 Robert Newberry, PhD
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| Title(s) | Postdoctoral Scholar, Pharmaceutical Chemistry |
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| School | School of Pharmacy |
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| Address | 555 Mission Bay Blvd South
San Francisco CA 94158
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| Phone | -- |
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ORCID
.gif) | 0000-0002-2020-2641  |
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| vCard | Download vCard |
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 Biography | University of Wisconsin-Madison | PhD | 2016 | Chemistry | | The University of Texas at Austin | BS | 2011 | Biochemistry | | The University of Texas at Austin | BA | 2011 | Liberal Arts |
| University of California, San Francisco | 2020
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| 2025 | NIH Pathway to Independence Award | | University of California, San Francisco | 2016
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| 2017 | NIH Institutional Research Service Award | | University of Wisconsin-Madison | 2014
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| 2015 | ACS Division of Organic Chemistry Graduate Fellowship | | University of Wisconsin-Madison | 2012
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| 2014 | NIH Biotechnology Training Program Fellowship |
Overview I am broadly interested in how the intrinsic, chemical properties and features of proteins bias them toward specific structures, particularly the amyloid state implicated in many neurodegenerative disorders. My work integrates approaches and perspectives from the fields of biophysics and chemical biology to dissect the determinants of folding and misfolding in proteins linked to human diseases like Alzheimer's or Parkinson's. Understanding what makes proteins susceptible or resistant to misfolding will inform strategies for targeted intervention.
Research ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Robust Sequence Determinants of a-Synuclein Toxicity in Yeast Implicate Membrane Binding. ACS Chem Biol. 2020 08 21; 15(8):2137-2153.
Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M. PMID: 32786289.
View in: PubMed Mentions: Fields:
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Deep mutational scanning reveals the structural basis for a-synuclein activity. Nat Chem Biol. 2020 06; 16(6):653-659.
Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF. PMID: 32152544.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Secondary Forces in Protein Folding. ACS Chem Biol. 2019 08 16; 14(8):1677-1686.
Newberry RW, Raines RT. PMID: 31243961.
View in: PubMed Mentions: 1 Fields: Translation: Cells
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The n→π* Interaction. Acc Chem Res. 2017 08 15; 50(8):1838-1846.
Newberry RW, Raines RT. PMID: 28735540.
View in: PubMed Mentions: 13 Fields: Translation: Cells
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A prevalent intraresidue hydrogen bond stabilizes proteins. Nat Chem Biol. 2016 Dec; 12(12):1084-1088.
Newberry RW, Raines RT. PMID: 27748749.
View in: PubMed Mentions: 12 Fields: Translation: Cells
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n→π* Interactions Are Competitive with Hydrogen Bonds. Org Lett. 2016 08 05; 18(15):3614-7.
Newberry RW, Orke SJ, Raines RT. PMID: 27409515.
View in: PubMed Mentions: 5 Fields: Translation: Cells
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4-Fluoroprolines: Conformational Analysis and Effects on the Stability and Folding of Peptides and Proteins. Top Heterocycl Chem. 2017; 48:1-25.
Newberry RW, Raines RT. PMID: 28690684.
View in: PubMed Mentions:
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Crystal structure of N-(3-oxo-butano-yl)-l-homoserine lactone. Acta Crystallogr E Crystallogr Commun. 2016 Feb 01; 72(Pt 2):136-9.
Newberry RW, Raines RT. PMID: 26958372.
View in: PubMed Mentions:
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Thioamides in the collagen triple helix. Chem Commun (Camb). 2015 Jun 14; 51(47):9624-7.
Newberry RW, VanVeller B, Raines RT. PMID: 25967743.
View in: PubMed Mentions: 8 Fields: Translation: Cells
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n→π* interactions engender chirality in carbonyl groups. Org Lett. 2014 Jul 03; 16(13):3421-3.
Choudhary A, Newberry RW, Raines RT. PMID: 24926562.
View in: PubMed Mentions: 12 Fields: Translation: Cells
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Signatures of n→π* interactions in proteins. Protein Sci. 2014 Mar; 23(3):284-8.
Newberry RW, Bartlett GJ, VanVeller B, Woolfson DN, Raines RT. PMID: 24375625.
View in: PubMed Mentions: 16 Fields: Translation: Cells
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A key n→π* Interaction in N-acyl homoserine lactones. ACS Chem Biol. 2014 Apr 18; 9(4):880-3.
Newberry RW, Raines RT. PMID: 24556113.
View in: PubMed Mentions: 10 Fields: Translation: Cells
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Interplay of hydrogen bonds and n→π* interactions in proteins. J Am Chem Soc. 2013 Dec 11; 135(49):18682-8.
Bartlett GJ, Newberry RW, VanVeller B, Raines RT, Woolfson DN. PMID: 24256417.
View in: PubMed Mentions: 19 Fields: Translation: Cells
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n→π* interactions in poly(lactic acid) suggest a role in protein folding. Chem Commun (Camb). 2013 Sep 11; 49(70):7699-701.
Newberry RW, Raines RT. PMID: 23897514.
View in: PubMed Mentions: 8 Fields: Translation: Cells
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n→π* interactions of amides and thioamides: implications for protein stability. J Am Chem Soc. 2013 May 29; 135(21):7843-6.
Newberry RW, VanVeller B, Guzei IA, Raines RT. PMID: 23663100.
View in: PubMed Mentions: 26 Fields:
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Role of electrostatics in differential binding of RalGDS to Rap mutations E30D and K31E investigated by vibrational spectroscopy of thiocyanate probes. J Phys Chem B. 2012 Aug 09; 116(31):9326-36.
Ragain CM, Newberry RW, Ritchie AW, Webb LJ. PMID: 22738401.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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| Year | Publications |
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| 2012 | 1 | | 2013 | 3 | | 2014 | 3 | | 2015 | 1 | | 2016 | 4 | | 2017 | 1 | | 2019 | 1 | | 2020 | 2 |
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This graph shows the number and percent of publications by field.
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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