Robert Newberry • UCSF Profiles

Robert Newberry, PhD

Title(s)	Postdoctoral Scholar, Pharmaceutical Chemistry
School	School of Pharmacy
Address	555 Mission Bay Blvd South San Francisco CA 94158
Phone	--
ORCID	0000-0002-2020-2641
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Biography

Education and Training

University of Wisconsin-Madison	PhD	2016	Chemistry
The University of Texas at Austin	BS	2011	Biochemistry
The University of Texas at Austin	BA	2011	Liberal Arts

Awards and Honors

University of California, San Francisco	2020 -	2025	NIH Pathway to Independence Award
University of California, San Francisco	2016 -	2017	NIH Institutional Research Service Award
University of Wisconsin-Madison	2014 -	2015	ACS Division of Organic Chemistry Graduate Fellowship
University of Wisconsin-Madison	2012 -	2014	NIH Biotechnology Training Program Fellowship

Overview

I am broadly interested in how the intrinsic, chemical properties and features of proteins bias them toward specific structures, particularly the amyloid state implicated in many neurodegenerative disorders. My work integrates approaches and perspectives from the fields of biophysics and chemical biology to dissect the determinants of folding and misfolding in proteins linked to human diseases like Alzheimer's or Parkinson's. Understanding what makes proteins susceptible or resistant to misfolding will inform strategies for targeted intervention.

Websites

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In The News

	Unusual hydrogen bond plays a bigger role in proteins than chemists realized (10/19/2016)
	Overlooked hydrogen bond at the heart of protein structure (10/17/2016)

Research

Research Activities and Funding

Biophysical Determinants of Physiological and Pathological alpha-Synuclein Membrane Interactions
NIH/NINDS K99 NS116679Dec 15, 2020 - Nov 30, 2025
Role: Principal Investigator

Chemical Genetics Technology for Probing Protein Misfolding
Program for Breakthrough Biomedical Research Jul 1, 2018 - Sep 30, 2019
Role: Principal Investigator

ORNG Applications

Featured Publications

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides. Faraday Discuss. 2021 Oct 25. Kratochvil HT, Newberry RW, Mensa B, Mravic M, DeGrado WF. PMID: 34693965.

View in: PubMed Mentions:
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding. ACS Chem Biol. 2020 08 21; 15(8):2137-2153. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M. PMID: 32786289.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Animals Cells
Deep mutational scanning reveals the structural basis for α-synuclein activity. Nat Chem Biol. 2020 06; 16(6):653-659. Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF. PMID: 32152544.

View in: PubMed Mentions: 9 Fields:
Bio Biology Che Chemistry
Translation:Animals Cells
Secondary Forces in Protein Folding. ACS Chem Biol. 2019 08 16; 14(8):1677-1686. Newberry RW, Raines RT. PMID: 31243961; PMCID: PMC6995338.

View in: PubMed Mentions: 14 Fields:
Bio Biochemistry Bio Biology
Translation:Cells
The n→π* Interaction. Acc Chem Res. 2017 08 15; 50(8):1838-1846. Newberry RW, Raines RT. PMID: 28735540.

View in: PubMed Mentions: 28 Fields:
Che Chemistry
Translation:Cells
A prevalent intraresidue hydrogen bond stabilizes proteins. Nat Chem Biol. 2016 Dec; 12(12):1084-1088. Newberry RW, Raines RT. PMID: 27748749; PMCID: PMC5110370.

View in: PubMed Mentions: 19 Fields:
Bio Biology Che Chemistry
Translation:Cells
n→π* Interactions Are Competitive with Hydrogen Bonds. Org Lett. 2016 08 05; 18(15):3614-7. Newberry RW, Orke SJ, Raines RT, Newberry RW, Orke SJ, Raines RT. PMID: 27409515; PMCID: PMC5089869.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry
Translation:Cells
4-Fluoroprolines: Conformational Analysis and Effects on the Stability and Folding of Peptides and Proteins. Top Heterocycl Chem. 2017; 48:1-25. Newberry RW, Raines RT. PMID: 28690684.

View in: PubMed Mentions: 8
Crystal structure of N-(3-oxo-butano-yl)-l-homoserine lactone. Acta Crystallogr E Crystallogr Commun. 2016 Feb 01; 72(Pt 2):136-9. Newberry RW, Raines RT, Newberry RW, Raines RT. PMID: 26958372; PMCID: PMC4770979.

View in: PubMed Mentions: 3
Thioamides in the collagen triple helix. Chem Commun (Camb). 2015 Jun 14; 51(47):9624-7. Newberry RW, VanVeller B, Raines RT, Newberry RW, VanVeller B, Raines RT. PMID: 25967743; PMCID: PMC4449287.

View in: PubMed Mentions: 9 Fields:
Che Chemistry
Translation:Cells
n→π* interactions engender chirality in carbonyl groups. Org Lett. 2014 Jul 03; 16(13):3421-3. Choudhary A, Newberry RW, Raines RT, Choudhary A, Newberry RW, Raines RT. PMID: 24926562; PMCID: PMC4096190.

View in: PubMed Mentions: 13 Fields:
Bio Biochemistry
Translation:Cells
Signatures of n→π* interactions in proteins. Protein Sci. 2014 Mar; 23(3):284-8. Newberry RW, Bartlett GJ, VanVeller B, Woolfson DN, Raines RT, Newberry RW, Bartlett GJ, VanVeller B, Woolfson DN, Raines RT. PMID: 24375625; PMCID: PMC3945836.

View in: PubMed Mentions: 19 Fields:
Bio Biochemistry
Translation:Cells
A key n→π* Interaction in N-acyl homoserine lactones. ACS Chem Biol. 2014 Apr 18; 9(4):880-3. Newberry RW, Raines RT, Newberry RW, Raines RT. PMID: 24556113; PMCID: PMC4219647.

View in: PubMed Mentions: 10 Fields:
Bio Biochemistry Bio Biology
Translation:Cells
Interplay of hydrogen bonds and n→π* interactions in proteins. J Am Chem Soc. 2013 Dec 11; 135(49):18682-8. Bartlett GJ, Newberry RW, VanVeller B, Raines RT, Woolfson DN, Bartlett GJ, Newberry RW, VanVeller B, Raines RT, Woolfson DN. PMID: 24256417; PMCID: PMC3940535.

View in: PubMed Mentions: 23 Fields:
Che Chemistry
Translation:Cells
n→π* interactions in poly(lactic acid) suggest a role in protein folding. Chem Commun (Camb). 2013 Sep 11; 49(70):7699-701. Newberry RW, Raines RT, Newberry RW, Raines RT. PMID: 23897514; PMCID: PMC3839959.

View in: PubMed Mentions: 8 Fields:
Che Chemistry
Translation:Cells
n→π* interactions of amides and thioamides: implications for protein stability. J Am Chem Soc. 2013 May 29; 135(21):7843-6. Newberry RW, VanVeller B, Guzei IA, Raines RT, Newberry RW, VanVeller B, Guzei IA, Raines RT. PMID: 23663100; PMCID: PMC3742804.

View in: PubMed Mentions: 36 Fields:
Che Chemistry
Role of electrostatics in differential binding of RalGDS to Rap mutations E30D and K31E investigated by vibrational spectroscopy of thiocyanate probes. J Phys Chem B. 2012 Aug 09; 116(31):9326-36. Ragain CM, Newberry RW, Ritchie AW, Webb LJ, Ragain CM, Newberry RW, Ritchie AW, Webb LJ. PMID: 22738401.

View in: PubMed Mentions: 3 Fields:
Che Chemistry
Translation:Humans Cells