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Ronald Clyman, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPediatrics
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-4462
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    Columbia UniversityM.D.1971School of Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Ronald Clyman is a neonatologist and an expert in the treatment of extremely premature infants. He is internationally renowned for his basic and clinical studies of the ductus arteriousus, a blood vessel that transports blood from the right side of the heart to the aorta, which is the large blood vessel that distributes blood to a baby's body while still in the womb. He has helped define the role of oxygen and prostaglandins in ductus patency and is currently studying the mechanisms leading to irreversible ductal closure. Clyman is a professor of pediatrics at the University of California, San Francisco and a member of the Cardiovascular Research Institute. He earned his medical degree at Columbia University and is board certified in pediatrics and neonatal and perinatal medicine.

    Education
    Columbia University School of Medicine 1971


    Collapse Research 
    Collapse Research Activities and Funding
    Genes contributing to patent ductus arteriosus susceptibility in preterm newborns
    NIH/NHLBI R01HL109199Aug 1, 2011 - Jul 31, 2015
    Role: Principal Investigator
    The Southwest National Primate Research Center
    NIH P51RR013986Jun 1, 1999 - Apr 30, 2014
    Role: Co-Investigator
    Closure of the Primate Ductus Arteriosus
    NIH/NHLBI U01HL056061Sep 30, 1995 - Aug 31, 2008
    Role: Principal Investigator
    REGULATION OF THE DUCTUS ARTERIOSUS
    NIH/NHLBI U10HL056061Sep 30, 1995 - Aug 31, 1999
    Role: Principal Investigator
    Vessel Remodeling During Ductus Arteriosus Closure
    NIH/NHLBI R01HL046691Feb 1, 1992 - Mar 31, 2012
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator
    SCOR: RESPIRATORY DISORDERS OF NEONATES AND CHILDREN
    NIH P50HL027356Sep 1, 1981 - Nov 30, 1991
    Role: Co-Investigator
    CARDIOVASCULAR RESPONSES TO STRESS DURING DEVELOPMENT
    NIH P01HL024056Jun 1, 1980 - Dec 31, 1988
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Higgins RD, Jobe AH, Koso-Thomas M, Bancalari E, Viscardi RM, Hartert TV, Ryan RM, Kallapur SG, Steinhorn RH, Konduri GG, Davis SD, Thebaud B, Clyman R, Collaco JM, Martin CR, Woods JC, Finer NN, Raju TNK. Bronchopulmonary Dysplasia: Executive Summary of a Workshop. J Pediatr. 2018 Mar 16. PMID: 29551318.
      View in: PubMed
    2. Clyman R, Liebowitz M. Treatment and Nontreatment of the Patent Ductus Arteriosus: Identifying Their Roles in Neonatal Morbidity. J Pediatr. 2017 Oct; 189:13-17. PMID: 28709633.
      View in: PubMed
    3. Goyal R, Clyman R. Response to Coceani et al. Pediatr Res. 2017 08; 82(2):175. PMID: 28613277.
      View in: PubMed
    4. Liebowitz M, Clyman R. Prophylactic Indomethacin Compared with Delayed Conservative Management of the Patent Ductus Arteriosus in Extremely Preterm Infants: Effects on Neonatal Outcomes. J Pediatr. 2017 Aug; 187:119-126.e1. PMID: 28396025.
      View in: PubMed
    5. Liebowitz M, Koo J, Wickremasinghe A, Allen IE, Clyman R. Effects of Prophylactic Indomethacin on Vasopressor-Dependent Hypotension in Extremely Preterm Infants. J Pediatr. 2017 Mar; 182:21-27.e2. PMID: 27915200.
      View in: PubMed
    6. Liebowitz M, Clyman R. Antenatal Betamethasone: A Prolonged Time Interval from Administration to Delivery Is Associated with an Increased Incidence of Severe Intraventricular Hemorrhage in Infants Born before 28 Weeks Gestation. J Pediatr. 2016 Oct; 177:114-120.e1. PMID: 27514239; PMCID: PMC5037021 [Available on 10/01/17].
    7. Goyal R, Goyal D, Longo LD, Clyman R. Microarray gene expression analysis in ovine ductus arteriosus during fetal development and birth transition. Pediatr Res. 2016 Oct; 80(4):610-8. PMID: 27356085.
      View in: PubMed
    8. Jelin AC, Zlatnik MG, Kuppermann M, Gregorich SE, Nakagawa S, Clyman R. Clamp late and maintain perfusion (CLAMP) policy: delayed cord clamping in preterm infants. J Matern Fetal Neonatal Med. 2016; 29(11):1705-9. PMID: 26135773.
      View in: PubMed
    9. Waleh N, Barrette AM, Dagle JM, Momany A, Jin C, Hills NK, Shelton EL, Reese J, Clyman R. Effects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene Expression. J Pediatr. 2015 Nov; 167(5):1033-41.e2. PMID: 26265282; PMCID: PMC4661123 [Available on 11/01/16].
    10. Simon SR, van Zogchel L, Bas-Suárez MP, Cavallaro G, Clyman R, Villamor E. Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis. Neonatology. 2015; 108(2):143-51. PMID: 26159239.
      View in: PubMed
    11. Liebowitz MC, Clyman R. Predicting the Need for Home Oxygen Therapy in Preterm Infants Born Before 28 Weeks' Gestation. Am J Perinatol. 2016 Jan; 33(1):34-9. PMID: 26084746.
      View in: PubMed
    12. Heuchan AM, Clyman R. Managing the patent ductus arteriosus: current treatment options. Arch Dis Child Fetal Neonatal Ed. 2014 Sep; 99(5):F431-6. PMID: 24903455.
      View in: PubMed
    13. Clyman R, Wickremasinghe A, Merritt TA, Solomon T, McNamara P, Jain A, Singh J, Chu A, Noori S, Sekar K, Lavoie PM, Attridge JT, Swanson JR, Gillam-Krakauer M, Reese J, DeMauro S, Poindexter B, Aucott S, Satpute M, Fernandez E, Auchus RJ. Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones. J Pediatr. 2014 Jun; 164(6):1449-55.e1. PMID: 24636853; PMCID: PMC4035426.
    14. Jelin AC, Kuppermann M, Erickson K, Clyman R, Schulkin J. Obstetricians' attitudes and beliefs regarding umbilical cord clamping. J Matern Fetal Neonatal Med. 2014 Sep; 27(14):1457-61. PMID: 24215582.
      View in: PubMed
    15. Yanowitz TD, Reese J, Gillam-Krakauer M, Cochran CM, Jegatheesan P, Lau J, Tran VT, Walsh M, Carey WA, Fujii A, Fabio A, Clyman R. Superior mesenteric artery blood flow velocities following medical treatment of a patent ductus arteriosus. J Pediatr. 2014 Mar; 164(3):661-3. PMID: 24321538; PMCID: PMC4077598.
    16. Clyman R. The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia. Semin Perinatol. 2013 Apr; 37(2):102-7. PMID: 23582964; PMCID: PMC3627220.
    17. Clyman R, Wickremasinghe A, Jhaveri N, Hassinger DC, Attridge JT, Sanocka U, Polin R, Gillam-Krakauer M, Reese J, Mammel M, Couser R, Mulrooney N, Yanowitz TD, Derrick M, Jegatheesan P, Walsh M, Fujii A, Porta N, Carey WA, Swanson JR. Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus. J Pediatr. 2013 Aug; 163(2):406-11. PMID: 23472765; PMCID: PMC3683087.
    18. Catenacci M, Miyagi S, Wickremasinghe AC, Lucas SS, de Alba Campomanes AG, Good WV, Clyman R. Dopamine-resistant hypotension and severe retinopathy of prematurity. J Pediatr. 2013 Aug; 163(2):400-5. PMID: 23465406; PMCID: PMC3676698.
    19. Wickremasinghe AC, Rogers EE, Piecuch RE, Johnson BC, Golden S, Moon-Grady AJ, Clyman R. Neurodevelopmental outcomes following two different treatment approaches (early ligation and selective ligation) for patent ductus arteriosus. J Pediatr. 2012 Dec; 161(6):1065-72. PMID: 22795222; PMCID: PMC3474858.
    20. Clyman R. Surgical ligation of the patent ductus arteriosus: treatment or morbidity? J Pediatr. 2012 Oct; 161(4):583-4. PMID: 22795223.
      View in: PubMed
    21. Clyman R, Couto J, Murphy GM. Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? Semin Perinatol. 2012 Apr; 36(2):123-9. PMID: 22414883; PMCID: PMC3305915.
    22. Sutherland MR, Yoder BA, McCurnin D, Seidner S, Gubhaju L, Clyman R, Black MJ. Effects of ibuprofen treatment on the developing preterm baboon kidney. Am J Physiol Renal Physiol. 2012 May 15; 302(10):F1286-92. PMID: 22357916; PMCID: PMC3362063.
    23. Waleh N, Seidner S, McCurnin D, Giavedoni L, Hodara V, Goelz S, Liu BM, Roman C, Clyman R. Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation. Pediatr Res. 2011 Oct; 70(4):332-8. PMID: 21691249; PMCID: PMC3166370.
    24. Waleh N, McCurnin DC, Yoder BA, Shaul PW, Clyman R. Patent ductus arteriosus ligation alters pulmonary gene expression in preterm baboons. Pediatr Res. 2011 Mar; 69(3):212-6. PMID: 21131894; PMCID: PMC3065199.
    25. Shah NA, Hills NK, Waleh N, McCurnin D, Seidner S, Chemtob S, Clyman R. Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment. J Pediatr. 2011 Jun; 158(6):919-923.e1-2. PMID: 21195414; PMCID: PMC3095765.
    26. Waleh N, Hodnick R, Jhaveri N, McConaghy S, Dagle J, Seidner S, McCurnin D, Murray JC, Ohls R, Clyman R. Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency. Pediatr Res. 2010 Oct; 68(4):292-7. PMID: 20581741; PMCID: PMC2940964.
    27. Loeliger M, Shields A, McCurnin D, Clyman R, Yoder B, Inder TE, Rees SM. Ibuprofen treatment for closure of patent ductus arteriosus is not associated with increased risk of neuropathology. Pediatr Res. 2010 Oct; 68(4):298-302. PMID: 20581742; PMCID: PMC2976654.
    28. Jhaveri N, Moon-Grady A, Clyman R. Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment. J Pediatr. 2010 Sep; 157(3):381-7, 387.e1. PMID: 20434168; PMCID: PMC2926149.
    29. Jhaveri N, Soll RF, Clyman R. Feeding practices and patent ductus arteriosus ligation preferences-are they related? Am J Perinatol. 2010 Sep; 27(8):667-74. PMID: 20225172.
      View in: PubMed
    30. Clyman R, Chemtob S. Vessel remodeling in the newborn: platelets fill the gap. Nat Med. 2010 Jan; 16(1):33-5. PMID: 20057422.
      View in: PubMed
    31. Reese J, Waleh N, Poole SD, Brown N, Roman C, Clyman R. Chronic in utero cyclooxygenase inhibition alters PGE2-regulated ductus arteriosus contractile pathways and prevents postnatal closure. Pediatr Res. 2009 Aug; 66(2):155-61. PMID: 19390487; PMCID: PMC3066019.
    32. Clyman R, Cassady G, Kirklin JK, Collins M, Philips JB. The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial. J Pediatr. 2009 Jun; 154(6):873-6. PMID: 19324366; PMCID: PMC2709418.
    33. Waleh N, Reese J, Kajino H, Roman C, Seidner S, McCurnin D, Clyman R. Oxygen-induced tension in the sheep ductus arteriosus: effects of gestation on potassium and calcium channel regulation. Pediatr Res. 2009 Mar; 65(3):285-90. PMID: 19092721; PMCID: PMC2692833.
    34. Loeliger M, Inder TE, Dalitz PA, Cain S, Camm EJ, Yoder B, McCurnin D, Shaul PW, Clyman R, Rees SM. Developmental and neuropathological consequences of ductal ligation in the preterm baboon. Pediatr Res. 2009 Feb; 65(2):209-14. PMID: 19047953; PMCID: PMC2686107.
    35. McCurnin DC, Pierce RA, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard PL, Clyman R, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW. Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):492-500. PMID: 19151197; PMCID: PMC2654978.
    36. Aranda JV, Clyman R, Cox B, Van Overmeire B, Wozniak P, Sosenko I, Carlo WA, Ward RM, Shalwitz R, Baggs G, Seth A, Darko L. A randomized, double-blind, placebo-controlled trial on intravenous ibuprofen L-lysine for the early closure of nonsymptomatic patent ductus arteriosus within 72 hours of birth in extremely low-birth-weight infants. Am J Perinatol. 2009 Mar; 26(3):235-45. PMID: 19067286.
      View in: PubMed
    37. McCurnin D, Clyman R. Effects of a patent ductus arteriosus on postprandial mesenteric perfusion in premature baboons. Pediatrics. 2008 Dec; 122(6):e1262-7. PMID: 19001037; PMCID: PMC2597012.
    38. Liu H, Manganiello V, Waleh N, Clyman R. Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus. Pediatr Res. 2008 Nov; 64(5):477-81. PMID: 18552705; PMCID: PMC2613857.
    39. Ivey KN, Sutcliffe D, Richardson J, Clyman R, Garcia JA, Srivastava D. Transcriptional regulation during development of the ductus arteriosus. Circ Res. 2008 Aug 15; 103(4):388-95. PMID: 18635823; PMCID: PMC2645272.
    40. McCurnin D, Seidner S, Chang LY, Waleh N, Ikegami M, Petershack J, Yoder B, Giavedoni L, Albertine KH, Dahl MJ, Wang ZM, Clyman R. Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung. Pediatrics. 2008 May; 121(5):945-56. PMID: 18450898.
      View in: PubMed
    41. Jegatheesan P, Ianus V, Buchh B, Yoon G, Chorne N, Ewig A, Lin E, Fields S, Moon-Grady A, Tacy T, Milstein J, Schreiber M, Padbury J, Clyman R. Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial. J Pediatr. 2008 Aug; 153(2):183-9. PMID: 18534218.
      View in: PubMed
    42. Chang LY, McCurnin D, Yoder B, Shaul PW, Clyman R. Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus. Pediatr Res. 2008 Mar; 63(3):299-302. PMID: 18287969.
      View in: PubMed
    43. Chorne N, Jegatheesan P, Lin E, Shi R, Clyman R. Risk factors for persistent ductus arteriosus patency during indomethacin treatment. J Pediatr. 2007 Dec; 151(6):629-34. PMID: 18035143.
      View in: PubMed
    44. Clyman R, Roman C. The effects of caffeine on the preterm sheep ductus arteriosus. Pediatr Res. 2007 Aug; 62(2):167-9. PMID: 17597645.
      View in: PubMed
    45. Clyman R, Waleh N, Kajino H, Roman C, Mauray F. Calcium-dependent and calcium-sensitizing pathways in the mature and immature ductus arteriosus. Am J Physiol Regul Integr Comp Physiol. 2007 Oct; 293(4):R1650-6. PMID: 17652360.
      View in: PubMed
    46. Chorne N, Leonard C, Piecuch R, Clyman R. Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity. Pediatrics. 2007 Jun; 119(6):1165-74. PMID: 17545385.
      View in: PubMed
    47. Clyman R, Chorne N. Patent ductus arteriosus: evidence for and against treatment. J Pediatr. 2007 Mar; 150(3):216-9. PMID: 17307530; PMCID: PMC2723062.
    48. Clyman R, Saha S, Jobe A, Oh W. Indomethacin prophylaxis for preterm infants: the impact of 2 multicentered randomized controlled trials on clinical practice. J Pediatr. 2007 Jan; 150(1):46-50.e2. PMID: 17188612; PMCID: PMC1849955.
    49. Reese J, Anderson JD, Brown N, Roman C, Clyman R. Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice. Am J Physiol Regul Integr Comp Physiol. 2006 Dec; 291(6):R1717-1723. PMID: 16857891; PMCID: PMC2819844.
    50. Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman R, Yoder BA, Crapo JD, White CW. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J. 2006 Aug; 20(10):1698-700. PMID: 16807366.
      View in: PubMed
    51. Clyman R. Mechanisms regulating the ductus arteriosus. Biol Neonate. 2006; 89(4):330-5. PMID: 16770073.
      View in: PubMed
    52. Asikainen TM, Waleh NS, Schneider BK, Clyman R, White CW. Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo. Am J Physiol Lung Cell Mol Physiol. 2006 Oct; 291(4):L588-95. PMID: 16679381.
      View in: PubMed
    53. Miller SP, Mayer EE, Clyman R, Glidden DV, Hamrick SE, Barkovich AJ. Prolonged indomethacin exposure is associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks' gestation at birth. Pediatrics. 2006 May; 117(5):1626-31. PMID: 16651316.
      View in: PubMed
    54. Keller RL, Tacy TA, Fields S, Ofenstein JP, Aranda JV, Clyman R. Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns. Pediatr Res. 2005 Dec; 58(6):1216-21. PMID: 16306196.
      View in: PubMed
    55. Levin M, McCurnin D, Seidner SR, Yoder B, Waleh N, Goldbarg S, Roman C, Liu BM, Borén J, Clyman R. Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus arteriosus. Am J Physiol Regul Integr Comp Physiol. 2006 Feb; 290(2):R359-64. PMID: 16223843.
      View in: PubMed
    56. McCurnin DC, Yoder BA, Coalson J, Grubb P, Kerecman J, Kupferschmid J, Breuer C, Siler-Khodr T, Shaul PW, Clyman R. Effect of ductus ligation on cardiopulmonary function in premature baboons. Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1569-74. PMID: 16179644; PMCID: PMC2718457.
    57. Asikainen TM, Schneider BK, Waleh NS, Clyman R, Ho WB, Flippin LA, Günzler V, White CW. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10212-7. PMID: 16009933; PMCID: PMC1177409.
    58. Levin M, Goldbarg S, Lindqvist A, Swärd K, Roman C, Liu BM, Hultén LM, Borén J, Clyman R. ATP depletion and cell death in the neonatal lamb ductus arteriosus. Pediatr Res. 2005 Jun; 57(6):801-5. PMID: 15774827.
      View in: PubMed
    59. Waleh N, Seidner S, McCurnin D, Yoder B, Liu BM, Roman C, Mauray F, Clyman R. The role of monocyte-derived cells and inflammation in baboon ductus arteriosus remodeling. Pediatr Res. 2005 Feb; 57(2):254-62. PMID: 15611359.
      View in: PubMed
    60. Waleh N, Kajino H, Marrache AM, Ginzinger D, Roman C, Seidner SR, Moss TJ, Fouron JC, Vazquez-Tello A, Chemtob S, Clyman R. Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control. Circulation. 2004 Oct 19; 110(16):2326-32. PMID: 15477420.
      View in: PubMed
    61. Vazquez-Tello A, Fan L, Hou X, Joyal JS, Mancini JA, Quiniou C, Clyman R, Gobeil F, Varma DR, Chemtob S. Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain. Am J Physiol Regul Integr Comp Physiol. 2004 Nov; 287(5):R1155-63. PMID: 15284079.
      View in: PubMed
    62. Clyman R. Oxygen-saturation targets and outcomes in extremely preterm infants. J Pediatr. 2004 Mar; 144(3):408. PMID: 15032225.
      View in: PubMed
    63. Bouayad A, Fouron JC, Hou X, Beauchamp M, Quiniou C, Abran D, Peri K, Clyman R, Varma DR, Chemtob S. Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus. Am J Physiol Regul Integr Comp Physiol. 2004 May; 286(5):R903-9. PMID: 14715488.
      View in: PubMed
    64. Keller RL, Clyman R. Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus. Pediatrics. 2003 Sep; 112(3 Pt 1):583-7. PMID: 12949288.
      View in: PubMed
    65. Goldbarg S, Quinn T, Waleh N, Roman C, Liu BM, Mauray F, Clyman R. Effects of hypoxia, hypoglycemia, and muscle shortening on cell death in the sheep ductus arteriosus. Pediatr Res. 2003 Aug; 54(2):204-11. PMID: 12736384.
      View in: PubMed
    66. Quinn D, Cooper B, Clyman R. Factors associated with permanent closure of the ductus arteriosus: a role for prolonged indomethacin therapy. Pediatrics. 2002 Jul; 110(1 Pt 1):e10. PMID: 12093991.
      View in: PubMed
    67. Kajino H, Goldbarg S, Roman C, Liu BM, Mauray F, Chen YQ, Takahashi Y, Koch CJ, Clyman R. Vasa vasorum hypoperfusion is responsible for medial hypoxia and anatomic remodeling in the newborn lamb ductus arteriosus. Pediatr Res. 2002 Feb; 51(2):228-35. PMID: 11809919.
      View in: PubMed
    68. Goldbarg SH, Takahashi Y, Cruz C, Kajino H, Roman C, Liu BM, Chen YQ, Mauray F, Clyman R. In utero indomethacin alters O2 delivery to the fetal ductus arteriosus: implications for postnatal patency. Am J Physiol Regul Integr Comp Physiol. 2002 Jan; 282(1):R184-90. PMID: 11742837.
      View in: PubMed
    69. Kajino H, Roman C, Clyman R. Renal effects of cyclooxygenase-2 inhibition in fetal lambs. Biol Neonate. 2002; 82(4):257-62. PMID: 12381934.
      View in: PubMed
    70. Clyman R, Seidner SR, Kajino H, Roman C, Koch CJ, Ferrara N, Waleh N, Mauray F, Chen YQ, Perkett EA, Quinn T. VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus. Am J Physiol Regul Integr Comp Physiol. 2002 Jan; 282(1):R199-206. PMID: 11742839.
      View in: PubMed