Roberto Zoncu
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Title(s) | Lecturer, Graduate Med Science Unit |
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School | School of Medicine |
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Address | |
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Phone | -- |
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vCard | Download vCard |
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Bibliographic
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.)
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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C. Dev Cell. 2020 Dec 07.
Davis OB, Shin HR, Lim CY, Wu EY, Kukurugya M, Maher CF, Perera RM, Ordonez MP, Zoncu R. PMID: 33308480.
View in: PubMed Mentions: Fields:
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Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD. Nature. 2020 09; 585(7824):251-255.
Su MY, Fromm SA, Zoncu R, Hurley JH. PMID: 32848248.
View in: PubMed Mentions: Fields: Translation: HumansCells
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The Lysosome at the Intersection of Cellular Growth and Destruction. Dev Cell. 2020 Jul 20; 54(2):226-238.
Shin HR, Zoncu R. PMID: 32610045.
View in: PubMed Mentions: 1 Fields:
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Lysosomal recycling of amino acids affects ER quality control. Sci Adv. 2020 Jun; 6(26):eaaz9805.
Higuchi-Sanabria R, Shen K, Kelet N, Frankino PA, Durieux J, Bar-Ziv R, Sing CN, Garcia EJ, Homentcovschi S, Sanchez M, Wu R, Tronnes SU, Joe L, Webster B, Ahilon-Jeronimo A, Monshietehadi S, Dallarda S, Pender C, Pon LA, Zoncu R, Dillin A. PMID: 32637599.
View in: PubMed Mentions: Fields:
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A zinc-sensing protein gives flies a gut feeling for growth. Nature. 2020 04; 580(7802):187-188.
Citron YR, Zoncu R. PMID: 32203359.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease. Sci Rep. 2020 03 11; 10(1):4528.
Bindesbøll C, Aas A, Ogmundsdottir MH, Pankiv S, Reine T, Zoncu R, Simonsen A. PMID: 32161285.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science. 2019 11 22; 366(6468):971-977.
Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R. PMID: 31672913.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019 11; 575(7784):688-692.
Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA. PMID: 31634900.
View in: PubMed Mentions: 77 Fields: Translation: HumansAnimalsCells
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ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Nat Cell Biol. 2019 10; 21(10):1206-1218.
Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R. PMID: 31548609.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimalsCells
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Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 08; 15(8):776-785.
Chung CY, Shin HR, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R, Nomura DK. PMID: 31285595.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Rhomboids Distort Time and Space: Accelerated Proteolysis through Membrane Disruption. Biochemistry. 2019 04 23; 58(16):2093-2094.
Citron YR, Zoncu R. PMID: 30977995.
View in: PubMed Mentions: Fields: Translation: Cells
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The lysosome as a cellular centre for signalling, metabolism and quality control. Nat Cell Biol. 2019 02; 21(2):133-142.
Lawrence RE, Zoncu R. PMID: 30602725.
View in: PubMed Mentions: 81 Fields: Translation: HumansAnimalsCells
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A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold. Nat Cell Biol. 2018 09; 20(9):1052-1063.
Lawrence RE, Cho KF, Rappold R, Thrun A, Tofaute M, Kim DJ, Moldavski O, Hurley JH, Zoncu R. PMID: 30061680.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage. Mol Cell. 2018 04 05; 70(1):5-7.
Shin HR, Zoncu R. PMID: 29625038.
View in: PubMed Mentions: Fields: Translation: Cells
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Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors. Cell Rep. 2017 Nov 21; 21(8):2031-2038.
De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE. PMID: 29166595.
View in: PubMed Mentions: 12 Fields: Translation: Cells
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Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Mol Cell. 2017 Dec 07; 68(5):835-846.e3.
Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH. PMID: 29107538.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov. 2017 11; 7(11):1266-1283.
Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK. PMID: 28899863.
View in: PubMed Mentions: 38 Fields: Translation: HumansAnimalsCells
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Emerging Roles for the Lysosome in Lipid Metabolism. Trends Cell Biol. 2017 11; 27(11):833-850.
Thelen AM, Zoncu R. PMID: 28838620.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Dev Cell. 2017 07 10; 42(1):9-21.e5.
Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. PMID: 28697336.
View in: PubMed Mentions: 54 Fields: Translation: HumansAnimalsCells
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Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science. 2017 06 16; 356(6343):1188-1192.
Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, Di Giovannantonio LG, Nusco E, Platt N, Guida A, Ogmundsdottir MH, Lanfrancone L, Perera RM, Zoncu R, Pelicci PG, Settembre C, Ballabio A. PMID: 28619945.
View in: PubMed Mentions: 40 Fields: Translation: HumansAnimalsCells
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Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science. 2017 03 24; 355(6331):1306-1311.
Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. PMID: 28336668.
View in: PubMed Mentions: 75 Fields: Translation: HumansAnimalsCells
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PhotoGate microscopy to track single molecules in crowded environments. Nat Commun. 2017 01 10; 8:13978.
Belyy V, Shih SM, Bandaria J, Huang Y, Lawrence RE, Zoncu R, Yildiz A. PMID: 28071667.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Dynamics of mTORC1 activation in response to amino acids. Elife. 2016 10 11; 5.
Manifava M, Smith M, Rotondo S, Walker S, Niewczas I, Zoncu R, Clark J, Ktistakis NT. PMID: 27725083.
View in: PubMed Mentions: 23 Fields: Translation: HumansCells
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The lysosome as a command-and-control center for cellular metabolism. J Cell Biol. 2016 09 12; 214(6):653-64.
Lim CY, Zoncu R. PMID: 27621362.
View in: PubMed Mentions: 52 Fields: Translation: HumansAnimalsCells
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The Lysosome as a Regulatory Hub. Annu Rev Cell Dev Biol. 2016 10 06; 32:223-253.
Perera RM, Zoncu R. PMID: 27501449.
View in: PubMed Mentions: 82 Fields: Translation: HumansAnimalsCells
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Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8224-9.
Young LN, Cho K, Lawrence R, Zoncu R, Hurley JH. PMID: 27385829.
View in: PubMed Mentions: 21 Fields: Translation: HumansCells
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Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet. 2016 05 27; 48(6):700.
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J. PMID: 27230687.
View in: PubMed Mentions: 1 Fields:
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Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet. 2016 Feb; 48(2):183-8.
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J. PMID: 26691987.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimalsCells
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Identification of an oncogenic RAB protein. Science. 2015 Oct 09; 350(6257):211-7.
Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL. PMID: 26338797.
View in: PubMed Mentions: 35 Fields: Translation: HumansCells
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Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015 Aug 20; 524(7565):361-5.
Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N. PMID: 26168401.
View in: PubMed Mentions: 183 Fields: Translation: HumansAnimalsCells
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Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science. 2015 Apr 17; 348(6232):340-3.
Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM. PMID: 25837514.
View in: PubMed Mentions: 138 Fields: Translation: HumansCells
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Control of cellular homeostasis: organelles take the pilot's seat. Mol Biol Cell. 2015 Mar 15; 26(6):1009-10.
Tooze S, Zoncu R. PMID: 25767200.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 09; 347(6218):188-94.
Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. PMID: 25567906.
View in: PubMed Mentions: 228 Fields: Translation: HumansCells
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The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21; 52(4):495-505.
Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM. PMID: 24095279.
View in: PubMed Mentions: 175 Fields: Translation: HumansCells
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Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol. 2013 Jul; 31(7):653-8.
Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG. PMID: 23792629.
View in: PubMed Mentions: 143 Fields: Translation: HumansCells
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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature. 2013 Jan 31; 493(7434):679-83.
Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM. PMID: 23263183.
View in: PubMed Mentions: 153 Fields: Translation: Animals
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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 2012 Sep 14; 150(6):1196-208.
Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. PMID: 22980980.
View in: PubMed Mentions: 318 Fields: Translation: HumansAnimalsCells
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Amino acids and mTORC1: from lysosomes to disease. Trends Mol Med. 2012 Sep; 18(9):524-33.
Efeyan A, Zoncu R, Sabatini DM. PMID: 22749019.
View in: PubMed Mentions: 158 Fields: Translation: HumansCells
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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 2012 Mar 07; 31(5):1095-108.
Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A. PMID: 22343943.
View in: PubMed Mentions: 537 Fields: Translation: HumansAnimalsCells
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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science. 2011 Nov 04; 334(6056):678-83.
Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. PMID: 22053050.
View in: PubMed Mentions: 564 Fields: Translation: HumansAnimalsCells
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Cell biology. The TASCC of secretion. Science. 2011 May 20; 332(6032):923-5.
Zoncu R, Sabatini DM. PMID: 21596981.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell. 2011 May 17; 19(5):613-28.
Sheen JH, Zoncu R, Kim D, Sabatini DM. PMID: 21575862.
View in: PubMed Mentions: 83 Fields: Translation: HumansAnimalsCells
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mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011 Jan; 12(1):21-35.
Zoncu R, Efeyan A, Sabatini DM. PMID: 21157483.
View in: PubMed Mentions: 1606 Fields: Translation: HumansAnimalsCells
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The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol. 2010 Aug 09; 190(3):307-15.
Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P. PMID: 20679431.
View in: PubMed Mentions: 47 Fields: Translation: AnimalsCells
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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16; 141(2):290-303.
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. PMID: 20381137.
View in: PubMed Mentions: 861 Fields: Translation: HumansAnimalsCells
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A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J. 2009 Jul 08; 28(13):1831-42.
Mao Y, Balkin DM, Zoncu R, Erdmann KS, Tomasini L, Hu F, Jin MM, Hodsdon ME, De Camilli P. PMID: 19536138.
View in: PubMed Mentions: 49 Fields: Translation: HumansAnimalsCells
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A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell. 2009 Mar 20; 136(6):1110-21.
Zoncu R, Perera RM, Balkin DM, Pirruccello M, Toomre D, De Camilli P. PMID: 19303853.
View in: PubMed Mentions: 149 Fields: Translation: AnimalsCells
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Analyzing protein-protein spatial-temporal dependencies from image sequences using fuzzy temporal random sets. J Comput Biol. 2008 Nov; 15(9):1221-36.
Díaz ME, Ayala G, León T, Zoncu R, Toomre D. PMID: 18973437.
View in: PubMed Mentions: 1 Fields:
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Measuring spatiotemporal dependencies in bivariate temporal random sets with applications to cell biology. IEEE Trans Pattern Anal Mach Intell. 2008 Sep; 30(9):1659-71.
Díaz E, Sebastian R, Ayala G, Díaz ME, Zoncu R, Toomre D, Gasman S. PMID: 18617722.
View in: PubMed Mentions: 2 Fields: Translation: Cells
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Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody. Neoplasia. 2007 Dec; 9(12):1099-110.
Perera RM, Zoncu R, Johns TG, Pypaert M, Lee FT, Mellman I, Old LJ, Toomre DK, Scott AM. PMID: 18084617.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
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A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Dev Cell. 2007 Sep; 13(3):377-90.
Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D, De Camilli P. PMID: 17765681.
View in: PubMed Mentions: 115 Fields: Translation: HumansAnimalsCells
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Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3793-8.
Zoncu R, Perera RM, Sebastian R, Nakatsu F, Chen H, Balla T, Ayala G, Toomre D, De Camilli PV. PMID: 17360432.
View in: PubMed Mentions: 112 Fields: Translation: HumansAnimalsCells
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Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19332-7.
Perera RM, Zoncu R, Lucast L, De Camilli P, Toomre D. PMID: 17158794.
View in: PubMed Mentions: 75 Fields: Translation: AnimalsCells
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Overlapping events with application to image sequences. IEEE Trans Pattern Anal Mach Intell. 2006 Oct; 28(10):1707-12.
Ayala G, Sebastian R, Díaz ME, Díaz E, Zoncu R, Toomre D. PMID: 16986551.
View in: PubMed Mentions: Fields:
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Analysis of spatial dependencies of endocytic proteins based on temporal random sets. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:4175-8.
Sebastian R, Diaz ME, Ayala G, Zoncu R, Toomre D. PMID: 17946228.
View in: PubMed Mentions: Fields:
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Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature. 2002 Nov 07; 420(6911):85-9.
Di Paolo G, Pellegrini L, Letinic K, Cestra G, Zoncu R, Voronov S, Chang S, Guo J, Wenk MR, De Camilli P. PMID: 12422219.
View in: PubMed Mentions: 175 Fields: Translation: HumansAnimalsCells
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Origin of GABAergic neurons in the human neocortex. Nature. 2002 Jun 06; 417(6889):645-9.
Letinic K, Zoncu R, Rakic P. PMID: 12050665.
View in: PubMed Mentions: 210 Fields: Translation: HumansCells
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Year | Publications |
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2002 | 2 | 2006 | 3 | 2007 | 3 | 2008 | 2 | 2009 | 2 | 2010 | 3 | 2011 | 3 | 2012 | 4 | 2013 | 2 | 2015 | 6 | 2016 | 5 | 2017 | 8 | 2018 | 2 | 2019 | 6 | 2020 | 6 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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