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Ruth Huettenhain, PhD

Title(s)Assistant Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address1700 4th St
San Francisco CA 94158
Phone415-476-3068
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    Collapse Biography 
    Collapse Education and Training
    UCSF, San Francisco, CAPostdoctoral Scholar2018Systems Biology
    ETH Zurich, Zurich, SwitzerlandPostdoctoral Scholar2013Systems Biology
    ETH Zurich, Zurich, SwitzerlandPhD, Doctor of Sciences in Systems Biology2011Systems Biology
    University of Bonn, Bonn, GermanyPharmD2006
    Collapse Awards and Honors
    Human Proteome Organization2018HUPO Early Career Scientist Award
    Swiss National Science Foundation2015  - 2016Advanced Postdoc Mobility Fellowship
    Human Frontiers Science Program (HFSP)2014  - 2018Long-Term Postdoctoral Fellowship
    European Molecular Biology Organization (EMBO)2014  - 2015Long-Term Postdoctoral Fellowship
    UCSF, San Francisco, CA2014  - 2015CFAR Basic Science Award in HIV/AIDS
    Swiss National Science Foundation2013  - 2014Early Postdoc Mobility Fellowship
    ETH Zurich, Switzerland2013ETH medal for outstanding dissertation
    Human Proteome Organization20122nd prize for young investigators in clinical proteomics
    Human Proteome Organization2011Finalist for the EUPA Young Investigator Award in proteomics
    Swiss Proteomics Society Meeting 2009, Zurich, Switzerland2009Poster prize (Category: Biomarkers)
    EMBO Cancer Proteomics 20092009Travel award
    Swiss Proteomics Society Meeting 2007, Lausanne, Switzerland 20071st Poster prize

    Collapse ORNG Applications 
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    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Jun 28. Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero D, Zhou Y, Dugourd A, Valdeolivas A, Patil T, Li Q, Hüttenhain R, Cakir M, Muralidharan M, Kim M, Jang G, Tutuncuoglu B, Hiatt J, Guo JZ, Xu J, Bouhaddou S, Mathy CJP, Gaulton A, Manners EJ, Félix E, Shi Y, Goff M, Lim JK, McBride T, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, De Wit E, Leach AR, Kortemme T, Shoichet B, Ott M, Saez-Rodriguez J, tenOever BR, Mullins RD, Fischer ER, Kochs G, Grosse R, García-Sastre A, Vignuzzi M, Johnson JR, Shokat KM, Swaney DL, Beltrao P, Krogan NJ. PMID: 32645325.
      View in: PubMed   Mentions: 1     Fields:    
    2. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Apr 30. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    3. A systems approach to infectious disease. Nat Rev Genet. 2020 Jun; 21(6):339-354. Eckhardt M, Hultquist JF, Kaake RM, Hüttenhain R, Krogan NJ. PMID: 32060427.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Enterovirus pathogenesis requires the host methyltransferase SETD3. Nat Microbiol. 2019 12; 4(12):2523-2537. Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE. PMID: 31527793.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. A Targeted Mass Spectrometry Strategy for Developing Proteomic Biomarkers: A Case Study of Epithelial Ovarian Cancer. Mol Cell Proteomics. 2019 09; 18(9):1836-1850. Hüttenhain R, Choi M, Martin de la Fuente L, Oehl K, Chang CV, Zimmermann AK, Malander S, Olsson H, Surinova S, Clough T, Heinzelmann-Schwarz V, Wild PJ, Dinulescu DM, Niméus E, Vitek O, Aebersold R. PMID: 31289117.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    6. ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host Microbe. 2019 07 10; 26(1):86-99.e7. Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ. PMID: 31253590.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Cell. 2018 12 13; 175(7):1931-1945.e18. Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ. PMID: 30550790.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    8. CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18). Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. PMID: 30166453.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS. Cell Rep. 2018 05 29; 23(9):2819-2831.e5. Sajic T, Liu Y, Arvaniti E, Surinova S, Williams EG, Schiess R, Hüttenhain R, Sethi A, Pan S, Brentnall TA, Chen R, Blattmann P, Friedrich B, Niméus E, Malander S, Omlin A, Gillessen S, Claassen M, Aebersold R. PMID: 29847809.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell. 2017 04 06; 169(2):350-360.e12. Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ. PMID: 28388416.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    12. Prediction of colorectal cancer diagnosis based on circulating plasma proteins. EMBO Mol Med. 2015 Sep; 7(9):1166-78. Surinova S, Choi M, Tao S, Schüffler PJ, Chang CY, Clough T, Vysloužil K, Khoylou M, Srovnal J, Liu Y, Matondo M, Hüttenhain R, Weisser H, Buhmann JM, Hajdúch M, Brenner H, Vitek O, Aebersold R. PMID: 26253081.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    13. Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics. 2014 Mar; 13(3):907-17. Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S. PMID: 24443746.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimals
    14. Mass spectrometric protein maps for biomarker discovery and clinical research. Expert Rev Mol Diagn. 2013 Nov; 13(8):811-25. Liu Y, Hüttenhain R, Collins B, Aebersold R. PMID: 24138574.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    15. Automated selected reaction monitoring data analysis workflow for large-scale targeted proteomic studies. Nat Protoc. 2013 Aug; 8(8):1602-19. Surinova S, Hüttenhain R, Chang CY, Espona L, Vitek O, Aebersold R. PMID: 23887179.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    16. Quantitative measurements of N-linked glycoproteins in human plasma by SWATH-MS. Proteomics. 2013 Apr; 13(8):1247-56. Liu Y, Hüttenhain R, Surinova S, Gillet LC, Mouritsen J, Brunner R, Navarro P, Aebersold R. PMID: 23322582.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    17. N-glycoprotein SRMAtlas: a resource of mass spectrometric assays for N-glycosites enabling consistent and multiplexed protein quantification for clinical applications. Mol Cell Proteomics. 2013 Apr; 12(4):1005-16. Hüttenhain R, Surinova S, Ossola R, Sun Z, Campbell D, Cerciello F, Schiess R, Bausch-Fluck D, Rosenberger G, Chen J, Rinner O, Kusebauch U, Hajdúch M, Moritz RL, Wollscheid B, Aebersold R. PMID: 23408683.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    18. Reproducible quantification of cancer-associated proteins in body fluids using targeted proteomics. Sci Transl Med. 2012 Jul 11; 4(142):142ra94. Hüttenhain R, Soste M, Selevsek N, Röst H, Sethi A, Carapito C, Farrah T, Deutsch EW, Kusebauch U, Moritz RL, Niméus-Malmström E, Rinner O, Aebersold R. PMID: 22786679.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    19. PASSEL: the PeptideAtlas SRMexperiment library. Proteomics. 2012 Apr; 12(8):1170-5. Farrah T, Deutsch EW, Kreisberg R, Sun Z, Campbell DS, Mendoza L, Kusebauch U, Brusniak MY, Hüttenhain R, Schiess R, Selevsek N, Aebersold R, Moritz RL. PMID: 22318887.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    20. Range of protein detection by selected/multiple reaction monitoring mass spectrometry in an unfractionated human cell culture lysate. Proteomics. 2012 Apr; 12(8):1185-93. Ebhardt HA, Sabidó E, Hüttenhain R, Collins B, Aebersold R. PMID: 22577020.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    21. Protein significance analysis in selected reaction monitoring (SRM) measurements. Mol Cell Proteomics. 2012 Apr; 11(4):M111.014662. Chang CY, Picotti P, Hüttenhain R, Heinzelmann-Schwarz V, Jovanovic M, Aebersold R, Vitek O. PMID: 22190732.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    22. mProphet: automated data processing and statistical validation for large-scale SRM experiments. Nat Methods. 2011 May; 8(5):430-5. Reiter L, Rinner O, Picotti P, Hüttenhain R, Beck M, Brusniak MY, Hengartner MO, Aebersold R. PMID: 21423193.
      View in: PubMed   Mentions: 123     Fields:    Translation:Humans
    23. On the development of plasma protein biomarkers. J Proteome Res. 2011 Jan 07; 10(1):5-16. Surinova S, Schiess R, Hüttenhain R, Cerciello F, Wollscheid B, Aebersold R. PMID: 21142170.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimals
    24. A combined top-down and bottom-up MS approach for the characterization of hemoglobin variants in Rhesus monkeys. Proteomics. 2010 Oct; 10(20):3657-68. Hüttenhain R, Hess S. PMID: 20848672.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    25. Perspectives of targeted mass spectrometry for protein biomarker verification. Curr Opin Chem Biol. 2009 Dec; 13(5-6):518-25. Hüttenhain R, Malmström J, Picotti P, Aebersold R. PMID: 19818677.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals