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PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma. Cancer Research. 2023.
Mondal I, Das O, Sun R, Gao J, Yu B, Diaz A, Behnan J, Dubey A, Meng Z, Eskandar E, Xu B, Lu R*, and Ho W* corresponding author.
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PP2A/STRN4 Negatively Regulates STING-Type I Interferon Signaling in Tumor Associated Macrophages. Journal of Clinical Investigation. 2023.
Ho WS*, Mondal I*, Xu B*, Das O*, Sun R, Chiou P, Lyu J, Li L, Cai X, Tahmasebinia F, Wu C Y-J, Wu Z, Matsui W, Lim M, Meng Z, Lu RO* corresponding author.
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Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism. Nat Commun. 2022 05 03; 13(1):2412.
Huang Y, Wan Z, Tang Y, Xu J, Laboret B, Nallamothu S, Yang C, Liu B, Lu RO, Lu RO, Lu B, Feng J, Cao J, Hayflick S, Wu Z, Zhou B. PMID: 35504872; PMCID: PMC9065001.
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9 Fields:
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AnimalsCells
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Targeting Mitochondrial Oxidative Phosphorylation in Glioblastoma Therapy. Neuromolecular Med. 2022 03; 24(1):18-22.
Wu Z, Ho WS, Lu R. PMID: 34487301.
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14 Fields:
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HumansCells
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Mitochondrial Dysfunction, Macrophage, and Microglia in Brain Cancer. Front Cell Dev Biol. 2020; 8:620788.
Lu RO, Ho WS. PMID: 33520994; PMCID: PMC7843701.
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9
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Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma. J Neurooncol. 2020; 2(148):231-244.
Maggio D, Ho WS, Breese R, Walbridge S, Wang H, Cui J, Heiss JD, Gilbert MR, Kovach JS, Lu RO*, Zhuang Z. corresponding author.
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Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade. Nat Commun. 2019; 1(9):2126.
Ho WS, Wang H, Maggio D, Kovach JS, Zhang Q, Song Q, Marincola FM, Heiss JD, Gilbert MR, Lu R* corresponding author.
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Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. J Immunother Cancer. 2019 05 22; 7(1):131.
Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Group. PMID: 31113486; PMCID: PMC6529999.
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46 Fields:
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HumansAnimals
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Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA). J Immunother Cancer. 2018 06 22; 6(1):63.
Danaher P, Warren S, Lu R, Samayoa J, Sullivan A, Pekker I, Wallden B, Marincola FM, Cesano A. PMID: 29929551; PMCID: PMC6013904.
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210 Fields:
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HumansCells
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Immune oncology, immune responsiveness and the theory of everything. J Immunother Cancer. 2018 06 05; 6(1):50.
Turan T, Kannan D, Patel M, Matthew Barnes J, Tanlimco SG, Lu R, Halliwill K, Kongpachith S, Kline DE, Hendrickx W, Cesano A, Butterfield LH, Kaufman HL, Hudson TJ, Bedognetti D, Marincola F, Samayoa J. PMID: 29871670; PMCID: PMC5989400.
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39 Fields:
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Humans
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Cancer immune resistance: can theories converge? Emerg Top Life Sci. 2017 Dec 12; 1(5):411-419.
Lu R, Turan T, Samayoa J, Marincola FM. PMID: 33525800; PMCID: PMC7289003.
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9 Fields:
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LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation. Cancer Lett. 2018 02 28; 415:217-226.
Ho WS, Sizdahkhani S, Hao S, Song H, Seldomridge A, Tandle A, Maric D, Kramp T, Lu R, Heiss JD, Camphausen K, Gilbert MR, Zhuang Z, Park DM. PMID: 29199006; PMCID: PMC5748254.
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22 Fields:
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HumansAnimalsCells
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Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015 Feb 19; 518(7539):417-21.
Rutz S, Kayagaki N, Phung QT, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang OW, Cochran AG, Vasser M, Fauber BP, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick DS, Lill JR, Ouyang W, Dixit VM. PMID: 25470037.
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74 Fields:
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AnimalsCells
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NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. Nature. 2014 May 08; 509(7499):235-9.
Noubade R, Wong K, Ota N, Rutz S, Eidenschenk C, Valdez PA, Ding J, Peng I, Sebrell A, Caplazi P, DeVoss J, Soriano RH, Sai T, Lu R, Modrusan Z, Hackney J, Ouyang W. PMID: 24739962.
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106 Fields:
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AnimalsCells
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G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells. J Biol Chem. 2013 May 10; 288(19):13842-9.
Xin H, Lu R, Lee H, Zhang W, Zhang C, Deng J, Liu Y, Shen S, Wagner KU, Forman S, Jove R, Yu H. PMID: 23548897; PMCID: PMC3650420.
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32 Fields:
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HumansAnimalsCells
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CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog. 2012; 8(4):e1002597.
Lu R, Pan H, Shively JE. PMID: 22496641; PMCID: PMC3320586.
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44 Fields:
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AnimalsCells
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Tumor angiogenesis mediated by myeloid cells is negatively regulated by CEACAM1. Cancer Res. 2012 May 01; 72(9):2239-50.
Lu R, Kujawski M, Pan H, Shively JE. PMID: 22406619; PMCID: PMC3765079.
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21 Fields:
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AnimalsCells
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Interaction of actin with carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) receptor in liposomes is Ca2+- and phospholipid-dependent. J Biol Chem. 2011 Aug 05; 286(31):27528-36.
Lu R, Niesen MJ, Hu W, Vaidehi N, Shively JE. PMID: 21669871; PMCID: PMC3149345.
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7 Fields:
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Cells