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Ryan Ash, MD, PhD

Photo of Ryan Ash, MD, PhD
Title(s)Assistant Professor, Psychiatry
SchoolSchool of Medicine
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    I am a psychiatrist and neuroscientist focused on translational neuroscience research. My lab’s overall goal is to implement image-guided transcranial focused ultrasound (FUS) technologies to rebalance synaptic stability and plasticity in the brain, as a treatment for disorders of excessive neural circuit stability including autism, OCD, Tourette, addiction, and PTSD. FUS has high spatial resolution (up to ~1 mm) that can be shaped to the target structure, can modulate neural activity through its impact on mechanosensitive ion channels, and can target biopharmaceuticals into the brain. My lab is currently advancing early-stage in-human studies using the visual system as a test-bed to optimize FUS neuromodulation, and we are organizing early-stage FUS clinical trials to ameliorate insistence on sameness symptoms in autism. Moreover, in preclinical models we use FUS-targeted biopharmaceuticals to modulate synaptic stability and normalize behavioral inflexibility in psychiatric disorders, in tandem with radiotracer-conjugated engineered antibodies to quantify synaptic stability with immuno-PET/SPECT. This work is among the first attempts to pursue theranostics-inspired approaches for plasticity-rebalancing treatment in severe psychiatric illness. I have a K08 career development award, a SFARI Fellows-to-Faculty award, Deeda Blair Initiative award, BBRF Young Investigator award, and start-up funds to support these projects. I have more than a year of silent retreat experience in the Vipassana meditation tradition. My clinical practice specialization is in functional neurological disorder, and I am interested in implementing psychedelic psychotherapy in this patient population.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Optimization of MR acoustic radiation force imaging (MR-ARFI) for human transcranial focused ultrasound. Magn Reson Med. 2025 Sep; 94(3):1060-1071. Mohammadjavadi M, Ash RT, Glover GH, Pauly KB. PMID: 40326562; PMCID: PMC12436201.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Stability of steady-state visual evoked potential contrast response functions. Psychophysiology. 2024 01; 61(1):e14412. Ash RT, Nix KC, Norcia AM. PMID: 37614220; PMCID: PMC10871127.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Transcranial ultrasound neuromodulation of the thalamic visual pathway in a large animal model and the dose-response relationship with MR-ARFI. Sci Rep. 2022 11 15; 12(1):19588. Mohammadjavadi M, Ash RT, Li N, Gaur P, Kubanek J, Saenz Y, Glover GH, Popelka GR, Norcia AM, Pauly KB. PMID: 36379960; PMCID: PMC9666449.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    4. MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning. Mol Brain. 2022 09 05; 15(1):76. Yue Y, Ash RT, Boyle N, Kinter A, Li Y, Zeng C, Lu H. PMID: 36064580; PMCID: PMC9446698.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism. J Neurosci. 2022 08 17; 42(33):6469-6482. Ash RT, Palagina G, Fernandez-Leon JA, Park J, Seilheimer R, Lee S, Sabharwal J, Reyes F, Wang J, Lu D, Sarfraz M, Froudarakis E, Tolias AS, Wu SM, Smirnakis SM. PMID: 35831173; PMCID: PMC9398540.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    6. Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit. Sci Adv. 2021 Oct 22; 7(43):eabf7467. Yue Y, Xu P, Liu Z, Sun X, Su J, Du H, Chen L, Ash RT, Smirnakis S, Simha R, Kusner L, Zeng C, Lu H. PMID: 34678068; PMCID: PMC8535852.
      View in: PubMed   Mentions: 11     Fields:    
    7. Inhibition of Elevated Ras-MAPK Signaling Normalizes Enhanced Motor Learning and Excessive Clustered Dendritic Spine Stabilization in the MECP2-Duplication Syndrome Mouse Model of Autism. eNeuro. 2021 Jul-Aug; 8(4). Ash RT, Buffington SA, Park J, Suter B, Costa-Mattioli M, Zoghbi HY, Smirnakis SM. PMID: 34021030; PMCID: PMC8260274.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    8. Excessive Formation and Stabilization of Dendritic Spine Clusters in the MECP2-Duplication Syndrome Mouse Model of Autism. eNeuro. 2021 Jan-Feb; 8(1). Ash RT, Park J, Suter B, Zoghbi HY, Smirnakis SM. PMID: 33168618; PMCID: PMC7877475.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    9. Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons. Nat Commun. 2019 11 26; 10(1):5372. Park J, Papoutsi A, Ash RT, Marin MA, Poirazi P, Smirnakis SM. PMID: 31772192; PMCID: PMC6879601.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    10. Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome. eNeuro. 2018 May-Jun; 5(3). Ash RT, Fahey PG, Park J, Zoghbi HY, Smirnakis SM. PMID: 30105297; PMCID: PMC6086213.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model. Neuron. 2016 Aug 17; 91(4):739-747. Lu H, Ash RT, He L, Kee SE, Wang W, Yu D, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HY. PMID: 27499081; PMCID: PMC5019177.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    12. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23; 29(6):701-15. Um K, Niu S, Duman JG, Cheng JX, Tu YK, Schwechter B, Liu F, Hiles L, Narayanan AS, Ash RT, Mulherkar S, Alpadi K, Smirnakis SM, Tolias KF. PMID: 24960694; PMCID: PMC4111230.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    13. Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome. J Neurosci. 2013 Dec 11; 33(50):19518-33. Jiang M, Ash RT, Baker SA, Suter B, Ferguson A, Park J, Rudy J, Torsky SP, Chao HT, Zoghbi HY, Smirnakis SM. PMID: 24336718; PMCID: PMC3858623.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    14. Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo. Eur J Neurosci. 2013 Apr; 37(8):1203-20. Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL. PMID: 23347239; PMCID: PMC3628093.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells