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Ronald Krauss, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address513 Parnassus Ave
San Francisco CA 94143
Phone510-525-0160
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    Collapse Overview 
    Collapse Overview
    Dr. Krauss' research program focuses on plasma lipoprotein metabolism and related traits that influence risk for coronary artery disease. His laboratory developed and applied methodology that led to the discovery of a common genetically-influenced atherogenic lipoprotein phenotype that underlies cardiovascular disease risk in patients with obesity, type 2 diabetes, and metabolic syndrome. A major current research emphasis has been the identification of genetic determinants of the wide range of inter-individual variability in phenotypic and clinical response to statin treatment. Multiple statin-treated population samples are being examined to test the reproducibility and generalizability of findings derived from both candidate gene and genome-wide searches for SNP associations with markers of statin efficacy as well as muscle toxicity. Functional significance of genetic findings is being evaluated in appropriate human cellular and animal models, with the goal of connecting genotypes to clinically relevant determinants of cardiovascular disease risk.


    Collapse Research 
    Collapse Research Activities and Funding
    Pharmacogenomics of Statin Therapy
    NIH/NIGMS P50GM115318Sep 7, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Genetic Etiology of Cancer Drug Response
    NIH/NCI R01CA161608Mar 1, 2012 - Mar 31, 2022
    Role: Co-Principal Investigator
    Saturated Fat and Protein Effects on Atherogenic Dyslipidemia
    NIH/NHLBI R01HL106003Aug 18, 2011 - May 31, 2016
    Role: Principal Investigator
    Effects of resistant starch on lipid and glucose metabolism in insulin resistance
    NIH/NIDDK RC1DK086472Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Genetic and Molecular Approaches To Cardiovascular Disease
    NIH/NHLBI T32HL098057Sep 1, 2009 - Aug 31, 2014
    Role: Principal Investigator
    HMG-CoA reductase alternative splicing and LDL response to statin
    NIH/NHLBI R21HL093507Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    NCMHD Center of Excellence in Nutritional Genomics
    NIH P60MD000222Jan 15, 2003 - Dec 31, 2010
    Role: Co-Investigator
    Pharmacogenomics and Risk of Cardiovascular Disease
    NIH/NHLBI U19HL069757Sep 27, 2001 - Jun 30, 2015
    Role: Principal Investigator
    Pharmacogenomics and Risk of Cardiovascular Disease
    NIH/NHLBI U01HL069757Sep 27, 2001 - Jul 31, 2010
    Role: Principal Investigator
    COMPARATIVE GENOMIC ANALYSIS OF CARDIOVASCULAR GENE REGU
    NIH/NHLBI U01HL066691Sep 30, 2000 - Jul 31, 2004
    Role: Principal Investigator
    The Southwest National Primate Research Center
    NIH P51RR013986Jun 1, 1999 - Apr 30, 2014
    Role: Co-Investigator
    PLASMA LIPOPROTEINS IN CORONARY ARTERY DISEASE
    NIH/NHLBI R01HL033577Dec 1, 1984 - Nov 30, 1992
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator
    LIPOPROTEINS AND ATHEROGENESIS IN TRANSGENIC ANIMALS
    NIH/NHLBI P01HL018574Apr 1, 1976 - Sep 29, 2004
    Role: Principal Investigator
    Administrative Core - Pharmacogenomics of Statin Therapy (POST)
    NIH/NIGMS P50GM-01
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wei WQ, Li X, Feng Q, Kubo M, Kullo IJ, Peissig PL, Karlson EW, Jarvik GP, Lee MTM, Shang N, Larson EA, Edwards T, Shaffer C, Mosley JD, Maeda S, Horikoshi M, Ritchie M, Williams MS, Larson EB, Crosslin DR, Bland ST, Pacheco JA, Rasmussen-Torvik LJ, Cronkite D, Hripcsak G, Cox NJ, Wilke RA, Stein CM, Rotter JI, Momozawa Y, Roden DM, Krauss R, Denny JC. LPA Variants are Associated with Residual Cardiovascular Risk in Patients Receiving Statins. Circulation. 2018 Apr 27. PMID: 29703846.
      View in: PubMed
    2. Mach F, Ray KK, Wiklund O, Corsini A, Catapano AL, Bruckert E, De Backer G, Hegele RA, Hovingh GK, Jacobson TA, Krauss R, Laufs U, Leiter LA, März W, Nordestgaard BG, Raal FJ, Roden M, Santos RD, Stein EA, Stroes ES, Thompson PD, Tokgözoglu L, Vladutiu GD, Gencer B, Stock JK, Ginsberg HN, Chapman MJ. Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. Eur Heart J. 2018 Apr 27. PMID: 29718253.
      View in: PubMed
    3. Liang X, Yee SW, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss R, Giacomini KM. Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. PLoS Biol. 2018 Apr 16; 16(4):e2002907. PMID: 29659562.
      View in: PubMed
    4. Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss R, Iribarren C, Risch N. A large electronic-health-record-based genome-wide study of serum lipids. Nat Genet. 2018 Mar; 50(3):401-413. PMID: 29507422.
      View in: PubMed
    5. Sun H, Krauss R, Chang JT, Teng BB. PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction. J Lipid Res. 2018 Feb; 59(2):207-223. PMID: 29180444.
      View in: PubMed
    6. Maier TV, Lucio M, Lee LH, VerBerkmoes NC, Brislawn CJ, Bernhardt J, Lamendella R, McDermott JE, Bergeron N, Heinzmann SS, Morton JT, González A, Ackermann G, Knight R, Riedel K, Krauss R, Schmitt-Kopplin P, Jansson JK. Impact of Dietary Resistant Starch on the Human Gut Microbiome, Metaproteome, and Metabolome. MBio. 2017 Oct 17; 8(5). PMID: 29042495.
      View in: PubMed
    7. Zhang M, Lei D, Peng B, Yang M, Zhang L, Charles MA, Rye KA, Krauss R, Johns DG, Ren G. Assessing the mechanisms of cholesteryl ester transfer protein inhibitors. Biochim Biophys Acta. 2017 12; 1862(12):1606-1617. PMID: 28911944.
      View in: PubMed
    8. Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, Hegele RA, Krauss R, Raal FJ, Schunkert H, Watts GF, Borén J, Fazio S, Horton JD, Masana L, Nicholls SJ, Nordestgaard BG, van de Sluis B, Taskinen MR, Tokgözoglu L, Landmesser U, Laufs U, Wiklund O, Stock JK, Chapman MJ, Catapano AL. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2017 Aug 21; 38(32):2459-2472. PMID: 28444290.
      View in: PubMed
    9. Saleheen D, Natarajan P, Armean IM, Zhao W, Rasheed A, Khetarpal SA, Won HH, Karczewski KJ, O'Donnell-Luria AH, Samocha KE, Weisburd B, Gupta N, Zaidi M, Samuel M, Imran A, Abbas S, Majeed F, Ishaq M, Akhtar S, Trindade K, Mucksavage M, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Hayyat Mallick N, Ishaq M, Rasheed SZ, Memon FU, Mahmood K, Ahmed N, Do R, Krauss R, MacArthur DG, Gabriel S, Lander ES, Daly MJ, Frossard P, Danesh J, Rader DJ, Kathiresan S. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017 04 12; 544(7649):235-239. PMID: 28406212.
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    10. Jenkins BJ, Seyssel K, Chiu S, Pan PH, Lin SY, Stanley E, Ament Z, West JA, Summerhill K, Griffin JL, Vetter W, Autio KJ, Hiltunen K, Hazebrouck S, Stepankova R, Chen CJ, Alligier M, Laville M, Moore M, Kraft G, Cherrington A, King S, Krauss R, de Schryver E, Van Veldhoven PP, Ronis M, Koulman A. Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance. Sci Rep. 2017 Mar 23; 7:44845. PMID: 28332596.
      View in: PubMed
    11. Chiu S, Williams PT, Krauss R. Effects of a very high saturated fat diet on LDL particles in adults with atherogenic dyslipidemia: A randomized controlled trial. PLoS One. 2017; 12(2):e0170664. PMID: 28166253.
      View in: PubMed
    12. Mendelson MM, Marioni RE, Joehanes R, Liu C, Hedman ÅK, Aslibekyan S, Demerath EW, Guan W, Zhi D, Yao C, Huan T, Willinger C, Chen B, Courchesne P, Multhaup M, Irvin MR, Cohain A, Schadt EE, Grove ML, Bressler J, North K, Sundström J, Gustafsson S, Shah S, McRae AF, Harris SE, Gibson J, Redmond P, Corley J, Murphy L, Starr JM, Kleinbrink E, Lipovich L, Visscher PM, Wray NR, Krauss R, Fallin D, Feinberg A, Absher DM, Fornage M, Pankow JS, Lind L, Fox C, Ingelsson E, Arnett DK, Boerwinkle E, Liang L, Levy D, Deary IJ. Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach. PLoS Med. 2017 Jan; 14(1):e1002215. PMID: 28095459.
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    13. Hedman ÅK, Mendelson MM, Marioni RE, Gustafsson S, Joehanes R, Irvin MR, Zhi D, Sandling JK, Yao C, Liu C, Liang L, Huan T, McRae AF, Demissie S, Shah S, Starr JM, Cupples LA, Deloukas P, Spector TD, Sundström J, Krauss R, Arnett DK, Deary IJ, Lind L, Levy D, Ingelsson E. Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies. Circ Cardiovasc Genet. 2017 Jan; 10(1). PMID: 28213390.
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    14. Mendoza S, Trenchevska O, King SM, Nelson RW, Nedelkov D, Krauss R, Yassine HN. Changes in low-density lipoprotein size phenotypes associate with changes in apolipoprotein C-III glycoforms after dietary interventions. J Clin Lipidol. 2017 Jan - Feb; 11(1):224-233.e2. PMID: 28391889.
      View in: PubMed
    15. Elbadawi-Sidhu M, Baillie RA, Zhu H, Chen YI, Goodarzi MO, Rotter JI, Krauss R, Fiehn O, Kaddurah-Daouk R. Pharmacometabolomic signature links simvastatin therapy and insulin resistance. Metabolomics (Los Angel). 2017 Jan; 13. PMID: 29732238.
      View in: PubMed
    16. Bergeron N, Williams PT, Lamendella R, Faghihnia N, Grube A, Li X, Wang Z, Knight R, Jansson JK, Hazen SL, Krauss R. Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk. Br J Nutr. 2016 Dec; 116(12):2020-2029. PMID: 27993177.
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    17. Smit RA, Postmus I, Trompet S, Barnes MR, Warren H, Arsenault BJ, Chasman DI, Cupples LA, Hitman GA, Krauss R, Li X, Psaty BM, Stein CM, Rotter JI, Jukema JW. Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment. Pharmacogenomics. 2016 Oct; 17(15):1621-1628. PMID: 27648687.
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    18. Siri-Tarino PW, Krauss R. Which cheese to choose? Am J Clin Nutr. 2016 10; 104(4):953-954. PMID: 27629048.
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    19. Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S, Kleber ME, Guo X, Lyytikäinen LP, Fava C, Eriksson N, Nolte IM, Magnusson PK, Salfati EL, Rallidis LS, Theusch E, Smith AJP, Folkersen L, Witkowska K, Pers TH, Joehanes R, Kim SK, Lataniotis L, Jansen R, Johnson AD, Warren H, Kim YJ, Zhao W, Wu Y, Tayo BO, Bochud M. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet. 2016 10; 48(10):1171-1184. PMID: 27618452.
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    20. Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, Taylor KD, Arnold AM, Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YI, de Craen AJ, Cummings SR, Denny JC, Dubé MP, Durrington PN, Eiriksdottir G, Ford I, Guo X, Harris TB, Heckbert SR, Hofman A, Hovingh GK, Kastelein JJ, Launer LJ, Liu CT, Liu Y, Lumley T, McKeigue PM, Munroe PB, Neil A, Nickerson DA, Nyberg F, O'Brien E, O'Donnell CJ, Post W, Poulter N, Vasan RS, Rice K, Rich SS, Rivadeneira F, Sattar N, Sever P, Shaw-Hawkins S, Shields DC, Slagboom PE, Smith NL, Smith JD, Sotoodehnia N, Stanton A, Stott DJ, Stricker BH, Stürmer T, Uitterlinden AG, Wei WQ, Westendorp RG, Whitsel EA, Wiggins KL, Wilke RA, Ballantyne CM, Colhoun HM, Cupples LA, Franco OH, Gudnason V, Hitman G, Palmer CN, Psaty BM, Ridker PM, Stafford JM, Stein CM, Tardif JC, Caulfield MJ, Jukema JW, Rotter JI, Krauss R. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. J Med Genet. 2016 12; 53(12):835-845. PMID: 27587472.
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    21. Yu Y, Kuang YL, Lei D, Zhai X, Zhang M, Krauss R, Ren G. Polyhedral 3D structure of human plasma very low density lipoproteins by individual particle cryo-electron tomography1. J Lipid Res. 2016 10; 57(10):1879-1888. PMID: 27538822.
      View in: PubMed
    22. Siri-Tarino PW, Krauss R. Diet, lipids, and cardiovascular disease. Curr Opin Lipidol. 2016 Aug; 27(4):323-8. PMID: 27389628.
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    23. Siri-Tarino PW, Krauss R. The early years of lipoprotein research: from discovery to clinical application. J Lipid Res. 2016 10; 57(10):1771-1777. PMID: 27474223.
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    24. Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P, Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, Li M, Lipovich L, Rybin DV, Taylor KD, Agyemang C, Palmer ND, Cade BE, Chen WM, Dauriz M, Delaney JA, Edwards TL, Evans DS, Evans MK, Lange LA, Leong A, Liu J, Liu Y, Nayak U, Patel SR, Porneala BC, Rasmussen-Torvik LJ, Snijder MB, Stallings SC, Tanaka T, Yanek LR, Zhao W, Becker DM, Bielak LF, Biggs ML, Bottinger EP, Bowden DW, Chen G, Correa A, Couper DJ, Crawford DC, Cushman M, Eicher JD, Fornage M, Franceschini N, Fu YP, Goodarzi MO, Gottesman O, Hara K, Harris TB, Jensen RA, Johnson AD, Jhun MA, Karter AJ, Keller MF, Kho AN, Kizer JR, Krauss R, Langefeld CD, Li X, Liang J, Liu S, Lowe WL, Mosley TH, North KE, Pacheco JA, Peyser PA, Patrick AL, Rice KM, Selvin E, Sims M, Smith JA, Tajuddin SM, Vaidya D, Wren MP, Yao J, Zhu X, Ziegler JT, Zmuda JM, Zonderman AB, Zwinderman AH. Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am J Hum Genet. 2016 Jul 07; 99(1):56-75. PMID: 27321945.
      View in: PubMed
    25. Han ES, Krauss R, Xu F, Sridhar SB, Ferrara A, Quesenberry CP, Hedderson MM. Prepregnancy Adverse Lipid Profile and Subsequent Risk of Gestational Diabetes. J Clin Endocrinol Metab. 2016 07; 101(7):2721-7. PMID: 27045641.
      View in: PubMed
    26. Alvarellos ML, Krauss R, Wilke RA, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for RYR1. Pharmacogenet Genomics. 2016 Mar; 26(3):138-44. PMID: 26709912; PMCID: PMC4738161.
    27. Lamarche B, Givens DI, Soedamah-Muthu S, Krauss R, Jakobsen MU, Bischoff-Ferrari HA, Pan A, Després JP. Does Milk Consumption Contribute to Cardiometabolic Health and Overall Diet Quality? Can J Cardiol. 2016 Aug; 32(8):1026-32. PMID: 27118060.
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    28. Chiu S, Bergeron N, Williams PT, Bray GA, Sutherland B, Krauss R. Comparison of the DASH (Dietary Approaches to Stop Hypertension) diet and a higher-fat DASH diet on blood pressure and lipids and lipoproteins: a randomized controlled trial. Am J Clin Nutr. 2016 Feb; 103(2):341-7. PMID: 26718414; PMCID: PMC4733264 [Available on 02/01/17].
    29. Gebauer SK, Destaillats F, Dionisi F, Krauss R, Baer DJ. Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial. Am J Clin Nutr. 2015 Dec; 102(6):1339-46. PMID: 26561632.
      View in: PubMed
    30. Forte TM, Krauss R. In Memoriam: Alexander V. Nichols (1924 – 2015). J Lipid Res. 2015 Nov; 56(11):2043-4. PMID: 26423521; PMCID: PMC4617390 [Available on 11/01/16].
    31. Bergeron N, Phan BA, Ding Y, Fong A, Krauss R. Proprotein convertase subtilisin/kexin type 9 inhibition: a new therapeutic mechanism for reducing cardiovascular disease risk. Circulation. 2015 Oct 27; 132(17):1648-66. PMID: 26503748.
      View in: PubMed
    32. Ketefian A, Jones MR, Krauss R, Chen YD, Legro RS, Azziz R, Goodarzi MO. Association study of androgen signaling pathway genes in polycystic ovary syndrome. Fertil Steril. 2016 Feb; 105(2):467-73.e4. PMID: 26493122.
      View in: PubMed
    33. Anand SS, Hawkes C, de Souza RJ, Mente A, Dehghan M, Nugent R, Zulyniak MA, Weis T, Bernstein AM, Krauss R, Kromhout D, Jenkins DJA, Malik V, Martinez-Gonzalez MA, Mozaffarian D, Yusuf S, Willett WC, Popkin BM. Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System: A Report From the Workshop Convened by the World Heart Federation. J Am Coll Cardiol. 2015 Oct 06; 66(14):1590-1614. PMID: 26429085; PMCID: PMC4597475.
    34. Kim C, Kong S, Krauss R, Stanczyk FZ, Reddy ST, Needham BL, Kanaya AM. Endogenous Sex Steroid Hormones, Lipid Subfractions, and Ectopic Adiposity in Asian Indians. Metab Syndr Relat Disord. 2015 Dec; 13(10):445-52. PMID: 26431374; PMCID: PMC4696444 [Available on 12/01/16].
    35. Mora S, Caulfield MP, Wohlgemuth J, Chen Z, Superko HR, Rowland CM, Glynn RJ, Ridker PM, Krauss R. Atherogenic Lipoprotein Subfractions Determined by Ion Mobility and First Cardiovascular Events After Random Allocation to High-Intensity Statin or Placebo: The Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial. Circulation. 2015 Dec 08; 132(23):2220-9. PMID: 26408274; PMCID: PMC4674425 [Available on 12/08/16].
    36. Luzum JA, Theusch E, Taylor KD, Wang A, Sadee W, Binkley PF, Krauss R, Medina MW, Kitzmiller JP. Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations. J Cardiovasc Pharmacol. 2015 Jul; 66(1):80-5. PMID: 26164721; PMCID: PMC4503374.
    37. Melander O, Shiffman D, Caulfield MP, Louie JZ, Rowland CM, Devlin JJ, Krauss R. Low-Density Lipoprotein Particle Number Is Associated With Cardiovascular Events Among Those Not Classified Into Statin Benefit Groups. J Am Coll Cardiol. 2015 Jun 16; 65(23):2571-3. PMID: 26065997.
      View in: PubMed
    38. Shim H, Chasman DI, Smith JD, Mora S, Ridker PM, Nickerson DA, Krauss R, Stephens M. A multivariate genome-wide association analysis of 10 LDL subfractions, and their response to statin treatment, in 1868 Caucasians. PLoS One. 2015; 10(4):e0120758. PMID: 25898129; PMCID: PMC4405269.
    39. McCann JC, Shigenaga MK, Mietus-Snyder ML, Lal A, Suh JH, Krauss R, Gildengorin GL, Goldrich AM, Block DS, Shenvi SV, McHugh TH, Olson DA, Ames BN. A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements. FASEB J. 2015 Aug; 29(8):3287-301. PMID: 25900806.
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    40. Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgözoglu L, Nordestgaard BG, Bruckert E, De Backer G, Krauss R, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, März W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J. 2015 May 01; 36(17):1012-22. PMID: 25694464; PMCID: PMC4416140.
    41. Brower MA, Jones MR, Rotter JI, Krauss R, Legro RS, Azziz R, Goodarzi MO. Further investigation in europeans of susceptibility variants for polycystic ovary syndrome discovered in genome-wide association studies of Chinese individuals. J Clin Endocrinol Metab. 2015 Jan; 100(1):E182-6. PMID: 25303487; PMCID: PMC4283012.
    42. Siri-Tarino PW, Chiu S, Bergeron N, Krauss R. Saturated Fats Versus Polyunsaturated Fats Versus Carbohydrates for Cardiovascular Disease Prevention and Treatment. Annu Rev Nutr. 2015; 35:517-43. PMID: 26185980; PMCID: PMC4744652.
    43. Iwuchukwu OF, Feng Q, Wei WQ, Jiang L, Jiang M, Xu H, Denny JC, Wilke RA, Krauss R, Roden DM, Stein CM. Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting. Pharmacogenomics. 2014 Nov; 15(14):1739-1747. PMID: 25493567.
      View in: PubMed
    44. Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJ, Stott DJ, Buckley BM, Ford I, Westendorp RG, Slagboom PE, Sattar N, Munroe PB, Sever P, Poulter N, Stanton A, Shields DC, O'Brien E, Shaw-Hawkins S, Chen YD, Nickerson DA, Smith JD, Dubé MP, Boekholdt SM, Hovingh GK, Kastelein JJ, McKeigue PM, Betteridge J, Neil A, Durrington PN, Doney A, Carr F, Morris A, McCarthy MI, Groop L, Ahlqvist E. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun. 2014 Oct 28; 5:5068. PMID: 25350695.
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    45. Krauss R, Pinto CA, Liu Y, Johnson-Levonas AO, Dansky HM. Changes in LDL particle concentrations after treatment with the cholesteryl ester transfer protein inhibitor anacetrapib alone or in combination with atorvastatin. J Clin Lipidol. 2015 Jan-Feb; 9(1):93-102. PMID: 25670366; PMCID: PMC4747335.
    46. Theusch E, Medina MW, Rotter JI, Krauss R. Ancestry and other genetic associations with plasma PCSK9 response to simvastatin. Pharmacogenet Genomics. 2014 Oct; 24(10):492-500. PMID: 25089948; PMCID: PMC4159722.
    47. Kitzmiller JP, Luzum JA, Baldassarre D, Krauss R, Medina MW. CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort. Pharmacogenet Genomics. 2014 Oct; 24(10):486-91. PMID: 25051018; PMCID: PMC4160394.
    48. Kim K, Bolotin E, Theusch E, Huang H, Medina MW, Krauss R. Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation. Genome Biol. 2014 Sep 30; 15(9):460. PMID: 25316374; PMCID: PMC4180544.
    49. Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T, Sofat R, Stender S, Johnson PC, Scott RA, Leusink M, Verweij N, Sharp SJ, Guo Y, Giambartolomei C, Chung C, Peasey A, Amuzu A, Li K, Palmen J, Howard P, Cooper JA, Drenos F, Li YR, Lowe G, Gallacher J, Stewart MC, Tzoulaki I, Buxbaum SG, van der A DL, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Stepaniak U, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Veglia F, Ford I, Jukema JW, Westendorp RG, de Borst GJ, de Jong PA, Algra A, Spiering W, Maitland-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Eaton CB, Robinson JG, Duggan D. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet. 2015 Jan 24; 385(9965):351-61. PMID: 25262344.
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    50. Mangravite LM, Engelhardt BE, Stephens M, Krauss R. Mangravite et al. reply. Nature. 2014 Sep 18; 513(7518):E3. PMID: 25230670.
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    51. Chiu S, Williams PT, Dawson T, Bergman RN, Stefanovski D, Watkins SM, Krauss R. Diets high in protein or saturated fat do not affect insulin sensitivity or plasma concentrations of lipids and lipoproteins in overweight and obese adults. J Nutr. 2014 Nov; 144(11):1753-9. PMID: 25332473; PMCID: PMC4195419.
    52. Medina MW, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H, Krauss R. Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1917-23. PMID: 25035345; PMCID: PMC4141484.
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    175. Mar R, Pajukanta P, Allayee H, Groenendijk M, Dallinga-Thie G, Krauss R, Sinsheimer JS, Cantor RM, de Bruin TW, Lusis AJ. Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia. Circ Res. 2004 Apr 16; 94(7):993-9. PMID: 15001527.
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    176. Farahani P, Chiu S, Bowlus CL, Boffelli D, Lee E, Fisler JS, Krauss R, Warden CH. Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptin. Obes Res. 2004 Feb; 12(2):191-204. PMID: 14981211.
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    177. Rizzo M, Taylor JM, Barbagallo CM, Berneis K, Blanche PJ, Krauss R. Effects on lipoprotein subclasses of combined expression of human hepatic lipase and human apoB in transgenic rabbits. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):141-6. PMID: 14615390.
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    178. Krauss R. Insulin resistance syndrome and dyslipidemia. Endocr Pract. 2003 Sep-Oct; 9 Suppl 2:67-72. PMID: 14698979.
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    179. Goodarzi MO, Guo X, Taylor KD, Quiñones MJ, Samayoa C, Yang H, Saad MF, Palotie A, Krauss R, Hsueh WA, Rotter JI. Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans. Genet Med. 2003 Jul-Aug; 5(4):322-7. PMID: 12865761.
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    180. Einhorn D, Reaven GM, Cobin RH, Ford E, Ganda OP, Handelsman Y, Hellman R, Jellinger PS, Kendall D, Krauss R, Neufeld ND, Petak SM, Rodbard HW, Seibel JA, Smith DA, Wilson PW. American College of Endocrinology position statement on the insulin resistance syndrome. Endocr Pract. 2003 May-Jun; 9(3):237-52. PMID: 12924350.
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    181. Williams PT, Superko HR, Haskell WL, Alderman EL, Blanche PJ, Holl LG, Krauss R. Smallest LDL particles are most strongly related to coronary disease progression in men. Arterioscler Thromb Vasc Biol. 2003 Feb 01; 23(2):314-21. PMID: 12588777.
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    182. Isaacsohn J, Hunninghake D, Schrott H, Dujovne CA, Knopp R, Weiss SR, Bays H, Crouse JR, Davidson MH, Keilson LM, McKenney J, Korenman SG, Dobs AS, Stein E, Krauss R, Maccubbin D, Cho M, Plotkin DJ, Mitchel YB. Effects of simvastatin, an HMG-CoA reductase inhibitor, in patients with hypertriglyceridemia. Clin Cardiol. 2003 Jan; 26(1):18-24. PMID: 12539808.
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    183. Pennacchio LA, Olivier M, Hubacek JA, Krauss R, Rubin EM, Cohen JC. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet. 2002 Nov 15; 11(24):3031-8. PMID: 12417524.
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    184. Olin-Lewis K, Krauss R, La Belle M, Blanche PJ, Barrett PH, Wight TN, Chait A. ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan. J Lipid Res. 2002 Nov; 43(11):1969-77. PMID: 12401896.
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    185. Attie AD, Krauss R, Gray-Keller MP, Brownlie A, Miyazaki M, Kastelein JJ, Lusis AJ, Stalenhoef AF, Stoehr JP, Hayden MR, Ntambi JM. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res. 2002 Nov; 43(11):1899-907. PMID: 12401889.
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    186. Berneis KK, Krauss R. Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res. 2002 Sep; 43(9):1363-79. PMID: 12235168.
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    187. Sattler FR, Schroeder ET, Dube MP, Jaque SV, Martinez C, Blanche PJ, Azen S, Krauss R. Metabolic effects of nandrolone decanoate and resistance training in men with HIV. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1214-22. PMID: 12388173.
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    188. Berneis K, La Belle M, Blanche PJ, Krauss R. Analysis and quantitation of biotinylated apoB-containing lipoproteins with streptavidin-Cy3. J Lipid Res. 2002 Jul; 43(7):1155-9. PMID: 12091501.
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    189. Krauss R. Individualized hormone-replacement therapy? N Engl J Med. 2002 Mar 28; 346(13):1017-8. PMID: 11919312.
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    190. Campos E, Kotite L, Blanche P, Mitsugi Y, Frost PH, Masharani U, Krauss R, Havel RJ. Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma. J Lipid Res. 2002 Mar; 43(3):365-74. PMID: 11893772.
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    191. Forte TM, Subbanagounder G, Berliner JA, Blanche PJ, Clermont AO, Jia Z, Oda MN, Krauss R, Bielicki JK. Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice. J Lipid Res. 2002 Mar; 43(3):477-85. PMID: 11893784.
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    192. Krauss R. Is the size of low-density lipoprotein particles related to the risk of coronary heart disease? JAMA. 2002 Feb 13; 287(6):712-3. PMID: 11851524.
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