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Sachin Sharma, PhD

Photo of Sachin Sharma, PhD
Title(s)Postdoctoral Scholar, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #1401
San Francisco CA 94143
ORCID ORCID Icon0000-0001-5161-6946 Additional info
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    Collapse Biography 
    Collapse education and training
    Amity University , India Ph.D.2022Liver Diseases
    Chaudhary Charan Singh University, IndiaM.Sc.2012Biotechnology (Molecular Biology)
    Chaudhary Charan Singh University, India B.Sc.2010Biotechnology (Molecular Biology)
    Collapse awards and honors
    Council of Scientific and Industrial Research, Government of India, India2017  - 2020Senior Research Fellowship
    Council of Scientific and Industrial Research, Government of India, India 2015  - 2017Junior Research Fellowship

    Collapse Overview 
    Collapse overview
    Completed doctoral research in 2022 from Amity University, India with research specialization in liver injury and fibrosis progression. Outside of lab, I like to go hanging out with friends, outdoors hiking and exploring new places!

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation. Sci Transl Med. 2025 Aug 27; 17(813):eads9470. Sharma S, Prathigudupu V, Cable C, Serrano LR, Nerella S, Chen A, Hassan G, Lakins J, Valenzuela CL, Tsukui T, Ramamoorthi R, Kim JJ, Willenbring H, Mattis AN, Volk RF, Zaro BW, Coon JJ, Beresis R, DeGrado WF, Weaver VM, Christenson SA, Jo H, Chen JY. PMID: 40864684; PMCID: PMC12474517.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Exploration of a Class of Aryl Imidazolyl Ureas As Potent Acid Ceramidase Inhibitors for the Treatment of Fibrotic Diseases. ACS Omega. 2025 Aug 12; 10(31):34747-34761. Beresis R, Prathigudupu V, Cable C, Yu A, Adler M, Ramamoorthi R, Yeon SK, Gordan JD, Sharma S, DeGrado WF, Zaro B, Chen JY, Jo H. PMID: 40821548; PMCID: PMC12355242.
      View in: PubMed   Mentions:
    3. Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial Agents. J Med Chem. 2025 Feb 13; 68(3):3065-3087. Liu Q, Engelhart CA, Wallach JB, Tiwari D, Ge P, Manna A, Panda S, McCue WM, Wong TY, Sharma S, Jayasinghe YP, Fuller J, Ronning DR, Bockman MR, Cheung A, Dartois V, Zimmerman MD, Schnappinger D, Aldrich CC. PMID: 39823202.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis. Sci Rep. 2024 03 03; 14(1):5205. Shihan MH, Sharma S, Cable C, Prathigudupu V, Chen A, Mattis AN, Chen JY. PMID: 38433278; PMCID: PMC10909858.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Survivin inhibition ameliorates liver fibrosis by inducing hepatic stellate cell senescence and depleting hepatic macrophage population. J Cell Commun Signal. 2024 Mar; 18(1):e12015. Sharma S, Ghufran SM, Aftab M, Bihari C, Ghose S, Biswas S. PMID: 38545255; PMCID: PMC10964939.
      View in: PubMed   Mentions: 1  
    6. Exposure to environmental airborne particulate matter caused wide-ranged transcriptional changes and accelerated Alzheimer's-related pathology: A mouse study. Neurobiol Dis. 2023 Oct 15; 187:106307. Israel LL, Braubach O, Shatalova ES, Chepurna O, Sharma S, Klymyshyn D, Galstyan A, Chiechi A, Cox A, Herman D, Bliss B, Hasen I, Ting A, Arechavala R, Kleinman MT, Patil R, Holler E, Ljubimova JY, Koronyo-Hamaoui M, Sun T, Black KL. PMID: 37739136.
      View in: PubMed   Mentions: 4     Fields:    
    7. Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis. Nat Rev Gastroenterol Hepatol. 2023 10; 20(10):662-678. Sharma S, Le Guillou D, Chen JY. PMID: 37679454.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    8. Tiered sympathetic control of cardiac function revealed by viral tracing and single cell transcriptome profiling. Elife. 2023 05 10; 12. Sharma S, Littman R, Tompkins JD, Arneson D, Contreras J, Dajani AH, Ang K, Tsanhani A, Sun X, Jay PY, Herzog H, Yang X, Ajijola OA. PMID: 37162194; PMCID: PMC10212561.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Divergent effect of Birinapant, and BV6 SMAC mimetic on TNFα induced NF-κB signaling and cell viability in activated hepatic stellate cells. Mol Biol Rep. 2023 Mar; 50(3):2107-2117. Ghufran SM, Sharma S, Ghose S, Biswas S. PMID: 36542236.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    10. Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis. Front Med (Lausanne). 2022; 9:881848. Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY. PMID: 36275798; PMCID: PMC9582277.
      View in: PubMed   Mentions: 4  
    11. Context dependent role of p53 during the interaction of hepatocellular carcinoma and endothelial cells. Microvascular Research. 2022; 142:104374. Shaikh Maryam Ghufrana, Sachin Sharma, Sampa Ghose, Subhrajit Biswas. View Publication.
    12. Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). Eur J Med Chem. 2022 Mar 15; 232:114201. Hegde PV, Howe MD, Zimmerman MD, Boshoff HIM, Sharma S, Remache B, Jia Z, Pan Y, Baughn AD, Dartois V, Aldrich CC. PMID: 35219151; PMCID: PMC8941652.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19. Nat Commun. 2022 01 19; 13(1):383. Ray Y, Paul SR, Bandopadhyay P, D'Rozario R, Sarif J, Raychaudhuri D, Bhowmik D, Lahiri A, Vasudevan JS, Maurya R, Kanakan A, Sharma S, Kumar M, Singh P, Roy R, Chaudhury K, Maiti R, Bagchi S, Maiti A, Perwez MM, Mondal A, Tewari A, Mandal S, Roy A, Saha M, Biswas D, Maiti C, Bhaduri R, Chakraborty S, Sarkar BS, Haldar A, Saha B, Sengupta S, Pandey R, Chatterjee S, Bhattacharya P, Paul S, Ganguly D. PMID: 35046397; PMCID: PMC8770561.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCellsCTClinical Trials
    14. Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction. Hepatology International. 2021; 6(15):1389. Nidhi Nautiyal, Deepanshu Maheshwari, Dinesh Mani Tripathi, Dhananjay Kumar, Rekha Kumari, Suchi Gupta, Sachin Sharma, Sujata Mohanty, Anupama Parasar, Chhagan Bihari, Subhrajit Biswas, Archana Rastogi, Rakhi Maiwall, Anupam Kumar, Shiv Kumar Sarin. View Publication.
    15. Divergent Effect of Birinapant, BV6 SMAC Mimetic on TNFα induced NF-κB Signaling and Cell Viability in Activated Hepatic Stellate Cell. Researchsquare(Preprint). 2021. Sachin Sharma, Shaikh Maryam Ghufran, Sampa Ghose, Subhrajit Biswas. View Publication.
    16. Survivin expression is essential for early activation of hepatic stellate cells and fibrosis progression in chronic liver injury. Life Sci. 2021 Dec 15; 287:120119. Sharma S, Ghufran SM, Das B, Roy B, Ghose S, Biswas S. PMID: 34743004.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Survivin expression is essential for early activation of hepatic stellate cells and fibrosis progression in chronic liver injury. Life Science Life Sciences. 2021; 32(287):120119. Sachin Sharma, Shaikh Maryam Ghufran, Basundhara Das, Bornika Roy, Sampa Ghose Subhrajit Biswas. View Publication.
    18. Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction. Hepatol Int. 2021 Dec; 15(6):1389-1401. Nautiyal N, Maheshwari D, Tripathi DM, Kumar D, Kumari R, Gupta S, Sharma S, Mohanty S, Parasar A, Bihari C, Biswas S, Rastogi A, Maiwall R, Kumar A, Sarin SK. PMID: 34435344.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    19. Cytoplasmic vacuolation with endoplasmic reticulum stress directs sorafenib induced non-apoptotic cell death in hepatic stellate cells. Sci Rep. 2021 02 04; 11(1):3089. Sharma S, Ghufran SM, Ghose S, Biswas S. PMID: 33542321; PMCID: PMC7862314.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. Cytoplasmic vacuolation with endoplasmic reticulum stress directs sorafenib induced non-apoptotic cell death in hepatic stellate cells. Scientific Reports. 2021; 1(11):3089. Sachin Sharma, Shaikh Maryam Ghufran, Sampa Ghose, Subhrajit Biswas. View Publication.
    21. Extracellular Vesicles From Hepatitis B Patients Serve As Reservoir Of Hepatitis B Virus DNA. Journal of Viral Hepatitis. 2019; 1(26):211-214. Sukriti Sukriti, Manish Chandra Choudhary, Jaswinder Singh Maras, Sachin Sharma, Swati Thangariyal, Avishek Singh, Sukanto Das, Mojahidul Islam, Shvetank Sharma, Nirupama Trehanpati, Ekta Gupta, Shiv Kumar Sarin. View Publication.
    22. Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis. Scientific Reports. 2018; 10264 . Jaswinder Singh Maras, Sukanta Das, Sachin Sharma, Sukriti Sukriti, Jitendra kumar, Ashish Kumar Vyas, Dhananjay Kumar, Adil Bhat, Gaurav Yadav, Manish Chandra Choudhary, Shvetank Sharma, Guresh kumar, Chhagan Bihari, Nirupma Trehanpati, Rakhi Maiwall, Shiv Kumar Sarin . View Publication.
    23. Immunology and Cell Biology. Impact of inhibitor of apoptosis proteins on immune modulation and inflammation. 2017; 3(95):236-243. Sachin Sharma, Thomas Kaufmann, Subhrajit Biswas. View Publication.
    24. BioMed Research International. Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development. 2014; 546274. Madhu Khanna, Sachin Sharma, Binod Kumar, Roopali Rajput. View Publication.
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