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Robert Newberry, PhD

Title(s)Postdoctoral Scholar, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Emailrobert.newberry@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    University of Wisconsin-MadisonPhD2016Chemistry
    The University of Texas at AustinBS2011Biochemistry
    The University of Texas at AustinBA2011Liberal Arts
    Collapse Awards and Honors
    University of California, San Francisco2016  - 2017Institutional Research Service Award
    University of Wisconsin-Madison2014  - 2015Division of Organic Chemistry Graduate Fellowship, American Chemical Society
    University of Wisconsin-Madison2012  - 2014Biotechnology Training Program Fellowship

    Collapse Overview 
    Collapse Overview
    I am broadly interested in how the intrinsic, chemical properties and features of proteins bias them toward specific structures, particularly the amyloid state implicated in many neurodegenerative disorders. My work integrates approaches and perspectives from the fields of biophysics and chemical biology to dissect the determinants of folding and misfolding in proteins linked to human diseases like Alzheimer's or Parkinson's. Understanding what makes proteins susceptible or resistant to misfolding will inform strategies for targeted intervention.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanistic Basis for Differential Pathology of alpha-Synuclein Conformational Strains
    Program for Breakthrough Biomedical Research Jul 1, 2018 - Jun 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Newberry RW, Raines RT. The n?p* Interaction. Acc Chem Res. 2017 08 15; 50(8):1838-1846. PMID: 28735540.
      View in: PubMed
    2. Newberry RW, Raines RT. A prevalent intraresidue hydrogen bond stabilizes proteins. Nat Chem Biol. 2016 Dec; 12(12):1084-1088. PMID: 27748749.
      View in: PubMed
    3. Newberry RW, Orke SJ, Raines RT. n?p* Interactions Are Competitive with Hydrogen Bonds. Org Lett. 2016 08 05; 18(15):3614-7. PMID: 27409515.
      View in: PubMed
    4. Newberry RW, Raines RT. 4-Fluoroprolines: Conformational Analysis and Effects on the Stability and Folding of Peptides and Proteins. Top Heterocycl Chem. 2017; 48:1-25. PMID: 28690684.
      View in: PubMed
    5. Newberry RW, Raines RT. Crystal structure of N-(3-oxo-butano-yl)-l-homoserine lactone. Acta Crystallogr E Crystallogr Commun. 2016 Feb 01; 72(Pt 2):136-9. PMID: 26958372; PMCID: PMC4770979.
      View in: PubMed, PubMed Central
    6. Newberry RW, VanVeller B, Raines RT. Thioamides in the collagen triple helix. Chem Commun (Camb). 2015 Jun 14; 51(47):9624-7. PMID: 25967743; PMCID: PMC4449287.
      View in: PubMed, PubMed Central
    7. Choudhary A, Newberry RW, Raines RT. n?p* interactions engender chirality in carbonyl groups. Org Lett. 2014 Jul 03; 16(13):3421-3. PMID: 24926562; PMCID: PMC4096190.
      View in: PubMed, PubMed Central
    8. Newberry RW, Bartlett GJ, VanVeller B, Woolfson DN, Raines RT. Signatures of n?p* interactions in proteins. Protein Sci. 2014 Mar; 23(3):284-8. PMID: 24375625; PMCID: PMC3945836.
      View in: PubMed, PubMed Central
    9. Newberry RW, Raines RT. A key n?p* Interaction in N-acyl homoserine lactones. ACS Chem Biol. 2014 Apr 18; 9(4):880-3. PMID: 24556113; PMCID: PMC4219647.
      View in: PubMed, PubMed Central
    10. Bartlett GJ, Newberry RW, VanVeller B, Raines RT, Woolfson DN. Interplay of hydrogen bonds and n?p* interactions in proteins. J Am Chem Soc. 2013 Dec 11; 135(49):18682-8. PMID: 24256417; PMCID: PMC3940535.
      View in: PubMed, PubMed Central
    11. Newberry RW, Raines RT. n?p* interactions in poly(lactic acid) suggest a role in protein folding. Chem Commun (Camb). 2013 Sep 11; 49(70):7699-701. PMID: 23897514; PMCID: PMC3839959.
      View in: PubMed, PubMed Central
    12. Newberry RW, VanVeller B, Guzei IA, Raines RT. n?p* interactions of amides and thioamides: implications for protein stability. J Am Chem Soc. 2013 May 29; 135(21):7843-6. PMID: 23663100.
      View in: PubMed
    13. Ragain CM, Newberry RW, Ritchie AW, Webb LJ. Role of electrostatics in differential binding of RalGDS to Rap mutations E30D and K31E investigated by vibrational spectroscopy of thiocyanate probes. J Phys Chem B. 2012 Aug 09; 116(31):9326-36. PMID: 22738401.
      View in: PubMed
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