yan F, Frinking P, Schneider M, Guy R, Bettinger T. Ultrasound-mediated gene delivery: influence of contrast agent on transfection. Bioconjug Chem. 2007 May-Jun; 18(3):652-62. PMID: 17419583.
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    130. Wascotte V, Delgado-Charro MB, Rozet E, Wallemacq P, Hubert P, Guy R, Préat V. Monitoring of urea and potassium by reverse iontophoresis in vitro. Pharm Res. 2007 Jun; 24(6):1131-7. PMID: 17380270.
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    131. Leichtnam ML, Rolland H, Wüthrich P, Guy R. Impact of antinucleants on transdermal delivery of testosterone from a spray. J Pharm Sci. 2007 Jan; 96(1):84-92. PMID: 16998787.
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    132. Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy R. Dermatopharmacokinetic prediction of topical drug bioavailability in vivo. J Invest Dermatol. 2007 Apr; 127(4):887-94. PMID: 17139266.
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    133. Leichtnam ML, Rolland H, Wüthrich P, Guy R. Enhancement of transdermal testosterone delivery by supersaturation. J Pharm Sci. 2006 Nov; 95(11):2373-9. PMID: 16886189.
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    134. Leichtnam ML, Rolland H, Wüthrich P, Guy R. Formulation and evaluation of a testosterone transdermal spray. J Pharm Sci. 2006 Aug; 95(8):1693-702. PMID: 16795012.
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    135. Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy R. Pig ear skin ex vivo as a model for in vivo dermatopharmacokinetic studies in man. Pharm Res. 2006 Aug; 23(8):1850-6. PMID: 16841197.
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    136. Abla N, Naik A, Guy R, Kalia YN. Topical iontophoresis of valaciclovir hydrochloride improves cutaneous aciclovir delivery. Pharm Res. 2006 Aug; 23(8):1842-9. PMID: 16850271.
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    137. Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy R. Ibuprofen transport into and through skin from topical formulations: in vitro-in vivo comparison. J Invest Dermatol. 2007 Jan; 127(1):135-42. PMID: 16858418.
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    138. Leichtnam ML, Rolland H, Wüthrich P, Guy R. Testosterone hormone replacement therapy: state-of-the-art and emerging technologies. Pharm Res. 2006 Jun; 23(6):1117-32. PMID: 16755346.
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    139. Schuetz YB, Carrupt PA, Naik A, Guy R, Kalia YN. Structure-permeation relationships for the non-invasive transdermal delivery of cationic peptides by iontophoresis. Eur J Pharm Sci. 2006 Sep; 29(1):53-9. PMID: 16837178.
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    140. Leichtnam ML, Rolland H, Wüthrich P, Guy R. Identification of penetration enhancers for testosterone transdermal delivery from spray formulations. J Control Release. 2006 Jun 12; 113(1):57-62. PMID: 16677734.
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    141. Mudry B, Guy R, Delgado-Charro MB. Electromigration of ions across the skin: determination and prediction of transport numbers. J Pharm Sci. 2006 Mar; 95(3):561-9. PMID: 16419050.
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    142. Mudry B, Guy R, Begoña Delgado-Charro M. Prediction of iontophoretic transport across the skin. J Control Release. 2006 Apr 10; 111(3):362-7. PMID: 16488047.
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    143. Mudry B, Guy R, Delgado-Charro MB. Transport numbers in transdermal iontophoresis. Biophys J. 2006 Apr 15; 90(8):2822-30. PMID: 16443654; PMCID: PMC1414545.
    144. Diaz Del Consuelo I, Pizzolato GP, Falson F, Guy R, Jacques Y. Evaluation of pig esophageal mucosa as a permeability barrier model for buccal tissue. J Pharm Sci. 2005 Dec; 94(12):2777-88. PMID: 16258996.
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    145. Abla N, Geiser L, Mirgaldi M, Naik A, Veuthey JL, Guy R, Kalia YN. Capillary zone electrophoresis for the estimation of transdermal iontophoretic mobility. J Pharm Sci. 2005 Dec; 94(12):2667-75. PMID: 16258982.
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    146. Schuetz YB, Naik A, Guy R, Vuaridel E, Kalia YN. Transdermal iontophoretic delivery of triptorelin in vitro. J Pharm Sci. 2005 Oct; 94(10):2175-82. PMID: 16136544.
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    147. Abla N, Naik A, Guy R, Kalia YN. Effect of charge and molecular weight on transdermal peptide delivery by iontophoresis. Pharm Res. 2005 Dec; 22(12):2069-78. PMID: 16170597.
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    148. Abla N, Naik A, Guy R, Kalia YN. Contributions of electromigration and electroosmosis to peptide iontophoresis across intact and impaired skin. J Control Release. 2005 Nov 28; 108(2-3):319-30. PMID: 16169627.
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    149. Schuetz YB, Naik A, Guy R, Kalia YN. Effect of amino acid sequence on transdermal iontophoretic peptide delivery. Eur J Pharm Sci. 2005 Dec; 26(5):429-37. PMID: 16143501.
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    150. Diaz Del Consuelo I, Falson F, Guy R, Jacques Y. Transport of fentanyl through pig buccal and esophageal epithelia in vitro: influence of concentration and vehicle pH. Pharm Res. 2005 Sep; 22(9):1525-9. PMID: 16132365.
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    151. Schuetz YB, Naik A, Guy R, Vuaridel E, Kalia YN. Transdermal iontophoretic delivery of vapreotide acetate across porcine skin in vitro. Pharm Res. 2005 Aug; 22(8):1305-12. PMID: 16078140.
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    152. Diaz-Del Consuelo I, Jacques Y, Pizzolato GP, Guy R, Falson F. Comparison of the lipid composition of porcine buccal and esophageal permeability barriers. Arch Oral Biol. 2005 Dec; 50(12):981-7. PMID: 15955526.
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    153. Touraille GD, McCarley KD, Bunge AL, Marty JP, Guy R. Percutaneous absorption of 4-cyanophenol from freshly contaminated soil in vitro: effects of soil loading and contamination concentration. Environ Sci Technol. 2005 May 15; 39(10):3723-31. PMID: 15954226.
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    154. Schuetz YB, Naik A, Guy R, Kalia YN. Emerging strategies for the transdermal delivery of peptide and protein drugs. Expert Opin Drug Deliv. 2005 May; 2(3):533-48. PMID: 16296773.
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    155. Mehier-Humbert S, Guy R. Physical methods for gene transfer: improving the kinetics of gene delivery into cells. Adv Drug Deliv Rev. 2005 Apr 05; 57(5):733-53. PMID: 15757758.
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    156. Mehier-Humbert S, Bettinger T, Yan F, Guy R. Plasma membrane poration induced by ultrasound exposure: implication for drug delivery. J Control Release. 2005 May 05; 104(1):213-22. PMID: 15866347.
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    157. Mehier-Humbert S, Bettinger T, Yan F, Guy R. Ultrasound-mediated gene delivery: kinetics of plasmid internalization and gene expression. J Control Release. 2005 May 05; 104(1):203-11. PMID: 15866346.
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    158. Sieg A, Guy R, Delgado-Charro MB. Noninvasive and minimally invasive methods for transdermal glucose monitoring. Diabetes Technol Ther. 2005 Feb; 7(1):174-97. PMID: 15738715.
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    159. Wascotte V, Leboulanger B, Guy R, Begoña Delgado-Charro M. Reverse iontophoresis of lithium: electrode formulation using a thermoreversible polymer. Eur J Pharm Biopharm. 2005 Jan; 59(1):237-40. PMID: 15567322.
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    160. Sekkat N, Kalia YN, Guy R. Development of an in vitro model for premature neonatal skin: biophysical characterization using transepidermal water loss. J Pharm Sci. 2004 Dec; 93(12):2936-40. PMID: 15459948.
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    161. Merclin N, Bender J, Sparr E, Guy R, Ehrsson H, Engström S. Transdermal delivery from a lipid sponge phase--iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester. J Control Release. 2004 Nov 24; 100(2):191-8. PMID: 15544867.
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    162. Sieg A, Guy R, Delgado-Charro MB. Simultaneous extraction of urea and glucose by reverse iontophoresis in vivo. Pharm Res. 2004 Oct; 21(10):1805-10. PMID: 15553226.
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    163. Alvarez-Román R, Naik A, Kalia YN, Guy R, Fessi H. Enhancement of topical delivery from biodegradable nanoparticles. Pharm Res. 2004 Oct; 21(10):1818-25. PMID: 15553228.
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    164. Alvarez-Román R, Naik A, Kalia YN, Guy R, Fessi H. Skin penetration and distribution of polymeric nanoparticles. J Control Release. 2004 Sep 14; 99(1):53-62. PMID: 15342180.
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    165. Alvarez-Román R, Naik A, Kalia YN, Fessi H, Guy R. Visualization of skin penetration using confocal laser scanning microscopy. Eur J Pharm Biopharm. 2004 Sep; 58(2):301-16. PMID: 15296957.
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    166. Sieg A, Guy R, Delgado-Charro MB. Electroosmosis in transdermal iontophoresis: implications for noninvasive and calibration-free glucose monitoring. Biophys J. 2004 Nov; 87(5):3344-50. PMID: 15339817; PMCID: PMC1304802.
    167. Leboulanger B, Guy R, Delgado-Charro MB. Non-invasive monitoring of phenytoin by reverse iontophoresis. Eur J Pharm Sci. 2004 Aug; 22(5):427-33. PMID: 15265512.
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    168. Sekkat N, Kalia YN, Guy R. Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates. Pharm Res. 2004 Aug; 21(8):1390-7. PMID: 15359573.
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    169. Leboulanger B, Fathi M, Guy R, Delgado-Charro MB. Reverse iontophoresis as a noninvasive tool for lithium monitoring and pharmacokinetic profiling. Pharm Res. 2004 Jul; 21(7):1214-22. PMID: 15290862.
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    170. Leboulanger B, Aubry JM, Bondolfi G, Guy R, Delgado-Charro MB. Lithium monitoring by reverse iontophoresis in vivo. Clin Chem. 2004 Nov; 50(11):2091-100. PMID: 15192031.
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    171. Leboulanger B, Guy R, Delgado-Charro MB. Reverse iontophoresis for non-invasive transdermal monitoring. Physiol Meas. 2004 Jun; 25(3):R35-50. PMID: 15253111.
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    172. Sieg A, Guy R, Delgado-Charro MB. Noninvasive glucose monitoring by reverse iontophoresis in vivo: application of the internal standard concept. Clin Chem. 2004 Aug; 50(8):1383-90. PMID: 15155544.
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    173. Kalia YN, Naik A, Garrison J, Guy R. Iontophoretic drug delivery. Adv Drug Deliv Rev. 2004 Mar 27; 56(5):619-58. PMID: 15019750.
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    174. Curdy C, Naik A, Kalia YN, Alberti I, Guy R. Non-invasive assessment of the effect of formulation excipients on stratum corneum barrier function in vivo. Int J Pharm. 2004 Mar 01; 271(1-2):251-6. PMID: 15129992.
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    175. Lopez RF, Lange N, Guy R, Bentley MV. Photodynamic therapy of skin cancer: controlled drug delivery of 5-ALA and its esters. Adv Drug Deliv Rev. 2004 Jan 13; 56(1):77-94. PMID: 14706446.
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    176. Geinoz S, Guy R, Testa B, Carrupt PA. Quantitative structure-permeation relationships (QSPeRs) to predict skin permeation: a critical evaluation. Pharm Res. 2004 Jan; 21(1):83-92. PMID: 14984261.
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    177. Hadgraft J, Guy R. Biotechnological aspects of transport across human skin. Biotechnol Genet Eng Rev. 2004; 21:183-93. PMID: 17017032.
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    178. Sieg A, Guy R, Delgado-Charro MB. Reverse iontophoresis for noninvasive glucose monitoring: the internal standard concept. J Pharm Sci. 2003 Nov; 92(11):2295-302. PMID: 14603514.
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    179. Delgado-Charro MB, Guy R. Transdermal reverse iontophoresis of valproate: a noninvasive method for therapeutic drug monitoring. Pharm Res. 2003 Sep; 20(9):1508-13. PMID: 14567648.
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    180. Merino G, Kalia YN, Guy R. Ultrasound-enhanced transdermal transport. J Pharm Sci. 2003 Jun; 92(6):1125-37. PMID: 12761802.
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    181. Alvarez-Román R, Merino G, Kalia YN, Naik A, Guy R. Skin permeability enhancement by low frequency sonophoresis: lipid extraction and transport pathways. J Pharm Sci. 2003 Jun; 92(6):1138-46. PMID: 12761803.
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    182. Lopez RF, Bentley MV, Delgado-Charro MB, Salomon D, van den Bergh H, Lange N, Guy R. Enhanced delivery of 5-aminolevulinic acid esters by iontophoresis in vitro. Photochem Photobiol. 2003 Mar; 77(3):304-8. PMID: 12685659.
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    183. Lopez RF, Bentley MV, Begoña Delgado-Charro M, Guy R. Optimization of aminolevulinic acid delivery by iontophoresis. J Control Release. 2003 Feb 14; 88(1):65-70. PMID: 12586504.
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    184. Merino G, Kalia YN, Delgado-Charro MB, Potts RO, Guy R. Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis. J Control Release. 2003 Feb 14; 88(1):85-94. PMID: 12586506.
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    185. Geinoz S, Rey S, Boss G, Bunge AL, Guy R, Carrupt PA, Reist M, Testa B. Quantitative structure-permeation relationships for solute transport across silicone membranes. Pharm Res. 2002 Nov; 19(11):1622-9. PMID: 12458667.
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    186. Sekkat N, Kalia YN, Guy R. Biophysical study of porcine ear skin in vitro and its comparison to human skin in vivo. J Pharm Sci. 2002 Nov; 91(11):2376-81. PMID: 12379922.
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    187. Sekkat N, Naik A, Kalia YN, Glikfeld P, Guy R. Reverse iontophoretic monitoring in premature neonates: feasibility and potential. J Control Release. 2002 May 17; 81(1-2):83-9. PMID: 11992681.
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    188. Reddy MB, Stinchcomb AL, Guy R, Bunge AL. Determining dermal absorption parameters in vivo from tape strip data. Pharm Res. 2002 Mar; 19(3):292-8. PMID: 11934236.
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    189. Dujardin N, Staes E, Kalia Y, Clarys P, Guy R, Préat V. In vivo assessment of skin electroporation using square wave pulses. J Control Release. 2002 Feb 19; 79(1-3):219-27. PMID: 11853933.
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    190. Veuillez F, Rieg FF, Guy R, Deshusses J, Buri P. Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity. Int J Pharm. 2002 Jan 01; 231(1):1-9. PMID: 11719008.
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    191. Curdy C, Kalia YN, Guy R. Post-iontophoresis recovery of human skin impedance in vivo. Eur J Pharm Biopharm. 2002 Jan; 53(1):15-21. PMID: 11777748.
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    192. Marro D, Kalia YN, Delgado-Charro MB, Guy R. Optimizing iontophoretic drug delivery: identification and distribution of the charge-carrying species. Pharm Res. 2001 Dec; 18(12):1709-13. PMID: 11785690.
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    193. Marro D, Kalia YN, Delgado-Charro MB, Guy R. Contributions of electromigration and electroosmosis to iontophoretic drug delivery. Pharm Res. 2001 Dec; 18(12):1701-8. PMID: 11785689.
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    194. Alberti I, Kalia YN, Naik A, Guy R. Assessment and prediction of the cutaneous bioavailability of topical terbinafine, in vivo, in man. Pharm Res. 2001 Oct; 18(10):1472-5. PMID: 11697475.
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    195. Curdy C, Kalia YN, Naik A, Guy R. Piroxicam delivery into human stratum corneum in vivo: iontophoresis versus passive diffusion. J Control Release. 2001 Sep 11; 76(1-2):73-9. PMID: 11532314.
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    196. Moser K, Kriwet K, Naik A, Kalia YN, Guy R. Passive skin penetration enhancement and its quantification in vitro. Eur J Pharm Biopharm. 2001 Sep; 52(2):103-12. PMID: 11522474.
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    197. Alvarez-Román R, Barré G, Guy R, Fessi H. Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection. Eur J Pharm Biopharm. 2001 Sep; 52(2):191-5. PMID: 11522485.
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    198. Moser K, Kriwet K, Kalia YN, Guy R. Stabilization of supersaturated solutions of a lipophilic drug for dermal delivery. Int J Pharm. 2001 Aug 14; 224(1-2):169-76. PMID: 11472826.
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    199. Moser K, Kriwet K, Froehlich C, Kalia YN, Guy R. Supersaturation: enhancement of skin penetration and permeation of a lipophilic drug. Pharm Res. 2001 Jul; 18(7):1006-11. PMID: 11496937.
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    200. Moser K, Kriwet K, Kalia YN, Guy R. Enhanced skin permeation of a lipophilic drug using supersaturated formulations. J Control Release. 2001 Jun 15; 73(2-3):245-53. PMID: 11516502.
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    201. Kalia YN, Guy R. Modeling transdermal drug release. Adv Drug Deliv Rev. 2001 Jun 11; 48(2-3):159-72. PMID: 11369080.
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    202. Curdy C, Kalia YN, Guy R. Non-invasive assessment of the effects of iontophoresis on human skin in-vivo. J Pharm Pharmacol. 2001 Jun; 53(6):769-77. PMID: 11428652.
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    203. Alberti I, Kalia YN, Naik A, Bonny J, Guy R. Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo. Int J Pharm. 2001 May 21; 219(1-2):11-9. PMID: 11337162.
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    204. Moser K, Kriwet K, Froehlich C, Naik A, Kalia YN, Guy R. Permeation enhancement of a highly lipophilic drug using supersaturated systems. J Pharm Sci. 2001 May; 90(5):607-16. PMID: 11288105.
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    205. Alberti I, Kalia YN, Naik A, Bonny JD, Guy R. In vivo assessment of enhanced topical delivery of terbinafine to human stratum corneum. J Control Release. 2001 Apr 28; 71(3):319-27. PMID: 11295224.
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    206. Lopez RF, Bentley MV, Delgado-Charro MB, Guy R. Iontophoretic delivery of 5-aminolevulinic acid (ALA): effect of pH. Pharm Res. 2001 Mar; 18(3):311-5. PMID: 11442270.
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    207. Marro D, Guy R, Delgado-Charro MB. Characterization of the iontophoretic permselectivity properties of human and pig skin. J Control Release. 2001 Jan 29; 70(1-2):213-7. PMID: 11166421.
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    208. Guy R, Delgado-Charro MB, Kalia YN. Iontophoretic transport across the skin. Skin Pharmacol Appl Skin Physiol. 2001; 14 Suppl 1:35-40. PMID: 11509905.
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    209. Kalia YN, Alberti I, Naik A, Guy R. Assessment of topical bioavailability in vivo: the importance of stratum corneum thickness. Skin Pharmacol Appl Skin Physiol. 2001; 14 Suppl 1:82-6. PMID: 11509911.
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    210. Reddy MB, Guy R, Bunge AL. Does epidermal turnover reduce percutaneous penetration? Pharm Res. 2000 Nov; 17(11):1414-9. PMID: 11205736.
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    211. Kalia YN, Alberti I, Sekkat N, Curdy C, Naik A, Guy R. Normalization of stratum corneum barrier function and transepidermal water loss in vivo. Pharm Res. 2000 Sep; 17(9):1148-50. PMID: 11087050.
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    212. Nonato LB, Lund CH, Kalia YN, Guy R. Transepidermal water loss in 24 and 25 weeks gestational age infants. Acta Paediatr. 2000 Jun; 89(6):747-8. PMID: 10914980.
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    213. Guy R, Kalia YN, Delgado-Charro MB, Merino V, López A, Marro D. Iontophoresis: electrorepulsion and electroosmosis. J Control Release. 2000 Feb 14; 64(1-3):129-32. PMID: 10640651.
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    214. Curdy C, Kalia YN, Falson-Rieg F, Guy R. Recovery of human skin impedance in vivo after iontophoresis: effect of metal ions. AAPS PharmSci. 2000; 2(3):E23. PMID: 11741239; PMCID: PMC2761134.
    215. Bunge AL, Guy R, Hadgraft J. The determination of a diffusional pathlength through the stratum corneum. Int J Pharm. 1999 Oct 15; 188(1):121-4. PMID: 10528090.
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    216. Merino V, López A, Hochstrasser D, Guy R. Noninvasive sampling of phenylalanine by reverse iontophoresis. J Control Release. 1999 Aug 27; 61(1-2):65-9. PMID: 10469903.
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    217. Stinchcomb AL, Pirot F, Touraille GD, Bunge AL, Guy R. Chemical uptake into human stratum corneum in vivo from volatile and non-volatile solvents. Pharm Res. 1999 Aug; 16(8):1288-93. PMID: 10468033.
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    218. Merino V, López A, Kalia YN, Guy R. Electrorepulsion versus electroosmosis: effect of pH on the iontophoretic flux of 5-fluorouracil. Pharm Res. 1999 May; 16(5):758-61. PMID: 10350021.
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    219. Lim KC, Sun E, Bahgat M, Bucks D, Guy R, Hinz RS, Cullander C, McKerrow JH. Blockage of skin invasion by schistosome cercariae by serine protease inhibitors. Am J Trop Med Hyg. 1999 Mar; 60(3):487-92. PMID: 10466982.
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    220. Kalia YN, Pirot F, Potts RO, Guy R. Ion mobility across human stratum corneum in vivo. J Pharm Sci. 1998 Dec; 87(12):1508-11. PMID: 10189257.
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    221. Turner NG, Guy R. Visualization and quantitation of iontophoretic pathways using confocal microscopy. J Investig Dermatol Symp Proc. 1998 Aug; 3(2):136-42. PMID: 9734828.
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    222. Kalia YN, Nonato LB, Lund CH, Guy R. Development of skin barrier function in premature infants. J Invest Dermatol. 1998 Aug; 111(2):320-6. PMID: 9699737.
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    223. Turner NG, Cullander C, Guy R. Determination of the pH gradient across the stratum corneum. J Investig Dermatol Symp Proc. 1998 Aug; 3(2):110-3. PMID: 9734823.
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    224. Luzardo-Alvarez A, Rodríguez-Fernández M, Blanco-Méndez J, Guy R, Delgado-Charro MB. Iontophoretic permselectivity of mammalian skin: characterization of hairless mouse and porcine membrane models. Pharm Res. 1998 Jul; 15(7):984-7. PMID: 9688048.
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    225. Guy R, Kealey T. The effects of inflammatory cytokines on the isolated human sebaceous infundibulum. J Invest Dermatol. 1998 Apr; 110(4):410-5. PMID: 9540984.
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    226. Kalia YN, Merino V, Guy R. Transdermal drug delivery. Clinical aspects. Dermatol Clin. 1998 Apr; 16(2):289-99. PMID: 9589202.
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    227. Guy R. Iontophoresis--recent developments. J Pharm Pharmacol. 1998 Apr; 50(4):371-4. PMID: 9625480.
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    228. Pirot F, Berardesca E, Kalia YN, Singh M, Maibach HI, Guy R. Stratum corneum thickness and apparent water diffusivity: facile and noninvasive quantitation in vivo. Pharm Res. 1998 Mar; 15(3):492-4. PMID: 9563083.
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    229. Langkjaer L, Brange J, Grodsky GM, Guy R. Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment. J Control Release. 1998 Jan 23; 51(1):47-56. PMID: 9685903.
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    230. Hirvonen J, Guy R. Transdermal iontophoresis: modulation of electroosmosis by polypeptide. J Control Release. 1998 Jan 02; 50(1-3):283-9. PMID: 9685895.
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    231. Turner NG, Guy R. Iontophoretic transport pathways: dependence on penetrant physicochemical properties. J Pharm Sci. 1997 Dec; 86(12):1385-9. PMID: 9423151.
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    232. Turner NG, Ferry L, Price M, Cullander C, Guy R. Iontophoresis of poly-L-lysines: the role of molecular weight? Pharm Res. 1997 Oct; 14(10):1322-31. PMID: 9358543.
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    233. Hirvonen J, Guy R. Iontophoretic delivery across the skin: electroosmosis and its modulation by drug substances. Pharm Res. 1997 Sep; 14(9):1258-63. PMID: 9327458.
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    234. Turner NG, Kalia YN, Guy R. The effect of current on skin barrier function in vivo: recovery kinetics post-iontophoresis. Pharm Res. 1997 Sep; 14(9):1252-7. PMID: 9327457.
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    235. Merino V, Kalia YN, Guy R. Transdermal therapy and diagnosis by iontophoresis. Trends Biotechnol. 1997 Aug; 15(8):288-90. PMID: 9263476.
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    236. Pirot F, Kalia YN, Stinchcomb AL, Keating G, Bunge A, Guy R. Characterization of the permeability barrier of human skin in vivo. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1562-7. PMID: 9037093; PMCID: PMC19831.
    237. Prausnitz MR, Gimm JA, Guy R, Langer R, Weaver JC, Cullander C. Imaging regions of transport across human stratum corneum during high-voltage and low-voltage exposures. J Pharm Sci. 1996 Dec; 85(12):1363-70. PMID: 8961154.
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    238. Hirvonen J, Kalia YN, Guy R. Transdermal delivery of peptides by iontophoresis. Nat Biotechnol. 1996 Dec; 14(13):1710-3. PMID: 9634857.
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    239. Guy R. Current status and future prospects of transdermal drug delivery. Pharm Res. 1996 Dec; 13(12):1765-9. PMID: 8987069.
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    240. Kalia YN, Pirot F, Guy R. Homogeneous transport in a heterogeneous membrane: water diffusion across human stratum corneum in vivo. Biophys J. 1996 Nov; 71(5):2692-700. PMID: 8913606; PMCID: PMC1233755.
    241. Kennedy AH, Golden GM, Gay CL, Guy R, Francoeur ML, Mak VH. Stratum corneum lipids of human epidermal keratinocyte air-liquid cultures: implications for barrier function. Pharm Res. 1996 Aug; 13(8):1162-7. PMID: 8865305.
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    242. Tsai JC, Guy R, Thornfeldt CR, Gao WN, Feingold KR, Elias PM. Metabolic approaches to enhance transdermal drug delivery. 1. Effect of lipid synthesis inhibitors. J Pharm Sci. 1996 Jun; 85(6):643-8. PMID: 8773963.
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    243. Kalia YN, Nonato LB, Guy R. The effect of iontophoresis on skin barrier integrity: non-invasive evaluation by impedance spectroscopy and transepidermal water loss. Pharm Res. 1996 Jun; 13(6):957-60. PMID: 8792440.
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    244. Rodríguez Bayón AM, Guy R. Iontophoresis of nafarelin across human skin in vitro. Pharm Res. 1996 May; 13(5):798-800. PMID: 8860440.
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    245. van der Geest R, Hueber F, Szoka FC, Guy R. Iontophoresis of bases, nucleosides, and nucleotides. Pharm Res. 1996 Apr; 13(4):553-8. PMID: 8710745.
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    246. Rao G, Guy R, Glikfeld P, LaCourse WR, Leung L, Tamada J, Potts RO, Azimi N. Reverse iontophoresis: noninvasive glucose monitoring in vivo in humans. Pharm Res. 1995 Dec; 12(12):1869-73. PMID: 8786958.
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    247. Kalia YN, Guy R. The electrical characteristics of human skin in vivo. Pharm Res. 1995 Nov; 12(11):1605-13. PMID: 8592657.
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    248. Potts RO, Guy R. A predictive algorithm for skin permeability: the effects of molecular size and hydrogen bond activity. Pharm Res. 1995 Nov; 12(11):1628-33. PMID: 8592661.
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    249. Guy R. A sweeter life for diabetics? Nat Med. 1995 Nov; 1(11):1132-3. PMID: 7584978.
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    250. Aspe E, Guy R, Lee WA, Kennedy JA, Visor GC, Ennis RD. Optimization of in vitro flux through hairless mouse skin of cidofovir, a potent nucleotide analog. J Pharm Sci. 1995 Jun; 84(6):750-4. PMID: 7562417.
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    251. Guy R. Percutaneous absorption: physical chemistry meets the skin. Curr Probl Dermatol. 1995; 22:132-8. PMID: 7587314.
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    252. Gay CL, Guy R, Golden GM, Mak VH, Francoeur ML. Characterization of low-temperature (i.e., < 65 degrees C) lipid transitions in human stratum corneum. J Invest Dermatol. 1994 Aug; 103(2):233-9. PMID: 8040615.
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    253. Delgado-Charro MB, Guy R. Characterization of convective solvent flow during iontophoresis. Pharm Res. 1994 Jul; 11(7):929-35. PMID: 7937551.
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    254. Singh BM, Prescott JJ, Guy R, Walford S, Murphy M, Wise PH. Effect of advertising on awareness of symptoms of diabetes among the general public: the British Diabetic Association Study. BMJ. 1994 Mar 05; 308(6929):632-6. PMID: 8148713; PMCID: PMC2539721.
    255. Rao G, Glikfeld P, Guy R. Reverse iontophoresis: development of a noninvasive approach for glucose monitoring. Pharm Res. 1993 Dec; 10(12):1751-5. PMID: 8302761.
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    256. Higo N, Naik A, Bommannan DB, Potts RO, Guy R. Validation of reflectance infrared spectroscopy as a quantitative method to measure percutaneous absorption in vivo. Pharm Res. 1993 Oct; 10(10):1500-6. PMID: 8272414.
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    257. Kim A, Green PG, Rao G, Guy R. Convective solvent flow across the skin during iontophoresis. Pharm Res. 1993 Sep; 10(9):1315-20. PMID: 8234169.
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    258. Bucks DA, Hostynek JJ, Hinz RS, Guy R. Uptake of two zwitterionic surfactants into human skin in vivo. Toxicol Appl Pharmacol. 1993 Jun; 120(2):224-7. PMID: 8511791.
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    259. Guy R, Potts RO. Penetration of industrial chemicals across the skin: a predictive model. Am J Ind Med. 1993 May; 23(5):711-9. PMID: 8506849.
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    260. Potts RO, Guy R. The influence of molecular volume and hydrogen-bonding on peptide transport across epithelial membranes. Pharm Res. 1993 Apr; 10(4):635-7. PMID: 8483853.
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    261. Guy R, Ridden C, Barth J, Kealey T. Isolation and maintenance of the human pilosebaceous duct: 13-cis retinoic acid acts directly on the duct in vitro. Br J Dermatol. 1993 Mar; 128(3):242-8. PMID: 7682433.
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    262. Hostýnek JJ, Hinz RS, Lorence CR, Price M, Guy R. Metals and the skin. Crit Rev Toxicol. 1993; 23(2):171-235. PMID: 8329115.
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    263. Tur E, Tamir A, Guy R. Cutaneous blood flow in gestational hypertension and normal pregnancy. J Invest Dermatol. 1992 Sep; 99(3):310-4. PMID: 1512468.
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    264. Bommannan D, Menon GK, Okuyama H, Elias PM, Guy R. Sonophoresis. II. Examination of the mechanism(s) of ultrasound-enhanced transdermal drug delivery. Pharm Res. 1992 Aug; 9(8):1043-7. PMID: 1409375.
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    265. Ridout G, Houk J, Guy R, Santus GC, Hadgraft J, Hall LL. An evaluation of structure-penetration relationships in percutaneous absorption. Farmaco. 1992 Jun; 47(6):869-92. PMID: 1388606.
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    266. Hadgraft J, Walters KA, Guy R. Epidermal lipids and topical drug delivery. Semin Dermatol. 1992 Jun; 11(2):139-44. PMID: 1498017.
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    267. Guy R, Potts RO. Structure-permeability relationships in percutaneous penetration. J Pharm Sci. 1992 Jun; 81(6):603-4. PMID: 1522504.
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    268. Potts RO, Guy R. Predicting skin permeability. Pharm Res. 1992 May; 9(5):663-9. PMID: 1608900.
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    269. Hori M, Maibach HI, Guy R. Enhancement of propranolol hydrochloride and diazepam skin absorption in vitro. II: Drug, vehicle, and enhancer penetration kinetics. J Pharm Sci. 1992 Apr; 81(4):330-3. PMID: 1501066.
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    270. Bommannan D, Okuyama H, Stauffer P, Guy R. Sonophoresis. I. The use of high-frequency ultrasound to enhance transdermal drug delivery. Pharm Res. 1992 Apr; 9(4):559-64. PMID: 1495903.
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    271. Higo N, Hinz RS, Lau DT, Benet LZ, Guy R. Cutaneous metabolism of nitroglycerin in vitro. II. Effects of skin condition and penetration enhancement. Pharm Res. 1992 Mar; 9(3):303-6. PMID: 1614960.
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    272. Higo N, Hinz RS, Lau DT, Benet LZ, Guy R. Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin. Pharm Res. 1992 Feb; 9(2):187-90. PMID: 1553339.
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    273. Guy R, Potts RO, Francoeur ML. Skin barrier function and the mechanism(s) of percutaneous penetration. Acta Pharm Nord. 1992; 4(2):115. PMID: 1388754.
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    274. Kikkoji T, Gumbleton M, Higo N, Guy R, Benet LZ. Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro. Pharm Res. 1991 Oct; 8(10):1231-7. PMID: 1796039.
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    275. Hinz RS, Lorence CR, Hodson CD, Hansch C, Hall LL, Guy R. Percutaneous penetration of para-substituted phenols in vitro. Fundam Appl Toxicol. 1991 Oct; 17(3):575-83. PMID: 1794659.
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    276. Green PG, Hinz RS, Cullander C, Yamane G, Guy R. Iontophoretic delivery of amino acids and amino acid derivatives across the skin in vitro. Pharm Res. 1991 Sep; 8(9):1113-20. PMID: 1788156.
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    277. Green PG, Hinz RS, Kim A, Szoka FC, Guy R. Iontophoretic delivery of a series of tripeptides across the skin in vitro. Pharm Res. 1991 Sep; 8(9):1121-7. PMID: 1788157.
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    278. Shah VP, Flynn GL, Guy R, Maibach HI, Schaefer H, Skelly JP, Wester RC, Yacobi A. In vivo percutaneous penetration/absorption, Washington, D.C., May 1989. Pharm Res. 1991 Aug; 8(8):1071-5. PMID: 1924164.
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    279. Mak VH, Potts RO, Guy R. Does hydration affect intercellular lipid organization in the stratum corneum? Pharm Res. 1991 Aug; 8(8):1064-5. PMID: 1924161.
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    280. Cullander C, Guy R. Sites of iontophoretic current flow into the skin: identification and characterization with the vibrating probe electrode. J Invest Dermatol. 1991 Jul; 97(1):55-64. PMID: 2056194.
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    281. Mak VH, Cumpstone MB, Kennedy AH, Harmon CS, Guy R, Potts RO. Barrier function of human keratinocyte cultures grown at the air-liquid interface. J Invest Dermatol. 1991 Mar; 96(3):323-7. PMID: 2002253.
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    282. Tur E, Maibach HI, Guy R. Percutaneous penetration of methyl nicotinate at three anatomic sites: evidence for an appendageal contribution to transport? Skin Pharmacol. 1991; 4(4):230-4. PMID: 1789984.
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    283. Shah VP, Flynn GL, Guy R, Maibach HI, Schaefer H, Skelly JP, Wester RC, Yacobi A. Workshop report on in vivo percutaneous penetration/absorption. Washington D.C., May 1-3, 1989. Skin Pharmacol. 1991; 4(3):220-8. PMID: 1685087.
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    284. Potts RO, Mak VH, Guy R, Francoeur ML. Strategies to enhance permeability via stratum corneum lipid pathways. Adv Lipid Res. 1991; 24:173-210. PMID: 1763712.
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    285. Hori M, Satoh S, Maibach HI, Guy R. Enhancement of propranolol hydrochloride and diazepam skin absorption in vitro: effect of enhancer lipophilicity. J Pharm Sci. 1991 Jan; 80(1):32-5. PMID: 2013847.
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    286. Ridout G, Hinz RS, Hostynek JJ, Reddy AK, Wiersema RJ, Hodson CD, Lorence CR, Guy R. The effects of zwitterionic surfactants on skin barrier function. Fundam Appl Toxicol. 1991 Jan; 16(1):41-50. PMID: 1826892.
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    287. Hori M, Ohtsuka S, Sunami M, Guy R, Maibach HI. Cutaneous pharmacodynamics of transdermally delivered isosorbide dinitrate. Pharm Res. 1990 Dec; 7(12):1298-301. PMID: 2095569.
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    288. Surber C, Wilhelm KP, Hori M, Maibach HI, Guy R. Optimization of topical therapy: partitioning of drugs into stratum corneum. Pharm Res. 1990 Dec; 7(12):1320-4. PMID: 2095573.
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    289. Berner B, Wilson DR, Steffens RJ, Mazzenga GC, Hinz R, Guy R, Maibach HI. The relationship between pKa and skin irritation for a series of basic penetrants in man. Fundam Appl Toxicol. 1990 Nov; 15(4):760-6. PMID: 2086317.
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    290. Bommannan D, Potts RO, Guy R. Examination of stratum corneum barrier function in vivo by infrared spectroscopy. J Invest Dermatol. 1990 Oct; 95(4):403-8. PMID: 2212725.
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    291. Mak VH, Potts RO, Guy R. Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy. Pharm Res. 1990 Aug; 7(8):835-41. PMID: 2235880.
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    292. Surber C, Wilhelm KP, Maibach HI, Hall LL, Guy R. Partitioning of chemicals into human stratum corneum: implications for risk assessment following dermal exposure. Fundam Appl Toxicol. 1990 Jul; 15(1):99-107. PMID: 2373304.
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    293. Bucks DA, Hinz RS, Sarason R, Maibach HI, Guy R. In vivo percutaneous absorption of chemicals: a multiple dose study in rhesus monkeys. Food Chem Toxicol. 1990 Feb; 28(2):129-32. PMID: 2341090.
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    294. Roskos KV, Bircher AJ, Maibach HI, Guy R. Pharmacodynamic measurements of methyl nicotinate percutaneous absorption: the effect of aging on microcirculation. Br J Dermatol. 1990 Feb; 122(2):165-71. PMID: 2317445.
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    295. Roskos KV, Maibach HI, Guy R. The effect of aging on percutaneous absorption in man. J Pharmacokinet Biopharm. 1989 Dec; 17(6):617-30. PMID: 2635737.
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    296. Glikfeld P, Hinz RS, Guy R. Noninvasive sampling of biological fluids by iontophoresis. Pharm Res. 1989 Nov; 6(11):988-90. PMID: 2594693.
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    297. Roskos KV, Guy R. Assessment of skin barrier function using transepidermal water loss: effect of age. Pharm Res. 1989 Nov; 6(11):949-53. PMID: 2594686.
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    298. Hinz RS, Hodson CD, Lorence CR, Guy R. In vitro percutaneous penetration: evaluation of the utility of hairless mouse skin. J Invest Dermatol. 1989 Jul; 93(1):87-91. PMID: 2746008.
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    299. Ashworth J, Coady AT, Guy R, Breathnach SM. Brawny cutaneous induration and granulomatous panniculitis in large cell non-Hodgkin's (T suppressor/cytotoxic cell) lymphoma. Br J Dermatol. 1989 Apr; 120(4):563-9. PMID: 2786426.
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    300. Gean CJ, Tur E, Maibach HI, Guy R. Cutaneous responses to topical methyl nicotinate in black, oriental, and caucasian subjects. Arch Dermatol Res. 1989; 281(2):95-8. PMID: 2774642.
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    301. Guy R, Hadgraft J. Physicochemical aspects of percutaneous penetration and its enhancement. Pharm Res. 1988 Dec; 5(12):753-8. PMID: 3247284.
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    302. Berner B, Wilson DR, Guy R, Mazzenga GC, Clarke FH, Maibach HI. The relationship of pKa and acute skin irritation in man. Pharm Res. 1988 Oct; 5(10):660-3. PMID: 3244620.
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    303. Ryatt KS, Mobayen M, Stevenson JM, Maibach HI, Guy R. Methodology to measure the transient effect of occlusion on skin penetration and stratum corneum hydration in vivo. Br J Dermatol. 1988 Sep; 119(3):307-12. PMID: 3179203.
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    304. Bucks DA, McMaster JR, Maibach HI, Guy R. Bioavailability of topically administered steroids: a "mass balance" technique. J Invest Dermatol. 1988 Jul; 91(1):29-33. PMID: 3385214.
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    305. Glikfeld P, Cullander C, Hinz RS, Guy R. A new system for in vitro studies of iontophoresis. Pharm Res. 1988 Jul; 5(7):443-6. PMID: 3247315.
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    306. Bucks DA, Maibach HI, Guy R. Mass balance and dose accountability in percutaneous absorption studies: development of a nonocclusive application system. Pharm Res. 1988 May; 5(5):313-5. PMID: 3244642.
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    307. Bucks DA, McMaster JR, Guy R, Maibach HI. Percutaneous absorption of hydroquinone in humans: effect of 1-dodecylazacycloheptan-2-one (azone) and the 2-ethylhexyl ester of 4-(dimethylamino)benzoic acid (Escalol 507). J Toxicol Environ Health. 1988; 24(3):279-89. PMID: 3260963.
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    308. Khan A, Schall LM, Tur E, Maibach HI, Guy R. Blood flow in psoriatic skin lesions: the effect of treatment. Br J Dermatol. 1987 Aug; 117(2):193-201. PMID: 2958077.
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    309. Guy R, Hadgraft J, Bucks DA. Transdermal drug delivery and cutaneous metabolism. Xenobiotica. 1987 Mar; 17(3):325-43. PMID: 3107225.
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    310. Knepp VM, Hadgraft J, Guy R. Transdermal drug delivery: problems and possibilities. Crit Rev Ther Drug Carrier Syst. 1987; 4(1):13-37. PMID: 3315235.
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    311. Guy R, Carlström EM, Bucks DA, Hinz RS, Maibach HI. Percutaneous penetration of nicotinates: in vivo and in vitro measurements. J Pharm Sci. 1986 Oct; 75(10):968-72. PMID: 3795027.
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    312. Beastall J, Guy R, Hadgraft J, Wilding I. The influence of urea on percutaneous absorption. Pharm Res. 1986 Oct; 3(5):294-7. PMID: 24271713.
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    313. Guy RH, Guy R, Maibach HI, Shah VP. The bioavailability of dermatological and other topically administered drugs. Pharm Res. 1986 Oct; 3(5):253-62. PMID: 24271707.
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    314. Roskos KV, Guy R, Maibach HI. Percutaneous absorption in the aged. Dermatol Clin. 1986 Jul; 4(3):455-65. PMID: 3521990.
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    315. Ryatt KS, Stevenson JM, Maibach HI, Guy R. Pharmacodynamic measurement of percutaneous penetration enhancement in vivo. J Pharm Sci. 1986 Apr; 75(4):374-7. PMID: 2941564.
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    316. Guy R, Tur E, Schall LM, Elamir S, Maibach HI. Determination of vehicle effects on percutaneous absorption by laser Doppler velocimetry. Arch Dermatol Res. 1986; 278(6):500-2. PMID: 2947545.
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    317. Bucks DA, Maibach HI, Guy R. Percutaneous absorption of steroids: effect of repeated application. J Pharm Sci. 1985 Dec; 74(12):1337-9. PMID: 4087204.
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    318. Young AR, Guy R, Maibach HI. Laser Doppler velocimetry to quantify UV-B induced increase in human skin blood flow. Photochem Photobiol. 1985 Oct; 42(4):385-90. PMID: 4089026.
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    319. Guy R, Hadgraft J. Pharmacokinetic interpretation of the plasma levels of clonidine following transdermal delivery. J Pharm Sci. 1985 Sep; 74(9):1016-8. PMID: 4067843.
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    320. Guy R, Hadgraft J. Kinetic analysis of transdermal nitroglycerin delivery. Pharm Res. 1985 Sep; 2(5):206-11. PMID: 24272837.
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    321. Tur E, Maibach HI, Guy R. Spatial variability of vasodilatation in human forearm skin. Br J Dermatol. 1985 Aug; 113(2):197-203. PMID: 4027187.
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    322. Guy R, Tur E, Bjerke S, Maibach HI. Are there age and racial differences to methyl nicotinate-induced vasodilatation in human skin? J Am Acad Dermatol. 1985 Jun; 12(6):1001-6. PMID: 3159763.
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    323. Guy R, Hadgraft J, Maibach HI. Percutaneous absorption in man: a kinetic approach. Toxicol Appl Pharmacol. 1985 Mar 30; 78(1):123-9. PMID: 4035664.
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    324. Guy R, Tur E, Maibach HI. Optical techniques for monitoring cutaneous microcirculation. Recent applications. Int J Dermatol. 1985 Mar; 24(2):88-94. PMID: 3157651.
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    325. Zackheim HS, Tur E, Guy R. Regional blood flow and mycosis fungoides. J Am Acad Dermatol. 1985 Mar; 12(3):578-80. PMID: 3989018.
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    326. Drouard V, Wilson DR, Maibach HI, Guy R. Quantitative assessment of UV-induced changes in microcirculatory flow by laser Doppler velocimetry. J Invest Dermatol. 1984 Sep; 83(3):188-92. PMID: 6470523.
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    327. Guy R, Hadgraft J. Prediction of drug disposition kinetics in skin and plasma following topical administration. J Pharm Sci. 1984 Jul; 73(7):883-7. PMID: 6470948.
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    328. Wester RC, Maibach HI, Guy R, Novak E. Minoxidil stimulates cutaneous blood flow in human balding scalps: pharmacodynamics measured by laser Doppler velocimetry and photopulse plethysmography. J Invest Dermatol. 1984 May; 82(5):515-7. PMID: 6239893.
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    329. Guy R, Tur E, Bugatto B, Gaebel C, Sheiner LB, Maibach HI. Pharmacodynamic measurements of methyl nicotinate percutaneous absorption. Pharm Res. 1984 Mar; 1(2):76-81. PMID: 24277216.
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    330. Guy R, Maibach HI. Correction factors for determining body exposure from forearm percutaneous absorption data. J Appl Toxicol. 1984 Feb; 4(1):26-8. PMID: 6715780.
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    331. Guy R, Hinz RS, Amantea M. Solute transport and perturbation at liquid/liquid interfaces. Faraday Discuss Chem Soc. 1984; (77):127-37. PMID: 6526077.
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    332. Guy R, Maibach HI. Drug delivery to local subcutaneous structures following topical administration. J Pharm Sci. 1983 Dec; 72(12):1375-80. PMID: 6363673.
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    333. Tur E, Tur M, Maibach HI, Guy R. Basal perfusion of the cutaneous microcirculation: measurements as a function of anatomic position. J Invest Dermatol. 1983 Nov; 81(5):442-6. PMID: 6631055.
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    334. Guy R, Wester RC, Tur E, Maibach HI. Noninvasive assessments of the percutaneous absorption of methyl nicotinate in humans. J Pharm Sci. 1983 Sep; 72(9):1077-9. PMID: 6631699.
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    335. Tur E, Guy R, Tur M, Maibach HI. Noninvasive assessment of local nicotinate pharmacodynamics by photoplethysmography. J Invest Dermatol. 1983 Jun; 80(6):499-503. PMID: 6854050.
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    336. Guy R, Hadgraft J. Physicochemical interpretation of the pharmacokinetics of percutaneous absorption. J Pharmacokinet Biopharm. 1983 Apr; 11(2):189-203. PMID: 6886974.
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    337. Wester RC, Maibach HI, Bucks DA, Guy R. Malathion percutaneous absorption after repeated administration to man. Toxicol Appl Pharmacol. 1983 Mar 30; 68(1):116-9. PMID: 6845371.
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    338. Fleming R, Guy R, Hadgraft J. Kinetics and thermodynamics of interfacial transfer. J Pharm Sci. 1983 Feb; 72(2):142-5. PMID: 6834250.
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    339. Guy R, Hadgraft J, Taylor MJ, Kellaway IW. Release of non-electrolytes from liposomes. J Pharm Pharmacol. 1983 Jan; 35(1):12-4. PMID: 6131957.
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    340. Amantea M, Tur E, Maibach HI, Guy R. Preliminary skin blood flow measurements appear unsuccessful for assessing topical corticosteroid effect. Arch Dermatol Res. 1983; 275(6):419-20. PMID: 6660915.
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    341. Cadman AD, Fleming R, Guy R. Diffusion of lysozyme chloride in water and aqueous potassium chloride solutions. Biophys J. 1982 Mar; 37(3):569-74. PMID: 7074186; PMCID: PMC1328842.
    342. Guy R, Maibach HI. Rapid radial transport of methyl nicotinate in the dermis. Arch Dermatol Res. 1982; 273(1-2):91-5. PMID: 7184475.
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    343. Guy R, Hadgraft J. Theoretical comparison of release rates of drugs into sink and nonsink conditions. J Pharm Sci. 1981 Nov; 70(11):1243-5. PMID: 7299670.
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