Robert Newberry, PhD
Biography University of Wisconsin-Madison | PhD | 2016 | Chemistry | The University of Texas at Austin | BS | 2011 | Biochemistry | The University of Texas at Austin | BA | 2011 | Liberal Arts |
University of California, San Francisco | 2016
-
| 2017 | Institutional Research Service Award | University of Wisconsin-Madison | 2014
-
| 2015 | Division of Organic Chemistry Graduate Fellowship, American Chemical Society | University of Wisconsin-Madison | 2012
-
| 2014 | Biotechnology Training Program Fellowship |
Overview I am broadly interested in how the intrinsic, chemical properties and features of proteins bias them toward specific structures, particularly the amyloid state implicated in many neurodegenerative disorders. My work integrates approaches and perspectives from the fields of biophysics and chemical biology to dissect the determinants of folding and misfolding in proteins linked to human diseases like Alzheimer's or Parkinson's. Understanding what makes proteins susceptible or resistant to misfolding will inform strategies for targeted intervention.
Research ORNG Applications Bibliographic
-
Newberry RW, Raines RT. Secondary Forces in Protein Folding. ACS Chem Biol. 2019 Aug 16; 14(8):1677-1686. PMID: 31243961.
-
Newberry RW, Raines RT. The n?p* Interaction. Acc Chem Res. 2017 08 15; 50(8):1838-1846. PMID: 28735540.
-
Newberry RW, Raines RT. A prevalent intraresidue hydrogen bond stabilizes proteins. Nat Chem Biol. 2016 Dec; 12(12):1084-1088. PMID: 27748749.
-
Newberry RW, Orke SJ, Raines RT. n?p* Interactions Are Competitive with Hydrogen Bonds. Org Lett. 2016 08 05; 18(15):3614-7. PMID: 27409515.
-
Newberry RW, Raines RT. 4-Fluoroprolines: Conformational Analysis and Effects on the Stability and Folding of Peptides and Proteins. Top Heterocycl Chem. 2017; 48:1-25. PMID: 28690684.
-
Newberry RW, Raines RT. Crystal structure of N-(3-oxo-butano-yl)-l-homoserine lactone. Acta Crystallogr E Crystallogr Commun. 2016 Feb 01; 72(Pt 2):136-9. PMID: 26958372.
-
Newberry RW, VanVeller B, Raines RT. Thioamides in the collagen triple helix. Chem Commun (Camb). 2015 Jun 14; 51(47):9624-7. PMID: 25967743.
-
Choudhary A, Newberry RW, Raines RT. n?p* interactions engender chirality in carbonyl groups. Org Lett. 2014 Jul 03; 16(13):3421-3. PMID: 24926562.
-
Newberry RW, Bartlett GJ, VanVeller B, Woolfson DN, Raines RT. Signatures of n?p* interactions in proteins. Protein Sci. 2014 Mar; 23(3):284-8. PMID: 24375625.
-
Newberry RW, Raines RT. A key n?p* Interaction in N-acyl homoserine lactones. ACS Chem Biol. 2014 Apr 18; 9(4):880-3. PMID: 24556113.
-
Bartlett GJ, Newberry RW, VanVeller B, Raines RT, Woolfson DN. Interplay of hydrogen bonds and n?p* interactions in proteins. J Am Chem Soc. 2013 Dec 11; 135(49):18682-8. PMID: 24256417.
-
Newberry RW, Raines RT. n?p* interactions in poly(lactic acid) suggest a role in protein folding. Chem Commun (Camb). 2013 Sep 11; 49(70):7699-701. PMID: 23897514.
-
Newberry RW, VanVeller B, Guzei IA, Raines RT. n?p* interactions of amides and thioamides: implications for protein stability. J Am Chem Soc. 2013 May 29; 135(21):7843-6. PMID: 23663100.
-
Ragain CM, Newberry RW, Ritchie AW, Webb LJ. Role of electrostatics in differential binding of RalGDS to Rap mutations E30D and K31E investigated by vibrational spectroscopy of thiocyanate probes. J Phys Chem B. 2012 Aug 09; 116(31):9326-36. PMID: 22738401.
|
Concepts Derived automatically from this person's publications. _
Similar People People who share similar concepts with this person. _
|