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Robert Owen, MD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-750-2101
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency Gastroenterology

    Collapse Overview 
    Collapse Overview
    Career Narrative
    My clinical work includes gastroenterology, general internal medicine, intestinal infectious diseases, HIV infection and AIDS, travel medicine and medical effects of military occupational environmental exposures, especially in Persian Gulf, Afghanistan, Vietnam (Agent Orange) and Ionizing Radiation exposed veterans. I am also a Compensation & Pension examiner for the Department of Veterans Affairs.

    Research Interests:
    My work has involved delineation of the structure and function of Peyer's patches and other mucosal
    lymphoid organs, using ultrastructure, immunohistology, morphometric analysis, and FACS analysis in
    immunocompetent and immunodeficient animal models. Clinical research interests include diarrhea and
    intestinal infections, identifying the role of opportunistic pathogens including Giardia, Cryptosporidia,
    Microsporidia and Mycobacterium avium.


    Collapse Research 
    Collapse Research Activities and Funding
    CELL UPTAKE/CYTOARCHITECTURE IN PEYERS PATCHES
    NIH/NIDDK R01DK038550May 1, 1987 - Jun 30, 1996
    Role: Co-Principal Investigator
    INTESTINAL IMMUNE RESPONSE: REGULATION AND MECHANISMS
    NIH P01AM033004Dec 1, 1983 - Nov 30, 1986
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wang QP, Wu ZD, Wei J, Owen RL, Lun ZR. Human Angiostrongylus cantonensis: an update. Eur J Clin Microbiol Infect Dis. 2012 Apr; 31(4):389-95. PMID: 21725905.
      View in: PubMed
    2. Fujimura Y, Haruma K, Owen RL. Bombesin prevents the atrophy of Peyer's patches and the dysfunction of M cells in rabbits receiving long-term parenteral nutrition. JPEN J Parenter Enteral Nutr. 2007 Mar-Apr; 31(2):75-85. PMID: 17308247.
      View in: PubMed
    3. Schmucker DL, Owen RL, Outenreath R, Thoreux K. Basis for the age-related decline in intestinal mucosal immunity. Clin Dev Immunol. 2003 Jun-Dec; 10(2-4):167-72. PMID: 14768948; PMCID: PMC2485420.
    4. Fujimura Y, Owen RL. Tacrolimus (FK506) and cyclosporine reduce the uptake and transport of particles into rabbit Peyer's patches. Transplantation. 2002 Apr 15; 73(7):1049-54. PMID: 11965030.
      View in: PubMed
    5. Schmucker DL, Thoreux K, Owen RL. Aging impairs intestinal immunity. Mech Ageing Dev. 2001 Sep 15; 122(13):1397-411. PMID: 11470129.
      View in: PubMed
    6. Thoreux K, Owen RL, Schmucker DL. Intestinal lymphocyte number, migration and antibody secretion in young and old rats. Immunology. 2000 Sep; 101(1):161-7. PMID: 11012768; PMCID: PMC2327049.
    7. Owen RL. Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches--a personal and historical perspective. Semin Immunol. 1999 Jun; 11(3):157-63. PMID: 10381861.
      View in: PubMed
    8. Koch J, Owen RL. Small intestine pathogens in AIDS: conventional and opportunistic. Gastrointest Endosc Clin N Am. 1998 Oct; 8(4):869-88. PMID: 9730937.
      View in: PubMed
    9. Owen RL. New perspectives on the pathogenesis of Cryptosporidium biliary disease. Hepatology. 1998 Oct; 28(4):1159-60. PMID: 9755257.
      View in: PubMed
    10. Lüthen R, Owen RL, Sarbia M, Grendell JH, Niederau C. Premature trypsinogen activation during cerulein pancreatitis in rats occurs inside pancreatic acinar cells. Pancreas. 1998 Jul; 17(1):38-43. PMID: 9667518.
      View in: PubMed
    11. Owen RL. M cells as portals of entry for HIV. Pathobiology. 1998; 66(3-4):141-4. PMID: 9693315.
      View in: PubMed
    12. Owen RL. Mid-life crisis for M cells. Gut. 1998 Jan; 42(1):11-2. PMID: 9505877; PMCID: PMC1726977.
    13. Schmidt W, Schneider T, Heise W, Schulzke JD, Weinke T, Ignatius R, Owen RL, Zeitz M, Riecken EO, Ullrich R. Mucosal abnormalities in microsporidiosis. AIDS. 1997 Nov; 11(13):1589-94. PMID: 9365763.
      View in: PubMed
    14. Owen RL. Polymerase chain reaction of stool: a powerful tool for specific diagnosis and epidemiologic investigation of enteric microsporidia infections. AIDS. 1997 May; 11(6):817-8. PMID: 9143615.
      View in: PubMed
    15. Davis IC, Owen RL. The immunopathology of M cells. Springer Semin Immunopathol. 1997; 18(4):421-48. PMID: 9144863.
      View in: PubMed
    16. Schmucker DL, Heyworth MF, Owen RL, Daniels CK. Impact of aging on gastrointestinal mucosal immunity. Dig Dis Sci. 1996 Jun; 41(6):1183-93. PMID: 8654151.
      View in: PubMed
    17. Fujimura Y, Owen RL. M cells as portals of infection: clinical and pathophysiological aspects. Infect Agents Dis. 1996 Jun; 5(3):144-56. PMID: 8805077.
      View in: PubMed
    18. Ichikawa S, Sreedharan SP, Owen RL, Goetzl EJ. Immunochemical localization of type I VIP receptor and NK-1-type substance P receptor in rat lung. Am J Physiol. 1995 Apr; 268(4 Pt 1):L584-8. PMID: 7537460.
      View in: PubMed
    19. Ichikawa S, Sreedharan SP, Goetzl EJ, Owen RL. Immunohistochemical localization of peptidergic nerve fibers and neuropeptide receptors in Peyer's patches of the cat ileum. Regul Pept. 1994 Dec 15; 54(2-3):385-95. PMID: 7536334.
      View in: PubMed
    20. Weber R, Bryan RT, Schwartz DA, Owen RL. Human microsporidial infections. Clin Microbiol Rev. 1994 Oct; 7(4):426-61. PMID: 7834600.
      View in: PubMed
    21. Sandfort J, Hannemann A, Gelderblom H, Stark K, Owen RL, Ruf B. Enterocytozoon bieneusi infection in an immunocompetent patient who had acute diarrhea and who was not infected with the human immunodeficiency virus. Clin Infect Dis. 1994 Sep; 19(3):514-6. PMID: 7811871.
      View in: PubMed
    22. Owen RL. Microsporidia cause human disease: evidence by subtraction. AIDS. 1994 Aug; 8(8):1183. PMID: 7986419.
      View in: PubMed
    23. Owen RL. M cells--entryways of opportunity for enteropathogens. J Exp Med. 1994 Jul 01; 180(1):7-9. PMID: 8006602; PMCID: PMC2191581.
    24. Chui DW, Owen RL. AIDS and the gut. J Gastroenterol Hepatol. 1994 May-Jun; 9(3):291-303. PMID: 8054532.
      View in: PubMed
    25. Kato T, Owen RL. Absence of EGF receptors and of EGF uptake in Peyer's patch dome epithelium. Adv Exp Med Biol. 1994; 355:295-301. PMID: 7709839.
      View in: PubMed
    26. Ohtsuka A, Piazza AJ, Ermak TH, Owen RL. Correlation of extracellular matrix components with the cytoarchitecture of mouse Peyer's patches. Cell Tissue Res. 1992 Sep; 269(3):403-10. PMID: 1423508.
      View in: PubMed
    27. Weber R, Bryan RT, Owen RL, Wilcox CM, Gorelkin L, Visvesvara GS. Improved light-microscopical detection of microsporidia spores in stool and duodenal aspirates. The Enteric Opportunistic Infections Working Group. N Engl J Med. 1992 Jan 16; 326(3):161-6. PMID: 1370122.
      View in: PubMed
    28. Bryan RT, Cali A, Owen RL, Spencer HC. Microsporidia: opportunistic pathogens in patients with AIDS. Prog Clin Parasitol. 1991; 2:1-26. PMID: 1893116.
      View in: PubMed
    29. Owen RL, Piazza AJ, Ermak TH. Ultrastructural and cytoarchitectural features of lymphoreticular organs in the colon and rectum of adult BALB/c mice. Am J Anat. 1991 Jan; 190(1):10-8. PMID: 1984672.
      View in: PubMed
    30. Cali A, Owen RL. Intracellular development of Enterocytozoon, a unique microsporidian found in the intestine of AIDS patients. J Protozool. 1990 Mar-Apr; 37(2):145-55. PMID: 2319490.
      View in: PubMed
    31. Walker RI, Owen RL. Intestinal barriers to bacteria and their toxins. Annu Rev Med. 1990; 41:393-400. PMID: 2184739.
      View in: PubMed
    32. Owen RL, Ermak TH. Structural specializations for antigen uptake and processing in the digestive tract. Springer Semin Immunopathol. 1990; 12(2-3):139-52. PMID: 2205936.
      View in: PubMed
    33. Ermak TH, Steger HJ, Strober S, Owen RL. M cells and granular mononuclear cells in Peyer's patch domes of mice depleted of their lymphocytes by total lymphoid irradiation. Am J Pathol. 1989 Mar; 134(3):529-37. PMID: 2923183; PMCID: PMC1879537.
    34. Ermak TH, Steger HJ, Owen RL, Strober S. Depletion and repopulation of lymphocytes in Peyer's patches of mice after total lymphoid irradiation. Lab Invest. 1988 Nov; 59(5):591-7. PMID: 2903270.
      View in: PubMed
    35. Pappo J, Owen RL. Absence of secretory component expression by epithelial cells overlying rabbit gut-associated lymphoid tissue. Gastroenterology. 1988 Nov; 95(5):1173-7. PMID: 2458985.
      View in: PubMed
    36. Pappo J, Steger HJ, Owen RL. Differential adherence of epithelium overlying gut-associated lymphoid tissue. An ultrastructural study. Lab Invest. 1988 Jun; 58(6):692-7. PMID: 3379916.
      View in: PubMed
    37. Ermak TH, Steger HJ, Owen RL, Heyworth MF. Modulation of lymphocyte subsets in Peyer's patches of mice treated with monoclonal antibody against helper T-cells. J Histochem Cytochem. 1988 Apr; 36(4):417-23. PMID: 2964470.
      View in: PubMed
    38. Owen RL, Cray WC, Ermak TH, Pierce NF. Bacterial characteristics and follicle surface structure: their roles in Peyer's patch uptake and transport of Vibrio cholerae. Adv Exp Med Biol. 1988; 237:705-15. PMID: 3254071.
      View in: PubMed
    39. Ermak TH, Owen RL. Phenotype and distribution of T lymphocytes in Peyer's patches of athymic mice. Histochemistry. 1987; 87(4):321-5. PMID: 3319975.
      View in: PubMed
    40. Owen RL, Jones AL. Epithelial cell specialization within human Peyer's patches: an ultrastructural study of intestinal lymphoid follicles. Gastroenterology. 1974 Feb; 66(2):189-203. PMID: 4810912.
      View in: PubMed
    41. Owen RL, Hill JL. Rectal and pharyngeal gonorrhea in homosexual men. JAMA. 1972 Jun 05; 220(10):1315-8. PMID: 4623385.
      View in: PubMed
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