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Roberto Zoncu

Title(s)Lecturer, Graduate Med Science Unit
SchoolSchool of Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD. Nature. 2020 09; 585(7824):251-255. Su MY, Fromm SA, Zoncu R, Hurley JH. PMID: 32848248.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. The Lysosome at the Intersection of Cellular Growth and Destruction. Dev Cell. 2020 Jul 20; 54(2):226-238. Shin HR, Zoncu R. PMID: 32610045.
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    3. Lysosomal recycling of amino acids affects ER quality control. Sci Adv. 2020 Jun; 6(26):eaaz9805. Higuchi-Sanabria R, Shen K, Kelet N, Frankino PA, Durieux J, Bar-Ziv R, Sing CN, Garcia EJ, Homentcovschi S, Sanchez M, Wu R, Tronnes SU, Joe L, Webster B, Ahilon-Jeronimo A, Monshietehadi S, Dallarda S, Pender C, Pon LA, Zoncu R, Dillin A. PMID: 32637599.
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    4. A zinc-sensing protein gives flies a gut feeling for growth. Nature. 2020 04; 580(7802):187-188. Citron YR, Zoncu R. PMID: 32203359.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease. Sci Rep. 2020 03 11; 10(1):4528. Bindesbøll C, Aas A, Ogmundsdottir MH, Pankiv S, Reine T, Zoncu R, Simonsen A. PMID: 32161285.
      View in: PubMed   Mentions:    Fields:    
    6. Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science. 2019 11 22; 366(6468):971-977. Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R. PMID: 31672913.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019 11; 575(7784):688-692. Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA. PMID: 31634900.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    8. ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Nat Cell Biol. 2019 10; 21(10):1206-1218. Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R. PMID: 31548609.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 08; 15(8):776-785. Chung CY, Shin HR, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R, Nomura DK. PMID: 31285595.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Rhomboids Distort Time and Space: Accelerated Proteolysis through Membrane Disruption. Biochemistry. 2019 04 23; 58(16):2093-2094. Citron YR, Zoncu R. PMID: 30977995.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    11. The lysosome as a cellular centre for signalling, metabolism and quality control. Nat Cell Biol. 2019 02; 21(2):133-142. Lawrence RE, Zoncu R. PMID: 30602725.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    12. A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold. Nat Cell Biol. 2018 09; 20(9):1052-1063. Lawrence RE, Cho KF, Rappold R, Thrun A, Tofaute M, Kim DJ, Moldavski O, Hurley JH, Zoncu R. PMID: 30061680.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    13. Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage. Mol Cell. 2018 04 05; 70(1):5-7. Shin HR, Zoncu R. PMID: 29625038.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    14. Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors. Cell Rep. 2017 Nov 21; 21(8):2031-2038. De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE. PMID: 29166595.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    15. Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Mol Cell. 2017 Dec 07; 68(5):835-846.e3. Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH. PMID: 29107538.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    16. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov. 2017 11; 7(11):1266-1283. Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK. PMID: 28899863.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    17. Emerging Roles for the Lysosome in Lipid Metabolism. Trends Cell Biol. 2017 11; 27(11):833-850. Thelen AM, Zoncu R. PMID: 28838620.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    18. DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Dev Cell. 2017 07 10; 42(1):9-21.e5. Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. PMID: 28697336.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    19. Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science. 2017 06 16; 356(6343):1188-1192. Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, Di Giovannantonio LG, Nusco E, Platt N, Guida A, Ogmundsdottir MH, Lanfrancone L, Perera RM, Zoncu R, Pelicci PG, Settembre C, Ballabio A. PMID: 28619945.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    20. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science. 2017 03 24; 355(6331):1306-1311. Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. PMID: 28336668.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    21. PhotoGate microscopy to track single molecules in crowded environments. Nat Commun. 2017 01 10; 8:13978. Belyy V, Shih SM, Bandaria J, Huang Y, Lawrence RE, Zoncu R, Yildiz A. PMID: 28071667.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. Dynamics of mTORC1 activation in response to amino acids. Elife. 2016 10 11; 5. Manifava M, Smith M, Rotondo S, Walker S, Niewczas I, Zoncu R, Clark J, Ktistakis NT. PMID: 27725083.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    23. The lysosome as a command-and-control center for cellular metabolism. J Cell Biol. 2016 09 12; 214(6):653-64. Lim CY, Zoncu R. PMID: 27621362.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    24. The Lysosome as a Regulatory Hub. Annu Rev Cell Dev Biol. 2016 10 06; 32:223-253. Perera RM, Zoncu R. PMID: 27501449.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    25. Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8224-9. Young LN, Cho K, Lawrence R, Zoncu R, Hurley JH. PMID: 27385829.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    26. Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet. 2016 05 27; 48(6):700. Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J. PMID: 27230687.
      View in: PubMed   Mentions: 1     Fields:    
    27. Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet. 2016 Feb; 48(2):183-8. Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J. PMID: 26691987.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    28. Identification of an oncogenic RAB protein. Science. 2015 Oct 09; 350(6257):211-7. Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL. PMID: 26338797.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    29. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015 Aug 20; 524(7565):361-5. Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N. PMID: 26168401.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    30. Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science. 2015 Apr 17; 348(6232):340-3. Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM. PMID: 25837514.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    31. Control of cellular homeostasis: organelles take the pilot's seat. Mol Biol Cell. 2015 Mar 15; 26(6):1009-10. Tooze S, Zoncu R. PMID: 25767200.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    32. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 09; 347(6218):188-94. Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. PMID: 25567906.
      View in: PubMed   Mentions: 219     Fields:    Translation:HumansCells
    33. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21; 52(4):495-505. Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM. PMID: 24095279.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    34. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol. 2013 Jul; 31(7):653-8. Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG. PMID: 23792629.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    35. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature. 2013 Jan 31; 493(7434):679-83. Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM. PMID: 23263183.
      View in: PubMed   Mentions: 142     Fields:    Translation:Animals
    36. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 2012 Sep 14; 150(6):1196-208. Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. PMID: 22980980.
      View in: PubMed   Mentions: 316     Fields:    Translation:HumansAnimalsCells
    37. Amino acids and mTORC1: from lysosomes to disease. Trends Mol Med. 2012 Sep; 18(9):524-33. Efeyan A, Zoncu R, Sabatini DM. PMID: 22749019.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansCells
    38. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 2012 Mar 07; 31(5):1095-108. Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A. PMID: 22343943.
      View in: PubMed   Mentions: 497     Fields:    Translation:HumansAnimalsCells
    39. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science. 2011 Nov 04; 334(6056):678-83. Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. PMID: 22053050.
      View in: PubMed   Mentions: 547     Fields:    Translation:HumansAnimalsCells
    40. Cell biology. The TASCC of secretion. Science. 2011 May 20; 332(6032):923-5. Zoncu R, Sabatini DM. PMID: 21596981.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    41. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell. 2011 May 17; 19(5):613-28. Sheen JH, Zoncu R, Kim D, Sabatini DM. PMID: 21575862.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    42. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011 Jan; 12(1):21-35. Zoncu R, Efeyan A, Sabatini DM. PMID: 21157483.
      View in: PubMed   Mentions: 1577     Fields:    Translation:HumansAnimalsCells
    43. The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol. 2010 Aug 09; 190(3):307-15. Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P. PMID: 20679431.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    44. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16; 141(2):290-303. Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. PMID: 20381137.
      View in: PubMed   Mentions: 833     Fields:    Translation:HumansAnimalsCells
    45. A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J. 2009 Jul 08; 28(13):1831-42. Mao Y, Balkin DM, Zoncu R, Erdmann KS, Tomasini L, Hu F, Jin MM, Hodsdon ME, De Camilli P. PMID: 19536138.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    46. A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell. 2009 Mar 20; 136(6):1110-21. Zoncu R, Perera RM, Balkin DM, Pirruccello M, Toomre D, De Camilli P. PMID: 19303853.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    47. Analyzing protein-protein spatial-temporal dependencies from image sequences using fuzzy temporal random sets. J Comput Biol. 2008 Nov; 15(9):1221-36. Díaz ME, Ayala G, León T, Zoncu R, Toomre D. PMID: 18973437.
      View in: PubMed   Mentions: 1     Fields:    
    48. Measuring spatiotemporal dependencies in bivariate temporal random sets with applications to cell biology. IEEE Trans Pattern Anal Mach Intell. 2008 Sep; 30(9):1659-71. Díaz E, Sebastian R, Ayala G, Díaz ME, Zoncu R, Toomre D, Gasman S. PMID: 18617722.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    49. Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody. Neoplasia. 2007 Dec; 9(12):1099-110. Perera RM, Zoncu R, Johns TG, Pypaert M, Lee FT, Mellman I, Old LJ, Toomre DK, Scott AM. PMID: 18084617.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    50. A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Dev Cell. 2007 Sep; 13(3):377-90. Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D, De Camilli P. PMID: 17765681.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    51. Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3793-8. Zoncu R, Perera RM, Sebastian R, Nakatsu F, Chen H, Balla T, Ayala G, Toomre D, De Camilli PV. PMID: 17360432.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    52. Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19332-7. Perera RM, Zoncu R, Lucast L, De Camilli P, Toomre D. PMID: 17158794.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    53. Overlapping events with application to image sequences. IEEE Trans Pattern Anal Mach Intell. 2006 Oct; 28(10):1707-12. Ayala G, Sebastian R, Díaz ME, Díaz E, Zoncu R, Toomre D. PMID: 16986551.
      View in: PubMed   Mentions:    Fields:    
    54. Analysis of spatial dependencies of endocytic proteins based on temporal random sets. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:4175-8. Sebastian R, Diaz ME, Ayala G, Zoncu R, Toomre D. PMID: 17946228.
      View in: PubMed   Mentions:    Fields:    
    55. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature. 2002 Nov 07; 420(6911):85-9. Di Paolo G, Pellegrini L, Letinic K, Cestra G, Zoncu R, Voronov S, Chang S, Guo J, Wenk MR, De Camilli P. PMID: 12422219.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimalsCells
    56. Origin of GABAergic neurons in the human neocortex. Nature. 2002 Jun 06; 417(6889):645-9. Letinic K, Zoncu R, Rakic P. PMID: 12050665.
      View in: PubMed   Mentions: 205     Fields:    Translation:HumansCells
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