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Sandra Erickson, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address3333 California Street
San Francisco CA 94118
Phone415-750-2005
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    Collapse Research 
    Collapse Research Activities and Funding
    Genetics of Nonalcoholic Fatty Liver Disease (NAFLD)
    NIH/NIDDK R01DK072187Apr 10, 2007 - Sep 30, 2013
    Role: Principal Investigator
    REGULATION OF HEPATIC CHOLESTEROL ESTER METABOLISM
    NIH/NIDDK R01DK038553Apr 1, 1988 - Mar 31, 1991
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zurkinden L, Solcà C, Vögeli IA, Vogt B, Ackermann D, Erickson S, Frey FJ, Sviridov D, Escher G. Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice. FASEB J. 2014 Mar; 28(3):1198-209. PMID: 24327605; PMCID: PMC4046167.
    2. Vögeli I, Jung HH, Dick B, Erickson S, Escher R, Funder JW, Frey FJ, Escher G. Evidence for a role of sterol 27-hydroxylase in glucocorticoid metabolism in vivo. J Endocrinol. 2013 Nov; 219(2):119-29. PMID: 24096962.
      View in: PubMed
    3. Li T, Francl JM, Boehme S, Ochoa A, Zhang Y, Klaassen CD, Erickson S, Chiang JY. Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. J Biol Chem. 2012 Jan 13; 287(3):1861-73. PMID: 22144677; PMCID: PMC3265867.
    4. DeBarber AE, Sandlers Y, Pappu AS, Merkens LS, Duell PB, Lear SR, Erickson S, Steiner RD. Profiling sterols in cerebrotendinous xanthomatosis: utility of Girard derivatization and high resolution exact mass LC-ESI-MS(n) analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 15; 879(17-18):1384-92. PMID: 21168372; PMCID: PMC3326078.
    5. Escher G, Vögeli I, Escher R, Tuckey RC, Erickson S, Krozowski Z, Frey FJ. Role of CYP27A1 in progesterone metabolism in vitro and in vivo. Am J Physiol Endocrinol Metab. 2009 Oct; 297(4):E949-55. PMID: 19671838.
      View in: PubMed
    6. Erickson S. Nonalcoholic fatty liver disease. J Lipid Res. 2009 Apr; 50 Suppl:S412-6. PMID: 19074370; PMCID: PMC2674744.
    7. Lee SJ, Heinrich G, Fedorova L, Al-Share QY, Ledford KJ, Fernstrom MA, McInerney MF, Erickson S, Gatto-Weis C, Najjar SM. Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. Gastroenterology. 2008 Dec; 135(6):2084-95. PMID: 18848945; PMCID: PMC2784638.
    8. Erickson S. Genes, environment, and lifespan: new insights into Niemann-Pick C disease. J Lipid Res. 2008 Mar; 49(3):497-8. PMID: 18199806.
      View in: PubMed
    9. Li X, Pandak WM, Erickson S, Ma Y, Yin L, Hylemon P, Ren S. Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. J Lipid Res. 2007 Dec; 48(12):2587-96. PMID: 17890683.
      View in: PubMed
    10. Dubrac S, Lear SR, Ananthanarayanan M, Balasubramaniyan N, Bollineni J, Shefer S, Hyogo H, Cohen DE, Blanche PJ, Krauss RM, Batta AK, Salen G, Suchy FJ, Maeda N, Erickson S. Role of CYP27A in cholesterol and bile acid metabolism. J Lipid Res. 2005 Jan; 46(1):76-85. PMID: 15520450.
      View in: PubMed
    11. Parini P, Davis M, Lada AT, Erickson S, Wright TL, Gustafsson U, Sahlin S, Einarsson C, Eriksson M, Angelin B, Tomoda H, Omura S, Willingham MC, Rudel LL. ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation. 2004 Oct 05; 110(14):2017-23. PMID: 15451793.
      View in: PubMed
    12. Dai T, Abou-Rjaily GA, Al-Share' QY, Yang Y, Fernström MA, Deangelis AM, Lee AD, Sweetman L, Amato A, Pasquali M, Lopaschuk GD, Erickson S, Najjar SM. Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice. J Biol Chem. 2004 Oct 22; 279(43):45155-61. PMID: 15316023.
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    13. Xu G, Li H, Pan LX, Shang Q, Honda A, Ananthanarayanan M, Erickson S, Shneider BL, Shefer S, Bollineni J, Forman BM, Matsuzaki Y, Suchy FJ, Tint GS, Salen G. FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits. J Lipid Res. 2003 Oct; 44(10):1956-62. PMID: 12897188.
      View in: PubMed
    14. Erickson S, Lear SR, Deane S, Dubrac S, Huling SL, Nguyen L, Bollineni JS, Shefer S, Hyogo H, Cohen DE, Shneider B, Sehayek E, Ananthanarayanan M, Balasubramaniyan N, Suchy FJ, Batta AK, Salen G. Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice. J Lipid Res. 2003 May; 44(5):1001-9. PMID: 12588950.
      View in: PubMed
    15. Dussault I, Yoo HD, Lin M, Wang E, Fan M, Batta AK, Salen G, Erickson S, Forman BM. Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):833-8. PMID: 12569201; PMCID: PMC298687.
    16. Thorngate FE, Strockbine PA, Erickson S, Williams DL. Altered adrenal gland cholesterol metabolism in the apoE-deficient mouse. J Lipid Res. 2002 Nov; 43(11):1920-6. PMID: 12401891.
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    17. Xu G, Pan LX, Li H, Forman BM, Erickson S, Shefer S, Bollineni J, Batta AK, Christie J, Wang TH, Michel J, Yang S, Tsai R, Lai L, Shimada K, Tint GS, Salen G. Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits. J Biol Chem. 2002 Dec 27; 277(52):50491-6. PMID: 12401785.
      View in: PubMed
    18. Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson S, Verhagen A, Rivera CR, Mulvihill SJ, Malloy MJ, Kane JP. Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest. 2002 Jul; 110(1):109-17. PMID: 12093894; PMCID: PMC151029.
    19. Xu G, Pan LX, Erickson S, Forman BM, Shneider BL, Ananthanarayanan M, Li X, Shefer S, Balasubramanian N, Ma L, Asaoka H, Lear SR, Nguyen LB, Dussault I, Suchy FJ, Tint GS, Salen G. Removal of the bile acid pool upregulates cholesterol 7alpha-hydroxylase by deactivating FXR in rabbits. J Lipid Res. 2002 Jan; 43(1):45-50. PMID: 11792721.
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    20. Honda A, Salen G, Matsuzaki Y, Batta AK, Xu G, Leitersdorf E, Tint GS, Erickson S, Tanaka N, Shefer S. Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis. J Biol Chem. 2001 Sep 14; 276(37):34579-85. PMID: 11454857.
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    21. Zhang Z, Li D, Blanchard DE, Lear SR, Erickson S, Spencer TA. Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. J Lipid Res. 2001 Apr; 42(4):649-58. PMID: 11290837.
      View in: PubMed
    22. Honda A, Salen G, Matsuzaki Y, Batta AK, Xu G, Leitersdorf E, Tint GS, Erickson S, Tanaka N, Shefer S. Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX. J Lipid Res. 2001 Feb; 42(2):291-300. PMID: 11181760.
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    23. Shi W, Swan KF, Lear SR, O'Neil JS, Erickson S, Henson MC. Regulation of pathways determining cholesterol availability in the baboon placenta with advancing gestation. Biol Reprod. 1999 Dec; 61(6):1499-505. PMID: 10569995.
      View in: PubMed
    24. Hamilton RL, Moorehouse A, Lear SR, Wong JS, Erickson S. A rapid calcium precipitation method of recovering large amounts of highly pure hepatocyte rough endoplasmic reticulum. J Lipid Res. 1999 Jun; 40(6):1140-7. PMID: 10357846.
      View in: PubMed
    25. Massimi M, Lear SR, Williams DL, Jones AL, Erickson S. Differential expression of apolipoprotein E messenger RNA within the rat liver lobule determined by in situ hybridization. Hepatology. 1999 May; 29(5):1549-55. PMID: 10216141.
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    26. Erickson S. International Congress of Biochemistry and Molecular Biology Satellite Conference: cellular cholesterol ester metabolism. J Lipid Res. 1998 Nov; 39(11):2300-3. PMID: 9799817.
      View in: PubMed
    27. Smith JL, Lear SR, Forte TM, Ko W, Massimi M, Erickson S. Effect of pregnancy and lactation on lipoprotein and cholesterol metabolism in the rat. J Lipid Res. 1998 Nov; 39(11):2237-49. PMID: 9799810.
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    28. Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson S, Farese RV. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13018-23. PMID: 9789033; PMCID: PMC23692.
    29. Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson S, Farese RV. ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem. 1998 Oct 09; 273(41):26755-64. PMID: 9756919.
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    30. Massimi M, Lear SR, Huling SL, Jones AL, Erickson S. Cholesterol 7alpha-hydroxylase (CYP7A): patterns of messenger RNA expression during rat liver development. Hepatology. 1998 Oct; 28(4):1064-72. PMID: 9755244.
      View in: PubMed
    31. Vergara-Jimenez M, Conde K, Erickson S, Fernandez ML. Hypolipidemic mechanisms of pectin and psyllium in guinea pigs fed high fat-sucrose diets: alterations on hepatic cholesterol metabolism. J Lipid Res. 1998 Jul; 39(7):1455-65. PMID: 9684749.
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    32. Meiner V, Tam C, Gunn MD, Dong LM, Weisgraber KH, Novak S, Myers HM, Erickson S, Farese RV. Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. J Lipid Res. 1997 Sep; 38(9):1928-33. PMID: 9323603.
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    33. Plump AS, Erickson S, Weng W, Partin JS, Breslow JL, Williams DL. Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production. J Clin Invest. 1996 Jun 01; 97(11):2660-71. PMID: 8647961; PMCID: PMC507354.
    34. Erickson S, Van Zuiden PE. Effects of bile salts on rat hepatic acyl CoA:cholesterol acyltransferase. Lipids. 1995 Oct; 30(10):911-5. PMID: 8538378.
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    35. Fernandez ML, Ruiz LR, Conde AK, Sun DM, Erickson S, McNamara DJ. Psyllium reduces plasma LDL in guinea pigs by altering hepatic cholesterol homeostasis. J Lipid Res. 1995 May; 36(5):1128-38. PMID: 7658161.
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    36. Smith JL, Lear SR, Erickson S. Developmental expression of elements of hepatic cholesterol metabolism in the rat. J Lipid Res. 1995 Apr; 36(4):641-52. PMID: 7616112.
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    37. Erickson S, Lear SR, McCreery MJ. Functional sizes of hepatic enzymes of cholesteryl ester metabolism determined by radiation inactivation. J Lipid Res. 1994 May; 35(5):763-9. PMID: 7915298.
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    38. Voyno-Yasenetskaya TA, Dobbs LG, Erickson S, Hamilton RL. Low density lipoprotein- and high density lipoprotein-mediated signal transduction and exocytosis in alveolar type II cells. Proc Natl Acad Sci U S A. 1993 May 01; 90(9):4256-60. PMID: 8483941; PMCID: PMC46485.
    39. Erickson S, Lear SR, Barker ME, Musliner TA. Regulation of cholesterol metabolism in the ethionine-induced premalignant rat liver. J Lipid Res. 1990 May; 31(5):933-45. PMID: 2380640.
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    40. Erickson S, Jaeckle S, Lear SR, Brady SM, Havel RJ. Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol-treated rats. J Lipid Res. 1989 Nov; 30(11):1763-71. PMID: 2614275.
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    41. Mendel CM, Kunitake ST, Hong K, Erickson S, Kane JP, Kempner ES. Radiation inactivation of binding sites for high-density lipoproteins in human liver membranes. Biochim Biophys Acta. 1988 Jul 22; 961(2):188-93. PMID: 2839235.
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    42. Stone BG, Erickson S, Craig WY, Cooper AD. Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism. Evidence for a distinct biliary precursor pool. J Clin Invest. 1985 Nov; 76(5):1773-81. PMID: 4056052; PMCID: PMC424205.
    43. Barnard GF, Erickson S, Cooper AD. Lipoprotein metabolism by rat hepatomas. Studies on the etiology of defective dietary feedback inhibition of cholesterol synthesis. J Clin Invest. 1984 Jul; 74(1):173-84. PMID: 6330173; PMCID: PMC425198.
    44. Erickson S, Bösterling B. Cholesterol 7 alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles. J Lipid Res. 1981 Jul; 22(5):872-6. PMID: 7288293.
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