Sachin Sharma, PhD

Title(s)Postdoctoral Scholar, Medicine
SchoolSchool of Medicine
Address555 Mission Bay Blvd. South
Phone617-821-6487
ORCID ORCID Icon0000-0001-5161-6946 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Amity University , India Ph.D.2022Liver Diseases
    Chaudhary Charan Singh University, IndiaM.Sc.2012Biotechnology (Molecular Biology)
    Chaudhary Charan Singh University, India B.Sc.2010Biotechnology (Molecular Biology)
    Collapse Awards and Honors
    Council of Scientific and Industrial Research, Government of India, India2017  - 2020Senior Research Fellowship
    Council of Scientific and Industrial Research, Government of India, India 2015  - 2017Junior Research Fellowship

    Collapse Overview 
    Collapse Overview
    Research expertise in molecular biology, bioengineering, and various liver disease pre-clinical model to develop therapeutic or translational research for the treatment of liver diseases. Currently, our lab are focusing on development of antifibrotic therapies and identification of biomarkers to develop precision medicine for the treatment of liver disease patients. We have identified novel mechanisms to inactivate HSCs through targeting Acid Ceramidase (ASAH1) and Hippo Signaling as a strategy to treat patients with fibrosis. We also identified several targets, and validating their efficacy using conditional knockout mice in multiple model of liver diseases with fibrosis, including nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH).

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Context dependent role of p53 during the interaction of hepatocellular carcinoma and endothelial cells. Microvascular Research. 2022; 142:104374. . View Publication.
    2. Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction. Hepatology International. 2021; 6(15):1389. . View Publication.
    3. Divergent Effect of Birinapant, BV6 SMAC Mimetic on TNFα induced NF-κB Signaling and Cell Viability in Activated Hepatic Stellate Cell. Researchsquare(Preprint). 2021. . View Publication.
    4. Survivin expression is essential for early activation of hepatic stellate cells and fibrosis progression in chronic liver injury. Life Science Life Sciences. 2021; 32(287):120119. . View Publication.
    5. Cytoplasmic vacuolation with endoplasmic reticulum stress directs sorafenib induced non-apoptotic cell death in hepatic stellate cells. Scientific Reports. 2021; 1(11):3089. . View Publication.
    6. Extracellular Vesicles From Hepatitis B Patients Serve As Reservoir Of Hepatitis B Virus DNA. Journal of Viral Hepatitis. 2019; 1(26):211-214. . View Publication.
    7. Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis. Scientific Reports. 2018; 10264 . . View Publication.
    8. Immunology and Cell Biology. Impact of inhibitor of apoptosis proteins on immune modulation and inflammation. 2017; 3(95):236-243. . View Publication.
    9. BioMed Research International. Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development. 2014; 546274. . View Publication.