Robert Owen, MD

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
AddressLocation Required, #Suite 40
Varies CA 00000
Phone415-750-2101
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency Gastroenterology
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    Career Narrative
    My clinical work includes gastroenterology, general internal medicine, intestinal infectious diseases, HIV infection and AIDS, travel medicine and medical effects of military occupational environmental exposures, especially in Persian Gulf, Afghanistan, Vietnam (Agent Orange) and Ionizing Radiation exposed veterans. I am also a Compensation & Pension examiner for the Department of Veterans Affairs.

    Research Interests:
    My work has involved delineation of the structure and function of Peyer's patches and other mucosal
    lymphoid organs, using ultrastructure, immunohistology, morphometric analysis, and FACS analysis in
    immunocompetent and immunodeficient animal models. Clinical research interests include diarrhea and
    intestinal infections, identifying the role of opportunistic pathogens including Giardia, Cryptosporidia,
    Microsporidia and Mycobacterium avium.
    Collapse Global Health Equity

    Collapse Research 
    Collapse Research Activities and Funding
    CELL UPTAKE/CYTOARCHITECTURE IN PEYERS PATCHES
    NIH R01DK038550May 1, 1987 - Jun 30, 1996
    Role: Co-Principal Investigator
    INTESTINAL IMMUNE RESPONSE: REGULATION AND MECHANISMS
    NIH P01AM033004Dec 1, 1983 - Nov 30, 1986
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The development of ultra-high field MRI guidance technology for neuronavigation. J Neurosurg. 2022 Mar 25; 1-13. Rusheen AE, Goyal A, Owen RL, Berning EM, Bothun DT, Giblon RE, Blaha CD, Welker KM, Huston J, Bennet KE, Oh Y, Fagan AJ, Lee KH. PMID: 35334465; PMCID: PMC10193481.
      View in: PubMed   Mentions: 2     Fields:    
    2. Effectiveness of Thalamic Ventralis Oralis Anterior and Posterior Nuclei Deep Brain Stimulation for Posttraumatic Dystonia. Mayo Clin Proc Innov Qual Outcomes. 2022 Apr; 6(2):137-142. Owen RL, Grewal SS, Thompson JM, Hassan A, Lee KH, Klassen BT. PMID: 35243206; PMCID: PMC8866047.
      View in: PubMed   Mentions:
    3. MELD-Na > 16 is associated with high peri-procedural and short-term mortality in patients with ruptured hepatocellular carcinoma treated with emergent transarterial embolization. Abdom Radiol (NY). 2022 01; 47(1):416-422. Jundt MC, Owen RL, Thompson SM, Fleming CJ, Stockland AH, Andrews JC. PMID: 34633495.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. Hypoxia-Associated Changes in Striatal Tonic Dopamine Release: Real-Time in vivo Measurements With a Novel Voltammetry Technique. Front Neurosci. 2020; 14:869. Barath AS, Rusheen AE, Rojas Cabrera JM, Price JB, Owen RL, Shin H, Jang DP, Blaha CD, Lee KH, Oh Y. PMID: 32973432; PMCID: PMC7461928.
      View in: PubMed   Mentions: 6  
    5. Human Angiostrongylus cantonensis: an update. Eur J Clin Microbiol Infect Dis. 2012 Apr; 31(4):389-95. Wang QP, Wu ZD, Wei J, Owen RL, Lun ZR. PMID: 21725905.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsPHPublic Health
    6. Bombesin prevents the atrophy of Peyer's patches and the dysfunction of M cells in rabbits receiving long-term parenteral nutrition. JPEN J Parenter Enteral Nutr. 2007 Mar-Apr; 31(2):75-85. Fujimura Y, Haruma K, Owen RL. PMID: 17308247.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    7. Ocular defense mechanisms with special reference to the demonstration and functional morphology of the conjunctiva-associated lymphoid tissue in Japanese monkeys. Arch Histol Cytol. 2006 Dec; 69(5):311-22. Kageyama M, Nakatsuka K, Yamaguchi T, Owen RL, Shimada T. PMID: 17372387.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    8. Basis for the age-related decline in intestinal mucosal immunity. Clin Dev Immunol. 2003 Jun-Dec; 10(2-4):167-72. Schmucker DL, Owen RL, Outenreath R, Thoreux K. PMID: 14768948; PMCID: PMC2485420.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    9. Tacrolimus (FK506) and cyclosporine reduce the uptake and transport of particles into rabbit Peyer's patches. Transplantation. 2002 Apr 15; 73(7):1049-54. Fujimura Y, Owen RL. PMID: 11965030.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Aging impairs intestinal immunity. Mech Ageing Dev. 2001 Sep 15; 122(13):1397-411. Schmucker DL, Thoreux K, Owen RL. PMID: 11470129.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    11. Intestinal lymphocyte number, migration and antibody secretion in young and old rats. Immunology. 2000 Sep; 101(1):161-7. Thoreux K, Owen RL, Schmucker DL. PMID: 11012768; PMCID: PMC2327049.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    12. Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches--a personal and historical perspective. Semin Immunol. 1999 Jun; 11(3):157-63. Owen RL. PMID: 10381861.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    13. Small intestine pathogens in AIDS: conventional and opportunistic. Gastrointest Endosc Clin N Am. 1998 Oct; 8(4):869-88. Koch J, Owen RL. PMID: 9730937; PMCID: PMC7129401.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. New perspectives on the pathogenesis of Cryptosporidium biliary disease. Hepatology. 1998 Oct; 28(4):1159-60. Owen RL. PMID: 9755257.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    15. Premature trypsinogen activation during cerulein pancreatitis in rats occurs inside pancreatic acinar cells. Pancreas. 1998 Jul; 17(1):38-43. Lüthen R, Owen RL, Sarbia M, Grendell JH, Niederau C. PMID: 9667518.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. M cells as portals of entry for HIV. Pathobiology. 1998; 66(3-4):141-4. Owen RL. PMID: 9693315.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Mid-life crisis for M cells. Gut. 1998 Jan; 42(1):11-2. Owen RL. PMID: 9505877; PMCID: PMC1726977.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Mucosal abnormalities in microsporidiosis. AIDS. 1997 Nov; 11(13):1589-94. Schmidt W, Schneider T, Heise W, Schulzke JD, Weinke T, Ignatius R, Owen RL, Zeitz M, Riecken EO, Ullrich R. PMID: 9365763.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Polymerase chain reaction of stool: a powerful tool for specific diagnosis and epidemiologic investigation of enteric microsporidia infections. AIDS. 1997 May; 11(6):817-8. Owen RL. PMID: 9143615.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    20. The immunopathology of M cells. Springer Semin Immunopathol. 1997; 18(4):421-48. Davis IC, Owen RL. PMID: 9144863.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    21. Impact of aging on gastrointestinal mucosal immunity. Dig Dis Sci. 1996 Jun; 41(6):1183-93. Schmucker DL, Heyworth MF, Owen RL, Daniels CK. PMID: 8654151.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    22. M cells as portals of infection: clinical and pathophysiological aspects. Infect Agents Dis. 1996 Jun; 5(3):144-56. Fujimura Y, Owen RL. PMID: 8805077.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    23. Immunochemical localization of type I VIP receptor and NK-1-type substance P receptor in rat lung. Am J Physiol. 1995 Apr; 268(4 Pt 1):L584-8. Ichikawa S, Sreedharan SP, Owen RL, Goetzl EJ. PMID: 7537460.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. Immunohistochemical localization of peptidergic nerve fibers and neuropeptide receptors in Peyer's patches of the cat ileum. Regul Pept. 1994 Dec 15; 54(2-3):385-95. Ichikawa S, Sreedharan SP, Goetzl EJ, Owen RL. PMID: 7536334.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    25. Human microsporidial infections. Clin Microbiol Rev. 1994 Oct; 7(4):426-61. Weber R, Bryan RT, Schwartz DA, Owen RL. PMID: 7834600; PMCID: PMC358336.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimals
    26. Enterocytozoon bieneusi infection in an immunocompetent patient who had acute diarrhea and who was not infected with the human immunodeficiency virus. Clin Infect Dis. 1994 Sep; 19(3):514-6. Sandfort J, Hannemann A, Gelderblom H, Stark K, Owen RL, Ruf B. PMID: 7811871.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    27. Microsporidia cause human disease: evidence by subtraction. AIDS. 1994 Aug; 8(8):1183. Owen RL. PMID: 7986419.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    28. M cells--entryways of opportunity for enteropathogens. J Exp Med. 1994 Jul 01; 180(1):7-9. Owen RL. PMID: 8006602; PMCID: PMC2191581.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    29. AIDS and the gut. J Gastroenterol Hepatol. 1994 May-Jun; 9(3):291-303. Chui DW, Owen RL. PMID: 8054532.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    30. Absence of EGF receptors and of EGF uptake in Peyer's patch dome epithelium. Adv Exp Med Biol. 1994; 355:295-301. Kato T, Owen RL. PMID: 7709839.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Correlation of extracellular matrix components with the cytoarchitecture of mouse Peyer's patches. Cell Tissue Res. 1992 Sep; 269(3):403-10. Ohtsuka A, Piazza AJ, Ermak TH, Owen RL. PMID: 1423508.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. Improved light-microscopical detection of microsporidia spores in stool and duodenal aspirates. The Enteric Opportunistic Infections Working Group. N Engl J Med. 1992 Jan 16; 326(3):161-6. Weber R, Bryan RT, Owen RL, Wilcox CM, Gorelkin L, Visvesvara GS. PMID: 1370122.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    33. Microsporidia: opportunistic pathogens in patients with AIDS. Prog Clin Parasitol. 1991; 2:1-26. Bryan RT, Cali A, Owen RL, Spencer HC. PMID: 1893116.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    34. Ultrastructural and cytoarchitectural features of lymphoreticular organs in the colon and rectum of adult BALB/c mice. Am J Anat. 1991 Jan; 190(1):10-8. Owen RL, Piazza AJ, Ermak TH. PMID: 1984672.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    35. Intracellular development of Enterocytozoon, a unique microsporidian found in the intestine of AIDS patients. J Protozool. 1990 Mar-Apr; 37(2):145-55. Cali A, Owen RL. PMID: 2319490.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    36. Intestinal barriers to bacteria and their toxins. Annu Rev Med. 1990; 41:393-400. Walker RI, Owen RL. PMID: 2184739.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    37. Structural specializations for antigen uptake and processing in the digestive tract. Springer Semin Immunopathol. 1990; 12(2-3):139-52. Owen RL, Ermak TH. PMID: 2205936.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    38. M cells and granular mononuclear cells in Peyer's patch domes of mice depleted of their lymphocytes by total lymphoid irradiation. Am J Pathol. 1989 Mar; 134(3):529-37. Ermak TH, Steger HJ, Strober S, Owen RL. PMID: 2923183; PMCID: PMC1879537.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    39. Depletion and repopulation of lymphocytes in Peyer's patches of mice after total lymphoid irradiation. Lab Invest. 1988 Nov; 59(5):591-7. Ermak TH, Steger HJ, Owen RL, Strober S. PMID: 2903270.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    40. Absence of secretory component expression by epithelial cells overlying rabbit gut-associated lymphoid tissue. Gastroenterology. 1988 Nov; 95(5):1173-7. Pappo J, Owen RL. PMID: 2458985.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    41. Differential adherence of epithelium overlying gut-associated lymphoid tissue. An ultrastructural study. Lab Invest. 1988 Jun; 58(6):692-7. Pappo J, Steger HJ, Owen RL. PMID: 3379916.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    42. Modulation of lymphocyte subsets in Peyer's patches of mice treated with monoclonal antibody against helper T-cells. J Histochem Cytochem. 1988 Apr; 36(4):417-23. Ermak TH, Steger HJ, Owen RL, Heyworth MF. PMID: 2964470.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    43. Bacterial characteristics and follicle surface structure: their roles in Peyer's patch uptake and transport of Vibrio cholerae. Adv Exp Med Biol. 1988; 237:705-15. Owen RL, Cray WC, Ermak TH, Pierce NF. PMID: 3254071.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    44. Phenotype and distribution of T lymphocytes in Peyer's patches of athymic mice. Histochemistry. 1987; 87(4):321-5. Ermak TH, Owen RL. PMID: 3319975.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. Epithelial cell specialization within human Peyer's patches: an ultrastructural study of intestinal lymphoid follicles. Gastroenterology. 1974 Feb; 66(2):189-203. Owen RL, Jones AL. PMID: 4810912.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    46. Rectal and pharyngeal gonorrhea in homosexual men. JAMA. 1972 Jun 05; 220(10):1315-8. Owen RL, Hill JL. PMID: 4623385.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
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