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Russell Pieper, PhD

Title(s)Professor, Neurological Surgery
SchoolSchool of Medicine
Address1450 3rd Street
San Francisco CA 94158
Phone415-502-7132
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of Wisconsin, Madison, WIBS1982Pharmacy
    The George Washington Univeristy, Washington, DCPhD1987Pharmacology

    Collapse Overview 
    Collapse Overview
    Russ Pieper, PhD is a lab-based investigator in the UCSF Brain Tumor Center. He received a BS degree in Pharmacy from the University of Wisconsin and a PhD degree in Pharmacology from The George Washington University in Washington, DC, followed by postdoctoral training and a faculty position at Loyola University-Chicago. He is currently the Neill H. and Linda S. Brownstein Chair in Brain Tumor Research and Professor and Vice-Chairman of the UCSF Department of Neurological Surgery. He is also Director of Basic Research in the UCSF Brain Tumor Research Center and co-Leader of the Neuro-Oncology Program in the Helen Diller Family Comprehensive Cancer Center. His research has been independently funded by the National Institutes of Health and the National Cancer Institute since 1989 and is focused on the role signal transduction plays in the development and therapy of brain tumors. The laboratory is currently focused on how mutant IDH1 expression regulates telomere biology and contributes to the development of lower-grade glioma.

    Collapse Research 
    Collapse Research Activities and Funding
    Contributions of IDH1 mutation to alternative lengthening of telomeres in lower-grade glioma
    NIH/NINDS R01NS105087Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Understanding the role of altered metabolism in gliomagenesis
    NIH/NCI R01CA171610Feb 1, 2013 - Jan 31, 2018
    Role: Principal Investigator
    Training Program in Translational Brain Tumor Research
    NIH/NCI T32CA151022Sep 1, 2010 - Aug 31, 2020
    Role: Co-Principal Investigator
    Imaging and Tissue Correlates to Optimize Management of Glioblastoma
    NIH/NCI P01CA118816Aug 1, 2009 - Jun 30, 2013
    Role: Co-Investigator
    A PTEN-regulated ubiquitin switch controlling TRAIL sensitivity in GBM
    NIH/NCI R01CA136774Jul 1, 2009 - Apr 30, 2014
    Role: Principal Investigator
    UNDERSTANDING TRAIL SENSITIVITY IN HUMAN GLIOMA
    NIH/NCI R01CA115638Jun 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    P38, G2 Arrest, and Temozolomide Resistance in Gliomas
    NIH/NCI R01CA100011Feb 1, 2004 - Jan 31, 2010
    Role: Principal Investigator
    Brain Tumor SPORE Grant
    NIH/NCI P50CA097257Sep 20, 2002 - Aug 31, 2023
    Role: Co-Investigator
    Contributions of Akt to Glioblastoma Formation
    NIH/NCI R01CA094989Apr 1, 2002 - Mar 31, 2007
    Role: Principal Investigator
    TRIGGERING OF ABERRANT CPG ISLAND METHYLATION
    NIH/NCI R01CA085352Jul 1, 2000 - Jun 30, 2003
    Role: Principal Investigator
    EXPRESSION AND SILENCING OF CPG ISLAND-CONTAINING GENES
    NIH/NCI R01CA079496Mar 1, 1999 - Feb 28, 2002
    Role: Principal Investigator
    CHROMATIN STRUCTURE AND CONTROL
    NIH/NCI R01CA055064Aug 1, 1997 - Jun 30, 2000
    Role: Principal Investigator
    ALKYLTRANSFERASE STRUCTURE AND FUNCTION
    NIH/NCI R01CA062389Jul 1, 1994 - Jun 30, 1998
    Role: Principal Investigator
    ALKYLTRANSFERASE EXPRESSION/DNA METHYLATION
    NIH/NCI R29CA055064Jul 1, 1991 - Jun 30, 1997
    Role: Principal Investigator
    CONSEQUENCES OF SELECTIVE INDUCTION OF DNA CROSSLINKS
    NIH/NCI F32CA008685Sep 22, 1990
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity. Cell Rep. 2020 Apr 14; 31(2):107518. Ohba S, Johannessen TA, Chatla K, Yang X, Pieper RO, Mukherjee J. PMID: 32294440.
      View in: PubMed   Mentions:    Fields:    
    2. The Correlation of Fluorescence of Protoporphyrinogen IX and Status of Isocitrate Dehydrogenase in Gliomas. Neurosurgery. 2019 Dec 13. Ohba S, Murayama K, Kuwahara K, Pareira ES, Nakae S, Nishiyama Y, Adachi K, Yamada S, Sasaki H, Yamamoto N, Abe M, Mukherjee J, Hasegawa M, Pieper RO, Hirose Y. PMID: 31833548.
      View in: PubMed   Mentions:    Fields:    
    3. PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival. Sci Rep. 2019 07 19; 9(1):10521. Batsios G, Viswanath P, Subramani E, Najac C, Gillespie AM, Santos RD, Molloy AR, Pieper RO, Ronen SM. PMID: 31324855.
      View in: PubMed   Mentions:    Fields:    
    4. Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer. Cancer Discov. 2019 06; 9(6):756-777. Chen D, Xia S, Wang M, Lin R, Li Y, Mao H, Aguiar M, Famulare CA, Shih AH, Brennan CW, Gao X, Pan Y, Liu S, Fan J, Jin L, Song L, Zhou A, Mukherjee J, Pieper RO, Mishra A, Peng J, Arellano M, Blum WG, Lonial S, Boggon TJ, Levine RL, Chen J. PMID: 30862724.
      View in: PubMed   Mentions:    Fields:    
    5. HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI. NMR Biomed. 2019 02; 32(2):e4044. Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM. PMID: 30561869.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Neurofibromin knockdown in glioma cell lines is associated with changes in cytokine and chemokine secretion in vitro. Sci Rep. 2018 04 11; 8(1):5805. Wood MD, Mukherjee J, Pieper RO. PMID: 29643433.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner. Cancer Metab. 2018; 6:3. Viswanath P, Radoul M, Izquierdo-Garcia JL, Luchman HA, Gregory Cairncross J, Pieper RO, Phillips JJ, Ronen SM. PMID: 29619216.
      View in: PubMed   Mentions:
    8. Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma. Cancer Res. 2018 06 01; 78(11):2966-2977. Mukherjee J, Johannessen TC, Ohba S, Chow TT, Jones L, Pandita A, Pieper RO. PMID: 29545335.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. 2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas. Cancer Res. 2018 05 01; 78(9):2290-2304. Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM. PMID: 29358170.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process. Cancer Res. 2016 11 15; 76(22):6680-6689. Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO. PMID: 27758882.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy. Oncogene. 2017 02 23; 36(8):1145-1156. Hu L, Li X, Liu Q, Xu J, Ge H, Wang Z, Wang H, Wang Z, Shi C, Xu X, Huang J, Lin Z, Pieper RO, Weng C. PMID: 27593939.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis. Mol Cancer Res. 2016 10; 14(10):976-983. Johannessen TA, Mukherjee J, Viswanath P, Ohba S, Ronen SM, Bjerkvig R, Pieper RO. PMID: 27430238.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    13. Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters. Oncotarget. 2016 Jun 07; 7(23):34942-55. Viswanath P, Najac C, Izquierdo-Garcia JL, Pankov A, Hong C, Eriksson P, Costello JF, Pieper RO, Ronen SM. PMID: 27144334.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. Int J Cancer. 2016 Jul 01; 139(1):99-111. Mukherjee J, Ohba S, See WL, Phillips JJ, Molinaro AM, Pieper RO. PMID: 26874904.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer Res. 2015 Aug 01; 75(15):2999-3009. Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM. PMID: 26045167.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    16. Metabolic reprogramming in mutant IDH1 glioma cells. PLoS One. 2015; 10(2):e0118781. Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips JJ, Ronen SM. PMID: 25706986.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    17. Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res. 2014 Dec 01; 74(23):7115-24. Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO. PMID: 25320009.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    18. Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase. PLoS One. 2014; 9(9):e108289. Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM. PMID: 25243911.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    19. Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance. Cancer Res. 2014 Sep 01; 74(17):4836-44. Ohba S, Mukherjee J, See WL, Pieper RO. PMID: 25035396.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    20. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res. 2014 Aug 15; 74(16):4247-57. Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. PMID: 24876103.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    21. Lactate dehydrogenase A silencing in IDH mutant gliomas. Neuro Oncol. 2014 May; 16(5):686-95. Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG. PMID: 24366912.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    22. Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage. PLoS One. 2013; 8(5):e62351. Ito M, Ohba S, Gaensler K, Ronen SM, Mukherjee J, Pieper RO. PMID: 23667469.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma. PLoS One. 2013; 8(2):e57610. Mukherjee J, Phillips JJ, Zheng S, Wiencke J, Ronen SM, Pieper RO. PMID: 23451252.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    24. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4:2429. Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. PMID: 24019001.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    25. Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging. Magn Reson Med. 2013 Jul; 70(1):33-9. Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ. PMID: 22851374.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    26. Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla. Neuro Oncol. 2012 Aug; 14(8):1050-61. Chaumeil MM, Gini B, Yang H, Iwanami A, Sukumar S, Ozawa T, Pieper RO, Mischel PS, James CD, Berger MS, Ronen SM. PMID: 22670012.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    27. Sensitivity of glioblastomas to clinically available MEK inhibitors is defined by neurofibromin 1 deficiency. Cancer Res. 2012 Jul 01; 72(13):3350-9. See WL, Tan IL, Mukherjee J, Nicolaides T, Pieper RO. PMID: 22573716.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    28. Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. Neuro Oncol. 2011 Dec; 13(12):1331-8. Butowski N, Chang SM, Lamborn KR, Polley MY, Pieper R, Costello JF, Vandenberg S, Parvataneni R, Nicole A, Sneed PK, Clarke J, Hsieh E, Costa BM, Reis RM, Hristova-Kazmierski M, Nicol SJ, Thornton DE, Prados MD. PMID: 21896554.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCellsCTClinical Trials
    29. NPAS3 demonstrates features of a tumor suppressive role in driving the progression of Astrocytomas. Am J Pathol. 2011 Jul; 179(1):462-76. Moreira F, Kiehl TR, So K, Ajeawung NF, Honculada C, Gould P, Pieper RO, Kamnasaran D. PMID: 21703424.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    30. Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity. PLoS One. 2011; 6(5):e19629. Wang D, Olman MA, Stewart J, Tipps R, Huang P, Sanders PW, Toline E, Prayson RA, Lee J, Weil RJ, Palmer CA, Gillespie GY, Liu WM, Pieper RO, Guan JL, Gladson CL. PMID: 21602932.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    31. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 01; 71(1):106-15. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. PMID: 21199799.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    32. Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma. J Clin Neurosci. 2010 Dec; 17(12):1543-7. Waldron JS, Yang I, Han S, Tihan T, Sughrue ME, Mills SA, Pieper RO, Parsa AT. PMID: 20822910.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    33. Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Res. 2010 Jun 15; 70(12):5046-53. Panner A, Crane CA, Weng C, Feletti A, Fang S, Parsa AT, Pieper RO. PMID: 20484045.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    34. FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Res. 2010 Apr 01; 70(7):2951-61. Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, Sawaya R, Xie K, Huang S. PMID: 20332230.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    35. Gamma interferon-mediated superinduction of B7-H1 in PTEN-deficient glioblastoma: a paradoxical mechanism of immune evasion. Neuroreport. 2009 Dec 09; 20(18):1597-602. Han SJ, Ahn BJ, Waldron JS, Yang I, Fang S, Crane CA, Pieper RO, Parsa AT. PMID: 19875977.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    36. A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Res. 2009 Oct 15; 69(20):7911-6. Panner A, Crane CA, Weng C, Feletti A, Parsa AT, Pieper RO. PMID: 19808964.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    37. Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function. J Immunother. 2009 Jul-Aug; 32(6):585-92. Crane C, Panner A, Pieper RO, Arbiser J, Parsa AT. PMID: 19483651.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    38. The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma. Cancer Res. 2009 Apr 01; 69(7):2809-16. Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA. PMID: 19339267.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    39. p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. Cancer Res. 2008 Dec 15; 68(24):10034-9. Dinca EB, Lu KV, Sarkaria JN, Pieper RO, Prados MD, Haas-Kogan DA, Vandenberg SR, Berger MS, James CD. PMID: 19074867.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    40. PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. Oncogene. 2009 Jan 15; 28(2):306-12. Crane CA, Panner A, Murray JC, Wilson SP, Xu H, Chen L, Simko JP, Waldman FM, Pieper RO, Parsa AT. PMID: 18850006.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    41. S6K1 plays a key role in glial transformation. Cancer Res. 2008 Aug 15; 68(16):6516-23. Nakamura JL, Garcia E, Pieper RO. PMID: 18701474.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    42. H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway. Glia. 2008 Jun; 56(8):917-24. Zhao Y, Xiao A, Dipierro CG, Abdel-Fattah R, Amos S, Redpath GT, Carpenter JE, Pieper RO, Hussaini IM. PMID: 18383343.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    43. Notch activation is associated with tetraploidy and enhanced chromosomal instability in meningiomas. Neoplasia. 2008 Jun; 10(6):604-12. Baia GS, Stifani S, Kimura ET, McDermott MW, Pieper RO, Lal A. PMID: 18516297.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    44. Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation. J Neurosurg. 2008 Feb; 108(2):299-303. Chi JH, Panner A, Cachola K, Crane CA, Murray J, Pieper RO, James CD, Parsa AT. PMID: 18240926.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    45. Glioma invasiveness responds variably to irradiation in a co-culture model. Int J Radiat Oncol Biol Phys. 2007 Nov 01; 69(3):880-6. Nakamura JL, Haas-Kogan DA, Pieper RO. PMID: 17889268.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    46. Heat shock protein 90alpha recruits FLIPS to the death-inducing signaling complex and contributes to TRAIL resistance in human glioma. Cancer Res. 2007 Oct 01; 67(19):9482-9. Panner A, Murray JC, Berger MS, Pieper RO. PMID: 17909058.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    47. Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasiveness. J Neurooncol. 2007 Dec; 85(3):271-80. Cobbs CS, Soroceanu L, Denham S, Zhang W, Britt WJ, Pieper R, Kraus MH. PMID: 17589804.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    48. Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg. 2007 Mar; 106(3):417-27. Kanamori M, Kawaguchi T, Nigro JM, Feuerstein BG, Berger MS, Miele L, Pieper RO. PMID: 17367064.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    49. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat Med. 2007 Jan; 13(1):84-8. Parsa AT, Waldron JS, Panner A, Crane CA, Parney IF, Barry JJ, Cachola KE, Murray JC, Tihan T, Jensen MC, Mischel PS, Stokoe D, Pieper RO. PMID: 17159987.
      View in: PubMed   Mentions: 418     Fields:    Translation:HumansCells
    50. The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer Res. 2006 Dec 01; 66(23):11331-40. Kawaguchi T, Yamashita Y, Kanamori M, Endersby R, Bankiewicz KS, Baker SJ, Bergers G, Pieper RO. PMID: 17145879.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    51. Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med. 2006 Dec; 3(12):e485. Lee JC, Vivanco I, Beroukhim R, Huang JH, Feng WL, DeBiasi RM, Yoshimoto K, King JC, Nghiemphu P, Yuza Y, Xu Q, Greulich H, Thomas RK, Paez JG, Peck TC, Linhart DJ, Glatt KA, Getz G, Onofrio R, Ziaugra L, Levine RL, Gabriel S, Kawaguchi T, O'Neill K, Khan H, Liau LM, Nelson SF, Rao PN, Mischel P, Pieper RO, Cloughesy T, Leahy DJ, Sellers WR, Sawyers CL, Meyerson M, Mellinghoff IK. PMID: 17177598.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    52. The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity. Mol Cancer Ther. 2006 Nov; 5(11):2757-66. Mirzoeva OK, Kawaguchi T, Pieper RO. PMID: 17121922.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    53. Intracranial microenvironment reveals independent opposing functions of host alphaVbeta3 expression on glioma growth and angiogenesis. J Biol Chem. 2006 Dec 01; 281(48):37256-64. Kanamori M, Kawaguchi T, Berger MS, Pieper RO. PMID: 17028191.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    54. Use of APO2L/TRAIL with mTOR inhibitors in the treatment of glioblastoma multiforme. Expert Rev Anticancer Ther. 2006 Sep; 6(9):1313-22. Panner A, Parsa AT, Pieper RO. PMID: 17020463.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    55. DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ. 2007 Mar; 14(3):548-58. Katayama M, Kawaguchi T, Berger MS, Pieper RO. PMID: 16946731.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    56. mTOR-independent translational control of the extrinsic cell death pathway by RalA. Mol Cell Biol. 2006 Oct; 26(20):7345-57. Panner A, Nakamura JL, Parsa AT, Rodriguez-Viciana P, Berger MS, Stokoe D, Pieper RO. PMID: 16894031.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    57. Translational regulation of TRAIL sensitivity. Cell Cycle. 2006 Jan; 5(2):147-50. Panner A, Parsa AT, Pieper RO. PMID: 16397410.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    58. mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol Cell Biol. 2005 Oct; 25(20):8809-23. Panner A, James CD, Berger MS, Pieper RO. PMID: 16199861.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    59. Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence. Cancer Res. 2005 Jun 01; 65(11):4861-9. Hirose Y, Katayama M, Mirzoeva OK, Berger MS, Pieper RO. PMID: 15930307.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    60. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res. 2005 Feb 15; 65(4):1406-13. Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG, Brat DJ. PMID: 15735028.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    61. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. J Neurooncol. 2005 Feb; 71(3):215-22. Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper RO, Stokoe D, Haas-Kogan DA. PMID: 15735908.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    62. Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft model. Cancer Res. 2004 Oct 01; 64(19):6858-62. Saito R, Bringas JR, Panner A, Tamas M, Pieper RO, Berger MS, Bankiewicz KS. PMID: 15466173.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    63. Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide. J Neurosurg. 2004 Jun; 100(6):1060-5. Hirose Y, Katayama M, Berger MS, Pieper RO. PMID: 15200121.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    64. Integrin beta3 overexpression suppresses tumor growth in a human model of gliomagenesis: implications for the role of beta3 overexpression in glioblastoma multiforme. Cancer Res. 2004 Apr 15; 64(8):2751-8. Kanamori M, Vanden Berg SR, Bergers G, Berger MS, Pieper RO. PMID: 15087390.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    65. The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol Cell Biol. 2003 Nov; 23(22):8306-15. Hirose Y, Katayama M, Stokoe D, Haas-Kogan DA, Berger MS, Pieper RO. PMID: 14585987.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    66. Overexpression of vascular endothelial growth factor isoforms drives oxygenation and growth but not progression to glioblastoma multiforme in a human model of gliomagenesis. Cancer Res. 2003 Apr 15; 63(8):1962-8. Sonoda Y, Kanamori M, Deen DF, Cheng SY, Berger MS, Pieper RO. PMID: 12702589.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    67. Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity. J Neurosurg. 2003 Mar; 98(3):591-8. Hirose Y, Kreklau EL, Erickson LC, Berger MS, Pieper RO. PMID: 12650433.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    68. Defined human cellular systems in the study of glioma development. Front Biosci. 2003 Jan 01; 8:s19-27. Pieper RO. PMID: 12456369.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    69. Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res. 2001 Sep 15; 61(18):6674-8. Sonoda Y, Ozawa T, Aldape KD, Deen DF, Berger MS, Pieper RO. PMID: 11559533.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    70. Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res. 2001 Aug 01; 61(15):5843-9. Hirose Y, Berger MS, Pieper RO. PMID: 11479224.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    71. Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Res. 2001 Jul 01; 61(13):4956-60. Sonoda Y, Ozawa T, Hirose Y, Aldape KD, McMahon M, Berger MS, Pieper RO. PMID: 11431323.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    72. Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation. J Biol Chem. 2001 Jun 01; 276(22):18871-7. Fanton CP, McMahon M, Pieper RO. PMID: 11278920.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    73. p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells. Cancer Res. 2001 Mar 01; 61(5):1957-63. Hirose Y, Berger MS, Pieper RO. PMID: 11280752.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    74. Highly efficient cell-mediated gene transfer using non-viral vectors and FuGene6: in vitro and in vivo studies. Cell Mol Life Sci. 2000 Aug; 57(8-9):1326-33. Hellgren I, Drvota V, Pieper R, Enoksson S, Blomberg P, Islam KB, Sylvén C. PMID: 11028922.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    75. Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells. Neuro Oncol. 2000 07; 2(3):174-83. Chang GH, Barbaro NM, Pieper RO. PMID: 11302338.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    76. Presetting of chromatin structure and transcription factor binding poise the human GADD45 gene for rapid transcriptional up-regulation. Nucleic Acids Res. 1999 Oct 01; 27(19):3881-90. Graunke DM, Fornace AJ, Pieper RO. PMID: 10481028.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    77. Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts. Nucleic Acids Res. 1999 Aug 01; 27(15):3229-35. Pieper RO, Lester KA, Fanton CP. PMID: 10454622.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    78. Aberrant silencing of the CpG island-containing human O6-methylguanine DNA methyltransferase gene is associated with the loss of nucleosome-like positioning. Mol Cell Biol. 1997 Oct; 17(10):5813-22. Patel SA, Graunke DM, Pieper RO. PMID: 9315639.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    79. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol. 1997 Sep; 17(9):5612-9. Watts GS, Pieper RO, Costello JF, Peng YM, Dalton WS, Futscher BW. PMID: 9271436.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    80. Understanding and manipulating O6-methylguanine-DNA methyltransferase expression. Pharmacol Ther. 1997; 74(3):285-97. Pieper RO. PMID: 9352585.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    81. Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene. J Biol Chem. 1996 Jun 07; 271(23):13916-24. Pieper RO, Patel S, Ting SA, Futscher BW, Costello JF. PMID: 8662860.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    82. In vitro transcription termination by N,N'-bis(2-chloroethyl)-N-nitrosourea-induced DNA lesions. Mol Pharmacol. 1995 Feb; 47(2):290-5. Pieper RO, Noftz SL, Erickson LC. PMID: 7870037.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    83. Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines. Mol Cell Biol. 1994 Oct; 14(10):6515-21. Costello JF, Futscher BW, Kroes RA, Pieper RO. PMID: 7523853.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    84. The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificity. Carcinogenesis. 1994 Sep; 15(9):1895-902. Pieper RO, Morgan SE, Kelley MR. PMID: 7923583.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    85. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J Biol Chem. 1994 Jun 24; 269(25):17228-37. Costello JF, Futscher BW, Tano K, Graunke DM, Pieper RO. PMID: 8006031.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    86. The role of the carboxyl-terminal tail in human O6-methylguanine DNA methyltransferase substrate specificity and temperature sensitivity. J Biol Chem. 1993 Sep 15; 268(26):19802-9. Morgan SE, Kelley MR, Pieper RO. PMID: 8366118.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    87. DNA-damaging and transcription-terminating lesions induced by AF64A in vitro. J Neurochem. 1992 Apr; 58(4):1504-9. Futscher BW, Pieper RO, Barnes DM, Hanin I, Erickson LC. PMID: 1548483.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    88. Gene-specific DNA interstrand cross-links produced by nitrogen mustard in the human tumor cell line Colo320HSR. Cell Growth Differ. 1992 Apr; 3(4):217-23. Futscher BW, Pieper RO, Dalton WS, Erickson LC. PMID: 1515367.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    89. Expression of ribosomal phosphoprotein PO is induced by antitumor agents and increased in Mer- human tumor cell lines. Carcinogenesis. 1992 Feb; 13(2):259-63. Grabowski DT, Pieper RO, Futscher BW, Deutsch WA, Erickson LC, Kelley MR. PMID: 1740017.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    90. Direct correlation between methylation status and expression of the human O-6-methylguanine DNA methyltransferase gene. Cancer Commun. 1991 Aug; 3(8):241-53. Pieper RO, Costello JF, Kroes RA, Futscher BW, Marathi U, Erickson LC. PMID: 1716139.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    91. Effects of streptozotocin/bis-chloroethylnitrosourea combination therapy on O6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro. Cancer Res. 1991 Mar 15; 51(6):1581-5. Pieper RO, Futscher BW, Dong Q, Erickson LC. PMID: 1825618.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    92. DNA adenine adducts induced by nitrogen mustards and their role in transcription termination in vitro. Carcinogenesis. 1990 Oct; 11(10):1739-46. Pieper RO, Erickson LC. PMID: 2208589.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    93. Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique. Cancer Commun. 1990; 2(1):13-20. Pieper RO, Futscher BW, Dong Q, Ellis TM, Erickson LC. PMID: 2369549.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    94. Transcription-terminating lesions induced by bifunctional alkylating agents in vitro. Carcinogenesis. 1989 Jul; 10(7):1307-14. Pieper RO, Futscher BW, Erickson LC. PMID: 2736721.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    95. Interrelationship of 3-deazaguanine-induced growth inhibitory actions in L1210 cells. Biochem Pharmacol. 1988 Sep 15; 37(18):3534-7. Pieper RO, Mandel HG. PMID: 3422001.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    96. Gastric cancer. Factors influencing longterm survival and postoperative mortality. Acta Chir Scand Suppl. 1986; 530:25-9. Sjöstedt S, Pieper R. PMID: 2425528.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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