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Robert Rosenfield, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPediatrics
Address
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    Collapse Research 
    Collapse Research Activities and Funding
    Pediatric Endocrinology Research Training Grant
    NIH/NIDDK T32DK064582Jul 1, 2003 - Jun 30, 2019
    Role: Co-Principal Investigator
    The Molecular Basis of Ovarian Testosterone Production
    NIH/NICHD R01HD039267Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    PHD PREPARATION FOR PEDIATRIC SCIENCE TRAINEES
    NIH/NICHD T32HD007379Jul 1, 1989 - Jun 30, 1993
    Role: Principal Investigator
    FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    NIH/NICHD R01HD006308Jul 1, 1978 - Jun 30, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Martin KA, Anderson RR, Chang RJ, Ehrmann DA, Lobo RA, Murad MH, Pugeat MM, Rosenfield R. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018 Mar 07. PMID: 29522147.
      View in: PubMed
    2. Klein KO, Rosenfield R, Santen RJ, Gawlik A, Backeljauw P, Gravholt CH, Sas T, Mauras N. Estrogen Replacement in Turner Syndrome: Literature Review and Practical Considerations. J Clin Endocrinol Metab. 2018 Feb 08. PMID: 29438552.
      View in: PubMed
    3. Rosenfield R. Letter to the Editor: "Normal Pubertal Development in Daughters of Women With PCOS: A Controlled Study". J Clin Endocrinol Metab. 2017 Jul 01; 102(7):2560. PMID: 28899075.
      View in: PubMed
    4. Greeley SA, Littlejohn E, Husain AN, Waggoner D, Gundeti M, Rosenfield R. The Effect of the Testis on the Ovary: Structure-Function Relationships in a Neonate with a Unilateral Ovotestis (Ovotesticular Disorder of Sex Development)?. Horm Res Paediatr. 2017; 87(3):205-212. PMID: 28253506.
      View in: PubMed
    5. Rosenfield R, Ehrmann DA. The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocr Rev. 2016 10; 37(5):467-520. PMID: 27459230.
      View in: PubMed
    6. Rosenfield R. The Diagnosis of Polycystic Ovary Syndrome in Adolescents. Pediatrics. 2015 Dec; 136(6):1154-65. PMID: 26598450.
      View in: PubMed
    7. Witchel SF, Oberfield S, Rosenfield R, Codner E, Bonny A, Ibáñez L, Pena A, Horikawa R, Gomez-Lobo V, Joel D, Tfayli H, Arslanian S, Dabadghao P, Garcia Rudaz C, Lee PA. The Diagnosis of Polycystic Ovary Syndrome during Adolescence. Horm Res Paediatr. 2015 Apr 01. PMID: 25833060.
      View in: PubMed
    8. Rosenfield R, DiMeglio LA, Mauras N, Ross J, Shaw ND, Greeley SA, Haymond M, Rubin K, Rhodes ET. Commentary: Launch of a quality improvement network for evidence-based management of uncommon pediatric endocrine disorders: Turner syndrome as a prototype. J Clin Endocrinol Metab. 2015 Apr; 100(4):1234-6. PMID: 25844763.
      View in: PubMed
    9. Rosenfield R, Ehrmann DA, Littlejohn EE. Adolescent polycystic ovary syndrome due to functional ovarian hyperandrogenism persists into adulthood. J Clin Endocrinol Metab. 2015 Apr; 100(4):1537-43. PMID: 25675386; PMCID: PMC4399308.
    10. Rosenfield R. The Polycystic Ovary Morphology-Polycystic Ovary Syndrome Spectrum. J Pediatr Adolesc Gynecol. 2015 Dec; 28(6):412-9. PMID: 25840648.
      View in: PubMed
    11. Rosenfield R. Clinical review: Adolescent anovulation: maturational mechanisms and implications. J Clin Endocrinol Metab. 2013 Sep; 98(9):3572-83. PMID: 23913942; PMCID: PMC3763969.
    12. Rosenfield R, Bordini B, Yu C. Comparison of detection of normal puberty in girls by a hormonal sleep test and a gonadotropin-releasing hormone agonist test. J Clin Endocrinol Metab. 2013 Apr; 98(4):1591-601. PMID: 23457407; PMCID: PMC3615202.
    13. Rosenfield R, Bordini B, Yu C. Comparison of detection of normal puberty in boys by a hormonal sleep test and a gonadotropin-releasing hormone agonist test. J Clin Endocrinol Metab. 2012 Dec; 97(12):4596-604. PMID: 23043188; PMCID: PMC3513543.
    14. Welt CK, Styrkarsdottir U, Ehrmann DA, Thorleifsson G, Arason G, Gudmundsson JA, Ober C, Rosenfield R, Saxena R, Thorsteinsdottir U, Crowley WF, Stefansson K. Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab. 2012 Jul; 97(7):E1342-7. PMID: 22547425; PMCID: PMC3387396.
    15. Rosenfield R, Wroblewski K, Padmanabhan V, Littlejohn E, Mortensen M, Ehrmann DA. Antimüllerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries. Fertil Steril. 2012 Jul; 98(1):242-9. PMID: 22541936; PMCID: PMC3597099.
    16. Levine RJ, Genel M, Cuttler L, Becker DJ, Nieman L, Rosenfield R. Overcoming burdens in the regulation of clinical research in children. Proceedings of a consensus conference, in historical context. Int J Pediatr Endocrinol. 2011 Dec 30; 2011(1):19. PMID: 22208165; PMCID: PMC3276425.
    17. Rosenfield R, Mortensen M, Wroblewski K, Littlejohn E, Ehrmann DA. Determination of the source of androgen excess in functionally atypical polycystic ovary syndrome by a short dexamethasone androgen-suppression test and a low-dose ACTH test. Hum Reprod. 2011 Nov; 26(11):3138-46. PMID: 21908468; PMCID: PMC3196876.
    18. Gregg B, Kociolek LK, Qin K, Rosenfield R, Yu C. P450c17 deficiency caused by compound heterozygosity for two novel mutations presenting as hypotension in early infancy. Horm Res Paediatr. 2011; 76(6):434-41. PMID: 21822006.
      View in: PubMed
    19. Deplewski D, Qin K, Ciletti N, Rosenfield R. Unique mode of lipogenic activation in rat preputial sebocytes. J Nutr Metab. 2011; 2011:163631. PMID: 21808727; PMCID: PMC3144693.
    20. Bordini B, Rosenfield R. Normal pubertal development: part II: clinical aspects of puberty. Pediatr Rev. 2011 Jul; 32(7):281-92. PMID: 21724902.
      View in: PubMed
    21. Bordini B, Rosenfield R. Normal pubertal development: Part I: The endocrine basis of puberty. Pediatr Rev. 2011 Jun; 32(6):223-9. PMID: 21632873.
      View in: PubMed
    22. Cuttler L, Rosenfield R. Assessing the value of treatments to increase height. N Engl J Med. 2011 Mar 31; 364(13):1274-6. PMID: 21449792.
      View in: PubMed
    23. Qin K, Rosenfield R. Mutations of the hexose-6-phosphate dehydrogenase gene rarely cause hyperandrogenemic polycystic ovary syndrome. Steroids. 2011 Jan; 76(1-2):135-9. PMID: 21050867; PMCID: PMC3023921.
    24. Rosenfield R, Bordini B. Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity. Brain Res. 2010 Dec 10; 1364:186-97. PMID: 20816944; PMCID: PMC2992573.
    25. Bordini B, Littlejohn E, Rosenfield R. LH Dynamics in Overweight Girls with Premature Adrenarche and Slowly Progressive Sexual Precocity. Int J Pediatr Endocrinol. 2010; 2010. PMID: 20886012; PMCID: PMC2945655.
    26. Zimmer CA, Ehrmann DA, Rosenfield R. Potential diagnostic utility of intermittent administration of short-acting gonadotropin-releasing hormone agonist in gonadotropin deficiency. Fertil Steril. 2010 Dec; 94(7):2697-702. PMID: 20553679; PMCID: PMC2944005.
    27. Du X, Rosenfield R, Qin K. KLF15 Is a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulation of testosterone production and fat stores in women. J Clin Endocrinol Metab. 2009 Jul; 94(7):2594-601. PMID: 19366843; PMCID: PMC2708951.
    28. Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics. 2009 Apr; 123(4):e752-62. PMID: 19332438.
      View in: PubMed
    29. Hirshfeld-Cytron J, Barnes RB, Ehrmann DA, Caruso A, Mortensen MM, Rosenfield R. Characterization of functionally typical and atypical types of polycystic ovary syndrome. J Clin Endocrinol Metab. 2009 May; 94(5):1587-94. PMID: 19240152; PMCID: PMC2684483.
    30. Mortensen M, Ehrmann DA, Littlejohn E, Rosenfield R. Asymptomatic volunteers with a polycystic ovary are a functionally distinct but heterogeneous population. J Clin Endocrinol Metab. 2009 May; 94(5):1579-86. PMID: 19240158; PMCID: PMC2684482.
    31. Bordini B, Littlejohn E, Rosenfield R. Blunted sleep-related luteinizing hormone rise in healthy premenarcheal pubertal girls with elevated body mass index. J Clin Endocrinol Metab. 2009 Apr; 94(4):1168-75. PMID: 19190110; PMCID: PMC2682481.
    32. Rosenfield R, Lipton RB, Drum ML. Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index. Pediatrics. 2009 Jan; 123(1):84-8. PMID: 19117864.
      View in: PubMed
    33. Rosenfield R. What every physician should know about polycystic ovary syndrome. Dermatol Ther. 2008 Sep-Oct; 21(5):354-61. PMID: 18844713.
      View in: PubMed
    34. Rosenfield R. Perspectives on the endocrine society clinical practice guideline for the evaluation and treatment of women with hirsutism. Endokrynol Pol. 2008 May-Jun; 59(3):254-5. PMID: 18615402.
      View in: PubMed
    35. Martin KA, Chang RJ, Ehrmann DA, Ibanez L, Lobo RA, Rosenfield R, Shapiro J, Montori VM, Swiglo BA. Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008 Apr; 93(4):1105-20. PMID: 18252793.
      View in: PubMed
    36. Nowaczyk MJ, Carter MT, Xu J, Huggins M, Raca G, Das S, Martin CL, Schwartz S, Rosenfield R, Waggoner DJ. Paternal deletion 6q24.3: a new congenital anomaly syndrome associated with intrauterine growth failure, early developmental delay and characteristic facial appearance. Am J Med Genet A. 2008 Feb 01; 146A(3):354-60. PMID: 18203180.
      View in: PubMed
    37. Rosenfield R. Improving balance in regulatory oversight of research in children and adolescents: a clinical investigator's perspective. Ann N Y Acad Sci. 2008; 1135:287-95. PMID: 18574235.
      View in: PubMed
    38. Rosenfield R. Does a primary acceleration of LH pulse frequency underlie an association between central precocious puberty and polycystic ovary syndrome? Commentary on Escobar ME et al: Acceleration of LH pulse frequency in adolescent girls with a history of central precocious puberty with versus without hyperandrogenism (Horm Res 2007;68:278-285). Horm Res. 2007; 68(6):286-7. PMID: 17587858.
      View in: PubMed
    39. Bhagavath B, Xu N, Ozata M, Rosenfield R, Bick DP, Sherins RJ, Layman LC. KAL1 mutations are not a common cause of idiopathic hypogonadotrophic hypogonadism in humans. Mol Hum Reprod. 2007 Mar; 13(3):165-70. PMID: 17213338.
      View in: PubMed
    40. Littlejohn EE, Weiss RE, Deplewski D, Edidin DV, Rosenfield R. Intractable early childhood obesity as the initial sign of insulin resistant hyperinsulinism and precursor of polycystic ovary syndrome. J Pediatr Endocrinol Metab. 2007 Jan; 20(1):41-51. PMID: 17315528.
      View in: PubMed
    41. Rosenfield R. Clinical review: Identifying children at risk for polycystic ovary syndrome. J Clin Endocrinol Metab. 2007 Mar; 92(3):787-96. PMID: 17179197.
      View in: PubMed
    42. Mortensen M, Rosenfield R, Littlejohn E. Functional significance of polycystic-size ovaries in healthy adolescents. J Clin Endocrinol Metab. 2006 Oct; 91(10):3786-90. PMID: 16895960.
      View in: PubMed
    43. Leibel NI, Baumann EE, Kocherginsky M, Rosenfield R. Relationship of adolescent polycystic ovary syndrome to parental metabolic syndrome. J Clin Endocrinol Metab. 2006 Apr; 91(4):1275-83. PMID: 16449341.
      View in: PubMed
    44. Drobac S, Rubin K, Rogol AD, Rosenfield R. A workshop on pubertal hormone replacement options in the United States. J Pediatr Endocrinol Metab. 2006 Jan; 19(1):55-64. PMID: 16509529.
      View in: PubMed
    45. Rosenfield R. Clinical practice. Hirsutism. N Engl J Med. 2005 Dec 15; 353(24):2578-88. PMID: 16354894.
      View in: PubMed
    46. Rosenfield R. Hirsutism and the variable response of the pilosebaceous unit to androgen. J Investig Dermatol Symp Proc. 2005 Dec; 10(3):205-8. PMID: 16382665.
      View in: PubMed
    47. Qin K, Ehrmann DA, Cox N, Refetoff S, Rosenfield R. Identification of a functional polymorphism of the human type 5 17beta-hydroxysteroid dehydrogenase gene associated with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 Jan; 91(1):270-6. PMID: 16263811; PMCID: PMC1522092.
    48. Rosenfield R, Devine N, Hunold JJ, Mauras N, Moshang T, Root AW. Salutary effects of combining early very low-dose systemic estradiol with growth hormone therapy in girls with Turner syndrome. J Clin Endocrinol Metab. 2005 Dec; 90(12):6424-30. PMID: 16189255.
      View in: PubMed
    49. Buggs C, Rosenfield R. Polycystic ovary syndrome in adolescence. Endocrinol Metab Clin North Am. 2005 Sep; 34(3):677-705, x. PMID: 16085166; PMCID: PMC3477606.
    50. Qin K, Rosenfield R. Characterization of the basal promoter element of the human type 5 17beta-hydroxysteroid dehydrogenase gene. Biochim Biophys Acta. 2005 May 01; 1728(3):115-25. PMID: 15814298.
      View in: PubMed
    51. Elsholz DD, Padmanabhan V, Rosenfield R, Olton PR, Phillips DJ, Foster CM. GnRH agonist stimulation of the pituitary-gonadal axis in children: age and sex differences in circulating inhibin-B and activin-A. Hum Reprod. 2004 Dec; 19(12):2748-58. PMID: 15513981.
      View in: PubMed
    52. Rosenfield R, Barnes RB, Ehrmann DA, Toledano AY. The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women. J Clin Endocrinol Metab. 2003 Dec; 88(12):6115; author reply 6115-6. PMID: 14671222.
      View in: PubMed
    53. Sardani Y, Qin K, Haas M, Aronson AJ, Rosenfield R. Bartter syndrome complicated by immune complex nephropathy. Case report and literature review. Pediatr Nephrol. 2003 Sep; 18(9):913-8. PMID: 12836094.
      View in: PubMed
    54. Alonso LC, Rosenfield R. Molecular genetic and endocrine mechanisms of hair growth. Horm Res. 2003; 60(1):1-13. PMID: 12792148.
      View in: PubMed
    55. Rosenfield R. Serum cortisol and 17-hydroxyprogesterone concentrations in children with classic congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2002 Jun; 87(6):2993; author reply 2993. PMID: 12050289.
      View in: PubMed
    56. Alonso LC, Rosenfield R. Oestrogens and puberty. Best Pract Res Clin Endocrinol Metab. 2002 Mar; 16(1):13-30. PMID: 11987895.
      View in: PubMed
    57. Barnes RB, Namnoum AB, Rosenfield R, Layman LC. The role of LH and FSH in ovarian androgen secretion and ovarian follicular development: clinical studies in a patient with isolated FSH deficiency and multicystic ovaries. Hum Reprod. 2002 Jan; 17(1):88-91. PMID: 11756367.
      View in: PubMed
    58. Rosenfield R, Wu PP, Ciletti N. Sebaceous epithelial cell differentiation requires cyclic adenosine monophosphate generation. In Vitro Cell Dev Biol Anim. 2002 Jan; 38(1):54-7. PMID: 11963970.
      View in: PubMed
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